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Paul Sternweis

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TOP 3
Lily I Jiang; Paul C Sternweis; Jennifer E Wang
Zymosan activates protein kinase A via adenylyl cyclase VII to modulate innate immune responses during inflammation.
Frank Medina; Angela M Carter; Zhe Chen; Olugbenga Dada; Stephen Gutowski; Jana Hadas; Paul C Sternweis
Activated RhoA Is a Positive Feedback Regulator of the Lbc Family of Rho Guanine Nucleotide Exchange Factor Proteins.
Lily I Jiang; Jennifer E Wang; Paul C Sternweis
Regions on adenylyl cyclase VII required for selective regulation by the G13 pathway.

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All Publications

2013: Lily I Jiang; Paul C Sternweis; Jennifer E Wang
Zymosan activates protein kinase A via adenylyl cyclase VII to modulate innate immune responses during inflammation.
Molecular immunology 2013;54(1):14-22.
2013: Frank Medina; Angela M Carter; Zhe Chen; Olugbenga Dada; Stephen Gutowski; Jana Hadas; Paul C Sternweis
Activated RhoA Is a Positive Feedback Regulator of the Lbc Family of Rho Guanine Nucleotide Exchange Factor Proteins.
The Journal of biological chemistry 2013;288(16):11325-33.
2013: Lily I Jiang; Jennifer E Wang; Paul C Sternweis
Regions on adenylyl cyclase VII required for selective regulation by the G13 pathway.
Molecular pharmacology 2013;83(3):587-93.
2012: Zhe Chen; Liang Guo; Stephen Gutowski; Jana Hadas; Stephen R Sprang; Paul C Sternweis
Activation of p115-RhoGEF requires direct association of Gα13 and the Dbl homology domain.
The Journal of biological chemistry 2012;287(30):25490-500.
2011: Zhe Chen; Liang Guo; Stephen R Sprang; Paul C Sternweis
Modulation of a GEF switch: autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoGEF.
Protein science : a publication of the Protein Society 2011;20(1):107-17.
2010: Zhe Chen; Frank Medina; Mu-ya Liu; Celestine Thomas; Stephen R Sprang; Paul C Sternweis
Activated RhoA binds to the pleckstrin homology (PH) domain of PDZ-RhoGEF, a potential site for autoregulation.
The Journal of biological chemistry 2010;285(27):21070-81.
2010: Biyan Duan; Richard Davis; Eva L Sadat; Julie Collins; Paul C Sternweis; Dorothy Yuan; Lily I Jiang
Distinct roles of adenylyl cyclase VII in regulating the immune responses in mice.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(1):335-44.
2010: Hannah L Callender; Mary Ann Horn; Dianne L DeCamp; Paul C Sternweis; H Alex Brown
Modeling species-specific diacylglycerol dynamics in the RAW 264.7 macrophage.
Journal of theoretical biology 2010;262(4):679-90.
2009: Estelle A Wall; Joelle R Zavzavadjian; Mi Sook Chang; Baljinder Randhawa; Xiaocui Zhu; Robert C Hsueh; Jamie Liu; Adrienne Driver; Xiaoyan Robert Bao; Paul C Sternweis; Melvin I Simon; Iain D C Fraser
Suppression of LPS-induced TNF-alpha production in macrophages by cAMP is mediated by PKA-AKAP95-p105.
Science signaling 2009;2(75):ra28.
2009: Robert C Hsueh; Madhusudan Natarajan; Iain Fraser; Blake Pond; Jamie Liu; Susanne Mumby; Heping Han; Lily I Jiang; Melvin I Simon; Ronald Taussig; Paul C Sternweis
Deciphering signaling outcomes from a system of complex networks.
Science signaling 2009;2(71):ra22.
2008: Zhe Chen; William D Singer; Shahab M Danesh; Paul C Sternweis; Stephen R Sprang
Recognition of the activated states of Galpha13 by the rgRGS domain of PDZRhoGEF.
Structure (London, England : 1993) 2008;16(10):1532-43.
2008: Lily I Jiang; Julie Collins; Richard Davis; Iain D Fraser; Paul C Sternweis
Regulation of cAMP responses by the G12/13 pathway converges on adenylyl cyclase VII.
The Journal of biological chemistry 2008;283(34):23429-39.
2008: Tamara I A Roach; Robert A Rebres; Iain D C Fraser; Dianne L Decamp; Keng-Mean Lin; Paul C Sternweis; Mel I Simon; William Seaman
Signaling and cross-talk by C5a and UDP in macrophages selectively use PLCbeta3 to regulate intracellular free calcium.
The Journal of biological chemistry 2008;283(25):17351-61.
2007: Lily I Jiang; Julie Collins; Richard Davis; Keng-Mean Lin; Dianne DeCamp; Tamara Roach; Robert C Hsueh; Robert A Rebres; Elliott M Ross; Ronald Taussig; Iain Fraser; Paul C Sternweis
Use of a cAMP BRET sensor to characterize a novel regulation of cAMP by the sphingosine 1-phosphate/G13 pathway.
The Journal of biological chemistry 2007;282(14):10576-84.
2007: Paul C Sternweis; Angela M Carter; Zhe Chen; Shahab M Danesh; Ying-Fan Hsiung; William D Singer
Regulation of Rho guanine nucleotide exchange factors by G proteins.
Advances in protein chemistry 2007;74():189-228.
2006: Madhusudan Natarajan; Keng-Mean Lin; Robert C Hsueh; Paul C Sternweis; Rama Ranganathan
A global analysis of cross-talk in a mammalian cellular signalling network.
Nature cell biology 2006;8(6):571-80.
2005: Zhe Chen; William D Singer; Paul C Sternweis; Stephen R Sprang
Structure of the p115RhoGEF rgRGS domain-Galpha13/i1 chimera complex suggests convergent evolution of a GTPase activator.
Nature structural & molecular biology 2005;12(2):191-7.
2004: Qin Wang; Min Liu; Tohru Kozasa; Jeffrey rothstein; Paul C Sternweis; Richard Neubig
Thrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cells.
The Journal of biological chemistry 2004;279(28):28831-4.
2004: Ewen D Gallagher; Stephen Gutowski; Paul C Sternweis; Melanie H Cobb
RhoA binds to the amino terminus of MEKK1 and regulates its kinase activity.
The Journal of biological chemistry 2004;279(3):1872-7.
2004: Qin Wang; Min Liu; Tohru Kozasa; Jeffrey D Rothestein; Paul C Sternweis; Richard Neubig
Ribozyme- and siRNA-mediated suppression of RGS-containing RhoGEF proteins.
Methods in enzymology 2004;389():244-65.
2003: Zhe Chen; William D Singer; Clark D Wells; Stephen R Sprang; Paul C Sternweis
Mapping the Galpha13 binding interface of the rgRGS domain of p115RhoGEF.
The Journal of biological chemistry 2003;278(11):9912-9.
2002: Lori B Christerson; Ewen Gallagher; Colleen A Vanderbilt; Angelique Whitehurst; Clark Wells; Roxana Kazempour; Paul C Sternweis; Melanie H Cobb
p115 Rho GTPase activating protein interacts with MEKK1.
Journal of cellular physiology 2002;192(2):200-8.
2002: Clark D Wells; Mu-Ya Liu; Mandy Jackson; Stephen Gutowski; Pamela M Sternweis; Jeffrey rothstein; Tohru Kozasa; Paul C Sternweis
Mechanisms for reversible regulation between G13 and Rho exchange factors.
The Journal of biological chemistry 2002;277(2):1174-81.
2002: Clark Wells; Xuejun Jiang; Stephen Gutowski; Paul C Sternweis
Functional characterization of p115 RhoGEF.
Methods in enzymology 2002;345():371-82.
2002: Xuejun Jiang; Stephen Gutowski; William D Singer; Paul C Sternweis
Assays and characterization of mammalian phosphatidylinositol 4,5-bisphosphate-sensitive phospholipase D.
Methods in enzymology 2002;345():328-34.
2001: Zhe Chen; Clark D Wells; Paul C Sternweis; Stephen R Sprang
Structure of the rgRGS domain of p115RhoGEF.
Nature structural biology 2001;8(9):805-9.
2001: Clark D Wells; Stephen Gutowski; Gideon Bollag; Paul C Sternweis
Identification of potential mechanisms for regulation of p115 RhoGEF through analysis of endogenous and mutant forms of the exchange factor.
The Journal of biological chemistry 2001;276(31):28897-905.
2001: M Y Liu; Stephen Gutowski; Paul C Sternweis
The C terminus of mammalian phospholipase D is required for catalytic activity.
The Journal of biological chemistry 2001;276(8):5556-62.
1999: Alexander Lazar; Xiaocheng Chen; J Rush; Bruce F Horazdovsky; Charles J Waechter; George M Carman; Paul C Sternweis
The LPP1 and DPP1 gene products account for most of the isoprenoid phosphate phosphatase activities in Saccharomyces cerevisiae.
The Journal of biological chemistry 1999;274(21):14831-7.
1998: Matthew J Hart; Xuejun Jiang; Tohru Kozasa; W Roscoe; William D Singer; Alfred G Gilman; Paul C Sternweis; Gideon Bollag
Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13.
Science (New York, N.Y.) 1998;280(5372):2112-4.
1998: Tohru Kozasa; Xuejun Jiang; Matthew J Hart; Pamela M Sternweis; William D Singer; Alfred G Gilman; Gideon Bollag; Paul C Sternweis
p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13.
Science (New York, N.Y.) 1998;280(5372):2109-11.
1997: Michael Roth; Paul C Sternweis
The role of lipid signaling in constitutive membrane traffic.
Current opinion in cell biology 1997;9(4):519-26.
1997: Palmer Taylor; Elliott M Ross; Paul C Sternweis; Richard Neubig; J Andrew McCammon
Colloquium on signaling and molecular structure in pharmacology (La Jolla, California, March 11-12, 1997).
Molecular pharmacology 1997;52(1):1-5.
1997: M A Wilk-Blaszczak; William D Singer; T Quill; B Miller; Jeffrey A Frost; Paul C Sternweis; F Belardetti
The monomeric G-proteins Rac1 and/or Cdc42 are required for the inhibition of voltage-dependent calcium current by bradykinin.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(11):4094-100.
1997: William D Singer; H A Brown; Paul C Sternweis
Regulation of eukaryotic phosphatidylinositol-specific phospholipase C and phospholipase D.
Annual review of biochemistry 1997;66():475-509.
1996: Nicholas T Ktistakis; H A Brown; M G Waters; Paul C Sternweis; Michael Roth
Evidence that phospholipase D mediates ADP ribosylation factor-dependent formation of Golgi coated vesicles.
The Journal of cell biology 1996;134(2):295-306.
1996: William D Singer; H A Brown; Xuejun Jiang; Paul C Sternweis
Regulation of phospholipase D by protein kinase C is synergistic with ADP-ribosylation factor and independent of protein kinase activity.
The Journal of biological chemistry 1996;271(8):4504-10.
1995: William D Singer; H A Brown; G M Bokoch; Paul C Sternweis
Resolved phospholipase D activity is modulated by cytosolic factors other than Arf.
The Journal of biological chemistry 1995;270(25):14944-50.
1995: H A Brown; S Gutowski; Richard A Kahn; Paul C Sternweis
Partial purification and characterization of Arf-sensitive phospholipase D from porcine brain.
The Journal of biological chemistry 1995;270(25):14935-43.
1995: Nicholas T Ktistakis; H A Brown; Paul C Sternweis; Michael Roth
Phospholipase D is present on Golgi-enriched membranes and its activation by ADP ribosylation factor is sensitive to brefeldin A.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(11):4952-6.
1995: H A Brown; Paul C Sternweis
Stimulation of phospholipase D by ADP-ribosylation factor.
Methods in enzymology 1995;257():313-24.
1994: M A Wilk-Blaszczak; William D Singer; S Gutowski; Paul C Sternweis; F Belardetti
The G protein G13 mediates inhibition of voltage-dependent calcium current by bradykinin.
Neuron 1994;13(5):1215-24.
1994: William D Singer; R T Miller; Paul C Sternweis
Purification and characterization of the alpha subunit of G13.
The Journal of biological chemistry 1994;269(31):19796-802.
1994: Len Stephens; A Smrcka; F T Cooke; Trevor Jackson; Paul C Sternweis; Phillip T Hawkins
A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein beta gamma subunits.
Cell 1994;77(1):83-93.
1994: Paul C Sternweis
The active role of beta gamma in signal transduction.
Current opinion in cell biology 1994;6(2):198-203.
1994: M A Wilk-Blaszczak; S Gutowski; Paul C Sternweis; F Belardetti
Bradykinin modulates potassium and calcium currents in neuroblastoma hybrid cells via different pertussis toxin-insensitive pathways.
Neuron 1994;12(1):109-16.
1994: Iok-Hou Pang; A V Smrcka; Paul C Sternweis
Synthesis and applications of affinity matrix containing immobilized beta gamma subunits of G proteins.
Methods in enzymology 1994;237():164-74.
1993: H A Brown; S Gutowski; Carolyn Moomaw; C Slaughter; Paul C Sternweis
ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity.
Cell 1993;75(6):1137-44.
1993: Tohru Kozasa; John R Hepler; A V Smrcka; M I Simon; S G Rhee; Paul C Sternweis; Alfred G Gilman
Purification and characterization of recombinant G16 alpha from Sf9 cells: activation of purified phospholipase C isozymes by G-protein alpha subunits.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(19):9176-80.
1993: John R Hepler; Tohru Kozasa; A V Smrcka; M I Simon; S G Rhee; Paul C Sternweis; Alfred G Gilman
Purification from Sf9 cells and characterization of recombinant Gq alpha and G11 alpha. Activation of purified phospholipase C isozymes by G alpha subunits.
The Journal of biological chemistry 1993;268(19):14367-75.
1993: A V Smrcka; Paul C Sternweis
Regulation of purified subtypes of phosphatidylinositol-specific phospholipase C beta by G protein alpha and beta gamma subunits.
The Journal of biological chemistry 1993;268(13):9667-74.
1993: Paul C Sternweis; A V Smrcka
G proteins in signal transduction: the regulation of phospholipase C.
Ciba Foundation symposium 1993;176():96-106; discussion 106-11.
1992: Paul C Sternweis; A V Smrcka
Regulation of phospholipase C by G proteins.
Trends in biochemical sciences 1992;17(12):502-6.
1992: Paul C Sternweis; A V Smrcka; S Gutowski
Hormone signalling via G-protein: regulation of phosphatidylinositol 4,5-bisphosphate hydrolysis by Gq.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1992;336(1276):35-41; discussion 41-2.
1992: G Berstein; J L Blank; A V Smrcka; T Higashijima; Paul C Sternweis; John H Exton; Elliott M Ross
Reconstitution of agonist-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis using purified m1 muscarinic receptor, Gq/11, and phospholipase C-beta 1.
The Journal of biological chemistry 1992;267(12):8081-8.
1992: K H Muntz; Paul C Sternweis; Alfred G Gilman; Susanne M Mumby
Influence of gamma subunit prenylation on association of guanine nucleotide-binding regulatory proteins with membranes.
Molecular biology of the cell 1992;3(1):49-61.
1991: R Munshi; Iok-Hou Pang; Paul C Sternweis; Joel Linden
A1 adenosine receptors of bovine brain couple to guanine nucleotide-binding proteins Gi1, Gi2, and Go.
The Journal of biological chemistry 1991;266(33):22285-9.
1991: S Gutowski; A Smrcka; L Nowak; D G Wu; M Simon; Paul C Sternweis
Antibodies to the alpha q subfamily of guanine nucleotide-binding regulatory protein alpha subunits attenuate activation of phosphatidylinositol 4,5-bisphosphate hydrolysis by hormones.
The Journal of biological chemistry 1991;266(30):20519-24.
1991: R L Wange; A V Smrcka; Paul C Sternweis; John H Exton
Photoaffinity labeling of two rat liver plasma membrane proteins with [32P]gamma-azidoanilido GTP in response to vasopressin. Immunologic identification as alpha subunits of the Gq class of G proteins.
The Journal of biological chemistry 1991;266(18):11409-12.
1991: Maurine E Linder; Iok-Hou Pang; Robert J Duronio; J I Gordon; Paul C Sternweis; Alfred G Gilman
Lipid modifications of G protein subunits. Myristoylation of Go alpha increases its affinity for beta gamma.
The Journal of biological chemistry 1991;266(7):4654-9.
1991: A V Smrcka; John R Hepler; K O Brown; Paul C Sternweis
Regulation of polyphosphoinositide-specific phospholipase C activity by purified Gq.
Science (New York, N.Y.) 1991;251(4995):804-7.
1990: Iok-Hou Pang; Paul C Sternweis
Purification of unique alpha subunits of GTP-binding regulatory proteins (G proteins) by affinity chromatography with immobilized beta gamma subunits.
The Journal of biological chemistry 1990;265(30):18707-12.
1990: Susanne M Mumby; P J Casey; Alfred G Gilman; S Gutowski; Paul C Sternweis
G protein gamma subunits contain a 20-carbon isoprenoid.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(15):5873-7.
1990: Paul C Sternweis; Iok-Hou Pang
The G protein-channel connection.
Trends in neurosciences 1990;13(4):122-6.
1990: Paul C Sternweis; Iok-Hou Pang
Mechanisms of G protein action: insight from reconstitution.
Society of General Physiologists series 1990;45():197-205.
1989: Iok-Hou Pang; Paul C Sternweis
Isolation of the alpha subunits of GTP-binding regulatory proteins by affinity chromatography with immobilized beta gamma subunits.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(20):7814-8.
1989: V A Florio; Paul C Sternweis
Mechanisms of muscarinic receptor action on Go in reconstituted phospholipid vesicles.
The Journal of biological chemistry 1989;264(7):3909-15.
1989: D A Ewald; Iok-Hou Pang; Paul C Sternweis; Richard J Miller
Differential G protein-mediated coupling of neurotransmitter receptors to Ca2+ channels in rat dorsal root ganglion neurons in vitro.
Neuron 1989;2(2):1185-93.
1988: D A Ewald; Paul C Sternweis; Richard J Miller
Guanine nucleotide-binding protein Go-induced coupling of neuropeptide Y receptors to Ca2+ channels in sensory neurons.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(10):3633-7.
1988: Susanne M Mumby; Iok-Hou Pang; Alfred G Gilman; Paul C Sternweis
Chromatographic resolution and immunologic identification of the alpha 40 and alpha 41 subunits of guanine nucleotide-binding regulatory proteins from bovine brain.
The Journal of biological chemistry 1988;263(4):2020-6.
1987: T Higashijima; K M Ferguson; Paul C Sternweis
Regulation of hormone-sensitive GTP-dependent regulatory proteins by chloride.
The Journal of biological chemistry 1987;262(8):3597-602.
1987: T Higashijima; K M Ferguson; Paul C Sternweis; M D Smigel; Alfred G Gilman
Effects of Mg2+ and the beta gamma-subunit complex on the interactions of guanine nucleotides with G proteins.
The Journal of biological chemistry 1987;262(2):762-6.
1987: T Higashijima; K M Ferguson; Paul C Sternweis; Elliott M Ross; M D Smigel; Alfred G Gilman
The effect of activating ligands on the intrinsic fluorescence of guanine nucleotide-binding regulatory proteins.
The Journal of biological chemistry 1987;262(2):752-6.
1985: V A Florio; Paul C Sternweis
Reconstitution of resolved muscarinic cholinergic receptors with purified GTP-binding proteins.
The Journal of biological chemistry 1985;260(6):3477-83.
1983: J K Northup; M D Smigel; Paul C Sternweis; Alfred G Gilman
The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution of the activated 45,000-dalton (alpha) subunit.
The Journal of biological chemistry 1983;258(18):11369-76.
1983: J K Northup; Paul C Sternweis; Alfred G Gilman
The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution, activity, and properties of the 35,000-dalton (beta) subunit.
The Journal of biological chemistry 1983;258(18):11361-8.
1982: L S Schleifer; Richard A Kahn; E Hanski; J K Northup; Paul C Sternweis; Alfred G Gilman
Requirements for cholera toxin-dependent ADP-ribosylation of the purified regulatory component of adenylate cyclase.
The Journal of biological chemistry 1982;257(1):20-3.
1981: E Hanski; Paul C Sternweis; J K Northup; A W Dromerick; Alfred G Gilman
The regulatory component of adenylate cyclase. Purification and properties of the turkey erythrocyte protein.
The Journal of biological chemistry 1981;256(24):12911-9.
1981: Paul C Sternweis; J K Northup; M D Smigel; Alfred G Gilman
The regulatory component of adenylate cyclase. Purification and properties.
The Journal of biological chemistry 1981;256(22):11517-26.
1981: Paul C Sternweis; J K Northup; E Hanski; L S Schleifer; M D Smigel; Alfred G Gilman
Purification and properties of the regulatory component (G/F) of adenylate cyclase.
Advances in cyclic nucleotide research 1981;14():23-36.
1980: J K Northup; Paul C Sternweis; M D Smigel; L S Schleifer; Elliott M Ross; Alfred G Gilman
Purification of the regulatory component of adenylate cyclase.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(11):6516-20.
1980: L S Schleifer; J C Garrison; Paul C Sternweis; J K Northup; Alfred G Gilman
The regulatory component of adenylate cyclase from uncoupled S49 lymphoma cells differs in charge from the wild type protein.
The Journal of biological chemistry 1980;255(7):2641-4.