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Alasdair Steven

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Jessica Z Bereszczak; Rebecca J Rose; Alasdair C Steven; Esther van Duijn; Norman R Watts; Paul T Wingfield; Albert J R Heck
Epitope-distal Effects Accompany the Binding of Two Distinct Antibodies to Hepatitis B Virus Capsids.
Juan Fontana; Alasdair C Steven
At Low pH, Influenza Virus Matrix Protein M1 Undergoes a Conformational Change Prior to Dissociating from the Membrane.
Michael A DiMattia; Jonathan M Grimes; Stephen J Stahl; Alasdair C Steven; David I Stuart; Norman R Watts; Paul T Wingfield
Antigenic switching of hepatitis B virus by alternative dimerization of the capsid protein.

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2013: Jessica Z Bereszczak; Rebecca J Rose; Alasdair C Steven; Esther van Duijn; Norman R Watts; Paul T Wingfield; Albert J R Heck
Epitope-distal Effects Accompany the Binding of Two Distinct Antibodies to Hepatitis B Virus Capsids.
Journal of the American Chemical Society 2013;135(17):6504-12.
2013: Juan Fontana; Alasdair C Steven
At Low pH, Influenza Virus Matrix Protein M1 Undergoes a Conformational Change Prior to Dissociating from the Membrane.
Journal of virology 2013;87(10):5621-8.
2013: Michael A DiMattia; Jonathan M Grimes; Stephen J Stahl; Alasdair C Steven; David I Stuart; Norman R Watts; Paul T Wingfield
Antigenic switching of hepatitis B virus by alternative dimerization of the capsid protein.
Structure (London, England : 1993) 2013;21(1):133-42.
2013: Weimin Wu; Norman R Watts; Paul T Wingfield; Zhaochun Chen; Naiqian Cheng; Patrizia Farci; Robert H Purcell; Stephen J Stahl; Alasdair C Steven
Specificity of an anti-capsid antibody associated with Hepatitis B Virus-related acute liver failure.
Journal of structural biology 2013;181(1):53-60.
2012: Giovanni Cardone; Juan Fontana; Matthew Brecher; Carmen Butan; Judith M White; Dennis C Winkler; Alasdair C Steven
Visualization of the two-step fusion process of the retrovirus avian sarcoma/leukosis virus by cryo-electron tomography.
Journal of virology 2012;86(22):12129-37.
2012: Daniel Nemecek; Jian Qiao; Alasdair C Steven; Leonard Mindich; J Bernard Heymann
Packaging accessory protein P7 and polymerase P2 have mutually occluding binding sites inside the bacteriophage 6 procapsid.
Journal of virology 2012;86(21):11616-24.
2012: Anthony J Battisti; Teryl K Frey; Richard J Kuhn; Pavel Plevka; Alasdair C Steven; Dennis C Winkler; Joshua D Yoder; Vidya Mangala Prasad; Michael G Rossmann
Cryo-electron tomography of rubella virus.
Journal of virology 2012;86(20):11078-85.
2012: Ana J Pérez-Berná; Alasdair C Steven; Dennis C Winkler; Pedro J de Pablo; S Jane Flint; Margarita Menéndez; Rosa Menéndez-Conejero; Alvaro Ortega-Esteban; Carmen San Martín
The role of capsid maturation on adenovirus priming for sequential uncoating.
The Journal of biological chemistry 2012;287(37):31582-95.
2012: Benoît Derrien; Joseph Ebenezer; Grégory Effantin; Giulia Friso; Wojciech Majeran; Michael R Maurizi; Alasdair C Steven; Klaas J van Wijk; Olivier Vallon
The purification of the Chlamydomonas reinhardtii chloroplast ClpP complex: additional subunits and structural features.
Plant molecular biology 2012;80(2):189-202.
2012: Anthony J Battisti; Lori W McGinnes; Geng Meng; Trudy G Morrison; Pavel Plevka; Alasdair C Steven; Dennis C Winkler; Michael G Rossmann
Structure and assembly of a paramyxovirus matrix protein.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(35):13996-4000.
2012: Naoko Mizuno; Jobin Varkey; Naiqian Cheng; Balachandra G Hegde; Natalie C Kegulian; Ralf Langen; Alasdair C Steven
Remodeling of lipid vesicles into cylindrical micelles by α-synuclein in an extended α-helical conformation.
The Journal of biological chemistry 2012;287(35):29301-11.
2012: Petra Lukacik; Nicholas Noinaj; Nadir Seddiki; Alasdair C Steven; Kaveri S Chaturvedi; James W Fairman; Jeffrey P Henderson; B Joseph Hinnebusch; Paul W Keller; Tara L Kirby; Travis J Barnard; Susan K Buchanan
Structural engineering of a phage lysin that targets gram-negative pathogens.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(25):9857-62.
2012: Julie Thomas; Susan Weintraub; Dennis C Winkler; Weimin Wu; Naiqian Cheng; Alasdair C Steven; Lindsay W Black
Extensive proteolysis of head and inner body proteins by a morphogenetic protease in the giant Pseudomonas aeruginosa phage φKZ.
Molecular microbiology 2012;84(2):324-39.
2012: Giovanni Cardone; Naiqian Cheng; William W Newcomb; Benes L Trus; Paul T Wingfield; Jay C Brown; Alasdair C Steven
The UL36 tegument protein of herpes simplex virus 1 has a composite binding site at the capsid vertices.
Journal of virology 2012;86(8):4058-64.
2012: Nicholas Noinaj; Muse Oke; Ashley N Steere; Alasdair C Steven; Emadeddin Emadeddin Tajkhorshid; Olga Zak; Nicole C Easley; Robert W Evans; Andrew R Gorringe; James Gumbart; Anne B Mason; Naoko Mizuno; Philip Aisen; Evzen Boura; Susan K Buchanan
Structural basis for iron piracy by pathogenic Neisseria.
Nature 2012;483(7387):53-8.
2012: Juan Fontana; J Bernard Heymann; Giovanni Cardone; Dennis C Winkler; Alasdair C Steven
Structural changes in Influenza virus at low pH characterized by cryo-electron tomography.
Journal of virology 2012;86(6):2919-29.
2012: Hyung Ho Lee; Daniel Nemecek; Christina Schindler; William J Smith; Alasdair C Steven; Juan S Bonifacino; Rodolfo Ghirlando; James H Hurley
Assembly and architecture of biogenesis of lysosome-related organelles complex-1 (BLOC-1).
The Journal of biological chemistry 2012;287(8):5882-90.
2012: Richard Henderson; Wen Jiang; Gerard J Kleywegt; Matthew L Baker; Helen M Berman; Bridget Carragher; Wah Chiu; Batsal Devkota; Kenneth H Downing; Edward H Egelman; Zukang Feng; Joachim Frank; Nikolaus Grigorieff; Steven J Ludtke; Ohad Medalia; Pawel A Penczek; Peter B Rosenthal; Michael G Rossmann; Andrej Sali; Michael F Schmid; Gunnar F Schröder; Alasdair C Steven; David L Stokes; John D Westbrook; Willy Wriggers; Huanwang Yang; Jasmine Young; Catherine L Lawson
Outcome of the first electron microscopy validation task force meeting.
Structure (London, England : 1993) 2012;20(2):205-14.
2012: Weimin Wu; Julie Thomas; Lindsay W Black; Naiqian Cheng; Alasdair C Steven
Bubblegrams reveal the inner body of bacteriophage φKZ.
Science (New York, N.Y.) 2012;335(6065):182.
2012: Giovanni Cardone; Naiqian Cheng; J Bernard Heymann; Benes Trus; Alasdair C Steven
Procapsid assembly, maturation, nuclear exit: dynamic steps in the production of infectious herpesvirions.
Advances in experimental medicine and biology 2012;726():423-39.
2012: Eaazhisai Kandiah; T Jake Liang; Stephen J Stahl; Giovanni Cardone; Naiqian Cheng; Theo Heller; Norman R Watts; Paul T Wingfield; Alasdair C Steven
Cryo-EM study of Hepatitis B virus core antigen capsids decorated with antibodies from a human patient.
Journal of structural biology 2012;177(1):145-51.
2011: Daniel Nemecek; Jian Qiao; Alasdair C Steven; Naiqian Cheng; Leonard Mindich; J Bernard Heymann
Stepwise expansion of the bacteriophage ϕ6 procapsid: possible packaging intermediates.
Journal of molecular biology 2011;414(2):260-71.
2011: Jun Lin; Alasdair C Steven; Naiqian Cheng; Marie Chow; David J Filman; James M Hogle; David M Belnap
An externalized polypeptide partitions between two distinct sites on genome-released poliovirus particles.
Journal of virology 2011;85(19):9974-83.
2011: Surender Khurana; Lisa R King; Christopher Larkin; Jody Manischewitz; William McCormick; Alasdair C Steven; Swati Verma; Juan Fontana; Rajesh K Gupta; Manju B Joshi; Hana Golding
Recombinant HA1 produced in E. coli forms functional oligomers and generates strain-specific SRID potency antibodies for pandemic influenza vaccines.
Vaccine 2011;29(34):5657-65.
2011: Norman R Watts; James F Conway; Naiqian Cheng; Stephen J Stahl; Alasdair C Steven; Paul T Wingfield
Role of the propeptide in controlling conformation and assembly state of hepatitis B virus e-antigen.
Journal of molecular biology 2011;409(2):202-13.
2011: Pavel Plevka; Anthony J Battisti; Jiraphan Junjhon; Dennis C Winkler; Heather A Holdaway; Poonsook Keelapang; Nopporn Sittisombut; Richard J Kuhn; Alasdair C Steven; Michael G Rossmann
Maturation of flaviviruses starts from one or more icosahedrally independent nucleation centres.
EMBO reports 2011;12(6):602-6.
2011: Naoko Mizuno; Ulrich Baxa; Alasdair C Steven
Structural dependence of HET-s amyloid fibril infectivity assessed by cryoelectron microscopy.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(8):3252-7.
2011: Paul W Keller; Catherine S Adamson; J Bernard Heymann; Eric O Freed; Alasdair C Steven
HIV-1 maturation inhibitor bevirimat stabilizes the immature Gag lattice.
Journal of virology 2011;85(4):1420-8.
2011: Ulrich Baxa; Paul W Keller; Naiqian Cheng; Joseph S Wall; Alasdair C Steven
In Sup35p filaments (the [PSI+] prion), the globular C-terminal domains are widely offset from the amyloid fibril backbone.
Molecular microbiology 2011;79(2):523-32.
2011: Claire Goldsbury; Ulrich Baxa; Martha N Simon; Alasdair C Steven; Andreas Engel; Joseph S Wall; Ueli Aebi; Shirley A Müller
Amyloid structure and assembly: insights from scanning transmission electron microscopy.
Journal of structural biology 2011;173(1):1-13.
2010: Ye Xiang; Ulrich Baxa; Ying Zhang; Alasdair C Steven; Gentry L Lewis; James L Van Etten; Michael G Rossmann
Crystal structure of a virus-encoded putative glycosyltransferase.
Journal of virology 2010;84(23):12265-73.
2010: Charlotte Uetrecht; Norman R Watts; Stephen J Stahl; Paul T Wingfield; Alasdair C Steven; Albert J R Heck
Subunit exchange rates in Hepatitis B virus capsids are geometry- and temperature-dependent.
Physical chemistry chemical physics : PCCP 2010;12(41):13368-71.
2010: Jobin Varkey; J Mario Isas; Naoko Mizuno; Martin Borch Jensen; Vikram Kjøller Bhatia; Christine C Jao; Jitka Petrlova; John C Voss; Dimitrios G Stamou; Alasdair C Steven; Ralf Langen
Membrane curvature induction and tubulation are common features of synucleins and apolipoproteins.
The Journal of biological chemistry 2010;285(42):32486-93.
2010: Daniel Nemecek; J Bernard Heymann; Jian Qiao; Leonard Mindich; Alasdair C Steven
Cryo-electron tomography of bacteriophage phi6 procapsids shows random occupancy of the binding sites for RNA polymerase and packaging NTPase.
Journal of structural biology 2010;171(3):389-96.
2010: Naoko Mizuno; Christine C Jao; Ralf Langen; Alasdair C Steven
Multiple modes of endophilin-mediated conversion of lipid vesicles into coated tubes: implications for synaptic endocytosis.
The Journal of biological chemistry 2010;285(30):23351-8.
2010: Carmen Butan; Parvez M Lokhandwala; John Purdy; Giovanni Cardone; Rebecca C Craven; Alasdair C Steven
Suppression of a morphogenic mutant in Rous sarcoma virus capsid protein by a second-site mutation: a cryoelectron tomography study.
Journal of virology 2010;84(13):6377-86.
2010: Norman R Watts; Joe G Vethanayagam; R Bridget Ferns; Richard S Tedder; Audray Harris; Stephen J Stahl; Alasdair C Steven; Paul T Wingfield
Molecular basis for the high degree of antigenic cross-reactivity between hepatitis B virus capsids (HBcAg) and dimeric capsid-related protein (HBeAg): insights into the enigmatic nature of the e-antigen.
Journal of molecular biology 2010;398(4):530-41.
2010: Grégory Effantin; Takashi Ishikawa; Gian Marco De Donatis; Michael R Maurizi; Alasdair C Steven
Local and global mobility in the ClpA AAA+ chaperone detected by cryo-electron microscopy: functional connotations.
Structure (London, England : 1993) 2010;18(5):553-62.
2010: Grégory Effantin; Michael R Maurizi; Alasdair C Steven
Binding of the ClpA unfoldase opens the axial gate of ClpP peptidase.
The Journal of biological chemistry 2010;285(19):14834-40.
2010: Andrey V Kajava; Ulrich Baxa; Alasdair C Steven
Beta arcades: recurring motifs in naturally occurring and disease-related amyloid fibrils.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(5):1311-9.
2010: Stephen J Stahl; Norman R Watts; Christoph Rader; Michael A DiMattia; Rose G Mage; I Palmer; Joshua D Kaufman; Jonathan M Grimes; David I Stuart; Alasdair C Steven; Paul T Wingfield
Generation and characterization of a chimeric rabbit/human Fab for co-crystallization of HIV-1 Rev.
Journal of molecular biology 2010;397(3):697-708.
2010: Michael A DiMattia; Norman R Watts; Stephen J Stahl; Christoph Rader; Paul T Wingfield; David I Stuart; Alasdair C Steven; Jonathan M Grimes
Implications of the HIV-1 Rev dimer structure at 3.2 A resolution for multimeric binding to the Rev response element.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(13):5810-4.
2009: Robert L Duda; Philip D Ross; Naiqian Cheng; Brian A Firek; Roger W Hendrix; James F Conway; Alasdair C Steven
Structure and energetics of encapsidated DNA in bacteriophage HK97 studied by scanning calorimetry and cryo-electron microscopy.
Journal of molecular biology 2009;391(2):471-83.
2009: Peter Adams; Eaazhisai Kandiah; Grégory Effantin; Alasdair C Steven; Ellie Ehrenfeld
Poliovirus 2C protein forms homo-oligomeric structures required for ATPase activity.
The Journal of biological chemistry 2009;284(33):22012-21.
2009: Gabrielle J Grundy; Santiago Ramón-Maiques; Emilios K Dimitriadis; Svetlana Kotova; Christian Biertümpfel; J Bernard Heymann; Alasdair C Steven; Martin Gellert; WEI YANG
Initial stages of V(D)J recombination: the organization of RAG1/2 and RSS DNA in the postcleavage complex.
Molecular cell 2009;35(2):217-27.
2009: Grégory Effantin; Rina Rosenzweig; Michael H Glickman; Alasdair C Steven
Electron microscopic evidence in support of alpha-solenoid models of proteasomal subunits Rpn1 and Rpn2.
Journal of molecular biology 2009;386(5):1204-11.
2009: Giovanni Cardone; John Purdy; Naiqian Cheng; Rebecca C Craven; Alasdair C Steven
Visualization of a missing link in retrovirus capsid assembly.
Nature 2009;457(7230):694-8.
2008: Kelly K Lee; Lu Gan; Hiro Tsuruta; Crystal Moyer; James F Conway; Robert L Duda; Roger W Hendrix; Alasdair C Steven; John E Johnson
Virus capsid expansion driven by the capture of mobile surface loops.
Structure (London, England : 1993) 2008;16(10):1491-502.
2008: Wolfgang Baumeister; Alasdair C Steven
50th anniversary of journal of structural biology.
Journal of structural biology 2008;163(3):185.
2008: Alasdair C Steven; Wolfgang Baumeister
The state of the art.
Journal of structural biology 2008;163(3):201-7.
2008: Alasdair C Steven; Wolfgang Baumeister
The future is hybrid.
Journal of structural biology 2008;163(3):186-95.
2008: Charlotte Uetrecht; Cees Versluis; Norman R Watts; Wouter H Roos; Gijs J L Wuite; Paul T Wingfield; Alasdair C Steven; Albert J R Heck
High-resolution mass spectrometry of viral assemblies: molecular composition and stability of dimorphic hepatitis B virus capsids.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(27):9216-20.
2008: Norman R Watts; Giovanni Cardone; Joe G Vethanayagam; Naiqian Cheng; Catharina Hultgren; Stephen J Stahl; Alasdair C Steven; Matti Sällberg; Paul T Wingfield
Non-canonical binding of an antibody resembling a naïve B cell receptor immunoglobulin to hepatitis B virus capsids.
Journal of molecular biology 2008;379(5):1119-29.
2008: Christopher B Buck; Naiqian Cheng; Cynthia D Thompson; Douglas Lowy; Alasdair C Steven; John T Schiller; Benes Trus
Arrangement of L2 within the papillomavirus capsid.
Journal of virology 2008;82(11):5190-7.
2008: Anindito Sen; J Bernard Heymann; Naiqian Cheng; Jian Qiao; Leonard Mindich; Alasdair C Steven
Initial location of the RNA-dependent RNA polymerase in the bacteriophage Phi6 procapsid determined by cryo-electron microscopy.
The Journal of biological chemistry 2008;283(18):12227-31.
2008: J Bernard Heymann; Giovanni Cardone; Dennis C Winkler; Alasdair C Steven
Computational resources for cryo-electron tomography in Bsoft.
Journal of structural biology 2008;161(3):232-42.
2008: Carmen Butan; Dennis C Winkler; J Bernard Heymann; Rebecca C Craven; Alasdair C Steven
RSV capsid polymorphism correlates with polymerization efficiency and envelope glycoprotein content: implications that nucleation controls morphogenesis.
Journal of molecular biology 2008;376(4):1168-81.
2008: Charlotte Uetrecht; Cees Versluis; Norman R Watts; Paul T Wingfield; Alasdair C Steven; Albert J R Heck
Stability and shape of hepatitis B virus capsids in vacuo.
Angewandte Chemie (International ed. in English) 2008;47(33):6247-51.
2007: Ulrich Baxa; Reed Wickner; Alasdair C Steven; D Eric Anderson; Lyuben Marekov; Wai-Ming Yau; Robert Tycko
Characterization of beta-sheet structure in Ure2p1-89 yeast prion fibrils by solid-state nuclear magnetic resonance.
Biochemistry 2007;46(45):13149-62.
2007: Aitor Hierro; Adriana Rojas; Raul Rojas; Namita Murthy; Grégory Effantin; Andrey V Kajava; Alasdair C Steven; Juan Bonifacino; James H Hurley
Functional architecture of the retromer cargo-recognition complex.
Nature 2007;449(7165):1063-7.
2007: Raimon Sabaté; Ulrich Baxa; Laura Benkemoun; Natalia Sánchez de Groot; Bénédicte Coulary-Salin; Marie-Lise Maddelein; Laurent Malato; Natalia Sánchez de Groot; Alasdair C Steven; Sven J Saupe
Prion and non-prion amyloids of the HET-s prion forming domain.
Journal of molecular biology 2007;370(4):768-83.
2007: Benes Trus; William W Newcomb; Naiqian Cheng; Giovanni Cardone; Lyuben Marekov; Fred Homa; Jay C Brown; Alasdair C Steven
Allosteric signaling and a nuclear exit strategy: binding of UL25/UL17 heterodimers to DNA-Filled HSV-1 capsids.
Molecular cell 2007;26(4):479-89.
2007: Giovanni Cardone; Dennis C Winkler; Benes Trus; Naiqian Cheng; John Edward Heuser; William W Newcomb; Jay C Brown; Alasdair C Steven
Visualization of the herpes simplex virus portal in situ by cryo-electron tomography.
Virology 2007;361(2):426-34.
2007: James F Conway; Naiqian Cheng; Philip D Ross; Roger W Hendrix; Robert L Duda; Alasdair C Steven
A thermally induced phase transition in a viral capsid transforms the hexamers, leaving the pentamers unchanged.
Journal of structural biology 2007;158(2):224-32.
2007: Anindito Sen; Ulrich Baxa; Martha N Simon; Joseph S Wall; Raimon Sabate; Sven J Saupe; Alasdair C Steven
Mass analysis by scanning transmission electron microscopy and electron diffraction validate predictions of stacked beta-solenoid model of HET-s prion fibrils.
The Journal of biological chemistry 2007;282(8):5545-50.
2006: Audray Harris; Giovanni Cardone; Dennis C Winkler; J Bernard Heymann; Matthew Brecher; Judith M White; Alasdair C Steven
Influenza virus pleiomorphy characterized by cryoelectron tomography.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(50):19123-7.
2006: Philip D Ross; James F Conway; Naiqian Cheng; Lindsay Dierkes; Brian A Firek; Roger W Hendrix; Alasdair C Steven; Robert L Duda
A free energy cascade with locks drives assembly and maturation of bacteriophage HK97 capsid.
Journal of molecular biology 2006;364(3):512-25.
2006: Andrey V Kajava; Alasdair C Steven
The turn of the screw: variations of the abundant beta-solenoid motif in passenger domains of Type V secretory proteins.
Journal of structural biology 2006;155(2):306-15.
2006: Alasdair C Steven; Patricia G Spear
Biochemistry. Viral glycoproteins and an evolutionary conundrum.
Science (New York, N.Y.) 2006;313(5784):177-8.
2006: Jérôme Hennetin; Bérangère Jullian; Alasdair C Steven; Andrey V Kajava
Standard conformations of beta-arches in beta-solenoid proteins.
Journal of molecular biology 2006;358(4):1094-105.
2006: William R Wikoff; James F Conway; Jinghua Tang; Kelly K Lee; Lu Gan; Naiqian Cheng; Robert L Duda; Roger W Hendrix; Alasdair C Steven; John E Johnson
Time-resolved molecular dynamics of bacteriophage HK97 capsid maturation interpreted by electron cryo-microscopy and X-ray crystallography.
Journal of structural biology 2006;153(3):300-6.
2006: Audray Harris; David M Belnap; Norman R Watts; James F Conway; Naiqian Cheng; Stephen J Stahl; J G Vethanayagam; Paul T Wingfield; Alasdair C Steven
Epitope diversity of hepatitis B virus capsids: quasi-equivalent variations in spike epitopes and binding of different antibodies to the same epitope.
Journal of molecular biology 2006;355(3):562-76.
2006: Ulrich Baxa; Todd Cassese; Andrey V Kajava; Alasdair C Steven
Structure, function, and amyloidogenesis of fungal prions: filament polymorphism and prion variants.
Advances in protein chemistry 2006;73():125-80.
2006: Andrey V Kajava; Alasdair C Steven
Beta-rolls, beta-helices, and other beta-solenoid proteins.
Advances in protein chemistry 2006;73():55-96.
2005: Giovanni Cardone; Kay Grünewald; Alasdair C Steven
A resolution criterion for electron tomography based on cross-validation.
Journal of structural biology 2005;151(2):117-29.
2005: Doryen Bubeck; David J Filman; Naiqian Cheng; Alasdair C Steven; James M Hogle; David M Belnap
The structure of the poliovirus 135S cell entry intermediate at 10-angstrom resolution reveals the location of an externalized polypeptide that binds to membranes.
Journal of virology 2005;79(12):7745-55.
2005: Andrei Fokine; Petr Leiman; Mikhail M Shneider; Bijan Ahvazi; Karen M Boeshans; Alasdair C Steven; Lindsay W Black; Vadim V Mesyanzhinov; Michael G Rossmann
Structural and functional similarities between the capsid proteins of bacteriophages T4 and HK97 point to a common ancestry.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(20):7163-8.
2005: Ulrich Baxa; Naiqian Cheng; Dennis C Winkler; Thang K Chiu; David Davies; Deepak Sharma; Hideyo Inouye; Daniel A Kirschner; Reed Wickner; Alasdair C Steven
Filaments of the Ure2p prion protein have a cross-beta core structure.
Journal of structural biology 2005;150(2):170-9.
2005: Andrey V Kajava; Ueli Aebi; Alasdair C Steven
The parallel superpleated beta-structure as a model for amyloid fibrils of human amylin.
Journal of molecular biology 2005;348(2):247-52.
2005: Yiyong Li; James F Conway; Naiqian Cheng; Alasdair C Steven; Roger W Hendrix; Robert L Duda
Control of virus assembly: HK97 "Whiffleball" mutant capsids without pentons.
Journal of molecular biology 2005;348(1):167-82.
2005: Philip D Ross; Naiqian Cheng; James F Conway; Brian A Firek; Roger W Hendrix; Robert L Duda; Alasdair C Steven
Crosslinking renders bacteriophage HK97 capsid maturation irreversible and effects an essential stabilization.
The EMBO journal 2005;24(7):1352-63.
2005: Alasdair C Steven; J Bernard Heymann; Naiqian Cheng; Benes Trus; James F Conway
Virus maturation: dynamics and mechanism of a stabilizing structural transition that leads to infectivity.
Current opinion in structural biology 2005;15(2):227-36.
2005: Joaquin Ortega; J Bernard Heymann; Andrey V Kajava; Vicença Ustrell; Martin Rechsteiner; Alasdair C Steven
The axial channel of the 20S proteasome opens upon binding of the PA200 activator.
Journal of molecular biology 2005;346(5):1221-7.
2005: J Bernard Heymann; Kenji Iwasaki; Yang-In Yim; Naiqian Cheng; David M Belnap; Lois E Greene; Evan Eisenberg; Alasdair C Steven
Visualization of the binding of Hsc70 ATPase to clathrin baskets: implications for an uncoating mechanism.
The Journal of biological chemistry 2005;280(8):7156-61.
2005: Michael M Pierce; Ulrich Baxa; Alasdair C Steven; Adriaan Bax; Reed Wickner
Is the prion domain of soluble Ure2p unstructured?
Biochemistry 2005;44(1):321-8.
2005: Alasdair C Steven; James F Conway; Naiqian Cheng; Norman R Watts; David M Belnap; Audray Harris; Stephen J Stahl; Paul T Wingfield
Structure, assembly, and antigenicity of hepatitis B virus capsid proteins.
Advances in virus research 2005;64():125-64.
2005: Andrew J Davison; Benes Trus; Naiqian Cheng; Alasdair C Steven; Moira S Watson; Charles Cunningham; Rose-Marie Le Deuff; Tristan Renault
A novel class of herpesvirus with bivalve hosts.
The Journal of general virology 2005;86(Pt 1):41-53.
2004: Benes Trus; Naiqian Cheng; William W Newcomb; Fred Homa; Jay C Brown; Alasdair C Steven
Structure and polymorphism of the UL6 portal protein of herpes simplex virus type 1.
Journal of virology 2004;78(22):12668-71.
2004: J Bernard Heymann; James F Conway; Alasdair C Steven
Molecular dynamics of protein complexes from four-dimensional cryo-electron microscopy.
Journal of structural biology 2004;147(3):291-301.
2004: Alasdair C Steven
Signal transduction at a protein synapse.
Cell 2004;118(4):403-4.
2004: Takashi Ishikawa; Naiqian Cheng; Xiong Liu; Edward D Korn; Alasdair C Steven
Subdomain organization of the Acanthamoeba myosin IC tail from cryo-electron microscopy.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(33):12189-94.
2004: Lu Gan; James F Conway; Brian A Firek; Naiqian Cheng; Roger W Hendrix; Alasdair C Steven; John E Johnson; Robert L Duda
Control of crosslinking by quaternary structure changes during bacteriophage HK97 maturation.
Molecular cell 2004;14(5):559-69.
2004: Andrey V Kajava; Carlos Gorbea; Joaquín Ortega; Martin Rechsteiner; Alasdair C Steven
New HEAT-like repeat motifs in proteins regulating proteasome structure and function.
Journal of structural biology 2004;146(3):425-30.
2004: Ulrich Baxa; Philip D Ross; Reed Wickner; Alasdair C Steven
The N-terminal prion domain of Ure2p converts from an unfolded to a thermally resistant conformation upon filament formation.
Journal of molecular biology 2004;339(2):259-64.
2004: Andrey V Kajava; Ulrich Baxa; Reed Wickner; Alasdair C Steven
A model for Ure2p prion filaments and other amyloids: the parallel superpleated beta-structure.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(21):7885-90.
2004: Andrey E Kalinin; William Idler; Lyuben Marekov; Peter McPhie; Blair Bowers; Peter M Steinert; Alasdair C Steven
Co-assembly of envoplakin and periplakin into oligomers and Ca(2+)-dependent vesicle binding: implications for cornified cell envelope formation in stratified squamous epithelia.
The Journal of biological chemistry 2004;279(21):22773-80.
2004: Joaquin Ortega; Hyun Sook Lee; Michael R Maurizi; Alasdair C Steven
ClpA and ClpX ATPases bind simultaneously to opposite ends of ClpP peptidase to form active hybrid complexes.
Journal of structural biology 2004;146(1-2):217-26.
2004: Takashi Ishikawa; Michael R Maurizi; Alasdair C Steven
The N-terminal substrate-binding domain of ClpA unfoldase is highly mobile and extends axially from the distal surface of ClpAP protease.
Journal of structural biology 2004;146(1-2):180-8.
2004: Alasdair C Steven; Wolfgang Baumeister
The third man and the fourth paper.
Journal of structural biology 2004;145(3):181-3.
2004: Ulrich Baxa; Kimberly Taylor; Alasdair C Steven; Reed Wickner
Prions of Saccharomyces and Podospora.
Contributions to microbiology 2004;11():50-71.
2003: Shixing Tang; Tsutomu Murakami; Naiqian Cheng; Alasdair C Steven; Eric O Freed; Judith G Levin
Human immunodeficiency virus type 1 N-terminal capsid mutants containing cores with abnormally high levels of capsid protein and virtually no reverse transcriptase.
Journal of virology 2003;77(23):12592-602.
2003: Kay Grünewald; Prashant Desai; Dennis C Winkler; J Bernard Heymann; David M Belnap; Wolfgang Baumeister; Alasdair C Steven
Three-dimensional structure of herpes simplex virus from cryo-electron tomography.
Science (New York, N.Y.) 2003;302(5649):1396-8.
2003: Ulrich Baxa; Kimberly Taylor; Joseph S Wall; Martha N Simon; Naiqian Cheng; Reed Wickner; Alasdair C Steven
Architecture of Ure2p prion filaments: the N-terminal domains form a central core fiber.
The Journal of biological chemistry 2003;278(44):43717-27.
2003: David M Belnap; Norman R Watts; James F Conway; Naiqian Cheng; Stephen J Stahl; Paul T Wingfield; Alasdair C Steven
Diversity of core antigen epitopes of hepatitis B virus.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):10884-9.
2003: James F Conway; Norman R Watts; David M Belnap; Naiqian Cheng; Stephen J Stahl; Paul T Wingfield; Alasdair C Steven
Characterization of a conformational epitope on hepatitis B virus core antigen and quasiequivalent variations in antibody binding.
Journal of virology 2003;77(11):6466-73.
2003: J Bernard Heymann; Naiqian Cheng; William W Newcomb; Benes Trus; Jay C Brown; Alasdair C Steven
Dynamics of herpes simplex virus capsid maturation visualized by time-lapse cryo-electron microscopy.
Nature structural biology 2003;10(5):334-41.
2003: Mario E Cerritelli; Benes Trus; Charles S Smith; Naiqian Cheng; James F Conway; Alasdair C Steven
A second symmetry mismatch at the portal vertex of bacteriophage T7: 8-fold symmetry in the procapsid core.
Journal of molecular biology 2003;327(1):1-6.
2003: Alasdair C Steven; Ueli Aebi
The next ice age: cryo-electron tomography of intact cells.
Trends in cell biology 2003;13(3):107-10.
2003: Mario E Cerritelli; James F Conway; Naiqian Cheng; Benes Trus; Alasdair C Steven
Molecular mechanisms in bacteriophage T7 procapsid assembly, maturation, and DNA containment.
Advances in protein chemistry 2003;64():301-23.
2003: Kay Grünewald; Ohad Medalia; Ariane Gross; Alasdair C Steven; Wolfgang Baumeister
Prospects of electron cryotomography to visualize macromolecular complexes inside cellular compartments: implications of crowding.
Biophysical chemistry 2003;100(1-3):577-91.
2002: Norman R Watts; Naiqian Cheng; Wendy West; Alasdair C Steven; Dan L Sackett
The cryptophycin-tubulin ring structure indicates two points of curvature in the tubulin dimer.
Biochemistry 2002;41(42):12662-9.
2002: Joaquin Ortega; Hyun Sook Lee; Michael R Maurizi; Alasdair C Steven
Alternating translocation of protein substrates from both ends of ClpXP protease.
The EMBO journal 2002;21(18):4938-49.
2002: Naiqian Cheng; Benes Trus; David M Belnap; William W Newcomb; Jay C Brown; Alasdair C Steven
Handedness of the herpes simplex virus capsid and procapsid.
Journal of virology 2002;76(15):7855-9.
2002: Andriy Zakalskiy; Gregor Högenauer; Takashi Ishikawa; Eva Wehrschütz-Sigl; Franz Wendler; David Teis; Gertrude Zisser; Alasdair C Steven; Helmut Bergler
Structural and enzymatic properties of the AAA protein Drg1p from Saccharomyces cerevisiae. Decoupling of intracellular function from ATPase activity and hexamerization.
The Journal of biological chemistry 2002;277(30):26788-95.
2002: Sung Gyun Kang; Joaquin Ortega; Satyendra K Singh; Nan Wang; Ning-Na Huang; Alasdair C Steven; Michael R Maurizi
Functional proteolytic complexes of the human mitochondrial ATP-dependent protease, hClpXP.
The Journal of biological chemistry 2002;277(23):21095-102.
2002: Ester Fernández-Salas; Kwang S Suh; Vladislav V Speransky; Wendy L Bowers; Joshua M Levy; Tracey Adams; Kamal R Pathak; Lindsay E Edwards; Daniel D Hayes; Christina Cheng; Alasdair C Steven; Wendy C Weinberg; Stuart H Yuspa
mtCLIC/CLIC4, an organellular chloride channel protein, is increased by DNA damage and participates in the apoptotic response to p53.
Molecular and cellular biology 2002;22(11):3610-20.
2002: Ulrich Baxa; Vladislav V Speransky; Alasdair C Steven; Reed Wickner
Mechanism of inactivation on prion conversion of the Saccharomyces cerevisiae Ure2 protein.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(8):5253-60.
2002: Norman R Watts; James F Conway; Naiqian Cheng; Stephen J Stahl; David M Belnap; Alasdair C Steven; Paul T Wingfield
The morphogenic linker peptide of HBV capsid protein forms a mobile array on the interior surface.
The EMBO journal 2002;21(5):876-84.
2002: Norman R Watts; Leslie N Jones; Naiqian Cheng; Joseph S Wall; David A D Parry; Alasdair C Steven
Cryo-electron microscopy of trichocyte (hard alpha-keratin) intermediate filaments reveals a low-density core.
Journal of structural biology 2002;137(1-2):109-18.
2002: Michal Jarnik; Pierre A de Viragh; Elisabeth Schärer; Donnie Bundman; Martha N Simon; Dennis R Roop; Alasdair C Steven
Quasi-normal cornified cell envelopes in loricrin knockout mice imply the existence of a loricrin backup system.
The Journal of investigative dermatology 2002;118(1):102-9.
2002: Aixia Zhang; Karen M Wassarman; Joaquin Ortega; Alasdair C Steven; Gisela Storz
The Sm-like Hfq protein increases OxyS RNA interaction with target mRNAs.
Molecular cell 2002;9(1):11-22.
2001: Andrey V Kajava; Naiqian Cheng; R Cleaver; Martin Kessel; Martha N Simon; Eve Willery; Françoise Jacob-Dubuisson; Camille Locht; Alasdair C Steven
Beta-helix model for the filamentous haemagglutinin adhesin of Bordetella pertussis and related bacterial secretory proteins.
Molecular microbiology 2001;42(2):279-92.
2001: Satyendra K Singh; J Rozycki; Joaquin Ortega; T Ishikawa; J Lo; Alasdair C Steven; Michael R Maurizi
Functional domains of the ClpA and ClpX molecular chaperones identified by limited proteolysis and deletion analysis.
The Journal of biological chemistry 2001;276(31):29420-9.
2001: Vladislav V Speransky; Kimberly Taylor; Herman K Edskes; Reed Wickner; Alasdair C Steven
Prion filament networks in [URE3] cells of Saccharomyces cerevisiae.
The Journal of cell biology 2001;153(6):1327-36.
2001: James F Conway; William R Wikoff; Naiqian Cheng; Robert L Duda; Roger W Hendrix; John E Johnson; Alasdair C Steven
Virus maturation involving large subunit rotations and local refolding.
Science (New York, N.Y.) 2001;292(5517):744-8.
2001: T Ishikawa; F Beuron; Martin Kessel; Sue Wickner; Michael R Maurizi; Alasdair C Steven
Translocation pathway of protein substrates in ClpAP protease.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(8):4328-33.
2001: Benes Trus; J Bernard Heymann; K Nealon; Naiqian Cheng; William W Newcomb; Jay C Brown; Dean H Kedes; Alasdair C Steven
Capsid structure of Kaposi's sarcoma-associated herpesvirus, a gammaherpesvirus, compared to those of an alphaherpesvirus, herpes simplex virus type 1, and a betaherpesvirus, cytomegalovirus.
Journal of virology 2001;75(6):2879-90.
2000: T Ishikawa; Michael R Maurizi; David M Belnap; Alasdair C Steven
Docking of components in a bacterial complex.
Nature 2000;408(6813):667-8.
2000: Joaquin Ortega; S K Singh; T Ishikawa; Michael R Maurizi; Alasdair C Steven
Visualization of substrate binding and translocation by the ATP-dependent protease, ClpXP.
Molecular cell 2000;6(6):1515-21.
2000: Wolfgang Baumeister; Alasdair C Steven
Macromolecular electron microscopy in the era of structural genomics.
Trends in biochemical sciences 2000;25(12):624-31.
2000: Y Suga; Michal Jarnik; P S Attar; Mary A Longley; Donnie Bundman; Alasdair C Steven; Peter J Koch; Dennis R Roop
Transgenic mice expressing a mutant form of loricrin reveal the molecular basis of the skin diseases, Vohwinkel syndrome and progressive symmetric erythrokeratoderma.
The Journal of cell biology 2000;151(2):401-12.
2000: Peter J Koch; Pierre A de Viragh; E Scharer; Donnie Bundman; Mary A Longley; Jackie R Bickenbach; Y Kawachi; Y Suga; Zhijian Zhou; Marcel Huber; Daniel Hohl; T Kartasova; Michal Jarnik; Alasdair C Steven; Dennis R Roop
Lessons from loricrin-deficient mice: compensatory mechanisms maintaining skin barrier function in the absence of a major cornified envelope protein.
The Journal of cell biology 2000;151(2):389-400.
2000: Norman R Watts; D L Sackett; R D Ward; M W Miller; Paul T Wingfield; S S Stahl; Alasdair C Steven
HIV-1 rev depolymerizes microtubules to form stable bilayered rings.
The Journal of cell biology 2000;150(2):349-60.
2000: Michael Caffrey; Demetrios T Braddock; John M Louis; M A Abu-Asab; D Kingma; Lance A Liotta; M Tsokos; N Tresser; Lewis K Pannell; N Watts; Alasdair C Steven; Martha N Simon; Stephen J Stahl; Paul T Wingfield; G Marius Clore
Biophysical characterization of gp41 aggregates suggests a model for the molecular mechanism of HIV-associated neurological damage and dementia.
The Journal of biological chemistry 2000;275(26):19877-82.
2000: K Iwasaki; Benes Trus; Paul T Wingfield; Naiqian Cheng; G Campusano; V B Rao; Alasdair C Steven
Molecular architecture of bacteriophage T4 capsid: vertex structure and bimodal binding of the stabilizing accessory protein, Soc.
Virology 2000;271(2):321-33.
2000: Peter Zwickl; Wolfgang Baumeister; Alasdair C Steven
Dis-assembly lines: the proteasome and related ATPase-assisted proteases.
Current opinion in structural biology 2000;10(2):242-50.
2000: Ekaterina G Frank; Naiqian Cheng; C C Do; Mario E Cerritelli; I Bruck; M F Goodman; E H Egelman; Roger Woodgate; Alasdair C Steven
Visualization of two binding sites for the Escherichia coli UmuD'(2)C complex (DNA pol V) on RecA-ssDNA filaments.
Journal of molecular biology 2000;297(3):585-97.
2000: David M Belnap; Alasdair C Steven
'Déjà vu all over again': the similar structures of bacteriophage PRD1 and adenovirus.
Trends in microbiology 2000;8(3):91-3.
2000: F Yang; P Forrer; Z Dauter; James F Conway; Naiqian Cheng; Mario E Cerritelli; Alasdair C Steven; A Plückthun; Alexander Wlodawer
Novel fold and capsid-binding properties of the lambda-phage display platform protein gpD.
Nature structural biology 2000;7(3):230-7.
2000: William W Newcomb; Benes Trus; Naiqian Cheng; Alasdair C Steven; AK Sheaffer; Daniel J Tenney; Sandra K Weller; Jay C Brown
Isolation of herpes simplex virus procapsids from cells infected with a protease-deficient mutant virus.
Journal of virology 2000;74(4):1663-73.
2000: David M Belnap; David J Filman; Benes Trus; Naiqian Cheng; frank booy; James F Conway; S Curry; CN Hiremath; SK Tsang; Alasdair C Steven; James M Hogle
Molecular tectonic model of virus structural transitions: the putative cell entry states of poliovirus.
Journal of virology 2000;74(3):1342-54.
2000: R Lata; James F Conway; Naiqian Cheng; Robert L Duda; Roger W Hendrix; William R Wikoff; John E Johnson; Hiro Tsuruta; Alasdair C Steven
Maturation dynamics of a viral capsid: visualization of transitional intermediate states.
Cell 2000;100(2):253-63.
2000: David M Belnap; Brian M McDermott; David J Filman; Naiqian Cheng; Benes Trus; Harmon J Zuccola; Vincent Racaniello; James M Hogle; Alasdair C Steven
Three-dimensional structure of poliovirus receptor bound to poliovirus.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(1):73-8.
1999: James F Conway; Alasdair C Steven
Methods for reconstructing density maps of "single" particles from cryoelectron micrographs to subnanometer resolution.
Journal of structural biology 1999;128(1):106-18.
1999: Naiqian Cheng; James F Conway; Norman R Watts; James F Hainfeld; V Joshi; Richard D Powell; Stephen J Stahl; P E Wingfield; Alasdair C Steven
Tetrairidium, a four-atom cluster, is readily visible as a density label in three-dimensional cryo-EM maps of proteins at 10-25 A resolution.
Journal of structural biology 1999;127(2):169-76.
1999: Leslie N Jones; M Simon; Norman R Watts; frank booy; Alasdair C Steven; David A D Parry
Intermediate filament structure: hard alpha-keratin.
Experimental dermatology 1999;8(4):310.
1999: William W Newcomb; Fred Homa; Darrell R Thomsen; Benes Trus; Naiqian Cheng; Alasdair C Steven; frank booy; Jay C Brown
Assembly of the herpes simplex virus procapsid from purified components and identification of small complexes containing the major capsid and scaffolding proteins.
Journal of virology 1999;73(5):4239-50.
1999: Jose Caston; David M Belnap; Alasdair C Steven; Benes Trus
A strategy for determining the orientations of refractory particles for reconstruction from cryo-electron micrographs with particular reference to round, smooth-surfaced, icosahedral viruses.
Journal of structural biology 1999;125(2-3):209-15.
1999: Adam Zlotnick; I Palmer; Joshua D Kaufman; Stephen J Stahl; Alasdair C Steven; Paul T Wingfield
Separation and crystallization of T = 3 and T = 4 icosahedral complexes of the hepatitis B virus core protein.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 3):717-20.
1999: Benes Trus; D GIBSON; Naiqian Cheng; Alasdair C Steven
Capsid structure of simian cytomegalovirus from cryoelectron microscopy: evidence for tegument attachment sites.
Journal of virology 1999;73(3):2181-92.
1999: K L Taylor; Naiqian Cheng; R W Williams; Alasdair C Steven; Reed Wickner
Prion domain initiation of amyloid formation in vitro from native Ure2p.
Science (New York, N.Y.) 1999;283(5406):1339-43.
1998: James F Conway; Naiqian Cheng; Adam Zlotnick; Stephen J Stahl; Paul T Wingfield; Alasdair C Steven
Localization of the N terminus of hepatitis B virus capsid protein by peptide-based difference mapping from cryoelectron microscopy.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(25):14622-7.
1998: F Beuron; Michael R Maurizi; David M Belnap; Eva Kocsis; frank booy; Martin Kessel; Alasdair C Steven
At sixes and sevens: characterization of the symmetry mismatch of the ClpAP chaperone-assisted protease.
Journal of structural biology 1998;123(3):248-59.
1998: James F Conway; Naiqian Cheng; Adam Zlotnick; Stephen J Stahl; Paul T Wingfield; David M Belnap; U Kanngiesser; M Noah; Alasdair C Steven
Hepatitis B virus capsid: localization of the putative immunodominant loop (residues 78 to 83) on the capsid surface, and implications for the distinction between c and e-antigens.
Journal of molecular biology 1998;279(5):1111-21.
1998: R Grimaud; Martin Kessel; F Beuron; Alasdair C Steven; Michael R Maurizi
Enzymatic and structural similarities between the Escherichia coli ATP-dependent proteases, ClpXP and ClpAP.
The Journal of biological chemistry 1998;273(20):12476-81.
1998: KA Miroshnikov; EI Marusich; Mario E Cerritelli; Naiqian Cheng; C Hyde; Alasdair C Steven; Vadim V Mesyanzhinov
Engineering trimeric fibrous proteins based on bacteriophage T4 adhesins.
Protein engineering 1998;11(4):329-32.
1998: Michal Jarnik; Martha N Simon; Alasdair C Steven
Cornified cell envelope assembly: a model based on electron microscopic determinations of thickness and projected density.
Journal of cell science 1998;111 ( Pt 8)():1051-60.
1998: Norman R Watts; M Misra; Paul T Wingfield; Stephen J Stahl; Naiqian Cheng; Benes Trus; Alasdair C Steven; R W Williams
Three-dimensional structure of HIV-1 Rev protein filaments.
Journal of structural biology 1998;121(1):41-52.
1997: Paul T Wingfield; Stephen J Stahl; Darrell R Thomsen; Fred Homa; frank booy; Benes Trus; Alasdair C Steven
Hexon-only binding of VP26 reflects differences between the hexon and penton conformations of VP5, the major capsid protein of herpes simplex virus.
Journal of virology 1997;71(12):8955-61.
1997: Mario E Cerritelli; Naiqian Cheng; A H Rosenberg; C E McPherson; frank booy; Alasdair C Steven
Encapsidated conformation of bacteriophage T7 DNA.
Cell 1997;91(2):271-80.
1997: Leslie N Jones; M Simon; Norman R Watts; frank booy; Alasdair C Steven; David A D Parry
Intermediate filament structure: hard alpha-keratin.
Biophysical chemistry 1997;68(1-3):83-93.
1997: Jose Caston; Benes Trus; frank booy; Reed Wickner; Joseph S Wall; Alasdair C Steven
Structure of L-A virus: a specialized compartment for the transcription and replication of double-stranded RNA.
The Journal of cell biology 1997;138(5):975-85.
1997: Adam Zlotnick; Naiqian Cheng; Stephen J Stahl; James F Conway; Alasdair C Steven; Paul T Wingfield
Localization of the C terminus of the assembly domain of hepatitis B virus capsid protein: implications for morphogenesis and organization of encapsidated RNA.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(18):9556-61.
1997: Alasdair C Steven; Benes Trus; frank booy; Naiqian Cheng; Adam Zlotnick; Jose Caston; James F Conway
The making and breaking of symmetry in virus capsid assembly: glimpses of capsid biology from cryoelectron microscopy.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1997;11(10):733-42.
1997: James F Conway; Naiqian Cheng; Adam Zlotnick; Paul T Wingfield; Stephen J Stahl; Alasdair C Steven
Visualization of a 4-helix bundle in the hepatitis B virus capsid by cryo-electron microscopy.
Nature 1997;386(6620):91-4.
1997: JV Spencer; Benes Trus; frank booy; Alasdair C Steven; William W Newcomb; Jay C Brown
Structure of the herpes simplex virus capsid: peptide A862-H880 of the major capsid protein is displayed on the rim of the capsomer protrusions.
Virology 1997;228(2):229-35.
1997: Eva Kocsis; HL Greenstone; E G Locke; Martin Kessel; Alasdair C Steven
Multiple conformational states of the bacteriophage T4 capsid surface lattice induced when expansion occurs without prior cleavage.
Journal of structural biology 1997;118(1):73-82.
1996: Martin Kessel; W Wu; Susan Gottesman; Eva Kocsis; Alasdair C Steven; Michael R Maurizi
Six-fold rotational symmetry of ClpQ, the E. coli homolog of the 20S proteasome, and its ATP-dependent activator, ClpY.
FEBS letters 1996;398(2-3):274-8.
1996: Benes Trus; frank booy; William W Newcomb; Jay C Brown; Fred Homa; Darrell R Thomsen; Alasdair C Steven
The herpes simplex virus procapsid: structure, conformational changes upon maturation, and roles of the triplex proteins VP19c and VP23 in assembly.
Journal of molecular biology 1996;263(3):447-62.
1996: William W Newcomb; Fred Homa; Darrell R Thomsen; frank booy; Benes Trus; Alasdair C Steven; J V Spencer; Jay C Brown
Assembly of the herpes simplex virus capsid: characterization of intermediates observed during cell-free capsid formation.
Journal of molecular biology 1996;263(3):432-46.
1996: Mario E Cerritelli; J S Wall; M N Simon; James F Conway; Alasdair C Steven
Stoichiometry and domainal organization of the long tail-fiber of bacteriophage T4: a hinged viral adhesin.
Journal of molecular biology 1996;260(5):767-80.
1996: Adam Zlotnick; Naiqian Cheng; James F Conway; frank booy; Alasdair C Steven; Stephen J Stahl; Paul T Wingfield
Dimorphism of hepatitis B virus capsids is strongly influenced by the C-terminus of the capsid protein.
Biochemistry 1996;35(23):7412-21.
1996: M Jarnik; T Kartasova; Peter M Steinert; U Lichti; Alasdair C Steven
Differential expression and cell envelope incorporation of small proline-rich protein 1 in different cornified epithelia.
Journal of cell science 1996;109 ( Pt 6)():1381-91.
1996: D V Heck; Benes Trus; Alasdair C Steven
Three-dimensional structure of Bordetella pertussis fimbriae.
Journal of structural biology 1996;116(2):264-9.
1996: frank booy; Benes Trus; A J Davison; Alasdair C Steven
The capsid architecture of channel catfish virus, an evolutionarily distant herpesvirus, is largely conserved in the absence of discernible sequence homology with herpes simplex virus.
Virology 1996;215(2):134-41.
1996: James F Conway; Benes Trus; frank booy; William W Newcomb; Jay C Brown; Alasdair C Steven
Visualization of three-dimensional density maps reconstructed from cryoelectron micrographs of viral capsids.
Journal of structural biology 1996;116(1):200-8.
1996: Benes Trus; Eva Kocsis; James F Conway; Alasdair C Steven
Digital image processing of electron micrographs: the PIC system-III.
Journal of structural biology 1996;116(1):61-7.
1995: Benes Trus; Fred Homa; frank booy; William W Newcomb; Darrell R Thomsen; Naiqian Cheng; Jay C Brown; Alasdair C Steven
Herpes simplex virus capsids assembled in insect cells infected with recombinant baculoviruses: structural authenticity and localization of VP26.
Journal of virology 1995;69(11):7362-6.
1995: James F Conway; Robert L Duda; Naiqian Cheng; Roger W Hendrix; Alasdair C Steven
Proteolytic and conformational control of virus capsid maturation: the bacteriophage HK97 system.
Journal of molecular biology 1995;253(1):86-99.
1995: Eva Kocsis; Mario E Cerritelli; Benes Trus; Naiqian Cheng; Alasdair C Steven
Improved methods for determination of rotational symmetries in macromolecules.
Ultramicroscopy 1995;60(2):219-28.
1995: Martin Kessel; Michael R Maurizi; B Kim; Eva Kocsis; Benes Trus; S K Singh; Alasdair C Steven
Homology in structural organization between E. coli ClpAP protease and the eukaryotic 26 S proteasome.
Journal of molecular biology 1995;250(5):587-94.
1995: Paul T Wingfield; Stephen J Stahl; R W Williams; Alasdair C Steven
Hepatitis core antigen produced in Escherichia coli: subunit composition, conformational analysis, and in vitro capsid assembly.
Biochemistry 1995;34(15):4919-32.
1994: Alexander M Makhov; J H Hannah; M J Brennan; Benes Trus; Eva Kocsis; James F Conway; Paul T Wingfield; M N Simon; Alasdair C Steven
Filamentous hemagglutinin of Bordetella pertussis. A bacterial adhesin formed as a 50-nm monomeric rigid rod based on a 19-residue repeat motif rich in beta strands and turns.
Journal of molecular biology 1994;241(1):110-24.
1994: frank booy; Benes Trus; William W Newcomb; Jay C Brown; James F Conway; Alasdair C Steven
Finding a needle in a haystack: detection of a small protein (the 12-kDa VP26) in a large complex (the 200-MDa capsid of herpes simplex virus).
Proceedings of the National Academy of Sciences of the United States of America 1994;91(12):5652-6.
1994: Alasdair C Steven; Peter M Steinert
Protein composition of cornified cell envelopes of epidermal keratinocytes.
Journal of cell science 1994;107 ( Pt 2)():693-700.
1993: James F Conway; Benes Trus; frank booy; William W Newcomb; Jay C Brown; Alasdair C Steven
The effects of radiation damage on the structure of frozen hydrated HSV-1 capsids.
Journal of structural biology 1993;111(3):222-33.
1993: Eva Kocsis; Benes Trus; Alasdair C Steven; P R Smith; J H Hannah; M J Brennan; Martin Kessel
Orientation of porin channels in the outer membrane of Bordetella pertussis.
Molecular microbiology 1993;9(3):469-76.
1993: William W Newcomb; Benes Trus; frank booy; Alasdair C Steven; J S Wall; Jay C Brown
Structure of the herpes simplex virus capsid. Molecular composition of the pentons and the triplexes.
Journal of molecular biology 1993;232(2):499-511.
1993: J W Mack; Alasdair C Steven; Peter M Steinert
The mechanism of interaction of filaggrin with intermediate filaments. The ionic zipper hypothesis.
Journal of molecular biology 1993;232(1):50-66.
1993: Alexander M Makhov; Benes Trus; James F Conway; M N Simon; T G Zurabishvili; Vadim V Mesyanzhinov; Alasdair C Steven
The short tail-fiber of bacteriophage T4: molecular structure and a mechanism for its conformational transition.
Virology 1993;194(1):117-27.
1992: Alasdair C Steven; HL Greenstone; frank booy; Lindsay W Black; P D Ross
Conformational changes of a viral capsid protein. Thermodynamic rationale for proteolytic regulation of bacteriophage T4 capsid expansion, co-operativity, and super-stabilization by soc binding.
Journal of molecular biology 1992;228(3):870-84.
1992: Benes Trus; William W Newcomb; frank booy; Jay C Brown; Alasdair C Steven
Distinct monoclonal antibodies separately label the hexons or the pentons of herpes simplex virus capsid.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(23):11508-12.
1992: A Aldroubi; Benes Trus; M Unser; frank booy; Alasdair C Steven
Magnification mismatches between micrographs: corrective procedures and implications for structural analysis.
Ultramicroscopy 1992;46(1-4):175-88.
1991: Eva Kocsis; Benes Trus; C J Steer; M E Bisher; Alasdair C Steven
Image averaging of flexible fibrous macromolecules: the clathrin triskelion has an elastic proximal segment.
Journal of structural biology 1991;107(1):6-14.
1991: Paul T Wingfield; Stephen J Stahl; M A Payton; S Venkatesan; M Misra; Alasdair C Steven
HIV-1 Rev expressed in recombinant Escherichia coli: purification, polymerization, and conformational properties.
Biochemistry 1991;30(30):7527-34.
1991: D J Thomas; J S Wall; James F Hainfeld; M Kaczorek; frank booy; Benes Trus; F A Eiserling; Alasdair C Steven
gp160, the envelope glycoprotein of human immunodeficiency virus type 1, is a dimer of 125-kilodalton subunits stabilized through interactions between their gp41 domains.
Journal of virology 1991;65(7):3797-803.
1991: Alasdair C Steven; Eva Kocsis; M Unser; Benes Trus
Spatial disorders and computational cures.
International journal of biological macromolecules 1991;13(3):174-80.
1991: Alasdair C Steven; A C Bauer; M E Bisher; F A Robey; Lindsay W Black
The maturation-dependent conformational change of phage T4 capsid involves the translocation of specific epitopes between the inner and the outer capsid surfaces.
Journal of structural biology 1991;106(3):221-36.
1991: Peter M Steinert; J W Mack; B P Korge; S Q Gan; S R Haynes; Alasdair C Steven
Glycine loops in proteins: their occurrence in certain intermediate filament chains, loricrins and single-stranded RNA binding proteins.
International journal of biological macromolecules 1991;13(3):130-9.
1991: L Thomas; Eva Kocsis; Marco Colombini; E Erbe; Benes Trus; Alasdair C Steven
Surface topography and molecular stoichiometry of the mitochondrial channel, VDAC, in crystalline arrays.
Journal of structural biology 1991;106(2):161-71.
1991: frank booy; William W Newcomb; Benes Trus; Jay C Brown; Timothy S Baker; Alasdair C Steven
Liquid-crystalline, phage-like packing of encapsidated DNA in herpes simplex virus.
Cell 1991;64(5):1007-15.
1990: Alasdair C Steven; M E Bisher; D R Roop; Peter M Steinert
Biosynthetic pathways of filaggrin and loricrin--two major proteins expressed by terminally differentiated epidermal keratinocytes.
Journal of structural biology 1990;104(1-3):150-62.
1990: T Mehrel; Daniel Hohl; Joseph A Rothnagel; M A Longley; Donnie Bundman; C Cheng; U Lichti; M E Bisher; Alasdair C Steven; Peter M Steinert
Identification of a major keratinocyte cell envelope protein, loricrin.
Cell 1990;61(6):1103-12.
1990: Alasdair C Steven; H Greenstone; A C Bauer; R W Williams
The maturation-dependent conformational change of the major capsid protein of bacteriophage T4 involves a substantial change in secondary structure.
Biochemistry 1990;29(23):5556-61.
1989: William W Newcomb; Jay C Brown; frank booy; Alasdair C Steven
Nucleocapsid mass and capsomer protein stoichiometry in equine herpesvirus 1: scanning transmission electron microscopic study.
Journal of virology 1989;63(9):3777-83.
1989: M Unser; Benes Trus; J Frank; Alasdair C Steven
The spectral signal-to-noise ratio resolution criterion: computational efficiency and statistical precision.
Ultramicroscopy 1989;30(3):429-33.
1989: M Unser; Benes Trus; Alasdair C Steven
Normalization procedures and factorial representations for classification of correlation-aligned images: a comparative study.
Ultramicroscopy 1989;30(3):299-310.
1989: Benes Trus; Alasdair C Steven; A W McDowall; M Unser; Jacques Dubochet; R J Podolsky
Interactions between actin and myosin filaments in skeletal muscle visualized in frozen-hydrated thin sections.
Biophysical journal 1989;55(4):713-24.
1988: Michael J Brennan; Z M Li; J L Cowell; M E Bisher; Alasdair C Steven; P Novotny; C R Manclark
Identification of a 69-kilodalton nonfimbrial protein as an agglutinogen of Bordetella pertussis.
Infection and immunity 1988;56(12):3189-95.
1988: M Kessel; Michael J Brennan; Benes Trus; M E Bisher; Alasdair C Steven
Naturally crystalline porin in the outer membrane of Bordetella pertussis.
Journal of molecular biology 1988;203(1):275-8.
1988: Alasdair C Steven; Benes Trus; jacob valentine maizel; M Unser; D A Parry; J S Wall; J F Hainfeld; F W Studier
Molecular substructure of a viral receptor-recognition protein. The gp17 tail-fiber of bacteriophage T7.
Journal of molecular biology 1988;200(2):351-65.
1988: C J Steer; M E Bisher; Benes Trus; J F Hainfeld; J S Wall; Alasdair C Steven
Membrane contents of distinct subpopulations of coated vesicles determined by scanning transmission electron microscopy.
Biochimica et biophysica acta 1988;938(2):167-80.
1987: J L Cowell; J M Zhang; A Urisu; A Suzuki; Alasdair C Steven; T Liu; T Y Liu; C R Manclark
Purification and characterization of serotype 6 fimbriae from Bordetella pertussis and comparison of their properties with serotype 2 fimbriae.
Infection and immunity 1987;55(4):916-22.
1987: M Unser; Benes Trus; Alasdair C Steven
A new resolution criterion based on spectral signal-to-noise ratios.
Ultramicroscopy 1987;23(1):39-51.
1986: Alasdair C Steven; M E Bisher; Benes Trus; D Thomas; J M Zhang; J L Cowell
Helical structure of Bordetella pertussis fimbriae.
Journal of bacteriology 1986;167(3):968-74.
1986: Alasdair C Steven; C R Roberts; J Hay; M E Bisher; T Pun; Benes Trus
Hexavalent capsomers of herpes simplex virus type 2: symmetry, shape, dimensions, and oligomeric status.
Journal of virology 1986;57(2):578-84.
1986: M Unser; Alasdair C Steven; Benes Trus
Odd men out: a quantitative objective procedure for identifying anomalous members of a set of noisy images of ostensibly identical specimens.
Ultramicroscopy 1986;19(4):337-47.
1985: P D Ross; Lindsay W Black; M E Bisher; Alasdair C Steven
Assembly-dependent conformational changes in a viral capsid protein. Calorimetric comparison of successive conformational states of the gp23 surface lattice of bacteriophage T4.
Journal of molecular biology 1985;183(3):353-64.
1985: J M Zhang; J L Cowell; Alasdair C Steven; P H Carter; P P McGrath; C R Manclark
Purification and characterization of fimbriae isolated from Bordetella pertussis.
Infection and immunity 1985;48(2):422-7.
1985: J M Zhang; J L Cowell; Alasdair C Steven; C R Manclark
Purification of serotype 2 fimbriae of Bordetella pertussis and their identification as a mouse protective antigen.
Developments in biological standardization 1985;61():173-85.
1984: C J Steer; M Bisher; R Blumenthal; Alasdair C Steven
Detection of membrane cholesterol by filipin in isolated rat liver coated vesicles is dependent upon removal of the clathrin coat.
The Journal of cell biology 1984;99(1 Pt 1):315-9.
1983: Alasdair C Steven; Philip Serwer; M E Bisher; Benes Trus
Molecular architecture of bacteriophage T7 capsid.
Virology 1983;124(1):109-20.