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Raymond Stevens

Research Profile

Procedures

X Ray Crystallography

Concepts & Ideas

Chemicals & Drugs

Genes & Molecular Sequences

Amino Acid Sequences

Disorders

Phenylketonurias

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Publications

TOP 3
Chong Wang; Huixian Wu; Vadim Cherezov; Gye Won Han; Xi-Ping Huang; Vsevolod Katritch; Wei Liu; Bryan L Roth; Fai Yiu Siu; Raymond C Stevens
Structure of the human smoothened receptor bound to an antitumour agent.
Daniel Wacker; Chong Wang; H Eric Xu; Eyal Vardy; Vadim Cherezov; Meihua Chu; Gye Won Han; Xi-Ping Huang; Yi Jiang; Vsevolod Katritch; Wei Liu; John D McCorvy; Bryan L Roth; Fai Yiu Siu; Raymond C Stevens
Structural features for functional selectivity at serotonin receptors.
Chong Wang; Huixian Wu; Huaiyu Yang; Linlin Yang; Chenghai Zhang; X Edward Zhou; Fang Bai; Vadim Cherezov; Xiang Gao; Gye Won Han; Xi-Ping Huang; Hualiang Jiang; Yi Jiang; Vsevolod Katritch; Wei Liu; Jinming Ma; John D McCorvy; Karsten Melcher; Bryan L Roth; Raymond C Stevens; Eyal Vardy; Daniel Wacker; H Eric Xu
Structural basis for molecular recognition at serotonin receptors.

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All Publications

2013: Chong Wang; Huixian Wu; Vadim Cherezov; Gye Won Han; Xi-Ping Huang; Vsevolod Katritch; Wei Liu; Bryan L Roth; Fai Yiu Siu; Raymond C Stevens
Structure of the human smoothened receptor bound to an antitumour agent.
Nature 2013;497(7449):338-43.
2013: Daniel Wacker; Chong Wang; H Eric Xu; Eyal Vardy; Vadim Cherezov; Meihua Chu; Gye Won Han; Xi-Ping Huang; Yi Jiang; Vsevolod Katritch; Wei Liu; John D McCorvy; Bryan L Roth; Fai Yiu Siu; Raymond C Stevens
Structural features for functional selectivity at serotonin receptors.
Science (New York, N.Y.) 2013;340(6132):615-9.
2013: Chong Wang; Huixian Wu; Huaiyu Yang; Linlin Yang; Chenghai Zhang; X Edward Zhou; Fang Bai; Vadim Cherezov; Xiang Gao; Gye Won Han; Xi-Ping Huang; Hualiang Jiang; Yi Jiang; Vsevolod Katritch; Wei Liu; Jinming Ma; John D McCorvy; Karsten Melcher; Bryan L Roth; Raymond C Stevens; Eyal Vardy; Daniel Wacker; H Eric Xu
Structural basis for molecular recognition at serotonin receptors.
Science (New York, N.Y.) 2013;340(6132):610-4.
2013: Katerina Otrubova; Raymond C Stevens; Monica Brown; Benjamin F Cravatt; Gye W Han; Aron H Lichtman; Michael S McCormick; Scott T O'Neal; Dale L Boger
Rational design of Fatty Acid amide hydrolase inhibitors that act by covalently bonding to two active site residues.
Journal of the American Chemical Society 2013;135(16):6289-99.
2013: Sung Chang Lee; Julien Marcoux; Carol V Robinson; Raymond C Stevens; Charles David Stout; Andrew B Ward; Mark J Yeager; Kent A Baker; Brad C Bennett; Yu Fu; James R Halpert; Wen-Xu Hong; Qinghai Zhang
Steroid-based facial amphiphiles for stabilization and crystallization of membrane proteins.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(13):E1203-11.
2013: David R Webb; Tracy M Handel; Anke Kretz-Rommel; Raymond C Stevens
Opportunities for functional selectivity in GPCR antibodies.
Biochemical pharmacology 2013;85(2):147-52.
2013: Reto Horst; Pawel Stanczak; Raymond C Stevens; Kurt Wüthrich
β2-Adrenergic receptor solutions for structural biology analyzed with microscale NMR diffusion measurements.
Angewandte Chemie (International ed. in English) 2013;52(1):331-5.
2013: Irina Kufareva; Bryan Stephens; Raymond C Stevens; Beili Wu; Ruben Abagyan; Gustavo Fenalti; C Taylor Gilliland; Damon Hamel; Tracy M Handel
A novel approach to quantify g-protein-coupled receptor dimerization equilibrium using bioluminescence resonance energy transfer.
Methods in molecular biology (Clifton, N.J.) 2013;1013():93-127.
2013: Raymond C Stevens; Ruben Abagyan; Vadim Cherezov; Vsevolod Katritch; Peter Kuhn; Hugh Rosen; Kurt Wüthrich
The GPCR Network: a large-scale collaboration to determine human GPCR structure and function.
Nature reviews. Drug discovery 2013;12(1):25-34.
2013: Vsevolod Katritch; Vadim Cherezov; Raymond C Stevens
Structure-function of the G protein-coupled receptor superfamily.
Annual review of pharmacology and toxicology 2013;53():531-56.
2012: Jose S Santos; Raymond C Stevens; Ruhma Syeda; Guillermo A Asmar-Rovira; Kent A Baker; Vadim Cherezov; Gye Won Han; Wei Liu; Mauricio Montal
Crystal structure of a voltage-gated K+ channel pore module in a closed state in lipid membranes.
The Journal of biological chemistry 2012;287(51):43063-70.
2012: Houchao Tao; Aaron Thompson; Yu Fu; Sung Chang Lee; Nicholas Mahoney; Raymond C Stevens; Qinghai Zhang
Synthesis and properties of dodecyl trehaloside detergents for membrane protein studies.
Langmuir : the ACS journal of surfaces and colloids 2012;28(30):11173-81.
2012: Wei Liu; Christopher B Roth; Aaron A Thompson; Fei Xu; Vadim Cherezov; Pavel Chubukov; Eugene Chun; Gye Won Han; Laura H Heitman; Adriaan P IJzerman; Vsevolod Katritch; Raymond C Stevens
Structural basis for allosteric regulation of GPCRs by sodium ions.
Science (New York, N.Y.) 2012;337(6091):232-6.
2012: Eugene Chun; Mark T Griffith; Michael A Hanson; Vsevolod Katritch; Joshua Kunken; Wei Liu; Christopher B Roth; Aaron A Thompson; Fei Xu; Vadim Cherezov; Raymond C Stevens
Fusion partner toolchest for the stabilization and crystallization of G protein-coupled receptors.
Structure (London, England : 1993) 2012;20(6):967-76.
2012: Aaron A Thompson; Claudio Trapella; Eyal Vardy; Huixian Wu; Girolamo Calo; Vadim Cherezov; Eugene Chun; Remo Guerrini; Xi-Ping Huang; Vsevolod Katritch; Wei Liu; Bryan L Roth; Raymond C Stevens
Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic.
Nature 2012;485(7398):395-9.
2012: Huixian Wu; Aaron A Thompson; Eyal Vardy; Daniel Wacker; Richard B Westkaemper; F Ivy Carroll; Vadim Cherezov; Gye Won Han; Xi-Ping Huang; Vsevolod Katritch; Wei Liu; S Wayne Mascarella; Mauro Mileni; Philip D Mosier; Bryan L Roth; Raymond C Stevens
Structure of the human κ-opioid receptor in complex with JDTic.
Nature 2012;485(7398):327-32.
2012: Jeffrey J Liu; Raymond C Stevens; Reto Horst; Vsevolod Katritch; Kurt Wüthrich
Biased signaling pathways in β2-adrenergic receptor characterized by 19F-NMR.
Science (New York, N.Y.) 2012;335(6072):1106-10.
2012: Michael A Hanson; Euijung Jo; Peter Kuhn; Greg Reinhart; Hugh Rosen; Christopher B Roth; M Germana Sanna; Stephen Schuerer; Fiona L Scott; Stuart M Cahalan; Bryan Clemons; Hans Desale; Mark T Griffith; Gye Won Han; Raymond C Stevens
Crystal structure of a lipid G protein-coupled receptor.
Science (New York, N.Y.) 2012;335(6070):851-5.
2012: Christineh N Sarkissian; Patrick Scott; Charles R Scriver; Jerome Dauvillier; Alejandro Dorenbaum; Alejandra Gamez; Raymond C Stevens
Chaperone-like therapy with tetrahydrobiopterin in clinical trials for phenylketonuria: is genotype a predictor of response?
JIMD reports 2012;5():59-70.
2012: Vsevolod Katritch; Vadim Cherezov; Raymond C Stevens
Diversity and modularity of G protein-coupled receptor structures.
Trends in pharmacological sciences 2012;33(1):17-27.
2011: Raymond C Stevens
A roadmap to membrane protein structures.
Methods (San Diego, Calif.) 2011;55(4):271-2.
2011: Aaron A Thompson; Daniel Wacker; Huixian Wu; Vadim Cherezov; Eugene Chun; Jeffrey J Liu; Raymond C Stevens
GPCR stabilization using the bicelle-like architecture of mixed sterol-detergent micelles.
Methods (San Diego, Calif.) 2011;55(4):310-7.
2011: Christineh N Sarkissian; Charles R Scriver; Alejandra Gámez; Tse Siang Kang; Raymond C Stevens
Evaluation of orally administered PEGylated phenylalanine ammonia lyase in mice for the treatment of Phenylketonuria.
Molecular genetics and metabolism 2011;104(3):249-54.
2011: Fei Xu; Raymond C Stevens
Trapping small caffeine in a large GPCR pocket.
Structure (London, England : 1993) 2011;19(9):1204-7.
2011: Irina Kufareva; Manuel Rueda; Raymond C Stevens; Ruben Abagyan; Vsevolod Katritch
Status of GPCR modeling and docking as reflected by community-wide GPCR Dock 2010 assessment.
Structure (London, England : 1993) 2011;19(8):1108-26.
2011: Tatsuro Shimamura; Mitsunori Shiroishi; Raymond C Stevens; Hirokazu Tsujimoto; Simone Weyand; Graeme Winter; Ruben Abagyan; Vadim Cherezov; Gye Won Han; Vsevolod Katritch; Takuya Kobayashi; Wei Liu; So Iwata
Structure of the human histamine H1 receptor complex with doxepin.
Nature 2011;475(7354):65-70.
2011: Meghan T Miller; Raymond C Stevens; Davide Comoletti; Michal Harel; Mauro Mileni; Palmer Taylor
The crystal structure of the α-neurexin-1 extracellular region reveals a hinge point for mediating synaptic adhesion and function.
Structure (London, England : 1993) 2011;19(6):767-78.
2011: Aaron A Thompson; Guan-Sheng Jiao; Seongjin Kim; April Thai; Lynne Cregar-Hernandez; Stephen A Margosiak; Alan T Johnson; Gye Won Han; Sean O'Malley; Raymond C Stevens
Structural characterization of three novel hydroxamate-based zinc chelating inhibitors of the Clostridium botulinum serotype A neurotoxin light chain metalloprotease reveals a compact binding site resulting from 60/70 loop flexibility.
Biochemistry 2011;50(19):4019-28.
2011: Cyrine Ezzili; Mauro Mileni; Nicholas McGlinchey; Jonathan Z Long; Steven G Kinsey; Dustin G Hochstatter; Raymond C Stevens; Aron H Lichtman; Benjamin F Cravatt; Edward J Bilsky; Dale L Boger
Reversible competitive α-ketoheterocycle inhibitors of fatty acid amide hydrolase containing additional conformational constraints in the acyl side chain: orally active, long-acting analgesics.
Journal of medicinal chemistry 2011;54(8):2805-22.
2011: Fei Xu; Huixian Wu; Vsevolod Katritch; Gye Won Han; Kenneth Alan Jacobson; Zhan-Guo Gao; Vadim Cherezov; Raymond C Stevens
Structure of an agonist-bound human A2A adenosine receptor.
Science (New York, N.Y.) 2011;332(6027):322-7.
2011: Mauro Mileni; Joie Garfunkle; Cyrine Ezzili; Benjamin F Cravatt; Raymond C Stevens; Dale L Boger
Fluoride-mediated capture of a noncovalent bound state of a reversible covalent enzyme inhibitor: X-ray crystallographic analysis of an exceptionally potent α-ketoheterocycle inhibitor of fatty acid amide hydrolase.
Journal of the American Chemical Society 2011;133(11):4092-100.
2010: Ellen Y T Chien; Wei Liu; Qiang Zhao; Vsevolod Katritch; Gye Won Han; Michael A Hanson; Lei Shi; Amy Hauck Newman; Jonathan A Javitch; Vadim Cherezov; Raymond C Stevens
Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist.
Science (New York, N.Y.) 2010;330(6007):1091-5.
2010: Beili Wu; Ellen Y T Chien; Clifford D Mol; Gustavo Fenalti; Wei Liu; Vsevolod Katritch; Ruben Abagyan; Alexei Brooun; Peter Wells; F Christopher Bi; Damon J Hamel; Peter Kuhn; Tracy M Handel; Vadim Cherezov; Raymond C Stevens
Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists.
Science (New York, N.Y.) 2010;330(6007):1066-71.
2010: Fai Y Siu; Raymond C Stevens
RAMP-ing up class-B GPCR ECD structural coverage.
Structure (London, England : 1993) 2010;18(9):1067-8.
2010: Daniel Wacker; Gustavo Fenalti; Monica A Brown; Vsevolod Katritch; Ruben Abagyan; Vadim Cherezov; Raymond C Stevens
Conserved binding mode of human beta2 adrenergic receptor inverse agonists and antagonist revealed by X-ray crystallography.
Journal of the American Chemical Society 2010;132(33):11443-5.
2010: Mayako Michino; Jianhan Chen; Raymond C Stevens; Charles L Brooks
FoldGPCR: structure prediction protocol for the transmembrane domain of G protein-coupled receptors from class A.
Proteins 2010;78(10):2189-201.
2010: Mauro Mileni; Satwik Kamtekar; David C Wood; Timothy E Benson; Benjamin F Cravatt; Raymond C Stevens
Crystal structure of fatty acid amide hydrolase bound to the carbamate inhibitor URB597: discovery of a deacylating water molecule and insight into enzyme inactivation.
Journal of molecular biology 2010;400(4):743-54.
2010: Veli-Pekka Jaakola; J Robert Lane; Judy Y Lin; Vsevolod Katritch; Adriaan P IJzerman; Raymond C Stevens
Ligand binding and subtype selectivity of the human A(2A) adenosine receptor: identification and characterization of essential amino acid residues.
The Journal of biological chemistry 2010;285(17):13032-44.
2010: Pål Stenmark; Min Dong; Jérôme Dupuy; Edwin R Chapman; Raymond C Stevens
Crystal structure of the botulinum neurotoxin type G binding domain: insight into cell surface binding.
Journal of molecular biology 2010;397(5):1287-97.
2010: Vsevolod Katritch; Veli-Pekka Jaakola; J Robert Lane; Judy Lin; Adriaan P IJzerman; Mark Yeager; Irina Kufareva; Raymond C Stevens; Ruben Abagyan
Structure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists.
Journal of medicinal chemistry 2010;53(4):1799-809.
2010: Mauro Mileni; Joie Garfunkle; Cyrine Ezzili; F Scott Kimball; Benjamin F Cravatt; Raymond C Stevens; Dale L Boger
X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase.
Journal of medicinal chemistry 2010;53(1):230-40.
2010: Raymond C Stevens; javier sancho; Aurora Martinez
Rescue of misfolded proteins and stabilization by small molecules.
Methods in molecular biology (Clifton, N.J.) 2010;648():313-24.
2010: Vadim Cherezov; Enrique Abola; Raymond C Stevens
Recent progress in the structure determination of GPCRs, a membrane protein family with high potential as pharmaceutical targets.
Methods in molecular biology (Clifton, N.J.) 2010;654():141-68.
2010: Tse Siang Kang; Lin Wang; Christineh N Sarkissian; Alejandra Gámez; Charles R Scriver; Raymond C Stevens
Converting an injectable protein therapeutic into an oral form: phenylalanine ammonia lyase for phenylketonuria.
Molecular genetics and metabolism 2010;99(1):4-9.
2009: Tse Siang Kang; Raymond C Stevens
Structural aspects of therapeutic enzymes to treat metabolic disorders.
Human mutation 2009;30(12):1591-610.
2009: Vadim Cherezov; Michael A Hanson; Mark T Griffith; Mark C Hilgart; Ruslan Sanishvili; Venugopalan Nagarajan; Sergey Stepanov; Robert F Fischetti; Peter Kuhn; Raymond C Stevens
Rastering strategy for screening and centring of microcrystal samples of human membrane proteins with a sub-10 microm size X-ray synchrotron beam.
Journal of the Royal Society, Interface / the Royal Society 2009;6 Suppl 5():S587-97.
2009: Mauro Mileni; Joie Garfunkle; Jessica K DeMartino; Benjamin F Cravatt; Dale L Boger; Raymond C Stevens
Binding and inactivation mechanism of a humanized fatty acid amide hydrolase by alpha-ketoheterocycle inhibitors revealed from cocrystal structures.
Journal of the American Chemical Society 2009;131(30):10497-506.
2009: Mayako Michino; Enrique Abola; Charles L Brooks; J Scott Dixon; John Moult; Raymond C Stevens
Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008.
Nature reviews. Drug discovery 2009;8(6):455-63.
2009: Kay Ahn; Douglas S Johnson; Mauro Mileni; David Beidler; Jonathan Z Long; Michele K McKinney; Eranthie Weerapana; Nalini Sadagopan; Marya Liimatta; Sarah E Smith; Scott Lazerwith; Cory Stiff; Satwik Kamtekar; Keshab Bhattacharya; Yanhua Zhang; Stephen Swaney; Keri Van Becelaere; Raymond C Stevens; Benjamin F Cravatt
Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain.
Chemistry & biology 2009;16(4):411-20.
2009: Michael A Hanson; Raymond C Stevens
Discovery of new GPCR biology: one receptor structure at a time.
Structure (London, England : 1993) 2009;17(1):8-14.
2008: Christineh N Sarkissian; Alejandra Gámez; Lin Wang; Marilyse Charbonneau; Paul Fitzpatrick; Jeffrey F Lemontt; Bin Zhao; Michael Vellard; Sean Bell; Carroll Henschell; Amy Lambert; Laurie Tsuruda; Raymond C Stevens; Charles R Scriver
Preclinical evaluation of multiple species of PEGylated recombinant phenylalanine ammonia lyase for the treatment of phenylketonuria.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(52):20894-9.
2008: Veli-Pekka Jaakola; Mark T Griffith; Michael A Hanson; Vadim Cherezov; Ellen Y T Chien; J Robert Lane; Adriaan P IJzerman; Raymond C Stevens
The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist.
Science (New York, N.Y.) 2008;322(5905):1211-7.
2008: Ian M Slaymaker; Michael Bracey; Mauro Mileni; Joie Garfunkle; Benjamin F Cravatt; Dale L Boger; Raymond C Stevens
Correlation of inhibitor effects on enzyme activity and thermal stability for the integral membrane protein fatty acid amide hydrolase.
Bioorganic & medicinal chemistry letters 2008;18(22):5847-50.
2008: Mauro Mileni; Douglas S Johnson; Zhigang Wang; Daniel S Everdeen; Marya Liimatta; Brandon Pabst; Keshab Bhattacharya; Richard A Nugent; Satwik Kamtekar; Benjamin F Cravatt; Kay Ahn; Raymond C Stevens
Structure-guided inhibitor design for human FAAH by interspecies active site conversion.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(35):12820-4.
2008: Lin Wang; Alejandra Gamez; Holly Archer; Enrique E Abola; Christineh N Sarkissian; Paul Fitzpatrick; Dan Wendt; Yanhong Zhang; Michel Vellard; Joshua Bliesath; Sean Bell; Jeffrey F Lemontt; Charles R Scriver; Raymond C Stevens
Structural and biochemical characterization of the therapeutic Anabaena variabilis phenylalanine ammonia lyase.
Journal of molecular biology 2008;380(4):623-35.
2008: Qinghai Zhang; Reto Horst; Michael Geralt; Xingquan Ma; Wen-Xu Hong; MG Finn; Raymond C Stevens; Kurt Wüthrich
Microscale NMR screening of new detergents for membrane protein structural biology.
Journal of the American Chemical Society 2008;130(23):7357-63.
2008: Michael A Hanson; Vadim Cherezov; Mark T Griffith; Christopher B Roth; Veli-Pekka Jaakola; Ellen Y T Chien; Jeffrey Velasquez; Peter Kuhn; Raymond C Stevens
A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor.
Structure (London, England : 1993) 2008;16(6):897-905.
2008: Benjamin W Neuman; Jeremiah S Joseph; Kumar Singh Saikatendu; Pedro Serrano; Amarnath Chatterjee; Margaret A Johnson; Lujian Liao; Joseph P Klaus; John R Yates; Kurt Wüthrich; Raymond C Stevens; Michael J Buchmeier; Peter Kuhn
Proteomics analysis unravels the functional repertoire of coronavirus nonstructural protein 3.
Journal of virology 2008;82(11):5279-94.
2008: Guillermo A Asmar-Rovira; Aloysha M Asseo-García; Orestes Quesada; Michael A Hanson; Anchi Cheng; Carlos Nogueras; José A Lasalde-Dominicci; Raymond C Stevens
Biophysical and ion channel functional characterization of the Torpedo californica nicotinic acetylcholine receptor in varying detergent-lipid environments.
The Journal of membrane biology 2008;223(1):13-26.
2008: Christopher B Roth; Michael A Hanson; Raymond C Stevens
Stabilization of the human beta2-adrenergic receptor TM4-TM3-TM5 helix interface by mutagenesis of Glu122(3.41), a critical residue in GPCR structure.
Journal of molecular biology 2008;376(5):1305-19.
2008: Alexander I Alexandrov; Mauro Mileni; Ellen Y T Chien; Michael A Hanson; Raymond C Stevens
Microscale fluorescent thermal stability assay for membrane proteins.
Structure (London, England : 1993) 2008;16(3):351-9.
2008: Ralf Jauch; Calista Keow Leng Ng; Kumar Singh Saikatendu; Raymond C Stevens; Prasanna R Kolatkar
Crystal structure and DNA binding of the homeodomain of the stem cell transcription factor Nanog.
Journal of molecular biology 2008;376(3):758-70.
2008: Joseph D Ng; Peter J Clark; Raymond C Stevens; Peter Kuhn
In situ X-ray analysis of protein crystals in low-birefringent and X-ray transmissive plastic microchannels.
Acta crystallographica. Section D, Biological crystallography 2008;64(Pt 2):189-97.
2008: Irimpan I Mathews; Daniel McMullan; Mitchell D Miller; Jaume M Canaves; Marc-André Elsliger; Ross Floyd; Slawomir K Grzechnik; Lukasz Jaroszewski; Heath E Klock; Eric Koesema; John S Kovarik; Andreas Kreusch; Peter Kuhn; Timothy M McPhillips; Andrew T Morse; Kevin Quijano; Christopher L Rife; Robert Schwarzenbacher; Glen Spraggon; Raymond C Stevens; Henry van den Bedem; Dana Weekes; Guenter Wolf; Keith O Hodgson; John Wooley; Ashley M Deacon; Adam Godzik; Scott A Lesley; Ian A Wilson
Crystal structure of 2-keto-3-deoxygluconate kinase (TM0067) from Thermotoga maritima at 2.05 A resolution.
Proteins 2008;70(2):603-8.
2008: Pål Stenmark; Jerome Dupuy; Akihiro Imamura; Makoto Kiso; Raymond C Stevens
Crystal structure of botulinum neurotoxin type A in complex with the cell surface co-receptor GT1b-insight into the toxin-neuron interaction.
PLoS pathogens 2008;4(8):e1000129.
2007: Raymond C Stevens
Generation of protein structures for the 21(st) century.
Structure (London, England : 1993) 2007;15(12):1517-9.
2007: Vadim Cherezov; Daniel M Rosenbaum; Michael A Hanson; Søren G F Rasmussen; Foon Sun Thian; Tong Sun Kobilka; Hee-Jung Choi; Peter Kuhn; William I Weis; Brian K Kobilka; Raymond C Stevens
High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.
Science (New York, N.Y.) 2007;318(5854):1258-65.
2007: Daniel M Rosenbaum; Vadim Cherezov; Michael A Hanson; Søren G F Rasmussen; Foon Sun Thian; Tong Sun Kobilka; Hee-Jung Choi; Xiao-Jie Yao; William I Weis; Raymond C Stevens; Brian K Kobilka
GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function.
Science (New York, N.Y.) 2007;318(5854):1266-73.
2007: Pedro Serrano; Margaret A Johnson; Marcius S Almeida; Reto Horst; Torsten Herrmann; Jeremiah S Joseph; Benjamin W Neuman; Vanitha Subramanian; Kumar Singh Saikatendu; Michael J Buchmeier; Raymond C Stevens; Peter Kuhn; Kurt Wüthrich
Nuclear magnetic resonance structure of the N-terminal domain of nonstructural protein 3 from the severe acute respiratory syndrome coronavirus.
Journal of virology 2007;81(21):12049-60.
2007: Michael A Hanson; Alexei Brooun; Kent A Baker; Veli-Pekka Jaakola; Chris Roth; Ellen Y T Chien; Alexander Alexandrov; Jeffrey Velasquez; Leila Davis; Mark Griffith; Kin Moy; Barbie K Ganser-Pornillos; Yuanzi Hua; Peter Kuhn; Sam Ellis; Mark Yeager; Raymond C Stevens
Profiling of membrane protein variants in a baculovirus system by coupling cell-surface detection with small-scale parallel expression.
Protein expression and purification 2007;56(1):85-92.
2007: Alejandra Gámez; Lin Wang; Christineh N Sarkissian; Dan Wendt; Paul Fitzpatrick; Jeffrey F Lemontt; Charles R Scriver; Raymond C Stevens
Structure-based epitope and PEGylation sites mapping of phenylalanine ammonia-lyase for enzyme substitution treatment of phenylketonuria.
Molecular genetics and metabolism 2007;91(4):325-34.
2007: Jeremiah S Joseph; Kumar Singh Saikatendu; Vanitha Subramanian; Benjamin W Neuman; Michael J Buchmeier; Raymond C Stevens; Peter Kuhn
Crystal structure of a monomeric form of severe acute respiratory syndrome coronavirus endonuclease nsp15 suggests a role for hexamerization as an allosteric switch.
Journal of virology 2007;81(12):6700-8.
2007: Kumar Singh Saikatendu; Jeremiah S Joseph; Vanitha Subramanian; Benjamin W Neuman; Michael J Buchmeier; Raymond C Stevens; Peter Kuhn
Ribonucleocapsid formation of severe acute respiratory syndrome coronavirus through molecular action of the N-terminal domain of N protein.
Journal of virology 2007;81(8):3913-21.
2007: Qinghai Zhang; Xingquan Ma; Andrew Ward; Wen-Xu Hong; Veli-Pekka Jaakola; Raymond C Stevens; MG Finn; Geoffrey A. Chang
Designing facial amphiphiles for the stabilization of integral membrane proteins.
Angewandte Chemie (International ed. in English) 2007;46(37):7023-5.
2007: Lin Wang; Sankar Surendran; Kimberlee Michals-Matalon; Gita Bhatia; Susan Tanskley; Richard Koch; James Grady; Stephen K Tyring; Raymond C Stevens; Flemming Guttler; Reuben Matalon
Mutations in the regulatory domain of phenylalanine hydroxylase and response to tetrahydrobiopterin.
Genetic testing 2007;11(2):174-8.
2007: Consuelo Garcia-Rodriguez; Raphael Levy; Joseph W Arndt; Charles M Forsyth; Ali Razai; Jianlong Lou; Isin Geren; Raymond C Stevens; James D Marks
Molecular evolution of antibody cross-reactivity for two subtypes of type A botulinum neurotoxin.
Nature biotechnology 2007;25(1):107-16.
2006: Qing Chai; Joseph W Arndt; Min Dong; William H Tepp; Eric A Johnson; Edwin R Chapman; Raymond C Stevens
Structural basis of cell surface receptor recognition by botulinum neurotoxin B.
Nature 2006;444(7122):1096-100.
2006: Robert Schwarzenbacher; Daniel McMullan; S Sri Krishna; Qingping Xu; Mitchell D Miller; Jaume M Canaves; Marc-André Elsliger; Ross Floyd; Slawomir K Grzechnik; Lukasz Jaroszewski; Heath E Klock; Eric Koesema; John S Kovarik; Andreas Kreusch; Peter Kuhn; Timothy M McPhillips; Andrew T Morse; Kevin Quijano; Glen Spraggon; Raymond C Stevens; Henry van den Bedem; Guenter Wolf; Keith O Hodgson; John Wooley; Ashley M Deacon; Adam Godzik; Scott A Lesley; Ian A Wilson
Crystal structure of a glycerate kinase (TM1585) from Thermotoga maritima at 2.70 A resolution reveals a new fold.
Proteins 2006;65(1):243-8.
2006: Joseph W Arndt; Mark J Jacobson; Enrique E Abola; Charles M Forsyth; William H Tepp; James D Marks; Eric A Johnson; Raymond C Stevens
A structural perspective of the sequence variability within botulinum neurotoxin subtypes A1-A4.
Journal of molecular biology 2006;362(4):733-42.
2006: Jeremiah S Joseph; Kumar Singh Saikatendu; Vanitha Subramanian; Benjamin W Neuman; Alexei Brooun; Mark Griffith; Kin Moy; Maneesh K Yadav; Jeffrey Velasquez; Michael J Buchmeier; Raymond C Stevens; Peter Kuhn
Crystal structure of nonstructural protein 10 from the severe acute respiratory syndrome coronavirus reveals a novel fold with two zinc-binding motifs.
Journal of virology 2006;80(16):7894-901.
2006: Kiira Ratia; Kumar Singh Saikatendu; Bernard D Santarsiero; Naina Barretto; Susan C Baker; Raymond C Stevens; Andrew D Mesecar
Severe acute respiratory syndrome coronavirus papain-like protease: structure of a viral deubiquitinating enzyme.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(15):5717-22.
2006: Joseph W Arndt; Qing Chai; Todd Christian; Raymond C Stevens
Structure of botulinum neurotoxin type D light chain at 1.65 A resolution: repercussions for VAMP-2 substrate specificity.
Biochemistry 2006;45(10):3255-62.
2005: Bernard Collins; Raymond C Stevens; Rebecca Page
Crystallization Optimum Solubility Screening: using crystallization results to identify the optimal buffer for protein crystal formation.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 12):1035-8.
2005: Wolfgang Peti; Rebecca Page; Kin Moy; Mark O'Neil-Johnson; Ian A Wilson; Raymond C Stevens; Kurt Wüthrich
Towards miniaturization of a structural genomics pipeline using micro-expression and microcoil NMR.
Journal of structural and functional genomics 2005;6(4):259-67.
2005: Reuben Matalon; Kimberlee Michals-Matalon; Richard Koch; James Grady; Stephen Tyring; Raymond C Stevens
Response of patients with phenylketonuria in the US to tetrahydrobiopterin.
Molecular genetics and metabolism 2005;86 Suppl 1():S17-21.
2005: Belén Pérez; Lourdes R Desviat; Paulino Gómez-Puertas; Aurora Martínez; Raymond C Stevens; Magdalena Ugarte
Kinetic and stability analysis of PKU mutations identified in BH4-responsive patients.
Molecular genetics and metabolism 2005;86 Suppl 1():S11-6.
2005: Kumar Singh Saikatendu; Jeremiah S Joseph; Vanitha Subramanian; Tom Clayton; Mark Griffith; Kin Moy; Jeffrey Velasquez; Benjamin W Neuman; Michael J Buchmeier; Raymond C Stevens; Peter Kuhn
Structural basis of severe acute respiratory syndrome coronavirus ADP-ribose-1''-phosphate dephosphorylation by a conserved domain of nsP3.
Structure (London, England : 1993) 2005;13(11):1665-75.
2005: Wolfgang Peti; Margaret A Johnson; Torsten Herrmann; Benjamin W Neuman; Michael J Buchmeier; Mike Nelson; Jeremiah Joseph; Rebecca Page; Raymond C Stevens; Peter Kuhn; Kurt Wüthrich
Structural genomics of the severe acute respiratory syndrome coronavirus: nuclear magnetic resonance structure of the protein nsP7.
Journal of virology 2005;79(20):12905-13.
2005: Joshua S Chappie; Jaume M Cànaves; Gye Won Han; Christopher L Rife; Qingping Xu; Raymond C Stevens
The structure of a eukaryotic nicotinic acid phosphoribosyltransferase reveals structural heterogeneity among type II PRTases.
Structure (London, England : 1993) 2005;13(9):1385-96.
2005: Lin Wang; Alejandra Gamez; Christineh N Sarkissian; Mary Straub; Marianne G Patch; Gye Won Han; Steve Striepeke; Paul Fitzpatrick; Charles R Scriver; Raymond C Stevens
Structure-based chemical modification strategy for enzyme replacement treatment of phenylketonuria.
Molecular genetics and metabolism 2005;86(1-2):134-40.
2005: Joseph W Arndt; Wayne Yu; Fay Bi; Raymond C Stevens
Crystal structure of botulinum neurotoxin type G light chain: serotype divergence in substrate recognition.
Biochemistry 2005;44(28):9574-80.
2005: Alejandra Gámez; Christineh N Sarkissian; Lin Wang; Woomi Kim; Mary Straub; Marianne G Patch; Lin Chen; Steve Striepeke; Paul Fitzpatrick; Jeffrey F Lemontt; Charles O'Neill; Charles R Scriver; Raymond C Stevens
Development of pegylated forms of recombinant Rhodosporidium toruloides phenylalanine ammonia-lyase for the treatment of classical phenylketonuria.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;11(6):986-9.
2005: Joseph W Arndt; Jenny Gu; Lukasz Jaroszewski; Robert Schwarzenbacher; Michael A Hanson; Frank J Lebeda; Raymond C Stevens
The structure of the neurotoxin-associated protein HA33/A from Clostridium botulinum suggests a reoccurring beta-trefoil fold in the progenitor toxin complex.
Journal of molecular biology 2005;346(4):1083-93.
2005: Rebecca Page; Wolfgang Peti; Ian A Wilson; Raymond C Stevens; Kurt Wüthrich
NMR screening and crystal quality of bacterially expressed prokaryotic and eukaryotic proteins in a structural genomics pipeline.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(6):1901-5.
2005: Rebecca Page; Ashley M Deacon; Scott A Lesley; Raymond C Stevens
Shotgun crystallization strategy for structural genomics II: crystallization conditions that produce high resolution structures for T. maritima proteins.
Journal of structural and functional genomics 2005;6(2-3):209-17.
2004: Jaume M Canaves; Rebecca Page; Ian A Wilson; Raymond C Stevens
Protein biophysical properties that correlate with crystallization success in Thermotoga maritima: maximum clustering strategy for structural genomics.
Journal of molecular biology 2004;344(4):977-91.
2004: Heidi Erlandsen; Angel L Pey; Alejandra Gámez; Belén Pérez; Lourdes R Desviat; Cristina Aguado; Richard Koch; Sankar Surendran; Stephen Tyring; Reuben Matalon; Charles R Scriver; Magdalena Ugarte; Aurora Martínez; Raymond C Stevens
Correction of kinetic and stability defects by tetrahydrobiopterin in phenylketonuria patients with certain phenylalanine hydroxylase mutations.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(48):16903-8.
2004: Angel L Pey; Belén Pérez; Lourdes R Desviat; María Angeles Martínez; Cristina Aguado; Heidi Erlandsen; Alejandra Gámez; Raymond C Stevens; Matthías Thórólfsson; Magdalena Ugarte; Aurora Martínez
Mechanisms underlying responsiveness to tetrahydrobiopterin in mild phenylketonuria mutations.
Human mutation 2004;24(5):388-99.
2004: Rebecca Page; Raymond C Stevens
Crystallization data mining in structural genomics: using positive and negative results to optimize protein crystallization screens.
Methods (San Diego, Calif.) 2004;34(3):373-89.
2004: Rebecca Page; Kin Moy; Eric C Sims; Jeffrey Velasquez; Brendan McManus; Carina Grittini; Thomas L Clayton; Raymond C Stevens
Scalable high-throughput micro-expression device for recombinant proteins.
BioTechniques 2004;37(3):364, 366, 368 passim.
2004: Woomi Kim; Heidi Erlandsen; Sankar Surendran; Raymond C Stevens; Alejandra Gamez; Kimberlee Michols-Matalon; Stephen K Tyring; Reuben Matalon
Trends in enzyme therapy for phenylketonuria.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;10(2):220-4.
2004: Zhouxin Shen; Eden P Go; Alejandra Gamez; Junefredo V Apon; Valery V Fokin; Mike Greig; Manuel Ventura; John E Crowell; Ola Blixt; James C Paulson; Raymond C Stevens; MG Finn; Gary Siuzdak
A mass spectrometry plate reader: monitoring enzyme activity and inhibition with a Desorption/Ionization on Silicon (DIOS) platform.
Chembiochem : a European journal of chemical biology 2004;5(7):921-7.
2004: Michael H Bracey; Benjamin F Cravatt; Raymond C Stevens
Structural commonalities among integral membrane enzymes.
FEBS letters 2004;567(2-3):159-65.
2004: Gyorgy Snell; Carl Cork; Robert Nordmeyer; Earl Cornell; George Meigs; Derek Yegian; Joseph Jaklevic; Jian Jin; Raymond C Stevens; Thomas N Earnest
Automated sample mounting and alignment system for biological crystallography at a synchrotron source.
Structure (London, England : 1993) 2004;12(4):537-45.
2004: Raymond C Stevens
Long live structural biology.
Nature structural & molecular biology 2004;11(4):293-5.
2004: Dennis Pantazatos; Jack S Kim; Heath E Klock; Raymond C Stevens; Ian A Wilson; Scott A Lesley; Virgil L Woods
Rapid refinement of crystallographic protein construct definition employing enhanced hydrogen/deuterium exchange MS.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(3):751-6.
2004: Alejandra Gámez; Lin Wang; Mary Straub; Marianne G Patch; Raymond C Stevens
Toward PKU enzyme replacement therapy: PEGylation with activity retention for three forms of recombinant phenylalanine hydroxylase.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;9(1):124-9.
2004: Reuben Matalon; Richard Koch; Kimberlee Michals-Matalon; Kathryn Moseley; Sankar Surendran; Stephen Tyring; Heidi Erlandsen; Alejandra Gamez; Raymond C Stevens; Anne Romstad; Lisbeth Birk Møller; Flemming Guttler
Biopterin responsive phenylalanine hydroxylase deficiency.
Genetics in medicine : official journal of the American College of Medical Genetics 2004;6(1):27-32.
2003: Heidi Erlandsen; Marianne G Patch; Alejandra Gamez; Mary Straub; Raymond C Stevens
Structural studies on phenylalanine hydroxylase and implications toward understanding and treating phenylketonuria.
Pediatrics 2003;112(6 Pt 2):1557-65.
2003: Jun Yin; Albert E. Beuscher; Scott E Andryski; Raymond C Stevens; Peter G Schultz
Structural plasticity and the evolution of antibody affinity and specificity.
Journal of molecular biology 2003;330(4):651-6.
2003: Rebecca Page; Slawomir K Grzechnik; Jaume M Canaves; Glen Spraggon; Andreas Kreusch; Peter Kuhn; Raymond C Stevens; Scott A Lesley
Shotgun crystallization strategy for structural genomics: an optimized two-tiered crystallization screen against the Thermotoga maritima proteome.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 6):1028-37.
2003: David J Hosfield; John Palan; Mark Hilgers; Daniel Scheibe; Duncan E McRee; Raymond C Stevens
A fully integrated protein crystallization platform for small-molecule drug discovery.
Journal of structural biology 2003;142(1):207-17.
2003: Jun Yin; Scott E Andryski; Albert E. Beuscher; Raymond C Stevens; Peter G Schultz
Structural evidence for substrate strain in antibody catalysis.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):856-61.
2003: Mark Weselak; Marianne G Patch; Thomas L Selby; Gunther Knebel; Raymond C Stevens
Robotics for automated crystal formation and analysis.
Methods in enzymology 2003;368():45-76.
2002: Michael H Bracey; Michael A Hanson; Kim R Masuda; Raymond C Stevens; Benjamin F Cravatt
Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling.
Science (New York, N.Y.) 2002;298(5599):1793-6.
2002: Lin Wang; Heidi Erlandsen; Jan Haavik; Per M Knappskog; Raymond C Stevens
Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin.
Biochemistry 2002;41(42):12569-74.
2002: Peter Kuhn; Keith Wilson; Marianne G Patch; Raymond C Stevens
The genesis of high-throughput structure-based drug discovery using protein crystallography.
Current opinion in chemical biology 2002;6(5):704-10.
2002: Scott A Lesley; Peter Kuhn; Adam Godzik; Ashley M Deacon; Irimpan I Mathews; Andreas Kreusch; Glen Spraggon; Heath E Klock; Daniel McMullan; Tanya Shin; Juli Vincent; Alyssa Robb; Linda S Brinen; Mitchell D Miller; Timothy M McPhillips; Mark A Miller; Daniel Scheibe; Jaume M Canaves; Chittibabu Guda; Lukasz Jaroszewski; Thomas L Selby; Marc-André Elsliger; John Wooley; Susan S Taylor; Keith O Hodgson; Ian A Wilson; Peter G Schultz; Raymond C Stevens
Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(18):11664-9.
2002: Heidi Erlandsen; Joo Y Kim; Marianne G Patch; Aidong Han; Alon Volner; Mahdi M Abu-Omar; Raymond C Stevens
Structural comparison of bacterial and human iron-dependent phenylalanine hydroxylases: similar fold, different stability and reaction rates.
Journal of molecular biology 2002;320(3):645-61.
2001: Raymond C Stevens; S Yokoyama; Ian A Wilson
Global efforts in structural genomics.
Science (New York, N.Y.) 2001;294(5540):89-92.
2001: Jun Yin; EC Mundorff; P L Yang; K. Ulrich wendt; Denise Hanway; Raymond C Stevens; Peter G Schultz
A comparative analysis of the immunological evolution of antibody 28B4.
Biochemistry 2001;40(36):10764-73.
2001: Heidi Erlandsen; Raymond C Stevens
A structural hypothesis for BH4 responsiveness in patients with mild forms of hyperphenylalaninaemia and phenylketonuria.
Journal of inherited metabolic disease 2001;24(2):213-30.
2001: D W Chen; Albert E. Beuscher; Raymond C Stevens; Peter Wirsching; Richard A Lerner; Kim D Janda
Preparation of stilbene-tethered nonnatural nucleosides for use with blue-fluorescent antibodies.
The Journal of organic chemistry 2001;66(5):1725-32.
2001: M C Orencia; J S Yoon; Jon E Ness; Willem P C Stemmer; Raymond C Stevens
Predicting the emergence of antibiotic resistance by directed evolution and structural analysis.
Nature structural biology 2001;8(3):238-42.
2000: J P Rogers; P Luginbühl; K Pemberton; P Harty; David E Wemmer; Raymond C Stevens
Structure-activity relationships in a peptidic alpha7 nicotinic acetylcholine receptor antagonist.
Journal of molecular biology 2000;304(5):911-26.
2000: Heidi Erlandsen; Enrique E Abola; Raymond C Stevens
Combining structural genomics and enzymology: completing the picture in metabolic pathways and enzyme active sites.
Current opinion in structural biology 2000;10(6):719-30.
2000: Enrique E Abola; P Kuhn; T Earnest; Raymond C Stevens
Automation of X-ray crystallography.
Nature structural biology 2000;7 Suppl():973-7.
2000: A Simeonov; Masayuki Matsushita; E A Juban; Elizabeth H Z Thompson; Timothy Z Hoffman; Albert E. Beuscher; M J Taylor; Peter Wirsching; W Rettig; James K McCusker; Raymond C Stevens; David P Millar; Peter G Schultz; Richard A Lerner; Kim D Janda
Blue-fluorescent antibodies.
Science (New York, N.Y.) 2000;290(5490):307-13.
2000: Raymond C Stevens
High-throughput protein crystallization.
Current opinion in structural biology 2000;10(5):558-63.
2000: Raymond C Stevens
Design of high-throughput methods of protein production for structural biology.
Structure (London, England : 1993) 2000;8(9):R177-85.
2000: Michael A Hanson; Raymond C Stevens
Cocrystal structure of synaptobrevin-II bound to botulinum neurotoxin type B at 2.0 A resolution.
Nature structural biology 2000;7(8):687-92.
2000: Heidi Erlandsen; Elisa Bjørgo; Torgeir Flatmark; Raymond C Stevens
Crystal structure and site-specific mutagenesis of pterin-bound human phenylalanine hydroxylase.
Biochemistry 2000;39(9):2208-17.
2000: EC Mundorff; M A Hanson; A Varvak; HD Ulrich; Peter G Schultz; Raymond C Stevens
Conformational effects in biological catalysis: an antibody-catalyzed oxy-cope rearrangement.
Biochemistry 2000;39(4):627-32.
2000: M C Orencia; M A Hanson; Raymond C Stevens
Structural analysis of affinity matured antibodies and laboratory-evolved enzymes.
Advances in protein chemistry 2000;55():227-59.
1999: Benjamin W Spiller; A Gershenson; F H Arnold; Raymond C Stevens
A structural view of evolutionary divergence.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(22):12305-10.
1999: Heidi Erlandsen; Raymond C Stevens
The structural basis of phenylketonuria.
Molecular genetics and metabolism 1999;68(2):103-25.
1999: D B Lacy; Raymond C Stevens
Sequence homology and structural analysis of the clostridial neurotoxins.
Journal of molecular biology 1999;291(5):1091-104.
1999: Bostjan Kobe; Ian G Jennings; CM House; Belinda J Michell; KE Goodwill; Bernard D Santarsiero; Raymond C Stevens; Richard G H Cotton; Bruce E Kemp
Structural basis of autoregulation of phenylalanine hydroxylase.
Nature structural biology 1999;6(5):442-8.
1999: J P Rogers; P Luginbühl; G S Shen; RT McCabe; Raymond C Stevens; David E Wemmer
NMR solution structure of alpha-conotoxin ImI and comparison to other conotoxins specific for neuronal nicotinic acetylcholine receptors.
Biochemistry 1999;38(13):3874-82.
1998: Heidi Erlandsen; Torgeir Flatmark; Raymond C Stevens; Edward Hough
Crystallographic analysis of the human phenylalanine hydroxylase catalytic domain with bound catechol inhibitors at 2.0 A resolution.
Biochemistry 1998;37(45):15638-46.
1998: FE Romesberg; Bernard D Santarsiero; Benjamin W Spiller; Jun Yin; D Barnes; Peter G Schultz; Raymond C Stevens
Structural and kinetic evidence for strain in biological catalysis.
Biochemistry 1998;37(41):14404-9.
1998: Elisa Bjørgo; Per M Knappskog; Aurora Martinez; Raymond C Stevens; Torgeir Flatmark
Partial characterization and three-dimensional-structural localization of eight mutations in exon 7 of the human phenylalanine hydroxylase gene associated with phenylketonuria.
European journal of biochemistry / FEBS 1998;257(1):1-10.
1998: D B Lacy; William H Tepp; A C Cohen; Bibhuti R Dasgupta; Raymond C Stevens
Crystal structure of botulinum neurotoxin type A and implications for toxicity.
Nature structural biology 1998;5(10):898-902.
1998: KE Goodwill; C Sabatier; Raymond C Stevens
Crystal structure of tyrosine hydroxylase with bound cofactor analogue and iron at 2.3 A resolution: self-hydroxylation of Phe300 and the pterin-binding site.
Biochemistry 1998;37(39):13437-45.
1998: F Fusetti; Heidi Erlandsen; Torgeir Flatmark; Raymond C Stevens
Structure of tetrameric human phenylalanine hydroxylase and its implications for phenylketonuria.
The Journal of biological chemistry 1998;273(27):16962-7.
1998: B Andersen; Raymond C Stevens
The human D1A dopamine receptor: heterologous expression in Saccharomyces cerevisiae and purification of the functional receptor.
Protein expression and purification 1998;13(1):111-9.
1998: F Chen; GM Kuziemko; Raymond C Stevens
Biophysical characterization of the stability of the 150-kilodalton botulinum toxin, the nontoxic component, and the 900-kilodalton botulinum toxin complex species.
Infection and immunity 1998;66(6):2420-5.
1998: FE Romesberg; Benjamin W Spiller; Peter G Schultz; Raymond C Stevens
Immunological origins of binding and catalysis in a Diels-Alderase antibody.
Science (New York, N.Y.) 1998;279(5358):1929-33.
1997: Heidi Erlandsen; F Fusetti; A Martinez; Edward Hough; Torgeir Flatmark; Raymond C Stevens
Crystal structure of the catalytic domain of human phenylalanine hydroxylase reveals the structural basis for phenylketonuria.
Nature structural biology 1997;4(12):995-1000.
1997: D B Lacy; Raymond C Stevens
Recombinant expression and purification of the botulinum neurotoxin type A translocation domain.
Protein expression and purification 1997;11(2):195-200.
1997: F Burkard; F Chen; GM Kuziemko; Raymond C Stevens
Electron density projection map of the botulinum neurotoxin 900-kilodalton complex by electron crystallography.
Journal of structural biology 1997;120(1):78-84.
1997: HD Ulrich; EC Mundorff; Bernard D Santarsiero; E M Driggers; Raymond C Stevens; Peter G Schultz
The interplay between binding energy and catalysis in the evolution of a catalytic antibody.
Nature 1997;389(6648):271-5.
1997: KE Goodwill; C Sabatier; C Marks; R Raag; P F Fitzpatrick; Raymond C Stevens
Crystal structure of tyrosine hydroxylase at 2.3 A and its implications for inherited neurodegenerative diseases.
Nature structural biology 1997;4(7):578-85.
1997: Gary J Wedemayer; P A Patten; L H Wang; Peter G Schultz; Raymond C Stevens
Structural insights into the evolution of an antibody combining site.
Science (New York, N.Y.) 1997;276(5319):1665-9.
1997: Gary J Wedemayer; L H Wang; P A Patten; Peter G Schultz; Raymond C Stevens
Crystal structures of the free and liganded form of an esterolytic catalytic antibody.
Journal of molecular biology 1997;268(2):390-400.
1997: F Chen; GM Kuziemko; Peter Amersdorfer; Cindy Wong; James D Marks; Raymond C Stevens
Antibody mapping to domains of botulinum neurotoxin serotype A in the complexed and uncomplexed forms.
Infection and immunity 1997;65(5):1626-30.
1996: Linda C Hsieh-Wilson; Peter G Schultz; Raymond C Stevens
Insights into antibody catalysis: structure of an oxygenation catalyst at 1.9-angstrom resolution.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(11):5363-7.
1996: G M Kuziemko; M Stroh; Raymond C Stevens
Cholera toxin binding affinity and specificity for gangliosides determined by surface plasmon resonance.
Biochemistry 1996;35(20):6375-84.
1996: P A Patten; Nathanael S Gray; P L Yang; C B Marks; Gary J Wedemayer; J J Boniface; Raymond C Stevens; Peter G Schultz
The immunological evolution of catalysis.
Science (New York, N.Y.) 1996;271(5252):1086-91.
1996: D Charych; Q Cheng; A Reichert; G Kuziemko; M Stroh; J O Nagy; W Spevak; Raymond C Stevens
A 'litmus test' for molecular recognition using artificial membranes.
Chemistry & biology 1996;3(2):113-20.