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Freda Stevenson

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Freda K Stevenson; George T Stevenson
Follicular lymphoma and the immune system: from pathogenesis to antibody therapy.
Francesco Forconi; Gianluca Gaidano; Valter Gattei; Isla Henderson; Graham Packham; Kathleen N Potter; Davide Rossi; Elisa Sozzi; Riccardo Bomben; Emanuele Cencini; Freda K Stevenson
The IGHV1-69/IGHJ3 recombinations of unmutated CLL are distinct from those of normal B cells.
Alex Paterson; Kathleen N Potter; Freda K Stevenson; Jemimah E Adams; Simon J Cook; Andrew S Duncombe; Sergey Krysov; C Ian Mockridge; Graham Packham
Mechanisms and clinical significance of BIM phosphorylation in chronic lymphocytic leukemia.

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All Publications

2012: Freda K Stevenson; George T Stevenson
Follicular lymphoma and the immune system: from pathogenesis to antibody therapy.
Blood 2012;119(16):3659-67.
2012: Francesco Forconi; Gianluca Gaidano; Valter Gattei; Isla Henderson; Graham Packham; Kathleen N Potter; Davide Rossi; Elisa Sozzi; Riccardo Bomben; Emanuele Cencini; Freda K Stevenson
The IGHV1-69/IGHJ3 recombinations of unmutated CLL are distinct from those of normal B cells.
Blood 2012;119(9):2106-9.
2012: Alex Paterson; Kathleen N Potter; Freda K Stevenson; Jemimah E Adams; Simon J Cook; Andrew S Duncombe; Sergey Krysov; C Ian Mockridge; Graham Packham
Mechanisms and clinical significance of BIM phosphorylation in chronic lymphocytic leukemia.
Blood 2012;119(7):1726-36.
2011: Freda K Stevenson; Andrew J Steele; Andrew J Davies; Sergey Krysov; Graham Packham
B-cell receptor signaling in chronic lymphocytic leukemia.
Blood 2011;118(16):4313-20.
2011: Freda K Stevenson; Lindsey Chudley; Ann Mander; Christian H Ottensmeier
DNA fusion vaccines enter the clinic.
Cancer immunology, immunotherapy : CII 2011;60(8):1147-51.
2011: Gisella E Vittes; Elena L Harden; Christian H Ottensmeier; Jason Rice; Freda K Stevenson
DNA fusion gene vaccines induce cytotoxic T-cell attack on naturally processed peptides of human prostate-specific membrane antigen.
European journal of immunology 2011;41(8):2447-56.
2011: Natalia Savelyeva; Michael Shipton; Gavin Babbage; Amy Suchacki; Freda K Stevenson
High-affinity memory B cells induced by conjugate vaccines against weak tumor antigens are vulnerable to nonconjugated antigen.
Blood 2011;118(3):650-9.
2010: Neta S Zuckerman; Katy J McCann; Christian H Ottensmeier; Michal Barak; Gitit Shahaf; Hanna Edelman; Deborah K Dunn-Walters; Roshini S Abraham; Freda K Stevenson; Ramit Mehr
Ig gene diversification and selection in follicular lymphoma, diffuse large B cell lymphoma and primary central nervous system lymphoma revealed by lineage tree and mutation analyses.
International immunology 2010;22(11):875-87.
2010: Vania Coelho; Sergey Krysov; Amir M Ghaemmaghami; Mohamed Emara; Kathleen N Potter; Peter Johnson; Graham Packham; Luisa Martinez-Pomares; Freda K Stevenson
Glycosylation of surface Ig creates a functional bridge between human follicular lymphoma and microenvironmental lectins.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(43):18587-92.
2010: Freda K Stevenson; Peter W M Johnson
Harnessing innate immunity to suppress lymphoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(28):4295-6.
2010: Sergey Krysov; Kathleen N Potter; C Ian Mockridge; Vania Coelho; Isla Wheatley; Graham Packham; Freda K Stevenson
Surface IgM of CLL cells displays unusual glycans indicative of engagement of antigen in vivo.
Blood 2010;115(21):4198-205.
2010: Freda K Stevenson; Karolina Palucka
Understanding and activating immunity against human cancer.
Current opinion in immunology 2010;22(2):212-4.
2010: Freda K Stevenson; Christian H Ottensmeier; Jason Rice
DNA vaccines against cancer come of age.
Current opinion in immunology 2010;22(2):264-70.
2010: Francesco Forconi; Kathleen N Potter; Isla Wheatley; Nikos Darzentas; Elisa Sozzi; Kostas Stamatopoulos; C Ian Mockridge; Graham Packham; Freda K Stevenson
The normal IGHV1-69-derived B-cell repertoire contains stereotypic patterns characteristic of unmutated CLL.
Blood 2010;115(1):71-7.
2009: Caleb G Chen; Yen-Ta Lu; Marie Lin; Natalia Savelyeva; Freda K Stevenson; Delin Zhu
Amplification of immune responses against a DNA-delivered idiotypic lymphoma antigen by fusion to the B subunit of E. coli heat labile toxin.
Vaccine 2009;27(32):4289-96.
2009: Katy J McCann; Margaret Ashton-Key; Kellyann Smith; Freda K Stevenson; Christian H Ottensmeier
Primary central nervous system lymphoma: tumor-related clones exist in the blood and bone marrow with evidence for separate development.
Blood 2009;113(19):4677-80.
2008: Coralie Chaise; Sarah L Buchan; Jason Rice; Jeanine Marquet; Hélène Rouard; Mathieu Kuentz; Gisella E Vittes; Valérie Molinier-Frenkel; Jean-Pierre Farcet; Hans J Stauss; Marie-Hélène Delfau-Larue; Freda K Stevenson
DNA vaccination induces WT1-specific T-cell responses with potential clinical relevance.
Blood 2008;112(7):2956-64.
2008: Jason Rice; Michelle L Dossett; Claes Ohlén; Sarah L Buchan; Timothy Kendall; Stuart N Dunn; Freda K Stevenson; Philip D Greenberg
DNA fusion gene vaccination mobilizes effective anti-leukemic cytotoxic T lymphocytes from a tolerized repertoire.
European journal of immunology 2008;38(8):2118-30.
2008: Katy J McCann; Christian H Ottensmeier; Alice Callard; Catherine M Radcliffe; David Harvey; Raymond A Dwek; Pauline M Rudd; Brian J Sutton; Paul Hobby; Freda K Stevenson
Remarkable selective glycosylation of the immunoglobulin variable region in follicular lymphoma.
Molecular immunology 2008;45(6):1567-72.
2008: Jason Rice; Christian H Ottensmeier; Freda K Stevenson
DNA vaccines: precision tools for activating effective immunity against cancer.
Nature reviews. Cancer 2008;8(2):108-20.
2008: Stephen M Thirdborough; Joanne S Roddick; Joanna N Radcliffe; Mark Howarth; Freda K Stevenson; Tim Elliott
Tapasin shapes immunodominance hierarchies according to the kinetic stability of peptide-MHC class I complexes.
European journal of immunology 2008;38(2):364-9.
2008: Anna L Furmanski; Cristina Ferreira; Istvan Bartok; Sofia Dimakou; Jason Rice; Freda K Stevenson; Maggie Millrain; Elizabeth Simpson; Julian Dyson
Public T cell receptor beta-chains are not advantaged during positive selection.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(2):1029-39.
2008: Delin Zhu; Jeannette Williams; Jason Rice; Freda K Stevenson; John E Heckels; Myron Christodoulides
A DNA fusion vaccine induces bactericidal antibodies to a peptide epitope from the PorA porin of Neisseria meningitidis.
Infection and immunity 2008;76(1):334-8.
2007: Joanna N Radcliffe; Joanne S Roddick; Freda K Stevenson; Stephen M Thirdborough
Prolonged antigen expression following DNA vaccination impairs effector CD8+ T cell function and memory development.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(12):8313-21.
2007: C Ian Mockridge; Kathleen N Potter; Isla Wheatley; Louise A Neville; Graham Packham; Freda K Stevenson
Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by VH-gene mutational status.
Blood 2007;109(10):4424-31.
2007: Gavin Babbage; M Townsend; Niklas Zojer; I C Mockridge; Richard Garand; Bart Barlogie; J Shaughnessy; Freda K Stevenson; Surinder S Sahota
IgM-expressing Waldenstrom's macroglobulinemia tumor cells reveal a potential for isotype switch events in vivo.
Leukemia 2007;21(4):827-30.
2007: Catherine M Radcliffe; James N Arnold; David M Suter; Mark R Wormald; David Harvey; Louise Royle; Yusuke Mimura; Yoshinobu Kimura; Robert B Sim; Susana Inogès; Mercedes Rodriguez-Calvillo; Natalia Zabalegui; Ascensión López-Díaz de Cerio; Kathleen N Potter; C Ian Mockridge; Raymond A Dwek; Maurizio Bendandi; Pauline M Rudd; Freda K Stevenson
Human follicular lymphoma cells contain oligomannose glycans in the antigen-binding site of the B-cell receptor.
The Journal of biological chemistry 2007;282(10):7405-15.
2007: Becky M Pickering; S de Mel; M Lee; M Howell; Fay Habens; Claire L Dallman; Louise A Neville; Kathleen N Potter; J Mann; Derek A Mann; Peter WM Johnson; Freda K Stevenson; Graham Packham
Pharmacological inhibitors of NF-kappaB accelerate apoptosis in chronic lymphocytic leukaemia cells.
Oncogene 2007;26(8):1166-77.
2006: Surinder S Sahota; C Madusha Goonewardena; Christopher D O Cooper; Amanda P Liggins; Kamal Ait-Tahar; Niklas Zojer; Freda K Stevenson; Alison H Banham; Karen Pulford
PASD1 is a potential multiple myeloma-associated antigen.
Blood 2006;108(12):3953-5.
2006: Joanna N Radcliffe; Joanne S Roddick; Peter S Friedmann; Freda K Stevenson; Stephen M Thirdborough
Prime-boost with alternating DNA vaccines designed to engage different antigen presentation pathways generates high frequencies of peptide-specific CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(10):6626-33.
2006: Surinder Singh Sahota; Freda K Stevenson
Lineage complexity in multiple myeloma?
Leukemia & lymphoma 2006;47(9):1997-8.
2006: Jason Rice; Stuart Dunn; Karen Piper; Sarah Buchan; Paul A Moss; Freda K Stevenson
DNA fusion vaccines induce epitope-specific cytotoxic CD8(+) T cells against human leukemia-associated minor histocompatibility antigens.
Cancer research 2006;66(10):5436-42.
2006: Freda K Stevenson; Jason Rice
Optimizing cancer immunotherapy trials: back to basics.
European journal of immunology 2006;36(5):1070-3.
2006: Gavin Babbage; Christian H Ottensmeier; Jeremy P Blaydes; Freda K Stevenson; Surinder S Sahota
Immunoglobulin heavy chain locus events and expression of activation-induced cytidine deaminase in epithelial breast cancer cell lines.
Cancer research 2006;66(8):3996-4000.
2006: Gianfranco Di Genova; Joanna Roddick; Feargal McNicholl; Freda K Stevenson
Vaccination of human subjects expands both specific and bystander memory T cells but antibody production remains vaccine specific.
Blood 2006;107(7):2806-13.
2006: Kathleen N Potter; C Ian Mockridge; Louise A Neville; Isla Wheatley; Michael Schenk; Jennifer Orchard; Andrew S Duncombe; Graham Packham; Freda K Stevenson
Structural and functional features of the B-cell receptor in IgG-positive chronic lymphocytic leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(6):1672-9.
2006: Katy J McCann; P W M Johnson; Freda K Stevenson; Christian H Ottensmeier
Universal N-glycosylation sites introduced into the B-cell receptor of follicular lymphoma by somatic mutation: a second tumorigenic event?
Leukemia 2006;20(3):530-4.
2005: Laurentiu M Pop; Joan E Smallshaw; Thomas F Tucker; Freda K Stevenson; Ellen S Vitetta
Failure of vaccination with idiotypic protein or DNA, (+/-IL-2), the depletion of regulatory T cells, or the blockade of CTLA-4 to prolong dormancy in mice with BCL1 lymphoma.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2005;28(6):525-34.
2005: Freda K Stevenson
Update on cancer vaccines.
Current opinion in oncology 2005;17(6):573-7.
2005: Silvia Coenen; Becky M Pickering; Kathleen N Potter; Peter WM Johnson; Freda K Stevenson; Graham Packham
The relevance of sequence insertions in the Mcl-1 promoter in chronic lymphocytic leukemia and in normal cells.
Haematologica 2005;90(9):1285-6.
2005: Natalia Savelyeva; Catherine A King; Ellen S Vitetta; Freda K Stevenson
Inhibition of a vaccine-induced anti-tumor B cell response by soluble protein antigen in the absence of continuing T cell help.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(31):10987-92.
2005: Sarah Buchan; Eirik Grønevik; Iacob Mathiesen; Catherine A King; Freda K Stevenson; Jason Rice
Electroporation as a "prime/boost" strategy for naked DNA vaccination against a tumor antigen.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(10):6292-8.
2005: Graham Packham; Freda K Stevenson
Bodyguards and assassins: Bcl-2 family proteins and apoptosis control in chronic lymphocytic leukaemia.
Immunology 2005;114(4):441-9.
2005: Stuart D Perkins; M Gill Hartley; Roman A Lukaszewski; Robert J Phillpotts; Freda K Stevenson; Alice M Bennett
VP22 enhances antibody responses from DNA vaccines but not by intercellular spread.
Vaccine 2005;23(16):1931-40.
2005: Delin Zhu; Chen-Feng Qi; Herbert C Morse; Siegfried Janz; Freda K Stevenson
Deregulated expression of the Myc cellular oncogene drives development of mouse "Burkitt-like" lymphomas from naive B cells.
Blood 2005;105(5):2135-7.
2005: Freda K Stevenson
Turning genes into cancer vaccines.
Discovery medicine 2005;5(25):37-42.
2005: Katy J McCann; Surinder S Sahota; Freda K Stevenson; Christian H Ottensmeier
Idiotype gene rescue in follicular lymphoma.
Methods in molecular medicine 2005;115():145-71.
2005: Surinder S Sahota; Gavin Babbage; Niklas Zojer; Christian H Ottensmeier; Freda K Stevenson
Determining mutational status of immunoglobulin v genes in chronic lymphocytic leukemia: a useful prognostic indicator.
Methods in molecular medicine 2005;115():129-44.
2005: Surinder S Sahota; Mark Townsend; Freda K Stevenson
Identification and assembly of V genes as idiotype-specific DNA fusion vaccines in multiple myeloma.
Methods in molecular medicine 2005;113():105-19.
2004: Francesco Forconi; Surinder S Sahota; Donatella Raspadori; Micaela Ippoliti; Gavin Babbage; Francesco Lauria; Freda K Stevenson
Hairy cell leukemia: at the crossroad of somatic mutation and isotype switch.
Blood 2004;104(10):3312-7.
2004: Freda K Stevenson; Christian H Ottensmeier; Peter Johnson; Delin Zhu; Sarah L Buchan; Katy J McCann; Joanne S Roddick; Andrew T King; Feargal McNicholl; Natalia Savelyeva; Jason Rice
DNA vaccines to attack cancer.
Proceedings of the National Academy of Sciences of the United States of America 2004;101 Suppl 2():14646-52.
2004: Jason Rice; Sarah Buchan; Hamlata Dewchand; Elizabeth Simpson; Freda K Stevenson
DNA fusion vaccines induce targeted epitope-specific CTLs against minor histocompatibility antigens from a normal or tolerized repertoire.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(7):4492-9.
2004: Freda K Stevenson; Federico Caligaris-Cappio
Chronic lymphocytic leukemia: revelations from the B-cell receptor.
Blood 2004;103(12):4389-95.
2004: Freda K Stevenson; Jason Rice; Christian H Ottensmeier; Stephen M Thirdborough; Delin Zhu
DNA fusion gene vaccines against cancer: from the laboratory to the clinic.
Immunological reviews 2004;199():156-80.
2004: Freda K Stevenson
DNA vaccines and adjuvants.
Immunological reviews 2004;199():5-8.
2004: Gavin Babbage; Richard Garand; Nelly Robillard; Niklas Zojer; Freda K Stevenson; Surinder S Sahota
Mantle cell lymphoma with t(11;14) and unmutated or mutated VH genes expresses AID and undergoes isotype switch events.
Blood 2004;103(7):2795-8.
2004: Francesco Forconi; Daniela Capello; Eva Berra; Davide Rossi; Annunziata Gloghini; Michaela Cerri; Giuliana Muti; Enrica Morra; Marco Paulli; Umberto Magrini; Marco Lucioni; Alessandro Rambaldi; Francesco Lauria; Antonino Carbone; Freda K Stevenson; Gianluca Gaidano
Incidence of novel N-glycosylation sites in the B-cell receptor of lymphomas associated with immunodeficiency.
British journal of haematology 2004;124(5):604-9.
2004: C Ian Mockridge; Anisur Rahman; Sarah Buchan; Terry J Hamblin; David A Isenberg; Freda K Stevenson; Kathleen N Potter
Common patterns of B cell perturbation and expanded V4-34 immunoglobulin gene usage in autoimmunity and infection.
Autoimmunity 2004;37(1):9-15.
2004: Freda K Stevenson; Jason Rice; Delin Zhu
Tumor vaccines.
Advances in immunology 2004;82():49-103.
2003: Helen McCarthy; Christian H Ottensmeier; Terry J Hamblin; Freda K Stevenson
Anti-idiotype vaccines.
British journal of haematology 2003;123(5):770-81.
2003: Duncan A E Cochran; Caroline A Evans; David Blinco; John Burthem; Freda K Stevenson; Simon J Gaskell; Anthony D Whetton
Proteomic analysis of chronic lymphocytic leukemia subtypes with mutated or unmutated Ig V(H) genes.
Molecular & cellular proteomics : MCP 2003;2(12):1331-41.
2003: Fabrice Jardin; Christian Bastard; Nathalie Contentin; Françoise Parmentier; Jean-Michel Picquenot; Hervé Tilly; Freda K Stevenson; Surinder S Sahota
Intronic BCL-6 mutations are preferentially targeted to the translocated allele in t(3;14)(q27;q32) non-Hodgkin B-cell lymphoma.
Blood 2003;102(5):1872-6.
2003: Niklas Zojer; Heinz Ludwig; Michael Fiegl; Freda K Stevenson; Surinder S Sahota
Patterns of somatic mutations in VH genes reveal pathways of clonal transformation from MGUS to multiple myeloma.
Blood 2003;101(10):4137-9.
2003: Kathleen N Potter; Jennifer Orchard; Eustacia Critchley; C Ian Mockridge; Annette Jose; Freda K Stevenson
Features of the overexpressed V1-69 genes in the unmutated subset of chronic lymphocytic leukemia are distinct from those in the healthy elderly repertoire.
Blood 2003;101(8):3082-4.
2003: Surinder S Sahota; Francesco Forconi; Christian H Ottensmeier; Freda K Stevenson
Origins of the malignant clone in typical Waldenstrom's macroglobulinemia.
Seminars in oncology 2003;30(2):136-41.
2003: Freda K Stevenson; Andrew King; Christian H Ottensmeier
Vaccine therapy in NHL: future promises and current limitations.
Leukemia & lymphoma 2003;44 Suppl 3():S85-90.
2003: Natalia Savelyeva; Delin Zhu; Freda K Stevenson
Engineering DNA vaccines that include plant virus coat proteins.
Biotechnology & genetic engineering reviews 2003;20():101-14.
2003: Helen E Heslop; Freda K Stevenson; Jeffrey J Molldrem
Immunotherapy of hematologic malignancy.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2003;():331-49.
2003: Delin Zhu; Christian H Ottensmeier; Ming-Qing Du; Helen McCarthy; Freda K Stevenson
Incidence of potential glycosylation sites in immunoglobulin variable regions distinguishes between subsets of Burkitt's lymphoma and mucosa-associated lymphoid tissue lymphoma.
British journal of haematology 2003;120(2):217-22.
2002: Jason Rice; Brigitte D de Lima; Freda K Stevenson; Philip G Stevenson
A gamma-herpesvirus immune evasion gene allows tumor cells in vivo to escape attack by cytotoxic T cells specific for a tumor epitope.
European journal of immunology 2002;32(12):3481-7.
2002: Jason Rice; Sarah Buchan; Freda K Stevenson
Critical components of a DNA fusion vaccine able to induce protective cytotoxic T cells against a single epitope of a tumor antigen.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(7):3908-13.
2002: Kathleen N Potter; Paul Hobby; Susanne Klijn; Freda K Stevenson; Brian J Sutton
Evidence for involvement of a hydrophobic patch in framework region 1 of human V4-34-encoded Igs in recognition of the red blood cell I antigen.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(7):3777-82.
2002: Delin Zhu; Jennifer Orchard; David Oscier; Dennis H Wright; Freda K Stevenson
V(H) gene analysis of splenic marginal zone lymphomas reveals diversity in mutational status and initiation of somatic mutation in vivo.
Blood 2002;100(7):2659-61.
2002: Francesco Forconi; Catherine A King; Surinder S Sahota; Chris Kennaway; Nigel H Russell; Freda K Stevenson
Insight into the potential for DNA idiotypic fusion vaccines designed for patients by analysing xenogeneic anti-idiotypic antibody responses.
Immunology 2002;107(1):39-45.
2002: Surinder S Sahota; Francesco Forconi; Christian H Ottensmeier; Drew Provan; David Oscier; Terry J Hamblin; Freda K Stevenson
Typical Waldenstrom macroglobulinemia is derived from a B-cell arrested after cessation of somatic mutation but prior to isotype switch events.
Blood 2002;100(4):1505-7.
2002: Delin Zhu; Helen McCarthy; Christian H Ottensmeier; Peter Johnson; Terry J Hamblin; Freda K Stevenson
Acquisition of potential N-glycosylation sites in the immunoglobulin variable region by somatic mutation is a distinctive feature of follicular lymphoma.
Blood 2002;99(7):2562-8.
2002: Stephen M Thirdborough; Joanna N Radcliffe; Peter S Friedmann; Freda K Stevenson
Vaccination with DNA encoding a single-chain TCR fusion protein induces anticlonotypic immunity and protects against T-cell lymphoma.
Cancer research 2002;62(6):1757-60.
2002: Delin Zhu; Freda K Stevenson
DNA gene fusion vaccines against cancer.
Current opinion in molecular therapeutics 2002;4(1):41-8.
2002: Terry J Hamblin; Jenny A Orchard; Rachel E Ibbotson; Zadie Davis; Peter W Thomas; Freda K Stevenson; David Oscier
CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease.
Blood 2002;99(3):1023-9.
2002: Kathleen N Potter; C Ian Mockridge; Anisur Rahman; Sarah Buchan; Terry J Hamblin; B Davidson; D A Isenberg; Freda K Stevenson
Disturbances in peripheral blood B cell subpopulations in autoimmune patients.
Lupus 2002;11(12):872-7.
2001: Delin Zhu; Jason Rice; Natalia Savelyeva; Freda K Stevenson
DNA fusion vaccines against B-cell tumors.
Trends in molecular medicine 2001;7(12):566-72.
2001: Francesco Forconi; Surinder S Sahota; Donatella Raspadori; C Ian Mockridge; F Lauria; Freda K Stevenson
Tumor cells of hairy cell leukemia express multiple clonally related immunoglobulin isotypes via RNA splicing.
Blood 2001;98(4):1174-81.
2001: Natalia Savelyeva; R Munday; MB Spellerberg; G P Lomonossoff; Freda K Stevenson
Plant viral genes in DNA idiotypic vaccines activate linked CD4+ T-cell mediated immunity against B-cell malignancies.
Nature biotechnology 2001;19(8):760-4.
2001: K N Potter; RK Thomson; A Hamblin; SD Richards; J Gordon Lindsay; Freda K Stevenson
Immunogenetic analysis reveals that epitope shifting occurs during B-cell affinity maturation in primary biliary cirrhosis.
Journal of molecular biology 2001;306(1):37-46.
2001: Freda K Stevenson; Delin Zhu; Jason Rice
New strategies for vaccination and imunomodulation in NHL.
Annals of hematology 2001;80 Suppl 3():B132-4.
2001: Freda K Stevenson; Surinder S Sahota; Christian H Ottensmeier; Delin Zhu; Francesco Forconi; Terry J Hamblin
The occurrence and significance of V gene mutations in B cell-derived human malignancy.
Advances in cancer research 2001;83():81-116.
2001: Freda K Stevenson; W Rosenberg
DNA vaccination: a potential weapon against infection and cancer.
Vox sanguinis 2001;80(1):12-8.
2000: Christian H Ottensmeier; Freda K Stevenson
Isotype switch variants reveal clonally related subpopulations in diffuse large B-cell lymphoma.
Blood 2000;96(7):2550-6.
2000: Surinder S Sahota; Zadie Davis; Terry J Hamblin; Freda K Stevenson
Somatic mutation of bcl-6 genes can occur in the absence of V(H) mutations in chronic lymphocytic leukemia.
Blood 2000;95(11):3534-40.
2000: Freda K Stevenson; Kenneth C Anderson
Preparing the ground for vaccination against multiple myeloma.
Immunology today 2000;21(4):170-1.
2000: Terry J Hamblin; Jenny A Orchard; Anne Gardiner; David Oscier; Zadie Davis; Freda K Stevenson
Immunoglobulin V genes and CD38 expression in CLL.
Blood 2000;95(7):2455-7.
2000: HE Baxendale; Z Davis; H N White; MB Spellerberg; Freda K Stevenson; David Goldblatt
Immunogenetic analysis of the immune response to pneumococcal polysaccharide.
European journal of immunology 2000;30(4):1214-23.
2000: Neelima bhat; Marcia M Bieber; MB Spellerberg; Freda K Stevenson; Nelson N Teng
Recognition of auto- and exoantigens by V4-34 gene encoded antibodies.
Scandinavian journal of immunology 2000;51(2):134-40.
2000: D Zhu; M B Spellerberg; C A King; J Rice; A R Thompsett; Freda K Stevenson
DNA fusion vaccines against B-cell tumors.
Methods in molecular medicine 2000;29():405-23.
2000: Freda K Stevenson; Delin Zhu; MB Spellerberg; Jason Rice; Catherine A King; AR Thompsett; Surinder S Sahota; Terry J Hamblin
DNA vaccination against cancer antigens.
Ernst Schering Research Foundation workshop 2000;(30):119-36.
1999: Freda K Stevenson
DNA vaccines against cancer: from genes to therapy.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1999;10(12):1413-8.
1999: RE Snow; R Djukanovic; Freda K Stevenson
Analysis of immunoglobulin E VH transcripts in a bronchial biopsy of an asthmatic patient confirms bias towards VH5, and indicates local clonal expansion, somatic mutation and isotype switch events.
Immunology 1999;98(4):646-51.
1999: D Zhu; A R Thompsett; George Bedu-Addo; Freda K Stevenson; Imelda Bates
VH gene sequences from a novel tropical splenic lymphoma reveal a naive B cell as the cell of origin.
British journal of haematology 1999;107(1):114-20.
1999: Terry J Hamblin; Zadie Davis; Anne Gardiner; David Oscier; Freda K Stevenson
Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia.
Blood 1999;94(6):1848-54.
1999: A R Thompsett; D W Ellison; Freda K Stevenson; D Zhu
V(H) gene sequences from primary central nervous system lymphomas indicate derivation from highly mutated germinal center B cells with ongoing mutational activity.
Blood 1999;94(5):1738-46.
1999: Jason Rice; Catherine A King; MB Spellerberg; N Fairweather; Freda K Stevenson
Manipulation of pathogen-derived genes to influence antigen presentation via DNA vaccines.
Vaccine 1999;17(23-24):3030-8.
1999: Surinder S Sahota; Richard Garand; R Mahroof; A Smith; Nadine Juge-Morineau; Freda K Stevenson; Régis Bataille
V(H) gene analysis of IgM-secreting myeloma indicates an origin from a memory cell undergoing isotype switch events.
Blood 1999;94(3):1070-6.
1999: Freda K Stevenson; J Natvig
Autoantibodies revealed: the role of B cells in autoimmune disease.
Immunology today 1999;20(7):296-8.
1999: Freda K Stevenson; Catherine A King; MB Spellerberg; Delin Zhu; Jason Rice; Surinder S Sahota; AR Thompsett; J Radl; Terry J Hamblin
DNA vaccines against haematological malignancies.
Haematologica 1999;84 Suppl EHA-4():11-3.
1999: Freda K Stevenson; Surinder S Sahota
B cell maturation in relation to multiple myeloma.
Pathologie-biologie 1999;47(2):89-97.
1999: M D Thomas; K Clough; M D Melamed; Freda K Stevenson; CJ Chapman; MB Spellerberg; K N Potter; J A Newton-Bishop; N Gregson; K Dawson
A human monoclonal antibody encoded by the V4-34 gene segment recognises melanoma-associated ganglioside via CDR3 and FWR1.
Human antibodies 1999;9(2):95-106.
1998: CJ Chapman; D Wright; H P Feizi; Z Davis; Freda K Stevenson
V(H) gene analysis of Burkitt's lymphoma in children from north-western Iran.
British journal of haematology 1998;103(4):1116-23.
1998: Catherine A King; MB Spellerberg; Delin Zhu; Jason Rice; Surinder S Sahota; AR Thompsett; Terry J Hamblin; J Radl; Freda K Stevenson
DNA vaccines with single-chain Fv fused to fragment C of tetanus toxin induce protective immunity against lymphoma and myeloma.
Nature medicine 1998;4(11):1281-6.
1998: RE Snow; CJ Chapman; S T Holgate; Freda K Stevenson
Clonally related IgE and IgG4 transcripts in blood lymphocytes of patients with asthma reveal differing patterns of somatic mutation.
European journal of immunology 1998;28(10):3354-61.
1998: C Ian Mockridge; CJ Chapman; MB Spellerberg; Bhavwanti Sheth; T P Fleming; D A Isenberg; Freda K Stevenson
Sequence analysis of V(4-34)-encoded antibodies from single B cells of two patients with systemic lupus erythematosus (SLE).
Clinical and experimental immunology 1998;114(1):129-36.
1998: CJ Chapman; D Wright; Freda K Stevenson
Insight into Burkitt's lymphoma from immunoglobulin variable region gene analysis.
Leukemia & lymphoma 1998;30(3-4):257-67.
1998: Christian H Ottensmeier; AR Thompsett; Delin Zhu; BS Wilkins; John W Sweetenham; Freda K Stevenson
Analysis of VH genes in follicular and diffuse lymphoma shows ongoing somatic mutation and multiple isotype transcripts in early disease with changes during disease progression.
Blood 1998;91(11):4292-9.
1998: RK Thomson; Z Davis; Jeremy M Palmer; M J Arthur; Stephen J Yeaman; CJ Chapman; MB Spellerberg; Freda K Stevenson
Immunogenetic analysis of a panel of monoclonal IgG and IgM anti-PDC-E2/X antibodies derived from patients with primary biliary cirrhosis.
Journal of hepatology 1998;28(4):582-94.
1998: A Janezic; CJ Chapman; RE Snow; J O Hourihane; J O Warner; Freda K Stevenson
Immunogenetic analysis of the heavy chain variable regions of IgE from patients allergic to peanuts.
The Journal of allergy and clinical immunology 1998;101(3):391-6.
1998: Delin Zhu; C van Arkel; Catherine A King; S V Meirvenne; Catherine De Greef; Kris Thielemans; J Radl; Freda K Stevenson
Immunoglobulin VH gene sequence analysis of spontaneous murine immunoglobulin-secreting B-cell tumours with clinical features of human disease.
Immunology 1998;93(2):162-70.
1998: Surinder S Sahota; Richard Garand; Régis Bataille; A J Smith; Freda K Stevenson
VH gene analysis of clonally related IgM and IgG from human lymphoplasmacytoid B-cell tumors with chronic lymphocytic leukemia features and high serum monoclonal IgG.
Blood 1998;91(1):238-43.
1997: MB Spellerberg; Delin Zhu; AR Thompsett; Catherine A King; Terry J Hamblin; Freda K Stevenson
DNA vaccines against lymphoma: promotion of anti-idiotypic antibody responses induced by single chain Fv genes by fusion to tetanus toxin fragment C.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(4):1885-92.
1997: David Oscier; A Thompsett; D Zhu; Freda K Stevenson
Differential rates of somatic hypermutation in V(H) genes among subsets of chronic lymphocytic leukemia defined by chromosomal abnormalities.
Blood 1997;89(11):4153-60.
1997: Delin Zhu; MB Spellerberg; AR Thompsett; Catherine A King; Terry J Hamblin; Freda K Stevenson
DNA vaccination as cancer immunotherapy.
Biochemical Society transactions 1997;25(2):743-7.
1997: Neelima bhat; Marcia M Bieber; Frank J Hsu; C J Chapman; MB Spellerberg; Freda K Stevenson; Nelson N Teng
Rapid cytotoxicity of human B lymphocytes induced by VH4-34 (VH4.21) gene-encoded monoclonal antibodies, II.
Clinical and experimental immunology 1997;108(1):151-9.
1997: CJ Chapman; C Ian Mockridge; MB Spellerberg; Delin Zhu; Freda K Stevenson
Phage surface expression for analysis of recognition sites of human autoantibodies: comparison of single chain Fv and Fab.
Human antibodies 1997;8(3):124-8.
1997: Freda K Stevenson; G J Silverman
Expression of anti-DNA antibodies.
Lupus 1997;6(3):321-3.
1997: RE Snow; CJ Chapman; A J Frew; S T Holgate; Freda K Stevenson
Pattern of usage and somatic hypermutation in the V(H)5 gene segments of a patient with asthma: implications for IgE.
European journal of immunology 1997;27(1):162-70.
1997: Surinder S Sahota; R Leo; Terry J Hamblin; Freda K Stevenson
Myeloma VL and VH gene sequences reveal a complementary imprint of antigen selection in tumor cells.
Blood 1997;89(1):219-26.