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William Steward

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Glen R B Irving; Donald J L Jones; Ines Kralj-Hans; Andrew S Miller; Stewart Sale; Edwina N Scott; Wendy S Atkin; David P Berry; Robert G Britton; Karen Brown; Susan K Clark; Andreas J Gescher; David Hemingway; Lynne M Howells; William P Steward
Prolonged biologically active colonic tissue levels of curcumin achieved after oral administration--a clinical pilot study including assessment of patient acceptability.
Shaban E A Saad; William P Steward; Robert G Britton; Karen Brown; Andreas J Gescher; Emma Horner-Glister; Donald J L Jones; Leonie M Norris; Ketan R Patel; Stewart Sale
Tissue distribution and metabolism of the putative cancer chemopreventive agent 3',4',5'-trimethoxyflavonol (TMFol) in mice.
Robert G Britton; Karen Brown; Roanne Denton; Andreas Gescher; Emma Horner-Glister; Paul R Jenkins; Odette A Pomenya; Ewan E Smith; William P Steward; Stewart Sale
Synthesis and biological evaluation of novel flavonols as potential anti-prostate cancer agents.

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2013: Glen R B Irving; Donald J L Jones; Ines Kralj-Hans; Andrew S Miller; Stewart Sale; Edwina N Scott; Wendy S Atkin; David P Berry; Robert G Britton; Karen Brown; Susan K Clark; Andreas J Gescher; David Hemingway; Lynne M Howells; William P Steward
Prolonged biologically active colonic tissue levels of curcumin achieved after oral administration--a clinical pilot study including assessment of patient acceptability.
Cancer prevention research (Philadelphia, Pa.) 2013;6(2):119-28.
2012: Shaban E A Saad; William P Steward; Robert G Britton; Karen Brown; Andreas J Gescher; Emma Horner-Glister; Donald J L Jones; Leonie M Norris; Ketan R Patel; Stewart Sale
Tissue distribution and metabolism of the putative cancer chemopreventive agent 3',4',5'-trimethoxyflavonol (TMFol) in mice.
Biomedical chromatography : BMC 2012;26(12):1559-66.
2012: Robert G Britton; Karen Brown; Roanne Denton; Andreas Gescher; Emma Horner-Glister; Paul R Jenkins; Odette A Pomenya; Ewan E Smith; William P Steward; Stewart Sale
Synthesis and biological evaluation of novel flavonols as potential anti-prostate cancer agents.
European journal of medicinal chemistry 2012;54():952-8.
2012: Ankur Karmokar; Timothy H Marczylo; William P Steward; Hong Cai; Andreas J Gescher; Karen Brown
Dietary intake of rosmarinic acid by Apc(Min) mice, a model of colorectal carcinogenesis: levels of parent agent in the target tissue and effect on adenoma development.
Molecular nutrition & food research 2012;56(5):775-83.
2011: Lynne M Howells; E W Jacobson; William P Steward; B Hegarty; E Hoffmann; David P Berry; Karen Brown; P J Elliott; Andreas J Gescher
Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases--safety, pharmacokinetics, and pharmacodynamics.
Cancer prevention research (Philadelphia, Pa.) 2011;4(9):1419-25.
2011: Friederike Teichert; Swantje Winkler; William P Steward; Peter B Farmer; Andreas J Gescher; Hector C Keun; Rajinder Singh
Evaluation of urinary ribonucleoside profiling for clinical biomarker discovery using constant neutral loss scanning liquid chromatography/tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM 2011;25(14):2071-82.
2011: Lynne M Howells; Glen R B Irving; Donald J L Jones; Christopher D Mann; Margaret M Manson; Christopher J Ottley; D Graham Pearson; Stewart Sale; Sathya Neelature Sriramareddy; William P Steward; David P Berry; Andreas Gescher; Karen Brown
Curcumin ameliorates oxaliplatin-induced chemoresistance in HCT116 colorectal cancer cells in vitro and in vivo.
International journal of cancer. Journal international du cancer 2011;129(2):476-86.
2011: Hong Cai; Sarah C Thomasset; Giuseppe Garcea; Karen Brown; William P Steward; David P Berry; Andreas J Gescher
Determination of anthocyanins in the urine of patients with colorectal liver metastases after administration of bilberry extract.
Biomedical chromatography : BMC 2011;25(6):660-3.
2011: Hong Cai; Stewart Sale; Robert G Britton; Karen Brown; William P Steward; Andreas J Gescher
Pharmacokinetics in mice and metabolism in murine and human liver fractions of the putative cancer chemopreventive agents 3',4',5',5,7-pentamethoxyflavone and tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone).
Cancer chemotherapy and pharmacology 2011;67(2):255-63.
2011: Ketan R Patel; Edwina Scott; Victoria A Brown; Andreas J Gescher; William P Steward; Karen Brown
Clinical trials of resveratrol.
Annals of the New York Academy of Sciences 2011;1215():161-9.
2010: Victoria A Brown; Ketan R Patel; Maria Viskaduraki; James A Crowell; Marjorie Perloff; Tristan D Booth; Grygoriy Vasilinin; Ananda Sen; Anna Maria Schinas; Gianfranca Piccirilli; Karen Brown; William P Steward; Andreas J Gescher; Dean E Brenner
Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis.
Cancer research 2010;70(22):9003-11.
2010: Friederike Teichert; Richard D Verschoyle; Peter Greaves; Donald J L Jones; Ian D Wilson; Peter B Farmer; William P Steward; Andreas J Gescher; Hector C Keun
Plasma metabolic profiling reveals age-dependency of systemic effects of green tea polyphenols in mice with and without prostate cancer.
Molecular bioSystems 2010;6(10):1911-6.
2010: Rajinder Singh; Friederike Teichert; Albrecht Seidel; Jonathan Roach; Rebecca Cordell; Mai-Kim Cheng; Heinrich Frank; William P Steward; Margaret M Manson; Peter B Farmer
Development of a targeted adductomic method for the determination of polycyclic aromatic hydrocarbon DNA adducts using online column-switching liquid chromatography/tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM 2010;24(16):2329-40.
2010: Lynne M Howells; Robert G Britton; Marco Mazzoletti; Peter Greaves; Massimo Broggini; Karen Brown; William P Steward; Andreas J Gescher; Stewart Sale
Preclinical colorectal cancer chemopreventive efficacy and p53-modulating activity of 3',4',5'-trimethoxyflavonol, a quercetin analogue.
Cancer prevention research (Philadelphia, Pa.) 2010;3(8):929-39.
2010: Hong Cai; Timothy H Marczylo; Nicole Teller; Karen Brown; William P Steward; Doris Marko; Andreas J Gescher
Anthocyanin-rich red grape extract impedes adenoma development in the Apc(Min) mouse: pharmacodynamic changes and anthocyanin levels in the murine biophase.
European journal of cancer (Oxford, England : 1990) 2010;46(4):811-7.
2009: Stewart Sale; Isabel L Fong; Carla de Giovanni; Lorena Landuzzi; Karen Brown; William P Steward; Andreas J Gescher
APC10.1 cells as a model for assessing the efficacy of potential chemopreventive agents in the Apc(Min) mouse model in vivo.
European journal of cancer (Oxford, England : 1990) 2009;45(16):2731-5.
2009: Timothy H Marczylo; Darren Cooke; Karen Brown; William P Steward; Andreas J Gescher
Pharmacokinetics and metabolism of the putative cancer chemopreventive agent cyanidin-3-glucoside in mice.
Cancer chemotherapy and pharmacology 2009;64(6):1261-8.
2009: Hong Cai; Stewart Sale; Ralf Schmid; Robert G Britton; Karen Brown; William P Steward; Andreas J Gescher
Flavones as colorectal cancer chemopreventive agents--phenol-o-methylation enhances efficacy.
Cancer prevention research (Philadelphia, Pa.) 2009;2(8):743-50.
2009: Sarah Thomasset; David P Berry; Hong Cai; Kevin West; Timothy H Marczylo; Debbie Marsden; Karen Brown; Ashley Dennison; Giuseppe Garcea; Andrew Miller; David Hemingway; William P Steward; Andreas J Gescher
Pilot study of oral anthocyanins for colorectal cancer chemoprevention.
Cancer prevention research (Philadelphia, Pa.) 2009;2(7):625-33.
2009: Jatinderpal Sandhu; Balvinder Kaur; Christine Armstrong; Christopher J Talbot; William P Steward; Peter B Farmer; Rajinder Singh
Determination of 5-methyl-2'-deoxycytidine in genomic DNA using high performance liquid chromatography-ultraviolet detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(20-21):1957-61.
2009: Edwina N Scott; Andreas J Gescher; William P Steward; Karen Brown
Development of dietary phytochemical chemopreventive agents: biomarkers and choice of dose for early clinical trials.
Cancer prevention research (Philadelphia, Pa.) 2009;2(6):525-30.
2009: Rajinder Singh; Jatinderpal Sandhu; Balvinder Kaur; Tina Juren; William P Steward; Dan Segerbäck; Peter B Farmer
Evaluation of the DNA damaging potential of cannabis cigarette smoke by the determination of acetaldehyde derived N2-ethyl-2'-deoxyguanosine adducts.
Chemical research in toxicology 2009;22(6):1181-8.
2009: Sarah Thomasset; Nicole Teller; Hong Cai; Doris Marko; David P Berry; William P Steward; Andreas J Gescher
Do anthocyanins and anthocyanidins, cancer chemopreventive pigments in the diet, merit development as potential drugs?
Cancer chemotherapy and pharmacology 2009;64(1):201-11.
2009: Robert G Britton; Isabel Fong; Shaban Saad; Karen Brown; William P Steward; Andreas Gescher; Stewart Sale
Synthesis of the flavonoid 3',4',5'-trimethoxyflavonol and its determination in plasma and tissues of mice by HPLC with fluorescence detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(10):939-42.
2009: Hong Cai; Karen Brown; William P Steward; Andreas J Gescher
Determination of 3',4',5',5,7-pentamethoxyflavone in the plasma and intestinal mucosa of mice by HPLC with UV detection.
Biomedical chromatography : BMC 2009;23(4):335-9.
2009: Timothy H Marczylo; William P Steward; Andreas J Gescher
Rapid analysis of curcumin and curcumin metabolites in rat biomatrices using a novel ultraperformance liquid chromatography (UPLC) method.
Journal of agricultural and food chemistry 2009;57(3):797-803.
2009: S L Ong; Giuseppe Garcea; C A Pollard; Peter N Furness; William P Steward; Arumugam Rajesh; L Spencer; D M Lloyd; David P Berry; Ashley R Dennison
A fuller understanding of pancreatic neuroendocrine tumours combined with aggressive management improves outcome.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2009;9(5):583-600.
2009: Christopher P Neal; Christopher D Mann; Christopher D Sutton; Giuseppe Garcea; S L Ong; William P Steward; Ashley R Dennison; David P Berry
Evaluation of the prognostic value of systemic inflammation and socioeconomic deprivation in patients with resectable colorectal liver metastases.
European journal of cancer (Oxford, England : 1990) 2009;45(1):56-64.
2008: William P Steward; Andreas J Gescher
Curcumin in cancer management: recent results of analogue design and clinical studies and desirable future research.
Molecular nutrition & food research 2008;52(9):1005-9.
2008: Friederike Teichert; Richard D Verschoyle; Peter Greaves; Richard E Edwards; Orla Teahan; Donald J L Jones; Ian D Wilson; Peter B Farmer; William P Steward; Timothy W Gant; Andreas J Gescher; Hector C Keun
Metabolic profiling of transgenic adenocarcinoma of mouse prostate (TRAMP) tissue by 1H-NMR analysis: evidence for unusual phospholipid metabolism.
The Prostate 2008;68(10):1035-47.
2008: Richard D Verschoyle; Karen Brown; William P Steward; Andreas J Gescher
Consumption of silibinin, a flavonolignan from milk thistle, and mammary cancer development in the C3(1) SV40 T,t antigen transgenic multiple mammary adenocarcinoma (TAg) mouse.
Cancer chemotherapy and pharmacology 2008;62(2):369-72.
2008: Gabriela M Almeida; Tiago L Duarte; Peter B Farmer; William P Steward; George D D Jones
Multiple end-point analysis reveals cisplatin damage tolerance to be a chemoresistance mechanism in a NSCLC model: implications for predictive testing.
International journal of cancer. Journal international du cancer 2008;122(8):1810-9.
2008: Richard D Verschoyle; Peter Greaves; Ketan Patel; Debbie A Marsden; Karen Brown; William P Steward; Andreas J Gescher
Evaluation of the cancer chemopreventive efficacy of silibinin in genetic mouse models of prostate and intestinal carcinogenesis: relationship with silibinin levels.
European journal of cancer (Oxford, England : 1990) 2008;44(6):898-906.
2008: Sanjeev Pathak; Rajinder Singh; Richard D Verschoyle; Peter Greaves; Peter B Farmer; William P Steward; J Kilian Mellon; Andreas J Gescher; Ricky A Sharma
Androgen manipulation alters oxidative DNA adduct levels in androgen-sensitive prostate cancer cells grown in vitro and in vivo.
Cancer letters 2008;261(1):74-83.
2007: Hong Cai; David J Boocock; William P Steward; Andreas J Gescher
Tissue distribution in mice and metabolism in murine and human liver of apigenin and tricin, flavones with putative cancer chemopreventive properties.
Cancer chemotherapy and pharmacology 2007;60(2):257-66.
2007: Timothy H Marczylo; Richard D Verschoyle; Darren N Cooke; Paolo Morazzoni; William P Steward; Andreas J Gescher
Comparison of systemic availability of curcumin with that of curcumin formulated with phosphatidylcholine.
Cancer chemotherapy and pharmacology 2007;60(2):171-7.
2007: David J Boocock; Guy E S Faust; Ketan R Patel; Anna M Schinas; Victoria A Brown; Murray P Ducharme; Tristan D Booth; James A Crowell; Marjorie Perloff; Andreas J Gescher; William P Steward; Dean E Brenner
Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007;16(6):1246-52.
2007: William P Steward; Mark R Middleton; A Benghiat; Paul M Loadman; C Hayward; S Waller; S Ford; Gavin Halbert; Laurence H Patterson; D Talbot
The use of pharmacokinetic and pharmacodynamic end points to determine the dose of AQ4N, a novel hypoxic cell cytotoxin, given with fractionated radiotherapy in a phase I study.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2007;18(6):1098-103.
2007: Siminder Kaur; Peter Greaves; Darren N Cooke; Richard Edwards; William P Steward; Andreas J Gescher; Timothy H Marczylo
Breast cancer prevention by green tea catechins and black tea theaflavins in the C3(1) SV40 T,t antigen transgenic mouse model is accompanied by increased apoptosis and a decrease in oxidative DNA adducts.
Journal of agricultural and food chemistry 2007;55(9):3378-85.
2007: Carmen S L Hoh; David J Boocock; Timothy H Marczylo; V A Brown; Hong Cai; William P Steward; David P Berry; Andreas J Gescher
Quantitation of silibinin, a putative cancer chemopreventive agent derived from milk thistle (Silybum marianum), in human plasma by high-performance liquid chromatography and identification of possible metabolites.
Journal of agricultural and food chemistry 2007;55(7):2532-5.
2007: J F Thorpe; S Jain; Timothy H Marczylo; Andreas J Gescher; William P Steward; J Kilian Mellon
A review of phase III clinical trials of prostate cancer chemoprevention.
Annals of the Royal College of Surgeons of England 2007;89(3):207-11.
2007: Anne L Thomas; Tanja Trarbach; C Bartel; Dirk Laurent; Andrew Henry; M Poethig; J Wang; E Masson; William P Steward; Udo Vanhoefer; Bertram Wiedenmann
A phase IB, open-label dose-escalating study of the oral angiogenesis inhibitor PTK787/ZK 222584 (PTK/ZK), in combination with FOLFOX4 chemotherapy in patients with advanced colorectal cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2007;18(4):782-8.
2007: David J Boocock; Ketan R Patel; Guy E S Faust; Daniel Normolle; Timothy H Marczylo; James A Crowell; Dean E Brenner; Tristan D Booth; Andreas J Gescher; William P Steward
Quantitation of trans-resveratrol and detection of its metabolites in human plasma and urine by high performance liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;848(2):182-7.
2007: Sarah C Thomasset; David P Berry; Giuseppe Garcea; Timothy H Marczylo; William P Steward; Andreas J Gescher
Dietary polyphenolic phytochemicals--promising cancer chemopreventive agents in humans? A review of their clinical properties.
International journal of cancer. Journal international du cancer 2007;120(3):451-8.
2007: Richard D Verschoyle; Peter Greaves; Hong Cai; Richard E Edwards; William P Steward; Andreas J Gescher
Evaluation of the cancer chemopreventive efficacy of rice bran in genetic mouse models of breast, prostate and intestinal carcinogenesis.
British journal of cancer 2007;96(2):248-54.
2007: Richard D Verschoyle; William P Steward; Andreas J Gescher
Putative cancer chemopreventive agents of dietary origin-how safe are they?
Nutrition and cancer 2007;59(2):152-62.
2006: Mohammad Al-Fayez; Hong Cai; Richard G Tunstall; William P Steward; Andreas J Gescher
Differential modulation of cyclooxygenase-mediated prostaglandin production by the putative cancer chemopreventive flavonoids tricin, apigenin and quercetin.
Cancer chemotherapy and pharmacology 2006;58(6):816-25.
2006: Darren Cooke; Michael Schwarz; David J Boocock; Peter Winterhalter; William P Steward; Andreas J Gescher; Timothy H Marczylo
Effect of cyanidin-3-glucoside and an anthocyanin mixture from bilberry on adenoma development in the ApcMin mouse model of intestinal carcinogenesis--relationship with tissue anthocyanin levels.
International journal of cancer. Journal international du cancer 2006;119(9):2213-20.
2006: Stewart Sale; Richard G Tunstall; Ketan Chatrabhuj Ruparelia; PC Butler; Gerry A Potter; William P Steward; Andreas J Gescher
Effects of the potential chemopreventive agent DMU-135 on adenoma development in the ApcMin+ mouse.
Investigational new drugs 2006;24(6):459-64.
2006: Hong Cai; Delphine Raynaud; William P Steward; Andreas J Gescher
A simple HPLC method for the determination of apigenin in mouse tissues.
Biomedical chromatography : BMC 2006;20(10):1038-42.
2006: Darren N Cooke; Sarah C Thomasset; David J Boocock; Michael Schwarz; Peter Winterhalter; William P Steward; Andreas J Gescher; Timothy H Marczylo
Development of analyses by high-performance liquid chromatography and liquid chromatography/tandem mass spectrometry of bilberry (Vaccinium myrtilus) anthocyanins in human plasma and urine.
Journal of agricultural and food chemistry 2006;54(19):7009-13.
2006: Giuseppe Garcea; Helena Doucas; William P Steward; Ashley R Dennison; David P Berry
Hypoxia and angiogenesis in pancreatic cancer.
ANZ journal of surgery 2006;76(9):830-42.
2006: Alastair Greystoke; Sarah Blagden; Anne L Thomas; E Scott; Gerhardt Attard; R Molife; Laura Vidal; Simon Pacey; D Sarkar; A Jenner; Johann S de Bono; William P Steward
A phase I study of intravenous TZT-1027 administered on day 1 and day 8 of a three-weekly cycle in combination with carboplatin given on day 1 alone in patients with advanced solid tumours.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2006;17(8):1313-9.
2006: Lucy Lee; Sunil Sharma; Bruno Morgan; Peter R Allegrini; Christian R Schnell; Josef Brueggen; Robert Cozens; Mark A Horsfield; Clemens Guenther; William P Steward; Joachim Drevs; David Lebwohl; Jeanette Wood; Paul M J McSheehy
Biomarkers for assessment of pharmacologic activity for a vascular endothelial growth factor (VEGF) receptor inhibitor, PTK787/ZK 222584 (PTK/ZK): translation of biological activity in a mouse melanoma metastasis model to phase I studies in patients with advanced colorectal cancer with liver metastases.
Cancer chemotherapy and pharmacology 2006;57(6):761-71.
2006: Bruno Morgan; J F Utting; A Higginson; Anne L Thomas; William P Steward; Mark A Horsfield
A simple, reproducible method for monitoring the treatment of tumours using dynamic contrast-enhanced MR imaging.
British journal of cancer 2006;94(10):1420-7.
2006: Carmen Hoh; David J Boocock; Timothy H Marczylo; Rajinder Singh; David P Berry; Ashley R Dennison; David Hemingway; Andrew Miller; Kevin West; Stephanie A Euden; Giuseppe Garcea; Peter B Farmer; William P Steward; Andreas J Gescher
Pilot study of oral silibinin, a putative chemopreventive agent, in colorectal cancer patients: silibinin levels in plasma, colorectum, and liver and their pharmacodynamic consequences.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(9):2944-50.
2006: Christopher P Neal; David P Berry; Helena Doucas; Margaret M Manson; William P Steward; Giuseppe Garcea
Clinical aspects of natural anti-angiogenic drugs.
Current drug targets 2006;7(3):371-83.
2006: Gabriela M Almeida; Tiago L Duarte; William P Steward; George D D Jones
Detection of oxaliplatin-induced DNA crosslinks in vitro and in cancer patients using the alkaline comet assay.
DNA repair 2006;5(2):219-25.
2006: Richard G Tunstall; Ricky A Sharma; Sarah Perkins; Stewart Sale; Raj Singh; Peter B Farmer; William P Steward; Andreas J Gescher
Cyclooxygenase-2 expression and oxidative DNA adducts in murine intestinal adenomas: modification by dietary curcumin and implications for clinical trials.
European journal of cancer (Oxford, England : 1990) 2006;42(3):415-21.
2006: Richard D Verschoyle; Peter Greaves; Hong Cai; Arndt Borkhardt; Massimo Broggini; Maurizio D'Incalci; Edward S Riccio; Rupa Doppalapudi; Izet M Kapetanovic; William P Steward; Andreas J Gescher
Preliminary safety evaluation of the putative cancer chemopreventive agent tricin, a naturally occurring flavone.
Cancer chemotherapy and pharmacology 2006;57(1):1-6.
2005: Giuseppe Garcea; Christopher P Neal; Clare J Pattenden; William P Steward; David P Berry
Molecular prognostic markers in pancreatic cancer: a systematic review.
European journal of cancer (Oxford, England : 1990) 2005;41(15):2213-36.
2005: Hong Cai; Mohammad Al-Fayez; Richard G Tunstall; Sharon L Platton; Peter Greaves; William P Steward; Andreas J Gescher
The rice bran constituent tricin potently inhibits cyclooxygenase enzymes and interferes with intestinal carcinogenesis in ApcMin mice.
Molecular cancer therapeutics 2005;4(9):1287-92.
2005: Darren Cooke; William P Steward; Andreas J Gescher; Timothy H Marczylo
Anthocyans from fruits and vegetables--does bright colour signal cancer chemopreventive activity?
European journal of cancer (Oxford, England : 1990) 2005;41(13):1931-40.
2005: Ricky A Sharma; Andreas J Gescher; William P Steward
Curcumin: the story so far.
European journal of cancer (Oxford, England : 1990) 2005;41(13):1955-68.
2005: Hong Cai; William P Steward; Andreas J Gescher
Determination of the putative cancer chemopreventive flavone tricin in plasma and tissues of mice by HPLC with UV--visible detection.
Biomedical chromatography : BMC 2005;19(7):518-22.
2005: Anne L Thomas; Bruno Morgan; Mark A Horsfield; Anthony Higginson; Andrea Kay; Lucy Lee; Eric Masson; Marie Puccio-Pick; Dirk Laurent; William P Steward
Phase I study of the safety, tolerability, pharmacokinetics, and pharmacodynamics of PTK787/ZK 222584 administered twice daily in patients with advanced cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(18):4162-71.
2005: Stewart Sale; Richard G Tunstall; Ketan Chatrabhuj Ruparelia; Gerry A Potter; William P Steward; Andreas J Gescher
Comparison of the effects of the chemopreventive agent resveratrol and its synthetic analog trans 3,4,5,4'-tetramethoxystilbene (DMU-212) on adenoma development in the Apc(Min+) mouse and cyclooxygenase-2 in human-derived colon cancer cells.
International journal of cancer. Journal international du cancer 2005;115(2):194-201.
2005: BT Sherwood; George D D Jones; J Kilian Mellon; Roger C Kockelbergh; William P Steward; R Paul Symonds
Concomitant chemoradiotherapy for muscle-invasive bladder cancer: the way forward for bladder preservation?
Clinical oncology (Royal College of Radiologists (Great Britain)) 2005;17(3):160-6.
2005: Joachim Drevs; Ute Zirrgiebel; Carmen Schmidt-Gersbach; Klaus Mross; Michael Medinger; Lucy Lee; J Pinheiro; Jeanette Wood; Anne L Thomas; Clemens Unger; Andrew Henry; William P Steward; Dirk Laurent; David Lebwohl; Margaret Dugan; Dieter Marmé
Soluble markers for the assessment of biological activity with PTK787/ZK 222584 (PTK/ZK), a vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor in patients with advanced colorectal cancer from two phase I trials.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2005;16(4):558-65.
2005: Giuseppe Garcea; David P Berry; Donald J L Jones; Raj Singh; Ashley R Dennison; Peter B Farmer; Ricky A Sharma; William P Steward; Andreas J Gescher
Consumption of the putative chemopreventive agent curcumin by cancer patients: assessment of curcumin levels in the colorectum and their pharmacodynamic consequences.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2005;14(1):120-5.
2005: Margaret M Manson; Peter B Farmer; Andreas J Gescher; William P Steward
Innovative agents in cancer prevention.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 2005;166():257-75.
2005: S K Pathak; Ricky A Sharma; William P Steward; J Kilian Mellon; T R L Griffiths; Andreas J Gescher
Oxidative stress and cyclooxygenase activity in prostate carcinogenesis: targets for chemopreventive strategies.
European journal of cancer (Oxford, England : 1990) 2005;41(1):61-70.
2004: S I Ahmed; Anne L Thomas; William P Steward
Vascular endothelial growth factor (VEGF) inhibition by small molecules.
Journal of chemotherapy (Florence, Italy) 2004;16 Suppl 4():59-63.
2004: Ricky A Sharma; Stephanie A Euden; Sharon L Platton; Darren N Cooke; Aisha Shafayat; Heather R Hewitt; Timothy H Marczylo; Bruno Morgan; David Hemingway; Simon M Plummer; Munir Pirmohamed; Andreas J Gescher; William P Steward
Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(20):6847-54.
2004: Sarah Donald; Richard D Verschoyle; Peter Greaves; Tina Colombo; Massimo Zucchetti; Cristiano Falcioni; Marco Zaffaroni; Maurizio D'Incalci; Margaret M Manson; José Jimeno; William P Steward; Andreas J Gescher
Dietary agent indole-3-carbinol protects female rats against the hepatotoxicity of the antitumor drug ET-743 (trabectidin) without compromising efficacy in a rat mammary carcinoma.
International journal of cancer. Journal international du cancer 2004;111(6):961-7.
2004: Hong Cai; E Ann Hudson; P Mann; Richard D Verschoyle; Peter Greaves; Margaret M Manson; William P Steward; Andreas J Gescher
Growth-inhibitory and cell cycle-arresting properties of the rice bran constituent tricin in human-derived breast cancer cells in vitro and in nude mice in vivo.
British journal of cancer 2004;91(7):1364-71.
2004: Bruno Morgan; Mark A Horsfield; William P Steward
The role of imaging in the clinical development of antiangiogenic agents.
Hematology/oncology clinics of North America 2004;18(5):1183-206, x.
2004: Mark J Anderton; Margaret M Manson; Richard D Verschoyle; Andreas J Gescher; John H Lamb; Peter B Farmer; William P Steward; Marion L Williams
Pharmacokinetics and tissue disposition of indole-3-carbinol and its acid condensation products after oral administration to mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(15):5233-41.
2004: Mark J Anderton; Margaret M Manson; Richard D Verschoyle; Andreas J Gescher; William P Steward; Marion L Williams; Donald E Mager
Physiological modeling of formulated and crystalline 3,3'-diindolylmethane pharmacokinetics following oral administration in mice.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(6):632-8.
2004: Giuseppe Garcea; Donald J L Jones; Raj Singh; Ashley R Dennison; Peter B Farmer; Ricky A Sharma; William P Steward; Andreas J Gescher; David P Berry
Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration.
British journal of cancer 2004;90(5):1011-5.
2004: Stewart Sale; Richard D Verschoyle; David J Boocock; Donald J L Jones; N Wilsher; Ketan Chatrabhuj Ruparelia; Gerry A Potter; Peter B Farmer; William P Steward; Andreas J Gescher
Pharmacokinetics in mice and growth-inhibitory properties of the putative cancer chemopreventive agent resveratrol and the synthetic analogue trans 3,4,5,4'-tetramethoxystilbene.
British journal of cancer 2004;90(3):736-44.
2003: M A L Moneef; BT Sherwood; Karen J Bowman; Roger C Kockelbergh; R Paul Symonds; William P Steward; J Kilian Mellon; George D D Jones
Measurements using the alkaline comet assay predict bladder cancer cell radiosensitivity.
British journal of cancer 2003;89(12):2271-6.
2003: Bruno Morgan; Anne L Thomas; Joachim Drevs; Jürgen Hennig; Martin Buchert; Asvina Jivan; Mark A Horsfield; Klaus Mross; Howard A Ball; Lucy Lee; William Mietlowski; Stefan Fuxuis; Clemens Unger; Ken O'Byrne; Andrew Henry; Graham R Cherryman; Dirk Laurent; Margaret Dugan; Dieter Marmé; William P Steward
Dynamic contrast-enhanced magnetic resonance imaging as a biomarker for the pharmacological response of PTK787/ZK 222584, an inhibitor of the vascular endothelial growth factor receptor tyrosine kinases, in patients with advanced colorectal cancer and liver metastases: results from two phase I studies.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2003;21(21):3955-64.
2003: Hong Cai; Richard D Verschoyle; William P Steward; Andreas J Gescher
Determination of the flavone tricin in human plasma by high-performance liquid chromatography.
Biomedical chromatography : BMC 2003;17(7):435-9.
2003: Andreas J Gescher; William P Steward
Relationship between mechanisms, bioavailibility, and preclinical chemopreventive efficacy of resveratrol: a conundrum.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2003;12(10):953-7.
2003: Ricky A Sharma; Angus G Dalgleish; William P Steward; Kenneth J O'Byrne
Angiogenesis and the immune response as targets for the prevention and treatment of colorectal cancer (review).
Oncology reports 2003;10(5):1625-31.
2003: Lucy K Smith; Johannes L Botha; A Benghiat; William P Steward
Latest trends in cancer incidence among UK South Asians in Leicester.
British journal of cancer 2003;89(1):70-3.
2003: Anne L Thomas; Bruno Morgan; Joachim Drevs; Clemens Unger; Bertram Wiedenmann; Udo Vanhoefer; Dirk Laurent; Margaret Dugan; William P Steward
Vascular endothelial growth factor receptor tyrosine kinase inhibitors: PTK787/ZK 222584.
Seminars in oncology 2003;30(3 Suppl 6):32-8.
2003: Alexandra J Colquhoun; George D D Jones; Manar Al Moneef; Karen J Bowman; Roger C Kockelbergh; R Paul Symonds; William P Steward; J Kilian Mellon
Improving and predicting radiosensitivity in muscle invasive bladder cancer.
The Journal of urology 2003;169(6):1983-92.
2003: Sarah Perkins; A R Clarke; William P Steward; Andreas J Gescher
Age-related difference in susceptibility of Apc(Min/+) mice towards the chemopreventive efficacy of dietary aspirin and curcumin.
British journal of cancer 2003;88(9):1480-3.
2003: Mark J Anderton; Rebekah Jukes; John H Lamb; Margaret M Manson; Andreas J Gescher; William P Steward; Marion L Williams
Liquid chromatographic assay for the simultaneous determination of indole-3-carbinol and its acid condensation products in plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;787(2):281-91.
2003: Andreas J Gescher; Ricky A Sharma; William P Steward
Cancer prevention and delay are as important as cure.
The lancet oncology 2003;4(2):72-3.
2002: Hari L Ratan; William P Steward; Andreas J Gescher; J Kilian Mellon
Resveratrol--a prostate cancer chemopreventive agent?
Urologic oncology 2002;7(6):223-7.
2002: Kenneth J O'Byrne; Anne L Thomas; Ricky A Sharma; Marios P Decatris; F Shields; S Beare; William P Steward
A phase I dose-escalating study of DaunoXome, liposomal daunorubicin, in metastatic breast cancer.
British journal of cancer 2002;87(1):15-20.
2002: Sarah Perkins; Richard D Verschoyle; Kirsti Hill; Ifat Parveen; Michael Threadgill; Ricky A Sharma; Marion L Williams; William P Steward; Andreas J Gescher
Chemopreventive efficacy and pharmacokinetics of curcumin in the min/+ mouse, a model of familial adenomatous polyposis.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2002;11(6):535-40.
2002: Christopher R Ireson; Donald J L Jones; Samantha Orr; Michael W H Coughtrie; David J Boocock; Marion L Williams; Peter B Farmer; William P Steward; Andreas J Gescher
Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2002;11(1):105-11.
2001: Ricky A Sharma; A L Harris; A G Dalgleish; William P Steward; K J O'Byrne
Angiogenesis as a biomarker and target in cancer chemoprevention.
The lancet oncology 2001;2(12):726-32.
2001: Simon M Plummer; KA Hill; Michael F W Festing; William P Steward; Andreas J Gescher; Ricky A Sharma
Clinical development of leukocyte cyclooxygenase 2 activity as a systemic biomarker for cancer chemopreventive agents.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2001;10(12):1295-9.
2001: Anne L Thomas; Ken O'Byrne; L Furber; K Jeffery; William P Steward
A phase II study of caelyx, liposomal doxorubicin: lack of activity in patients with advanced gastric cancer.
Cancer chemotherapy and pharmacology 2001;48(4):266-8.
2001: Ricky A Sharma; M M Eatock; C J Twelves; G Brown; H R McLelland; K T Clayton; K J O'Byrne; C Moyses; J Carmichael; William P Steward
Bioavailability study of oral and intravenous OGT 719, a novel nucleoside analogue with preferential activity in the liver.
Cancer chemotherapy and pharmacology 2001;48(3):197-201.
2001: Ricky A Sharma; Andreas J Gescher; JP Plastaras; Chiara Leuratti; Rajinder Singh; Barbara Gallacher-Horley; E Offord; Lawrence J Marnett; William P Steward; S M Plummer
Cyclooxygenase-2, malondialdehyde and pyrimidopurinone adducts of deoxyguanosine in human colon cells.
Carcinogenesis 2001;22(9):1557-60.
2001: Anne L Thomas; William P Steward
Recent advances in the nonsurgical treatment of upper gastrointestinal tract tumors.
Expert review of anticancer therapy 2001;1(2):258-68.
2001: Ricky A Sharma; A J Gescher; K J O'Byrne; William P Steward
Familiar drugs may prevent cancer.
Postgraduate medical journal 2001;77(910):492-7.
2001: Ricky A Sharma; H R McLelland; KA Hill; Christopher R Ireson; Stephanie A Euden; Margaret M Manson; Munir Pirmohamed; Lawrence J Marnett; Andreas J Gescher; William P Steward
Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(7):1894-900.
2001: Andreas J Gescher; Ricky A Sharma; William P Steward
Cancer chemoprevention by dietary constituents: a tale of failure and promise.
The lancet oncology 2001;2(6):371-9.
2001: Ricky A Sharma; Christopher R Ireson; Richard D Verschoyle; KA Hill; Marion L Williams; Chiara Leuratti; Margaret M Manson; Lawrence J Marnett; William P Steward; Andreas J Gescher
Effects of dietary curcumin on glutathione S-transferase and malondialdehyde-DNA adducts in rat liver and colon mucosa: relationship with drug levels.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(5):1452-8.
2001: Ricky A Sharma; William P Steward; K P West; David Hemingway
Toxic megacolon: remember cytomegalovirus.
Hospital medicine (London, England : 1998) 2001;62(3):178-9.
2001: Christopher R Ireson; Samantha Orr; Donald J L Jones; Richard D Verschoyle; Chang Kee Lim; JL Luo; Lynne M Howells; Simon M Plummer; Rebekah Jukes; M Williams; William P Steward; Andreas J Gescher
Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 production.
Cancer research 2001;61(3):1058-64.
2001: Ricky A Sharma; Margaret M Manson; A Gescher; William P Steward
Colorectal cancer chemoprevention: biochemical targets and clinical development of promising agents.
European journal of cancer (Oxford, England : 1990) 2001;37(1):12-22.
2000: Anne L Thomas; G Cox; Ricky A Sharma; William P Steward; F Shields; K Jeyapalan; S Muller; Kenneth J O'Byrne
Gemcitabine and paclitaxel associated pneumonitis in non-small cell lung cancer: report of a phase I/II dose-escalating study.
European journal of cancer (Oxford, England : 1990) 2000;36(18):2329-34.
2000: William P Steward; Anne L Thomas
Marimastat: the clinical development of a matrix metalloproteinase inhibitor.
Expert opinion on investigational drugs 2000;9(12):2913-22.
2000: Anne L Thomas; Ken O'Byrne; William P Steward
Chemotherapy for upper gastrointestinal tumours.
Postgraduate medical journal 2000;76(896):321-7.
2000: K J O'Byrne; Michael I Koukourakis; Alexandra Giatromanolaki; G Cox; Helen Turley; William P Steward; Kevin Gatter; A L Harris
Vascular endothelial growth factor, platelet-derived endothelial cell growth factor and angiogenesis in non-small-cell lung cancer.
British journal of cancer 2000;82(8):1427-32.
2000: K J O'Byrne; A G Dalgleish; M J Browning; William P Steward; A L Harris
The relationship between angiogenesis and the immune response in carcinogenesis and the progression of malignant disease.
European journal of cancer (Oxford, England : 1990) 2000;36(2):151-69.
1999: William P Steward
Marimastat (BB2516): current status of development.
Cancer chemotherapy and pharmacology 1999;43 Suppl():S56-60.
1999: Ken O'Byrne; William P Steward
The role of chemotherapy in the treatment of adult soft tissue sarcomas.
Oncology 1999;56(1):13-23.
1998: Ken O'Byrne; William P Steward
The role of adjuvant chemotherapy in the treatment of adult soft tissue sarcomas.
Critical reviews in oncology/hematology 1998;27(3):221-7.
1998: William P Steward; Joachim von Pawel; Ulrich Gatzemeier; P Woll; N Thatcher; Gabriele Koschel; luke clancy; J Verweij; R de Wit; W Pfeifer; J Fennelly; M von Eiff; J Frisch
Effects of granulocyte-macrophage colony-stimulating factor and dose intensification of V-ICE chemotherapy in small-cell lung cancer: a prospective randomized study of 300 patients.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998;16(2):642-50.
1998: William P Steward
Combination studies with gemcitabine in the treatment of non-small-cell lung cancer.
British journal of cancer 1998;78 Suppl 3():15-9.