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Graeme Bolger

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Louise C Pyle; Aixia Ren; Eric J Sorscher; Graeme B Bolger; John P Clancy; Annette Ehrhardt; Lijuan Fan; Yao Li; Lisa High Mitchell; Anjaparavanda P Naren; Steven M Rowe
Regulatory domain phosphorylation to distinguish the mechanistic basis underlying acute CFTR modulators.
Hannah Murdoch; James C Norman; Anke Prinz; Suryakiran Vadrevu; Graeme B Bolger; Allan J Dunlop; Enno Klussmann; Miles D Houslay
Interaction between LIS1 and PDE4, and its role in cytoplasmic dynein function.
Kirsty F Mackenzie; Emma C Topping; Bozena Bugaj-Gaweda; Chengjun Deng; York-Fong Cheung; Aileen E Olsen; Cecil R Stockard; Lisa High Mitchell; George S Baillie; William E Grizzle; Michael De Vivo; Miles D Houslay; Daguang Wang; Graeme B Bolger
Human PDE4A8, a novel brain-expressed PDE4 cAMP-specific phosphodiesterase that has undergone rapid evolutionary change.

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All Publications

2011: Louise C Pyle; Aixia Ren; Eric J Sorscher; Graeme B Bolger; John P Clancy; Annette Ehrhardt; Lijuan Fan; Yao Li; Lisa High Mitchell; Anjaparavanda P Naren; Steven M Rowe
Regulatory domain phosphorylation to distinguish the mechanistic basis underlying acute CFTR modulators.
American journal of physiology. Lung cellular and molecular physiology 2011;301(4):L587-97.
2011: Hannah Murdoch; James C Norman; Anke Prinz; Suryakiran Vadrevu; Graeme B Bolger; Allan J Dunlop; Enno Klussmann; Miles D Houslay
Interaction between LIS1 and PDE4, and its role in cytoplasmic dynein function.
Journal of cell science 2011;124(Pt 13):2253-66.
2008: Kirsty F Mackenzie; Emma C Topping; Bozena Bugaj-Gaweda; Chengjun Deng; York-Fong Cheung; Aileen E Olsen; Cecil R Stockard; Lisa High Mitchell; George S Baillie; William E Grizzle; Michael De Vivo; Miles D Houslay; Daguang Wang; Graeme B Bolger
Human PDE4A8, a novel brain-expressed PDE4 cAMP-specific phosphodiesterase that has undergone rapid evolutionary change.
The Biochemical journal 2008;411(2):361-9.
2007: K John Smith; George S Baillie; Eva I Hyde; Xiang Li; Thomas M Houslay; Angela McCahill; Allan J Dunlop; Graeme B Bolger; Enno Klussmann; David R Adams; Miles D Houslay
1H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling scaffold proteins, beta-arrestin and RACK1.
Cellular signalling 2007;19(12):2612-24.
2007: Hannah Murdoch; Shaun Mackie; Daniel M Collins; Elaine V Hill; Graeme B Bolger; Enno Klussmann; David J Porteous; J Kirsty Millar; Miles D Houslay
Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(35):9513-24.
2007: George S Baillie; David R Adams; Narinder Bhari; Thomas M Houslay; Suryakiran Vadrevu; Dong Meng; Xiang Li; Allan J Dunlop; Graeme Milligan; Graeme B Bolger; Enno Klussmann; Miles D Houslay
Mapping binding sites for the PDE4D5 cAMP-specific phosphodiesterase to the N- and C-domains of beta-arrestin using spot-immobilized peptide arrays.
The Biochemical journal 2007;404(1):71-80.
2006: Graeme B Bolger; George S Baillie; Xiang Li; Martin J Lynch; Pawel Herzyk; Ahmed Mohamed; Lisa High Mitchell; Angela McCahill; Christian Hundsrucker; Enno Klussmann; David R Adams; Miles D Houslay
Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5.
The Biochemical journal 2006;398(1):23-36.
2005: Pierre L Triozzi; Graeme B Bolger; Jeffrey Neidhart; John J Rinehart; Mansoor Saleh; Karen O Allen; Sandra Sellers; Mary J Waddell
Effect of docetaxel chemotherapy on the activity of a gonadotropin releasing hormone vaccine in patients with advanced prostate cancer.
The Prostate 2005;65(4):316-21.
2003: Graeme B Bolger; Angela McCahill; Elaine Huston; York-Fong Cheung; Theresa McSorley; George S Baillie; Miles D Houslay
The unique amino-terminal region of the PDE4D5 cAMP phosphodiesterase isoform confers preferential interaction with beta-arrestins.
The Journal of biological chemistry 2003;278(49):49230-8.
2003: Graeme B Bolger; Alexander H Peden; Michael R Steele; Carolynn MacKenzie; David G McEwan; Derek A Wallace; Elaine Huston; George S Baillie; Miles D Houslay
Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2.
The Journal of biological chemistry 2003;278(35):33351-63.
2003: Malcolm Shepherd; Theresa McSorley; Aileen E Olsen; Lee Ann Johnston; Neil C Thomson; George S Baillie; Miles D Houslay; Graeme B Bolger
Molecular cloning and subcellular distribution of the novel PDE4B4 cAMP-specific phosphodiesterase isoform.
The Biochemical journal 2003;370(Pt 2):429-38.
2002: Angela McCahill; Jim Warwicker; Graeme B Bolger; Miles D Houslay; Stephen J Yarwood
The RACK1 scaffold protein: a dynamic cog in cell response mechanisms.
Molecular pharmacology 2002;62(6):1261-73.
2002: Graeme B Bolger; Angela McCahill; Stephen J Yarwood; Michael R Steele; Jim Warwicker; Miles D Houslay
Delineation of RAID1, the RACK1 interaction domain located within the unique N-terminal region of the cAMP-specific phosphodiesterase, PDE4D5.
BMC biochemistry 2002;3():24.
2001: Michael R Steele; Angela McCahill; D S Thompson; Carolynn MacKenzie; N W Isaacs; Miles D Houslay; Graeme B Bolger
Identification of a surface on the beta-propeller protein RACK1 that interacts with the cAMP-specific phosphodiesterase PDE4D5.
Cellular signalling 2001;13(7):507-13.
2000: Simon MacKenzie; George S Baillie; Ian McPhee; Graeme B Bolger; Miles D Houslay
ERK2 mitogen-activated protein kinase binding, phosphorylation, and regulation of the PDE4D cAMP-specific phosphodiesterases. The involvement of COOH-terminal docking sites and NH2-terminal UCR regions.
The Journal of biological chemistry 2000;275(22):16609-17.
2000: Matthew B Beard; Aileen E Olsen; R E Jones; Suat Erdogan; Miles D Houslay; Graeme B Bolger
UCR1 and UCR2 domains unique to the cAMP-specific phosphodiesterase family form a discrete module via electrostatic interactions.
The Journal of biological chemistry 2000;275(14):10349-58.
2000: Aileen E Olsen; Graeme B Bolger
Physical mapping and promoter structure of the murine cAMP-specific phosphodiesterase pde4a gene.
Mammalian genome : official journal of the International Mammalian Genome Society 2000;11(1):41-5.
1999: Matthew B Beard; J C O'Connell; Graeme B Bolger; Miles D Houslay
The unique N-terminal domain of the cAMP phosphodiesterase PDE4D4 allows for interaction with specific SH3 domains.
FEBS letters 1999;460(1):173-7.
1999: Stephen J Yarwood; Michael R Steele; Grant Scotland; Miles D Houslay; Graeme B Bolger
The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform.
The Journal of biological chemistry 1999;274(21):14909-17.
1998: Simon MacKenzie; Stephen J Yarwood; Alexander H Peden; Graeme B Bolger; Richard G Vernon; Miles D Houslay
Stimulation of p70S6 kinase via a growth hormone-controlled phosphatidylinositol 3-kinase pathway leads to the activation of a PDE4A cyclic AMP-specific phosphodiesterase in 3T3-F442A preadipocytes.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(7):3549-54.
1998: Miles D Houslay; Michael Sullivan; Graeme B Bolger
The multienzyme PDE4 cyclic adenosine monophosphate-specific phosphodiesterase family: intracellular targeting, regulation, and selective inhibition by compounds exerting anti-inflammatory and antidepressant actions.
Advances in pharmacology (San Diego, Calif.) 1998;44():225-342.
1997: Elaine Huston; S Lumb; A Russell; C Catterall; AH Ross; Michael R Steele; Graeme B Bolger; Martin J Perry; RJ Owens; Miles D Houslay
Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3.
The Biochemical journal 1997;328 ( Pt 2)():549-58.
1997: Graeme B Bolger; Suat Erdogan; R E Jones; K Loughney; Grant Scotland; R Hoffmann; I Wilkinson; C Farrell; Miles D Houslay
Characterization of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene.
The Biochemical journal 1997;328 ( Pt 2)():539-48.
1997: Miles D Houslay; Grant Scotland; Suat Erdogan; Elaine Huston; Simon MacKenzie; J F McCallum; Ian McPhee; L Pooley; G Rena; A Ross; Matthew B Beard; A Peder; F Begg; I Wilkinson; Stephen J Yarwood; C Ackerman; Emma S Houslay; R Hoffman; P Engels; Michael Sullivan; Graeme B Bolger
Intracellular targeting, interaction with Src homology 3 (SH3) domains and rolipram-detected conformational switches in cAMP-specific PDE4A phosphodiesterase.
Biochemical Society transactions 1997;25(2):374-81.
1996: Elaine Huston; L Pooley; P Julien; Grant Scotland; Ian McPhee; Michael Sullivan; Graeme B Bolger; Miles D Houslay
The human cyclic AMP-specific phosphodiesterase PDE-46 (HSPDE4A4B) expressed in transfected COS7 cells occurs as both particulate and cytosolic species that exhibit distinct kinetics of inhibition by the antidepressant rolipram.
The Journal of biological chemistry 1996;271(49):31334-44.
1996: J C O'Connell; J F McCallum; Ian McPhee; J Wakefield; E S Houslay; W Wishart; Graeme B Bolger; M Frame; Miles D Houslay
The SH3 domain of Src tyrosyl protein kinase interacts with the N-terminal splice region of the PDE4A cAMP-specific phosphodiesterase RPDE-6 (RNPDE4A5).
The Biochemical journal 1996;318 ( Pt 1)():255-61.
1995: Ian McPhee; L Pooley; M Lobban; Graeme B Bolger; Miles D Houslay
Identification, characterization and regional distribution in brain of RPDE-6 (RNPDE4A5), a novel splice variant of the PDE4A cyclic AMP phosphodiesterase family.
The Biochemical journal 1995;310 ( Pt 3)():965-74.