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Clinton Stewart

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Fariba Navid; John C Panetta; Wilburn E Reddick; Sheri L Spunt; Clinton F Stewart; David Turner; Jianrong Wu; Sharyn D Baker; Catherine A Billups; Andrew M Davidoff; Demba Fofana; Wayne L Furman; Shuiying Hu; Wing Leung; M Beth McCarville; Lisa M McGregor; Victor M Santana
Phase I and clinical pharmacology study of bevacizumab, sorafenib, and low-dose cyclophosphamide in children and young adults with refractory/recurrent solid tumors.
Ibrahim Qaddoumi; Carlos Rodriguez-Galindo; Clinton F Stewart; Michael Tagen; Jianrong Wu; Catherine A Billups; Rachel Brennan; Tammy M Free; Vicki Given; Barrett G Haik; Kathleen J Helton; M Beth McCarville; Thomas E Merchant; Matthew W Wilson
Topotecan and vincristine combination is effective against advanced bilateral intraocular retinoblastoma and has manageable toxicity.
Kimberly Anne Wichlan; W Leung; C Li; D K Srivastava; Clinton F Stewart; N L Wright; R C Barfield; L C Bowman; R Handgretinger; E M Horwitz; gregory alan hale
A phase I/II study of CY and topotecan in patients with high-risk malignancies undergoing autologous hematopoietic cell transplantation: the St Jude long-term follow-up.

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2013: Fariba Navid; John C Panetta; Wilburn E Reddick; Sheri L Spunt; Clinton F Stewart; David Turner; Jianrong Wu; Sharyn D Baker; Catherine A Billups; Andrew M Davidoff; Demba Fofana; Wayne L Furman; Shuiying Hu; Wing Leung; M Beth McCarville; Lisa M McGregor; Victor M Santana
Phase I and clinical pharmacology study of bevacizumab, sorafenib, and low-dose cyclophosphamide in children and young adults with refractory/recurrent solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2013;19(1):236-46.
2012: Ibrahim Qaddoumi; Carlos Rodriguez-Galindo; Clinton F Stewart; Michael Tagen; Jianrong Wu; Catherine A Billups; Rachel Brennan; Tammy M Free; Vicki Given; Barrett G Haik; Kathleen J Helton; M Beth McCarville; Thomas E Merchant; Matthew W Wilson
Topotecan and vincristine combination is effective against advanced bilateral intraocular retinoblastoma and has manageable toxicity.
Cancer 2012;118(22):5663-70.
2012: Kimberly Anne Wichlan; W Leung; C Li; D K Srivastava; Clinton F Stewart; N L Wright; R C Barfield; L C Bowman; R Handgretinger; E M Horwitz; gregory alan hale
A phase I/II study of CY and topotecan in patients with high-risk malignancies undergoing autologous hematopoietic cell transplantation: the St Jude long-term follow-up.
Bone marrow transplantation 2012;47(11):1448-54.
2012: Anthony M Christensen; James M Hoffman; Scott C Howard; Alejandro R Molinelli; John C Panetta; Alberto S Pappo; Jennifer L Pauley; Ching-Hon Pui; Mary V Relling; Clinton F Stewart; Deborah A Ward; Kristine R Crews
Resumption of high-dose methotrexate after acute kidney injury and glucarpidase use in pediatric oncology patients.
Cancer 2012;118(17):4321-30.
2012: Wayne L Furman; Dana Hawkins; Peter J Houghton; Sandy Kovach; M Beth McCarville; Lisa M McGregor; Valerie McPherson; Mihaela Onciu; Catherine A Billups; Andrew M Davidoff; Clinton F Stewart; Jianrong Wu; Victor M Santana
A single-arm pilot phase II study of gefitinib and irinotecan in children with newly diagnosed high-risk neuroblastoma.
Investigational new drugs 2012;30(4):1660-70.
2012: Jena J Steinle; Clinton F Stewart; Karin Emmons Thompson; Jordan Toutounchian; Fan Wang; J Scott Williams; Barrett G Haik; J Scott Jackson; Dianna Johnson; Timothy D Mandrell; Carl Soderland; C Ryan Yates; Qiuhua Zhang; Matthew W Wilson
Intra-ophthalmic artery chemotherapy triggers vascular toxicity through endothelial cell inflammation and leukostasis.
Investigative ophthalmology & visual science 2012;53(4):2439-45.
2012: B Szymanska; Urszula Wilczynska-Kalak; C Patrick Reynolds; Clinton F Stewart; Ingrid Boehm; Hernan Carol; Daniel Groepper; Min H Kang; Natalia L Liem; Richard B Lock
Pharmacokinetic modeling of an induction regimen for in vivo combined testing of novel drugs against pediatric acute lymphoblastic leukemia xenografts.
PloS one 2012;7(3):e33894.
2011: Julie R Park; Victor M Santana; Jeffrey R Scott; Peter J Shaw; Clinton F Stewart; Susan Cohn; Wendy B London; Arlene Naranjo; Katherine K Matthay
Pilot induction regimen incorporating pharmacokinetically guided topotecan for treatment of newly diagnosed high-risk neuroblastoma: a Children's Oncology Group study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011;29(33):4351-7.
2011: Matthew W Wilson; Jacquelyn Buchanan; Sharon Frase; Barrett G Haik; John S Jackson; Timothy D Mandrell; Blanca X Phillips; Jena J Steinle; Clinton F Stewart; Fan Wang; J Scott Williams
Real-time ophthalmoscopic findings of superselective intraophthalmic artery chemotherapy in a nonhuman primate model.
Archives of ophthalmology 2011;129(11):1458-65.
2011: Jennifer M Atkinson; Nidal Boulos; Angel Montero Carcaboso; Chris Eden; David W Ellison; Clementine Féau; Amar Gajjar; Paul Gibson; R Kiplin Guy; Robert A Johnson; Dimpy Koul; Tanya A Kranenburg; Kumarasamypet M Mohankumar; Timothy Phoenix; Helen M Poppleton; Waldemar Priebe; Anang A Shelat; Clinton F Stewart; Yiai Tong; Karen Wright; W K Alfred Yung; Liqin Zhu; Leggy Arnold; Richard J Gilbertson
An integrated in vitro and in vivo high-throughput screen identifies treatment leads for ependymoma.
Cancer cell 2011;20(3):384-99.
2011: Maryam Fouladi; Amar Gajjar; James M Boyett; Tim Demuth; Stewart Goldman; Sridharan Gururangan; Mehmet Kocak; Larry E Kun; James Olson; Arzu Onar-Thomas; Roger J Packer; Clinton F Stewart; Lars M Wagner; Richard J Gilbertson
Phase I trial of MK-0752 in children with refractory CNS malignancies: a pediatric brain tumor consortium study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011;29(26):3529-34.
2011: Feng Bai; Alberto Broniscer; Jennifer Johnson; Fan Wang; Lei Yang; Clinton F Stewart
Determination of vandetanib in human plasma and cerebrospinal fluid by liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS).
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2011;879(25):2561-6.
2011: Amit Khatri; Richard C Brundage; M Waleed Gaber; Suzan K Hanna; Michael D Naimark; Clinton F Stewart; Mark N Kirstein
Effect of radiation on the penetration of irinotecan in rat cerebrospinal fluid.
Cancer chemotherapy and pharmacology 2011;68(3):721-31.
2011: Fan Zhang; Stacy L Throm; Laura L Murley; Laura A Miller; D Steven Zatechka; R Kiplin Guy; Rachel Kennedy; Clinton F Stewart
MDM2 antagonist nutlin-3a reverses mitoxantrone resistance by inhibiting breast cancer resistance protein mediated drug transport.
Biochemical pharmacology 2011;82(1):24-34.
2011: Ian F Pollack; Clinton F Stewart; Mehmet Kocak; Tina Young Poussaint; Alberto Broniscer; Anu Banerjee; James G Douglas; Larry E Kun; James M Boyett; J Russell Geyer
A phase II study of gefitinib and irradiation in children with newly diagnosed brainstem gliomas: a report from the Pediatric Brain Tumor Consortium.
Neuro-oncology 2011;13(3):290-7.
2011: Rochelle Bagatell; Wendy B London; Lars M Wagner; Stephan D Voss; Clinton F Stewart; John M Maris; Cynthia Kretschmar; Susan Cohn
Phase II study of irinotecan and temozolomide in children with relapsed or refractory neuroblastoma: a Children's Oncology Group study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011;29(2):208-13.
2011: Mohamed A Elmeliegy; Angel M Carcaboso; Michael Tagen; Feng Bai; Clinton F Stewart
Role of ATP-binding cassette and solute carrier transporters in erlotinib CNS penetration and intracellular accumulation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(1):89-99.
2010: J Russell Geyer; Clinton F Stewart; Mehmet Kocak; Alberto Broniscer; Peter Phillips; James G Douglas; Susan M Blaney; Roger J Packer; Sri Gururangan; Anu Banerjee; Mark W Kieran; Larry E Kun; Richard J Gilbertson; James M Boyett
A phase I and biology study of gefitinib and radiation in children with newly diagnosed brain stem gliomas or supratentorial malignant gliomas.
European journal of cancer (Oxford, England : 1990) 2010;46(18):3287-93.
2010: Gareth J Veal; Christine M Hartford; Clinton F Stewart
Clinical pharmacology in the adolescent oncology patient.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(32):4790-9.
2010: Trevor McKibbin; Wei Zhao; Michael Tagen; Najat C Daw; Wayne L Furman; Lisa M McGregor; J Russell Geyer; Jeffrey W Allen; Clinton F Stewart
Epidermal growth factor receptor polymorphisms and risk for toxicity in paediatric patients treated with gefitinib.
European journal of cancer (Oxford, England : 1990) 2010;46(11):2045-51.
2010: Trevor McKibbin; John C Panetta; Maryam Fouladi; Amar Gajjar; Feng Bai; M Fatih Okcu; Clinton F Stewart
Clinical pharmacokinetics of amifostine and WR1065 in pediatric patients with medulloblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(3):1049-57.
2009: Shannon R Christiansen; Alberto Broniscer; J Carl Panetta; Clinton F Stewart
Pharmacokinetics of erlotinib for the treatment of high-grade glioma in a pediatric patient with cystic fibrosis: case report and review of the literature.
Pharmacotherapy 2009;29(7):858-66.
2009: Lars M Wagner; Judith G Villablanca; Clinton F Stewart; Kristine R Crews; Susan Groshen; Charles Patrick Reynolds; Julie R Park; John M Maris; Randall A Hawkins; Heike E Daldrup-Link; Hollie A Jackson; Katherine K Matthay
Phase I trial of oral irinotecan and temozolomide for children with relapsed high-risk neuroblastoma: a new approach to neuroblastoma therapy consortium study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(8):1290-6.
2009: Clinton F Stewart
Treating children with acute lymphoblastic leukemia and Down syndrome: pharmacokinetics provides insight into vincristine therapy.
Pediatric blood & cancer 2009;52(1):1-2.
2008: Maryam Fouladi; Murali Chintagumpala; David Ashley; Stewart J Kellie; Sridharan Gururangan; Tim Hassall; Lindsey Gronewold; Clinton F Stewart; Dana Wallace; Alberto Broniscer; gregory alan hale; Kimberly Anne Wichlan; Thomas E Merchant; Brannon Morris; Matthew J Krasin; Larry E Kun; James M Boyett; Amar Gajjar
Amifostine protects against cisplatin-induced ototoxicity in children with average-risk medulloblastoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(22):3749-55.
2008: Vishal S Narang; Charles Fraga; Narendra Kumar; Jun Shen; Stacy Throm; Clinton F Stewart; Christopher M Waters
Dexamethasone increases expression and activity of multidrug resistance transporters at the rat blood-brain barrier.
American journal of physiology. Cell physiology 2008;295(2):C440-50.
2008: Fariba Navid; Robbin Christensen; Patton Minkin; Clinton F Stewart; Wayne L Furman; Sharyn Baker
Stability of sunitinib in oral suspension.
The Annals of pharmacotherapy 2008;42(7):962-6.
2008: Tobey J MacDonald; Clinton F Stewart; Mehmet Kocak; Stewart Goldman; Richard G Ellenbogen; Peter Phillips; Deborah Lafond; Tina Young Poussaint; Mark W Kieran; James M Boyett; Larry E Kun
Phase I clinical trial of cilengitide in children with refractory brain tumors: Pediatric Brain Tumor Consortium Study PBTC-012.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(6):919-24.
2008: Sridharan Gururangan; Christopher D Turner; Clinton F Stewart; Melinda O'Shaughnessy; Mehmet Kocak; Tina Young Poussaint; Peter C Phillips; Stewart Goldman; Roger Packer; Ian F Pollack; Susan M Blaney; Verena Karsten; Stanton L Gerson; James M Boyett; Henry S Friedman; Larry E Kun
Phase I trial of VNP40101M (Cloretazine) in children with recurrent brain tumors: a pediatric brain tumor consortium study.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(4):1124-30.
2008: Lars M Wagner; Kristine R Crews; Clinton F Stewart; Carlos Rodriguez-Galindo; René Y McNall-Knapp; Karen H Albritton; Alberto S Pappo; Wayne L Furman
Reducing irinotecan-associated diarrhea in children.
Pediatric blood & cancer 2008;50(2):201-7.
2008: John C Panetta; Paula Schaiquevich; Victor M Santana; Clinton F Stewart
Using pharmacokinetic and pharmacodynamic modeling and simulation to evaluate importance of schedule in topotecan therapy for pediatric neuroblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(1):318-25.
2007: Alberto Broniscer; Sridharan Gururangan; Tobey J MacDonald; Stewart Goldman; Roger J Packer; Clinton F Stewart; Dana Wallace; Mary K Danks; Henry S Friedman; Tina Young Poussaint; Larry E Kun; James M Boyett; Amar Gajjar
Phase I trial of single-dose temozolomide and continuous administration of o6-benzylguanine in children with brain tumors: a pediatric brain tumor consortium report.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(22 Pt 1):6712-8.
2007: Paula Schaiquevich; John C Panetta; Lisa C Iacono; Burgess B Freeman; Victor M Santana; Amar Gajjar; Clinton F Stewart
Population pharmacokinetic analysis of topotecan in pediatric cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(22 Pt 1):6703-11.
2007: Maryam Fouladi; Fred H Laningham; Jianrong Wu; Melinda A O'Shaughnessy; Kristen Molina; Alberto Broniscer; Sheri L Spunt; Inga Luckett; Clinton F Stewart; Peter J Houghton; Richard J Gilbertson; Wayne L Furman
Phase I study of everolimus in pediatric patients with refractory solid tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(30):4806-12.
2007: Jeffrey A Meyerhardt; jeffrey clark; Jeffrey G Supko; Joseph P Eder; Shuji Ogino; Clinton F Stewart; Ferdinando D'Amato; Janet Dancey; Peter C Enzinger; Andrew X Zhu; David P Ryan; Craig C Earle; Robert J Mayer; Ann Michelini; Kate Kinsella; Charlie S Fuchs
Phase I study of gefitinib, irinotecan, 5-fluorouracil and leucovorin in patients with metastatic colorectal cancer.
Cancer chemotherapy and pharmacology 2007;60(5):661-70.
2007: Monika L Metzger; Clinton F Stewart; Burgess B Freeman; Catherine A Billups; Fredric A Hoffer; Jianrong Wu; Max J Coppes; Ronald Grant; Murali Chintagumpala; Elizabeth A Mullen; Carlos Alvarado; Najat C Daw; Jeffrey S Dome
Topotecan is active against Wilms' tumor: results of a multi-institutional phase II study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(21):3130-6.
2007: Kazumasa Takenaka; Jessica A Morgan; George L Scheffer; Masashi Adachi; Clinton F Stewart; Daxi Sun; Markos Leggas; Karin F K Ejendal; Christine A Hrycyna; John D Schuetz
Substrate overlap between Mrp4 and Abcg2/Bcrp affects purine analogue drug cytotoxicity and tissue distribution.
Cancer research 2007;67(14):6965-72.
2007: Paxton V Dickson; John B Hamner; Thomas L Sims; Charles H Fraga; Catherine Y C Ng; Surender Rajasekeran; Nikolaus L Hagedorn; M Beth McCarville; Clinton F Stewart; Andrew M Davidoff
Bevacizumab-induced transient remodeling of the vasculature in neuroblastoma xenografts results in improved delivery and efficacy of systemically administered chemotherapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(13):3942-50.
2007: Clinton F Stewart; John C Panetta; Melinda A O'Shaughnessy; Stacy L Throm; Charles H Fraga; Thandranese Owens; Tiebin Liu; Catherine A Billups; Carlos Rodriguez-Galindo; Amar Gajjar; Wayne L Furman; Lisa M McGregor
UGT1A1 promoter genotype correlates with SN-38 pharmacokinetics, but not severe toxicity in patients receiving low-dose irinotecan.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(18):2594-600.
2007: Feng Bai; Patton Minkin; Charles H Fraga; Melinda A O'Shaughnessy; Sridharan Gururangan; Clinton F Stewart
Determination of Cloretazine (VNP40101M) and its active metabolite (VNP4090CE) in human plasma by liquid chromatography electrospray tandem mass spectrometry (LC-ESI-MS/MS).
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;853(1-2):97-104.
2007: Paxton V Dickson; John B Hamner; Christian J Streck; Catherine Y C Ng; M Beth McCarville; Christopher Calabrese; Richard J Gilbertson; Clinton F Stewart; Christy M Wilson; M Waleed Gaber; Lawrence M Pfeffer; Stephen Xavier Skapek; Amit C Nathwani; Andrew M Davidoff
Continuous delivery of IFN-beta promotes sustained maturation of intratumoral vasculature.
Molecular cancer research : MCR 2007;5(6):531-42.
2007: Sheri L Spunt; Burgess B Freeman; Catherine A Billups; Valerie McPherson; Raja B Khan; Charles B Pratt; Clinton F Stewart
Phase I clinical trial of oxaliplatin in children and adolescents with refractory solid tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(16):2274-80.
2007: Alberto Broniscer; John C Panetta; Melinda O'Shaughnessy; Charles Fraga; Feng Bai; Matthew J Krasin; Amar Gajjar; Clinton F Stewart
Plasma and cerebrospinal fluid pharmacokinetics of erlotinib and its active metabolite OSI-420.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(5):1511-5.
2007: Paxton V Dickson; Nikolaus L Hagedorn; John B Hamner; Charles H Fraga; Catherine Y C Ng; Clinton F Stewart; Andrew M Davidoff
Interferon beta-mediated vessel stabilization improves delivery and efficacy of systemically administered topotecan in a murine neuroblastoma model.
Journal of pediatric surgery 2007;42(1):160-5; discussion 165.
2006: Yanli Zhuang; Charles H Fraga; K Elaine Hubbard; Nikolaus L Hagedorn; John C Panetta; Christopher M Waters; Clinton F Stewart
Topotecan central nervous system penetration is altered by a tyrosine kinase inhibitor.
Cancer research 2006;66(23):11305-13.
2006: Burgess B Freeman; Pamela Hinds; Lisa C Iacono; Bassem I Razzouk; Elizabeth Burghen; Clinton F Stewart
Pharmacokinetics and pharmacodynamics of intravenous epoetin alfa in children with cancer.
Pediatric blood & cancer 2006;47(5):572-9.
2006: Amar Gajjar; Murali Chintagumpala; David Ashley; Stewart J Kellie; Larry E Kun; Thomas E Merchant; Shiao Woo; Greg Wheeler; Valerie Ahern; Matthew J Krasin; Maryam Fouladi; Alberto Broniscer; Robert A Krance; gregory alan hale; Clinton F Stewart; Robert Dauser; Robert A Sanford; Christine Fuller; Ching Lau; James M Boyett; Dana Wallace; Richard J Gilbertson
Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial.
The lancet oncology 2006;7(10):813-20.
2006: Maryam Fouladi; Wayne L Furman; Thomas Chin; Burgess B Freeman; Lorina Dudkin; Clinton F Stewart; Mark Krailo; Rose Anne Speights; Ashish Ingle; Peter J Houghton; John Wright; Peter Charles Adamson; Susan M Blaney
Phase I study of depsipeptide in pediatric patients with refractory solid tumors: a Children's Oncology Group report.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(22):3678-85.
2006: Markos Leggas; John C Panetta; Yanli Zhuang; John D Schuetz; Brad Johnston; Feng Bai; Brian P Sorrentino; Sheng Zhou; Peter J Houghton; Clinton F Stewart
Gefitinib modulates the function of multiple ATP-binding cassette transporters in vivo.
Cancer research 2006;66(9):4802-7.
2006: Burgess B Freeman; Najat C Daw; J Russell Geyer; Wayne L Furman; Clinton F Stewart
Evaluation of gefitinib for treatment of refractory solid tumors and central nervous system malignancies in pediatric patients.
Cancer investigation 2006;24(3):310-7.
2006: Matthew W Wilson; Charles H Fraga; Christine E Fuller; Carlos Rodriguez-Galindo; John Mancini; Nikolaus L Hagedorn; Markos Leggas; Clinton F Stewart
Immunohistochemical detection of multidrug-resistant protein expression in retinoblastoma treated by primary enucleation.
Investigative ophthalmology & visual science 2006;47(4):1269-73.
2006: Burgess B Freeman; Lisa C Iacono; John C Panetta; Amar Gajjar; Clinton F Stewart
Using plasma topotecan pharmacokinetics to estimate topotecan exposure in cerebrospinal fluid of children with medulloblastoma.
Neuro-oncology 2006;8(2):89-95.
2006: Murali Chintagumpala; Henry S Friedman; Clinton F Stewart; James L Kepner; Roger E McLendon; Paul Modrich; Charles W McCluggage; Peter C Burger; Emi Holmes; Stephen Thompson; James Rutka; Jeff Michalski; Shiao Woo; Susan M Blaney; Larry E Kun; Marc E Horowitz
A phase II window trial of procarbazine and topotecan in children with high-grade glioma: a report from the children's oncology group.
Journal of neuro-oncology 2006;77(2):193-8.
2006: P Kellie Turner; Lisa C Iacono; John C Panetta; Victor M Santana; Najat C Daw; Amar Gajjar; Clinton F Stewart
Development and validation of limited sampling models for topotecan lactone pharmacokinetic studies in children.
Cancer chemotherapy and pharmacology 2006;57(4):475-82.
2006: Feng Bai; Burgess B Freeman; Charles H Fraga; Maryam Fouladi; Clinton F Stewart
Determination of lapatinib (GW572016) in human plasma by liquid chromatography electrospray tandem mass spectrometry (LC-ESI-MS/MS).
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2006;831(1-2):169-75.
2006: Wayne L Furman; Kristine R Crews; Catherine A Billups; Jianrong Wu; Amar Gajjar; Najat C Daw; Christian C Patrick; Carlos Rodriguez-Galindo; Clinton F Stewart; Jeffrey S Dome; John C Panetta; Peter J Houghton; Victor M Santana
Cefixime allows greater dose escalation of oral irinotecan: a phase I study in pediatric patients with refractory solid tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(4):563-70.
2006: Alberto Broniscer; Murali Chintagumpala; Maryam Fouladi; Matthew J Krasin; Mehmet Kocak; Daniel Bowers; Lisa C Iacono; Thomas E Merchant; Clinton F Stewart; Peter J Houghton; Larry E Kun; Davonna Ledet; Amar Gajjar
Temozolomide after radiotherapy for newly diagnosed high-grade glioma and unfavorable low-grade glioma in children.
Journal of neuro-oncology 2006;76(3):313-9.
2006: Susannah E Motl; Yanli Zhuang; Christopher M Waters; Clinton F Stewart
Pharmacokinetic considerations in the treatment of CNS tumours.
Clinical pharmacokinetics 2006;45(9):871-903.
2006: Claire Graham; Chandra Tucker; Jeremy Creech; Edward Favours; Catherine A Billups; Tiebin Liu; Maryam Fouladi; Burgess B Freeman; Clinton F Stewart; Peter J Houghton
Evaluation of the antitumor efficacy, pharmacokinetics, and pharmacodynamics of the histone deacetylase inhibitor depsipeptide in childhood cancer models in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(1):223-34.
2006: Jeannine S McCune; Denise Adams; Alan C Homans; Ann Guillot; Lisa C Iacono; Clinton F Stewart
Cyclophosphamide disposition in an anephric child.
Pediatric blood & cancer 2006;46(1):99-104.
2006: Carlos Rodriguez-Galindo; Kristine R Crews; Clinton F Stewart; Wayne L Furman; John C Panetta; Najat C Daw; Alvida M Cain; Ming Tan; Peter H Houghton; Victor M Santana
Phase I study of the combination of topotecan and irinotecan in children with refractory solid tumors.
Cancer chemotherapy and pharmacology 2006;57(1):15-24.
2005: Christopher L Morton; Lisa Iacono; Janice L Hyatt; Kody R Taylor; Pamela J Cheshire; Peter J Houghton; Mary K Danks; Clinton F Stewart; Philip Potter
Activation and antitumor activity of CPT-11 in plasma esterase-deficient mice.
Cancer chemotherapy and pharmacology 2005;56(6):629-36.
2005: Najat C Daw; Wayne L Furman; Clinton F Stewart; Lisa C Iacono; Mark Krailo; Mark L Bernstein; Janet E Dancey; Rose Anne Speights; Susan M Blaney; James M Croop; Gregory H Reaman; Peter Charles Adamson
Phase I and pharmacokinetic study of gefitinib in children with refractory solid tumors: a Children's Oncology Group Study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(25):6172-80.
2005: Victor M Santana; Wayne L Furman; Catherine A Billups; Fredric A Hoffer; Andrew M Davidoff; Peter J Houghton; Clinton F Stewart
Improved response in high-risk neuroblastoma with protracted topotecan administration using a pharmacokinetically guided dosing approach.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(18):4039-47.
2005: Mark N Kirstein; John C Panetta; Amar Gajjar; Geeta Nair; Lisa C Iacono; Burgess B Freeman; Clinton F Stewart
Development of a pharmacokinetic limited sampling model for temozolomide and its active metabolite MTIC.
Cancer chemotherapy and pharmacology 2005;55(5):433-8.
2005: Sheng Zhou; Yang Zong; Paul A Ney; Geeta Nair; Clinton F Stewart; Brian P Sorrentino
Increased expression of the Abcg2 transporter during erythroid maturation plays a role in decreasing cellular protoporphyrin IX levels.
Blood 2005;105(6):2571-6.
2005: Heidi H Gillenwater; Jeannine S McCune; Celeste Lindley; Stephanie R Faucette; Stacy S Shord; Angela Donahue; Mark A Socinski; Clinton F Stewart; William C Zamboni; Mark N Kirstein; Dominic Moore
A phase I trial defining the maximum tolerated systemic exposure of topotecan in combination with Carboplatin and Etoposide in extensive stage small cell lung cancer.
Cancer investigation 2005;23(6):511-9.
2004: Kristine R Crews; Clinton F Stewart; Tiebin Liu; Carlos Rodriguez-Galindo; Victor M Santana; Najat C Daw
Effect of fractionated ifosfamide on the pharmacokinetics of irinotecan in pediatric patients with osteosarcoma.
Journal of pediatric hematology/oncology 2004;26(11):764-7.
2004: Clinton F Stewart; Markos Leggas; John D Schuetz; John C Panetta; Pamela J Cheshire; Jennifer Peterson; Najat C Daw; Jesse J Jenkins; Richard Gilbertson; Glen S Germain; Franklin C Harwood; Peter J Houghton
Gefitinib enhances the antitumor activity and oral bioavailability of irinotecan in mice.
Cancer research 2004;64(20):7491-9.
2004: Justyna T Romer; Hiromichi Kimura; Susan M Magdaleno; Ken Sasai; Christine Fuller; Helen Baines; Michele Connelly; Clinton F Stewart; Stephen Gould; Lee L Rubin; Tom Curran
Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.
Cancer cell 2004;6(3):229-40.
2004: Lisa C Iacono; Denise Adams; Alan C Homans; Ann Guillot; Jeannine S McCune; Clinton F Stewart
Topotecan disposition in an anephric child.
Journal of pediatric hematology/oncology 2004;26(9):596-600.
2004: Markos Leggas; Masashi Adachi; George L Scheffer; Daxi Sun; peter wielinga; Guoqing Du; Kelly E Mercer; Yanli Zhuang; John C Panetta; Brad Johnston; Rik J Scheper; Clinton F Stewart; John D Schuetz
Mrp4 confers resistance to topotecan and protects the brain from chemotherapy.
Molecular and cellular biology 2004;24(17):7612-21.
2004: Markos Leggas; Yanli Zhuang; Jonathan Welden; Zack Self; Christopher M Waters; Clinton F Stewart
Microbore HPLC method with online microdialysis for measurement of topotecan lactone and carboxylate in murine CSF.
Journal of pharmaceutical sciences 2004;93(9):2284-95.
2004: Clinton F Stewart; Lisa C Iacono; Murali Chintagumpala; Stewart J Kellie; David Ashley; William C Zamboni; Mark N Kirstein; Maryam Fouladi; Louis G Seele; Dana Wallace; Peter J Houghton; Amar Gajjar
Results of a phase II upfront window of pharmacokinetically guided topotecan in high-risk medulloblastoma and supratentorial primitive neuroectodermal tumor.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(16):3357-65.
2004: Peter J Houghton; Glen S Germain; Franklin C Harwood; John D Schuetz; Clinton F Stewart; Elisabeth Buchdunger; Peter Traxler
Imatinib mesylate is a potent inhibitor of the ABCG2 (BCRP) transporter and reverses resistance to topotecan and SN-38 in vitro.
Cancer research 2004;64(7):2333-7.
2004: Najat C Daw; Victor M Santana; Lisa C Iacono; Wayne L Furman; Dana R Hawkins; Peter J Houghton; John C Panetta; Amar Gajjar; Clinton F Stewart
Phase I and pharmacokinetic study of topotecan administered orally once daily for 5 days for 2 consecutive weeks to pediatric patients with refractory solid tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(5):829-37.
2004: P Kellie Turner; Janet A Houghton; István Peták; David M Tillman; Leslie Douglas; Lee Schwartzberg; Catherine A Billups; John C Panetta; Clinton F Stewart
Interferon-gamma pharmacokinetics and pharmacodynamics in patients with colorectal cancer.
Cancer chemotherapy and pharmacology 2004;53(3):253-60.
2004: Lars M Wagner; Kristine R Crews; Lisa C Iacono; Peter J Houghton; Christine E Fuller; M Beth McCarville; Robert E Goldsby; Karen H Albritton; Clinton F Stewart; Victor M Santana
Phase I trial of temozolomide and protracted irinotecan in pediatric patients with refractory solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(3):840-8.
2004: Ramsis K Benjamin; Fred H Hochberg; Elizabeth Fox; Peter M Bungay; William F Elmquist; Clinton F Stewart; James M Gallo; Jerry M Collins; Robert P Pelletier; John F de Groot; Robert C Hickner; Idil Cavus; Stuart A Grossman; O Michael Colvin
Review of microdialysis in brain tumors, from concept to application: first annual Carolyn Frye-Halloran symposium.
Neuro-oncology 2004;6(1):65-74.
2003: John C Panetta; Mark N Kirstein; Amar Gajjar; Geeta Nair; Maryam Fouladi; Richard L Heideman; Mark Wilkinson; Clinton F Stewart
Population pharmacokinetics of temozolomide and metabolites in infants and children with primary central nervous system tumors.
Cancer chemotherapy and pharmacology 2003;52(6):435-41.
2003: John C Panetta; Lisa C Iacono; Peter Charles Adamson; Clinton F Stewart
The importance of pharmacokinetic limited sampling models for childhood cancer drug development.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(14):5068-77.
2003: John C Panetta; Mark N Kirstein; Amar Gajjar; Geeta Nair; Maryam Fouladi; Clinton F Stewart
A mechanistic mathematical model of temozolomide myelosuppression in children with high-grade gliomas.
Mathematical biosciences 2003;186(1):29-41.
2003: ZoAnn E Dreyer; Richard Kadota; Clinton F Stewart; Henry S Friedman; Donald H Mahoney; Larry E Kun; Charles W McCluggage; Peter C Burger; James L Kepner; Richard L Heideman
Phase 2 study of idarubicin in pediatric brain tumors: Pediatric Oncology Group study POG 9237.
Neuro-oncology 2003;5(4):261-7.
2003: Amar Gajjar; Murali Chintagumpala; Daniel Bowers; Dana Jones-Wallace; Clinton F Stewart; Kristine R Crews
Effect of intrapatient dosage escalation of irinotecan on its pharmacokinetics in pediatric patients who have high-grade gliomas and receive enzyme-inducing anticonvulsant therapy.
Cancer 2003;97(9 Suppl):2374-80.
2003: Feng Bai; Mark N Kirstein; Suzan K Hanna; Lisa C Iacono; Brad Johnston; Clinton F Stewart
Determination of plasma topotecan and its metabolite N-desmethyl topotecan as both lactone and total form by reversed-phase liquid chromatography with fluorescence detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;784(2):225-32.
2003: Victor M Santana; William C Zamboni; Mark N Kirstein; Ming Tan; Tiebin Liu; Amar Gajjar; Peter J Houghton; Clinton F Stewart
A pilot study of protracted topotecan dosing using a pharmacokinetically guided dosing approach in children with solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(2):633-40.
2003: P Kellie Turner; Lisa C Iacono; Clinton F Stewart
Topoisomerase I interactive agents.
Cancer chemotherapy and biological response modifiers 2003;21():69-101.
2002: Helen M Dodds; Peter J Tobin; Clinton F Stewart; Pamela J Cheshire; Suzan Hanna; Peter Houghton; Laurent P Rivory
The importance of tumor glucuronidase in the activation of irinotecan in a mouse xenograft model.
The Journal of pharmacology and experimental therapeutics 2002;303(2):649-55.
2002: Kristine R Crews; Varsha Gandhi; Deo Kumar Srivastava; Bassem I Razzouk; Xin Tong; Frederick G. Behm; William Plunkett; Susana C Raimondi; Ching-Hon Pui; Jeffrey E Rubnitz; Clinton F Stewart; Raul C Ribeiro
Interim comparison of a continuous infusion versus a short daily infusion of cytarabine given in combination with cladribine for pediatric acute myeloid leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(20):4217-24.
2002: Markos Leggas; Clinton F Stewart; Michael H Woo; Maryam Fouladi; Pamela J Cheshire; Jennifer K Peterson; Henry S Friedman; Catherine A Billups; Peter J Houghton
Relation between Irofulven (MGI-114) systemic exposure and tumor response in human solid tumor xenografts.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(9):3000-7.
2002: Kristine R Crews; Clinton F Stewart; Dana Jones-Wallace; Stephen J Thompson; Peter J Houghton; Richard L Heideman; Maryam Fouladi; Daniel Bowers; Murali Chintagumpala; Amar Gajjar
Altered irinotecan pharmacokinetics in pediatric high-grade glioma patients receiving enzyme-inducing anticonvulsant therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(7):2202-9.
2002: Feng Bai; Mark N Kirstein; Suzan K Hanna; Clinton F Stewart
New liquid chromatographic assay with electrochemical detection for the measurement of amifostine and WR1065.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2002;772(2):257-65.
2002: Wayne L Furman; Clinton F Stewart; Mark Kirstein; James L Kepner; Mark L Bernstein; Faith H Kung; Teresa J Vietti; C Philip Steuber; David L Becton; Sylvain Baruchel; Charles Pratt
Protracted intermittent schedule of topotecan in children with refractory acute leukemia: a pediatric oncology group study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(6):1617-24.
2002: Mark N Kirstein; P Kellie Turner; Clinton F Stewart
Topoisomerase I interactive agents.
Cancer chemotherapy and biological response modifiers 2002;20():99-123.
2001: E J Yeoh; J M Cunningham; G C Yee; D Hunt; J A Houston; S L Richardson; Clinton F Stewart; Peter J Houghton; Laura C Bowman; Amar Gajjar
Topotecan-filgrastim combination is an effective regimen for mobilizing peripheral blood stem cells.
Bone marrow transplantation 2001;28(6):563-71.
2001: Mark N Kirstein; Peter J Houghton; Pamela J Cheshire; LB Richmond; A K Smith; Suzan K Hanna; Clinton F Stewart
Relation between 9-aminocamptothecin systemic exposure and tumor response in human solid tumor xenografts.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(2):358-66.
2001: Clinton F Stewart
Topoisomerase I interactive agents.
Cancer chemotherapy and biological response modifiers 2001;19():85-128.
2001: Jon D Herrington; J A Figueroa; Mark N Kirstein; William C Zamboni; Clinton F Stewart
Effect of hemodialysis on topotecan disposition in a patient with severe renal dysfunction.
Cancer chemotherapy and pharmacology 2001;47(1):89-93.
2000: Peter J Houghton; Clinton F Stewart; Pamela J Cheshire; LB Richmond; Mark N Kirstein; CA Poquette; Ming Tan; Henry S Friedman; Thomas P Brent
Antitumor activity of temozolomide combined with irinotecan is partly independent of O6-methylguanine-DNA methyltransferase and mismatch repair phenotypes in xenograft models.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(10):4110-8.
2000: Carlos Rodriguez-Galindo; KM Radomski; Clinton F Stewart; Wayne L Furman; Victor M Santana; Peter J Houghton
Clinical use of topoisomerase I inhibitors in anticancer treatment.
Medical and pediatric oncology 2000;35(4):385-402.
2000: Christopher L Morton; Monika Wierdl; L Oliver; Margaret K Ma; Mary K Danks; Clinton F Stewart; Julie L Eiseman; Philip Potter
Activation of CPT-11 in mice: identification and analysis of a highly effective plasma esterase.
Cancer research 2000;60(15):4206-10.
2000: David S Middlemas; Clinton F Stewart; Mark N Kirstein; CA Poquette; Henry S Friedman; Peter J Houghton; Thomas P Brent
Biochemical correlates of temozolomide sensitivity in pediatric solid tumor xenograft models.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(3):998-1007.
2000: Margaret K Ma; William C Zamboni; KM Radomski; Wayne L Furman; Victor M Santana; Peter J Houghton; Suzan K Hanna; A K Smith; Clinton F Stewart
Pharmacokinetics of irinotecan and its metabolites SN-38 and APC in children with recurrent solid tumors after protracted low-dose irinotecan.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(3):813-9.
1999: J Thompson; E O George; CA Poquette; Pamela J Cheshire; LB Richmond; S S de Graaf; M Ma; Clinton F Stewart; Peter J Houghton
Synergy of topotecan in combination with vincristine for treatment of pediatric solid tumor xenografts.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(11):3617-31.
1999: Wayne L Furman; Clinton F Stewart; CA Poquette; Charles B Pratt; Victor M Santana; William C Zamboni; Laura C Bowman; Margaret K Ma; Fredric A Hoffer; William H Meyer; Alberto S Pappo; AW Walter; Peter J Houghton
Direct translation of a protracted irinotecan schedule from a xenograft model to a phase I trial in children.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1999;17(6):1815-24.
1999: Richard Kadota; Clinton F Stewart; M Horn; John Frank Kuttesch; Peter C Burger; James L Kepner; Larry E Kun; Henry S Friedman; Richard L Heideman
Topotecan for the treatment of recurrent or progressive central nervous system tumors - a pediatric oncology group phase II study.
Journal of neuro-oncology 1999;43(1):43-7.
1999: William C Zamboni; Laura C Bowman; Ming Tan; Victor M Santana; Peter J Houghton; William H Meyer; Charles B Pratt; Richard L Heideman; Amar Gajjar; A S Pappo; Clinton F Stewart
Interpatient variability in bioavailability of the intravenous formulation of topotecan given orally to children with recurrent solid tumors.
Cancer chemotherapy and pharmacology 1999;43(6):454-60.
1999: William C Zamboni; Peter J Houghton; J L Hulstein; Mark N Kirstein; J Walsh; Pamela J Cheshire; Suzan K Hanna; Mary K Danks; Clinton F Stewart
Relationship between tumor extracellular fluid exposure to topotecan and tumor response in human neuroblastoma xenograft and cell lines.
Cancer chemotherapy and pharmacology 1999;43(4):269-76.
1998: Sylvie M Guichard; Christopher L Morton; Erik J Krull; Clinton F Stewart; Mary K Danks; Philip Potter
Conversion of the CPT-11 metabolite APC to SN-38 by rabbit liver carboxylesterase.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(12):3089-94.
1998: William C Zamboni; Amar Gajjar; T D Mandrell; S L Einhaus; Mary K Danks; W P Rogers; Richard L Heideman; Peter J Houghton; Clinton F Stewart
A four-hour topotecan infusion achieves cytotoxic exposure throughout the neuraxis in the nonhuman primate model: implications for treatment of children with metastatic medulloblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(10):2537-44.
1998: J Thompson; Clinton F Stewart; Peter J Houghton
Animal models for studying the action of topoisomerase I targeted drugs.
Biochimica et biophysica acta 1998;1400(1-3):301-19.
1998: Peter J Houghton; Clinton F Stewart; J Thompson; V M Santana; Wayne L Furman; Henry S Friedman
Extending principles learned in model systems to clinical trials design.
Oncology (Williston Park, N.Y.) 1998;12(8 Suppl 6):84-93.
1998: CA Pawlik; Peter J Houghton; Clinton F Stewart; Pamela J Cheshire; LB Richmond; Mary K Danks
Effective schedules of exposure of medulloblastoma and rhabdomyosarcoma xenografts to topotecan correlate with in vitro assays.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(8):1995-2002.
1998: William C Zamboni; Clinton F Stewart; J Thompson; Victor M Santana; Pamela J Cheshire; LB Richmond; X Luo; CA Poquette; Janet A Houghton; Peter J Houghton
Relationship between topotecan systemic exposure and tumor response in human neuroblastoma xenografts.
Journal of the National Cancer Institute 1998;90(7):505-11.
1998: William C Zamboni; Amar Gajjar; Richard L Heideman; J H Beijnen; H Rosing; Peter J Houghton; Clinton F Stewart
Phenytoin alters the disposition of topotecan and N-desmethyl topotecan in a patient with medulloblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(3):783-9.
1998: William C Zamboni; Clinton F Stewart; Pamela J Cheshire; LB Richmond; Suzan K Hanna; X Luo; CA Poquette; J P McGovren; Janet A Houghton; Peter J Houghton
Studies of the efficacy and pharmacology of irinotecan against human colon tumor xenograft models.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(3):743-53.
1998: Robert L Saylors; Clinton F Stewart; William C Zamboni; DA Wall; Beverly Bell; Kimo C Stine; Teresa J Vietti
Phase I study of topotecan in combination with cyclophosphamide in pediatric patients with malignant solid tumors: a Pediatric Oncology Group Study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998;16(3):945-52.
1998: William C Zamboni; Peter J Houghton; J Thompson; Pamela J Cheshire; Suzan K Hanna; LB Richmond; X Lou; Clinton F Stewart
Altered irinotecan and SN-38 disposition after intravenous and oral administration of irinotecan in mice bearing human neuroblastoma xenografts.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(2):455-62.
1998: William C Zamboni; Peter J Houghton; R K Johnson; J L Hulstein; WR Crom; Pamela J Cheshire; Suzan K Hanna; LB Richmond; X Luo; Clinton F Stewart
Probenecid alters topotecan systemic and renal disposition by inhibiting renal tubular secretion.
The Journal of pharmacology and experimental therapeutics 1998;284(1):89-94.
1997: J Thompson; William C Zamboni; Pamela J Cheshire; LB Richmond; X Luo; Janet A Houghton; Clinton F Stewart; Peter J Houghton
Efficacy of oral irinotecan against neuroblastoma xenografts.
Anti-cancer drugs 1997;8(4):313-22.
1997: J Thompson; William C Zamboni; Pamela J Cheshire; L Lutz; X Luo; Y Li; Janet A Houghton; Clinton F Stewart; Peter J Houghton
Efficacy of systemic administration of irinotecan against neuroblastoma xenografts.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(3):423-31.
1997: Clinton F Stewart; William C Zamboni; WR Crom; Peter J Houghton
Disposition of irinotecan and SN-38 following oral and intravenous irinotecan dosing in mice.
Cancer chemotherapy and pharmacology 1997;40(3):259-65.
1996: Peter J Houghton; Clinton F Stewart; William C Zamboni; J Thompson; X Luo; Mary K Danks; Janet A Houghton
Schedule-dependent efficacy of camptothecins in models of human cancer.
Annals of the New York Academy of Sciences 1996;803():188-201.
1996: DG Tubergen; Clinton F Stewart; Charles B Pratt; William C Zamboni; N Winick; Victor M Santana; Z A Dryer; J Kurtzberg; Beverly Bell; H Grier; Teresa J Vietti
Phase I trial and pharmacokinetic (PK) and pharmacodynamics (PD) study of topotecan using a five-day course in children with refractory solid tumors: a pediatric oncology group study.
Journal of pediatric hematology/oncology 1996;18(4):352-61.
1996: Wayne L Furman; Sharyn D Baker; Charles B Pratt; Jaime Rivera; William Evans; Clinton F Stewart
Escalating systemic exposure of continuous infusion topotecan in children with recurrent acute leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1996;14(5):1504-11.
1996: Clinton F Stewart; William C Zamboni; W R Crom; Amar Gajjar; Richard L Heideman; Wayne L Furman; William H Meyer; Peter J Houghton; Charles B Pratt
Topoisomerase I interactive drugs in children with cancer.
Investigational new drugs 1996;14(1):37-47.
1996: Sharyn D Baker; Richard L Heideman; W R Crom; John Frank Kuttesch; Amar Gajjar; Clinton F Stewart
Cerebrospinal fluid pharmacokinetics and penetration of continuous infusion topotecan in children with central nervous system tumors.
Cancer chemotherapy and pharmacology 1996;37(3):195-202.
1995: Sharyn D Baker; Randy M Wadkins; Clinton F Stewart; William T Beck; Mary K Danks
Cell cycle analysis of amount and distribution of nuclear DNA topoisomerase I as determined by fluorescence digital imaging microscopy.
Cytometry 1995;19(2):134-45.
1995: Janet A Houghton; Pamela J Cheshire; Christopher L Morton; Clinton F Stewart
Potentiation of 5-fluorouracil-leucovorin activity by alpha2a-interferon in colon adenocarcinoma xenografts.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(1):33-40.
1994: Clinton F Stewart; Sharyn D Baker; Richard L Heideman; D Jones; W R Crom; Charles B Pratt
Clinical pharmacodynamics of continuous infusion topotecan in children: systemic exposure predicts hematologic toxicity.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1994;12(9):1946-54.
1994: Clinton F Stewart
Use of etoposide in patients with organ dysfunction: pharmacokinetic and pharmacodynamic considerations.
Cancer chemotherapy and pharmacology 1994;34 Suppl():S76-83.
1993: John H Rodman; Mary Relling; Clinton F Stewart; Timothy W Synold; howard mcleod; C Kearns; N Stute; W R Crom; William Evans
Clinical pharmacokinetics and pharmacodynamics of anticancer drugs in children.
Seminars in oncology 1993;20(1):18-29.
1992: William Evans; John H Rodman; Mary Relling; W P Petros; Clinton F Stewart; Ching-Hon Pui; Jaime Rivera
Differences in teniposide disposition and pharmacodynamics in patients with newly diagnosed and relapsed acute lymphocytic leukemia.
The Journal of pharmacology and experimental therapeutics 1992;260(1):71-7.
1992: Peter J Houghton; Pamela J Cheshire; L Myers; Clinton F Stewart; Timothy W Synold; Janet A Houghton
Evaluation of 9-dimethylaminomethyl-10-hydroxycamptothecin against xenografts derived from adult and childhood solid tumors.
Cancer chemotherapy and pharmacology 1992;31(3):229-39.