Paul Stewart

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Sherlock M; Reulen R C; Alonso A Aragon; Ayuk J; Clayton R N; Sheppard M C; Hawkins M M; Bates A S; Stewart P M
ACTH deficiency, higher doses of hydrocortisone replacement, and radiotherapy are independent predictors of mortality in patients with acromegaly.
Morgan Stuart A; Sherlock Mark; Gathercole Laura L; Lavery Gareth G; Lenaghan Carol; Bujalska Iwona J; Laber David; Yu Alice; Convey Gemma; Mayers Rachel; Hegyi Krisztina; Sethi Jaswinder K; Stewart Paul M; Smith David M; Tomlinson Jeremy W
11beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle.
Vassiliadi Dimitra A; Barber Thomas M; Hughes Beverly A; McCarthy Mark I; Wass John A H; Franks Stephen; Nightingale Peter; Tomlinson Jeremy W; Arlt Wiebke; Stewart Paul M
Increased 5 alpha-reductase activity and adrenocortical drive in women with polycystic ovary syndrome.

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2009: Sherlock M; Reulen R C; Alonso A Aragon; Ayuk J; Clayton R N; Sheppard M C; Hawkins M M; Bates A S; Stewart P M
ACTH deficiency, higher doses of hydrocortisone replacement, and radiotherapy are independent predictors of mortality in patients with acromegaly.
The Journal of clinical endocrinology and metabolism 2009;94(11):4216-23.
2009: Morgan Stuart A; Sherlock Mark; Gathercole Laura L; Lavery Gareth G; Lenaghan Carol; Bujalska Iwona J; Laber David; Yu Alice; Convey Gemma; Mayers Rachel; Hegyi Krisztina; Sethi Jaswinder K; Stewart Paul M; Smith David M; Tomlinson Jeremy W
11beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle.
Diabetes 2009;58(11):2506-15.
2009: Vassiliadi Dimitra A; Barber Thomas M; Hughes Beverly A; McCarthy Mark I; Wass John A H; Franks Stephen; Nightingale Peter; Tomlinson Jeremy W; Arlt Wiebke; Stewart Paul M
Increased 5 alpha-reductase activity and adrenocortical drive in women with polycystic ovary syndrome.
The Journal of clinical endocrinology and metabolism 2009;94(9):3558-66.
2009: Edwards Nicola C; Steeds Richard P; Stewart Paul M; Ferro Charles J; Townend Jonathan N
Effect of spironolactone on left ventricular mass and aortic stiffness in early-stage chronic kidney disease: a randomized controlled trial.
Journal of the American College of Cardiology 2009;54(6):505-12.
2009: Krone Nils; Stewart Paul M
Adrenal function: An overlooked cause of glucocorticoid deficiency?
Nature reviews. Endocrinology 2009;5(7):362-3.
2009: Lawson Alexander J; Walker Elizabeth A; White Scott A; Dafforn Timothy R; Stewart Paul M; Ride Jonathan P
Mutations of key hydrophobic surface residues of 11 beta-hydroxysteroid dehydrogenase type 1 increase solubility and monodispersity in a bacterial expression system.
Protein science : a publication of the Protein Society 2009;18(7):1552-63.
2009: Sherlock M; Aragon Alonso A; Reulen R C; Ayuk J; Clayton R N; Holder G; Sheppard M C; Bates A; Stewart P M
Monitoring disease activity using GH and IGF-I in the follow-up of 501 patients with acromegaly.
Clinical endocrinology 2009;71(1):74-81.
2009: Ball A K; Sinclair A J; Curnow S J; Tomlinson J W; Burdon M A; Walker E A; Stewart P M; Nightingale P G; Clarke C E; Rauz S
Elevated cerebrospinal fluid (CSF) leptin in idiopathic intracranial hypertension (IIH): evidence for hypothalamic leptin resistance?
Clinical endocrinology 2009;70(6):863-9.
2009: Shaw Christopher S; Sherlock Mark; Stewart Paul M; Wagenmakers Anton J M
Adipophilin distribution and colocalization with lipid droplets in skeletal muscle.
Histochemistry and cell biology 2009;131(5):575-81.
2009: Stewart Paul M; Prescott Stephen M
Can licorice lick colon cancer?
The Journal of clinical investigation 2009;119(4):760-3.
2009: Sherlock M; Fernandez-Rodriguez E; Alonso A Aragon; Reulen R C; Ayuk J; Clayton R N; Holder G; Sheppard M C; Bates A; Stewart P M
Medical therapy in patients with acromegaly: predictors of response and comparison of efficacy of dopamine agonists and somatostatin analogues.
The Journal of clinical endocrinology and metabolism 2009;94(4):1255-63.
2009: Stewart Paul M; Clark Penelope M
The low-dose corticotropin-stimulation test revisited: the less, the better?
Nature clinical practice. Endocrinology & metabolism 2009;5(2):68-9.
2009: Stewart Paul M; Tomlinson Jeremy W
Selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 for patients with metabolic syndrome: is the target liver, fat, or both?
Diabetes 2009;58(1):14-5.
2009: Hammer Fabian; Stewart Paul M
Investigating hypertension in a young person.
BMJ (Clinical research ed.) 2009;338():b1043.
2009: Fernandez-Rodriguez Eva; Stewart Paul M; Cooper Mark S
The pituitary-adrenal axis and body composition.
Pituitary 2009;12(2):105-15.
2009: Ayuk John; Stewart Paul M
Mortality following pituitary radiotherapy.
Pituitary 2009;12(1):35-9.
2008: Zehnder Daniel; Quinkler Marcus; Eardley Kevin S; Bland Rosemary; Lepenies Julia; Hughes Susan V; Raymond Neil T; Howie Alexander J; Cockwell Paul; Stewart Paul M; Hewison Martin
Reduction of the vitamin D hormonal system in kidney disease is associated with increased renal inflammation.
Kidney international 2008;74(10):1343-53.
2008: Swali A; Walker E A; Lavery G G; Tomlinson J W; Stewart P M
11beta-Hydroxysteroid dehydrogenase type 1 regulates insulin and glucagon secretion in pancreatic islets.
Diabetologia 2008;51(11):2003-11.
2008: Tomlinson Jeremy W; Finney Joanne; Gay Christopher; Hughes Beverly A; Hughes Susan V; Stewart Paul M
Impaired glucose tolerance and insulin resistance are associated with increased adipose 11beta-hydroxysteroid dehydrogenase type 1 expression and elevated hepatic 5alpha-reductase activity.
Diabetes 2008;57(10):2652-60.
2008: Lavery Gareth G; Walker Elizabeth A; Tiganescu Ana; Ride Jon P; Shackleton Cedric H L; Tomlinson Jeremy W; Connell John M C; Ray David W; Biason-Lauber Anna; Malunowicz Ewa M; Arlt Wiebke; Stewart Paul M
Steroid biomarkers and genetic studies reveal inactivating mutations in hexose-6-phosphate dehydrogenase in patients with cortisone reductase deficiency.
The Journal of clinical endocrinology and metabolism 2008;93(10):3827-32.
2008: Shackleton C H L; Hughes B A; Lavery G G; Walker E A; Stewart P M
The corticosteroid metabolic profile of the mouse.
Steroids 2008;73(11):1066-76.
2008: Sinclair Alexandra J; Ball Alexandra K; Burdon Michael A; Clarke Carl E; Stewart Paul M; Curnow S John; Rauz Saaeha
Exploring the pathogenesis of IIH: an inflammatory perspective.
Journal of neuroimmunology 2008;201-202():212-20.
2008: Hardy R; Rabbitt E H; Filer A; Emery P; Hewison M; Stewart P M; Gittoes N J; Buckley C D; Raza K; Cooper M S
Local and systemic glucocorticoid metabolism in inflammatory arthritis.
Annals of the rheumatic diseases 2008;67(9):1204-10.
2008: Shackleton Cedric H L; Neres Marcos S; Hughes Beverly A; Stewart Paul M; Kater Claudio E
17-Hydroxylase/C17,20-lyase (CYP17) is not the enzyme responsible for side-chain cleavage of cortisol and its metabolites.
Steroids 2008;73(6):652-6.
2008: Tomlinson Jeremy W; Finney Joanne; Hughes Beverly A; Hughes Susan V; Stewart Paul M
Reduced glucocorticoid production rate, decreased 5alpha-reductase activity, and adipose tissue insulin sensitization after weight loss.
Diabetes 2008;57(6):1536-43.
2008: Ahmed Adeeba; Saksena Sushma; Sherlock Mark; Olliff Simon P; Elias Elwyn; Stewart Paul M
Induction of hepatic 11beta-hydroxysteroid dehydrogenase type 1 in patients with alcoholic liver disease.
Clinical endocrinology 2008;68(6):898-903.
2008: Bujalska I J; Gathercole L L; Tomlinson J W; Darimont C; Ermolieff J; Fanjul A N; Rejto P A; Stewart P M
A novel selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitor prevents human adipogenesis.
The Journal of endocrinology 2008;197(2):297-307.
2008: Bujalska Iwona J; Hewitt Kylie N; Hauton David; Lavery Gareth G; Tomlinson Jeremy W; Walker Elizabeth A; Stewart Paul M
Lack of hexose-6-phosphate dehydrogenase impairs lipid mobilization from mouse adipose tissue.
Endocrinology 2008;149(5):2584-91.
2008: Palermo Mario; Marazzi Maria Grazia; Hughes Beverly A; Stewart Paul M; Clayton Peter T; Shackleton Cedric H L
Human Delta4-3-oxosteroid 5beta-reductase (AKR1D1) deficiency and steroid metabolism.
Steroids 2008;73(4):417-23.
2008: Lavery Gareth G; Walker Elizabeth A; Turan Nil; Rogoff Daniela; Ryder Jeffery W; Shelton John M; Richardson James A; Falciani Francesco; White Perrin C; Stewart Paul M; Parker Keith L; McMillan Daniel R
Deletion of hexose-6-phosphate dehydrogenase activates the unfolded protein response pathway and induces skeletal myopathy.
The Journal of biological chemistry 2008;283(13):8453-61.
2008: Bhat B Ganesh; Hosea Natilie; Fanjul Andrea; Herrera Jocelyn; Chapman Justin; Thalacker Fred; Stewart Paul M; Rejto Paul A
Demonstration of proof of mechanism and pharmacokinetics and pharmacodynamic relationship with 4'-cyano-biphenyl-4-sulfonic acid (6-amino-pyridin-2-yl)-amide (PF-915275), an inhibitor of 11 -hydroxysteroid dehydrogenase type 1, in cynomolgus monkeys.
The Journal of pharmacology and experimental therapeutics 2008;324(1):299-305.
2008: Stewart Paul M; Stears Anna; Tomlinson Jeremy W; Brown Morris J
Regulation--the real threat to clinical research.
BMJ (Clinical research ed.) 2008;337():a1732.
2007: Tomlinson Jeremy W; Stewart Paul M
Modulation of glucocorticoid action and the treatment of type-2 diabetes.
Best practice & research. Clinical endocrinology & metabolism 2007;21(4):607-19.
2007: Alabraba Edward B; Taniere Philippe; Reynolds Gary M; Stewart Paul M; Wigmore Stephen J; Bramhall Simon R
Expression and functional consequences of oestrogen and progesterone receptors in human insulinomas.
Endocrine-related cancer 2007;14(4):1081-8.
2007: Lavery Gareth G; Hauton David; Hewitt Kylie N; Brice Sophie M; Sherlock Mark; Walker Elizabeth A; Stewart Paul M
Hypoglycemia with enhanced hepatic glycogen synthesis in recombinant mice lacking hexose-6-phosphate dehydrogenase.
Endocrinology 2007;148(12):6100-6.
2007: Fegan P Gerry; Sandeman Derek D; Krone Nils; Bosman Deborah; Wood Peter J; Stewart Paul M; Hanley Neil A
Cushing's syndrome in women with polycystic ovaries and hyperandrogenism.
Nature clinical practice. Endocrinology & metabolism 2007;3(11):778-83.
2007: Gathercole Laura L; Bujalska Iwona J; Stewart Paul M; Tomlinson Jeremy W
Glucocorticoid modulation of insulin signaling in human subcutaneous adipose tissue.
The Journal of clinical endocrinology and metabolism 2007;92(11):4332-9.
2007: Chan Junny; Rabbitt Elizabeth H; Innes Barbara A; Bulmer Judith N; Stewart Paul M; Kilby Mark D; Hewison Martin
Glucocorticoid-induced apoptosis in human decidua: a novel role for 11beta-hydroxysteroid dehydrogenase in late gestation.
The Journal of endocrinology 2007;195(1):7-15.
2007: Walker Elizabeth A; Ahmed Adeeba; Lavery Gareth G; Tomlinson Jeremy W; Kim So Youn; Cooper Mark S; Ride Jonathan P; Hughes Beverly A; Shackleton Cedric H L; McKiernan Patrick; Elias Elwyn; Chou Janice Y; Stewart Paul M
11beta-Hydroxysteroid Dehydrogenase Type 1 Regulation by Intracellular Glucose 6-Phosphate Provides Evidence for a Novel Link between Glucose Metabolism and Hypothalamo-Pituitary-Adrenal Axis Function.
The Journal of biological chemistry 2007;282(37):27030-6.
2007: Sinclair A J; Onyimba C U; Khosla P; Vijapurapu N; Tomlinson J W; Burdon M A; Stewart P M; Murray P I; Walker E A; Rauz S
Corticosteroids, 11beta-hydroxysteroid dehydrogenase isozymes and the rabbit choroid plexus.
Journal of neuroendocrinology 2007;19(8):614-20.
2007: Dhir Vivek; Ivison Hannah E; Krone Nils; Shackleton Cedric H L; Doherty Aidan J; Stewart Paul M; Arlt Wiebke
Differential inhibition of CYP17A1 and CYP21A2 activities by the P450 oxidoreductase mutant A287P.
Molecular endocrinology (Baltimore, Md.) 2007;21(8):1958-68.
2007: Tomlinson Jeremy W; Sherlock Mark; Hughes Beverley; Hughes Susan V; Kilvington Fiona; Bartlett William; Courtney Rachel; Rejto Paul; Carley William; Stewart Paul M
Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 activity in vivo limits glucocorticoid exposure to human adipose tissue and decreases lipolysis.
The Journal of clinical endocrinology and metabolism 2007;92(3):857-64.
2007: Bujalska Iwona J; Durrani Omar M; Abbott Joseph; Onyimba Claire U; Khosla Pamela; Moosavi Areeb H; Reuser Tristan T Q; Stewart Paul M; Tomlinson Jeremy W; Walker Elizabeth A; Rauz Saaeha
Characterisation of 11beta-hydroxysteroid dehydrogenase 1 in human orbital adipose tissue: a comparison with subcutaneous and omental fat.
The Journal of endocrinology 2007;192(2):279-88.
2006: Bujalska I J; Quinkler M; Tomlinson J W; Montague C T; Smith D M; Stewart P M
Expression profiling of 11beta-hydroxysteroid dehydrogenase type-1 and glucocorticoid-target genes in subcutaneous and omental human preadipocytes.
Journal of molecular endocrinology 2006;37(2):327-40.
2006: Quinkler Marcus; Bujalska Iwona J; Tomlinson Jeremy W; Smith Dave M; Stewart Paul M
Depot-specific prostaglandin synthesis in human adipose tissue: a novel possible mechanism of adipogenesis.
Gene 2006;380(2):137-43.
2006: Hammer Fabian; Stewart Paul M
Cortisol metabolism in hypertension.
Best practice & research. Clinical endocrinology & metabolism 2006;20(3):337-53.
2006: Onyimba Claire U; Vijapurapu Neelima; Curnow S John; Khosla Pamela; Stewart Paul M; Murray Philip I; Walker Elizabeth A; Rauz Saaeha
Characterisation of the prereceptor regulation of glucocorticoids in the anterior segment of the rabbit eye.
The Journal of endocrinology 2006;190(2):483-93.
2006: Draper Nicole; Powell Brenda L; Franks Steve; Conway Gerard S; Stewart Paul M; McCarthy Mark I
Variants implicated in cortisone reductase deficiency do not contribute to susceptibility to common forms of polycystic ovary syndrome.
Clinical endocrinology 2006;65(1):64-70.
2006: Arlt Wiebke; Hammer Fabian; Sanning Petra; Butcher Stephen K; Lord Janet M; Allolio Bruno; Annane Djillali; Stewart Paul M
Dissociation of serum dehydroepiandrosterone and dehydroepiandrosterone sulfate in septic shock.
The Journal of clinical endocrinology and metabolism 2006;91(7):2548-54.
2006: Banwell Claire M; MacCartney Donia P; Guy Michelle; Miles Alice E; Uskokovic Milan R; Mansi Janine; Stewart Paul M; O'Neill Laura P; Turner Bryan M; Colston Kay W; Campbell Moray J
Altered nuclear receptor corepressor expression attenuates vitamin D receptor signaling in breast cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(7 Pt 1):2004-13.
2006: Jenkins P J; Bates P; Carson M N; Stewart P M; Wass J A H
Conventional pituitary irradiation is effective in lowering serum growth hormone and insulin-like growth factor-I in patients with acromegaly.
The Journal of clinical endocrinology and metabolism 2006;91(4):1239-45.
2006: Lavery Gareth G; Walker Elizabeth A; Draper Nicole; Jeyasuria Pancharatnam; Marcos Josep; Shackleton Cedric H L; Parker Keith L; White Perrin C; Stewart Paul M
Hexose-6-phosphate dehydrogenase knock-out mice lack 11 beta-hydroxysteroid dehydrogenase type 1-mediated glucocorticoid generation.
The Journal of biological chemistry 2006;281(10):6546-51.
2006: Agha Amar; Tomlinson Jeremy W; Clark Penelope M; Holder Geoff; Stewart Paul M
The long-term predictive accuracy of the short synacthen (corticotropin) stimulation test for assessment of the hypothalamic-pituitary-adrenal axis.
The Journal of clinical endocrinology and metabolism 2006;91(1):43-7.
2006: Towsend Kelly; Trevino Victor; Falciani Francesco; Stewart Paul M; Hewison Martin; Campbell Moray J
Identification of VDR-responsive gene signatures in breast cancer cells.
Oncology 2006;71(1-2):111-23.
2006: Wagenmakers Anton J M; van Riel Natal A W; Frenneaux Michael P; Stewart Paul M
Integration of the metabolic and cardiovascular effects of exercise.
Essays in biochemistry 2006;42():193-210.
2006: Hardy Rowan S; Filer Andrew; Cooper Mark S; Parsonage Greg; Raza Karim; Hardie Debbie L; Rabbitt Elizabeth H; Stewart Paul M; Buckley Christopher D; Hewison Martin
Differential expression, function and response to inflammatory stimuli of 11beta-hydroxysteroid dehydrogenase type 1 in human fibroblasts: a mechanism for tissue-specific regulation of inflammation.
Arthritis research & therapy 2006;8(4):R108.
2005: Tomlinson Jeremy W; Stewart Paul M
Mechanisms of disease: Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome.
Nature clinical practice. Endocrinology & metabolism 2005;1(2):92-9.
2005: Hammer Fabian; Drescher Daniel G; Schneider Susanne B; Quinkler Marcus; Stewart Paul M; Allolio Bruno; Arlt Wiebke
Sex steroid metabolism in human peripheral blood mononuclear cells changes with aging.
The Journal of clinical endocrinology and metabolism 2005;90(11):6283-9.
2005: Quinkler Marcus; Bujalska Iwona J; Kaur Kirren; Onyimba Claire U; Buhner Sabine; Allolio Bruno; Hughes Susan V; Hewison Martin; Stewart Paul M
Androgen receptor-mediated regulation of the alpha-subunit of the epithelial sodium channel in human kidney.
Hypertension 2005;46(4):787-98.
2005: Quinkler Marcus; Zehnder Daniel; Eardley Kevin S; Lepenies Julia; Howie Alexander J; Hughes Susan V; Cockwell Paul; Hewison Martin; Stewart Paul M
Increased expression of mineralocorticoid effector mechanisms in kidney biopsies of patients with heavy proteinuria.
Circulation 2005;112(10):1435-43.
2005: Bassett Mary H; Mayhew Bobbie; Rehman Khurram; White Perrin C; Mantero Franco; Arnaldi Giorgio; Stewart Paul M; Bujalska Iwona; Rainey William E
Expression profiles for steroidogenic enzymes in adrenocortical disease.
The Journal of clinical endocrinology and metabolism 2005;90(9):5446-55.
2005: Mariniello Barbara; Ronconi Vanessa; Sardu Cipriana; Pagliericcio Antonella; Galletti Ferruccio; Strazzullo Pasquale; Palermo Mario; Boscaro Marco; Stewart Paul M; Mantero Franco; Giacchetti Gilberta
Analysis of the 11beta-hydroxysteroid dehydrogenase type 2 gene (HSD11B2) in human essential hypertension.
American journal of hypertension 2005;18(8):1091-8.
2005: Ayuk John; Sheppard Michael C; Bates Andrew S; Stewart Paul M
Letter re: Monitoring the response to treatment in acromegaly.
The Journal of clinical endocrinology and metabolism 2005;90(8):4980.
2005: Draper Nicole; Stewart Paul M
11beta-hydroxysteroid dehydrogenase and the pre-receptor regulation of corticosteroid hormone action.
The Journal of endocrinology 2005;186(2):251-71.
2005: Quinkler Marcus; Zehnder Daniel; Lepenies Julia; Petrelli Massimiliano D; Moore Jasbir S; Hughes Susan V; Cockwell Paul; Hewison Martin; Stewart Paul M
Expression of renal 11beta-hydroxysteroid dehydrogenase type 2 is decreased in patients with impaired renal function.
European journal of endocrinology / European Federation of Endocrine Societies 2005;153(2):291-9.
2005: Bujalska Iwona J; Draper Nicole; Michailidou Zoi; Tomlinson Jeremy W; White Perrin C; Chapman Karen E; Walker Elizabeth A; Stewart Paul M
Hexose-6-phosphate dehydrogenase confers oxo-reductase activity upon 11 beta-hydroxysteroid dehydrogenase type 1.
Journal of molecular endocrinology 2005;34(3):675-84.
2005: Cooper Mark S; Syddall Holly E; Fall Caroline H D; Wood Peter J; Stewart Paul M; Cooper Cyrus; Dennison Elaine M
Circulating cortisone levels are associated with biochemical markers of bone formation and lumbar spine BMD: the Hertfordshire Cohort Study.
Clinical endocrinology 2005;62(6):692-7.
2005: Arlt Wiebke; Stewart Paul M
Adrenal corticosteroid biosynthesis, metabolism, and action.
Endocrinology and metabolism clinics of North America 2005;34(2):293-313, viii.
2005: Hewitt Kylie N; Walker Elizabeth A; Stewart Paul M
Minireview: hexose-6-phosphate dehydrogenase and redox control of 11{beta}-hydroxysteroid dehydrogenase type 1 activity.
Endocrinology 2005;146(6):2539-43.
2005: Hammer Fabian; Subtil Sandra; Lux Philipp; Maser-Gluth Christiane; Stewart Paul M; Allolio Bruno; Arlt Wiebke
No evidence for hepatic conversion of dehydroepiandrosterone (DHEA) sulfate to DHEA: in vivo and in vitro studies.
The Journal of clinical endocrinology and metabolism 2005;90(6):3600-5.
2005: Townsend Kelly; Banwell Claire M; Guy Michelle; Colston Kay W; Mansi Janine L; Stewart Paul M; Campbell Moray J; Hewison Martin
Autocrine metabolism of vitamin D in normal and malignant breast tissue.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(9):3579-86.
2005: Stewart Paul M
Tissue-specific Cushing's syndrome uncovers a new target in treating the metabolic syndrome--11beta-hydroxysteroid dehydrogenase type 1.
Clinical medicine (London, England) 2005;5(2):142-6.
2005: Cooper Mark S; Stewart Paul M
Diagnosis and treatment of ACTH deficiency.
Reviews in endocrine & metabolic disorders 2005;6(1):47-54.
2004: Wudy Stefan A; Hartmann Michaela F; Draper Nicole; Stewart Paul M; Arlt Wiebke
A male twin infant with skull deformity and elevated neonatal 17-hydroxyprogesterone: a prismatic case of P450 oxidoreductase deficiency.
Endocrine research 2004;30(4):957-64.
2004: Quinkler Marcus; Sinha Binayak; Tomlinson Jeremy W; Bujalska Iwona J; Stewart Paul M; Arlt Wiebke
Androgen generation in adipose tissue in women with simple obesity--a site-specific role for 17beta-hydroxysteroid dehydrogenase type 5.
The Journal of endocrinology 2004;183(2):331-42.
2004: Ayuk J; Sheppard M C; Clayton R N; Bates A S; Stewart P M
Evidence for the use of igf-I as a predictor of mortality in acromegaly is lacking.
The Journal of clinical endocrinology and metabolism 2004;89(11):5867-8; author reply 5868.
2004: Stewart Paul M
Acromegaly databases--time for European unification.
European journal of endocrinology / European Federation of Endocrine Societies 2004;151(4):431-2.
2004: Tomlinson Jeremy W; Walker Elizabeth A; Bujalska Iwona J; Draper Nicole; Lavery Gareth G; Cooper Mark S; Hewison Martin; Stewart Paul M
11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response.
Endocrine reviews 2004;25(5):831-66.
2004: Valsamakis G; Anwar A; Tomlinson J W; Shackleton C H L; McTernan P G; Chetty R; Wood P J; Banerjee A K; Holder G; Barnett A H; Stewart P M; Kumar S
11beta-hydroxysteroid dehydrogenase type 1 activity in lean and obese males with type 2 diabetes mellitus.
The Journal of clinical endocrinology and metabolism 2004;89(9):4755-61.
2004: Khanim Farhat L; Gommersall Lyndon M; Wood Victoria H J; Smith Kirsty L; Montalvo Leire; O'Neill Laura P; Xu Yue; Peehl Donna M; Stewart Paul M; Turner Bryan M; Campbell Moray J
Altered SMRT levels disrupt vitamin D3 receptor signalling in prostate cancer cells.
Oncogene 2004;23(40):6712-25.
2004: Arlt Wiebke; Walker Elizabeth A; Draper Nicole; Ivison Hannah E; Ride Jon P; Hammer Fabian; Chalder Susan M; Borucka-Mankiewicz Maria; Hauffa Berthold P; Malunowicz Ewa M; Stewart Paul M; Shackleton Cedric H L
Congenital adrenal hyperplasia caused by mutant P450 oxidoreductase and human androgen synthesis: analytical study.
Lancet 2004;363(9427):2128-35.
2004: Tomlinson Jeremy W; Moore Jasbir S; Clark Penny M S; Holder Geoff; Shakespeare Lynette; Stewart Paul M
Weight loss increases 11beta-hydroxysteroid dehydrogenase type 1 expression in human adipose tissue.
The Journal of clinical endocrinology and metabolism 2004;89(6):2711-6.
2004: Ayuk J; Clayton R N; Holder G; Sheppard M C; Stewart P M; Bates A S
Growth hormone and pituitary radiotherapy, but not serum insulin-like growth factor-I concentrations, predict excess mortality in patients with acromegaly.
The Journal of clinical endocrinology and metabolism 2004;89(4):1613-7.
2004: Quinkler M; Bappal B; Draper N; Atterbury A J; Lavery G G; Walker E A; DeSilva V; Taylor N F; Hala S; Rajendra N; Stewart P M
Molecular basis for the apparent mineralocorticoid excess syndrome in the Oman population.
Molecular and cellular endocrinology 2004;217(1-2):143-9.
2004: Ayuk John; Stewart Susan E; Stewart Paul M; Sheppard Michael C;
Efficacy of Sandostatin LAR (long-acting somatostatin analogue) is similar in patients with untreated acromegaly and in those previously treated with surgery and/or radiotherapy.
Clinical endocrinology 2004;60(3):375-81.
2004: Tomlinson J W; Stewart P M
"Cushing's disease of the omentum"--fact or fiction?
Journal of endocrinological investigation 2004;27(2):171-4.
2003: Driver P M; Rauz S; Walker E A; Hewison M; Kilby M D; Stewart P M
Characterization of human trophoblast as a mineralocorticoid target tissue.
Molecular human reproduction 2003;9(12):793-8.
2003: Walker Elizabeth A; Stewart Paul M
11beta-hydroxysteroid dehydrogenase: unexpected connections.
Trends in endocrinology and metabolism: TEM 2003;14(7):334-9.
2003: Stewart Paul M
Tissue-specific Cushing's syndrome, 11beta-hydroxysteroid dehydrogenases and the redefinition of corticosteroid hormone action.
European journal of endocrinology / European Federation of Endocrine Societies 2003;149(3):163-8.
2003: Cooper Mark S; Blumsohn Aubrey; Goddard Philippa E; Bartlett William A; Shackleton Cedric H; Eastell Richard; Hewison Martin; Stewart Paul M
11beta-hydroxysteroid dehydrogenase type 1 activity predicts the effects of glucocorticoids on bone.
The Journal of clinical endocrinology and metabolism 2003;88(8):3874-7.
2003: Lavery Gareth G; Ronconi Vanessa; Draper Nicole; Rabbitt Elizabeth H; Lyons Val; Chapman Karen E; Walker Elizabeth A; McTernan Claire L; Giacchetti Gilberta; Mantero Franco; Seckl Jonathan R; Edwards Christopher R W; Connell John M C; Hewison Martin; Stewart Paul M
Late-onset apparent mineralocorticoid excess caused by novel compound heterozygous mutations in the HSD11B2 gene.
Hypertension 2003;42(2):123-9.
2003: Draper Nicole; Walker Elizabeth A; Bujalska Iwona J; Tomlinson Jeremy W; Chalder Susan M; Arlt Wiebke; Lavery Gareth G; Bedendo Oliver; Ray David W; Laing Ian; Malunowicz Ewa; White Perrin C; Hewison Martin; Mason Philip J; Connell John M; Shackleton Cedric H L; Stewart Paul M
Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency.
Nature genetics 2003;34(4):434-9.
2003: Rauz S; Cheung C M G; Wood P J; Coca-Prados M; Walker E A; Murray P I; Stewart P M
Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 lowers intraocular pressure in patients with ocular hypertension.
QJM : monthly journal of the Association of Physicians 2003;96(7):481-90.
2003: Rauz Saaeha; Walker Elizabeth A; Murray Philip I; Stewart Paul M
Expression and distribution of the serum and glucocorticoid regulated kinase and the epithelial sodium channel subunits in the human cornea.
Experimental eye research 2003;77(1):101-8.
2003: Rabbitt E H; Gittoes N J L; Stewart P M; Hewison M
11beta-hydroxysteroid dehydrogenases, cell proliferation and malignancy.
The Journal of steroid biochemistry and molecular biology 2003;85(2-5):415-21.
2003: Quinkler Marcus; Stewart Paul M
Hypertension and the cortisol-cortisone shuttle.
The Journal of clinical endocrinology and metabolism 2003;88(6):2384-92.
2003: Tomlinson Jeremy W; Crabtree Nicola; Clark Penny M S; Holder Geoff; Toogood Andrew A; Shackleton Cedric H L; Stewart Paul M
Low-dose growth hormone inhibits 11 beta-hydroxysteroid dehydrogenase type 1 but has no effect upon fat mass in patients with simple obesity.
The Journal of clinical endocrinology and metabolism 2003;88(5):2113-8.
2003: Stewart Paul M
Pegvisomant: an advance in clinical efficacy in acromegaly.
European journal of endocrinology / European Federation of Endocrine Societies 2003;148 Suppl 2():S27-32.
2003: Rauz Saaeha; Walker Elizabeth A; Hughes Susan V; Coca-Prados Miguel; Hewison Martin; Murray Philip I; Stewart Paul M
Serum- and glucocorticoid-regulated kinase isoform-1 and epithelial sodium channel subunits in human ocular ciliary epithelium.
Investigative ophthalmology & visual science 2003;44(4):1643-51.
2003: Rabbitt E H; Ayuk J; Boelaert K; Sheppard M C; Hewison M; Stewart P M; Gittoes N J L
Abnormal expression of 11 beta-hydroxysteroid dehydrogenase type 2 in human pituitary adenomas: a prereceptor determinant of pituitary cell proliferation.
Oncogene 2003;22(11):1663-7.
2003: Cooper Mark S; Stewart Paul M
Corticosteroid insufficiency in acutely ill patients.
The New England journal of medicine 2003;348(8):727-34.
2003: Banwell Claire M; Singh Rena; Stewart Paul M; Uskokovic Milan R; Campbell Moray J
Antiproliferative signalling by 1,25(OH)2D3 in prostate and breast cancer is suppressed by a mechanism involving histone deacetylation.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 2003;164():83-98.
2002: Tomlinson J W; Sinha B; Bujalska I; Hewison M; Stewart P M
Expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue is not increased in human obesity.
The Journal of clinical endocrinology and metabolism 2002;87(12):5630-5.
2002: Tomlinson J W; Stewart P M
The functional consequences of 11beta-hydroxysteroid dehydrogenase expression in adipose tissue.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2002;34(11-12):746-51.
2002: Bujalska Iwona J; Walker Elizabeth A; Tomlinson Jeremy W; Hewison Martin; Stewart Paul M
11Beta-hydroxysteroid dehydrogenase type 1 in differentiating omental human preadipocytes: from de-activation to generation of cortisol.
Endocrine research 2002;28(4):449-61.
2002: Draper N; Echwald S M; Lavery G G; Walker E A; Fraser R; Davies E; Sørensen T I A; Astrup A; Adamski J; Hewison M; Connell J M; Pedersen O; Stewart P M
Association studies between microsatellite markers within the gene encoding human 11beta-hydroxysteroid dehydrogenase type 1 and body mass index, waist to hip ratio, and glucocorticoid metabolism.
The Journal of clinical endocrinology and metabolism 2002;87(11):4984-90.
2002: Ayuk John; Stewart Susan E; Stewart Paul M; Sheppard Michael C
Long-term safety and efficacy of depot long-acting somatostatin analogs for the treatment of acromegaly.
The Journal of clinical endocrinology and metabolism 2002;87(9):4142-6.
2002: Zehnder Daniel; Evans Katie N; Kilby Mark D; Bulmer Judith N; Innes Barbara A; Stewart Paul M; Hewison Martin
The ontogeny of 25-hydroxyvitamin D(3) 1alpha-hydroxylase expression in human placenta and decidua.
The American journal of pathology 2002;161(1):105-14.
2002: Cooper Mark S; Rabbitt Elizabeth H; Goddard Philippa E; Bartlett William A; Hewison Martin; Stewart Paul M
Osteoblastic 11beta-hydroxysteroid dehydrogenase type 1 activity increases with age and glucocorticoid exposure.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002;17(6):979-86.
2002: Lavery Gareth G; McTernan Claire L; Bain Stephen C; Chowdhury Tahseen A; Hewison Martin; Stewart Paul M
Association studies between the HSD11B2 gene (encoding human 11beta-hydroxysteroid dehydrogenase type 2), type 1 diabetes mellitus and diabetic nephropathy.
European journal of endocrinology / European Federation of Endocrine Societies 2002;146(4):553-8.
2002: Kirkman-Brown J C; Lefièvre L; Bray C; Stewart P M; Barratt C L R; Publicover S J
Inhibitors of receptor tyrosine kinases do not suppress progesterone-induced [Ca2+]i signalling in human spermatozoa.
Molecular human reproduction 2002;8(4):326-32.
2002: McTernan Philip G; Anderson Leah A; Anwar Aresh J; Eggo Margaret C; Crocker John; Barnett Anthony H; Stewart Paul M; Kumar Sudhesh
Glucocorticoid regulation of p450 aromatase activity in human adipose tissue: gender and site differences.
The Journal of clinical endocrinology and metabolism 2002;87(3):1327-36.
2002: Bujalska Iwona J; Walker Elizabeth A; Hewison Martin; Stewart Paul M
A switch in dehydrogenase to reductase activity of 11 beta-hydroxysteroid dehydrogenase type 1 upon differentiation of human omental adipose stromal cells.
The Journal of clinical endocrinology and metabolism 2002;87(3):1205-10.
2002: Zehnder Daniel; Bland Rosemary; Chana Ravinder S; Wheeler David C; Howie Alexander J; Williams Mary C; Stewart Paul M; Hewison Martin
Synthesis of 1,25-dihydroxyvitamin D(3) by human endothelial cells is regulated by inflammatory cytokines: a novel autocrine determinant of vascular cell adhesion.
Journal of the American Society of Nephrology : JASN 2002;13(3):621-9.
2002: Tomlinson Jeremy W; Draper Nicole; Mackie Joanna; Johnson Alan P; Holder Geoff; Wood Peter; Stewart Paul M
Absence of Cushingoid phenotype in a patient with Cushing's disease due to defective cortisone to cortisol conversion.
The Journal of clinical endocrinology and metabolism 2002;87(1):57-62.
2002: Rabbitt Elizabeth H; Lavery Gareth G; Walker Elizabeth A; Cooper Mark S; Stewart Paul M; Hewison Martin
Prereceptor regulation of glucocorticoid action by 11beta-hydroxysteroid dehydrogenase: a novel determinant of cell proliferation.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(1):36-44.
2001: McTernan C L; Draper N; Nicholson H; Chalder S M; Driver P; Hewison M; Kilby M D; Stewart P M
Reduced placental 11beta-hydroxysteroid dehydrogenase type 2 mRNA levels in human pregnancies complicated by intrauterine growth restriction: an analysis of possible mechanisms.
The Journal of clinical endocrinology and metabolism 2001;86(10):4979-83.
2001: Bland R; Zehnder D; Hughes S V; Ronco P M; Stewart P M; Hewison M
Regulation of vitamin D-1alpha-hydroxylase in a human cortical collecting duct cell line.
Kidney international 2001;60(4):1277-86.
2001: White P C; Agarwal A K; Li A; Nikkila H; Pratt J H; Caulfield M; Clark A; McTernan C; Stewart P M
Possible association but no linkage of the HSD11B2 gene encoding the kidney isozyme of 11beta-hydroxysteroid dehydrogenase to hypertension in Black people.
Clinical endocrinology 2001;55(2):249-52.
2001: Rauz S; Walker E A; Shackleton C H; Hewison M; Murray P I; Stewart P M
Expression and putative role of 11 beta-hydroxysteroid dehydrogenase isozymes within the human eye.
Investigative ophthalmology & visual science 2001;42(9):2037-42.
2001: Korbonits M; Bujalska I; Shimojo M; Nobes J; Jordan S; Grossman A B; Stewart P M
Expression of 11 beta-hydroxysteroid dehydrogenase isoenzymes in the human pituitary: induction of the type 2 enzyme in corticotropinomas and other pituitary tumors.
The Journal of clinical endocrinology and metabolism 2001;86(6):2728-33.
2001: Cooper M S; Bujalska I; Rabbitt E; Walker E A; Bland R; Sheppard M C; Hewison M; Stewart P M
Modulation of 11beta-hydroxysteroid dehydrogenase isozymes by proinflammatory cytokines in osteoblasts: an autocrine switch from glucocorticoid inactivation to activation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2001;16(6):1037-44.
2001: Walker E A; Clark A M; Hewison M; Ride J P; Stewart P M
Functional expression, characterization, and purification of the catalytic domain of human 11-beta -hydroxysteroid dehydrogenase type 1.
The Journal of biological chemistry 2001;276(24):21343-50.
2001: Tomlinson J W; Moore J; Cooper M S; Bujalska I; Shahmanesh M; Burt C; Strain A; Hewison M; Stewart P M
Regulation of expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue: tissue-specific induction by cytokines.
Endocrinology 2001;142(5):1982-9.
2001: Driver P M; Kilby M D; Bujalska I; Walker E A; Hewison M; Stewart P M
Expression of 11 beta-hydroxysteroid dehydrogenase isozymes and corticosteroid hormone receptors in primary cultures of human trophoblast and placental bed biopsies.
Molecular human reproduction 2001;7(4):357-63.
2001: Tomlinson J W; Stewart P M
Cortisol metabolism and the role of 11beta-hydroxysteroid dehydrogenase.
Best practice & research. Clinical endocrinology & metabolism 2001;15(1):61-78.
2001: Tomlinson J W; Holden N; Hills R K; Wheatley K; Clayton R N; Bates A S; Sheppard M C; Stewart P M
Association between premature mortality and hypopituitarism. West Midlands Prospective Hypopituitary Study Group.
Lancet 2001;357(9254):425-31.
2001: Zehnder D; Bland R; Williams M C; McNinch R W; Howie A J; Stewart P M; Hewison M
Extrarenal expression of 25-hydroxyvitamin d(3)-1 alpha-hydroxylase.
The Journal of clinical endocrinology and metabolism 2001;86(2):888-94.
2001: English M A; Stewart P M; Hewison M
Estrogen metabolism and malignancy: analysis of the expression and function of 17beta-hydroxysteroid dehydrogenases in colonic cancer.
Molecular and cellular endocrinology 2001;171(1-2):53-60.
2001: Stewart P M; Toogood A A; Tomlinson J W
Growth hormone, insulin-like growth factor-I and the cortisol-cortisone shuttle.
Hormone research 2001;56 Suppl 1():1-6.
2001: Eyre L J; Rabbitt E H; Bland R; Hughes S V; Cooper M S; Sheppard M C; Stewart P M; Hewison M
Expression of 11 beta-hydroxysteroid dehydrogenase in rat osteoblastic cells: pre-receptor regulation of glucocorticoid responses in bone.
Journal of cellular biochemistry 2001;81(3):453-62.
2000: White P C; Agarwal A K; Nunez B S; Giacchetti G; Mantero F; Stewart P M
Genotype-phenotype correlations of mutations and polymorphisms in HSD11B2, the gene encoding the kidney isozyme of 11beta-hydroxysteroid dehydrogenase.
Endocrine research 2000;26(4):771-80.
2000: Tomlinson J W; Bujalska I; Stewart P M; Cooper M S
The role of 11 beta-hydroxysteroid dehydrogenase in central obesity and osteoporosis.
Endocrine research 2000;26(4):711-22.
2000: Hewison M; Zehnder D; Bland R; Stewart P M
1alpha-Hydroxylase and the action of vitamin D.
Journal of molecular endocrinology 2000;25(2):141-8.
2000: Cooper M S; Walker E A; Bland R; Fraser W D; Hewison M; Stewart P M
Expression and functional consequences of 11beta-hydroxysteroid dehydrogenase activity in human bone.
Bone 2000;27(3):375-81.
2000: Stewart P M
Dexamethasone-suppressible hypertension.
Lancet 2000;356(9231):697-9.
2000: Agarwal A K; Giacchetti G; Lavery G; Nikkila H; Palermo M; Ricketts M; McTernan C; Bianchi G; Manunta P; Strazzullo P; Mantero F; White P C; Stewart P M
CA-Repeat polymorphism in intron 1 of HSD11B2 : effects on gene expression and salt sensitivity.
Hypertension 2000;36(2):187-94.
2000: English M A; Hughes S V; Kane K F; Langman M J; Stewart P M; Hewison M
Oestrogen inactivation in the colon: analysis of the expression and regulation of 17beta-hydroxysteroid dehydrogenase isozymes in normal colon and colonic cancer.
British journal of cancer 2000;83(4):550-8.
2000: McTernan P G; Anwar A; Eggo M C; Barnett A H; Stewart P M; Kumar S
Gender differences in the regulation of P450 aromatase expression and activity in human adipose tissue.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2000;24(7):875-81.
2000: Kirkman-Brown J C; Bray C; Stewart P M; Barratt C L; Publicover S J
Biphasic elevation of [Ca(2+)](i) in individual human spermatozoa exposed to progesterone.
Developmental biology 2000;222(2):326-35.
2000: Stewart P M
Current therapy for acromegaly.
Trends in endocrinology and metabolism: TEM 2000;11(4):128-32.
1999: Zehnder D; Bland R; Walker E A; Bradwell A R; Howie A J; Hewison M; Stewart P M
Expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in the human kidney.
Journal of the American Society of Nephrology : JASN 1999;10(12):2465-73.
1999: Gittoes N J; Sheppard M C; Johnson A P; Stewart P M
Outcome of surgery for acromegaly--the experience of a dedicated pituitary surgeon.
QJM : monthly journal of the Association of Physicians 1999;92(12):741-5.
1999: Moore J S; Monson J P; Kaltsas G; Putignano P; Wood P J; Sheppard M C; Besser G M; Taylor N F; Stewart P M
Modulation of 11beta-hydroxysteroid dehydrogenase isozymes by growth hormone and insulin-like growth factor: in vivo and in vitro studies.
The Journal of clinical endocrinology and metabolism 1999;84(11):4172-7.
1999: Cooper M S; Hewison M; Stewart P M
Glucocorticoid activity, inactivity and the osteoblast.
The Journal of endocrinology 1999;163(2):159-64.
1999: Stewart P M; James R A
The future of somatostatin analogue therapy.
Baillière's best practice & research. Clinical endocrinology & metabolism 1999;13(3):409-18.
1999: Stewart P M; Clark P
The short Synacthen test: is less best?
Clinical endocrinology 1999;51(2):151-2.
1999: Bujalska I J; Kumar S; Hewison M; Stewart P M
Differentiation of adipose stromal cells: the roles of glucocorticoids and 11beta-hydroxysteroid dehydrogenase.
Endocrinology 1999;140(7):3188-96.
1999: English M A; Kane K F; Cruickshank N; Langman M J; Stewart P M; Hewison M
Loss of estrogen inactivation in colonic cancer.
The Journal of clinical endocrinology and metabolism 1999;84(6):2080-5.
1999: Ricketts M L; Stewart P M
Regulation of 11beta-hydroxysteroid dehydrogenase type 2 by diuretics and the renin-angiotensin-aldosterone axis.
Clinical science (London, England : 1979) 1999;96(6):669-75.
1999: Bland R; Worker C A; Noble B S; Eyre L J; Bujalska I J; Sheppard M C; Stewart P M; Hewison M
Characterization of 11beta-hydroxysteroid dehydrogenase activity and corticosteroid receptor expression in human osteosarcoma cell lines.
The Journal of endocrinology 1999;161(3):455-64.
1999: Bland R; Walker E A; Hughes S V; Stewart P M; Hewison M
Constitutive expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in a transformed human proximal tubule cell line: evidence for direct regulation of vitamin D metabolism by calcium.
Endocrinology 1999;140(5):2027-34.
1999: Stewart P M; Sheppard M C
Mortality and hypopituitarism.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 1999;9 Suppl A():15-9.
1999: Stewart P M
Cortisol as a mineralocorticoid in human disease.
The Journal of steroid biochemistry and molecular biology 1999;69(1-6):403-8.
1999: Stewart P M
Mineralocorticoid hypertension.
Lancet 1999;353(9161):1341-7.
1999: Bates A S; Bullivant B; Sheppard M C; Stewart P M
Life expectancy following surgery for pituitary tumours.
Clinical endocrinology 1999;50(3):315-9.
1999: Stewart P M; Stewart S E; Clark P M; Sheppard M C
Clinical and biochemical response following withdrawal of a long-acting, depot injection form of octreotide (Sandostatin-LAR).
Clinical endocrinology 1999;50(3):295-9.
1999: Stewart P M; Boulton A; Kumar S; Clark P M; Shackleton C H
Cortisol metabolism in human obesity: impaired cortisone-->cortisol conversion in subjects with central adiposity.
The Journal of clinical endocrinology and metabolism 1999;84(3):1022-7.
1999: Stewart P M; Krozowski Z S
11 beta-Hydroxysteroid dehydrogenase.
Vitamins and hormones 1999;57():249-324.
1998: Condon J; Gosden C; Gardener D; Nickson P; Hewison M; Howie A J; Stewart P M
Expression of type 2 11beta-hydroxysteroid dehydrogenase and corticosteroid hormone receptors in early human fetal life.
The Journal of clinical endocrinology and metabolism 1998;83(12):4490-7.
1998: Li A; Tedde R; Krozowski Z S; Pala A; Li K X; Shackleton C H; Mantero F; Palermo M; Stewart P M
Molecular basis for hypertension in the "type II variant" of apparent mineralocorticoid excess.
American journal of human genetics 1998;63(2):370-9.
1998: Eyre L J; Bland R; Bujalska I J; Sheppard M C; Stewart P M; Hewison M
Characterization of aromatase and 17 beta-hydroxysteroid dehydrogenase expression in rat osteoblastic cells.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1998;13(6):996-1004.
1998: Trainer P J; Woods R J; Korbonits M; Popovic V; Stewart P M; Lowry P J; Grossman A B
The pathophysiology of circulating corticotropin-releasing hormone-binding protein levels in the human.
The Journal of clinical endocrinology and metabolism 1998;83(5):1611-4.
1998: Shams M; Kilby M D; Somerset D A; Howie A J; Gupta A; Wood P J; Afnan M; Stewart P M
11Beta-hydroxysteroid dehydrogenase type 2 in human pregnancy and reduced expression in intrauterine growth restriction.
Human reproduction (Oxford, England) 1998;13(4):799-804.
1998: Ricketts M L; Verhaeg J M; Bujalska I; Howie A J; Rainey W E; Stewart P M
Immunohistochemical localization of type 1 11beta-hydroxysteroid dehydrogenase in human tissues.
The Journal of clinical endocrinology and metabolism 1998;83(4):1325-35.
1998: Gittoes N J; Bates A S; Tse W; Bullivant B; Sheppard M C; Clayton R N; Stewart P M
Radiotherapy for non-function pituitary tumours.
Clinical endocrinology 1998;48(3):331-7.
1998: Davies P H; Stewart S E; Lancranjan L; Sheppard M C; Stewart P M
Long-term therapy with long-acting octreotide (Sandostatin-LAR) for the management of acromegaly.
Clinical endocrinology 1998;48(3):311-6.
1998: Ricketts M L; Shoesmith K J; Hewison M; Strain A; Eggo M C; Stewart P M
Regulation of 11 beta-hydroxysteroid dehydrogenase type 1 in primary cultures of rat and human hepatocytes.
The Journal of endocrinology 1998;156(1):159-68.
1998: Petrelli M; Stewart P M
Monogenic forms of mineralocorticoid hypertension: insights into the pathogenesis of 'essential' hypertension?
Journal of human hypertension 1998;12(1):7-12.
1997: Li A; Li K X; Marui S; Krozowski Z S; Batista M C; Whorwood C B; Arnhold I J; Shackleton C H; Mendonca B B; Stewart P M
Apparent mineralocorticoid excess in a Brazilian kindred: hypertension in the heterozygote state.
Journal of hypertension 1997;15(12 Pt 1):1397-402.
1997: Hughes S V; Robinson E; Bland R; Lewis H M; Stewart P M; Hewison M
1,25-dihydroxyvitamin D3 regulates estrogen metabolism in cultured keratinocytes.
Endocrinology 1997;138(9):3711-8.
1997: Petrelli M D; Lim-Tio S S; Condon J; Hewison M; Stewart P M
Differential expression of nuclear 11beta-hydroxysteroid dehydrogenase type 2 in mineralocorticoid receptor positive and negative tissues.
Endocrinology 1997;138(7):3077-80.
1997: Bujalska I J; Kumar S; Stewart P M
Does central obesity reflect "Cushing's disease of the omentum"?
Lancet 1997;349(9060):1210-3.
1997: Condon J; Ricketts M L; Whorwood C B; Stewart P M
Ontogeny and sexual dimorphic expression of mouse type 2 11beta-hydroxysteroid dehydrogenase.
Molecular and cellular endocrinology 1997;127(2):121-8.
1997: Shimojo M; Ricketts M L; Petrelli M D; Moradi P; Johnson G D; Bradwell A R; Hewison M; Howie A J; Stewart P M
Immunodetection of 11 beta-hydroxysteroid dehydrogenase type 2 in human mineralocorticoid target tissues: evidence for nuclear localization.
Endocrinology 1997;138(3):1305-11.
1997: Bujalska I; Shimojo M; Howie A; Stewart P M
Human 11 beta-hydroxysteroid dehydrogenase: studies on the stably transfected isoforms and localization of the type 2 isozyme within renal tissue.
Steroids 1997;62(1):77-82.
1996: Shimojo M; Condon J; Whorwood C B; Stewart P M
Adrenal 11 beta-hydroxysteroid dehydrogenase.
Endocrine research 1996;22(4):771-80.
1996: Shimojo M; Whorwood C B; Stewart P M
11 beta-Hydroxysteroid dehydrogenase in the rat adrenal.
Journal of molecular endocrinology 1996;17(2):121-30.
1996: Sheppard M C; Stewart P M
Treatment options for acromegaly.
Metabolism: clinical and experimental 1996;45(8 Suppl 1):63-4.
1996: Stewart P M
11 beta-Hydroxysteroid dehydrogenase: implications for clinical medicine.
Clinical endocrinology 1996;44(5):493-9.
1996: Stewart P M; Krozowski Z S; Gupta A; Milford D V; Howie A J; Sheppard M C; Whorwood C B
Hypertension in the syndrome of apparent mineralocorticoid excess due to mutation of the 11 beta-hydroxysteroid dehydrogenase type 2 gene.
Lancet 1996;347(8994):88-91.
1995: Stewart P M; Whorwood C B; Mason J I
Type 2 11 beta-hydroxysteroid dehydrogenase in foetal and adult life.
The Journal of steroid biochemistry and molecular biology 1995;55(5-6):465-71.
1995: Stewart P M; Walker B R; Holder G; O'Halloran D; Shackleton C H
11 beta-Hydroxysteroid dehydrogenase activity in Cushing's syndrome: explaining the mineralocorticoid excess state of the ectopic adrenocorticotropin syndrome.
The Journal of clinical endocrinology and metabolism 1995;80(12):3617-20.
1995: Dunne F P; Elliot P; Gammage M D; Stallard T; Ryan T; Sheppard M C; Stewart P M
Cardiovascular function and glucocorticoid replacement in patients with hypopituitarism.
Clinical endocrinology 1995;43(5):623-9.
1995: Jenkins D; O'Brien I; Johnson A; Shakespear R; Sheppard M C; Stewart P M
The Birmingham pituitary database: auditing the outcome of the treatment of acromegaly.
Clinical endocrinology 1995;43(5):517-22.
1995: Stewart P M; Kane K F; Stewart S E; Lancranjan I; Sheppard M C
Depot long-acting somatostatin analog (Sandostatin-LAR) is an effective treatment for acromegaly.
The Journal of clinical endocrinology and metabolism 1995;80(11):3267-72.
1995: Whorwood C B; Stewart P M
Transcriptional regulation of Na/K-ATPase by corticosteroids, glycyrrhetinic acid and second messenger pathways in rat kidney epithelial cells.
Journal of molecular endocrinology 1995;15(1):93-103.
1995: Shimojo M; Stewart P M
Apparent mineralocorticoid excess syndromes.
Journal of endocrinological investigation 1995;18(7):518-32.
1995: Kane K F; Emery P; Sheppard M C; Stewart P M
Assessing the hypothalamo-pituitary-adrenal axis in patients on long-term glucocorticoid therapy: the short synacthen versus the insulin tolerance test.
QJM : monthly journal of the Association of Physicians 1995;88(4):263-7.
1995: Whorwood C B; Mason J I; Ricketts M L; Howie A J; Stewart P M
Detection of human 11 beta-hydroxysteroid dehydrogenase isoforms using reverse-transcriptase-polymerase chain reaction and localization of the type 2 isoform to renal collecting ducts.
Molecular and cellular endocrinology 1995;110(1-2):R7-12.
1995: Stewart P M; Mason J I
Cortisol to cortisone: glucocorticoid to mineralocorticoid.
Steroids 1995;60(1):143-6.
1994: Whorwood C B; Ricketts M L; Stewart P M
Epithelial cell localization of type 2 11 beta-hydroxysteroid dehydrogenase in rat and human colon.
Endocrinology 1994;135(6):2533-41.
1994: Chaidarun S S; Eggo M C; Stewart P M; Sheppard M C
Modulation of epidermal growth factor binding and receptor gene expression by hormones and growth factors in sheep pituitary cells.
The Journal of endocrinology 1994;143(3):489-96.
1994: Chaidarun S S; Eggo M C; Sheppard M C; Stewart P M
Expression of epidermal growth factor (EGF), its receptor, and related oncoprotein (erbB-2) in human pituitary tumors and response to EGF in vitro.
Endocrinology 1994;135(5):2012-21.
1994: Whorwood C B; Ricketts M L; Stewart P M
Regulation of sodium-potassium adenosine triphosphate subunit gene expression by corticosteroids and 11 beta-hydroxysteroid dehydrogenase activity.
Endocrinology 1994;135(3):901-10.
1994: Stewart P M; Krozowski Z
Lessons from Appenberg: 11 beta-hydroxysteroid dehydrogenase 1B or 2?
The Journal of endocrinology 1994;141(2):191-3.
1994: Stewart P M
11 beta-Hydroxysteroid dehydrogenase.
Baillière's clinical endocrinology and metabolism 1994;8(2):357-78.
1994: Chaidarun S S; Eggo M C; Stewart P M; Barber P C; Sheppard M C
Role of growth factors and estrogen as modulators of growth, differentiation, and expression of gonadotropin subunit genes in primary cultured sheep pituitary cells.
Endocrinology 1994;134(2):935-44.
1994: Stewart P M; Whorwood C B
11 beta-Hydroxysteroid dehydrogenase activity and corticosteroid hormone action.
Steroids 1994;59(2):90-5.
1994: Stewart P M; Gibson S; Crosby S R; Penn R; Holder R; Ferry D; Thatcher N; Phillips P; London D R; White A
ACTH precursors characterize the ectopic ACTH syndrome.
Clinical endocrinology 1994;40(2):199-204.
1993: Stewart P M; Whorwood C B; Walker B R
Steroid hormones and hypertension: the cortisol-cortisone shuttle.
Steroids 1993;58(12):614-20.
1993: Whorwood C B; Sheppard M C; Stewart P M
Tissue specific effects of thyroid hormone on 11 beta-hydroxysteroid dehydrogenase gene expression.
The Journal of steroid biochemistry and molecular biology 1993;46(5):539-47.
1993: Whorwood C B; Sheppard M C; Stewart P M
Licorice inhibits 11 beta-hydroxysteroid dehydrogenase messenger ribonucleic acid levels and potentiates glucocorticoid hormone action.
Endocrinology 1993;132(6):2287-92.
1993: Whorwood C B; Barber P C; Gregory J; Sheppard M C; Stewart P M
11 beta-hydroxysteroid dehydrogenase and corticosteroid hormone receptors in the rat colon.
The American journal of physiology 1993;264(6 Pt 1):E951-7.
1993: Stewart P M
Reproduction and the shuttle.
Clinical endocrinology 1993;38(6):645-6.
1993: Jenkins D; Stewart P M
Advances in medical therapy for pituitary disease: treating patients with growth hormone excess and deficiency.
Journal of clinical pharmacy and therapeutics 1993;18(3):155-63.
1993: Stewart P M; Penn R; Holder R; Parton A; Ratcliffe J G; London D R
The hypothalamo-pituitary-adrenal axis across the normal menstrual cycle and in polycystic ovary syndrome.
Clinical endocrinology 1993;38(4):387-91.
1993: Stewart P M; Whorwood C B; Valentino R; Burt D; Sheppard M C; Edwards C R
11-beta-hydroxysteroid dehydrogenase activity and gene expression in the hypertensive Bianchi-Milan rat.
Journal of hypertension 1993;11(4):349-54.
1993: Stewart P M; Burra P; Shackleton C H; Sheppard M C; Elias E
11 beta-Hydroxysteroid dehydrogenase deficiency and glucocorticoid status in patients with alcoholic and non-alcoholic chronic liver disease.
The Journal of clinical endocrinology and metabolism 1993;76(3):748-51.
1992: Stewart P M; Carey M P; Graham C T; Wright A D; London D R
Growth hormone secreting pituitary carcinoma: a case report and literature review.
Clinical endocrinology 1992;37(2):189-94.
1992: Stewart P M; Venn P; Heath D A; Holder G
Cyclical Cushing's syndrome.
British journal of hospital medicine 1992;48(3-4):186-7.
1992: Stewart P M; Penn R; Gibson R; Holder R; Parton A; Ratcliffe J G; London D R
Hypothalamic abnormalities in patients with pituitary-dependent Cushing's syndrome.
Clinical endocrinology 1992;36(5):453-8.
1992: Stewart P M; Sheppard M C
Novel aspects of hormone action: intracellular ligand supply and its control by a series of tissue specific enzymes.
Molecular and cellular endocrinology 1992;83(2-3):C13-8.
1992: Whorwood C B; Franklyn J A; Sheppard M C; Stewart P M
Tissue localization of 11 beta-hydroxysteroid dehydrogenase and its relationship to the glucocorticoid receptor.
The Journal of steroid biochemistry and molecular biology 1992;41(1):21-8.
1991: Edwards C R; Stewart P M
The cortisol-cortisone shuttle and the apparent specificity of glucocorticoid and mineralocorticoid receptors.
The Journal of steroid biochemistry and molecular biology 1991;39(5B):859-65.
1991: Stewart P M; Whorwood C B; Barber P; Gregory J; Monder C; Franklyn J A; Sheppard M C
Localization of renal 11 beta-dehydrogenase by in situ hybridization: autocrine not paracrine protector of the mineralocorticoid receptor.
Endocrinology 1991;128(4):2129-35.
1990: Stewart P M; Shackleton C H; Beastall G H; Edwards C R
5 alpha-reductase activity in polycystic ovary syndrome.
Lancet 1990;335(8687):431-3.
1990: Stewart P M; Wallace A M; Atherden S M; Shearing C H; Edwards C R
Mineralocorticoid activity of carbenoxolone: contrasting effects of carbenoxolone and liquorice on 11 beta-hydroxysteroid dehydrogenase activity in man.
Clinical science (London, England : 1979) 1990;78(1):49-54.
1989: Stewart P M; McIntyre M A; Edwards C R
The endocrinopathy of POEMS syndrome.
Scottish medical journal 1989;34(5):520-2.
1989: Whitworth J A; Stewart P M; Burt D; Atherden S M; Edwards C R
The kidney is the major site of cortisone production in man.
Clinical endocrinology 1989;31(3):355-61.
1989: Monder C; Stewart P M; Lakshmi V; Valentino R; Burt D; Edwards C R
Licorice inhibits corticosteroid 11 beta-dehydrogenase of rat kidney and liver: in vivo and in vitro studies.
Endocrinology 1989;125(2):1046-53.
1989: Stewart P M; Edwards C R
The medical treatment of adrenal disease.
British journal of hospital medicine 1989;42(1):20-9.
1989: Edwards C R; Burt D; Stewart P M
The specificity of the human mineralocorticoid receptor: clinical clues to a biological conundrum.
Journal of steroid biochemistry 1989;32(1B):213-6.
1988: Edwards C R; Stewart P M; Burt D; Brett L; McIntyre M A; Sutanto W S; de Kloet E R; Monder C
Localisation of 11 beta-hydroxysteroid dehydrogenase--tissue specific protector of the mineralocorticoid receptor.
Lancet 1988;2(8618):986-9.
1988: Stewart P M; Atherden S M; Stewart S E; Whalley L; Edwards C R; Padfield P L
Lithium carbonate--a competitive aldosterone antagonist?
The British journal of psychiatry : the journal of mental science 1988;153():205-7.
1988: Stewart P M; Corrie J E; Shackleton C H; Edwards C R
Syndrome of apparent mineralocorticoid excess. A defect in the cortisol-cortisone shuttle.
The Journal of clinical investigation 1988;82(1):340-9.
1988: Stewart P M; Corrie J; Seckl J R; Edwards C R; Padfield P L
A rational approach for assessing the hypothalamo-pituitary-adrenal axis.
Lancet 1988;1(8596):1208-10.
1987: Stewart P M; Wallace A M; Valentino R; Burt D; Shackleton C H; Edwards C R
Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of age.
Lancet 1987;2(8563):821-4.
1987: Stewart P M; Grieve J; Nairn I M; Padfield P L; Edwards C R
Lithium inhibits the action of fludrocortisone on the kidney.
Clinical endocrinology 1987;27(1):63-8.

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