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Paul Stewart

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Jonathan M Hazlehurst; Maryam Nasiri; Paul M Stewart; Matthew J Armstrong; Sarah Borrows; Laura L Gathercole; Anton J M Wagenmakers; Jinglei Yu; Jeremy W Tomlinson
Glucocorticoids fail to cause insulin resistance in human subcutaneous adipose tissue in vivo.
Gareth G Lavery; Jonathan P Ride; KM Saqib; Cedric H L Shackleton; Mark Sherlock; Wiebke Arlt; Iwona J Bujalska; J De Schepper; M F Hartmann; B Hughes; J Idkowiak; Nils Krone; Elizabeth A Walker; S A Wudy; Paul M Stewart
Novel H6PDH mutations in two girls with premature adrenarche: 'apparent' and 'true' CRD can be differentiated by urinary steroid profiling.
Jonathan M Hazlehurst; Michael W O'Reilly; Ian A Rowe; Mark Sherlock; Paul M Stewart; Matthew J Armstrong; Jayne A Franklyn; Jeremy W Tomlinson
A comparative quality assessment of evidence-based clinical guidelines in endocrinology.

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2013: Jonathan M Hazlehurst; Maryam Nasiri; Paul M Stewart; Matthew J Armstrong; Sarah Borrows; Laura L Gathercole; Anton J M Wagenmakers; Jinglei Yu; Jeremy W Tomlinson
Glucocorticoids fail to cause insulin resistance in human subcutaneous adipose tissue in vivo.
The Journal of clinical endocrinology and metabolism 2013;98(4):1631-40.
2013: Gareth G Lavery; Jonathan P Ride; KM Saqib; Cedric H L Shackleton; Mark Sherlock; Wiebke Arlt; Iwona J Bujalska; J De Schepper; M F Hartmann; B Hughes; J Idkowiak; Nils Krone; Elizabeth A Walker; S A Wudy; Paul M Stewart
Novel H6PDH mutations in two girls with premature adrenarche: 'apparent' and 'true' CRD can be differentiated by urinary steroid profiling.
European journal of endocrinology / European Federation of Endocrine Societies 2013;168(2):K19-26.
2013: Jonathan M Hazlehurst; Michael W O'Reilly; Ian A Rowe; Mark Sherlock; Paul M Stewart; Matthew J Armstrong; Jayne A Franklyn; Jeremy W Tomlinson
A comparative quality assessment of evidence-based clinical guidelines in endocrinology.
Clinical endocrinology 2013;78(2):183-90.
2013: Vasileios Chortis; Martin Fassnacht; Stefanie Hahner; Beverly A Hughes; Niki Karavitaki; Rossella Libé; Massimo Mannelli; Franco Mantero; Peter Nightingale; Donna M O'Neil; Giuseppe Opocher; Emilio Porfiri; Marcus Quinkler; Petra Schneider; Cedric H L Shackleton; Mark Sherlock; Paul M Stewart; Angela E Taylor; Massimo Terzolo; Jeremy W Tomlinson; Bruno Allolio; Xavier Bertagna; Jérôme Bertherat; Felix Beuschlein; Wiebke Arlt
Mitotane therapy in adrenocortical cancer induces CYP3A4 and inhibits 5α-reductase, explaining the need for personalized glucocorticoid and androgen replacement.
The Journal of clinical endocrinology and metabolism 2013;98(1):161-71.
2012: Oliver J Wilson; Christopher S Shaw; Mark Sherlock; Paul M Stewart; Anton J M Wagenmakers
Immunofluorescent visualisation of focal adhesion kinase in human skeletal muscle and its associated microvasculature.
Histochemistry and cell biology 2012;138(4):617-26.
2012: Lianne Abrahams; Phil Guest; Beverly Hughes; Gareth G Lavery; Nina M Semjonous; Agnieszka Zielinska; Paul M Stewart
Biomarkers of hypothalamic-pituitary-adrenal axis activity in mice lacking 11β-HSD1 and H6PDH.
The Journal of endocrinology 2012;214(3):367-72.
2012: Pushpa Patel; Elizabeth Rabbitt; Paul M Stewart; Vaiyapuri Sumathi; Neil J L Gittoes; Robert Grimer; Rowan Hardy; Lars-Gunnar Kindblom; Gillian Bartle; Iwona Bujalska; Mark S Cooper
Expression of 11β-hydroxysteroid dehydrogenase enzymes in human osteosarcoma: potential role in pathogenesis and as targets for treatments.
Endocrine-related cancer 2012;19(4):589-98.
2012: Gareth G Lavery; Stuart A Morgan; Elizabeth H Rabbitt; Gary Reynolds; KM Saqib; Nina Semjonous; Mark Sherlock; Laura L Gathercole; Phillip Guest; Beverly Hughes; Jeremy W Tomlinson; Elizabeth A Walker; Agnieszka E Zielinska; Paul M Stewart
Lack of significant metabolic abnormalities in mice with liver-specific disruption of 11β-hydroxysteroid dehydrogenase type 1.
Endocrinology 2012;153(7):3236-48.
2012: Mohammad M Ahasan; Cécile Bénézech; Christopher D Buckley; Jorge H Caamaño; Andrew R Clark; Andrew Filer; Rowan Hardy; Zaki Hassan-Smith; Martin Hewison; Christopher Jones; Maria Juarez; Kirren Kaur; Gareth Lavery; Stuart A Morgan; Dominika Nanus; Elizabeth H Rabbitt; Karim Raza; Paul M Stewart; Mark S Cooper
Inflammatory regulation of glucocorticoid metabolism in mesenchymal stromal cells.
Arthritis and rheumatism 2012;64(7):2404-13.
2012: Paul M Stewart; Mark Sherlock
Mortality and pituitary disease.
Annales d'endocrinologie 2012;73(2):81-2.
2012: Zaki K Hassan-Smith; Alan P Johnson; Raoul C Reulen; Mark Sherlock; Wiebke Arlt; John Ayuk; Mark S Cooper; Andrew A Toogood; Paul M Stewart
Outcome of Cushing's disease following transsphenoidal surgery in a single center over 20 years.
The Journal of clinical endocrinology and metabolism 2012;97(4):1194-201.
2012: Nicola C Edwards; Charles J Ferro; Richard Steeds; Paul M Stewart; Colin D Chue; Jonathan N Townend
The safety and tolerability of spironolactone in patients with mild to moderate chronic kidney disease.
British journal of clinical pharmacology 2012;73(3):447-54.
2012: Adeeba Ahmed; Theresa Brady; Claire Brown; Iwona J Bujalska; Craig Doig; Elwyn Elias; Peter Guest; Stefan Hubscher; Philip N Newsome; Elizabeth Rabbitt; David H Adams; Jeremy W Tomlinson; Paul M Stewart
A switch in hepatic cortisol metabolism across the spectrum of non alcoholic fatty liver disease.
PloS one 2012;7(2):e29531.
2011: Wiebke Arlt; Xavier Bertagna; Jérôme Bertherat; Michael Biehl; Martin Fassnacht; Stefanie Hahner; Beverly A Hughes; Nils Krone; Rossella Libé; Franco Mantero; Peter Nightingale; Giuseppe Opocher; Emilio Porfiri; Petra Schneider; Cedric H L Shackleton; David J Smith; Han Stiekema; Angela E Taylor; Massimo Terzolo; Bruno Allolio; Paul M Stewart
Urine steroid metabolomics as a biomarker tool for detecting malignancy in adrenal tumors.
The Journal of clinical endocrinology and metabolism 2011;96(12):3775-84.
2011: Mark S Cooper; William D Fraser; Hashir Kriel; Chris S Probert; Adrian Sayers; Paul M Stewart; Amanda M Williams; Jonathan H Tobias
Can 11β-hydroxysteroid dehydrogenase activity predict the sensitivity of bone to therapeutic glucocorticoids in inflammatory bowel disease?
Calcified tissue international 2011;89(3):246-51.
2011: Jan Idkowiak; Nils Krone; Gareth G Lavery; Paul M Stewart; Timothy G Barrett; Vivek Dhir; Wiebke Arlt
Premature adrenarche: novel lessons from early onset androgen excess.
European journal of endocrinology / European Federation of Endocrine Societies 2011;165(2):189-207.
2011: Zaki Hassan-Smith; Paul M Stewart
Inherited forms of mineralocorticoid hypertension.
Current opinion in endocrinology, diabetes, and obesity 2011;18(3):177-85.
2011: Agnieszka E Zielinska; Elizabeth A Walker; Paul M Stewart; Gareth G Lavery
Biochemistry and physiology of hexose-6-phosphate knockout mice.
Molecular and cellular endocrinology 2011;336(1-2):213-8.
2011: Laura L Gathercole; David Hauton; Stuart A Morgan; Paul M Stewart; Iwona J Bujalska; Jeremy W Tomlinson
Regulation of lipogenesis by glucocorticoids and insulin in human adipose tissue.
PloS one 2011;6(10):e26223.
2011: Julia Lepenies; Paul M Stewart; Paul Cockwell; Kevin S Eardley; Martin Hewison; Thomas Ihl; Tina Kienitz; Marcus Quinkler
Renal TLR4 mRNA expression correlates with inflammatory marker MCP-1 and profibrotic molecule TGF-β₁ in patients with chronic kidney disease.
Nephron. Clinical practice 2011;119(2):c97-c104.
2011: Nina M Semjonous; Mark Sherlock; Pancharatnam Jeyasuria; Keith L Parker; Elizabeth A Walker; Paul M Stewart; Gareth G Lavery
Hexose-6-phosphate dehydrogenase contributes to skeletal muscle homeostasis independent of 11β-hydroxysteroid dehydrogenase type 1.
Endocrinology 2011;152(1):93-102.
2011: Ana Tiganescu; Elizabeth A Walker; Rowan S Hardy; Andrew E Mayes; Paul M Stewart
Localization, age- and site-dependent expression, and regulation of 11β-hydroxysteroid dehydrogenase type 1 in skin.
The Journal of investigative dermatology 2011;131(1):30-6.
2010: AJ Sinclair; Elizabeth A Walker; Michael A Burdon; A van Beek; Ido P Kema; Beverly A Hughes; Philip I Murray; Peter Nightingale; Paul M Stewart; Saaeha Rauz; Jeremy W Tomlinson
Cerebrospinal fluid corticosteroid levels and cortisol metabolism in patients with idiopathic intracranial hypertension: a link between 11beta-HSD1 and intracranial pressure regulation?
The Journal of clinical endocrinology and metabolism 2010;95(12):5348-56.
2010: Nicola C Edwards; Charles J Ferro; Helen Kirkwood; Colin D Chue; Alistair A Young; Paul M Stewart; Richard Steeds; Jonathan N Townend
Effect of spironolactone on left ventricular systolic and diastolic function in patients with early stage chronic kidney disease.
The American journal of cardiology 2010;106(10):1505-11.
2010: Fabian Hammer; Nicola C Edwards; Beverly A Hughes; Richard Steeds; Charles J Ferro; Jonathan N Townend; Paul M Stewart
The effect of spironolactone upon corticosteroid hormone metabolism in patients with early stage chronic kidney disease.
Clinical endocrinology 2010;73(5):566-72.
2010: Nils Krone; Beverly A Hughes; Gareth G Lavery; Paul M Stewart; Wiebke Arlt; Cedric H L Shackleton
Gas chromatography/mass spectrometry (GC/MS) remains a pre-eminent discovery tool in clinical steroid investigations even in the era of fast liquid chromatography tandem mass spectrometry (LC/MS/MS).
The Journal of steroid biochemistry and molecular biology 2010;121(3-5):496-504.
2010: Mark Sherlock; John Ayuk; Jeremy W Tomlinson; Andrew A Toogood; Aurora Aragon-Alonso; Michael C Sheppard; Andrew S Bates; Paul M Stewart
Mortality in patients with pituitary disease.
Endocrine reviews 2010;31(3):301-42.
2010: K Kaur; R Hardy; M M Ahasan; M Eijken; J P van Leeuwen; Andrew Filer; A M Thomas; Karim Raza; Christopher D Buckley; Paul M Stewart; Elizabeth H Rabbitt; Martin Hewison; Mark S Cooper
Synergistic induction of local glucocorticoid generation by inflammatory cytokines and glucocorticoids: implications for inflammation associated bone loss.
Annals of the rheumatic diseases 2010;69(6):1185-90.
2010: Paul M Stewart; Bruno Allolio
Adrenal vein sampling for Primary Aldosteronism: time for a reality check.
Clinical endocrinology 2010;72(2):146-8.
2010: Alexandra J Sinclair; Mark R Viant; Alexandra K Ball; Michael A Burdon; Elizabeth A Walker; Paul M Stewart; Saaeha Rauz; Stephen P Young
NMR-based metabolomic analysis of cerebrospinal fluid and serum in neurological diseases--a diagnostic tool?
NMR in biomedicine 2010;23(2):123-32.
2010: AJ Sinclair; Michael A Burdon; Peter G Nightingale; Alexandra K Ball; Peter Good; Timothy D Matthews; Andrew Jacks; Mark Lawden; Carl Clarke; Paul M Stewart; Elizabeth A Walker; Jeremy W Tomlinson; Saaeha Rauz
Low energy diet and intracranial pressure in women with idiopathic intracranial hypertension: prospective cohort study.
BMJ (Clinical research ed.) 2010;341():c2701.
2010: Jeremy W Tomlinson; Omar M Durrani; Iwona J Bujalska; Laura L Gathercole; Paul J Tomlins; Tristan T Q Reuser; Geoffrey E Rose; S John Curnow; Paul M Stewart; Elizabeth A Walker; Saaeha Rauz
The role of 11beta-hydroxysteroid dehydrogenase 1 in adipogenesis in thyroid-associated ophthalmopathy.
The Journal of clinical endocrinology and metabolism 2010;95(1):398-406.
2009: Paul M Stewart; Stephan Petersenn
Rationale for treatment and therapeutic options in Cushing's disease.
Best practice & research. Clinical endocrinology & metabolism 2009;23 Suppl 1():S15-22.
2009: Mark Sherlock; Raoul C Reulen; A Aragon Alonso; John Ayuk; Richard N Clayton; Michael C Sheppard; M M Hawkins; Andrew S Bates; Paul M Stewart
ACTH deficiency, higher doses of hydrocortisone replacement, and radiotherapy are independent predictors of mortality in patients with acromegaly.
The Journal of clinical endocrinology and metabolism 2009;94(11):4216-23.
2009: Stuart A Morgan; Mark Sherlock; Laura L Gathercole; Gareth G Lavery; Carol Lenaghan; Iwona J Bujalska; David Laber; Alice Yu; Gemma Convey; Rachel Mayers; Krisztina Hegyi; Jaswinder Sethi; Paul M Stewart; David M Smith; Jeremy W Tomlinson
11beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle.
Diabetes 2009;58(11):2506-15.
2009: Dimitra A Vassiliadi; Thomas M Barber; Beverly A Hughes; Mark I McCarthy; John A H Wass; Stephen Franks; Peter Nightingale; Jeremy W Tomlinson; Wiebke Arlt; Paul M Stewart
Increased 5 alpha-reductase activity and adrenocortical drive in women with polycystic ovary syndrome.
The Journal of clinical endocrinology and metabolism 2009;94(9):3558-66.
2009: Nicola C Edwards; Richard P Steeds; Paul M Stewart; Charles J Ferro; Jonathan N Townend
Effect of spironolactone on left ventricular mass and aortic stiffness in early-stage chronic kidney disease: a randomized controlled trial.
Journal of the American College of Cardiology 2009;54(6):505-12.
2009: Nils Krone; Paul M Stewart
Adrenal function: An overlooked cause of glucocorticoid deficiency?
Nature reviews. Endocrinology 2009;5(7):362-3.
2009: Alexander J Lawson; Elizabeth A Walker; Scott A White; Timothy R Dafforn; Paul M Stewart; Jonathan P Ride
Mutations of key hydrophobic surface residues of 11 beta-hydroxysteroid dehydrogenase type 1 increase solubility and monodispersity in a bacterial expression system.
Protein science : a publication of the Protein Society 2009;18(7):1552-63.
2009: Mark Sherlock; A Aragon Alonso; Raoul C Reulen; John Ayuk; Richard N Clayton; Geoff Holder; Michael C Sheppard; A Bates; Paul M Stewart
Monitoring disease activity using GH and IGF-I in the follow-up of 501 patients with acromegaly.
Clinical endocrinology 2009;71(1):74-81.
2009: A K Ball; Alan J Sinclair; S John Curnow; Jeremy W Tomlinson; M A Burdon; E A Walker; Paul M Stewart; Peter Nightingale; Carl Clarke; Saaeha Rauz
Elevated cerebrospinal fluid (CSF) leptin in idiopathic intracranial hypertension (IIH): evidence for hypothalamic leptin resistance?
Clinical endocrinology 2009;70(6):863-9.
2009: Christopher S Shaw; Mark Sherlock; Paul M Stewart; Anton J M Wagenmakers
Adipophilin distribution and colocalization with lipid droplets in skeletal muscle.
Histochemistry and cell biology 2009;131(5):575-81.
2009: Paul M Stewart; Stephen M Prescott
Can licorice lick colon cancer?
The Journal of clinical investigation 2009;119(4):760-3.
2009: Mark Sherlock; E Fernandez-Rodriguez; A Aragon Alonso; Raoul C Reulen; John Ayuk; Richard N Clayton; Geoff Holder; Michael C Sheppard; A Bates; Paul M Stewart
Medical therapy in patients with acromegaly: predictors of response and comparison of efficacy of dopamine agonists and somatostatin analogues.
The Journal of clinical endocrinology and metabolism 2009;94(4):1255-63.
2009: Paul M Stewart; Penelope M Clark
The low-dose corticotropin-stimulation test revisited: the less, the better?
Nature clinical practice. Endocrinology & metabolism 2009;5(2):68-9.
2009: Fabian Hammer; Paul M Stewart
Investigating hypertension in a young person.
BMJ (Clinical research ed.) 2009;338():b1043.
2009: Paul M Stewart; Jeremy W Tomlinson
Selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 for patients with metabolic syndrome: is the target liver, fat, or both?
Diabetes 2009;58(1):14-5.
2009: Eva Fernandez-Rodriguez; Paul M Stewart; Mark S Cooper
The pituitary-adrenal axis and body composition.
Pituitary 2009;12(2):105-15.
2009: John Ayuk; Paul M Stewart
Mortality following pituitary radiotherapy.
Pituitary 2009;12(1):35-9.
2008: Daniel Zehnder; Marcus Quinkler; Kevin S Eardley; Rosemary Bland; Julia Lepenies; Susan V Hughes; Neil T Raymond; Alexander J Howie; Paul Cockwell; Paul M Stewart; Martin Hewison
Reduction of the vitamin D hormonal system in kidney disease is associated with increased renal inflammation.
Kidney international 2008;74(10):1343-53.
2008: A Swali; Elizabeth A Walker; Gareth G Lavery; Jeremy W Tomlinson; Paul M Stewart
11beta-Hydroxysteroid dehydrogenase type 1 regulates insulin and glucagon secretion in pancreatic islets.
Diabetologia 2008;51(11):2003-11.
2008: Jeremy W Tomlinson; Joanne Finney; Christopher Gay; Beverly A Hughes; Susan V Hughes; Paul M Stewart
Impaired glucose tolerance and insulin resistance are associated with increased adipose 11beta-hydroxysteroid dehydrogenase type 1 expression and elevated hepatic 5alpha-reductase activity.
Diabetes 2008;57(10):2652-60.
2008: Gareth G Lavery; Elizabeth A Walker; Ana Tiganescu; Jonathan P Ride; Cedric H L Shackleton; Jeremy W Tomlinson; John M C Connell; David W Ray; Anna Biason-Lauber; Ewa M Malunowicz; Wiebke Arlt; Paul M Stewart
Steroid biomarkers and genetic studies reveal inactivating mutations in hexose-6-phosphate dehydrogenase in patients with cortisone reductase deficiency.
The Journal of clinical endocrinology and metabolism 2008;93(10):3827-32.
2008: Cedric H L Shackleton; Beverly A Hughes; Gareth G Lavery; Elizabeth A Walker; Paul M Stewart
The corticosteroid metabolic profile of the mouse.
Steroids 2008;73(11):1066-76.
2008: Alexandra J Sinclair; Alexandra K Ball; Michael A Burdon; Carl Clarke; Paul M Stewart; S John Curnow; Saaeha Rauz
Exploring the pathogenesis of IIH: an inflammatory perspective.
Journal of neuroimmunology 2008;201-202():212-20.
2008: R Hardy; Elizabeth H Rabbitt; A Filer; P Emery; Martin Hewison; Paul M Stewart; N J L Gittoes; Christopher D Buckley; K Raza; Mark S Cooper
Local and systemic glucocorticoid metabolism in inflammatory arthritis.
Annals of the rheumatic diseases 2008;67(9):1204-10.
2008: Cedric H L Shackleton; Marcos S Neres; Beverly A Hughes; Paul M Stewart; Claudio E Kater
17-Hydroxylase/C17,20-lyase (CYP17) is not the enzyme responsible for side-chain cleavage of cortisol and its metabolites.
Steroids 2008;73(6):652-6.
2008: Jeremy W Tomlinson; Joanne Finney; Beverly A Hughes; Susan V Hughes; Paul M Stewart
Reduced glucocorticoid production rate, decreased 5alpha-reductase activity, and adipose tissue insulin sensitization after weight loss.
Diabetes 2008;57(6):1536-43.
2008: Adeeba Ahmed; Sushma Saksena; Mark Sherlock; Simon P Olliff; Elwyn Elias; Paul M Stewart
Induction of hepatic 11beta-hydroxysteroid dehydrogenase type 1 in patients with alcoholic liver disease.
Clinical endocrinology 2008;68(6):898-903.
2008: Iwona J Bujalska; L L Gathercole; Jeremy W Tomlinson; C Darimont; J Ermolieff; A N Fanjul; Paul Rejto; Paul M Stewart
A novel selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitor prevents human adipogenesis.
The Journal of endocrinology 2008;197(2):297-307.
2008: Iwona J Bujalska; Kylie N Hewitt; David Hauton; Gareth G Lavery; Jeremy W Tomlinson; Elizabeth A Walker; Paul M Stewart
Lack of hexose-6-phosphate dehydrogenase impairs lipid mobilization from mouse adipose tissue.
Endocrinology 2008;149(5):2584-91.
2008: Mario Palermo; maria grazia marazzi; Beverly A Hughes; Paul M Stewart; Peter T Clayton; Cedric H L Shackleton
Human Delta4-3-oxosteroid 5beta-reductase (AKR1D1) deficiency and steroid metabolism.
Steroids 2008;73(4):417-23.
2008: Gareth G Lavery; Elizabeth A Walker; Nil Turan; Daniela Rogoff; Jeffery W Ryder; John M Shelton; James A Richardson; Francesco Falciani; Perrin C White; Paul M Stewart; Keith L Parker; Daniel R McMillan
Deletion of hexose-6-phosphate dehydrogenase activates the unfolded protein response pathway and induces skeletal myopathy.
The Journal of biological chemistry 2008;283(13):8453-61.
2008: Paul M Stewart; Anna Stears; Jeremy W Tomlinson; Morris J Brown
Regulation--the real threat to clinical research.
BMJ (Clinical research ed.) 2008;337():a1732.
2008: B Ganesh Bhat; Natilie Hosea; Andrea Fanjul; Jocelyn Herrera; Justin Chapman; Fred Thalacker; Paul M Stewart; Paul Rejto
Demonstration of proof of mechanism and pharmacokinetics and pharmacodynamic relationship with 4'-cyano-biphenyl-4-sulfonic acid (6-amino-pyridin-2-yl)-amide (PF-915275), an inhibitor of 11 -hydroxysteroid dehydrogenase type 1, in cynomolgus monkeys.
The Journal of pharmacology and experimental therapeutics 2008;324(1):299-305.
2007: Jeremy W Tomlinson; Paul M Stewart
Modulation of glucocorticoid action and the treatment of type-2 diabetes.
Best practice & research. Clinical endocrinology & metabolism 2007;21(4):607-19.
2007: Edward B Alabraba; Philippe Taniere; Gary M Reynolds; Paul M Stewart; Stephen Wigmore; Simon R Bramhall
Expression and functional consequences of oestrogen and progesterone receptors in human insulinomas.
Endocrine-related cancer 2007;14(4):1081-8.
2007: Gareth G Lavery; David Hauton; Kylie N Hewitt; Sophie M Brice; Mark Sherlock; Elizabeth A Walker; Paul M Stewart
Hypoglycemia with enhanced hepatic glycogen synthesis in recombinant mice lacking hexose-6-phosphate dehydrogenase.
Endocrinology 2007;148(12):6100-6.
2007: P Gerry Fegan; Derek D Sandeman; Nils Krone; Deborah Bosman; Peter J Wood; Paul M Stewart; Neil A Hanley
Cushing's syndrome in women with polycystic ovaries and hyperandrogenism.
Nature clinical practice. Endocrinology & metabolism 2007;3(11):778-83.
2007: Laura L Gathercole; Iwona J Bujalska; Paul M Stewart; Jeremy W Tomlinson
Glucocorticoid modulation of insulin signaling in human subcutaneous adipose tissue.
The Journal of clinical endocrinology and metabolism 2007;92(11):4332-9.
2007: Junny Chan; Elizabeth H Rabbitt; Barbara A Innes; Judith N Bulmer; Paul M Stewart; Mark D Kilby; Martin Hewison
Glucocorticoid-induced apoptosis in human decidua: a novel role for 11beta-hydroxysteroid dehydrogenase in late gestation.
The Journal of endocrinology 2007;195(1):7-15.
2007: Elizabeth A Walker; Adeeba Ahmed; Gareth G Lavery; Jeremy W Tomlinson; So Youn Kim; Mark S Cooper; Jonathan P Ride; Beverly A Hughes; Cedric H L Shackleton; Patrick J McKiernan; Elwyn Elias; Janice Y Chou; Paul M Stewart
11beta-Hydroxysteroid Dehydrogenase Type 1 Regulation by Intracellular Glucose 6-Phosphate Provides Evidence for a Novel Link between Glucose Metabolism and Hypothalamo-Pituitary-Adrenal Axis Function.
The Journal of biological chemistry 2007;282(37):27030-6.
2007: A J Sinclair; Claire U Onyimba; Pamela Khosla; N Vijapurapu; Jeremy W Tomlinson; M A Burdon; Paul M Stewart; Philip I Murray; Elizabeth A Walker; Saaeha Rauz
Corticosteroids, 11beta-hydroxysteroid dehydrogenase isozymes and the rabbit choroid plexus.
Journal of neuroendocrinology 2007;19(8):614-20.
2007: Vivek Dhir; Hannah E Ivison; Nils Krone; Cedric H L Shackleton; Aidan J Doherty; Paul M Stewart; Wiebke Arlt
Differential inhibition of CYP17A1 and CYP21A2 activities by the P450 oxidoreductase mutant A287P.
Molecular endocrinology (Baltimore, Md.) 2007;21(8):1958-68.
2007: Jeremy W Tomlinson; Mark Sherlock; Beverley Hughes; Susan V Hughes; Fiona Kilvington; William A Bartlett; Rachel Courtney; Paul Rejto; William Carley; Paul M Stewart
Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 activity in vivo limits glucocorticoid exposure to human adipose tissue and decreases lipolysis.
The Journal of clinical endocrinology and metabolism 2007;92(3):857-64.
2007: Iwona J Bujalska; Omar M Durrani; Joseph Abbott; Claire U Onyimba; Pamela Khosla; Areeb H Moosavi; Tristan T Q Reuser; Paul M Stewart; Jeremy W Tomlinson; Elizabeth A Walker; Saaeha Rauz
Characterisation of 11beta-hydroxysteroid dehydrogenase 1 in human orbital adipose tissue: a comparison with subcutaneous and omental fat.
The Journal of endocrinology 2007;192(2):279-88.
2006: Iwona J Bujalska; Marcus Quinkler; Jeremy W Tomlinson; Montague Carl; D M Smith; Paul M Stewart
Expression profiling of 11beta-hydroxysteroid dehydrogenase type-1 and glucocorticoid-target genes in subcutaneous and omental human preadipocytes.
Journal of molecular endocrinology 2006;37(2):327-40.
2006: Marcus Quinkler; Iwona J Bujalska; Jeremy W Tomlinson; Dave M Smith; Paul M Stewart
Depot-specific prostaglandin synthesis in human adipose tissue: a novel possible mechanism of adipogenesis.
Gene 2006;380(2):137-43.
2006: Fabian Hammer; Paul M Stewart
Cortisol metabolism in hypertension.
Best practice & research. Clinical endocrinology & metabolism 2006;20(3):337-53.
2006: Claire U Onyimba; Neelima Vijapurapu; S John Curnow; Pamela Khosla; Paul M Stewart; Philip I Murray; Elizabeth A Walker; Saaeha Rauz
Characterisation of the prereceptor regulation of glucocorticoids in the anterior segment of the rabbit eye.
The Journal of endocrinology 2006;190(2):483-93.
2006: Nicole Draper; Brenda L Powell; Steve Franks; Gerard S Conway; Paul M Stewart; Mark I McCarthy
Variants implicated in cortisone reductase deficiency do not contribute to susceptibility to common forms of polycystic ovary syndrome.
Clinical endocrinology 2006;65(1):64-70.
2006: Wiebke Arlt; Fabian Hammer; Petra Sanning; Stephen K Butcher; J Michael Lord; Bruno Allolio; Djillali Annane; Paul M Stewart
Dissociation of serum dehydroepiandrosterone and dehydroepiandrosterone sulfate in septic shock.
The Journal of clinical endocrinology and metabolism 2006;91(7):2548-54.
2006: Claire M Banwell; Donia P MacCartney; Michelle Guy; Alice E Miles; Milan R Uskokovic; Janine L Mansi; Paul M Stewart; Laura P O'Neill; Bryan M Turner; Kay W Colston; Moray J Campbell
Altered nuclear receptor corepressor expression attenuates vitamin D receptor signaling in breast cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(7 Pt 1):2004-13.
2006: Paul J Jenkins; P Bates; M N Carson; Paul M Stewart; J A H Wass
Conventional pituitary irradiation is effective in lowering serum growth hormone and insulin-like growth factor-I in patients with acromegaly.
The Journal of clinical endocrinology and metabolism 2006;91(4):1239-45.
2006: Gareth G Lavery; Elizabeth A Walker; Nicole Draper; Pancharatnam Jeyasuria; Josep Marcos del Aguila; Cedric H L Shackleton; Keith L Parker; Perrin C White; Paul M Stewart
Hexose-6-phosphate dehydrogenase knock-out mice lack 11 beta-hydroxysteroid dehydrogenase type 1-mediated glucocorticoid generation.
The Journal of biological chemistry 2006;281(10):6546-51.
2006: Kelly Towsend; Victor Trevino; Francesco Falciani; Paul M Stewart; Martin Hewison; Moray J Campbell
Identification of VDR-responsive gene signatures in breast cancer cells.
Oncology 2006;71(1-2):111-23.
2006: Anton J M Wagenmakers; Natal van Riel; Michael P Frenneaux; Paul M Stewart
Integration of the metabolic and cardiovascular effects of exercise.
Essays in biochemistry 2006;42():193-210.
2006: Rowan S Hardy; Andrew Filer; Mark S Cooper; Greg Parsonage; Karim Raza; Debbie L Hardie; Elizabeth H Rabbitt; Paul M Stewart; Christopher D Buckley; Martin Hewison
Differential expression, function and response to inflammatory stimuli of 11beta-hydroxysteroid dehydrogenase type 1 in human fibroblasts: a mechanism for tissue-specific regulation of inflammation.
Arthritis research & therapy 2006;8(4):R108.
2006: Amar Agha; Jeremy W Tomlinson; Penny M S Clark; Geoff Holder; Paul M Stewart
The long-term predictive accuracy of the short synacthen (corticotropin) stimulation test for assessment of the hypothalamic-pituitary-adrenal axis.
The Journal of clinical endocrinology and metabolism 2006;91(1):43-7.
2005: Jeremy W Tomlinson; Paul M Stewart
Mechanisms of disease: Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome.
Nature clinical practice. Endocrinology & metabolism 2005;1(2):92-9.
2005: Fabian Hammer; Daniel G Drescher; Susanne B Schneider; Marcus Quinkler; Paul M Stewart; Bruno Allolio; Wiebke Arlt
Sex steroid metabolism in human peripheral blood mononuclear cells changes with aging.
The Journal of clinical endocrinology and metabolism 2005;90(11):6283-9.
2005: Marcus Quinkler; Iwona J Bujalska; Kirren Kaur; Claire U Onyimba; Sabine Buhner; Bruno Allolio; Susan V Hughes; Martin Hewison; Paul M Stewart
Androgen receptor-mediated regulation of the alpha-subunit of the epithelial sodium channel in human kidney.
Hypertension 2005;46(4):787-98.
2005: Marcus Quinkler; Daniel Zehnder; Kevin S Eardley; Julia Lepenies; Alexander J Howie; Susan V Hughes; Paul Cockwell; Martin Hewison; Paul M Stewart
Increased expression of mineralocorticoid effector mechanisms in kidney biopsies of patients with heavy proteinuria.
Circulation 2005;112(10):1435-43.
2005: Mary H Bassett; Bobbie A Mayhew; Khurram S Rehman; Perrin C White; Franco Mantero; Giorgio Arnaldi; Paul M Stewart; Iwona J Bujalska; William E Rainey
Expression profiles for steroidogenic enzymes in adrenocortical disease.
The Journal of clinical endocrinology and metabolism 2005;90(9):5446-55.
2005: Barbara Mariniello; Vanessa Ronconi; Cipriana Sardu; Antonella Pagliericcio; Ferruccio Galletti; Pasquale Strazzullo; Mario Palermo; Marco Boscaro; Paul M Stewart; Franco Mantero; Gilberta Giacchetti
Analysis of the 11beta-hydroxysteroid dehydrogenase type 2 gene (HSD11B2) in human essential hypertension.
American journal of hypertension 2005;18(8):1091-8.
2005: John Ayuk; Michael C Sheppard; Andrew S Bates; Paul M Stewart
Letter re: Monitoring the response to treatment in acromegaly.
The Journal of clinical endocrinology and metabolism 2005;90(8):4980.
2005: Nicole Draper; Paul M Stewart
11beta-hydroxysteroid dehydrogenase and the pre-receptor regulation of corticosteroid hormone action.
The Journal of endocrinology 2005;186(2):251-71.
2005: Marcus Quinkler; Daniel Zehnder; Julia Lepenies; Massimiliano D Petrelli; Jasbir S Moore; Susan V Hughes; Paul Cockwell; Martin Hewison; Paul M Stewart
Expression of renal 11beta-hydroxysteroid dehydrogenase type 2 is decreased in patients with impaired renal function.
European journal of endocrinology / European Federation of Endocrine Societies 2005;153(2):291-9.
2005: Iwona J Bujalska; Nicole Draper; Zoi Michailidou; Jeremy W Tomlinson; Perrin C White; Karen E Chapman; Elizabeth A Walker; Paul M Stewart
Hexose-6-phosphate dehydrogenase confers oxo-reductase activity upon 11 beta-hydroxysteroid dehydrogenase type 1.
Journal of molecular endocrinology 2005;34(3):675-84.
2005: Mark S Cooper; Holly E Syddall; Caroline H D Fall; Peter J Wood; Paul M Stewart; Cyrus Cooper; Elaine M Dennison
Circulating cortisone levels are associated with biochemical markers of bone formation and lumbar spine BMD: the Hertfordshire Cohort Study.
Clinical endocrinology 2005;62(6):692-7.
2005: Wiebke Arlt; Paul M Stewart
Adrenal corticosteroid biosynthesis, metabolism, and action.
Endocrinology and metabolism clinics of North America 2005;34(2):293-313, viii.
2005: Kylie N Hewitt; Elizabeth A Walker; Paul M Stewart
Minireview: hexose-6-phosphate dehydrogenase and redox control of 11{beta}-hydroxysteroid dehydrogenase type 1 activity.
Endocrinology 2005;146(6):2539-43.
2005: Fabian Hammer; Sandra Subtil; Philipp Lux; Christiane Maser-Gluth; Paul M Stewart; Bruno Allolio; Wiebke Arlt
No evidence for hepatic conversion of dehydroepiandrosterone (DHEA) sulfate to DHEA: in vivo and in vitro studies.
The Journal of clinical endocrinology and metabolism 2005;90(6):3600-5.
2005: Kelly Townsend; Claire M Banwell; Michelle Guy; Kay W Colston; Janine L Mansi; Paul M Stewart; Moray J Campbell; Martin Hewison
Autocrine metabolism of vitamin D in normal and malignant breast tissue.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(9):3579-86.
2005: Paul M Stewart
Tissue-specific Cushing's syndrome uncovers a new target in treating the metabolic syndrome--11beta-hydroxysteroid dehydrogenase type 1.
Clinical medicine (London, England) 2005;5(2):142-6.
2005: Mark S Cooper; Paul M Stewart
Diagnosis and treatment of ACTH deficiency.
Reviews in endocrine & metabolic disorders 2005;6(1):47-54.
2004: Stefan A Wudy; Michaela F Hartmann; Nicole Draper; Paul M Stewart; Wiebke Arlt
A male twin infant with skull deformity and elevated neonatal 17-hydroxyprogesterone: a prismatic case of P450 oxidoreductase deficiency.
Endocrine research 2004;30(4):957-64.
2004: Marcus Quinkler; Binayak Sinha; Jeremy W Tomlinson; Iwona J Bujalska; Paul M Stewart; Wiebke Arlt
Androgen generation in adipose tissue in women with simple obesity--a site-specific role for 17beta-hydroxysteroid dehydrogenase type 5.
The Journal of endocrinology 2004;183(2):331-42.
2004: John Ayuk; Michael C Sheppard; Richard N Clayton; Andrew S Bates; Paul M Stewart
Evidence for the use of igf-I as a predictor of mortality in acromegaly is lacking.
The Journal of clinical endocrinology and metabolism 2004;89(11):5867-8; author reply 5868.
2004: Paul M Stewart
Acromegaly databases--time for European unification.
European journal of endocrinology / European Federation of Endocrine Societies 2004;151(4):431-2.
2004: Jeremy W Tomlinson; Elizabeth A Walker; Iwona J Bujalska; Nicole Draper; Gareth G Lavery; Mark S Cooper; Martin Hewison; Paul M Stewart
11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response.
Endocrine reviews 2004;25(5):831-66.
2004: Farhat L Khanim; Lyndon M Gommersall; Victoria H J Wood; Kirsty L Smith; Leire Montalvo; Laura P O'Neill; Yue Xu; Donna M Peehl; Paul M Stewart; Bryan M Turner; Moray J Campbell
Altered SMRT levels disrupt vitamin D3 receptor signalling in prostate cancer cells.
Oncogene 2004;23(40):6712-25.
2004: George Valsamakis; Aresh J Anwar; Jeremy W Tomlinson; Cedric H L Shackleton; Philip G McTernan; Rajkumar Chetty; Peter J Wood; A K Banerjee; Geoff Holder; Anthony H Barnett; Paul M Stewart; Sudhesh Kumar
11beta-hydroxysteroid dehydrogenase type 1 activity in lean and obese males with type 2 diabetes mellitus.
The Journal of clinical endocrinology and metabolism 2004;89(9):4755-61.
2004: Wiebke Arlt; Elizabeth A Walker; Nicole Draper; Hannah E Ivison; Jonathan P Ride; Fabian Hammer; Susan M Chalder; Maria Borucka-Mankiewicz; Berthold P Hauffa; Ewa M Malunowicz; Paul M Stewart; Cedric H L Shackleton
Congenital adrenal hyperplasia caused by mutant P450 oxidoreductase and human androgen synthesis: analytical study.
Lancet 2004;363(9427):2128-35.
2004: Jeremy W Tomlinson; Jasbir S Moore; Penny M S Clark; Geoff Holder; Lynette Shakespeare; Paul M Stewart
Weight loss increases 11beta-hydroxysteroid dehydrogenase type 1 expression in human adipose tissue.
The Journal of clinical endocrinology and metabolism 2004;89(6):2711-6.
2004: John Ayuk; Richard N Clayton; Geoff Holder; Michael C Sheppard; Paul M Stewart; Andrew S Bates
Growth hormone and pituitary radiotherapy, but not serum insulin-like growth factor-I concentrations, predict excess mortality in patients with acromegaly.
The Journal of clinical endocrinology and metabolism 2004;89(4):1613-7.
2004: Marcus Quinkler; B Bappal; Nicole Draper; A J Atterbury; Gareth G Lavery; Elizabeth A Walker; V DeSilva; N F Taylor; S Hala; N Rajendra; Paul M Stewart
Molecular basis for the apparent mineralocorticoid excess syndrome in the Oman population.
Molecular and cellular endocrinology 2004;217(1-2):143-9.
2004: John Ayuk; Susan E Stewart; Paul M Stewart; Michael C Sheppard
Efficacy of Sandostatin LAR (long-acting somatostatin analogue) is similar in patients with untreated acromegaly and in those previously treated with surgery and/or radiotherapy.
Clinical endocrinology 2004;60(3):375-81.
2004: Jeremy W Tomlinson; Paul M Stewart
"Cushing's disease of the omentum"--fact or fiction?
Journal of endocrinological investigation 2004;27(2):171-4.
2003: PM Driver; Saaeha Rauz; Elizabeth A Walker; Martin Hewison; Mark D Kilby; Paul M Stewart
Characterization of human trophoblast as a mineralocorticoid target tissue.
Molecular human reproduction 2003;9(12):793-8.
2003: Elizabeth A Walker; Paul M Stewart
11beta-hydroxysteroid dehydrogenase: unexpected connections.
Trends in endocrinology and metabolism: TEM 2003;14(7):334-9.
2003: Paul M Stewart
Tissue-specific Cushing's syndrome, 11beta-hydroxysteroid dehydrogenases and the redefinition of corticosteroid hormone action.
European journal of endocrinology / European Federation of Endocrine Societies 2003;149(3):163-8.
2003: Mark S Cooper; Aubrey Blumsohn; Philippa E Goddard; William A Bartlett; Cedric H L Shackleton; Ana Munoz; Martin Hewison; Paul M Stewart
11beta-hydroxysteroid dehydrogenase type 1 activity predicts the effects of glucocorticoids on bone.
The Journal of clinical endocrinology and metabolism 2003;88(8):3874-7.
2003: Gareth G Lavery; Vanessa Ronconi; Nicole Draper; Elizabeth H Rabbitt; Val Lyons; Karen E Chapman; Elizabeth A Walker; Claire L McTernan; Gilberta Giacchetti; Franco Mantero; Jonathan R Seckl; Christopher R W Edwards; John M C Connell; Martin Hewison; Paul M Stewart
Late-onset apparent mineralocorticoid excess caused by novel compound heterozygous mutations in the HSD11B2 gene.
Hypertension 2003;42(2):123-9.
2003: Nicole Draper; Elizabeth A Walker; Iwona J Bujalska; Jeremy W Tomlinson; Susan M Chalder; Wiebke Arlt; Gareth G Lavery; Oliver Bedendo; David W Ray; Ian Laing; Ewa M Malunowicz; Perrin C White; Martin Hewison; Philip Mason; John M C Connell; Cedric H L Shackleton; Paul M Stewart
Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency.
Nature genetics 2003;34(4):434-9.
2003: Saaeha Rauz; C M G Cheung; Peter J Wood; Miguel Coca-Prados; Elizabeth A Walker; Philip I Murray; Paul M Stewart
Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 lowers intraocular pressure in patients with ocular hypertension.
QJM : monthly journal of the Association of Physicians 2003;96(7):481-90.
2003: Saaeha Rauz; Elizabeth A Walker; Philip I Murray; Paul M Stewart
Expression and distribution of the serum and glucocorticoid regulated kinase and the epithelial sodium channel subunits in the human cornea.
Experimental eye research 2003;77(1):101-8.
2003: Elizabeth H Rabbitt; N J L Gittoes; Paul M Stewart; Martin Hewison
11beta-hydroxysteroid dehydrogenases, cell proliferation and malignancy.
The Journal of steroid biochemistry and molecular biology 2003;85(2-5):415-21.
2003: Marcus Quinkler; Paul M Stewart
Hypertension and the cortisol-cortisone shuttle.
The Journal of clinical endocrinology and metabolism 2003;88(6):2384-92.
2003: Jeremy W Tomlinson; Nicola Crabtree; Penny M S Clark; Geoff Holder; Andrew A Toogood; Cedric H L Shackleton; Paul M Stewart
Low-dose growth hormone inhibits 11 beta-hydroxysteroid dehydrogenase type 1 but has no effect upon fat mass in patients with simple obesity.
The Journal of clinical endocrinology and metabolism 2003;88(5):2113-8.
2003: Paul M Stewart
Pegvisomant: an advance in clinical efficacy in acromegaly.
European journal of endocrinology / European Federation of Endocrine Societies 2003;148 Suppl 2():S27-32.
2003: Saaeha Rauz; Elizabeth A Walker; Susan V Hughes; Miguel Coca-Prados; Martin Hewison; Philip I Murray; Paul M Stewart
Serum- and glucocorticoid-regulated kinase isoform-1 and epithelial sodium channel subunits in human ocular ciliary epithelium.
Investigative ophthalmology & visual science 2003;44(4):1643-51.
2003: Elizabeth H Rabbitt; John Ayuk; Kristien Boelaert; Michael C Sheppard; Martin Hewison; Paul M Stewart; N J L Gittoes
Abnormal expression of 11 beta-hydroxysteroid dehydrogenase type 2 in human pituitary adenomas: a prereceptor determinant of pituitary cell proliferation.
Oncogene 2003;22(11):1663-7.
2003: Mark S Cooper; Paul M Stewart
Corticosteroid insufficiency in acutely ill patients.
The New England journal of medicine 2003;348(8):727-34.
2003: Claire M Banwell; Rena Singh; Paul M Stewart; Milan R Uskokovic; Moray J Campbell
Antiproliferative signalling by 1,25(OH)2D3 in prostate and breast cancer is suppressed by a mechanism involving histone deacetylation.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 2003;164():83-98.
2002: Jeremy W Tomlinson; B Sinha; Iwona J Bujalska; Martin Hewison; Paul M Stewart
Expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue is not increased in human obesity.
The Journal of clinical endocrinology and metabolism 2002;87(12):5630-5.
2002: Jeremy W Tomlinson; Paul M Stewart
The functional consequences of 11beta-hydroxysteroid dehydrogenase expression in adipose tissue.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2002;34(11-12):746-51.
2002: Iwona J Bujalska; Elizabeth A Walker; Jeremy W Tomlinson; Martin Hewison; Paul M Stewart
11Beta-hydroxysteroid dehydrogenase type 1 in differentiating omental human preadipocytes: from de-activation to generation of cortisol.
Endocrine research 2002;28(4):449-61.
2002: Nicole Draper; S M Echwald; Gareth G Lavery; Elizabeth A Walker; R Fraser; E Davies; Thorkild I A Sørensen; A Astrup; J Adamski; Martin Hewison; John M C Connell; O Pedersen; Paul M Stewart
Association studies between microsatellite markers within the gene encoding human 11beta-hydroxysteroid dehydrogenase type 1 and body mass index, waist to hip ratio, and glucocorticoid metabolism.
The Journal of clinical endocrinology and metabolism 2002;87(11):4984-90.
2002: John Ayuk; Susan E Stewart; Paul M Stewart; Michael C Sheppard
Long-term safety and efficacy of depot long-acting somatostatin analogs for the treatment of acromegaly.
The Journal of clinical endocrinology and metabolism 2002;87(9):4142-6.
2002: Daniel Zehnder; Katie N Evans; Mark D Kilby; Judith N Bulmer; Barbara A Innes; Paul M Stewart; Martin Hewison
The ontogeny of 25-hydroxyvitamin D(3) 1alpha-hydroxylase expression in human placenta and decidua.
The American journal of pathology 2002;161(1):105-14.
2002: Mark S Cooper; Elizabeth H Rabbitt; Philippa E Goddard; William A Bartlett; Martin Hewison; Paul M Stewart
Osteoblastic 11beta-hydroxysteroid dehydrogenase type 1 activity increases with age and glucocorticoid exposure.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002;17(6):979-86.
2002: Gareth G Lavery; Claire L McTernan; Stephen C Bain; Tahseen A Chowdhury; Martin Hewison; Paul M Stewart
Association studies between the HSD11B2 gene (encoding human 11beta-hydroxysteroid dehydrogenase type 2), type 1 diabetes mellitus and diabetic nephropathy.
European journal of endocrinology / European Federation of Endocrine Societies 2002;146(4):553-8.
2002: Jackson C Kirkman-Brown; Linda Lefièvre; C Bray; Paul M Stewart; Christopher L R Barratt; Stephen Publicover
Inhibitors of receptor tyrosine kinases do not suppress progesterone-induced [Ca2+]i signalling in human spermatozoa.
Molecular human reproduction 2002;8(4):326-32.
2002: Philip G McTernan; Leah A Anderson; Aresh J Anwar; Sundaram Ramasamy; John Crocker; Anthony H Barnett; Paul M Stewart; Sudhesh Kumar
Glucocorticoid regulation of p450 aromatase activity in human adipose tissue: gender and site differences.
The Journal of clinical endocrinology and metabolism 2002;87(3):1327-36.
2002: Iwona J Bujalska; Elizabeth A Walker; Martin Hewison; Paul M Stewart
A switch in dehydrogenase to reductase activity of 11 beta-hydroxysteroid dehydrogenase type 1 upon differentiation of human omental adipose stromal cells.
The Journal of clinical endocrinology and metabolism 2002;87(3):1205-10.
2002: Daniel Zehnder; Rosemary Bland; Ravinder S Chana; David C Wheeler; Alexander J Howie; Mary C Williams; Paul M Stewart; Martin Hewison
Synthesis of 1,25-dihydroxyvitamin D(3) by human endothelial cells is regulated by inflammatory cytokines: a novel autocrine determinant of vascular cell adhesion.
Journal of the American Society of Nephrology : JASN 2002;13(3):621-9.
2002: Jeremy W Tomlinson; Nicole Draper; Joanna Mackie; Alan P Johnson; Geoff Holder; Peter Wood; Paul M Stewart
Absence of Cushingoid phenotype in a patient with Cushing's disease due to defective cortisone to cortisol conversion.
The Journal of clinical endocrinology and metabolism 2002;87(1):57-62.
2002: Elizabeth H Rabbitt; Gareth G Lavery; Elizabeth A Walker; Mark S Cooper; Paul M Stewart; Martin Hewison
Prereceptor regulation of glucocorticoid action by 11beta-hydroxysteroid dehydrogenase: a novel determinant of cell proliferation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(1):36-44.
2001: Claire L McTernan; Nicole Draper; H Nicholson; Susan M Chalder; PM Driver; Martin Hewison; Mark D Kilby; Paul M Stewart
Reduced placental 11beta-hydroxysteroid dehydrogenase type 2 mRNA levels in human pregnancies complicated by intrauterine growth restriction: an analysis of possible mechanisms.
The Journal of clinical endocrinology and metabolism 2001;86(10):4979-83.
2001: Rosemary Bland; Daniel Zehnder; Susan V Hughes; Pierre M Ronco; Paul M Stewart; Martin Hewison
Regulation of vitamin D-1alpha-hydroxylase in a human cortical collecting duct cell line.
Kidney international 2001;60(4):1277-86.
2001: Perrin C White; Anil Agarwal; A Li; H Nikkila; J H Pratt; M Caulfield; A Clark; Claire L McTernan; Paul M Stewart
Possible association but no linkage of the HSD11B2 gene encoding the kidney isozyme of 11beta-hydroxysteroid dehydrogenase to hypertension in Black people.
Clinical endocrinology 2001;55(2):249-52.
2001: Saaeha Rauz; Elizabeth A Walker; Cedric H L Shackleton; Martin Hewison; Philip I Murray; Paul M Stewart
Expression and putative role of 11 beta-hydroxysteroid dehydrogenase isozymes within the human eye.
Investigative ophthalmology & visual science 2001;42(9):2037-42.
2001: Elizabeth A Walker; A M Clark; Martin Hewison; Jonathan P Ride; Paul M Stewart
Functional expression, characterization, and purification of the catalytic domain of human 11-beta -hydroxysteroid dehydrogenase type 1.
The Journal of biological chemistry 2001;276(24):21343-50.
2001: Marta Korbonits; Iwona J Bujalska; M Shimojo; J Nobes; Suzanne Jordan; Ashley B Grossman; Paul M Stewart
Expression of 11 beta-hydroxysteroid dehydrogenase isoenzymes in the human pituitary: induction of the type 2 enzyme in corticotropinomas and other pituitary tumors.
The Journal of clinical endocrinology and metabolism 2001;86(6):2728-33.
2001: Mark S Cooper; Iwona J Bujalska; Elizabeth H Rabbitt; Elizabeth A Walker; Rosemary Bland; Michael C Sheppard; Martin Hewison; Paul M Stewart
Modulation of 11beta-hydroxysteroid dehydrogenase isozymes by proinflammatory cytokines in osteoblasts: an autocrine switch from glucocorticoid inactivation to activation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2001;16(6):1037-44.
2001: Jeremy W Tomlinson; J Moore; Mark S Cooper; Iwona J Bujalska; Mohsen Shahmanesh; C Burt; Alastair J Strain; Martin Hewison; Paul M Stewart
Regulation of expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue: tissue-specific induction by cytokines.
Endocrinology 2001;142(5):1982-9.
2001: PM Driver; Mark D Kilby; Iwona J Bujalska; Elizabeth A Walker; Martin Hewison; Paul M Stewart
Expression of 11 beta-hydroxysteroid dehydrogenase isozymes and corticosteroid hormone receptors in primary cultures of human trophoblast and placental bed biopsies.
Molecular human reproduction 2001;7(4):357-63.
2001: Jeremy W Tomlinson; Paul M Stewart
Cortisol metabolism and the role of 11beta-hydroxysteroid dehydrogenase.
Best practice & research. Clinical endocrinology & metabolism 2001;15(1):61-78.
2001: Jeremy W Tomlinson; N Holden; Robert K Hills; Keith Wheatley; Richard N Clayton; Andrew S Bates; Michael C Sheppard; Paul M Stewart
Association between premature mortality and hypopituitarism. West Midlands Prospective Hypopituitary Study Group.
Lancet 2001;357(9254):425-31.
2001: Daniel Zehnder; Rosemary Bland; M C Williams; R W McNinch; Alexander J Howie; Paul M Stewart; Martin Hewison
Extrarenal expression of 25-hydroxyvitamin d(3)-1 alpha-hydroxylase.
The Journal of clinical endocrinology and metabolism 2001;86(2):888-94.
2001: MA English; Paul M Stewart; Martin Hewison
Estrogen metabolism and malignancy: analysis of the expression and function of 17beta-hydroxysteroid dehydrogenases in colonic cancer.
Molecular and cellular endocrinology 2001;171(1-2):53-60.
2001: Paul M Stewart; Andrew A Toogood; Jeremy W Tomlinson
Growth hormone, insulin-like growth factor-I and the cortisol-cortisone shuttle.
Hormone research 2001;56 Suppl 1():1-6.
2001: LJ Eyre; Elizabeth H Rabbitt; Rosemary Bland; Susan V Hughes; Mark S Cooper; Michael C Sheppard; Paul M Stewart; Martin Hewison
Expression of 11 beta-hydroxysteroid dehydrogenase in rat osteoblastic cells: pre-receptor regulation of glucocorticoid responses in bone.
Journal of cellular biochemistry 2001;81(3):453-62.
2000: Perrin C White; Anil Agarwal; BS Nunez; Gilberta Giacchetti; Franco Mantero; Paul M Stewart
Genotype-phenotype correlations of mutations and polymorphisms in HSD11B2, the gene encoding the kidney isozyme of 11beta-hydroxysteroid dehydrogenase.
Endocrine research 2000;26(4):771-80.
2000: Jeremy W Tomlinson; Iwona J Bujalska; Paul M Stewart; Mark S Cooper
The role of 11 beta-hydroxysteroid dehydrogenase in central obesity and osteoporosis.
Endocrine research 2000;26(4):711-22.
2000: Martin Hewison; Daniel Zehnder; Rosemary Bland; Paul M Stewart
1alpha-Hydroxylase and the action of vitamin D.
Journal of molecular endocrinology 2000;25(2):141-8.
2000: Mark S Cooper; Elizabeth A Walker; Rosemary Bland; W D Fraser; Martin Hewison; Paul M Stewart
Expression and functional consequences of 11beta-hydroxysteroid dehydrogenase activity in human bone.
Bone 2000;27(3):375-81.
2000: Paul M Stewart
Dexamethasone-suppressible hypertension.
Lancet 2000;356(9231):697-9.
2000: Anil Agarwal; Gilberta Giacchetti; Gareth G Lavery; H Nikkila; M Palermo; M Ricketts; Claire L McTernan; G Bianchi; Paolo Manunta; Pasquale Strazzullo; Franco Mantero; Perrin C White; Paul M Stewart
CA-Repeat polymorphism in intron 1 of HSD11B2 : effects on gene expression and salt sensitivity.
Hypertension 2000;36(2):187-94.
2000: MA English; Susan V Hughes; K F Kane; M J S Langman; Paul M Stewart; Martin Hewison
Oestrogen inactivation in the colon: analysis of the expression and regulation of 17beta-hydroxysteroid dehydrogenase isozymes in normal colon and colonic cancer.
British journal of cancer 2000;83(4):550-8.
2000: Philip G McTernan; Aresh J Anwar; Sundaram Ramasamy; Anthony H Barnett; Paul M Stewart; Sudhesh Kumar
Gender differences in the regulation of P450 aromatase expression and activity in human adipose tissue.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2000;24(7):875-81.
2000: Jackson C Kirkman-Brown; C Bray; Paul M Stewart; Christopher L R Barratt; Stephen Publicover
Biphasic elevation of [Ca(2+)](i) in individual human spermatozoa exposed to progesterone.
Developmental biology 2000;222(2):326-35.
2000: Paul M Stewart
Current therapy for acromegaly.
Trends in endocrinology and metabolism: TEM 2000;11(4):128-32.
1999: Daniel Zehnder; Rosemary Bland; Elizabeth A Walker; Arthur R Bradwell; Alexander J Howie; Martin Hewison; Paul M Stewart
Expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in the human kidney.
Journal of the American Society of Nephrology : JASN 1999;10(12):2465-73.
1999: N J L Gittoes; Michael C Sheppard; A P Johnson; Paul M Stewart
Outcome of surgery for acromegaly--the experience of a dedicated pituitary surgeon.
QJM : monthly journal of the Association of Physicians 1999;92(12):741-5.
1999: Jasbir S Moore; John P Monson; Gregory A Kaltsas; Pietro Putignano; Peter J Wood; Michael C Sheppard; G Michael Besser; N F Taylor; Paul M Stewart
Modulation of 11beta-hydroxysteroid dehydrogenase isozymes by growth hormone and insulin-like growth factor: in vivo and in vitro studies.
The Journal of clinical endocrinology and metabolism 1999;84(11):4172-7.
1999: Mark S Cooper; Martin Hewison; Paul M Stewart
Glucocorticoid activity, inactivity and the osteoblast.
The Journal of endocrinology 1999;163(2):159-64.
1999: Paul M Stewart; R A James
The future of somatostatin analogue therapy.
Baillière's best practice & research. Clinical endocrinology & metabolism 1999;13(3):409-18.
1999: Paul M Stewart; P Clark
The short Synacthen test: is less best?
Clinical endocrinology 1999;51(2):151-2.
1999: Iwona J Bujalska; Sudhesh Kumar; Martin Hewison; Paul M Stewart
Differentiation of adipose stromal cells: the roles of glucocorticoids and 11beta-hydroxysteroid dehydrogenase.
Endocrinology 1999;140(7):3188-96.
1999: MA English; K F Kane; NR Cruickshank; M J S Langman; Paul M Stewart; Martin Hewison
Loss of estrogen inactivation in colonic cancer.
The Journal of clinical endocrinology and metabolism 1999;84(6):2080-5.
1999: ML Ricketts; Paul M Stewart
Regulation of 11beta-hydroxysteroid dehydrogenase type 2 by diuretics and the renin-angiotensin-aldosterone axis.
Clinical science (London, England : 1979) 1999;96(6):669-75.
1999: Rosemary Bland; C A Worker; B S Noble; LJ Eyre; Iwona J Bujalska; Michael C Sheppard; Paul M Stewart; Martin Hewison
Characterization of 11beta-hydroxysteroid dehydrogenase activity and corticosteroid receptor expression in human osteosarcoma cell lines.
The Journal of endocrinology 1999;161(3):455-64.
1999: Rosemary Bland; Elizabeth A Walker; Susan V Hughes; Paul M Stewart; Martin Hewison
Constitutive expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in a transformed human proximal tubule cell line: evidence for direct regulation of vitamin D metabolism by calcium.
Endocrinology 1999;140(5):2027-34.
1999: Paul M Stewart
Mineralocorticoid hypertension.
Lancet 1999;353(9161):1341-7.
1999: Paul M Stewart; Michael C Sheppard
Mortality and hypopituitarism.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 1999;9 Suppl A():15-9.
1999: Paul M Stewart
Cortisol as a mineralocorticoid in human disease.
The Journal of steroid biochemistry and molecular biology 1999;69(1-6):403-8.
1999: Andrew S Bates; BG Bullivant; Michael C Sheppard; Paul M Stewart
Life expectancy following surgery for pituitary tumours.
Clinical endocrinology 1999;50(3):315-9.
1999: Paul M Stewart; Susan E Stewart; P M Clark; Michael C Sheppard
Clinical and biochemical response following withdrawal of a long-acting, depot injection form of octreotide (Sandostatin-LAR).
Clinical endocrinology 1999;50(3):295-9.
1999: Paul M Stewart; A Boulton; Sudhesh Kumar; Penny M S Clark; Cedric H L Shackleton
Cortisol metabolism in human obesity: impaired cortisone-->cortisol conversion in subjects with central adiposity.
The Journal of clinical endocrinology and metabolism 1999;84(3):1022-7.
1999: Paul M Stewart; Zygmunt Krozowski
11 beta-Hydroxysteroid dehydrogenase.
Vitamins and hormones 1999;57():249-324.
1998: J Condon; Christine Gosden; Derek Gardener; P Nickson; Martin Hewison; Alexander J Howie; Paul M Stewart
Expression of type 2 11beta-hydroxysteroid dehydrogenase and corticosteroid hormone receptors in early human fetal life.
The Journal of clinical endocrinology and metabolism 1998;83(12):4490-7.
1998: A Li; Rinaldo Tedde; Zygmunt Krozowski; Antonello Pala; KX Li; Cedric H L Shackleton; Franco Mantero; Mario Palermo; Paul M Stewart
Molecular basis for hypertension in the "type II variant" of apparent mineralocorticoid excess.
American journal of human genetics 1998;63(2):370-9.
1998: LJ Eyre; Rosemary Bland; Iwona J Bujalska; Michael C Sheppard; Paul M Stewart; Martin Hewison
Characterization of aromatase and 17 beta-hydroxysteroid dehydrogenase expression in rat osteoblastic cells.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1998;13(6):996-1004.
1998: Peter J Trainer; Russell J Woods; Marta Korbonits; V Popovic; Paul M Stewart; P J Lowry; Ashley B Grossman
The pathophysiology of circulating corticotropin-releasing hormone-binding protein levels in the human.
The Journal of clinical endocrinology and metabolism 1998;83(5):1611-4.
1998: Munjiba Shams; Mark D Kilby; David A Somerset; Alexander J Howie; A Gupta; Peter J Wood; Masoud Afnan; Paul M Stewart
11Beta-hydroxysteroid dehydrogenase type 2 in human pregnancy and reduced expression in intrauterine growth restriction.
Human reproduction (Oxford, England) 1998;13(4):799-804.
1998: ML Ricketts; Julie Verhaeg; Iwona J Bujalska; Alexander J Howie; William E Rainey; Paul M Stewart
Immunohistochemical localization of type 1 11beta-hydroxysteroid dehydrogenase in human tissues.
The Journal of clinical endocrinology and metabolism 1998;83(4):1325-35.
1998: N J L Gittoes; Andrew S Bates; W Tse; BG Bullivant; Michael C Sheppard; Richard N Clayton; Paul M Stewart
Radiotherapy for non-function pituitary tumours.
Clinical endocrinology 1998;48(3):331-7.
1998: PH Davies; Susan E Stewart; L Lancranjan; Michael C Sheppard; Paul M Stewart
Long-term therapy with long-acting octreotide (Sandostatin-LAR) for the management of acromegaly.
Clinical endocrinology 1998;48(3):311-6.
1998: ML Ricketts; K J Shoesmith; Martin Hewison; Alastair J Strain; Sundaram Ramasamy; Paul M Stewart
Regulation of 11 beta-hydroxysteroid dehydrogenase type 1 in primary cultures of rat and human hepatocytes.
The Journal of endocrinology 1998;156(1):159-68.
1998: Massimiliano D Petrelli; Paul M Stewart
Monogenic forms of mineralocorticoid hypertension: insights into the pathogenesis of 'essential' hypertension?
Journal of human hypertension 1998;12(1):7-12.
1997: A Li; KX Li; Suemi Marui; Zygmunt Krozowski; M C Batista; C B Whorwood; I J Arnhold; Cedric H L Shackleton; B B Mendonca; Paul M Stewart
Apparent mineralocorticoid excess in a Brazilian kindred: hypertension in the heterozygote state.
Journal of hypertension 1997;15(12 Pt 1):1397-402.
1997: Susan V Hughes; E Robinson; Rosemary Bland; HM Lewis; Paul M Stewart; Martin Hewison
1,25-dihydroxyvitamin D3 regulates estrogen metabolism in cultured keratinocytes.
Endocrinology 1997;138(9):3711-8.
1997: Massimiliano D Petrelli; S S Lim-Tio; J Condon; Martin Hewison; Paul M Stewart
Differential expression of nuclear 11beta-hydroxysteroid dehydrogenase type 2 in mineralocorticoid receptor positive and negative tissues.
Endocrinology 1997;138(7):3077-80.
1997: Iwona J Bujalska; Sudhesh Kumar; Paul M Stewart
Does central obesity reflect "Cushing's disease of the omentum"?
Lancet 1997;349(9060):1210-3.
1997: J Condon; ML Ricketts; C B Whorwood; Paul M Stewart
Ontogeny and sexual dimorphic expression of mouse type 2 11beta-hydroxysteroid dehydrogenase.
Molecular and cellular endocrinology 1997;127(2):121-8.
1997: M Shimojo; ML Ricketts; Massimiliano D Petrelli; P Moradi; GD Johnson; Arthur R Bradwell; Martin Hewison; Alexander J Howie; Paul M Stewart
Immunodetection of 11 beta-hydroxysteroid dehydrogenase type 2 in human mineralocorticoid target tissues: evidence for nuclear localization.
Endocrinology 1997;138(3):1305-11.
1997: Iwona J Bujalska; M Shimojo; Alexander J Howie; Paul M Stewart
Human 11 beta-hydroxysteroid dehydrogenase: studies on the stably transfected isoforms and localization of the type 2 isozyme within renal tissue.
Steroids 1997;62(1):77-82.
1996: M Shimojo; J Condon; C B Whorwood; Paul M Stewart
Adrenal 11 beta-hydroxysteroid dehydrogenase.
Endocrine research 1996;22(4):771-80.
1996: M Shimojo; C B Whorwood; Paul M Stewart
11 beta-Hydroxysteroid dehydrogenase in the rat adrenal.
Journal of molecular endocrinology 1996;17(2):121-30.
1996: Michael C Sheppard; Paul M Stewart
Treatment options for acromegaly.
Metabolism: clinical and experimental 1996;45(8 Suppl 1):63-4.
1996: Paul M Stewart
11 beta-Hydroxysteroid dehydrogenase: implications for clinical medicine.
Clinical endocrinology 1996;44(5):493-9.
1996: Paul M Stewart; Zygmunt Krozowski; A Gupta; David V Milford; Alexander J Howie; Michael C Sheppard; C B Whorwood
Hypertension in the syndrome of apparent mineralocorticoid excess due to mutation of the 11 beta-hydroxysteroid dehydrogenase type 2 gene.
Lancet 1996;347(8994):88-91.
1995: Paul M Stewart; C B Whorwood; J I Mason
Type 2 11 beta-hydroxysteroid dehydrogenase in foetal and adult life.
The Journal of steroid biochemistry and molecular biology 1995;55(5-6):465-71.
1995: Paul M Stewart; B R Walker; G Holder; D O'Halloran; C H Shackleton
11 beta-Hydroxysteroid dehydrogenase activity in Cushing's syndrome: explaining the mineralocorticoid excess state of the ectopic adrenocorticotropin syndrome.
The Journal of clinical endocrinology and metabolism 1995;80(12):3617-20.
1995: F P Dunne; P Elliot; M D Gammage; T Stallard; T Ryan; Michael C Sheppard; Paul M Stewart
Cardiovascular function and glucocorticoid replacement in patients with hypopituitarism.
Clinical endocrinology 1995;43(5):623-9.
1995: D Jenkins; I O'Brien; A Johnson; R Shakespear; Michael C Sheppard; Paul M Stewart
The Birmingham pituitary database: auditing the outcome of the treatment of acromegaly.
Clinical endocrinology 1995;43(5):517-22.
1995: Paul M Stewart; K F Kane; Susan E Stewart; I Lancranjan; Michael C Sheppard
Depot long-acting somatostatin analog (Sandostatin-LAR) is an effective treatment for acromegaly.
The Journal of clinical endocrinology and metabolism 1995;80(11):3267-72.
1995: C B Whorwood; Paul M Stewart
Transcriptional regulation of Na/K-ATPase by corticosteroids, glycyrrhetinic acid and second messenger pathways in rat kidney epithelial cells.
Journal of molecular endocrinology 1995;15(1):93-103.
1995: M Shimojo; Paul M Stewart
Apparent mineralocorticoid excess syndromes.
Journal of endocrinological investigation 1995;18(7):518-32.
1995: C B Whorwood; J I Mason; ML Ricketts; Alexander J Howie; Paul M Stewart
Detection of human 11 beta-hydroxysteroid dehydrogenase isoforms using reverse-transcriptase-polymerase chain reaction and localization of the type 2 isoform to renal collecting ducts.
Molecular and cellular endocrinology 1995;110(1-2):R7-12.
1995: K F Kane; Paul Emery; Michael C Sheppard; Paul M Stewart
Assessing the hypothalamo-pituitary-adrenal axis in patients on long-term glucocorticoid therapy: the short synacthen versus the insulin tolerance test.
QJM : monthly journal of the Association of Physicians 1995;88(4):263-7.
1995: Paul M Stewart; J I Mason
Cortisol to cortisone: glucocorticoid to mineralocorticoid.
Steroids 1995;60(1):143-6.
1994: C B Whorwood; ML Ricketts; Paul M Stewart
Epithelial cell localization of type 2 11 beta-hydroxysteroid dehydrogenase in rat and human colon.
Endocrinology 1994;135(6):2533-41.
1994: S S Chaidarun; Sundaram Ramasamy; Paul M Stewart; Michael C Sheppard
Modulation of epidermal growth factor binding and receptor gene expression by hormones and growth factors in sheep pituitary cells.
The Journal of endocrinology 1994;143(3):489-96.
1994: S S Chaidarun; Sundaram Ramasamy; Michael C Sheppard; Paul M Stewart
Expression of epidermal growth factor (EGF), its receptor, and related oncoprotein (erbB-2) in human pituitary tumors and response to EGF in vitro.
Endocrinology 1994;135(5):2012-21.
1994: C B Whorwood; ML Ricketts; Paul M Stewart
Regulation of sodium-potassium adenosine triphosphate subunit gene expression by corticosteroids and 11 beta-hydroxysteroid dehydrogenase activity.
Endocrinology 1994;135(3):901-10.
1994: Paul M Stewart; Z Krozowski
Lessons from Appenberg: 11 beta-hydroxysteroid dehydrogenase 1B or 2?
The Journal of endocrinology 1994;141(2):191-3.
1994: Paul M Stewart
11 beta-Hydroxysteroid dehydrogenase.
Baillière's clinical endocrinology and metabolism 1994;8(2):357-78.
1994: S S Chaidarun; Sundaram Ramasamy; Paul M Stewart; PC Barber; Michael C Sheppard
Role of growth factors and estrogen as modulators of growth, differentiation, and expression of gonadotropin subunit genes in primary cultured sheep pituitary cells.
Endocrinology 1994;134(2):935-44.
1994: Paul M Stewart; C B Whorwood
11 beta-Hydroxysteroid dehydrogenase activity and corticosteroid hormone action.
Steroids 1994;59(2):90-5.
1994: Paul M Stewart; S Gibson; S R Crosby; R Penn; Roger L Holder; D Ferry; N Thatcher; P Phillips; D R London; A White
ACTH precursors characterize the ectopic ACTH syndrome.
Clinical endocrinology 1994;40(2):199-204.
1993: Paul M Stewart; C B Whorwood; B R Walker
Steroid hormones and hypertension: the cortisol-cortisone shuttle.
Steroids 1993;58(12):614-20.
1993: C B Whorwood; Michael C Sheppard; Paul M Stewart
Tissue specific effects of thyroid hormone on 11 beta-hydroxysteroid dehydrogenase gene expression.
The Journal of steroid biochemistry and molecular biology 1993;46(5):539-47.
1993: C B Whorwood; Michael C Sheppard; Paul M Stewart
Licorice inhibits 11 beta-hydroxysteroid dehydrogenase messenger ribonucleic acid levels and potentiates glucocorticoid hormone action.
Endocrinology 1993;132(6):2287-92.
1993: C B Whorwood; PC Barber; J Gregory; Michael C Sheppard; Paul M Stewart
11 beta-hydroxysteroid dehydrogenase and corticosteroid hormone receptors in the rat colon.
The American journal of physiology 1993;264(6 Pt 1):E951-7.
1993: Paul M Stewart
Reproduction and the shuttle.
Clinical endocrinology 1993;38(6):645-6.
1993: D Jenkins; Paul M Stewart
Advances in medical therapy for pituitary disease: treating patients with growth hormone excess and deficiency.
Journal of clinical pharmacy and therapeutics 1993;18(3):155-63.
1993: Paul M Stewart; R Penn; Roger L Holder; A Parton; J G Ratcliffe; D R London
The hypothalamo-pituitary-adrenal axis across the normal menstrual cycle and in polycystic ovary syndrome.
Clinical endocrinology 1993;38(4):387-91.
1993: Paul M Stewart; C B Whorwood; R Valentino; D Burt; Michael C Sheppard; C R Edwards
11-beta-hydroxysteroid dehydrogenase activity and gene expression in the hypertensive Bianchi-Milan rat.
Journal of hypertension 1993;11(4):349-54.
1993: Paul M Stewart; P Burra; C H Shackleton; Michael C Sheppard; Elwyn Elias
11 beta-Hydroxysteroid dehydrogenase deficiency and glucocorticoid status in patients with alcoholic and non-alcoholic chronic liver disease.
The Journal of clinical endocrinology and metabolism 1993;76(3):748-51.
1992: Paul M Stewart; M P Carey; C T Graham; A D Wright; D R London
Growth hormone secreting pituitary carcinoma: a case report and literature review.
Clinical endocrinology 1992;37(2):189-94.
1992: Paul M Stewart; P Venn; D A Heath; G Holder
Cyclical Cushing's syndrome.
British journal of hospital medicine 1992;48(3-4):186-7.
1992: Paul M Stewart; R Penn; R Gibson; Roger L Holder; A Parton; J G Ratcliffe; D R London
Hypothalamic abnormalities in patients with pituitary-dependent Cushing's syndrome.
Clinical endocrinology 1992;36(5):453-8.
1992: Paul M Stewart; Michael C Sheppard
Novel aspects of hormone action: intracellular ligand supply and its control by a series of tissue specific enzymes.
Molecular and cellular endocrinology 1992;83(2-3):C13-8.
1992: C B Whorwood; Jayne A Franklyn; Michael C Sheppard; Paul M Stewart
Tissue localization of 11 beta-hydroxysteroid dehydrogenase and its relationship to the glucocorticoid receptor.
The Journal of steroid biochemistry and molecular biology 1992;41(1):21-8.
1991: C R Edwards; Paul M Stewart
The cortisol-cortisone shuttle and the apparent specificity of glucocorticoid and mineralocorticoid receptors.
The Journal of steroid biochemistry and molecular biology 1991;39(5B):859-65.
1991: Paul M Stewart; C B Whorwood; P Barber; J Gregory; C Monder; Jayne A Franklyn; Michael C Sheppard
Localization of renal 11 beta-dehydrogenase by in situ hybridization: autocrine not paracrine protector of the mineralocorticoid receptor.
Endocrinology 1991;128(4):2129-35.
1990: Paul M Stewart; C H Shackleton; G H Beastall; C R Edwards
5 alpha-reductase activity in polycystic ovary syndrome.
Lancet 1990;335(8687):431-3.
1990: Paul M Stewart; A M Wallace; S M Atherden; C H Shearing; C R Edwards
Mineralocorticoid activity of carbenoxolone: contrasting effects of carbenoxolone and liquorice on 11 beta-hydroxysteroid dehydrogenase activity in man.
Clinical science (London, England : 1979) 1990;78(1):49-54.
1989: Paul M Stewart; M A McIntyre; C R Edwards
The endocrinopathy of POEMS syndrome.
Scottish medical journal 1989;34(5):520-2.
1989: J A Whitworth; Paul M Stewart; D Burt; S M Atherden; C R Edwards
The kidney is the major site of cortisone production in man.
Clinical endocrinology 1989;31(3):355-61.
1989: C Monder; Paul M Stewart; V Lakshmi; R Valentino; D Burt; C R Edwards
Licorice inhibits corticosteroid 11 beta-dehydrogenase of rat kidney and liver: in vivo and in vitro studies.
Endocrinology 1989;125(2):1046-53.
1989: Paul M Stewart; C R Edwards
The medical treatment of adrenal disease.
British journal of hospital medicine 1989;42(1):20-9.
1989: C R Edwards; D Burt; Paul M Stewart
The specificity of the human mineralocorticoid receptor: clinical clues to a biological conundrum.
Journal of steroid biochemistry 1989;32(1B):213-6.
1988: C R Edwards; Paul M Stewart; D Burt; L Brett; M A McIntyre; W S Sutanto; Ron de Kloet; C Monder
Localisation of 11 beta-hydroxysteroid dehydrogenase--tissue specific protector of the mineralocorticoid receptor.
Lancet 1988;2(8618):986-9.
1988: Paul M Stewart; S M Atherden; S E Stewart; L Whalley; C R Edwards; P L Padfield
Lithium carbonate--a competitive aldosterone antagonist?
The British journal of psychiatry : the journal of mental science 1988;153():205-7.
1988: Paul M Stewart; J E Corrie; C H Shackleton; C R Edwards
Syndrome of apparent mineralocorticoid excess. A defect in the cortisol-cortisone shuttle.
The Journal of clinical investigation 1988;82(1):340-9.
1988: Paul M Stewart; J Corrie; J R Seckl; C R Edwards; P L Padfield
A rational approach for assessing the hypothalamo-pituitary-adrenal axis.
Lancet 1988;1(8596):1208-10.
1987: Paul M Stewart; A M Wallace; R Valentino; D Burt; C H Shackleton; C R Edwards
Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of age.
Lancet 1987;2(8563):821-4.
1987: Paul M Stewart; J Grieve; I M Nairn; P L Padfield; C R Edwards
Lithium inhibits the action of fludrocortisone on the kidney.
Clinical endocrinology 1987;27(1):63-8.