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Sherman Stinson

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Humcha K Hariprakasha; Teresa Kosakowska-Cholody; Colin Meyer; Wieslaw Cholody; Sherman F Stinson; Nadya I Tarasova; Christopher J Michejda
Optimization of naphthalimide-imidazoacridone with potent antitumor activity leading to clinical candidate (HKH40A, RTA 502).
Eileen Brantley; Smitha Antony; Glenda Kohlhagen; Linghua Meng; Keli Agama; Sherman F Stinson; Edward A Sausville; Yves Pommier
Anti-tumor drug candidate 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole induces single-strand breaks and DNA-protein cross-links in sensitive MCF-7 breast cancer cells.
Gurmeet Kaur; Ven L Narayanan; Prabhakar A Risbood; Melinda G Hollingshead; Sherman F Stinson; Ravi K Varma; Edward A Sausville
Synthesis, structure-activity relationship, and p210(bcr-abl) protein tyrosine kinase activity of novel AG 957 analogs.

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2007: Humcha K Hariprakasha; Teresa Kosakowska-Cholody; Colin Meyer; Wieslaw Cholody; Sherman F Stinson; Nadya I Tarasova; Christopher J Michejda
Optimization of naphthalimide-imidazoacridone with potent antitumor activity leading to clinical candidate (HKH40A, RTA 502).
Journal of medicinal chemistry 2007;50(23):5557-60.
2006: Eileen Brantley; Smitha Antony; Glenda Kohlhagen; Linghua Meng; Keli Agama; Sherman F Stinson; Edward A Sausville; Yves Pommier
Anti-tumor drug candidate 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole induces single-strand breaks and DNA-protein cross-links in sensitive MCF-7 breast cancer cells.
Cancer chemotherapy and pharmacology 2006;58(1):62-72.
2005: Gurmeet Kaur; Ven L Narayanan; Prabhakar A Risbood; Melinda G Hollingshead; Sherman F Stinson; Ravi K Varma; Edward A Sausville
Synthesis, structure-activity relationship, and p210(bcr-abl) protein tyrosine kinase activity of novel AG 957 analogs.
Bioorganic & medicinal chemistry 2005;13(5):1749-61.
2005: Eileen Brantley; Vyomesh Patel; Sherman F Stinson; Valentina Trapani; Curtis Hose; Henry P Ciolino; Grace Chao Yeh; J Silvio Gutkind; Edward A Sausville; Andrea I Loaiza-Pérez
The antitumor drug candidate 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole induces NF-kappaB activity in drug-sensitive MCF-7 cells.
Anti-cancer drugs 2005;16(2):137-43.
2004: Eileen Brantley; Valentina Trapani; Michael C Alley; Curtis Hose; Tracey D Bradshaw; Malcolm F G Stevens; Edward A Sausville; Sherman F Stinson
Fluorinated 2-(4-amino-3-methylphenyl)benzothiazoles induce CYP1A1 expression, become metabolized, and bind to macromolecules in sensitive human cancer cells.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(12):1392-401.
2004: Richard B Greenwald; Hong Zhao; Jing Xia; Dechun Wu; Stephen Nervi; Sherman F Stinson; Eva Majerova; Chris Bramhall; Daniel W Zaharevitz
Poly(ethylene glycol) prodrugs of the CDK inhibitor, alsterpaullone (NSC 705701): synthesis and pharmacokinetic studies.
Bioconjugate chemistry 2004;15(5):1076-83.
2004: Angelika Burger; Heinz-Herbert Fiebig; Sherman F Stinson; Edward A Sausville
17-(Allylamino)-17-demethoxygeldanamycin activity in human melanoma models.
Anti-cancer drugs 2004;15(4):377-87.
2003: MICHELLE RUDEK-RENAUT; Kenneth S. Bauer; Richard M Lush; Sherman F Stinson; Adrian M Senderowicz; Donna Headlee; Arbuck Susan; Michael C Cox; Anthony J Murgo; Edward A Sausville; William D Figg
Clinical pharmacology of flavopiridol following a 72-hour continuous infusion.
The Annals of pharmacotherapy 2003;37(10):1369-74.
2002: Sherman F Stinson; TL House; Chris Bramhall; Joseph E Saavedra; Larry K Keefer; Raymond W Nims
Plasma pharmacokinetics of a liver-selective nitric oxide-donating diazeniumdiolate in the male C57BL/6 mouse.
Xenobiotica; the fate of foreign compounds in biological systems 2002;32(4):339-47.
2002: Lawrence R Phillip; Jean L Jorden; Maria I Rivera; Tracy L Wolfe; Kaye Upadhyayb; Sherman F Stinson
Identification of the major metabolite of 2,5-bis(5-hydroxymethyl-2-thienyl)furan (NSC 652287), an antitumor agent, in the S9 subcellular fraction of dog liver cells.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2002;767(1):27-33.
2002: Tracey D Bradshaw; Michael C Bibby; John A Double; Iduna Fichtner; Patricia A Cooper; Michael C Alley; Susan Donohue; Sherman F Stinson; Joseph E Tomaszewjski; Edward A Sausville; Malcolm F G Stevens
Preclinical evaluation of amino acid prodrugs of novel antitumor 2-(4-amino-3-methylphenyl)benzothiazoles.
Molecular cancer therapeutics 2002;1(4):239-46.
2000: MS Chua; E Kashiyama; Tracey D Bradshaw; Sherman F Stinson; Eileen Brantley; Edward A Sausville; Malcolm F G Stevens
Role of Cyp1A1 in modulation of antitumor properties of the novel agent 2-(4-amino-3-methylphenyl)benzothiazole (DF 203, NSC 674495) in human breast cancer cells.
Cancer research 2000;60(18):5196-203.
2000: LR Phillips; Chris Bramhall; J Buckley; T Wolfe; TL House; Sherman F Stinson
Identification of the principal circulating metabolite of a synthetic 5,4'-diaminoflavone (NSC 686288), an antitumor agent, in the rat.
Journal of chromatography. B, Biomedical sciences and applications 2000;741(2):205-11.
1999: E Kashiyama; Ian Hutchinson; MS Chua; Sherman F Stinson; LR Phillips; G Kaur; Edward A Sausville; Tracey D Bradshaw; Andrew D Westwell; Malcolm F G Stevens
Antitumor benzothiazoles. 8. Synthesis, metabolic formation, and biological properties of the C- and N-oxidation products of antitumor 2-(4-aminophenyl)benzothiazoles.
Journal of medicinal chemistry 1999;42(20):4172-84.
1999: LR Phillips; Chris Bramhall; J Buckley; T W Daw; Sherman F Stinson
Analysis of 2-(3-methyl-4-aminophenyl)-benzothiazole (NSC 674495) in plasma by gas chromatography with mass-selective detection.
Journal of chromatography. B, Biomedical sciences and applications 1999;732(2):315-21.
1999: Joachim B Schnier; Gurmeet Kaur; A Kaiser; Sherman F Stinson; Edward A Sausville; J Gardner; Kayoko Nishi; E Morton Bradbury; A M Senderowicz
Identification of cytosolic aldehyde dehydrogenase 1 from non-small cell lung carcinomas as a flavopiridol-binding protein.
FEBS letters 1999;454(1-2):100-4.
1999: M I Rivera; Sherman F Stinson; David T Vistica; Jean L Jorden; S Kenney; Edward A Sausville
Selective toxicity of the tricyclic thiophene NSC 652287 in renal carcinoma cell lines: differential accumulation and metabolism.
Biochemical pharmacology 1999;57(11):1283-95.
1999: Edward A Sausville; Daniel W Zaharevitz; Rick Gussio; Laurent Meijer; M Louarn-Leost; Conrad Kunick; R Schultz; Tyler Lahusen; Donna Headlee; Sherman F Stinson; Arbuck Susan; Adrian M Senderowicz
Cyclin-dependent kinases: initial approaches to exploit a novel therapeutic target.
Pharmacology & therapeutics 1999;82(2-3):285-92.
1998: R S Randad; L Lubkowska; M A Eissenstat; Sergei V Gulnik; B Yu; TN Bhat; D J Clanton; TL House; Sherman F Stinson; John W Erickson
Unsymmetric nonpeptidic HIV protease inhibitors containing anthranilamide as a P2' ligand.
Bioorganic & medicinal chemistry letters 1998;8(24):3537-42.
1998: Adrian M Senderowicz; Donna Headlee; Sherman F Stinson; Richard M Lush; N Kalil; L Villalba; K Hill; Seth M Steinberg; William D Figg; AC Tompkins; Arbuck Susan; Edward A Sausville
Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998;16(9):2986-99.
1998: Francisco Arguello; M Alexander; J A Sterry; G Tudor; E M Smith; N T Kalavar; John F Greene; W Koss; CD Morgan; Sherman F Stinson; T J Siford; W Gregory Alvord; Richard L Klabansky; Edward A Sausville
Flavopiridol induces apoptosis of normal lymphoid cells, causes immunosuppression, and has potent antitumor activity In vivo against human leukemia and lymphoma xenografts.
Blood 1998;91(7):2482-90.
1998: Sherman F Stinson; K Hill; T J Siford; LR Phillips; T W Daw
Determination of flavopiridol (L86 8275; NSC 649890) in human plasma by reversed-phase liquid chromatography with electrochemical detection.
Cancer chemotherapy and pharmacology 1998;42(4):261-5.
1998: Francisco Arguello; M A Alexander; John F Greene; Sherman F Stinson; Jean L Jorden; E M Smith; N T Kalavar; W G Alvord; Richard L Klabansky; Edward A Sausville
Preclinical evaluation of 9-chloro-2-methylellipticinium acetate alone and in combination with conventional anticancer drugs for the treatment of human brain tumor xenografts.
Journal of cancer research and clinical oncology 1998;124(1):19-26.