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Martha Stipanuk

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Iori Ueki; Lawrence L Hirschberger; Carolyn Junior; Heather B Roman; Martha H Stipanuk
Extrahepatic tissues compensate for loss of hepatic taurine synthesis in mice with liver-specific knockout of cysteine dioxygenase.
Benedetta Bartali; Stefania Bandinelli; Edward A Frongillo; Jack M Guralnik; Jose A Morais; Domenico Palli; Simonetta Salvini; Martha H Stipanuk; Stefano Volpato; Luigi Ferrucci
Protein intake and muscle strength in older persons: does inflammation matter?
Iori Ueki; Alessandro Valli; Krista Fieselmann; Lawrence L Hirschberger; Jimmy Lam; Rachel Peters; Heather B Roman; Martha H Stipanuk
Knockout of the murine cysteine dioxygenase gene results in severe impairment in ability to synthesize taurine and an increased catabolism of cysteine to hydrogen sulfide.

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All Publications

2012: Iori Ueki; Lawrence L Hirschberger; Carolyn Junior; Heather B Roman; Martha H Stipanuk
Extrahepatic tissues compensate for loss of hepatic taurine synthesis in mice with liver-specific knockout of cysteine dioxygenase.
American journal of physiology. Endocrinology and metabolism 2012;302(10):E1292-9.
2012: Benedetta Bartali; Stefania Bandinelli; Edward A Frongillo; Jack M Guralnik; Jose A Morais; Domenico Palli; Simonetta Salvini; Martha H Stipanuk; Stefano Volpato; Luigi Ferrucci
Protein intake and muscle strength in older persons: does inflammation matter?
Journal of the American Geriatrics Society 2012;60(3):480-4.
2011: Iori Ueki; Alessandro Valli; Krista Fieselmann; Lawrence L Hirschberger; Jimmy Lam; Rachel Peters; Heather B Roman; Martha H Stipanuk
Knockout of the murine cysteine dioxygenase gene results in severe impairment in ability to synthesize taurine and an increased catabolism of cysteine to hydrogen sulfide.
American journal of physiology. Endocrinology and metabolism 2011;301(4):E668-84.
2011: Maria Wróbel; Martha H Stipanuk; Noriuki Nagahara
Sulfur- and seleno-containing amino acids.
Amino acids 2011;41(1):1-2.
2011: Angelos K Sikalidis; Jeong-In Lee; Martha H Stipanuk
Gene expression and integrated stress response in HepG2/C3A cells cultured in amino acid deficient medium.
Amino acids 2011;41(1):159-71.
2011: Martha H Stipanuk; Chad R Simmons; P Andrew Karplus; John Dominy
Thiol dioxygenases: unique families of cupin proteins.
Amino acids 2011;41(1):91-102.
2011: Martha H Stipanuk; Iori Ueki
Dealing with methionine/homocysteine sulfur: cysteine metabolism to taurine and inorganic sulfur.
Journal of inherited metabolic disease 2011;34(1):17-32.
2010: Angelos K Sikalidis; Martha H Stipanuk
Growing rats respond to a sulfur amino acid-deficient diet by phosphorylation of the alpha subunit of eukaryotic initiation factor 2 heterotrimeric complex and induction of adaptive components of the integrated stress response.
The Journal of nutrition 2010;140(6):1080-5.
2009: Martha H Stipanuk
Macroautophagy and its role in nutrient homeostasis.
Nutrition reviews 2009;67(12):677-89.
2009: Martha H Stipanuk; Iori Ueki; John Dominy; Chad R Simmons; Lawrence L Hirschberger
Cysteine dioxygenase: a robust system for regulation of cellular cysteine levels.
Amino acids 2009;37(1):55-63.
2009: Iori Ueki; Martha H Stipanuk
3T3-L1 adipocytes and rat adipose tissue have a high capacity for taurine synthesis by the cysteine dioxygenase/cysteinesulfinate decarboxylase and cysteamine dioxygenase pathways.
The Journal of nutrition 2009;139(2):207-14.
2008: Chad R Simmons; Kalyanaraman Krishnamoorthy; Spencer L Granett; David J Schuller; John E Dominy; Tadhg P Begley; Martha H Stipanuk; P Andrew Karplus
A putative Fe2+-bound persulfenate intermediate in cysteine dioxygenase.
Biochemistry 2008;47(44):11390-2.
2008: John Dominy; Jesse Hwang; Stephanie Guo; Lawrence L Hirschberger; Sheng Zhang; Martha H Stipanuk
Synthesis of amino acid cofactor in cysteine dioxygenase is regulated by substrate and represents a novel post-translational regulation of activity.
The Journal of biological chemistry 2008;283(18):12188-201.
2008: Jeong-In Lee; John Dominy; Angelos K Sikalidis; Lawrence L Hirschberger; Wei Wang; Martha H Stipanuk
HepG2/C3A cells respond to cysteine deprivation by induction of the amino acid deprivation/integrated stress response pathway.
Physiological genomics 2008;33(2):218-29.
2008: Benedetta Bartali; Edward A Frongillo; Jack M Guralnik; Martha H Stipanuk; Heather G Allore; Antonio Cherubini; Stefania Bandinelli; Luigi Ferrucci; Thomas M Gill
Serum micronutrient concentrations and decline in physical function among older persons.
JAMA : the journal of the American Medical Association 2008;299(3):308-15.
2007: John Dominy; Chad R Simmons; Lawrence L Hirschberger; Jesse Hwang; Relicardo M Coloso; Martha H Stipanuk
Discovery and characterization of a second mammalian thiol dioxygenase, cysteamine dioxygenase.
The Journal of biological chemistry 2007;282(35):25189-98.
2007: Iori Ueki; Martha H Stipanuk
Enzymes of the taurine biosynthetic pathway are expressed in rat mammary gland.
The Journal of nutrition 2007;137(8):1887-94.
2007: Martha H Stipanuk
The keto acid of methionine is a safe and efficacious substitute for dietary L-methionine: the answer from chick bioassays.
The Journal of nutrition 2007;137(8):1844-5.
2007: John Dominy; Jesse Hwang; Martha H Stipanuk
Overexpression of cysteine dioxygenase reduces intracellular cysteine and glutathione pools in HepG2/C3A cells.
American journal of physiology. Endocrinology and metabolism 2007;293(1):E62-9.
2007: Martha H Stipanuk
Leucine and protein synthesis: mTOR and beyond.
Nutrition reviews 2007;65(3):122-9.
2006: Kwang Suk Ko; Cristina L Tôrres; Andrea J Fascetti; Martha H Stipanuk; Lawrence L Hirschberger; Quinton R Rogers
Copper deficiency does not lead to taurine deficiency in rats.
The Journal of nutrition 2006;136(10):2502-5.
2006: John Dominy; Chad R Simmons; P Andrew Karplus; Amy M Gehring; Martha H Stipanuk
Identification and characterization of bacterial cysteine dioxygenases: a new route of cysteine degradation for eubacteria.
Journal of bacteriology 2006;188(15):5561-9.
2006: Chad R Simmons; Qun Liu; Qingqiu Huang; Quan Hao; Tadhg P Begley; P Andrew Karplus; Martha H Stipanuk
Crystal structure of mammalian cysteine dioxygenase. A novel mononuclear iron center for cysteine thiol oxidation.
The Journal of biological chemistry 2006;281(27):18723-33.
2006: Martha H Stipanuk; John Dominy; Jeong-In Lee; Relicardo M Coloso
Mammalian cysteine metabolism: new insights into regulation of cysteine metabolism.
The Journal of nutrition 2006;136(6 Suppl):1652S-1659S.
2006: Martha H Stipanuk; John Dominy
Surprising insights that aren't so surprising in the modeling of sulfur amino acid metabolism.
Amino acids 2006;30(3):251-6.
2006: Chad R Simmons; Lawrence L Hirschberger; Mari S Machi; Martha H Stipanuk
Expression, purification, and kinetic characterization of recombinant rat cysteine dioxygenase, a non-heme metalloenzyme necessary for regulation of cellular cysteine levels.
Protein expression and purification 2006;47(1):74-81.
2006: John Dominy; Lawrence L Hirschberger; Relicardo M Coloso; Martha H Stipanuk
Regulation of cysteine dioxygenase degradation is mediated by intracellular cysteine levels and the ubiquitin-26 S proteasome system in the living rat.
The Biochemical journal 2006;394(Pt 1):267-73.
2006: John Dominy; Lawrence L Hirschberger; Relicardo M Coloso; Martha H Stipanuk
In vivo regulation of cysteine dioxygenase via the ubiquitin-26S proteasome system.
Advances in experimental medicine and biology 2006;583():37-47.
2006: Relicardo M Coloso; Lawrence L Hirschberger; John Dominy; Jeong-In Lee; Martha H Stipanuk
Cysteamine dioxygenase: evidence for the physiological conversion of cysteamine to hypotaurine in rat and mouse tissues.
Advances in experimental medicine and biology 2006;583():25-36.
2006: Jeong-In Lee; Joann Kang; Martha H Stipanuk
Differential regulation of glutamate-cysteine ligase subunit expression and increased holoenzyme formation in response to cysteine deprivation.
The Biochemical journal 2006;393(Pt 1):181-90.
2005: Chad R Simmons; Quan Hao; Martha H Stipanuk
Preparation, crystallization and X-ray diffraction analysis to 1.5 A resolution of rat cysteine dioxygenase, a mononuclear iron enzyme responsible for cysteine thiol oxidation.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 11):1013-6.
2004: John Dominy; Martha H Stipanuk
New roles for cysteine and transsulfuration enzymes: production of H2S, a neuromodulator and smooth muscle relaxant.
Nutrition reviews 2004;62(9):348-53.
2004: Martha H Stipanuk; Lawrence L Hirschberger; Monica Londono; Carrie L Cresenzi; Anthony F Yu
The ubiquitin-proteasome system is responsible for cysteine-responsive regulation of cysteine dioxygenase concentration in liver.
American journal of physiology. Endocrinology and metabolism 2004;286(3):E439-48.
2004: Jeong-In Lee; Monica Londono; Lawrence L Hirschberger; Martha H Stipanuk
Regulation of cysteine dioxygenase and gamma-glutamylcysteine synthetase is associated with hepatic cysteine level.
The Journal of nutritional biochemistry 2004;15(2):112-22.
2004: Martha H Stipanuk; Monica Londono; Lawrence L Hirschberger; Christopher Hickey; D J Thiel; L Wang
Evidence for expression of a single distinct form of mammalian cysteine dioxygenase.
Amino acids 2004;26(1):99-106.
2004: Martha H Stipanuk
Sulfur amino acid metabolism: pathways for production and removal of homocysteine and cysteine.
Annual review of nutrition 2004;24():539-77.
2004: Martha H Stipanuk
Role of the liver in regulation of body cysteine and taurine levels: a brief review.
Neurochemical research 2004;29(1):105-10.
2003: Carrie L Cresenzi; Jeong-In Lee; Martha H Stipanuk
Cysteine is the metabolic signal responsible for dietary regulation of hepatic cysteine dioxygenase and glutamate cysteine ligase in intact rats.
The Journal of nutrition 2003;133(9):2697-702.
2002: Martha H Stipanuk; Monica Londono; Jeong-In Lee; Mindy Hu; Anthony F Yu
Enzymes and metabolites of cysteine metabolism in nonhepatic tissues of rats show little response to changes in dietary protein or sulfur amino acid levels.
The Journal of nutrition 2002;132(11):3369-78.
2002: DL Bella; Lawrence L Hirschberger; YH Kwon; Martha H Stipanuk
Cysteine metabolism in periportal and perivenous hepatocytes: perivenous cells have greater capacity for glutathione production and taurine synthesis but not for cysteine catabolism.
Amino acids 2002;23(4):453-8.
2001: Lawrence L Hirschberger; S Daval; Patrick J Stover; Martha H Stipanuk
Murine cysteine dioxygenase gene: structural organization, tissue-specific expression and promoter identification.
Gene 2001;277(1-2):153-61.
2001: YH Kwon; Martha H Stipanuk
Cysteine regulates expression of cysteine dioxygenase and gamma-glutamylcysteine synthetase in cultured rat hepatocytes.
American journal of physiology. Endocrinology and metabolism 2001;280(5):E804-15.
2000: DL Bella; YH Kwon; Lawrence L Hirschberger; Martha H Stipanuk
Post-transcriptional regulation of cysteine dioxygenase in rat liver.
Advances in experimental medicine and biology 2000;483():71-85.
1999: DL Bella; C Hahn; Martha H Stipanuk
Effects of nonsulfur and sulfur amino acids on the regulation of hepatic enzymes of cysteine metabolism.
The American journal of physiology 1999;277(1 Pt 1):E144-53.
1999: DL Bella; Lawrence L Hirschberger; Y Hosokawa; Martha H Stipanuk
Mechanisms involved in the regulation of key enzymes of cysteine metabolism in rat liver in vivo.
The American journal of physiology 1999;276(2 Pt 1):E326-35.
1996: DL Bella; Y H Kwon; Martha H Stipanuk
Variations in dietary protein but not in dietary fat plus cellulose or carbohydrate levels affect cysteine metabolism in rat isolated hepatocytes.
The Journal of nutrition 1996;126(9):2179-87.
1996: DL Bella; Martha H Stipanuk
High levels of dietary protein or methionine have different effects on cysteine metabolism in rat hepatocytes.
Advances in experimental medicine and biology 1996;403():73-84.
1996: J Ohta; Martha H Stipanuk
Taurine production in rat primary hepatocytes.
Advances in experimental medicine and biology 1996;403():69-71.
1995: DL Bella; Martha H Stipanuk
Effects of protein, methionine, or chloride on acid-base balance and on cysteine catabolism.
The American journal of physiology 1995;269(5 Pt 1):E910-7.
1995: P J Bagley; L L Hirschberger; Martha H Stipanuk
Evaluation and modification of an assay procedure for cysteine dioxygenase activity: high-performance liquid chromatography method for measurement of cysteine sulfinate and demonstration of physiological relevance of cysteine dioxygenase activity in cysteine catabolism.
Analytical biochemistry 1995;227(1):40-8.
1995: P J Bagley; Martha H Stipanuk
Rats fed a low protein diet supplemented with sulfur amino acids have increased cysteine dioxygenase activity and increased taurine production in hepatocytes.
The Journal of nutrition 1995;125(4):933-40.
1994: P J Bagley; Martha H Stipanuk
The activities of rat hepatic cysteine dioxygenase and cysteinesulfinate decarboxylase are regulated in a reciprocal manner in response to dietary casein level.
The Journal of nutrition 1994;124(12):2410-21.
1994: M F Banks; Martha H Stipanuk
The utilization of N-acetylcysteine and 2-oxothiazolidine-4-carboxylate by rat hepatocytes is limited by their rate of uptake and conversion to cysteine.
The Journal of nutrition 1994;124(3):378-87.
1994: Martha H Stipanuk; P J Bagley; Y C Hou; DL Bella; M F Banks; L L Hirschberger
Hepatic regulation of cysteine utilization for taurine synthesis.
Advances in experimental medicine and biology 1994;359():79-89.
1993: J L Ensunsa; L L Hirschberger; Martha H Stipanuk
Catabolism of cysteine, cystine, cysteinesulfinate, and OTC by isolated perfused rat hindquarter.
The American journal of physiology 1993;264(5 Pt 1):E782-9.
1992: R A Garcia; Martha H Stipanuk
The splanchnic organs, liver and kidney have unique roles in the metabolism of sulfur amino acids and their metabolites in rats.
The Journal of nutrition 1992;122(8):1693-701.
1992: Martha H Stipanuk; R M Coloso; R A Garcia; M F Banks
Cysteine concentration regulates cysteine metabolism to glutathione, sulfate and taurine in rat hepatocytes.
The Journal of nutrition 1992;122(3):420-7.
1992: Martha H Stipanuk; L L Hirschberger; P J Bagley
Anion-exchange HPLC of taurine, cysteinesulfinate and cysteic acid.
Advances in experimental medicine and biology 1992;315():429-35.
1992: Martha H Stipanuk; P J Bagley; R M Coloso; M F Banks
Metabolism of cysteine to taurine by rat hepatocytes.
Advances in experimental medicine and biology 1992;315():413-21.
1991: R M Coloso; L L Hirschberger; Martha H Stipanuk
Uptake and metabolism of L-2-oxo-[35S]thiazolidine-4-carboxylate by rat cells is slower than that of L-[35S]cysteine or L-[35S]methionine.
The Journal of nutrition 1991;121(9):1341-8.
1991: N S Moise; L M Pacioretty; Francis A Kallfelz; Martha H Stipanuk; J M King; Robert F Gilmour
Dietary taurine deficiency and dilated cardiomyopathy in the fox.
American heart journal 1991;121(2 Pt 1):541-7.
1990: R M Coloso; M R Drake; Martha H Stipanuk
Effect of bathocuproine disulfonate, a copper chelator, on cyst(e)ine metabolism by freshly isolated rat hepatocytes.
The American journal of physiology 1990;259(3 Pt 1):E443-50.
1990: A M Rao; M R Drake; Martha H Stipanuk
Role of the transsulfuration pathway and of gamma-cystathionase activity in the formation of cysteine and sulfate from methionine in rat hepatocytes.
The Journal of nutrition 1990;120(8):837-45.
1990: Martha H Stipanuk; J De la Rosa; L L Hirschberger
Catabolism of cyst(e)ine by rat renal cortical tubules.
The Journal of nutrition 1990;120(5):450-8.
1989: R M Coloso; Martha H Stipanuk
Metabolism of cyst(e)ine in rat enterocytes.
The Journal of nutrition 1989;119(12):1914-24.
1988: R A Garcia; L L Hirschberger; Martha H Stipanuk
Measurement of cyst(e)amine in physiological samples by high performance liquid chromatography.
Analytical biochemistry 1988;170(2):432-40.
1987: M R Drake; J De La Rosa; Martha H Stipanuk
Metabolism of cysteine in rat hepatocytes. Evidence for cysteinesulphinate-independent pathways.
The Biochemical journal 1987;244(2):279-86.
1987: J de la Rosa; M R Drake; Martha H Stipanuk
Metabolism of cysteine and cysteinesulfinate in rat and cat hepatocytes.
The Journal of nutrition 1987;117(3):549-58.
1987: Martha H Stipanuk; L L Hirschberger; J De la Rosa
Cysteinesulfinic acid, hypotaurine, and taurine: reversed-phase high-performance liquid chromatography.
Methods in enzymology 1987;143():155-60.
1986: L A Rentschler; L L Hirschberger; Martha H Stipanuk
Response of the kitten to dietary taurine depletion: effects on renal reabsorption, bile acid conjugation and activities of enzymes involved in taurine synthesis.
Comparative biochemistry and physiology. B, Comparative biochemistry 1986;84(3):319-25.
1985: L L Hirschberger; J De La Rosa; Martha H Stipanuk
Determination of cysteinesulfinate, hypotaurine and taurine in physiological samples by reversed-phase high-performance liquid chromatography.
Journal of chromatography 1985;343(2):303-13.
1985: J De la Rosa; Martha H Stipanuk
The effect of taurine depletion with guanidinoethanesulfonate on bile acid metabolism in the rat.
Life sciences 1985;36(14):1347-51.
1985: J de la Rosa; Martha H Stipanuk
Evidence for a rate-limiting role of cysteinesulfinate decarboxylase activity in taurine biosynthesis in vivo.
Comparative biochemistry and physiology. B, Comparative biochemistry 1985;81(3):565-71.
1984: Martha H Stipanuk; S M Kuo; L L Hirschberger
Changes in maternal taurine levels in response to pregnancy and lactation.
Life sciences 1984;35(11):1149-55.
1984: S M Kuo; Martha H Stipanuk
Changes in cysteine dioxygenase and cysteinesulfinate decarboxylase activities and taurine levels in tissues of pregnant or lactating rat dams and their fetuses or pups.
Biology of the neonate 1984;46(5):237-48.
1983: S M Kuo; T C Lea; Martha H Stipanuk
Developmental pattern, tissue distribution, and subcellular distribution of cysteine: alpha-ketoglutarate aminotransferase and 3-mercaptopyruvate sulfurtransferase activities in the rat.
Biology of the neonate 1983;43(1-2):23-32.