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Alan Stobie

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Chemicals & Drugs

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Publications

TOP 3
Patrick S Johnson; Mark Lewis; Helen J Mason; James Mills; Julie Newman; Christelle Pasquinet; Dave J Rawson; Lee R Roberts; Rachel Russell; Thomas Ryckmans; Deborah Spark; Alan Stobie; Toby J Underwood; Robin Ward; Dave M Beal; Justin Bryans; Kevin Dack; Neil Feeder; Anthony Harrison; Simon Wheeler
Discovery of PF-184563, a potent and selective V1a antagonist for the treatment of dysmenorrhoea. The influence of compound flexibility on microsomal stability.
M Jonathan Fray; Paul V Fish; Gillian A Allan; Gerwyn Bish; Nick Clarke; Rachel Eccles; Anthony C Harrison; Jean-Loic Le Net; Stephen C Phillips; Nicola Regan; Cecile Sobry; Alan Stobie; Florian Wakenhut; Dominique Westbrook; Simon L Westbrook; Gavin A Whitlock
Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reducing ion channel activity.
Florian Wakenhut; Gill A Allan; Paul V Fish; M Jonathan Fray; Anthony C Harrison; Rachel McCoy; Stephen C Phillips; Thomas Ryckmans; Alan Stobie; Dominique Westbrook; Simon L Westbrook; Gavin A Whitlock
N-[(3S)-Pyrrolidin-3-yl]benzamides as novel dual serotonin and noradrenaline reuptake inhibitors: impact of small structural modifications on P-gp recognition and CNS penetration.

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All Publications

2011: Patrick S Johnson; Mark Lewis; Helen J Mason; James Mills; Julie Newman; Christelle Pasquinet; Dave J Rawson; Lee R Roberts; Rachel Russell; Thomas Ryckmans; Deborah Spark; Alan Stobie; Toby J Underwood; Robin Ward; Dave M Beal; Justin Bryans; Kevin Dack; Neil Feeder; Anthony Harrison; Simon Wheeler
Discovery of PF-184563, a potent and selective V1a antagonist for the treatment of dysmenorrhoea. The influence of compound flexibility on microsomal stability.
Bioorganic & medicinal chemistry letters 2011;21(19):5684-7.
2010: M Jonathan Fray; Paul V Fish; Gillian A Allan; Gerwyn Bish; Nick Clarke; Rachel Eccles; Anthony C Harrison; Jean-Loic Le Net; Stephen C Phillips; Nicola Regan; Cecile Sobry; Alan Stobie; Florian Wakenhut; Dominique Westbrook; Simon L Westbrook; Gavin A Whitlock
Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reducing ion channel activity.
Bioorganic & medicinal chemistry letters 2010;20(12):3788-92.
2009: Florian Wakenhut; Gill A Allan; Paul V Fish; M Jonathan Fray; Anthony C Harrison; Rachel McCoy; Stephen C Phillips; Thomas Ryckmans; Alan Stobie; Dominique Westbrook; Simon L Westbrook; Gavin A Whitlock
N-[(3S)-Pyrrolidin-3-yl]benzamides as novel dual serotonin and noradrenaline reuptake inhibitors: impact of small structural modifications on P-gp recognition and CNS penetration.
Bioorganic & medicinal chemistry letters 2009;19(17):5078-81.
2009: Paul V Fish; Florian Wakenhut; Thomas Ryckmans; Alan Stobie
Design, synthesis and evaluation of N-[(3S)-pyrrolidin-3-yl]benzamides as selective noradrenaline reuptake inhibitors: CNS penetration in a more polar template.
Bioorganic & medicinal chemistry letters 2009;19(16):4579-83.
2009: Paul V Fish; Mark D Andrews; M Jonathan Fray; Alan Stobie; Florian Wakenhut; Gavin A Whitlock
4-Piperidines and 3-pyrrolidines as dual serotonin and noradrenaline reuptake inhibitors: design, synthesis and structure-activity relationships.
Bioorganic & medicinal chemistry letters 2009;19(10):2829-34.
2008: Florian Wakenhut; Paul V Fish; M Jonathan Fray; Ian Gurrell; James E Mills; Alan Stobie; Gavin A Whitlock
N-Benzyl-N-(pyrrolidin-3-yl)carboxamides as a new class of selective dual serotonin/noradrenaline reuptake inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(15):4308-11.
2008: Paul V Fish; Nancy S Barta; David L F Gray; Thomas Ryckmans; Alan Stobie; Florian Wakenhut; Gavin A Whitlock
Derivatives of (3S)-N-(biphenyl-2-ylmethyl)pyrrolidin-3-amine as selective noradrenaline reuptake inhibitors: Reducing P-gp mediated efflux by modulation of H-bond acceptor capacity.
Bioorganic & medicinal chemistry letters 2008;18(15):4355-9.
2008: Donald S Middleton; Mark Andrews; Paul Glossop; Geoffrey Gymer; David Hepworth; Alan Jessiman; Patrick S Johnson; Malcolm Mackenny; Michael J Pitcher; Tony Rooker; Alan Stobie; Kim Tang; Paul Morgan
Designing rapid onset selective serotonin re-uptake inhibitors. 2: structure-activity relationships of substituted (aryl)benzylamines.
Bioorganic & medicinal chemistry letters 2008;18(14):4018-21.
2007: Paul V Fish; M Jonathan Fray; Alan Stobie; Florian Wakenhut; Gavin A Whitlock
N-Benzyl-N-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-amines as selective dual serotonin/noradrenaline reuptake inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(7):2022-5.
2007: David C Pryde; Andrew S Cook; Denise J Burring; Lyn H Jones; Stephanie Foll; Michelle Y Platts; Vivienne Sanderson; Martin Corless; Alan Stobie; Donald S Middleton; Laura Foster; Laura Barker; Piet Van Der Graaf; Peter Stacey; Christopher Kohl; Sara Coggon; Kevin Beaumont
Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder.
Bioorganic & medicinal chemistry 2007;15(1):142-59.
2006: M Jonathan Fray; Gerwyn Bish; Paul V Fish; Alan Stobie; Florian Wakenhut; Gavin A Whitlock
Structure-activity relationships of N-substituted piperazine amine reuptake inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(16):4349-53.
2006: M Jonathan Fray; Gerwyn Bish; Alan D Brown; Paul V Fish; Alan Stobie; Florian Wakenhut; Gavin A Whitlock
N-(1,2-diphenylethyl)piperazines: a new class of dual serotonin/noradrenaline reuptake inhibitor.
Bioorganic & medicinal chemistry letters 2006;16(16):4345-8.
2006: David C Pryde; Graham N Maw; Simon Planken; Michelle Y Platts; Vivienne Sanderson; Martin Corless; Alan Stobie; Christopher G Barber; Rachel Russell; Laura Foster; Laura Barker; Christopher Wayman; Piet Van Der Graaf; Peter Stacey; Debbie Morren; Christopher Kohl; Kevin Beaumont; Sara Coggon; Michael Tute
Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder. Synthesis and activity of functionalized glutaramides.
Journal of medicinal chemistry 2006;49(14):4409-24.
2006: Donald S Middleton; Mark Andrews; Paul Glossop; Geoffrey Gymer; Alan Jessiman; Patrick S Johnson; Malcolm Mackenny; Michael J Pitcher; Tony Rooker; Alan Stobie; Kim Tang; Paul Morgan
Designing rapid onset selective serotonin re-uptake inhibitors. Part 1: Structure-activity relationships of substituted (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydro-1-naphthaleneamine.
Bioorganic & medicinal chemistry letters 2006;16(5):1434-9.
2006: Graham N Maw; Alan Stobie; Simon Planken; David C Pryde; Vivienne Sanderson; Michelle Y Platts; Martin Corless; Peter Stacey; Christopher Wayman; Piet Van Der Graaf; Christopher Kohl; Sara Coggon; Kevin Beaumont
The discovery of small molecule inhibitors of neutral endopeptidase. Structure-activity studies on functionalized glutaramides.
Chemical biology & drug design 2006;67(1):74-7.
2001: M Jonathan Fray; D J Bull; C L Carr; E C Gautier; C E Mowbray; Alan Stobie
Structure-activity relationships of 1,4-dihydro-(1H,4H)-quinoxaline-2,3-diones as N-methyl-D-aspartate (glycine site) receptor antagonists. 1. Heterocyclic substituted 5-alkyl derivatives.
Journal of medicinal chemistry 2001;44(12):1951-62.