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Paul Stocks

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Louise La Pensée; Sunil Sabbani; Raman Sharma; Emma Shore; Paul A Stocks; Stephen A Ward; Yi Hang Wu; Nuna C Araujo; Cerys Bateman; Neil G Berry; Inder Bhamra; Lília Cabral; Amy E Chadwick; Richard Cosstick; M Lurdes S Cristiano; James Firman; Adelina Gavrila; Afthab Hussain; Omar Janneh; Paul M O'Neill
Artemisinin-polypyrrole conjugates: synthesis, DNA binding studies and preliminary antiproliferative evaluation.
Suet C Leung; Alison Mbekeani; Gemma L Nixon; Richard Amewu; Olivier Berger; Neil G Berry; Giancarlo A Biagini; Sitthivut Charoensutthivarakul; Nicholas E Fisher; Peter Gibbons; Alasdair Hill; W David Hong; Bénédicte Pacorel; Chandrakala Pidathala; Raman Sharma; Alison E Shone; Abhishek Srivastava; Paul A Stocks; Lee Taylor; Stephen A Ward; Ashley J Warman; Paul M O'Neill
Identification, design and biological evaluation of heterocyclic quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).
Chandrakala Pidathala; Raman Sharma; Alison E Shone; Abhishek Srivastava; Paul A Stocks; Lee Taylor; Stephen A Ward; Ashley J Warman; Richard Amewu; Olivier Berger; Neil G Berry; Giancarlo A Biagini; Sitthivut Charoensutthivarakul; Nicholas E Fisher; Peter Gibbons; Alasdair Hill; W David Hong; Suet C Leung; Alison Mbekeani; Gemma L Nixon; Bénédicte Pacorel; Paul M O'Neill
Identification, design and biological evaluation of bisaryl quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).

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All Publications

2013: Louise La Pensée; Sunil Sabbani; Raman Sharma; Emma Shore; Paul A Stocks; Stephen A Ward; Yi Hang Wu; Nuna C Araujo; Cerys Bateman; Neil G Berry; Inder Bhamra; Lília Cabral; Amy E Chadwick; Richard Cosstick; M Lurdes S Cristiano; James Firman; Adelina Gavrila; Afthab Hussain; Omar Janneh; Paul M O'Neill
Artemisinin-polypyrrole conjugates: synthesis, DNA binding studies and preliminary antiproliferative evaluation.
ChemMedChem 2013;8(5):709-18.
2012: Suet C Leung; Alison Mbekeani; Gemma L Nixon; Richard Amewu; Olivier Berger; Neil G Berry; Giancarlo A Biagini; Sitthivut Charoensutthivarakul; Nicholas E Fisher; Peter Gibbons; Alasdair Hill; W David Hong; Bénédicte Pacorel; Chandrakala Pidathala; Raman Sharma; Alison E Shone; Abhishek Srivastava; Paul A Stocks; Lee Taylor; Stephen A Ward; Ashley J Warman; Paul M O'Neill
Identification, design and biological evaluation of heterocyclic quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).
Journal of medicinal chemistry 2012;55(5):1844-57.
2012: Chandrakala Pidathala; Raman Sharma; Alison E Shone; Abhishek Srivastava; Paul A Stocks; Lee Taylor; Stephen A Ward; Ashley J Warman; Richard Amewu; Olivier Berger; Neil G Berry; Giancarlo A Biagini; Sitthivut Charoensutthivarakul; Nicholas E Fisher; Peter Gibbons; Alasdair Hill; W David Hong; Suet C Leung; Alison Mbekeani; Gemma L Nixon; Bénédicte Pacorel; Paul M O'Neill
Identification, design and biological evaluation of bisaryl quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).
Journal of medicinal chemistry 2012;55(5):1831-43.
2011: James Chadwick; Fatima Bousejra-El Garah; Francesc Marti; Richard K Amewu; Neil G Berry; Reto Brun; Hollie Burrell-Saward; Silvia Parapini; Matthias Rottmann; Raman Sharma; Paul A Stocks; Donatella Taramelli; Stephen A Ward; Sergio Wittlin; Paul M O'Neill
Antimalarial mannoxanes: hybrid antimalarial drugs with outstanding oral activity profiles and a potential dual mechanism of action.
ChemMedChem 2011;6(8):1357-61.
2010: Peter Gibbons; Edite Verissimo; Nuna C Araujo; Victoria Barton; Gemma L Nixon; Richard K Amewu; James Chadwick; Paul A Stocks; Giancarlo A Biagini; Abhishek Srivastava; Philip J Rosenthal; Jiri Gut; Rita C Guedes; Rui Moreira; Raman Sharma; Neil Berry; M Lurdes S Cristiano; Alison E Shone; Stephen A Ward; Paul M O'Neill
Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity.
Journal of medicinal chemistry 2010;53(22):8202-6.
2010: Richard Amewu; Peter Gibbons; Amira Mukhtar; Andrew V Stachulski; Stephen A Ward; Charlotte Hall; Karen Rimmer; Jill Davies; Livia Vivas; John Bacsa; Amy Mercer; Gemma Nixon; Paul A Stocks; Paul M O'Neill
Synthesis, in vitro and in vivo antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared via thiol-olefin co-oxygenation (TOCO) of allylic alcohols.
Organic & biomolecular chemistry 2010;8(9):2068-77.
2010: James Chadwick; Michael Jones; Amy Mercer; Paul A Stocks; Stephen A Ward; B Kevin Park; Paul M O'Neill
Design, synthesis and antimalarial/anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in Plasmodium falciparum and HL-60 cancer cell lines.
Bioorganic & medicinal chemistry 2010;18(7):2586-97.
2009: Paul M O'Neill; Alison E Shone; Deborah Stanford; Gemma Nixon; Eghbaleh Asadollahy; B Kevin Park; James L Maggs; Phil Roberts; Paul A Stocks; Giancarlo Biagini; Patrick G Bray; Jill Davies; Neil Berry; Charlotte Hall; Karen Rimmer; Peter A Winstanley; Stephen Hindley; Ramesh B Bambal; Charles B Davis; Martin Bates; Stephanie L Gresham; Richard A Brigandi; Federico M Gomez-de-Las-Heras; Domingo V Gargallo; Silvia Parapini; Livia Vivas; Hollie Lander; Donatella Taramelli; Stephen A Ward
Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable "back-up" compound for N-tert-butyl isoquine.
Journal of medicinal chemistry 2009;52(7):1828-44.
2009: Michael Jones; Amy Mercer; Paul A Stocks; Louise J I La Pensée; Richard Cosstick; B Kevin Park; Miriam E Kennedy; Ivo Piantanida; Stephen A Ward; Jill Davies; Patrick G Bray; Sarah L Rawe; Jonathan Baird; Tafadzwa Charidza; Omar Janneh; Paul M O'Neill
Antitumour and antimalarial activity of artemisinin-acridine hybrids.
Bioorganic & medicinal chemistry letters 2009;19(7):2033-7.
2009: Paul M O'Neill; B Kevin Park; Alison E Shone; James L Maggs; Phillip Roberts; Paul A Stocks; Giancarlo A Biagini; Patrick G Bray; Peter Gibbons; Neil Berry; Peter A Winstanley; Amira Mukhtar; Richard Bonar-Law; Stephen Hindley; Ramesh B Bambal; Charles B Davis; Martin Bates; Timothy K Hart; Stephanie L Gresham; Ron M Lawrence; Richard A Brigandi; Federico M Gomez-delas-Heras; Domingo V Gargallo; Stephen A Ward
Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century.
Journal of medicinal chemistry 2009;52(5):1408-15.
2008: Sunil Sabbani; Paul A Stocks; Gemma L Ellis; Jill Davies; Erik Hedenstrom; Stephen A Ward; Paul M O'Neill
Piperidine dispiro-1,2,4-trioxane analogues.
Bioorganic & medicinal chemistry letters 2008;18(21):5804-8.
2008: Giancarlo A Biagini; Nicholas Fisher; Neil Berry; Paul A Stocks; Brigitte Meunier; Dominic P Williams; Richard Bonar-Law; Patrick G Bray; Andrew Owen; Paul M O'Neill; Stephen A Ward
Acridinediones: selective and potent inhibitors of the malaria parasite mitochondrial bc1 complex.
Molecular pharmacology 2008;73(5):1347-55.
2008: Gemma L Ellis; Richard Amewu; Sunil Sabbani; Paul A Stocks; Alison Shone; Deborah Stanford; Peter Gibbons; Jill Davies; Livia Vivas; Sarah Charnaud; Emily Bongard; Charlotte Hall; Karen Rimmer; Sonia Lozanom; María Jesús; Domingo Gargallo; Stephen A Ward; Paul M O'Neill
Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles.
Journal of medicinal chemistry 2008;51(7):2170-7.
2007: Paul A Stocks; Patrick G Bray; Victoria E Barton; Mohammed Al-Helal; Michael Jones; Nuna C Araujo; Peter Gibbons; Stephen A Ward; Ruth H Hughes; Giancarlo A Biagini; Jill Davies; Richard Amewu; Amy Mercer; Gemma Ellis; Paul M O'Neill
Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs.
Angewandte Chemie (International ed. in English) 2007;46(33):6278-83.
2006: Patrick G Bray; Mathirut Mungthin; Ian M Hastings; Giancarlo A Biagini; Dauda K Saidu; Viswanathan Lakshmanan; David J Johnson; Ruth H Hughes; Paul A Stocks; Paul M O'Neill; Fidock David; david charles warhurst; Stephen A Ward
PfCRT and the trans-vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX.
Molecular microbiology 2006;62(1):238-51.
2006: Paul M O'Neill; Edite Verissimo; Stephen A Ward; Jill Davies; Edward E Korshin; Nuna C Araujo; Matthew D Pugh; M Lurdes S Cristiano; Paul A Stocks; Mario D Bachi
Diels-Alder/thiol-olefin co-oxygenation approach to antimalarials incorporating the 2,3-dioxabicyclo[3.3.1]nonane pharmacophore.
Bioorganic & medicinal chemistry letters 2006;16(11):2991-5.
2004: Paul M O'Neill; Amira Mukhtar; Stephen A Ward; Jamie F Bickley; Jill Davies; Mario D Bachi; Paul A Stocks
Application of thiol-olefin co-oxygenation methodology to a new synthesis of the 1,2,4-trioxane pharmacophore.
Organic letters 2004;6(18):3035-8.
2004: Paul M O'Neill; Paul A Stocks; Matthew D Pugh; Nuna C Araujo; Edward E Korshin; Jamie F Bickley; Stephen A Ward; Patrick G Bray; Erica Pasini; Jill Davies; Edite Verissimo; Mario D Bachi
Design and synthesis of endoperoxide antimalarial prodrug models.
Angewandte Chemie (International ed. in English) 2004;43(32):4193-7.
2003: Paul M O'Neill; Amira Mukhtar; Paul A Stocks; Laura E Randle; Stephen Hindley; Stephen A Ward; Richard C Storr; Jamie F Bickley; Ian A O'Neil; James L Maggs; Ruth H Hughes; Peter A Winstanley; Patrick G Bray; B Kevin Park
Isoquine and related amodiaquine analogues: a new generation of improved 4-aminoquinoline antimalarials.
Journal of medicinal chemistry 2003;46(23):4933-45.
2002: Paul A Stocks; Kaylene J Raynes; Patrick G Bray; B Kevin Park; Paul M O'Neill; Stephen A Ward
Novel short chain chloroquine analogues retain activity against chloroquine resistant K1 Plasmodium falciparum.
Journal of medicinal chemistry 2002;45(23):4975-83.
2001: A M Stead; Patrick G Bray; I G Edwards; H P DeKoning; B C Elford; Paul A Stocks; Stephen A Ward
Diamidine compounds: selective uptake and targeting in Plasmodium falciparum.
Molecular pharmacology 2001;59(5):1298-306.
1999: Kaylene J Raynes; Paul A Stocks; Paul M O'Neill; B Kevin Park; Stephen A Ward
New 4-aminoquinoline Mannich base antimalarials. 1. Effect of an alkyl substituent in the 5'-position of the 4'-hydroxyanilino side chain.
Journal of medicinal chemistry 1999;42(15):2747-51.