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Wilhelm Stoffel

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Molecular Sequence Data

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Chemicals & Drugs

Genes & Molecular Sequences

Amino Acid Sequences

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Cloning, Molecular

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Wilhelm Stoffel; Barbara Holz; Britta Jenke; Erika Binczek; Robert Heinz Günter; Christine Kiss; Iakowos Karakesisoglou; Mario Thevis; Artur-Aron Weber; Stephan Arnhold; Klaus Addicks
Delta6-desaturase (FADS2) deficiency unveils the role of omega3- and omega6-polyunsaturated fatty acids.
Wilhelm Stoffel; Britta Jenke; Barbara Holz; Erika Binczek; Robert Heinz Günter; Jutta Knifka; Jürgen Koebke; Anja Niehoff
Neutral sphingomyelinase (SMPD3) deficiency causes a novel form of chondrodysplasia and dwarfism that is rescued by Col2A1-driven smpd3 transgene expression.
Erika Binczek; Britta Jenke; Barbara Holz; Robert Heinz Günter; Mario Thevis; Wilhelm Stoffel
Obesity resistance of the stearoyl-CoA desaturase-deficient (scd1-/-) mouse results from disruption of the epidermal lipid barrier and adaptive thermoregulation.

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All Publications

2008: Wilhelm Stoffel; Barbara Holz; Britta Jenke; Erika Binczek; Robert Heinz Günter; Christine Kiss; Iakowos Karakesisoglou; Mario Thevis; Artur-Aron Weber; Stephan Arnhold; Klaus Addicks
Delta6-desaturase (FADS2) deficiency unveils the role of omega3- and omega6-polyunsaturated fatty acids.
The EMBO journal 2008;27(17):2281-92.
2007: Wilhelm Stoffel; Britta Jenke; Barbara Holz; Erika Binczek; Robert Heinz Günter; Jutta Knifka; Jürgen Koebke; Anja Niehoff
Neutral sphingomyelinase (SMPD3) deficiency causes a novel form of chondrodysplasia and dwarfism that is rescued by Col2A1-driven smpd3 transgene expression.
The American journal of pathology 2007;171(1):153-61.
2007: Erika Binczek; Britta Jenke; Barbara Holz; Robert Heinz Günter; Mario Thevis; Wilhelm Stoffel
Obesity resistance of the stearoyl-CoA desaturase-deficient (scd1-/-) mouse results from disruption of the epidermal lipid barrier and adaptive thermoregulation.
Biological chemistry 2007;388(4):405-18.
2005: Wilhelm Stoffel; Britta Jenke; Barbara Blöck; Markus Zumbansen; Jürgen Koebke
Neutral sphingomyelinase 2 (smpd3) in the control of postnatal growth and development.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(12):4554-9.
2004: Wilhelm Stoffel; Rafael Körner; Dagmar Wachtmann; Bernhard U Keller
Functional analysis of glutamate transporters in excitatory synaptic transmission of GLAST1 and GLAST1/EAAC1 deficient mice.
Brain research. Molecular brain research 2004;128(2):170-81.
2004: Walter F Haupt; Wilhelm Stoffel
Nerve conduction velocity measurements reveal the functional deficit in ceramide galactosyl transferase-deficient (cgt-/-) mice.
Journal of the neurological sciences 2004;217(1):83-8.
2002: Markus Zumbansen; Wilhelm Stoffel
Neutral sphingomyelinase 1 deficiency in the mouse causes no lipid storage disease.
Molecular and cellular biology 2002;22(11):3633-8.
2002: Uwe Janssen; Wilhelm Stoffel
Disruption of mitochondrial beta -oxidation of unsaturated fatty acids in the 3,2-trans-enoyl-CoA isomerase-deficient mouse.
The Journal of biological chemistry 2002;277(22):19579-84.
2002: Sven Dinslage; Wilhelm Stoffel; Michael Diestelhorst; Günter K Krieglstein
Tolerability and safety of two new preservative-free tear film substitutes.
Cornea 2002;21(4):352-5.
2002: Olaf Spörkel; Thomas Uschkureit; Heinrich Büssow; Wilhelm Stoffel
Oligodendrocytes expressing exclusively the DM20 isoform of the proteolipid protein gene: myelination and development.
Glia 2002;37(1):19-30.
2001: Thomas Uschkureit; O Spörkel; Heinrich Büssow; Wilhelm Stoffel
Rumpshaker-like proteolipid protein (PLP) ratio in a mouse model with unperturbed structural and functional integrity of the myelin sheath and axons in the central nervous system.
Glia 2001;35(1):63-71.
2000: Thomas Uschkureit; O Sporkel; J Stracke; H Bussow; Wilhelm Stoffel
Early onset of axonal degeneration in double (plp-/-mag-/-) and hypomyelinosis in triple (plp-/-mbp-/-mag-/-) mutant mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(14):5225-33.
2000: Kay Hofmann; S Tomiuk; G Wolff; Wilhelm Stoffel
Cloning and characterization of the mammalian brain-specific, Mg2+-dependent neutral sphingomyelinase.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(11):5895-900.
2000: M Nix; Wilhelm Stoffel
Perturbation of membrane microdomains reduces mitogenic signaling and increases susceptibility to apoptosis after T cell receptor stimulation.
Cell death and differentiation 2000;7(5):413-24.
2000: S Tomiuk; Markus Zumbansen; Wilhelm Stoffel
Characterization and subcellular localization of murine and human magnesium-dependent neutral sphingomyelinase.
The Journal of biological chemistry 2000;275(8):5710-7.
1999: Wilhelm Stoffel
Functional analysis of acid and neutral sphingomyelinases in vitro and in vivo.
Chemistry and physics of lipids 1999;102(1-2):107-21.
1998: S Wahle; Wilhelm Stoffel
Cotranslational integration of myelin proteolipid protein (PLP) into the membrane of endoplasmic reticulum: analysis of topology by glycosylation scanning and protease domain protection assay.
Glia 1998;24(2):226-35.
1998: A Bosio; Heinrich Büssow; J Adam; Wilhelm Stoffel
Galactosphingolipids and axono-glial interaction in myelin of the central nervous system.
Cell and tissue research 1998;292(2):199-210.
1998: S Tomiuk; Kay Hofmann; M Nix; Markus Zumbansen; Wilhelm Stoffel
Cloned mammalian neutral sphingomyelinase: functions in sphingolipid signaling?
Proceedings of the National Academy of Sciences of the United States of America 1998;95(7):3638-43.
1998: B Stoffel; P Bauer; M Nix; K Deres; Wilhelm Stoffel
Ceramide-independent CD28 and TCR signaling but reduced IL-2 secretion in T cells of acid sphingomyelinase-deficient mice.
European journal of immunology 1998;28(3):874-80.
1998: A Bosio; Erika Binczek; Walter F Haupt; Wilhelm Stoffel
Composition and biophysical properties of myelin lipid define the neurological defects in galactocerebroside- and sulfatide-deficient mice.
Journal of neurochemistry 1998;70(1):308-15.
1997: Wilhelm Stoffel; A Bosio
Myelin glycolipids and their functions.
Current opinion in neurobiology 1997;7(5):654-61.
1997: B Weiss; Wilhelm Stoffel
Human and murine serine-palmitoyl-CoA transferase--cloning, expression and characterization of the key enzyme in sphingolipid synthesis.
European journal of biochemistry / FEBS 1997;249(1):239-47.
1997: Wilhelm Stoffel; Detlev Boison; Heinrich Büssow
Functional analysis in vivo of the double mutant mouse deficient in both proteolipid protein (PLP) and myelin basic protein (MBP) in the central nervous system.
Cell and tissue research 1997;289(2):195-206.
1997: P Peghini; J Janzen; Wilhelm Stoffel
Glutamate transporter EAAC-1-deficient mice develop dicarboxylic aminoaciduria and behavioral abnormalities but no neurodegeneration.
The EMBO journal 1997;16(13):3822-32.
1997: Markus Zumbansen; Wilhelm Stoffel
Tumor necrosis factor alpha activates NF-kappaB in acid sphingomyelinase-deficient mouse embryonic fibroblasts.
The Journal of biological chemistry 1997;272(16):10904-9.
1997: U Janssen; E M Davis; M M Le Beau; Wilhelm Stoffel
Human mitochondrial enoyl-CoA hydratase gene (ECHS1): structural organization and assignment to chromosome 10q26.2-q26.3.
Genomics 1997;40(3):470-5.
1997: M Conradt; Wilhelm Stoffel
Inhibition of the high-affinity brain glutamate transporter GLAST-1 via direct phosphorylation.
Journal of neurochemistry 1997;68(3):1244-51.
1997: TA Kuemmel; R Schroeder; Wilhelm Stoffel
Light and electron microscopic analysis of the central and peripheral nervous systems of acid sphingomyelinase-deficient mice resulting from gene targeting.
Journal of neuropathology and experimental neurology 1997;56(2):171-9.
1997: TA Kuemmel; Hans Michael Kvasnicka; R Schroeder; Wilhelm Stoffel
Pathology of visceral organs and bone marrow in an acid sphingomyelinase deficient knock-out mouse line, mimicking human Niemann-Pick disease type A. A light and electron microscopic study.
Pathology, research and practice 1997;193(10):663-71.
1996: D Newrzella; Wilhelm Stoffel
Functional analysis of the glycosylation of murine acid sphingomyelinase.
The Journal of biological chemistry 1996;271(50):32089-95.
1996: S Wahle; Wilhelm Stoffel
Membrane topology of the high-affinity L-glutamate transporter (GLAST-1) of the central nervous system.
The Journal of cell biology 1996;135(6 Pt 2):1867-77.
1996: A Bosio; E Binczek; Wilhelm Stoffel
Functional breakdown of the lipid bilayer of the myelin membrane in central and peripheral nervous system by disrupted galactocerebroside synthesis.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(23):13280-5.
1996: A Bosio; E Binczek; Wilhelm Stoffel
Molecular cloning and characterization of the mouse CGT gene encoding UDP-galactose ceramide-galactosyltransferase (cerebroside synthetase).
Genomics 1996;35(1):223-6.
1996: Wilhelm Stoffel; J Sasse; M Düker; R Müller; Kay Hofmann; T Fink; P Lichter
Human high affinity, Na(+)-dependent L-glutamate/L-aspartate transporter GLAST-1 (EAAT-1): gene structure and localization to chromosome 5p11-p12.
FEBS letters 1996;386(2-3):189-93.
1996: A Bosio; E Binczek; M M Le Beau; A A Fernald; Wilhelm Stoffel
The human gene CGT encoding the UDP-galactose ceramide galactosyl transferase (cerebroside synthase): cloning, characterization, and assignment to human chromosome 4, band q26.
Genomics 1996;34(1):69-75.
1996: M M Hoffmann; Wilhelm Stoffel
Construction and functional characterization of recombinant fusion proteins of human lipoprotein lipase and apolipoprotein CII.
European journal of biochemistry / FEBS 1996;237(3):545-52.
1995: S Schulte; Wilhelm Stoffel
UDP galactose:ceramide galactosyltransferase and glutamate/aspartate transporter. Copurification, separation and characterization of the two glycoproteins.
European journal of biochemistry / FEBS 1995;233(3):947-53.
1995: M Conradt; Wilhelm Stoffel
Functional analysis of the high affinity, Na(+)-dependent glutamate transporter GLAST-1 by site-directed mutagenesis.
The Journal of biological chemistry 1995;270(42):25207-12.
1995: R Gutiérrez; Detlev Boison; Uwe Heinemann; Wilhelm Stoffel
Decompaction of CNS myelin leads to a reduction of the conduction velocity of action potentials in optic nerve.
Neuroscience letters 1995;195(2):93-6.
1995: Detlev Boison; Heinrich Büssow; D D'Urso; H W Müller; Wilhelm Stoffel
Adhesive properties of proteolipid protein are responsible for the compaction of CNS myelin sheaths.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(8):5502-13.
1995: B Otterbach; Wilhelm Stoffel
Acid sphingomyelinase-deficient mice mimic the neurovisceral form of human lysosomal storage disease (Niemann-Pick disease).
Cell 1995;81(7):1053-61.
1995: M Conradt; Thorsten Storck; Wilhelm Stoffel
Localization of N-glycosylation sites and functional role of the carbohydrate units of GLAST-1, a cloned rat brain L-glutamate/L-aspartate transporter.
European journal of biochemistry / FEBS 1995;229(3):682-7.
1995: G Müller-Newen; U Janssen; Wilhelm Stoffel
Enoyl-CoA hydratase and isomerase form a superfamily with a common active-site glutamate residue.
European journal of biochemistry / FEBS 1995;228(1):68-73.
1994: Detlev Boison; Wilhelm Stoffel
Disruption of the compacted myelin sheath of axons of the central nervous system in proteolipid protein-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(24):11709-13.
1994: Kay Hofmann; M Düker; T Fink; P Lichter; Wilhelm Stoffel
Human neutral amino acid transporter ASCT1: structure of the gene (SLC1A4) and localization to chromosome 2p13-p15.
Genomics 1994;24(1):20-6.
1994: Udo Klöckner; Thorsten Storck; M Conradt; Wilhelm Stoffel
Functional properties and substrate specificity of the cloned L-glutamate/L-aspartate transporter GLAST-1 from rat brain expressed in Xenopus oocytes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1994;14(10):5759-65.
1994: U Janssen; T Fink; P Lichter; Wilhelm Stoffel
Human mitochondrial 3,2-trans-enoyl-CoA isomerase (DCI): gene structure and localization to chromosome 16p13.3.
Genomics 1994;23(1):223-8.
1994: T Weimbs; Wilhelm Stoffel
Topology of CNS myelin proteolipid protein: evidence for the nonenzymatic glycosylation of extracytoplasmic domains in normal and diabetic animals.
Biochemistry 1994;33(34):10408-15.
1993: S Schulte; Wilhelm Stoffel
Ceramide UDPgalactosyltransferase from myelinating rat brain: purification, cloning, and expression.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(21):10265-9.
1993: G Müller-Newen; Wilhelm Stoffel
Site-directed mutagenesis of putative active-site amino acid residues of 3,2-trans-enoyl-CoA isomerase, conserved within the low-homology isomerase/hydratase enzyme family.
Biochemistry 1993;32(42):11405-12.
1993: Wilhelm Stoffel; M Düker; Kay Hofmann
Molecular cloning and gene organization of the mouse mitochondrial 3,2-trans-enoyl-CoA isomerase.
FEBS letters 1993;333(1-2):119-22.
1993: Udo Klöckner; Thorsten Storck; M Conradt; Wilhelm Stoffel
Electrogenic L-glutamate uptake in Xenopus laevis oocytes expressing a cloned rat brain L-glutamate/L-aspartate transporter (GLAST-1).
The Journal of biological chemistry 1993;268(20):14594-6.
1993: R Janz; Wilhelm Stoffel
Characterization of a brain-specific Sp1-like activity interacting with an unusual binding site within the myelin proteolipid protein promoter.
Biological chemistry Hoppe-Seyler 1993;374(7):507-17.
1993: B Otterbach; Wilhelm Stoffel; V Ramaekers
A novel mutation in the proteolipid protein gene leading to Pelizaeus-Merzbacher disease.
Biological chemistry Hoppe-Seyler 1993;374(1):75-83.
1992: T Weimbs; Wilhelm Stoffel
Proteolipid protein (PLP) of CNS myelin: positions of free, disulfide-bonded, and fatty acid thioester-linked cysteine residues and implications for the membrane topology of PLP.
Biochemistry 1992;31(49):12289-96.
1992: Thorsten Storck; S Schulte; Kay Hofmann; Wilhelm Stoffel
Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(22):10955-9.
1992: Wilhelm Stoffel; R Müller; E Binczek; Kay Hofmann
Mouse apolipoprotein AI. cDNA-derived primary structure, gene organisation and complete nucleotide sequence.
Biological chemistry Hoppe-Seyler 1992;373(4):187-93.
1991: F Schliess; Wilhelm Stoffel
Evolution of the myelin integral membrane proteins of the central nervous system.
Biological chemistry Hoppe-Seyler 1991;372(9):865-74.
1991: G Müller-Newen; Wilhelm Stoffel
Mitochondrial 3-2trans-Enoyl-CoA isomerase. Purification, cloning, expression, and mitochondrial import of the key enzyme of unsaturated fatty acid beta-oxidation.
Biological chemistry Hoppe-Seyler 1991;372(8):613-24.
1991: Wilhelm Stoffel; E Binczek
Transient expression of wild type and mutant human apolipoprotein AI in COS cells.
Biological chemistry Hoppe-Seyler 1991;372(7):481-8.
1991: J Kurth; Wilhelm Stoffel
Human placental sphingomyelinase. Purification to homogeneity, antigenic properties and partial amino-acid sequences of the enzyme.
Biological chemistry Hoppe-Seyler 1991;372(3):215-23.
1991: H Bruhn; Wilhelm Stoffel
An approach to the functional analysis of lecithin-cholesterol acyltransferase. Activation by recombinant normal and mutagenized apolipoprotein AI.
Biological chemistry Hoppe-Seyler 1991;372(3):225-34.
1990: T Weimbs; T Dick; Wilhelm Stoffel; E Boltshauser
A point mutation at the X-chromosomal proteolipid protein locus in Pelizaeus-Merzbacher disease leads to disruption of myelinogenesis.
Biological chemistry Hoppe-Seyler 1990;371(12):1175-83.
1990: J Kurth; Wilhelm Stoffel
A facile method for the isolation and preparation of proteins and peptides for sequence analysis in the picomolar range.
Biological chemistry Hoppe-Seyler 1990;371(8):675-85.
1990: S Euler-Bertram; Wilhelm Stoffel
Purification and characterization of bovine liver 3-cis-2-trans-enoyl-CoA isomerase.
Biological chemistry Hoppe-Seyler 1990;371(7):603-10.
1990: A Haase; Wilhelm Stoffel
The 3'-flanking region shared by the human apolipoprotein AI and CIII gene regulates gene expression in cooperation with 5'-flanking elements.
Biological chemistry Hoppe-Seyler 1990;371(4):375-82.
1989: Detlev Boison; Wilhelm Stoffel
Myelin-deficient rat: a point mutation in exon III (A----C, Thr75----Pro) of the myelin proteolipid protein causes dysmyelination and oligodendrocyte death.
The EMBO journal 1989;8(11):3295-302.
1989: R Streicher; Wilhelm Stoffel
The organization of the human myelin basic protein gene. Comparison with the mouse gene.
Biological chemistry Hoppe-Seyler 1989;370(5):503-10.
1988: Wilhelm Stoffel; E Binczek
Structural requirements of human preproapolipoprotein AI for translocation and processing studied by site-directed mutagenesis in vitro.
Biological chemistry Hoppe-Seyler 1988;369(9):1055-63.
1988: C Holtfreter; Wilhelm Stoffel
Expression of normal and mutagenized apolipoprotein CII in procaryotic cells. Structure-function relationship.
Biological chemistry Hoppe-Seyler 1988;369(9):1045-54.
1988: A Haase; Wilhelm Stoffel
Expression of the human serum apolipoprotein AI and AII genes in Xenopus laevis oocytes. Lipid-associated secretion of gene products.
Biological chemistry Hoppe-Seyler 1988;369(7):585-93.