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Jure Stojan

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Jure Stojan
The significance of low substrate concentration measurements for mechanistic interpretation in cholinesterases.
Sabina Berne; Stanislav Gobec; Branka Korošec; Nada Kraševec; Ljerka Lah; Metka Novak; Barbara Podobnik; Jure Stojan; Samo Turk; Neja Zupanec; Erika Šuligoj; Radovan Komel
Virtual screening yields inhibitors of novel antifungal drug target, benzoate 4-monooxygenase.
Cecilia Bartolucci; Nigel H Greig; Jure Stojan; Qian-sheng Yu; Doriano Lamba
Kinetics of Torpedo californica acetylcholinesterase inhibition by bisnorcymserine and crystal structure of the complex with its leaving group.

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All Publications

2013: Jure Stojan
The significance of low substrate concentration measurements for mechanistic interpretation in cholinesterases.
Chemico-biological interactions 2013;203(1):44-50.
2012: Sabina Berne; Stanislav Gobec; Branka Korošec; Nada Kraševec; Ljerka Lah; Metka Novak; Barbara Podobnik; Jure Stojan; Samo Turk; Neja Zupanec; Erika Šuligoj; Radovan Komel
Virtual screening yields inhibitors of novel antifungal drug target, benzoate 4-monooxygenase.
Journal of chemical information and modeling 2012;52(11):3053-63.
2012: Cecilia Bartolucci; Nigel H Greig; Jure Stojan; Qian-sheng Yu; Doriano Lamba
Kinetics of Torpedo californica acetylcholinesterase inhibition by bisnorcymserine and crystal structure of the complex with its leaving group.
The Biochemical journal 2012;444(2):269-77.
2012: Mojca Brunskole Svegelj; Jure Stojan; Tea Lanišnik Rižner
The role of Ala231 and Trp227 in the substrate specificities of fungal 17β-hydroxysteroid dehydrogenase and trihydroxynaphthalene reductase: Steroids versus smaller substrates.
The Journal of steroid biochemistry and molecular biology 2012;129(1-2):92-8.
2011: Dr Goran Sinko; Zrinka Kovarik; Elsa Reiner; Vera Simeon-Rudolf; Jure Stojan
Mechanism of stereoselective interaction between butyrylcholinesterase and ethopropazine enantiomers.
Biochimie 2011;93(10):1797-807.
2011: Ljerka Lah; Metka Novak; Barbara Podobnik; Jure Stojan; matjaz vogelsang; Neja Zupanec; Sabina Berne; Joerg Bohlmann; Branka Korošec; Nada Kraševec; Radovan Komel
The versatility of the fungal cytochrome P450 monooxygenase system is instrumental in xenobiotic detoxification.
Molecular microbiology 2011;81(5):1374-89.
2011: Mojca Brunskole Svegelj; Boris Brus; Tea Lanisnik Rizner; Jure Stojan; Samo Turk; Stanislav Gobec
Novel inhibitors of trihydroxynaphthalene reductase with antifungal activity identified by ligand-based and structure-based virtual screening.
Journal of chemical information and modeling 2011;51(7):1716-24.
2011: Staš Bevc; Milan Hodošček; Janez Konc; Matej Penca; Matej Praprotnik; Jure Stojan; Dušanka Janežič
ENZO: a web tool for derivation and evaluation of kinetic models of enzyme catalyzed reactions.
PloS one 2011;6(7):e22265.
2010: Jure Stojan
Non-productive binding of butyryl(thio)choline in the active site of vertebrate acetylcholinesterase.
Chemico-biological interactions 2010;187(1-3):128-34.
2010: Manuela F Frasco; Ida Erzen; Jure Stojan; Lúcia Guilhermino
Localization and properties of cholinesterases in the common prawn (Palaemon serratus): A kinetic-histochemical study.
The Biological bulletin 2010;218(1):1-5.
2009: Mojca Brunskole; Katja Kristan; Jure Stojan; Tea Lanisnik Rizner
Mutations that affect coenzyme binding and dimer formation of fungal 17beta-hydroxysteroid dehydrogenase.
Molecular and cellular endocrinology 2009;301(1-2):47-50.
2009: Jure Stojan; Mojca Brunskole; Tea Lanisnik Rizner
Simultaneous binding of coenzyme and two ligand molecules into the active site of fungal trihydroxynaphthalene reductase.
Chemico-biological interactions 2009;178(1-3):268-73.
2009: M Brunskole; K Zorko; V Kerbler; Stefan Martens; Jure Stojan; Stanislav Gobec; Tea Lanisnik Rizner
Trihydroxynaphthalene reductase of Curvularia lunata--a target for flavonoid action?
Chemico-biological interactions 2009;178(1-3):259-67.
2009: Katja Kristan; Mojca Brunskole; Jure Stojan; Tea Lanisnik Rizner
Two homologous fungal carbonyl reductases with different substrate specificities.
Chemico-biological interactions 2009;178(1-3):295-302.
2008: Jure Stojan
Kinetic evaluation of multiple initial rate data by simultaneous analysis with two equations.
Chemico-biological interactions 2008;175(1-3):242-8.
2008: Barbara Podobnik; Jure Stojan; Ljerka Lah; Nada Krasevec; Matej Seliskar; Tea Lanisnik Rizner; Damjana Rozman; Radovan Komel
CYP53A15 of Cochliobolus lunatus, a target for natural antifungal compounds.
Journal of medicinal chemistry 2008;51(12):3480-6.
2008: Mojca Brunskole; Bogdan Stefane; Karmen Zorko; Marko Anderluh; Jure Stojan; Tea Lanisnik Rizner; Stanislav Gobec
Towards the first inhibitors of trihydroxynaphthalene reductase from Curvularia lunata: synthesis of artificial substrate, homology modelling and initial screening.
Bioorganic & medicinal chemistry 2008;16(11):5881-9.
2008: Jure Stojan; Caroline Ladurantie; Omid Ranei Siadat; Laurent Paquereau; Didier Fournier
Evidence for subdomain flexibility in Drosophila melanogaster acetylcholinesterase.
Biochemistry 2008;47(20):5599-607.
2008: Florian Nachon; Jure Stojan; Didier Fournier
Insights into substrate and product traffic in the Drosophila melanogaster acetylcholinesterase active site gorge by enlarging a back channel.
The FEBS journal 2008;275(10):2659-64.
2007: Claudia Massa; Mads H Clausen; Jure Stojan; Doriano Lamba; Cristiana Campa
Study of the mode of action of a polygalacturonase from the phytopathogen Burkholderia cepacia.
The Biochemical journal 2007;407(2):207-17.
2007: Ota Fekonja; Majda Zorec-Karlovsek; Manale El Kharbili; Didier Fournier; Jure Stojan
Inhibition and protection of cholinesterases by methanol and ethanol.
Journal of enzyme inhibition and medicinal chemistry 2007;22(4):407-15.
2007: Manuela F Frasco; Jacques-Philippe Colletier; Martin Weik; Félix Carvalho; Lúcia Guilhermino; Jure Stojan; Didier Fournier
Mechanisms of cholinesterase inhibition by inorganic mercury.
The FEBS journal 2007;274(7):1849-61.
2007: Katja Kristan; Jure Stojan; Jerzy Adamski; Tea Lanisnik Rizner
Rational design of novel mutants of fungal 17beta-hydroxysteroid dehydrogenase.
Journal of biotechnology 2007;129(1):123-30.
2007: Katja Kristan; Jerzy Adamski; Tea Lanisnik Rizner; Jure Stojan
His164 regulates accessibility to the active site in fungal 17beta-hydroxysteroid dehydrogenase.
Biochimie 2007;89(1):63-71.
2006: Jacques-Philippe Colletier; Didier Fournier; Harry M Greenblatt; Jure Stojan; Joel Sussman; Giuseppe Zaccai; Israel Silman; Martin Weik
Structural insights into substrate traffic and inhibition in acetylcholinesterase.
The EMBO journal 2006;25(12):2746-56.
2005: Jure Stojan
Rational polynomial equation helps to select among homeomorphic kinetic models for cholinesterase reaction mechanism.
Chemico-biological interactions 2005;157-158():173-9.
2005: Alberto Cassetta; Tomaz Büdefeld; Tea Lanisnik Rizner; Katja Kristan; Jure Stojan; Doriano Lamba
Crystallization, X-ray diffraction analysis and phasing of 17beta-hydroxysteroid dehydrogenase from the fungus Cochliobolus lunatus.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 12):1032-4.
2005: Anders Florén; Ulla Sollenberg; Linda Lundström; Matjaz Zorko; Jure Stojan; Metka V Budihna; Mark Wheatley; Negin P Martin; Kalle Kilk; Andrey Mazarati; Tamas Bartfai; Maria Lindgren; Ulo Langel
Multiple interaction sites of galnon trigger its biological effects.
Neuropeptides 2005;39(6):547-58.
2005: Katja Kristan; Jure Stojan; Gabriele Möller; Jerzy Adamski; Tea Lanisnik Rizner
Coenzyme specificity in fungal 17beta-hydroxysteroid dehydrogenase.
Molecular and cellular endocrinology 2005;241(1-2):80-7.
2005: Katja Kristan; Katja Krajnc; Janez Konc; Stanislav Gobec; Jure Stojan; Tea Lanisnik Rizner
Phytoestrogens as inhibitors of fungal 17beta-hydroxysteroid dehydrogenase.
Steroids 2005;70(10):694-703.
2005: Katja Kristan; Katja Krajnc; Janez Konc; Stanislav Gobec; Jure Stojan; Tea Lanisnik Rizner
Phytoestrogens as inhibitors of fungal 17beta-hydroxysteroid dehydrogenase.
Steroids 2005;70(9):626-35.
2005: Katja Kristan; Dominga Deluca; Jerzy Adamski; Jure Stojan; Tea Lanisnik Rizner
Dimerization and enzymatic activity of fungal 17beta-hydroxysteroid dehydrogenase from the short-chain dehydrogenase/reductase superfamily.
BMC biochemistry 2005;6():28.
2004: Jure Stojan; Marko Golicnik; Didier Fournier
Rational polynomial equation as an unbiased approach for the kinetic studies of Drosophila melanogaster acetylcholinesterase reaction mechanism.
Biochimica et biophysica acta 2004;1703(1):53-61.
2004: Marko Goliĉnik; Jure Stojan
Slow-binding inhibition: A theoretical and practical course for students.
Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology 2004;32(4):228-35.
2004: Tanja Vilfan; Bronislava Cresnar; Didier Fournier; Jure Stojan; Katja Breskvar
Characterisation and expression of a gene encoding a mutarotase from the fungus Rhizopus nigricans.
FEMS microbiology letters 2004;235(1):101-8.
2004: Jure Stojan; Laure Brochier; Carole Alies; Jacques-Philippe Colletier; Didier Fournier
Inhibition of Drosophila melanogaster acetylcholinesterase by high concentrations of substrate.
European journal of biochemistry / FEBS 2004;271(7):1364-71.
2004: Petra Marinko; Ales Krbavcic; Gregor Mlinsek; Tom Solmajer; Alenka Trampus Bakija; Mojca Stegnar; Jure Stojan; Danijel Kikelj
Novel non-covalent thrombin inhibitors incorporating P(1) 4,5,6,7-tetrahydrobenzothiazole arginine side chain mimetics.
European journal of medicinal chemistry 2004;39(3):257-65.
2004: Ming An Shi; Andrée Lougarre; Carole Alies; Isabelle Frémaux; Zhen Hua Tang; Jure Stojan; Didier Fournier
Acetylcholinesterase alterations reveal the fitness cost of mutations conferring insecticide resistance.
BMC evolutionary biology 2004;4():5.
2003: Marko Golicnik; Jure Stojan
Generalized theoretical and practical treatment of the kinetics of an enzyme-catalyzed reaction in the presence of an enzyme equimolar irreversible inhibitor.
Journal of chemical information and computer sciences 2003;43(5):1486-93.
2003: Katja Kristan; Tea Lanisnik Rizner; Jure Stojan; Josef K Gerber; Elisabeth Kremmer; Jerzy Adamski
Significance of individual amino acid residues for coenzyme and substrate specificity of 17beta-hydroxysteroid dehydrogenase from the fungus Cochliobolus lunatus.
Chemico-biological interactions 2003;143-144():493-501.
2002: Marko Golicnik; Jure Stojan
Transient kinetic approach to the study of acetylcholinesterase reversible inhibition by eseroline.
Journal of enzyme inhibition and medicinal chemistry 2002;17(5):279-85.
2002: Marko Golicnik; Jure Stojan
Multi-step analysis as a tool for kinetic parameter estimation and mechanism discrimination in the reaction between tight-binding fasciculin 2 and electric eel acetylcholinesterase.
Biochimica et biophysica acta 2002;1597(1):164-72.
2002: Marko Golicnik; Didier Fournier; Jure Stojan
Acceleration of Drosophila melanogaster acetylcholinesterase methanesulfonylation: peripheral ligand D-tubocurarine enhances the affinity for small methanesulfonylfluoride.
Chemico-biological interactions 2002;139(2):145-57.
2002: Jure Stojan; Marko Golicnik; Marie-Thérèse Froment; Francois Estour; Patrick Masson
Concentration-dependent reversible activation-inhibition of human butyrylcholinesterase by tetraethylammonium ion.
European journal of biochemistry / FEBS 2002;269(4):1154-61.
2002: Marko Golicnik; Dr Goran Sinko; Vera Simeon-Rudolf; Zoran Grubic; Jure Stojan
Kinetic model of ethopropazine interaction with horse serum butyrylcholinesterase and its docking into the active site.
Archives of biochemistry and biophysics 2002;398(1):23-31.
2001: Mirjana Liovic; Jure Stojan; Paul E Bowden; Daniel Gibbs; Anders Vahlquist; E Birgitte Lane; Radovan Komel
A novel keratin 5 mutation (K5V186L) in a family with EBS-K: a conservative substitution can lead to development of different disease phenotypes.
The Journal of investigative dermatology 2001;116(6):964-9.
2001: Marko Golicnik; Didier Fournier; Jure Stojan
Interaction of Drosophila acetylcholinesterases with D-tubocurarine: an explanation of the activation by an inhibitor.
Biochemistry 2001;40(5):1214-9.
2001: Tea Lanisnik Rizner; Jure Stojan; Jerzy Adamski
17beta-hydroxysteroid dehydrogenase from the fungus Cochliobolus lunatus: structural and functional aspects.
Chemico-biological interactions 2001;130-132(1-3):793-803.
2001: Tea Lanisnik Rizner; Jure Stojan; Jerzy Adamski
Searching for the physiological function of 17beta-hydroxysteroid dehydrogenase from the fungus Cochliobolus lunatus: studies of substrate specificity and expression analysis.
Molecular and cellular endocrinology 2001;171(1-2):193-8.
2001: Jure Stojan
Slow detection reaction can mimic initial inhibition of an enzymic reaction.
Journal of enzyme inhibition 2001;16(2):89-94.
2000: Tea Lanisnik Rizner; Jerzy Adamski; Jure Stojan
17Beta-hydroxysteroid dehydrogenase from Cochliobolus lunatus: model structure and substrate specificity.
Archives of biochemistry and biophysics 2000;384(2):255-62.
2000: V Marcel; Sandino Estrada-Mondaca; F Magné; Jure Stojan; Alain Klaébé; Didier Fournier
Exploration of the Drosophila acetylcholinesterase substrate activation site using a reversible inhibitor (Triton X-100) and mutated enzymes.
The Journal of biological chemistry 2000;275(16):11603-9.
1999: Jure Stojan; V Marcel; Didier Fournier
Inhibition of Drosophila acetylcholinesterase by 7-(methylethoxyphosphinyloxy)1-methyl-quinolinium iodide.
Chemico-biological interactions 1999;119-120():147-57.
1999: Jure Stojan; V Marcel; Didier Fournier
Effect of tetramethylammonium, choline and edrophonium on insect acetylcholinesterase: test of a kinetic model.
Chemico-biological interactions 1999;119-120():137-46.
1999: Marjeta Sentjurc; Slavko Pecar; Jure Stojan; Pascale Marchot; Z Radić; Zoran Grubic
Electron paramagnetic resonance reveals altered topography of the active center gorge of acetylcholinesterase after binding of fasciculin to the peripheral site.
Biochimica et biophysica acta 1999;1430(2):349-58.
1999: Jure Stojan
Homology built model of acetylcholinesterase from Drosophila melanogaster.
Journal of enzyme inhibition 1999;14(3):193-201.
1998: Jure Stojan; V Marcel; Sandino Estrada-Mondaca; A Klaebe; P Masson; Didier Fournier
A putative kinetic model for substrate metabolisation by Drosophila acetylcholinesterase.
FEBS letters 1998;440(1-2):85-8.
1998: Jure Stojan
Equations for progress curves of some kinetic models of enzyme-single substrate-single slow binding modifier system.
Journal of enzyme inhibition 1998;13(3):161-76.
1997: Jure Stojan; Matjaz Zorko
Kinetic characterization of all steps of the interaction between acetylcholinesterase and eserine.
Biochimica et biophysica acta 1997;1337(1):75-84.
1997: Jure Stojan; M R Pavlic
Mechanism of eserine action on the hydrolysis of butyrylthiocholine by butyrylcholinesterase.
Journal of enzyme inhibition 1997;11(3):199-208.
1994: Jure Stojan; M R Pavlic
The influence of an organosulfonate on the reaction between Ellman's reagent and thiocholine.
Journal of analytical toxicology 1994;18(3):165-7.
1992: Jure Stojan; M R Pavlic
Velocity of Ellman's reaction and its implication for kinetic studies in the millisecond time range.
Neurochemical research 1992;17(12):1207-10.
1991: Jure Stojan; M R Pavlic
On the inhibition of cholinesterase by D-tubocurarine.
Biochimica et biophysica acta 1991;1079(1):96-102.