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James Stone

Research Profile

Chemicals & Drugs

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Rats
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Publications

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Dominic P Golec; James C Stone; Nancy A Dower; Troy A Baldwin
RasGRP1, but not RasGRP3, is required for efficient thymic β-selection and ERK activation downstream of CXCR4.
Ana Lopez-Campistrous; Adam J Schrier; Xiaohua Song; Nancy A Dower; Paul A Wender; James C Stone
Bryostatin analogue-induced apoptosis in mantle cell lymphoma cell lines.
James C Stone
Regulation and Function of the RasGRP Family of Ras Activators in Blood Cells.

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All Publications

2013: Dominic P Golec; James C Stone; Nancy A Dower; Troy A Baldwin
RasGRP1, but not RasGRP3, is required for efficient thymic β-selection and ERK activation downstream of CXCR4.
PloS one 2013;8(1):e53300.
2012: Ana Lopez-Campistrous; Adam J Schrier; Xiaohua Song; Nancy A Dower; Paul A Wender; James C Stone
Bryostatin analogue-induced apoptosis in mantle cell lymphoma cell lines.
Experimental hematology 2012;40(8):646-56.e2.
2011: James C Stone
Regulation and Function of the RasGRP Family of Ras Activators in Blood Cells.
Genes & cancer 2011;2(3):320-34.
2010: John J Priatel; Xiaoxi Chen; Yu-Hsuan Huang; Michael T Chow; Lauren A Zenewicz; Jason J Coughlin; Hao Shen; James C Stone; Rusung Tan; Hung-Sia Teh
RasGRP1 regulates antigen-induced developmental programming by naive CD8 T cells.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(2):666-76.
2009: Ho Y Poon; James C Stone
Functional links between diacylglycerol and phosphatidylinositol signaling systems in human leukocyte-derived cell lines.
Biochemical and biophysical research communications 2009;390(4):1395-401.
2006: James C Stone
Regulation of Ras in lymphocytes: get a GRP.
Biochemical Society transactions 2006;34(Pt 5):858-61.
2006: Yuanyuan Zha; Reinhard Marks; Allen W Ho; Amy C Peterson; Sujit Janardhan; Ian Brown; Kesavannair Praveen; Stacey L Stang; James C Stone; Thomas F Gajewski
T cell anergy is reversed by active Ras and is regulated by diacylglycerol kinase-alpha.
Nature immunology 2006;7(11):1166-73.
2006: Jason J Coughlin; Stacey L Stang; Nancy A Dower; James C Stone
The role of RasGRPs in regulation of lymphocyte proliferation.
Immunology letters 2006;105(1):77-82.
2005: Jason J Coughlin; Stacey L Stang; Nancy A Dower; James C Stone
RasGRP1 and RasGRP3 regulate B cell proliferation by facilitating B cell receptor-Ras signaling.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(11):7179-84.
2005: Yongmei Pu; Nicholas A Perry; Dazhi Yang; Nancy E Lewin; Noemi Kedei; Derek C Braun; Sung Hee Choi; Peter M Blumberg; Susan H Garfield; James C Stone; Dehui Duan; Victor E Marquez
A novel diacylglycerol-lactone shows marked selectivity in vitro among C1 domains of protein kinase C (PKC) isoforms alpha and delta as well as selectivity for RasGRP compared with PKCalpha.
The Journal of biological chemistry 2005;280(29):27329-38.
2005: Yong Zheng; Huaizhi Liu; Jason J Coughlin; Jing Zheng; Liang Li; James C Stone
Phosphorylation of RasGRP3 on threonine 133 provides a mechanistic link between PKC and Ras signaling systems in B cells.
Blood 2005;105(9):3648-54.
2004: James C Stone; Stacey L Stang; Yong Zheng; Nancy A Dower; Stacey E Brenner; Jeremy L Baryza; Paul A Wender
Synthetic bryostatin analogues activate the RasGRP1 signaling pathway.
Journal of medicinal chemistry 2004;47(26):6638-44.
2004: Chaya Brodie; Rivka Steinhart; Gila Kazimirsky; Hadara Rubinfeld; Tehila Hyman; Jolene N Ayres; Gang Min Hur; Attila Toth; Dazhi Yang; Susan H Garfield; James C Stone; Peter M Blumberg
PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters.
Molecular pharmacology 2004;66(1):76-84.
2003: Reshmi A Rambaratsingh; James C Stone; Peter M Blumberg; Patricia S Lorenzo
RasGRP1 represents a novel non-protein kinase C phorbol ester signaling pathway in mouse epidermal keratinocytes.
The Journal of biological chemistry 2003;278(52):52792-801.
2003: Christine Teixeira; Stacey L Stang; Yong Zheng; Naomi S Beswick; James C Stone
Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3.
Blood 2003;102(4):1414-20.
2003: Katrin Layer; Guosheng Lin; Alessio Nencioni; Wei Hu; Adam Schmucker; Andrey N Antov; Xiaoyu Li; Satoshi Takamatsu; Timothy Chevassut; Nancy A Dower; Stacey L Stang; David Beier; Janet Buhlmann; Roderick T Bronson; Keith B Elkon; James C Stone; Luk Van Parijs; Bing Lim
Autoimmunity as the consequence of a spontaneous mutation in Rasgrp1.
Immunity 2003;19(2):243-55.
2003: Alexander S Clanachan; Jagdip S Jaswal; Manoj Gandhi; Drell A Bottorff; Jason J Coughlin; Barry A Finegan; James C Stone
Effects of inhibition of myocardial extracellular-responsive kinase and P38 mitogen-activated protein kinase on mechanical function of rat hearts after prolonged hypothermic ischemia.
Transplantation 2003;75(2):173-80.
2002: John J Priatel; Soo-Jeet Teh; Nancy A Dower; James C Stone; Hung-Sia Teh
RasGRP1 transduces low-grade TCR signals which are critical for T cell development, homeostasis, and differentiation.
Immunity 2002;17(5):617-27.
2002: Edmond Y W Chan; Stacey L Stang; Drell A Bottorff; James C Stone
Mutations in conserved regions 1, 2, and 3 of Raf-1 that activate transforming activity.
Molecular carcinogenesis 2002;33(4):189-97.
2002: Suo-Bao Rong; Istvan J Enyedy; Lixin Qiao; Lianyun Zhao; Dawei Ma; Larry L Pearce; Patricia S Lorenzo; James C Stone; Peter M Blumberg; Shaomeng Wang; Alan P Kozikowski
Structural basis of RasGRP binding to high-affinity PKC ligands.
Journal of medicinal chemistry 2002;45(4):853-60.
2002: Philippe Pierret; N Mechawar; Annie Vallée; J Patel; John V Priestley; Robert J Dunn; Nancy A Dower; James C Stone; Peter M Richardson
Presence of Ras guanyl nucleotide-releasing protein in striosomes of the mature and developing rat.
Neuroscience 2002;111(1):83-94.
2001: Lei Shao; Nancy E Lewin; Patricia S Lorenzo; Zengjian Hu; Istvan J Enyedy; Susan H Garfield; James C Stone; F J Marner; Peter M Blumberg; Shaomeng Wang
Iridals are a novel class of ligands for phorbol ester receptors with modest selectivity for the RasGRP receptor subfamily.
Journal of medicinal chemistry 2001;44(23):3872-80.
2001: Patricia S Lorenzo; J W Kung; Drell A Bottorff; Susan H Garfield; James C Stone; Peter M Blumberg
Phorbol esters modulate the Ras exchange factor RasGRP3.
Cancer research 2001;61(3):943-9.
2001: Philippe Pierret; Annie Vallée; N Mechawar; Nancy A Dower; James C Stone; Peter M Richardson; Robert J Dunn
Cellular and subcellular localization of Ras guanyl nucleotide-releasing protein in the rat hippocampus.
Neuroscience 2001;108(3):381-90.
2000: Lawrence G Puente; James C Stone; Hanne L Ostergaard
Evidence for protein kinase C-dependent and -independent activation of mitogen-activated protein kinase in T cells: potential role of additional diacylglycerol binding proteins.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):6865-71.
2000: Nancy A Dower; Stacey L Stang; Drell A Bottorff; JO Ebinu; Peter Dickie; Hanne L Ostergaard; James C Stone
RasGRP is essential for mouse thymocyte differentiation and TCR signaling.
Nature immunology 2000;1(4):317-21.
2000: Philippe Pierret; Robert J Dunn; B Djordjevic; James C Stone; Peter M Richardson
Distribution of ras guanyl releasing protein (RasGRP) mRNA in the adult rat central nervous system.
Journal of neurocytology 2000;29(7):485-97.
2000: JO Ebinu; Stacey L Stang; Christine Teixeira; Drell A Bottorff; Jonathan W Hooton; Peter M Blumberg; M Barry; R C Bleakley; Hanne L Ostergaard; James C Stone
RasGRP links T-cell receptor signaling to Ras.
Blood 2000;95(10):3199-203.
2000: Patricia S Lorenzo; M Beheshti; George R Pettit; James C Stone; Peter M Blumberg
The guanine nucleotide exchange factor RasGRP is a high -affinity target for diacylglycerol and phorbol esters.
Molecular pharmacology 2000;57(5):840-6.
1999: Edmond Y W Chan; Stacey L Stang; Drell A Bottorff; James C Stone
Hypothermic stress leads to activation of Ras-Erk signaling.
The Journal of clinical investigation 1999;103(9):1337-44.
1999: AN Hanna; Edmond Y W Chan; Jianhua Xu; James C Stone; David N Brindley
A novel pathway for tumor necrosis factor-alpha and ceramide signaling involving sequential activation of tyrosine kinase, p21(ras), and phosphatidylinositol 3-kinase.
The Journal of biological chemistry 1999;274(18):12722-9.
1999: Drell A Bottorff; JO Ebinu; James C Stone
RasGRP, a Ras activator: mouse and human cDNA sequences and chromosomal positions.
Mammalian genome : official journal of the International Mammalian Genome Society 1999;10(4):358-61.
1998: JO Ebinu; Drell A Bottorff; Edmond Y W Chan; Stacey L Stang; Robert J Dunn; James C Stone
RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs.
Science (New York, N.Y.) 1998;280(5366):1082-6.
1997: Stacey L Stang; Drell A Bottorff; James C Stone
Interaction of activated Ras with Raf-1 alone may be sufficient for transformation of rat2 cells.
Molecular and cellular biology 1997;17(6):3047-55.
1997: A Martin; P A Duffy; C Liossis; A Gomez-Muñoz; L O'Brien; James C Stone; David N Brindley
Increased concentrations of phosphatidate, diacylglycerol and ceramide in ras- and tyrosine kinase (fps)-transformed fibroblasts.
Oncogene 1997;14(13):1571-80.
1996: S Agellon; James C Stone
Stimulation of ras GTPase activity by an anti-ras monoclonal antibody.
Molecular carcinogenesis 1996;16(3):132-8.
1996: Stacey L Stang; Drell A Bottorff; James C Stone
ras effector loop mutations that dissociate p120GAP and neurofibromin interactions.
Molecular carcinogenesis 1996;15(1):64-9.
1995: Drell A Bottorff; Stacey L Stang; S Agellon; James C Stone
RAS signalling is abnormal in a c-raf1 MEK1 double mutant.
Molecular and cellular biology 1995;15(9):5113-22.
1994: T E Hebert; R Monette; James C Stone; Pierre Drapeau; Robert J Dunn
Insertion mutations of the RIIA Na+ channel reveal novel features of voltage gating and protein kinase A modulation.
Pflügers Archiv : European journal of physiology 1994;427(5-6):500-9.
1993: James C Stone; M Colleton; Drell A Bottorff
Effector domain mutations dissociate p21ras effector function and GTPase-activating protein interaction.
Molecular and cellular biology 1993;13(12):7311-20.
1993: A Martin; A Gomez-Muñoz; DW Waggoner; James C Stone; David N Brindley
Decreased activities of phosphatidate phosphohydrolase and phospholipase D in ras and tyrosine kinase (fps) transformed fibroblasts.
The Journal of biological chemistry 1993;268(32):23924-32.
1992: N A Dower; Michael F Seldin; S Pugh; James C Stone
Organization and chromosomal locations of Rap1a/Krev sequences in the mouse.
Mammalian genome : official journal of the International Mammalian Genome Society 1992;3(3):162-7.
1992: Drell A Bottorff; James C Stone
The murine leukemia inhibition factor gene (Lif) is located on proximal chromosome 11, not chromosome 13.
Mammalian genome : official journal of the International Mammalian Genome Society 1992;3(12):681-4.
1991: James C Stone; R A Blanchard
Genetic definition of ras effector elements.
Molecular and cellular biology 1991;11(12):6158-65.
1991: Jeffrey E DeClue; James C Stone; R A Blanchard; Alex G Papageorge; P Martin; K Zhang; Douglas Lowy
A ras effector domain mutant which is temperature sensitive for cellular transformation: interactions with GTPase-activating protein and NF-1.
Molecular and cellular biology 1991;11(6):3132-8.
1986: James C Stone; N A Dower; L Siminovitch
Stability of retrovirally transduced markers in a rat cell line.
Somatic cell and molecular genetics 1986;12(6):575-83.
1983: James C Stone; N A Dower; J Hauseman; Y M Cseko; R Sederoff
The characterization of a mutant affecting DNA metabolism in the development of D. melanogaster.
Canadian journal of genetics and cytology. Journal canadien de génétique et de cytologie 1983;25(2):129-38.