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Michael Stone

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Manjori Ganguly; Kate Clancy; Patrick S Donahue; Michael P Stone; Marta W Szulik; Barry Gold
Thermodynamic signature of DNA damage: characterization of DNA with a 5-hydroxy-2'-deoxycytidine·2'-deoxyguanosine base pair.
Surajit Banerjee; Plamen P Christov; Martin Egli; Albena Kozekova; Carmelo J Rizzo; Michael P Stone
Replication bypass of the trans-4-Hydroxynonenal-derived (6S,8R,11S)-1,N(2)-deoxyguanosine DNA adduct by the sulfolobus solfataricus DNA polymerase IV.
Hai Huang; Ashis K Basu; Rajat S Das; Michael P Stone
Structures of (5'S)-8,5'-Cyclo-2'-deoxyguanosine Mismatched with dA or dT.

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All Publications

2012: Manjori Ganguly; Kate Clancy; Patrick S Donahue; Michael P Stone; Marta W Szulik; Barry Gold
Thermodynamic signature of DNA damage: characterization of DNA with a 5-hydroxy-2'-deoxycytidine·2'-deoxyguanosine base pair.
Biochemistry 2012;51(9):2018-27.
2012: Surajit Banerjee; Plamen P Christov; Martin Egli; Albena Kozekova; Carmelo J Rizzo; Michael P Stone
Replication bypass of the trans-4-Hydroxynonenal-derived (6S,8R,11S)-1,N(2)-deoxyguanosine DNA adduct by the sulfolobus solfataricus DNA polymerase IV.
Chemical research in toxicology 2012;25(2):422-35.
2012: Hai Huang; Ashis K Basu; Rajat S Das; Michael P Stone
Structures of (5'S)-8,5'-Cyclo-2'-deoxyguanosine Mismatched with dA or dT.
Chemical research in toxicology 2012;25(2):478-90.
2011: Ewa A Kowal; Luis A Marky; Pradeep S Pallan; Martin Egli; Manjori Ganguly; Barry Gold; Michael P Stone
Altering the electrostatic potential in the major groove: thermodynamic and structural characterization of 7-deaza-2'-deoxyadenosine:dT base pairing in DNA.
The journal of physical chemistry. B 2011;115(47):13925-34.
2011: Hai Huang; Albena Kozekova; Carmelo J Rizzo; Hao Wang; Michael P Stone
Formation of a N2-dG:N2-dG carbinolamine DNA cross-link by the trans-4-hydroxynonenal-derived (6S,8R,11S) 1,N2-dG adduct.
Journal of the American Chemical Society 2011;133(40):16101-10.
2011: Michael P Stone; Kyle L Brown; Hai Huang; Ganesh Shanmugam
Chemistry and structural biology of DNA damage and biological consequences.
Chemistry & biodiversity 2011;8(9):1571-615.
2011: Surajit Banerjee; Kyle L Brown; Martin Egli; Michael P Stone
Bypass of aflatoxin B1 adducts by the Sulfolobus solfataricus DNA polymerase IV.
Journal of the American Chemical Society 2011;133(32):12556-68.
2011: Sreelekha K Singh; Michael P Stone; Marta W Szulik; Manjori Ganguly; Irine Khutsishvili; Luis A Marky; Barry Gold
Characterization of DNA with an 8-oxoguanine modification.
Nucleic acids research 2011;39(15):6789-801.
2011: Ganesh Shanmugam; F Peter Guengerich; Ivan D Kozekov; Carmelo J Rizzo; Michael P Stone
1,N2-Etheno-2'-deoxyguanosine adopts the syn conformation about the glycosyl bond when mismatched with deoxyadenosine.
Chemical research in toxicology 2011;24(7):1071-9.
2011: Hai Huang; Albena Kozekova; R Stephen Lloyd; Amanda K McCullough; Carmelo J Rizzo; Markus Voehler; Hao Wang; Michael P Stone
γ-Hydroxy-1,N2-propano-2'-deoxyguanosine DNA adduct conjugates the N-terminal amine of the KWKK peptide via a carbinolamine linkage.
Chemical research in toxicology 2011;24(7):1123-33.
2010: Plamen P Christov; Katya V Petrova; Ganesh Shanmugam; Ivan D Kozekov; Albena Kozekova; F Peter Guengerich; Michael P Stone; Carmelo J Rizzo
Comparison of the in vitro replication of the 7-(2-oxoheptyl)-1,N2-etheno-2'-deoxyguanosine and 1,N2-etheno-2'-deoxyguanosine lesions by Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4).
Chemical research in toxicology 2010;23(8):1330-41.
2010: Hai Huang; Ivan D Kozekov; Albena Kozekova; Carmelo J Rizzo; Amanda K McCullough; R Stephen Lloyd; Michael P Stone
Minor groove orientation of the KWKK peptide tethered via the N-terminal amine to the acrolein-derived 1,N2-gamma-hydroxypropanodeoxyguanosine lesion with a trimethylene linkage.
Biochemistry 2010;49(29):6155-64.
2010: Hai Huang; Ivan D Kozekov; Albena Kozekova; Hao Wang; R Stephen Lloyd; Carmelo J Rizzo; Michael P Stone
DNA cross-link induced by trans-4-hydroxynonenal.
Environmental and molecular mutagenesis 2010;51(6):625-34.
2010: Plamen P Christov; Goutam Chowdhury; Craig A Garmendia; Feng Wang; James S Stover; C Eric Elmquist; Albena Kozekova; Karen C Angel; Robert J Turesky; Michael P Stone; F Peter Guengerich; Carmelo J Rizzo
The C8-2'-deoxyguanosine adduct of 2-amino-3-methylimidazo[1,2-d]naphthalene, a carbocyclic analogue of the potent mutagen 2-amino-3-methylimidazo[4,5-f]quinoline, is a block to replication in vitro.
Chemical research in toxicology 2010;23(6):1076-88.
2010: Plamen P Christov; Surajit Banerjee; Michael P Stone; Carmelo J Rizzo
Selective Incision of the alpha-N-Methyl-Formamidopyrimidine Anomer by Escherichia coli Endonuclease IV.
Journal of nucleic acids 2010;2010():.
2010: Kyle L Brown; Marina Roginskaya; Yue Zou; Alvin Altamirano; Ashis K Basu; Michael P Stone
Binding of the human nucleotide excision repair proteins XPA and XPC/HR23B to the 5R-thymine glycol lesion and structure of the cis-(5R,6S) thymine glycol epimer in the 5'-GTgG-3' sequence: destabilization of two base pairs at the lesion site.
Nucleic acids research 2010;38(2):428-40.
2009: Kyle L Brown; Markus Voehler; Shane M Magee; Constance M Harris; Thomas M Harris; Michael P Stone
Structural perturbations induced by the alpha-anomer of the aflatoxin B(1) formamidopyrimidine adduct in duplex and single-strand DNA.
Journal of the American Chemical Society 2009;131(44):16096-107.
2009: Hai Huang; Patricia A Dooley; Constance M Harris; Thomas M Harris; Michael P Stone
Differential base stacking interactions induced by trimethylene interstrand DNA cross-links in the 5'-CpG-3' and 5'-GpC-3' sequence contexts.
Chemical research in toxicology 2009;22(11):1810-6.
2009: Kyle L Brown; Ashis K Basu; Michael P Stone
The cis-(5R,6S)-thymine glycol lesion occupies the wobble position when mismatched with deoxyguanosine in DNA.
Biochemistry 2009;48(41):9722-33.
2009: Markus Voehler; Robert L Eoff; W Hayes McDonald; F Peter Guengerich; Michael P Stone
Modulation of the structure, catalytic activity, and fidelity of African swine fever virus DNA polymerase X by a reversible disulfide switch.
The Journal of biological chemistry 2009;284(27):18434-44.
2009: Hai Huang; Hye-Young Kim; Ivan D Kozekov; Young-Jin Cho; Hao Wang; Albena Kozekova; Thomas Harris; Carmelo J Rizzo; Michael P Stone
Stereospecific formation of the (R)-gamma-hydroxytrimethylene interstrand N2-dG:N2-dG cross-link arising from the gamma-OH-1,N2-propano-2'-deoxyguanosine adduct in the 5'-CpG-3' DNA sequence.
Journal of the American Chemical Society 2009;131(24):8416-24.
2009: Irina G Minko; Ivan D Kozekov; Thomas M Harris; Carmelo J Rizzo; R Stephen Lloyd; Michael P Stone
Chemistry and biology of DNA containing 1,N(2)-deoxyguanosine adducts of the alpha,beta-unsaturated aldehydes acrolein, crotonaldehyde, and 4-hydroxynonenal.
Chemical research in toxicology 2009;22(5):759-78.
2009: Hai Huang; Hao Wang; R Stephen Lloyd; Carmelo J Rizzo; Michael P Stone
Conformational interconversion of the trans-4-hydroxynonenal-derived (6S,8R,11S) 1,N(2)-deoxyguanosine adduct when mismatched with deoxyadenosine in DNA.
Chemical research in toxicology 2009;22(1):187-200.
2008: Ganesh Shanmugam; Ivan D Kozekov; F Peter Guengerich; Carmelo J Rizzo; Michael P Stone
Structure of the 1,N2-ethenodeoxyguanosine adduct opposite cytosine in duplex DNA: Hoogsteen base pairing at pH 5.2.
Chemical research in toxicology 2008;21(9):1795-805.
2008: Hai Huang; Hao Wang; Nan Qi; Albena Kozekova; Carmelo J Rizzo; Michael P Stone
Rearrangement of the (6S,8R,11S) and (6R,8S,11R) exocyclic 1,N2-deoxyguanosine adducts of trans-4-hydroxynonenal to N2-deoxyguanosine cyclic hemiacetal adducts when placed complementary to cytosine in duplex DNA.
Journal of the American Chemical Society 2008;130(33):10898-906.
2008: Yazhen Wang; Sarah K Musser; Sam Saleh; Lawrence J Marnett; Martin Egli; Michael P Stone
Insertion of dNTPs opposite the 1,N2-propanodeoxyguanosine adduct by Sulfolobus solfataricus P2 DNA polymerase IV.
Biochemistry 2008;47(28):7322-34.
2008: Feng Wang; Feng Li; Manjori Ganguly; Luis A Marky; Barry Gold; Martin Egli; Michael P Stone
A bridging water anchors the tethered 5-(3-aminopropyl)-2'-deoxyuridine amine in the DNA major groove proximate to the N+2 C.G base pair: implications for formation of interstrand 5'-GNC-3' cross-links by nitrogen mustards.
Biochemistry 2008;47(27):7147-57.
2008: Thomas S Dexheimer; Albena Kozekova; Carmelo J Rizzo; Michael P Stone; Yves Pommier
The modulation of topoisomerase I-mediated DNA cleavage and the induction of DNA-topoisomerase I crosslinks by crotonaldehyde-derived DNA adducts.
Nucleic acids research 2008;36(12):4128-36.
2008: Yazhen Wang; Nathalie Schnetz-Boutaud; Heiko Kroth; Haruhiko Yagi; Jane M Sayer; Subodh Kumar; Donald M Jerina; Michael P Stone
3'-Intercalation of a N2-dG 1R-trans-anti-benzo[c]phenanthrene DNA adduct in an iterated (CG)3 repeat.
Chemical research in toxicology 2008;21(7):1348-58.
2008: Michael P Stone; Young-Jin Cho; Hai Huang; Hye-Young Kim; Ivan D Kozekov; Albena Kozekova; Hao Wang; Irina G Minko; R Stephen Lloyd; Thomas Harris; Carmelo J Rizzo
Interstrand DNA cross-links induced by alpha,beta-unsaturated aldehydes derived from lipid peroxidation and environmental sources.
Accounts of chemical research 2008;41(7):793-804.
2007: Ganesh Shanmugam; Angela K Goodenough; Ivan D Kozekov; F Peter Guengerich; Carmelo J Rizzo; Michael P Stone
Structure of the 1,N2-etheno-2'-deoxyguanosine adduct in duplex DNA at pH 8.6.
Chemical research in toxicology 2007;20(11):1601-11.
2007: Yazhen Wang; Nathalie Schnetz-Boutaud; Sam Saleh; Lawrence J Marnett; Michael P Stone
Bulge migration of the malondialdehyde OPdG DNA adduct when placed opposite a two-base deletion in the (CpG)3 frameshift hotspot of the Salmonella typhimurium hisD3052 gene.
Chemical research in toxicology 2007;20(8):1200-10.
2007: Feng Wang; C Eric Elmquist; James S Stover; Carmelo J Rizzo; Michael P Stone
DNA sequence modulates the conformation of the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline in the recognition sequence of the NarI restriction enzyme.
Biochemistry 2007;46(29):8498-516.
2007: Young-Jin Cho; Ivan D Kozekov; Thomas Harris; Carmelo J Rizzo; Michael P Stone
Stereochemistry modulates the stability of reduced interstrand cross-links arising from R- and S-alpha-CH3-gamma-OH-1,N2-propano-2'-deoxyguanosine in the 5'-CpG-3' DNA sequence.
Biochemistry 2007;46(10):2608-21.
2007: C Eric Elmquist; Feng Wang; James S Stover; Michael P Stone; Carmelo J Rizzo
Conformational differences of the C8-deoxyguanosine adduct of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) within the NarI recognition sequence.
Chemical research in toxicology 2007;20(3):445-54.
2007: Wen Xu; W Keither Merritt; Lubomir V Nechev; Thomas Harris; Constance M Harris; R Stephen Lloyd; Michael P Stone
Structure of the 1,4-Bis(2'-deoxyadenosin-N(6)-yl)-2S,3S-butanediol intrastrand DNA cross-link arising from butadiene diepoxide in the human N-ras codon 61 sequence.
Chemical research in toxicology 2007;20(2):187-98.
2006: Kyle L Brown; James Z Deng; Rajkumar S Iyer; Lalitha G Iyer; Markus Voehler; Michael P Stone; Constance M Harris; Thomas Harris
Unraveling the aflatoxin-FAPY conundrum: structural basis for differential replicative processing of isomeric forms of the formamidopyrimidine-type DNA adduct of aflatoxin B1.
Journal of the American Chemical Society 2006;128(47):15188-99.
2006: Markus Voehler; Galen Collier; John K Young; Michael P Stone; Markus Germann
Performance of cryogenic probes as a function of ionic strength and sample tube geometry.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2006;183(1):102-9.
2006: Feng Wang; Nicholas E DeMuro; C Eric Elmquist; James S Stover; Carmelo J Rizzo; Michael P Stone
Base-displaced intercalated structure of the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline in the recognition sequence of the NarI restriction enzyme, a hotspot for -2 bp deletions.
Journal of the American Chemical Society 2006;128(31):10085-95.
2006: Young-Jin Cho; Hao Wang; Ivan D Kozekov; Albena Kozekova; Andrew J Kurtz; Jaison Jacob; Markus Voehler; Jarrod Smith; Thomas Harris; Carmelo J Rizzo; R Stephen Lloyd; Michael P Stone
Orientation of the crotonaldehyde-derived N2-[3-Oxo-1(S)-methyl-propyl]-dG DNA adduct hinders interstrand cross-link formation in the 5'-CpG-3' sequence.
Chemical research in toxicology 2006;19(8):1019-29.
2006: Young-Jin Cho; Hao Wang; Ivan D Kozekov; Andrew J Kurtz; Jaison Jacob; Markus Voehler; Jarrod Smith; Thomas Harris; R Stephen Lloyd; Carmelo J Rizzo; Michael P Stone
Stereospecific formation of interstrand carbinolamine DNA cross-links by crotonaldehyde- and acetaldehyde-derived alpha-CH3-gamma-OH-1,N2-propano-2'-deoxyguanosine adducts in the 5'-CpG-3' sequence.
Chemical research in toxicology 2006;19(2):195-208.
2005: Young-Jin Cho; Hye-Young Kim; Hai Huang; Alvira Slutsky; Irina G Minko; Hao Wang; Lubomir V Nechev; Ivan D Kozekov; Albena Kozekova; Pamela J Tamura; Jaison Jacob; Markus Voehler; Thomas Harris; R Stephen Lloyd; Carmelo J Rizzo; Michael P Stone
Spectroscopic characterization of interstrand carbinolamine cross-links formed in the 5'-CpG-3' sequence by the acrolein-derived gamma-OH-1,N2-propano-2'-deoxyguanosine DNA adduct.
Journal of the American Chemical Society 2005;127(50):17686-96.
2005: W Keither Merritt; Lubomir V Nechev; Tandace A Scholdberg; Stephen M Dean; Sarah E Kiehna; Johanna C Chang; Thomas Harris; Constance M Harris; R Stephen Lloyd; Michael P Stone
Structure of the 1,4-bis(2'-deoxyadenosin-N6-yl)-2R,3R-butanediol cross-link arising from alkylation of the human N-ras codon 61 by butadiene diepoxide.
Biochemistry 2005;44(30):10081-92.
2005: W Keither Merritt; Agnieszka Kowalczyk; Tandace A Scholdberg; Stephen M Dean; Thomas Harris; Constance M Harris; R Stephen Lloyd; Michael P Stone
Dual roles of glycosyl torsion angle conformation and stereochemical configuration in butadiene oxide-derived N1 beta-hydroxyalkyl deoxyinosine adducts: a structural perspective.
Chemical research in toxicology 2005;18(7):1098-107.
2005: Tandace A Scholdberg; W Keither Merritt; Stephen M Dean; Agnieska Kowalcyzk; Constance M Harris; Thomas Harris; Carmelo J Rizzo; R Stephen Lloyd; Michael P Stone
Structure of an oligodeoxynucleotide containing a butadiene oxide-derived N1 beta-hydroxyalkyl deoxyinosine adduct in the human N-ras codon 61 sequence.
Biochemistry 2005;44(9):3327-37.
2005: Tandace A Scholdberg; Lubomir V Nechev; W Keither Merritt; Thomas Harris; Constance M Harris; R Stephen Lloyd; Michael P Stone
Mispairing of a site specific major groove (2S,3S)-N6-(2,3,4-trihydroxybutyl)-2'-deoxyadenosyl DNA Adduct of butadiene diol epoxide with deoxyguanosine: formation of a dA(anti).dG(anti) pairing interaction.
Chemical research in toxicology 2005;18(2):145-53.
2004: Muhammed F Hashim; James N Riggins; Nathalie Schnetz-Boutaud; Markus Voehler; Michael P Stone; Lawrence J Marnett
In vitro bypass of malondialdehyde-deoxyguanosine adducts: differential base selection during extension by the Klenow fragment of DNA polymerase I is the critical determinant of replication outcome.
Biochemistry 2004;43(37):11828-35.
2004: W Keither Merritt; Tandace A Scholdberg; Lubomir V Nechev; Thomas Harris; Constance M Harris; R Stephen Lloyd; Michael P Stone
Stereospecific structural perturbations arising from adenine N(6) butadiene triol adducts in duplex DNA.
Chemical research in toxicology 2004;17(8):1007-19.
2004: Tandace A Scholdberg; Lubomir V Nechev; W Keither Merritt; Thomas Harris; Constance M Harris; R Stephen Lloyd; Michael P Stone
Structure of a site specific major groove (2S,3S)-N6-(2,3,4-trihydroxybutyl)-2'-deoxyadenosyl DNA adduct of butadiene diol epoxide.
Chemical research in toxicology 2004;17(6):717-30.
2003: Indrajit Giri; Michael P Stone
Wobble dC.dA pairing 5' to the cationic guanine N7 8,9-dihydro-8-(N7-guanyl)-9-hydroxyaflatoxin B1 adduct: implications for nontargeted AFB1 mutagenesis.
Biochemistry 2003;42(23):7023-34.
2003: Hye-Young H Kim; Amanda S Wilkinson; Constance M Harris; Thomas Harris; Michael P Stone
Minor groove orientation for the (1S,2R,3S,4R)-N2- [1-(1,2,3,4-tetrahydro-2,3,4-trihydroxybenz[a]anthracenyl)]-2'-deoxyguanosyl adduct in the N-ras codon 12 sequence.
Biochemistry 2003;42(8):2328-38.
2003: Patricia A Dooley; Mingzhou Zhang; Gregory A Korbel; Lubomir V Nechev; Constance M Harris; Michael P Stone; Thomas Harris
NMR determination of the conformation of a trimethylene interstrand cross-link in an oligodeoxynucleotide duplex containing a 5'-d(GpC) motif.
Journal of the American Chemical Society 2003;125(1):62-72.
2003: Ivan D Kozekov; Lubomir V Nechev; M Scott Moseley; Constance M Harris; Carmelo J Rizzo; Michael P Stone; Thomas Harris
DNA interchain cross-links formed by acrolein and crotonaldehyde.
Journal of the American Chemical Society 2003;125(1):50-61.
2002: Indrajit Giri; Michael P Stone
Thermal stabilization of the DNA duplex by adducts of aflatoxin B1.
Biopolymers 2002;65(3):190-201.
2002: Hye-Young H Kim; Markus Voehler; Thomas Harris; Michael P Stone
Detection of an interchain carbinolamine cross-link formed in a CpG sequence by the acrolein DNA adduct gamma-OH-1,N( 2)-propano-2'-deoxyguanosine.
Journal of the American Chemical Society 2002;124(32):9324-5.
2002: Zhijun Li; Li Huang; Prasad Dande; Barry Gold; Michael P Stone
Structure of a tethered cationic 3-aminopropyl chain incorporated into an oligodeoxynucleotide: evidence for 3'-orientation in the major groove accompanied by DNA bending.
Journal of the American Chemical Society 2002;124(29):8553-60.
2002: Indrajit Giri; Mark D Jenkins; Nathalie Schnetz-Boutaud; Michael P Stone
Structural refinement of the 8,9-dihydro-8-(N7-guanyl)-9-hydroxy-aflatoxin B(1) adduct in a 5'-Cp(AFB)G-3' sequence.
Chemical research in toxicology 2002;15(5):638-47.
2002: Indrajit Giri; David S Johnston; Michael P Stone
Mispairing of the 8,9-dihydro-8-(N7-guanyl)-9-hydroxy-aflatoxin B1 adduct with deoxyadenosine results in extrusion of the mismatched dA toward the major groove.
Biochemistry 2002;41(17):5462-72.
2002: Jason P Weisenseel; G Ramachandra Reddy; Lawrence J Marnett; Michael P Stone
Structure of the 1,N(2)-propanodeoxyguanosine adduct in a three-base DNA hairpin loop derived from a palindrome in the Salmonella typhimurium hisD3052 gene.
Chemical research in toxicology 2002;15(2):140-52.
2002: Jason P Weisenseel; G Ramachandra Reddy; Lawrence J Marnett; Michael P Stone
Structure of an oligodeoxynucleotide containing a 1,N(2)-propanodeoxyguanosine adduct positioned in a palindrome derived from the Salmonella typhimurium hisD3052 gene: Hoogsteen pairing at pH 5.2.
Chemical research in toxicology 2002;15(2):127-39.
2001: Nathalie Schnetz-Boutaud; Sam Saleh; Lawrence J Marnett; Michael P Stone
The exocyclic 1,N2-deoxyguanosine pyrimidopurinone M1G is a chemically stable DNA adduct when placed opposite a two-base deletion in the (CpG)3 frameshift hotspot of the Salmonella typhimurium hisD3052 gene.
Biochemistry 2001;40(51):15638-49.
2001: C Hennard; JI Finneman; Constance M Harris; Thomas Harris; Michael P Stone
The nonmutagenic (R)- and (S)-beta-(N(6)-adenyl)styrene oxide adducts are oriented in the major groove and show little perturbation to DNA structure.
Biochemistry 2001;40(33):9780-91.
2001: Z Li; Pamela J Tamura; Amanda S Wilkinson; Constance M Harris; Thomas Harris; Michael P Stone
Intercalation of the (1R,2S,3R,4S)-N6-[1-(1,2,3,4-tetrahydro-2,3,4-trihydroxybenz[a]anthracenyl)]-2'-deoxyadenosyl adduct in the N-ras codon 61 sequence: DNA sequence effects.
Biochemistry 2001;40(23):6743-55.
2001: P A Dooley; D Tsarouhtsis; G A Korbel; Lubomir V Nechev; J Shearer; IS Zegar; Constance M Harris; Michael P Stone; Thomas Harris
Structural studies of an oligodeoxynucleotide containing a trimethylene interstrand cross-link in a 5'-(CpG) motif: model of a malondialdehyde cross-link.
Journal of the American Chemical Society 2001;123(8):1730-9.
2001: Nathalie Schnetz-Boutaud; Sam Saleh; Lawrence J Marnett; Michael P Stone
Structure of the malondialdehyde deoxyguanosine adduct M1G when placed opposite a two-base deletion in the (CpG)3 frameshift hotspot of the Salmonella typhimurium hisD3052 gene.
Advances in experimental medicine and biology 2001;500():513-6.
2000: David S Johnston; Michael P Stone
Replication of a site-specific trans-8,9-dihydro-8-(N7-guanyl)-9-hydroxyaflatoxin B(1) adduct by the exonuclease deficient klenow fragment of DNA polymerase I.
Chemical research in toxicology 2000;13(11):1158-64.
2000: M F Simeonov; Pamela J Tamura; Amanda S Wilkinson; Constance M Harris; Thomas Harris; Michael P Stone
Sequence- and stereospecific conformational rearrangement of styrene oxide adducts located at A x C mismatched base pairs.
Biochemistry 2000;39(5):924-37.
2000: Nathalie Schnetz-Boutaud; H Mao; Michael P Stone; Lawrence J Marnett
Synthesis of oligonucleotides containing the alkali-labile pyrimidopurinone adduct, M(1)G.
Chemical research in toxicology 2000;13(2):90-5.
2000: P T Le; Constance M Harris; Thomas Harris; Michael P Stone
Altered electrophoretic migration of polycyclic aromatic hydrocarbon and styrene oxide adducts at adenine N(6) correlates with adduct-induced structural disorder.
Chemical research in toxicology 2000;13(2):63-71.
1999: Z Li; Hye-Young H Kim; Pamela J Tamura; Constance M Harris; Thomas Harris; Michael P Stone
Intercalation of the (1S,2R,3S,4R)-N6-[1-(1,2,3,4-tetrahydro-2,3, 4-trihydroxybenz[a]anthracenyl)]-2'-deoxyadenosyl adduct in an oligodeoxynucleotide containing the human N-ras codon 61 sequence.
Biochemistry 1999;38(49):16045-57.
1999: SD Cline; WR Jones; Michael P Stone; Neil Osheroff
DNA abasic lesions in a different light: solution structure of an endogenous topoisomerase II poison.
Biochemistry 1999;38(47):15500-7.
1999: Z Li; Hye-Young H Kim; Pamela J Tamura; Constance M Harris; Thomas Harris; Michael P Stone
Role of a polycyclic aromatic hydrocarbon bay region ring in modulating DNA adduct structure: the non-bay region (8S,9R,10S, 11R)-N(6)-[11-(8,9,10,11-tetrahydro-8,9, 10-trihydroxybenz[a]anthracenyl)]-2'-deoxyadenosyl adduct in codon 61 of the human N-ras protooncogene.
Biochemistry 1999;38(45):14820-32.
1999: H Mao; G Ramachandra Reddy; Lawrence J Marnett; Michael P Stone
Solution structure of an oligodeoxynucleotide containing the malondialdehyde deoxyguanosine adduct N2-(3-oxo-1-propenyl)-dG (ring-opened M1G) positioned in a (CpG)3 frameshift hotspot of the Salmonella typhimurium hisD3052 gene.
Biochemistry 1999;38(41):13491-501.
1999: WR Jones; David S Johnston; Michael P Stone
Site-specific synthesis of aflatoxin B(1) adducts within an oligodeoxyribonucleotide containing the human p53 codon 249 sequence.
Chemical research in toxicology 1999;12(8):707-14.
1999: S L Painter; IS Zegar; Pamela J Tamura; S Bluhm; Constance M Harris; Thomas Harris; Michael P Stone
Influence of the R(61,2)- and S(61,2)-alpha-(N6-adenyl)styrene oxide adducts on the A.C mismatched base pair in an oligodeoxynucleotide containing the human N-ras codon 61.
Biochemistry 1999;38(27):8635-46.
1999: H Mao; Nathalie Schnetz-Boutaud; Jason P Weisenseel; Lawrence J Marnett; Michael P Stone
Duplex DNA catalyzes the chemical rearrangement of a malondialdehyde deoxyguanosine adduct.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(12):6615-20.
1999: Z Li; H Mao; Hye-Young H Kim; Pamela J Tamura; Constance M Harris; Thomas Harris; Michael P Stone
Intercalation of the (-)-(1R,2S,3R, 4S)-N6-[1-benz[a]anthracenyl]-2'-deoxyadenosyl adduct in an oligodeoxynucleotide containing the human N-ras codon 61 sequence.
Biochemistry 1999;38(10):2969-81.
1998: IS Zegar; P Chary; R J Jabil; Pamela J Tamura; T N Johansen; R Stephen Lloyd; Constance M Harris; Thomas Harris; Michael P Stone
Multiple conformations of an intercalated (-)-(7S,8R,9S, 10R)-N6-[10-(7,8,9,10-tetrahydrobenzo[a]pyrenyl)]-2'-deoxyadenosyl adduct in the N-ras codon 61 sequence.
Biochemistry 1998;37(47):16516-28.
1998: WR Jones; David S Johnston; Michael P Stone
Refined structure of the doubly intercalated d(TATAFBGCATA)2 aflatoxin B1 adduct.
Chemical research in toxicology 1998;11(8):873-81.
1998: F R Setayesh; B L DeCorte; P Horton; Constance M Harris; Thomas Harris; Michael P Stone
Styrene oxide adducts in an oligodeoxynucleotide containing the human N-ras codon 12: minor groove structures of the R(12,1)- and S(12,1)-alpha-(N2-guanyl) stereoisomers determined by 1H nuclear magnetic resonance.
Chemical research in toxicology 1998;11(7):766-77.
1998: H Mao; Zhengwu Deng; Feng Wang; Thomas Harris; Michael P Stone
An intercalated and thermally stable FAPY adduct of aflatoxin B1 in a DNA duplex: structural refinement from 1H NMR.
Biochemistry 1998;37(13):4374-87.
1998: WR Jones; Michael P Stone
Site-specific targeting of aflatoxin adduction directed by triple helix formation in the major groove of oligodeoxyribonucleotides.
Nucleic acids research 1998;26(4):1070-5.
1996: B Feng; M Voehler; L Zhou; M Passarelli; Constance M Harris; Thomas Harris; Michael P Stone
Major groove (S)-alpha-(N6-adenyl)styrene oxide adducts in an oligodeoxynucleotide containing the human N-ras codon 61 sequence: conformations of the S(61,2) and S(61,3) sequence isomers from 1H NMR.
Biochemistry 1996;35(23):7316-29.
1996: I S Zegar; S J Kim; T N Johansen; P J Horton; Constance M Harris; Thomas Harris; Michael P Stone
Adduction of the human N-ras codon 61 sequence with (-)-(7S,8R,9R,10S)-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a] pyrene: structural refinement of the intercalated SRSR(61,2) (-)-(7S,8R,9S,10R)-N6-[10-(7,8,9,10- tetrahydrobenzo[a]pyrenyl)]-2'-deoxyadenosyl adduct from 1H NMR.
Biochemistry 1996;35(20):6212-24.
1996: I S Zegar; F R Setayesh; B L DeCorte; Constance M Harris; Thomas Harris; Michael P Stone
Styrene oxide adducts in an oligodeoxynucleotide containing the human N-ras codon 12 sequence: structural refinement of the minor groove R(12,2)- and S(12,2)-alpha-(N2-guanyl) stereoisomers from 1H NMR.
Biochemistry 1996;35(14):4334-48.
1996: I S Zegar; Michael P Stone
Solution structure of an oligodeoxynucleotide containing the human N-ras codon 12 sequence refined from 1H NMR using molecular dynamics restrained by nuclear Overhauser effects.
Chemical research in toxicology 1996;9(1):114-25.
1995: David S Johnston; Michael P Stone
Refined solution structure of 8,9-dihydro-8-(N7-guanyl)-9-hydroxyaflatoxin B1 opposite CpA in the complementary strand of an oligodeoxynucleotide duplex as determined by 1H NMR.
Biochemistry 1995;34(43):14037-50.
1995: B Feng; L Zhou; M Passarelli; Constance M Harris; Thomas Harris; Michael P Stone
Major groove (R)-alpha-(N6-adenyl)styrene oxide adducts in an oligodeoxynucleotide containing the human N-ras codon 61 sequence: conformations of the R(61,2) and R(61,3) sequence isomers from 1H NMR.
Biochemistry 1995;34(43):14021-36.
1995: B Feng; Michael P Stone
Solution structure of an oligodeoxynucleotide containing the human n-ras codon 61 sequence refined from 1H NMR using molecular dynamics restrained by nuclear Overhauser effects.
Chemical research in toxicology 1995;8(6):821-32.
1995: Khalid A El-Sayed; A F Halim; A M Zaghloul; J D McChesney; Michael P Stone; M Voehler; K Hayashi
Pregnane glycosides from Stapelia variegata.
Phytochemistry 1995;39(2):395-403.
1995: J P Weisenseel; J G Moe; G Ramachandra Reddy; Lawrence J Marnett; Michael P Stone
Structure of a duplex oligodeoxynucleotide containing propanodeoxyguanosine opposite a two-base deletion in the (CpG)3 frame shift hotspot of Salmonella typhimurium hisD3052 determined by 1H NMR and restrained molecular dynamics.
Biochemistry 1995;34(1):50-64.
1994: J G Moe; G Ramachandra Reddy; Lawrence J Marnett; Michael P Stone
1H NMR characterization of a duplex oligodeoxynucleotide containing propanodeoxyguanosine opposite a two-base deletion in the (CpG)3 frameshift hotspot of Salmonella typhimurium hisD3052.
Chemical research in toxicology 1994;7(3):319-28.
1993: U S Singh; J G Moe; G Ramachandra Reddy; J P Weisenseel; Lawrence J Marnett; Michael P Stone
1H NMR of an oligodeoxynucleotide containing a propanodeoxyguanosine adduct positioned in a (CG)3 frameshift hotspot of Salmonella typhimurium hisD3052: Hoogsteen base-pairing at pH 5.8.
Chemical research in toxicology 1993;6(6):825-36.
1993: V M Raney; Thomas Harris; Michael P Stone
DNA conformation mediates aflatoxin B1-DNA binding and the formation of guanine N7 adducts by aflatoxin B1 8,9-exo-epoxide.
Chemical research in toxicology 1993;6(1):64-8.
1990: S Gopalakrishnan; Thomas Harris; Michael P Stone
Intercalation of aflatoxin B1 in two oligodeoxynucleotide adducts: comparative 1H NMR analysis of d(ATCAFBGAT).d(ATCGAT) and d(ATAFBGCAT)2.
Biochemistry 1990;29(46):10438-48.
1990: Kevin D Raney; S Gopalakrishnan; S Byrd; Michael P Stone; Thomas Harris
Alteration of the aflatoxin cyclopentenone ring to a delta-lactone reduces intercalation with DNA and decreases formation of guanine N7 adducts by aflatoxin epoxides.
Chemical research in toxicology 1990;3(3):254-61.
1989: T R Krugh; David E Graves; Michael P Stone
Two-dimensional NMR studies on the anthramycin-d(ATGCAT)2 adduct.
Biochemistry 1989;28(26):9988-94.
1989: S Gopalakrishnan; S Byrd; Michael P Stone; Thomas Harris
Carcinogen-nucleic acid interactions: equilibrium binding studies of aflatoxin B1 with the oligodeoxynucleotide d(ATGCAT)2 and with plasmid pBR322 support intercalative association with the B-DNA helix.
Biochemistry 1989;28(2):726-34.
1988: R J Topping; Michael P Stone; C K Brush; Thomas Harris
Non-Watson-Crick structures in oligodeoxynucleotides: self-association of d(TpCpGpA) stabilized at acidic pH.
Biochemistry 1988;27(19):7216-22.
1988: Michael P Stone; S Gopalakrishnan; Thomas Harris; David E Graves
Carcinogen-nucleic acid interactions: equilibrium binding studies of aflatoxins B1 and B2 with DNA and the oligodeoxynucleotide d(ATGCAT)2.
Journal of biomolecular structure & dynamics 1988;5(5):1025-41.
1988: Thomas Harris; Michael P Stone; Constance M Harris
Applications of NMR spectroscopy to studies of reactive intermediates and their interactions with nucleic acids.
Chemical research in toxicology 1988;1(2):79-96.
1988: C K Brush; Michael P Stone; Thomas Harris
Selective reversible deuteriation of oligodeoxynucleotides: simplification of two-dimensional nuclear Overhauser effect NMR spectral assignment of a non-self-complementary dodecamer duplex.
Biochemistry 1988;27(1):115-22.
1985: David E Graves; Michael P Stone; T R Krugh
Structure of the anthramycin-d(ATGCAT)2 adduct from one- and two-dimensional proton NMR experiments in solution.
Biochemistry 1985;24(26):7573-81.
1985: G T Walker; Michael P Stone; T R Krugh
Ethidium binding to left-handed (Z) DNAs results in regions of right-handed DNA at the intercalation site.
Biochemistry 1985;24(25):7462-71.
1985: G T Walker; Michael P Stone; T R Krugh
Interaction of drugs with Z-DNA: cooperative binding of actinomycin D or actinomine to the left-handed forms of poly(dG-dC).poly(dG-dC) and poly(dG-m5dC).poly(dG-m5dC) reverses the conformation of the helix.
Biochemistry 1985;24(25):7471-9.
1985: David E Graves; Michael P Stone; T R Krugh
NMR analysis of an oligodeoxyribonucleotide-drug adduct: anthramycin-d(ATGCAT).
Progress in clinical and biological research 1985;172B():193-205.