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Klaus Strebel

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HIV-1
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Publications

TOP 3
Amy J Andrew; Christopher E Berndsen; Sandra Kao; Klaus Strebel
The size and conservation of a coiled-coil structure in the ectodomain of human BST-2/tetherin is dispensable for inhibition of HIV-1 virion release.
Sarah Welbourn; Tommy E White; Felipe Diaz-Griffero; Eri Miyagi; Klaus Strebel
Identification and characterization of naturally occurring splice variants of SAMHD1.
Amy J Andrew; Sandra Kao; Klaus Strebel
C-terminal hydrophobic region in human bone marrow stromal cell antigen 2 (BST-2)/tetherin protein functions as second transmembrane motif.

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All Publications

2012: Amy J Andrew; Christopher E Berndsen; Sandra Kao; Klaus Strebel
The size and conservation of a coiled-coil structure in the ectodomain of human BST-2/tetherin is dispensable for inhibition of HIV-1 virion release.
The Journal of biological chemistry 2012;287(53):44278-88.
2012: Sarah Welbourn; Tommy E White; Felipe Diaz-Griffero; Eri Miyagi; Klaus Strebel
Identification and characterization of naturally occurring splice variants of SAMHD1.
Retrovirology 2012;9():86.
2011: Amy J Andrew; Sandra Kao; Klaus Strebel
C-terminal hydrophobic region in human bone marrow stromal cell antigen 2 (BST-2)/tetherin protein functions as second transmembrane motif.
The Journal of biological chemistry 2011;286(46):39967-81.
2011: Eri Miyagi; Amy Andrew; Sandra Kao; Takeshi Yoshida; Klaus Strebel
Antibody-mediated enhancement of HIV-1 and HIV-2 production from BST-2/tetherin-positive cells.
Journal of virology 2011;85(22):11981-94.
2011: Masashi Shingai; Malcolm A Martin; Takeshi Yoshida; Klaus Strebel
Some human immunodeficiency virus type 1 Vpu proteins are able to antagonize macaque BST-2 in vitro and in vivo: Vpu-negative simian-human immunodeficiency viruses are attenuated in vivo.
Journal of virology 2011;85(19):9708-15.
2011: Amy J Andrew; Eri Miyagi; Klaus Strebel
Differential effects of human immunodeficiency virus type 1 Vpu on the stability of BST-2/tetherin.
Journal of virology 2011;85(6):2611-9.
2011: Takeshi Yoshida; Sandra Kao; Klaus Strebel
Identification of Residues in the BST-2 TM Domain Important for Antagonism by HIV-1 Vpu Using a Gain-of-Function Approach.
Frontiers in microbiology 2011;2():35.
2011: Amy Andrew; Klaus Strebel
The interferon-inducible host factor bone marrow stromal antigen 2/tetherin restricts virion release, but is it actually a viral restriction factor?
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2011;31(1):137-44.
2010: Eri Miyagi; Charles R Brown; Sandrine Opi; Mohammad Khan; Ritu Goila-Gaur; Sandra Kao; Robert C Walker; Vanessa Hirsch; Klaus Strebel
Stably expressed APOBEC3F has negligible antiviral activity.
Journal of virology 2010;84(21):11067-75.
2010: Amy Andrew; Klaus Strebel
HIV-1 Vpu targets cell surface markers CD4 and BST-2 through distinct mechanisms.
Molecular aspects of medicine 2010;31(5):407-17.
2010: Javier G Magadán; F Javier Pérez-Victoria; Rachid Sougrat; Yihong Ye; Klaus Strebel; Juan Bonifacino
Multilayered mechanism of CD4 downregulation by HIV-1 Vpu involving distinct ER retention and ERAD targeting steps.
PLoS pathogens 2010;6(4):e1000869.
2010: Bradley Sanville; Michael A Dolan; Kurt Wollenberg; Yuhe Yan; Carrie Martin; Man Lung Yeung; Klaus Strebel; Alicia Buckler-White; Christine A Kozak
Adaptive evolution of Mus Apobec3 includes retroviral insertion and positive selection at two clusters of residues flanking the substrate groove.
PLoS pathogens 2010;6():e1000974.
2009: Eri Miyagi; Amy J Andrew; Sandra Kao; Klaus Strebel
Vpu enhances HIV-1 virus release in the absence of Bst-2 cell surface down-modulation and intracellular depletion.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(8):2868-73.
2009: Mohammad Khan; Ritu Goila-Gaur; Sandra Kao; Eri Miyagi; Robert C Walker; Klaus Strebel
Encapsidation of APOBEC3G into HIV-1 virions involves lipid raft association and does not correlate with APOBEC3G oligomerization.
Retrovirology 2009;6():99.
2009: Klaus Strebel; Jeremy Luban; Kuan-Teh Jeang
Human cellular restriction factors that target HIV-1 replication.
BMC medicine 2009;7():48.
2009: Amy J Andrew; Eri Miyagi; Sandra Kao; Klaus Strebel
The formation of cysteine-linked dimers of BST-2/tetherin is important for inhibition of HIV-1 virus release but not for sensitivity to Vpu.
Retrovirology 2009;6():80.
2009: Ritu Goila-Gaur; Mohammad Khan; Eri Miyagi; Klaus Strebel
Differential sensitivity of "old" versus "new" APOBEC3G to human immunodeficiency virus type 1 vif.
Journal of virology 2009;83(2):1156-60.
2008: Koichi Watashi; Mohammad Khan; Venkat R K Yedavalli; Man Lung Yeung; Klaus Strebel; Kuan-Teh Jeang
Human immunodeficiency virus type 1 replication and regulation of APOBEC3G by peptidyl prolyl isomerase Pin1.
Journal of virology 2008;82(20):9928-36.
2008: Eri Miyagi; Franziska Schwartzkopff; Ronald Plishka; Alicia Buckler-White; Kathleen A Clouse; Klaus Strebel
APOBEC3G-independent reduction in virion infectivity during long-term HIV-1 replication in terminally differentiated macrophages.
Virology 2008;379(2):266-74.
2008: Ritu Goila-Gaur; Mohammad Khan; Eri Miyagi; Sandra Kao; Sandrine Opi; Hiroaki Takeuchi; Klaus Strebel
HIV-1 Vif promotes the formation of high molecular mass APOBEC3G complexes.
Virology 2008;372(1):136-46.
2008: Klaus Strebel; Mohammad Khan
APOBEC3G encapsidation into HIV-1 virions: which RNA is it?
Retrovirology 2008;5():55.
2008: Ritu Goila-Gaur; Klaus Strebel
HIV-1 Vif, APOBEC, and intrinsic immunity.
Retrovirology 2008;5():51.
2007: Sandra Kao; Ritu Goila-Gaur; Eri Miyagi; Mohammad Khan; Sandrine Opi; Hiroaki Takeuchi; Klaus Strebel
Production of infectious virus and degradation of APOBEC3G are separable functional properties of human immunodeficiency virus type 1 Vif.
Virology 2007;369(2):329-39.
2007: Eri Miyagi; Sandrine Opi; Hiroaki Takeuchi; Mohammad Khan; Ritu Goila-Gaur; Sandra Kao; Klaus Strebel
Enzymatically active APOBEC3G is required for efficient inhibition of human immunodeficiency virus type 1.
Journal of virology 2007;81(24):13346-53.
2007: Hiroaki Takeuchi; Alicia Buckler-White; Ritu Goila-Gaur; Eri Miyagi; Mohammad Khan; Sandrine Opi; Sandra Kao; Elena Sokolskaja; Thomas Pertel; Jeremy Luban; Klaus Strebel
Vif counteracts a cyclophilin A-imposed inhibition of simian immunodeficiency viruses in human cells.
Journal of virology 2007;81(15):8080-90.
2007: Sandrine Opi; Sandra Kao; Ritu Goila-Gaur; Mohammad Khan; Eri Miyagi; Hiroaki Takeuchi; Klaus Strebel
Human immunodeficiency virus type 1 Vif inhibits packaging and antiviral activity of a degradation-resistant APOBEC3G variant.
Journal of virology 2007;81(15):8236-46.
2007: Ritu Goila-Gaur; Mohammad Khan; Eri Miyagi; Sandra Kao; Klaus Strebel
Targeting APOBEC3A to the viral nucleoprotein complex confers antiviral activity.
Retrovirology 2007;4():61.
2007: Mohammad Khan; Ritu Goila-Gaur; Sandrine Opi; Eri Miyagi; Hiroaki Takeuchi; Sandra Kao; Klaus Strebel
Analysis of the contribution of cellular and viral RNA to the packaging of APOBEC3G into HIV-1 virions.
Retrovirology 2007;4():48.
2007: Klaus Strebel
HIV accessory genes Vif and Vpu.
Advances in pharmacology (San Diego, Calif.) 2007;55():199-232.
2006: Yasumasa Iwatani; Hiroaki Takeuchi; Klaus Strebel; Judith G Levin
Biochemical activities of highly purified, catalytically active human APOBEC3G: correlation with antiviral effect.
Journal of virology 2006;80(12):5992-6002.
2006: Sandrine Opi; Hiroaki Takeuchi; Sandra Kao; Mohammad Khan; Eri Miyagi; Ritu Goila-Gaur; Yasumasa Iwatani; Judith G Levin; Klaus Strebel
Monomeric APOBEC3G is catalytically active and has antiviral activity.
Journal of virology 2006;80(10):4673-82.
2005: Mohammad Khan; Sandra Kao; Eri Miyagi; Hiroaki Takeuchi; Ritu Goila-Gaur; Sandrine Opi; Clay L Gipson; Tristam PARSLOW; Hinh Ly; Klaus Strebel
Viral RNA is required for the association of APOBEC3G with human immunodeficiency virus type 1 nucleoprotein complexes.
Journal of virology 2005;79(9):5870-4.
2005: Hiroaki Takeuchi; Sandra Kao; Eri Miyagi; Mohammad Khan; Alicia Buckler-White; Ronald Plishka; Klaus Strebel
Production of infectious SIVagm from human cells requires functional inactivation but not viral exclusion of human APOBEC3G.
The Journal of biological chemistry 2005;280(1):375-82.
2005: Klaus Strebel
APOBEC3G & HTLV-1: inhibition without deamination.
Retrovirology 2005;2():37.
2004: Mikako Fujita; Hirofumi Akari; Akiko Sakurai; Akiko Yoshida; Tomoki Chiba; Keiji Tanaka; Klaus Strebel; Akio Adachi
Expression of HIV-1 accessory protein Vif is controlled uniquely to be low and optimal by proteasome degradation.
Microbes and infection / Institut Pasteur 2004;6(9):791-8.
2004: Klaus Strebel
HIV-1 Vpu: putting a channel to the TASK.
Molecular cell 2004;14(2):150-2.
2004: Hirofumi Akari; Mikako Fujita; Sandra Kao; Mohammad Khan; Miranda Shehu-Xhilaga; Akio Adachi; Klaus Strebel
High level expression of human immunodeficiency virus type-1 Vif inhibits viral infectivity by modulating proteolytic processing of the Gag precursor at the p2/nucleocapsid processing site.
The Journal of biological chemistry 2004;279(13):12355-62.
2004: Kim-Lien Nguyen; Manuel Llano; Hirofumi Akari; Eri Miyagi; Eric M Poeschla; Klaus Strebel; Stephan Bour
Codon optimization of the HIV-1 vpu and vif genes stabilizes their mRNA and allows for highly efficient Rev-independent expression.
Virology 2004;319(2):163-75.
2004: Sandra Kao; Eri Miyagi; Mohammad Khan; Hiroaki Takeuchi; Sandrine Opi; Ritu Goila-Gaur; Klaus Strebel
Production of infectious human immunodeficiency virus type 1 does not require depletion of APOBEC3G from virus-producing cells.
Retrovirology 2004;1():27.
2003: Vasundhara Varthakavi; Rita M Smith; Stephan Bour; Klaus Strebel; Paul Spearman
Viral protein U counteracts a human host cell restriction that inhibits HIV-1 particle production.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(25):15154-9.
2003: Sandra Kao; Mohammad Khan; Eri Miyagi; Ronald Plishka; Alicia Buckler-White; Klaus Strebel
The human immunodeficiency virus type 1 Vif protein reduces intracellular expression and inhibits packaging of APOBEC3G (CEM15), a cellular inhibitor of virus infectivity.
Journal of virology 2003;77(21):11398-407.
2003: Stephan Bour; Klaus Strebel
The HIV-1 Vpu protein: a multifunctional enhancer of viral particle release.
Microbes and infection / Institut Pasteur 2003;5(11):1029-39.
2003: Stephan Bour; Hirofumi Akari; Eri Miyagi; Klaus Strebel
Naturally occurring amino acid substitutions in the HIV-2 ROD envelope glycoprotein regulate its ability to augment viral particle release.
Virology 2003;309(1):85-98.
2003: Klaus Strebel
Virus-host interactions: role of HIV proteins Vif, Tat, and Rev.
AIDS (London, England) 2003;17 Suppl 4():S25-34.
2003: Sandra Kao; Hirofumi Akari; Mohammad Khan; Markus Dettenhofer; XIAOFANG YU; Klaus Strebel
Human immunodeficiency virus type 1 Vif is efficiently packaged into virions during productive but not chronic infection.
Journal of virology 2003;77(2):1131-40.
2002: Mohammad Khan; Hirofumi Akari; Sandra Kao; Claudia Aberham; David Davis; Alicia Buckler-White; Klaus Strebel
Intravirion processing of the human immunodeficiency virus type 1 Vif protein by the viral protease may be correlated with Vif function.
Journal of virology 2002;76(18):9112-23.
2002: Che Ma; Francesca M Marassi; David H Jones; Suzana K Straus; Stephan Bour; Klaus Strebel; Ulrich Schubert; Myrta Oblatt-Montal; Mauricio Montal; Stanley J Opella
Expression, purification, and activities of full-length and truncated versions of the integral membrane protein Vpu from HIV-1.
Protein science : a publication of the Protein Society 2002;11(3):546-57.
2001: Hirofumi Akari; Stephan Bour; Sandra Kao; A Adachi; Klaus Strebel
The human immunodeficiency virus type 1 accessory protein Vpu induces apoptosis by suppressing the nuclear factor kappaB-dependent expression of antiapoptotic factors.
The Journal of experimental medicine 2001;194(9):1299-311.
2001: Mohammad Khan; Claudia Aberham; Sandra Kao; Hirofumi Akari; R Gorelick; Stephan Bour; Klaus Strebel
Human immunodeficiency virus type 1 Vif protein is packaged into the nucleoprotein complex through an interaction with viral genomic RNA.
Journal of virology 2001;75(16):7252-65.
2001: Stephan Bour; C Perrin; Hirofumi Akari; Klaus Strebel
The human immunodeficiency virus type 1 Vpu protein inhibits NF-kappa B activation by interfering with beta TrCP-mediated degradation of Ikappa B.
The Journal of biological chemistry 2001;276(19):15920-8.
2000: Hirofumi Akari; S Arold; T Fukumori; T Okazaki; Klaus Strebel; Akio Adachi
Nef-induced major histocompatibility complex class I down-regulation is functionally dissociated from its virion incorporation, enhancement of viral infectivity, and CD4 down-regulation.
Journal of virology 2000;74(6):2907-12.
2000: Stephan Bour; Klaus Strebel
HIV accessory proteins: multifunctional components of a complex system.
Advances in pharmacology (San Diego, Calif.) 2000;48():75-120.
1999: Francesca M Marassi; Che Ma; Holly Gratkowski; Suzana K Straus; Klaus Strebel; Myrta Oblatt-Montal; Mauricio Montal; Stanley J Opella
Correlation of the structural and functional domains in the membrane protein Vpu from HIV-1.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(25):14336-41.
1999: Stephan Bour; C Perrin; Klaus Strebel
Cell surface CD4 inhibits HIV-1 particle release by interfering with Vpu activity.
The Journal of biological chemistry 1999;274(47):33800-6.
1999: Z Lin; Nouri Neamati; Hong Zhao; Y Kiryu; Jim A Turpin; Claudia Aberham; Klaus Strebel; Kurt W Kohn; M Witvrouw; C Pannecouque; zeger debyser; E De Clercq; William G Rice; Yves Pommier; Terrence R Burke
Chicoric acid analogues as HIV-1 integrase inhibitors.
Journal of medicinal chemistry 1999;42(8):1401-14.
1999: Ulrich Schubert; Stephan Bour; Ronald L Willey; Klaus Strebel
Regulation of virus release by the macrophage-tropic human immunodeficiency virus type 1 AD8 isolate is redundant and can be controlled by either Vpu or Env.
Journal of virology 1999;73(2):887-96.
1999: Klaus Strebel; Stephan Bour
Molecular interactions of HIV with host factors.
AIDS (London, England) 1999;13 Suppl A():S13-24.
1999: Stephan Bour; Claudia Aberham; C Perrin; Klaus Strebel
Lack of effect of cytoplasmic tail truncations on human immunodeficiency virus type 2 ROD env particle release activity.
Journal of virology 1999;73(1):778-82.
1998: F Margottin; Stephan Bour; H Durand; L Selig; Serge Benichou; V Richard; D Thomas; Klaus Strebel; Richard Benarous
A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif.
Molecular cell 1998;1(4):565-74.
1998: Ulrich Schubert; Luis Anton; I Bacík; J H Cox; Stephan Bour; Jack R Bennink; Marian Orlowski; Klaus Strebel; jon yewdell
CD4 glycoprotein degradation induced by human immunodeficiency virus type 1 Vpu protein requires the function of proteasomes and the ubiquitin-conjugating pathway.
Journal of virology 1998;72(3):2280-8.
1996: Stephan Bour; Klaus Strebel
The human immunodeficiency virus (HIV) type 2 envelope protein is a functional complement to HIV type 1 Vpu that enhances particle release of heterologous retroviruses.
Journal of virology 1996;70(12):8285-300.
1996: Ulrich Schubert; A V Ferrer-Montiel; Myrta Oblatt-Montal; P Henklein; Klaus Strebel; Mauricio Montal
Identification of an ion channel activity of the Vpu transmembrane domain and its involvement in the regulation of virus release from HIV-1-infected cells.
FEBS letters 1996;398(1):12-8.
1996: Stephan Bour; Ulrich Schubert; Keith W C Peden; Klaus Strebel
The envelope glycoprotein of human immunodeficiency virus type 2 enhances viral particle release: a Vpu-like factor?
Journal of virology 1996;70(2):820-9.
1996: Ulrich Schubert; Stephan Bour; A V Ferrer-Montiel; Mauricio Montal; F Maldarell; Klaus Strebel
The two biological activities of human immunodeficiency virus type 1 Vpu protein involve two separable structural domains.
Journal of virology 1996;70(2):809-19.
1996: M K Karczewski; Klaus Strebel
Cytoskeleton association and virion incorporation of the human immunodeficiency virus type 1 Vif protein.
Journal of virology 1996;70(1):494-507.
1995: Ulrich Schubert; Kathleen A Clouse; Klaus Strebel
Augmentation of virus secretion by the human immunodeficiency virus type 1 Vpu protein is cell type independent and occurs in cultured human primary macrophages and lymphocytes.
Journal of virology 1995;69(12):7699-711.
1995: Stephan Bour; Ulrich Schubert; Klaus Strebel
The human immunodeficiency virus type 1 Vpu protein specifically binds to the cytoplasmic domain of CD4: implications for the mechanism of degradation.
Journal of virology 1995;69(3):1510-20.
1994: Ulrich Schubert; Klaus Strebel
Differential activities of the human immunodeficiency virus type 1-encoded Vpu protein are regulated by phosphorylation and occur in different cellular compartments.
Journal of virology 1994;68(4):2260-71.
1994: Ulrich Schubert; P Henklein; B Boldyreff; Edgar Wingender; Klaus Strebel; T Porstmann
The human immunodeficiency virus type 1 encoded Vpu protein is phosphorylated by casein kinase-2 (CK-2) at positions Ser52 and Ser56 within a predicted alpha-helix-turn-alpha-helix-motif.
Journal of molecular biology 1994;236(1):16-25.
1994: R L Willey; Alicia Buckler-White; Klaus Strebel
Sequences present in the cytoplasmic domain of CD4 are necessary and sufficient to confer sensitivity to the human immunodeficiency virus type 1 Vpu protein.
Journal of virology 1994;68(2):1207-12.
1993: Frank Maldarelli; M Y Chen; R L Willey; Klaus Strebel
Human immunodeficiency virus type 1 Vpu protein is an oligomeric type I integral membrane protein.
Journal of virology 1993;67(8):5056-61.
1993: M Y Chen; Frank Maldarelli; M K Karczewski; R L Willey; Klaus Strebel
Human immunodeficiency virus type 1 Vpu protein induces degradation of CD4 in vitro: the cytoplasmic domain of CD4 contributes to Vpu sensitivity.
Journal of virology 1993;67(7):3877-84.
1993: T Kevin Howcroft; Klaus Strebel; Malcolm Martin; dinah singer
Repression of MHC class I gene promoter activity by two-exon Tat of HIV.
Science (New York, N.Y.) 1993;260(5112):1320-2.
1992: R L Willey; Frank Maldarelli; Malcolm Martin; Klaus Strebel
Human immunodeficiency virus type 1 Vpu protein induces rapid degradation of CD4.
Journal of virology 1992;66(12):7193-200.
1992: R L Willey; Frank Maldarelli; Malcolm Martin; Klaus Strebel
Human immunodeficiency virus type 1 Vpu protein regulates the formation of intracellular gp160-CD4 complexes.
Journal of virology 1992;66(1):226-34.
1991: Frank Maldarelli; Malcolm Martin; Klaus Strebel
Identification of posttranscriptionally active inhibitory sequences in human immunodeficiency virus type 1 RNA: novel level of gene regulation.
Journal of virology 1991;65(11):5732-43.
1990: Thomas Klimkait; Klaus Strebel; M D Hoggan; Malcolm Martin; J M Orenstein
The human immunodeficiency virus type 1-specific protein vpu is required for efficient virus maturation and release.
Journal of virology 1990;64(2):621-9.
1989: Klaus Strebel; Thomas Klimkait; Frank Maldarelli; Malcolm Martin
Molecular and biochemical analyses of human immunodeficiency virus type 1 vpu protein.
Journal of virology 1989;63(9):3784-91.
1989: F Clavel; M D Hoggan; R L Willey; Klaus Strebel; Malcolm Martin; R Repaske
Genetic recombination of human immunodeficiency virus.
Journal of virology 1989;63(3):1455-9.
1989: Kathleen A Clouse; D Powell; I Washington; G Poli; Klaus Strebel; W Farrar; P Barstad; J Kovacs; Anthony Fauci; Thomas M Folks
Monokine regulation of human immunodeficiency virus-1 expression in a chronically infected human T cell clone.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(2):431-8.
1988: Klaus Strebel; Thomas Klimkait; Malcolm Martin
A novel gene of HIV-1, vpu, and its 16-kilodalton product.
Science (New York, N.Y.) 1988;241(4870):1221-3.