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Jörg Striessnig

Research Profile

Chemicals & Drugs

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Physiology

Ion Channel Gating

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Stefan T Kaehler; Julia Kirchebner; Peter Marschang; Anna E Purtscher; Anna Ratt; Harald Schennach; Christine Scherer; Markus Anliker; Holger Baumgartner; Anna C Colvin; Jennifer Falk; Astrid Gasser; Andrea Griesmacher; Martina Jeske; Jörg Striessnig
Prevalence of hypovitaminosis D and folate deficiency in healthy young female Austrian students in a health care profession.
Bohumila Jurkovičová-Tarabová; Désirée Griesemer; Antonella Pirone; Martina J Sinnegger-Brauns; Jörg Striessnig; Eckhard Friauf
Repertoire of high voltage-activated Ca2+ channels in the lateral superior olive: functional analysis in wild-type, Ca(v)1.3(-/-), and Ca(v)1.2DHP(-/-) mice.
Andreas Lieb; Simone Sartori; Anja Scharinger; martina Sinnegger-Brauns; Jörg Striessnig
Structural determinants of CaV1.3 L-type calcium channel gating.

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2012: Stefan T Kaehler; Julia Kirchebner; Peter Marschang; Anna E Purtscher; Anna Ratt; Harald Schennach; Christine Scherer; Markus Anliker; Holger Baumgartner; Anna C Colvin; Jennifer Falk; Astrid Gasser; Andrea Griesmacher; Martina Jeske; Jörg Striessnig
Prevalence of hypovitaminosis D and folate deficiency in healthy young female Austrian students in a health care profession.
European journal of nutrition 2012;51(8):1021-31.
2012: Bohumila Jurkovičová-Tarabová; Désirée Griesemer; Antonella Pirone; Martina J Sinnegger-Brauns; Jörg Striessnig; Eckhard Friauf
Repertoire of high voltage-activated Ca2+ channels in the lateral superior olive: functional analysis in wild-type, Ca(v)1.3(-/-), and Ca(v)1.2DHP(-/-) mice.
Journal of neurophysiology 2012;108(2):365-79.
2012: Andreas Lieb; Simone Sartori; Anja Scharinger; martina Sinnegger-Brauns; Jörg Striessnig
Structural determinants of CaV1.3 L-type calcium channel gating.
Channels (Austin, Tex.) 2012;6(3):197-205.
2011: Gabriella Bock; Perrine Busquet; Mathias Gebhart; Stefan Herzig; Wanchana Jangsangthong; Matteo E Mangoni; Chiara Poggiani; Simone Sartori; Anja Scharinger; martina Sinnegger-Brauns; Jörg Striessnig; alexandra koschak
Functional properties of a newly identified C-terminal splice variant of Cav1.3 L-type Ca2+ channels.
The Journal of biological chemistry 2011;286(49):42736-48.
2011: Jan J Hirtz; Michael Boesen; Nadine Braun; Joachim W Deitmer; Florian Kramer; Christian Lohr; Britta Müller; Hans Gerd Nothwang; Jörg Striessnig; Stefan Löhrke; Eckhard Friauf
Cav1.3 calcium channels are required for normal development of the auditory brainstem.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(22):8280-94.
2011: Satyajit Mahapatra; andrea marcantoni; Jörg Striessnig; David H Vandael; Emilio Carbone
Are Ca(v)1.3 pacemaker channels in chromaffin cells? Possible bias from resting cell conditions and DHP blockers usage.
Channels (Austin, Tex.) 2011;5(3):219-24.
2011: Laurine Marger; Pietro Mesirca; Joël Nargeot; Hee-Sup Shin; Jörg Striessnig; Angelo Torrente; Jacqueline Alig; Stefan Dubel; Heimo Ehmke; Birgit Engeland; Pierre Fontanaud; Dirk Isbrandt; Sandra Kanani; Matteo E Mangoni
Functional roles of Ca(v)1.3, Ca(v)3.1 and HCN channels in automaticity of mouse atrioventricular cells: insights into the atrioventricular pacemaker mechanism.
Channels (Austin, Tex.) 2011;5(3):251-61.
2011: Laurine Marger; Pietro Mesirca; Joël Nargeot; Hee-Sup Shin; Jörg Striessnig; Angelo Torrente; Jacqueline Alig; Stefan Dubel; Heimo Ehmke; Birgit Engeland; Pierre Fontanaud; Dirk Isbrandt; Sandra Kanani; Matteo E Mangoni
Pacemaker activity and ionic currents in mouse atrioventricular node cells.
Channels (Austin, Tex.) 2011;5(3):241-50.
2011: Shahid M Baig; alexandra koschak; Andreas Lieb; Mathias Gebhart; Claudia Dafinger; Gudrun Nürnberg; Amjad Ali; Ilyas Ahmad; Martina J Sinnegger-Brauns; Niels Brandt; Jutta Engel; Matteo E Mangoni; Muhammad Farooq; Habib U Khan; Peter Nürnberg; Jörg Striessnig; Hanno J Bolz
Loss of Ca(v)1.3 (CACNA1D) function in a human channelopathy with bradycardia and congenital deafness.
Nature neuroscience 2011;14(1):77-84.
2010: Catrin Swantje Müller; Alexander Haupt; Wolfgang Bildl; Jens Schindler; Hans-Günther Knaus; Marcel Meissner; Burkhard Rammner; Jörg Striessnig; Veit Flockerzi; Bernd Fakler; Uwe Schulte
Quantitative proteomics of the Cav2 channel nano-environments in the mammalian brain.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(34):14950-7.
2010: Mathias Gebhart; Gabriella Juhasz-Vedres; Annalisa Zuccotti; Niels Brandt; Jutta Engel; Alexander Trockenbacher; Gurjot Kaur; Gerald Obermair; Marlies Knipper; alexandra koschak; Jörg Striessnig
Modulation of Cav1.3 Ca2+ channel gating by Rab3 interacting molecule.
Molecular and cellular neurosciences 2010;44(3):246-59.
2010: Jörg Striessnig; Hanno Jörn Bolz; alexandra koschak
Channelopathies in Cav1.1, Cav1.3, and Cav1.4 voltage-gated L-type Ca2+ channels.
Pflügers Archiv : European journal of physiology 2010;460(2):361-74.
2010: Perrine Busquet; Ngoc Khoi Nguyen; Eduard Schmid; Naoyuki Tanimoto; Mathias W Seeliger; Tamar Ben-Yosef; Fengxia Mizuno; Abram Akopian; Jörg Striessnig; Nicolas Singewald
CaV1.3 L-type Ca2+ channels modulate depression-like behaviour in mice independent of deaf phenotype.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2010;13(4):499-513.
2009: Jörg Striessnig
An oily competition: role of beta subunit palmitoylation for Ca2+ channel modulation by fatty acids.
The Journal of general physiology 2009;134(5):363-7.
2009: Prakash Subramanyam; Gerald Obermair; Sabine Baumgartner; Mathias Gebhart; Jörg Striessnig; Walter A Kaufmann; Stephan Geley; Bernhard E Flucher
Activity and calcium regulate nuclear targeting of the calcium channel beta4b subunit in nerve and muscle cells.
Channels (Austin, Tex.) 2009;3(5):343-55.
2009: Silja Horak; alexandra koschak; Hermann Stuppner; Jörg Striessnig
Use-dependent block of voltage-gated Cav2.1 Ca2+ channels by petasins and eudesmol isomers.
The Journal of pharmacology and experimental therapeutics 2009;330(1):220-6.
2009: Sergio Bova; Simona Saponara; Angela Rampa; Silvia Gobbi; Lorenzo Cima; Fabio Fusi; Giampietro Sgaragli; Maurizio Cavalli; Cristobal de los Rios; Jörg Striessnig; Alessandra Bisi
Anthracene based compounds as new L-type Ca2+ channel blockers: design, synthesis, and full biological profile.
Journal of medicinal chemistry 2009;52(5):1259-62.
2009: martina Sinnegger-Brauns; Irene G Huber; alexandra koschak; Claudia Wild; Gerald Obermair; Ursula Einzinger; Jean-Charles Hoda; Simone B Sartori; Jörg Striessnig
Expression and 1,4-dihydropyridine-binding properties of brain L-type calcium channel isoforms.
Molecular pharmacology 2009;75(2):407-14.
2008: Katrin Watschinger; Silja B Horak; Katrin Schulze; Gerald Obermair; Claudia Wild; alexandra koschak; Martina J Sinnegger-Brauns; Robert Tampé; Jörg Striessnig
Functional properties and modulation of extracellular epitope-tagged Ca(V)2.1 voltage-gated calcium channels.
Channels (Austin, Tex.) 2008;2(6):461-73.
2008: Anamika Singh; Mathias Gebhart; Reinhard Fritsch; martina Sinnegger-Brauns; Chiara Poggiani; Jean-Charles Hoda; Jutta Engel; Christoph Romanin; Jörg Striessnig; alexandra koschak
Modulation of voltage- and Ca2+-dependent gating of CaV1.3 L-type calcium channels by alternative splicing of a C-terminal regulatory domain.
The Journal of biological chemistry 2008;283(30):20733-44.
2008: Jörg Striessnig; alexandra koschak
Exploring the function and pharmacotherapeutic potential of voltage-gated Ca2+ channels with gene knockout models.
Channels (Austin, Tex.) 2008;2(4):233-51.
2008: Perrine Busquet; Alfred Hetzenauer; martina Sinnegger-Brauns; Jörg Striessnig; Nicolas Singewald
Role of L-type Ca2+ channel isoforms in the extinction of conditioned fear.
Learning & memory (Cold Spring Harbor, N.Y.) 2008;15(5):378-86.
2008: Alexandre Mezghrani; Monteil Arnaud; Katrin Watschinger; martina Sinnegger-Brauns; Christian Barrère; Emmanuel Bourinet; Joël Nargeot; Jörg Striessnig; Philippe Lory
A destructive interaction mechanism accounts for dominant-negative effects of misfolded mutants of voltage-gated calcium channels.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(17):4501-11.
2008: Jan Hendrich; Alexandra Tran Van Minh; Fay Heblich; Manuela Nieto-Rostro; Katrin Watschinger; Jörg Striessnig; Jack Wratten; Anthony Davies; Annette C Dolphin
Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(9):3628-33.
2007: Jörg Striessnig
C-terminal tailoring of L-type calcium channel function.
The Journal of physiology 2007;585(Pt 3):643-4.
2007: Manuel F Navedo; Gregory C Amberg; Ruth E Westenbroek; martina Sinnegger-Brauns; William A Catterall; Jörg Striessnig; Luis F Santana
Ca(v)1.3 channels produce persistent calcium sparklets, but Ca(v)1.2 channels are responsible for sparklets in mouse arterial smooth muscle.
American journal of physiology. Heart and circulatory physiology 2007;293(3):H1359-70.
2007: Jiang Wu; Alan D Marmorstein; Jörg Striessnig; Neal S Peachey
Voltage-dependent calcium channel CaV1.3 subunits regulate the light peak of the electroretinogram.
Journal of neurophysiology 2007;97(5):3731-5.
2007: alexandra koschak; Gerald Obermair; Francesca Pivotto; martina Sinnegger-Brauns; Jörg Striessnig; Daniela Pietrobon
Molecular nature of anomalous L-type calcium channels in mouse cerebellar granule cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(14):3855-63.
2007: Emilio Erazo-Fischer; Jörg Striessnig; Holger Taschenberger
The role of physiological afferent nerve activity during in vivo maturation of the calyx of Held synapse.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(7):1725-37.
2007: Jin Zhang; Roberto Berra-Romani; martina Sinnegger-Brauns; Jörg Striessnig; Mordecai P Blaustein; Donald R Matteson
Role of Cav1.2 L-type Ca2+ channels in vascular tone: effects of nifedipine and Mg2+.
American journal of physiology. Heart and circulatory physiology 2007;292(1):H415-25.
2006: Jörg Striessnig; alexandra koschak; martina Sinnegger-Brauns; Alfred Hetzenauer; N K Nguyen; P Busquet; G Pelster; Nicolas Singewald
Role of voltage-gated L-type Ca2+ channel isoforms for brain function.
Biochemical Society transactions 2006;34(Pt 5):903-9.
2006: Anamika Singh; Daniel Hamedinger; Jean-Charles Hoda; Mathias Gebhart; alexandra koschak; Christoph Romanin; Jörg Striessnig
C-terminal modulator controls Ca2+-dependent gating of Ca(v)1.4 L-type Ca2+ channels.
Nature neuroscience 2006;9(9):1108-16.
2006: Jean-Charles Hoda; Francesca Zaghetto; Anamika Singh; alexandra koschak; Jörg Striessnig
Effects of congenital stationary night blindness type 2 mutations R508Q and L1364H on Cav1.4 L-type Ca2+ channel function and expression.
Journal of neurochemistry 2006;96(6):1648-58.
2006: Alfred Hetzenauer; martina Sinnegger-Brauns; Jörg Striessnig; Nicolas Singewald
Brain activation pattern induced by stimulation of L-type Ca2+-channels: contribution of Ca(V)1.3 and Ca(V)1.2 isoforms.
Neuroscience 2006;139(3):1005-15.
2006: Matteo E Mangoni; Brigitte Couette; Laurine Marger; Emmanuel Bourinet; Jörg Striessnig; Joël Nargeot
Voltage-dependent calcium channels and cardiac pacemaker activity: from ionic currents to genes.
Progress in biophysics and molecular biology 2006;90(1-3):38-63.
2005: William A Catterall; Edward Perez-Reyes; Terrance P Snutch; Jörg Striessnig
International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.
Pharmacological reviews 2005;57(4):411-25.
2005: Ariana Hemara-Wahanui; Stanislav Berjukow; Carolyn I Hope; Peter K Dearden; Shu-Biao Wu; Jane Wilson-Wheeler; Dianne M Sharp; Patricia Lundon-Treweek; Gillian M Clover; Jean-Charles Hoda; Jörg Striessnig; Rainer Marksteiner; Steffen Hering; Marion A Maw
A CACNA1F mutation identified in an X-linked retinal disorder shifts the voltage dependence of Cav1.4 channel activation.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(21):7553-8.
2005: Jean-Charles Hoda; Francesca Zaghetto; alexandra koschak; Jörg Striessnig
Congenital stationary night blindness type 2 mutations S229P, G369D, L1068P, and W1440X alter channel gating or functional expression of Ca(v)1.4 L-type Ca2+ channels.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(1):252-9.
2004: Irene G Huber; Edwin Wappl-Kornherr; martina Sinnegger-Brauns; Jean-Charles Hoda; Doris Walter-Bastl; Jörg Striessnig
Opposite effects of a single IIIS5 mutation on phenylalkylamine and dihydropyridine interaction with L-type Ca2+ channels.
The Journal of biological chemistry 2004;279(53):55211-7.
2004: Carmen Müllner; Ludo A M Broos; Arn van den Maagdenberg; Jörg Striessnig
Familial hemiplegic migraine type 1 mutations K1336E, W1684R, and V1696I alter Cav2.1 Ca2+ channel gating: evidence for beta-subunit isoform-specific effects.
The Journal of biological chemistry 2004;279(50):51844-50.
2004: Jörg Striessnig; Jean-Charles Hoda; alexandra koschak; Francesca Zaghetto; Carmen Müllner; martina Sinnegger-Brauns; Claudia Wild; Katrin Watschinger; Alexander Trockenbacher; Gilda Pelster
L-type Ca2+ channels in Ca2+ channelopathies.
Biochemical and biophysical research communications 2004;322(4):1341-6.
2004: Gerlinde Kugler; Manfred Grabner; Josef Platzer; Jörg Striessnig; Bernhard E Flucher
The monoclonal antibody mAB 1A binds to the excitation--contraction coupling domain in the II-III loop of the skeletal muscle calcium channel alpha(1S) subunit.
Archives of biochemistry and biophysics 2004;427(1):91-100.
2004: Jan Matthes; Leyla Yildirim; Georg Wietzorrek; Daniel Reimer; Jörg Striessnig; Stefan Herzig
Disturbed atrio-ventricular conduction and normal contractile function in isolated hearts from Cav1.3-knockout mice.
Naunyn-Schmiedeberg's archives of pharmacology 2004;369(6):554-62.
2003: Marcus Michna; Martina Knirsch; Jean-Charles Hoda; Stefan Muenkner; Patricia Langer; Josef Platzer; Jörg Striessnig; Jutta Engel
Cav1.3 (alpha1D) Ca2+ currents in neonatal outer hair cells of mice.
The Journal of physiology 2003;553(Pt 3):747-58.
2003: William A Catterall; Jörg Striessnig; Terrance P Snutch; Edward Perez-Reyes
International Union of Pharmacology. XL. Compendium of voltage-gated ion channels: calcium channels.
Pharmacological reviews 2003;55(4):579-81.
2003: Andreas Brandt; Jörg Striessnig; Tobias Moser
CaV1.3 channels are essential for development and presynaptic activity of cochlear inner hair cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(34):10832-40.
2003: alexandra koschak; Daniel Reimer; Doris Walter; Jean-Charles Hoda; Thomas Heinzle; Manfred Grabner; Jörg Striessnig
Cav1.4alpha1 subunits can form slowly inactivating dihydropyridine-sensitive L-type Ca2+ channels lacking Ca2+-dependent inactivation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(14):6041-9.
2003: Daniela Pietrobon; Jörg Striessnig
Neurobiology of migraine.
Nature reviews. Neuroscience 2003;4(5):386-98.
2003: Matteo E Mangoni; Brigitte Couette; Emmanuel Bourinet; Josef Platzer; Daniel Reimer; Jörg Striessnig; Joël Nargeot
Functional role of L-type Cav1.3 Ca2+ channels in cardiac pacemaker activity.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(9):5543-8.
2003: Rudolf Glueckert; Georg Wietzorrek; Keren Kammen-Jolly; Arne W Scholtz; K Stephan; Jörg Striessnig; Anneliese Schrott-Fischer
Role of class D L-type Ca2+ channels for cochlear morphology.
Hearing research 2003;178(1-2):95-105.
2003: N C Clark; N Nagano; Frederick M Kuenzi; Wolfgang Jarolimek; Irene G Huber; Doris Walter; Georg Wietzorrek; Susan Boyce; D M Kullmann; Jörg Striessnig; Guy R Seabrook
Neurological phenotype and synaptic function in mice lacking the CaV1.3 alpha subunit of neuronal L-type voltage-dependent Ca2+ channels.
Neuroscience 2003;120(2):435-42.
2002: Angelita Tottene; Tommaso Fellin; STEFANO PAGNUTTI; Siro Luvisetto; Jörg Striessnig; Colin Fletcher; Daniela Pietrobon
Familial hemiplegic migraine mutations increase Ca(2+) influx through single human CaV2.1 channels and decrease maximal CaV2.1 current density in neurons.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(20):13284-9.
2002: Monika Hitzl; Jörg Striessnig; Birgit Neuhuber; Bernhard E Flucher
A mutation in the beta interaction domain of the Ca(2+) channel alpha(1C) subunit reduces the affinity of the (+)-[(3)H]isradipine binding site.
FEBS letters 2002;524(1-3):188-92.
2002: Michelle Day; Patricia A Olson; Josef Platzer; Jörg Striessnig; Dalton Surmeier
Stimulation of 5-HT(2) receptors in prefrontal pyramidal neurons inhibits Ca(v)1.2 L type Ca(2+) currents via a PLCbeta/IP3/calcineurin signaling cascade.
Journal of neurophysiology 2002;87(5):2490-504.
2002: Edwin Wappl; alexandra koschak; Michael Poteser; martina Sinnegger-Brauns; Doris Walter; Andreas Eberhart; Klaus Groschner; Hartmut Glossmann; Richard L Kraus; Manfred Grabner; Jörg Striessnig
Functional consequences of P/Q-type Ca2+ channel Cav2.1 missense mutations associated with episodic ataxia type 2 and progressive ataxia.
The Journal of biological chemistry 2002;277(9):6960-6.
2002: Jutta Engel; Marcus Michna; Josef Platzer; Jörg Striessnig
Calcium channels in mouse hair cells: function, properties and pharmacology.
Advances in oto-rhino-laryngology 2002;59():35-41.
2001: alexandra koschak; Daniel Reimer; Irene G Huber; Manfred Grabner; Hartmut Glossmann; J Engel; Jörg Striessnig
alpha 1D (Cav1.3) subunits can form l-type Ca2+ channels activating at negative voltages.
The Journal of biological chemistry 2001;276(25):22100-6.
2001: Edwin Wappl; J Mitterdorfer; Hartmut Glossmann; Jörg Striessnig
Mechanism of dihydropyridine interaction with critical binding residues of L-type Ca2+ channel alpha 1 subunits.
The Journal of biological chemistry 2001;276(16):12730-5.
2000: Claudia Seisenberger; Verena Specht; Andrea Welling; Josef Platzer; Alexander Pfeifer; Susanne Kühbandner; Jörg Striessnig; Norbert Klugbauer; Robert Feil; Franz Hofmann
Functional embryonic cardiomyocytes after disruption of the L-type alpha1C (Cav1.2) calcium channel gene in the mouse.
The Journal of biological chemistry 2000;275(50):39193-9.
2000: Josef Platzer; Jutta Engel; Anneliese Schrott-Fischer; K Stephan; S Bova; H Chen; H Zheng; Jörg Striessnig
Congenital deafness and sinoatrial node dysfunction in mice lacking class D L-type Ca2+ channels.
Cell 2000;102(1):89-97.
2000: Jan Matthes; Irene G Huber; O Haaf; Wolfram Antepohl; Jörg Striessnig; Stefan Herzig
Pharmacodynamic interaction between mibefradil and other calcium channel blockers.
Naunyn-Schmiedeberg's archives of pharmacology 2000;361(6):578-83.
2000: P Eller; S Berjukov; siegmund wanner; Irene G Huber; Steffen Hering; H G Knaus; G Toth; S D Kimball; Jörg Striessnig
High affinity interaction of mibefradil with voltage-gated calcium and sodium channels.
British journal of pharmacology 2000;130(3):669-77.
2000: Irene G Huber; Edwin Wappl; A Herzog; J Mitterdorfer; Hartmut Glossmann; T Langer; Jörg Striessnig
Conserved Ca2+-antagonist-binding properties and putative folding structure of a recombinant high-affinity dihydropyridine-binding domain.
The Biochemical journal 2000;347 Pt 3():829-36.
2000: Richard L Kraus; martina Sinnegger-Brauns; alexandra koschak; Hartmut Glossmann; S Stenirri; P Carrera; Jörg Striessnig
Three new familial hemiplegic migraine mutants affect P/Q-type Ca(2+) channel kinetics.
The Journal of biological chemistry 2000;275(13):9239-43.
2000: Daniel Reimer; Irene G Huber; M L Garcia; H Haase; Jörg Striessnig
beta subunit heterogeneity of L-type Ca(2+) channels in smooth muscle tissues.
FEBS letters 2000;467(1):65-9.
1999: U Gerster; Birgit Neuhuber; Klaus Groschner; Jörg Striessnig; Bernhard E Flucher
Current modulation and membrane targeting of the calcium channel alpha1C subunit are independent functions of the beta subunit.
The Journal of physiology 1999;517 ( Pt 2)():353-68.
1999: B Leitner; Paola Lovisetti-Scamihorn; J Heilmann; Jörg Striessnig; Randy D Blakely; L E Eiden; H Winkler
Subcellular localization of chromogranins, calcium channels, amine carriers, and proteins of the exocytotic machinery in bovine splenic nerve.
Journal of neurochemistry 1999;72(3):1110-6.
1998: Richard L Kraus; Steffen Hering; Manfred Grabner; D Ostler; Jörg Striessnig
Molecular mechanism of diltiazem interaction with L-type Ca2+ channels.
The Journal of biological chemistry 1998;273(42):27205-12.
1998: J Mitterdorfer; Manfred Grabner; Richard L Kraus; Steffen Hering; H Prinz; Hartmut Glossmann; Jörg Striessnig
Molecular basis of drug interaction with L-type Ca2+ channels.
Journal of bioenergetics and biomembranes 1998;30(4):319-34.
1998: Richard L Kraus; martina Sinnegger-Brauns; Hartmut Glossmann; Steffen Hering; Jörg Striessnig
Familial hemiplegic migraine mutations change alpha1A Ca2+ channel kinetics.
The Journal of biological chemistry 1998;273(10):5586-90.
1998: Jörg Striessnig; Manfred Grabner; J Mitterdorfer; Steffen Hering; martina Sinnegger-Brauns; Hartmut Glossmann
Structural basis of drug binding to L Ca2+ channels.
Trends in pharmacological sciences 1998;19(3):108-15.
1997: Steffen Hering; S Aczél; Richard L Kraus; Stanislav Berjukow; Jörg Striessnig; Eugen N Timin
Molecular mechanism of use-dependent calcium channel block by phenylalkylamines: role of inactivation.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(24):13323-8.
1997: martina Sinnegger-Brauns; Z Wang; Manfred Grabner; Steffen Hering; Jörg Striessnig; Hartmut Glossmann; J Mitterdorfer
Nine L-type amino acid residues confer full 1,4-dihydropyridine sensitivity to the neuronal calcium channel alpha1A subunit. Role of L-type Met1188.
The Journal of biological chemistry 1997;272(44):27686-93.
1997: M Pichler; T N Cassidy; Daniel Reimer; H Haase; Richard L Kraus; D Ostler; Jörg Striessnig
Beta subunit heterogeneity in neuronal L-type Ca2+ channels.
The Journal of biological chemistry 1997;272(21):13877-82.
1997: H Safayhi; H Haase; U Kramer; A Bihlmayer; M Roenfeldt; H P T Ammon; M Froschmayr; T N Cassidy; I Morano; M K Ahlijanian; Jörg Striessnig
L-type calcium channels in insulin-secreting cells: biochemical characterization and phosphorylation in RINm5F cells.
Molecular endocrinology (Baltimore, Md.) 1997;11(5):619-29.
1997: Peter Hinterdorfer; Hermann J Gruber; Jörg Striessnig; Hartmut Glossmann; Hansgeorg Schindler
Analysis of membrane protein self-association in lipid systems by fluorescence particle counting: application to the dihydropyridine receptor.
Biochemistry 1997;36(15):4497-504.
1997: T Brauns; H Prinz; S D Kimball; R P Haugland; Jörg Striessnig; Hartmut Glossmann
L-type calcium channels: binding domains for dihydropyridines and benzothiazepines are located in close proximity to each other.
Biochemistry 1997;36(12):3625-31.
1997: Fabian F Moebius; Jörg Striessnig; Hartmut Glossmann
The mysteries of sigma receptors: new family members reveal a role in cholesterol synthesis.
Trends in pharmacological sciences 1997;18(3):67-70.
1996: J Mitterdorfer; Z Wang; martina Sinnegger-Brauns; Steffen Hering; Jörg Striessnig; Manfred Grabner; Hartmut Glossmann
Two amino acid residues in the IIIS5 segment of L-type calcium channels differentially contribute to 1,4-dihydropyridine sensitivity.
The Journal of biological chemistry 1996;271(48):30330-5.
1996: M Pichler; Z Wang; C Grabner-Weiss; D Reimer; Steffen Hering; Manfred Grabner; Hartmut Glossmann; Jörg Striessnig
Block of P/Q-type calcium channels by therapeutic concentrations of aminoglycoside antibiotics.
Biochemistry 1996;35(46):14659-64.
1996: S Berjukov; S Aczel; B Beyer; S D Kimball; M Dichtl; Steffen Hering; Jörg Striessnig
Extra- and intracellular action of quaternary devapamil on muscle L-type Ca(2+)-channels.
British journal of pharmacology 1996;119(6):1197-202.
1996: Steffen Hering; S Aczél; Manfred Grabner; F Döring; Stanislav Berjukow; J Mitterdorfer; martina Sinnegger-Brauns; Jörg Striessnig; Vadim Degtiar; Z Wang; Hartmut Glossmann
Transfer of high sensitivity for benzothiazepines from L-type to class A (BI) calcium channels.
The Journal of biological chemistry 1996;271(40):24471-5.
1996: Richard L Kraus; B Reichl; S D Kimball; Manfred Grabner; B J Murphy; W A Catterall; Jörg Striessnig
Identification of benz(othi)azepine-binding regions within L-type calcium channel alpha1 subunits.
The Journal of biological chemistry 1996;271(33):20113-8.
1996: J Mitterdorfer; M Froschmayr; Manfred Grabner; Fabian F Moebius; Hartmut Glossmann; Jörg Striessnig
Identification of PK-A phosphorylation sites in the carboxyl terminus of L-type calcium channel alpha 1 subunits.
Biochemistry 1996;35(29):9400-6.
1996: Markus Hanner; Fabian F Moebius; A Flandorfer; Hans-Günther Knaus; Jörg Striessnig; E Kempner; Hartmut Glossmann
Purification, molecular cloning, and expression of the mammalian sigma1-binding site.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(15):8072-7.
1996: F Döring; Vadim Degtiar; Manfred Grabner; Jörg Striessnig; Steffen Hering; H Glossman
Transfer of L-type calcium channel IVS6 segment increases phenylalkylamine sensitivity of alpha1A.
The Journal of biological chemistry 1996;271(20):11745-9.
1996: R Boer; M Dichtl; C Borchers; W R Ulrich; J F Marecek; G D Prestwich; Hartmut Glossmann; Jörg Striessnig
Reversible labeling of a chemosensitizer binding domain of p-glycoprotein with a novel 1,4-dihydropyridine drug transport inhibitor.
Biochemistry 1996;35(5):1387-96.
1996: Manfred Grabner; Z Wang; Steffen Hering; Jörg Striessnig; Hartmut Glossmann
Transfer of 1,4-dihydropyridine sensitivity from L-type to class A (BI) calcium channels.
Neuron 1996;16(1):207-18.
1995: Paul Dietl; Thomas Haller; Barbara Wirleitner; Harald Völkl; F Friedrich; Jörg Striessnig
Activation of L-type Ca2+ channels after purinoceptor stimulation by ATP in an alveolar epithelial cell (L2).
The American journal of physiology 1995;269(6 Pt 1):L873-83.
1995: J Mitterdorfer; martina Sinnegger-Brauns; Manfred Grabner; Jörg Striessnig; Hartmut Glossmann
Coordination of Ca2+ by the pore region glutamates is essential for high-affinity dihydropyridine binding to the cardiac Ca2+ channel alpha 1 subunit.
Biochemistry 1995;34(29):9350-5.
1995: Markus Hanner; Fabian F Moebius; F Weber; Manfred Grabner; Jörg Striessnig; Hartmut Glossmann
Phenylalkylamine Ca2+ antagonist binding protein. Molecular cloning, tissue distribution, and heterologous expression.
The Journal of biological chemistry 1995;270(13):7551-7.
1995: T Brauns; Z W Cai; S D Kimball; K C Kang; Richard P Haugland; W Berger; S Berjukov; Steffen Hering; Hartmut Glossmann; Jörg Striessnig
Benzothiazepine binding domain of purified L-type calcium channels: direct labeling using a novel fluorescent diltiazem analogue.
Biochemistry 1995;34(10):3461-9.
1994: Fabian F Moebius; Markus Hanner; Hans-Günther Knaus; F Weber; Jörg Striessnig; Hartmut Glossmann
Purification and amino-terminal sequencing of the high affinity phenylalkylamine Ca2+ antagonist binding protein from guinea pig liver endoplasmic reticulum.
The Journal of biological chemistry 1994;269(46):29314-20.
1994: W Berger; Heino Prinz; Jörg Striessnig; H C Kang; R Haugland; Hartmut Glossmann
Complex molecular mechanism for dihydropyridine binding to L-type Ca(2+)-channels as revealed by fluorescence resonance energy transfer.
Biochemistry 1994;33(39):11875-83.
1994: J Mitterdorfer; M Froschmayr; Manfred Grabner; Jörg Striessnig; Hartmut Glossmann
Calcium channels: the beta-subunit increases the affinity of dihydropyridine and Ca2+ binding sites of the alpha 1-subunit.
FEBS letters 1994;352(2):141-5.
1994: Manfred Grabner; A Bachmann; F Rosenthal; Jörg Striessnig; C Schultz; D Tautz; Hartmut Glossmann
Insect calcium channels. Molecular cloning of an alpha 1-subunit from housefly (Musca domestica) muscle.
FEBS letters 1994;339(1-2):189-94.
1993: Fabian F Moebius; Gregory G Burrows; Markus Hanner; E Schmid; Jörg Striessnig; Hartmut Glossmann
Identification of a 27-kDa high affinity phenylalkylamine-binding polypeptide as the sigma 1 binding site by photoaffinity labeling and ligand-directed antibodies.
Molecular pharmacology 1993;44(5):966-71.
1993: Heino Prinz; Jörg Striessnig
Ligand-induced accelerated dissociation of (+)-cis-diltiazem from L-type Ca2+ channels is simply explained by competition for individual attachment points.
The Journal of biological chemistry 1993;268(25):18580-5.
1993: Steffen Hering; Alex Savchenko; C Strübing; M Lakitsch; Jörg Striessnig
Extracellular localization of the benzothiazepine binding domain of L-type Ca2+ channels.
Molecular pharmacology 1993;43(5):820-6.
1993: Fabian F Moebius; Gregory G Burrows; Jörg Striessnig; Hartmut Glossmann
Biochemical characterization of a 22-kDa high affinity antiischemic drug-binding polypeptide in the endoplasmic reticulum of guinea pig liver: potential common target for antiischemic drug action.
Molecular pharmacology 1993;43(2):139-48.
1993: M Lakitsch; Hans-Günther Knaus; Gerda Topar; Christoph Romanin; R Boer; D Flockerzi; Jörg Striessnig; Hansgeorg Schindler; H D Hoeltje; Hartmut Glossmann
Heterogeneity of L-type calcium channel alpha 1 subunits: stereoselective discrimination of different populations by the novel 1,4-dihydropyridine B 874-67.
Molecular pharmacology 1993;43(2):293-301.
1992: Hans-Günther Knaus; Jörg Striessnig; S Hering; S Marrer; E Schwenner; Hans-Dieter Höltje; Hartmut Glossmann
[35S]sadopine, a novel high affinity, high specific activity, L-type Ca2+ channel probe: characterization of two equipotent diastereomers with opposite allosteric properties.
Molecular pharmacology 1992;41(2):298-307.
1991: Hartmut Glossmann; C Zech; Jörg Striessnig; R Staudinger; L Hall; R Greenberg; B I Armah
Very high affinity interaction of DPI 201-106 and BDF 8784 enantiomers with the phenylalkylamine-sensitive Ca2(+)-channel in Drosophila head membranes.
British journal of pharmacology 1991;102(2):446-52.
1991: Manfred Grabner; K Friedrich; Hans-Günther Knaus; Jörg Striessnig; F Scheffauer; R Staudinger; Walter J Koch; A Schwartz; Hartmut Glossmann
Calcium channels from Cyprinus carpio skeletal muscle.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(3):727-31.
1990: Jörg Striessnig; F Scheffauer; J Mitterdorfer; Michael Schirmer; Hartmut Glossmann
Identification of the benzothiazepine-binding polypeptide of skeletal muscle calcium channels with (+)-cis-azidodiltiazem and anti-ligand antibodies.
The Journal of biological chemistry 1990;265(1):363-70.
1990: Hartmut Glossmann; Jörg Striessnig
Molecular properties of calcium channels.
Reviews of physiology, biochemistry and pharmacology 1990;114():1-105.
1989: A Grassegger; Jörg Striessnig; M Weiler; Hans-Günther Knaus; Hartmut Glossmann
[3H]HOE166 defines a novel calcium antagonist drug receptor--distinct from the 1,4 dihydropyridine binding domain.
Naunyn-Schmiedeberg's archives of pharmacology 1989;340(6 Pt 2):752-9.
1989: Hartmut Glossmann; Jörg Striessnig; Hans-Günther Knaus; J Müller; A Grassegger; Hans-Dieter Höltje; S Marrer; L Hymel; Hansgeorg Schindler
Structure of calcium channels.
Annals of the New York Academy of Sciences 1989;560():198-214.
1988: Jörg Striessnig; Hans-Günther Knaus; Hartmut Glossmann
Photoaffinity-labelling of the calcium-channel-associated 1,4-dihydropyridine and phenylalkylamine receptor in guinea-pig hippocampus. A 195 kDa polypeptide carries both drug receptors and has similarities to the alpha 1 subunit of the purified skeletal-muscle calcium channel.
The Biochemical journal 1988;253(1):39-47.
1988: L Hymel; Jörg Striessnig; Hartmut Glossmann; Hansgeorg Schindler
Purified skeletal muscle 1,4-dihydropyridine receptor forms phosphorylation-dependent oligomeric calcium channels in planar bilayers.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(12):4290-4.
1988: Jörg Striessnig; E Meusburger; Manfred Grabner; Hans-Günther Knaus; Hartmut Glossmann; J Kaiser; B Schölkens; R Becker; W Linz; R Henning
Evidence for a distinct Ca2+ antagonist receptor for the novel benzothiazinone compound HOE 166.
Naunyn-Schmiedeberg's archives of pharmacology 1988;337(3):331-40.
1988: Hartmut Glossmann; Jörg Striessnig; L Hymel; Hansgeorg Schindler
Purification and reconstitution of calcium channel drug-receptor sites.
Annals of the New York Academy of Sciences 1988;522():150-61.
1988: Jörg Striessnig; Hartmut Glossmann
Characterization of the drug receptors of the purified skeletal muscle calcium channel.
Progress in clinical and biological research 1988;252():35-40.
1987: Hans-Günther Knaus; Jörg Striessnig; A Koza; Hartmut Glossmann
Neurotoxic aminoglycoside antibiotics are potent inhibitors of [125I]-Omega-Conotoxin GVIA binding to guinea-pig cerebral cortex membranes.
Naunyn-Schmiedeberg's archives of pharmacology 1987;336(5):583-6.
1987: Hartmut Glossmann; Jörg Striessnig; D R Ferry; A Goll; K Moosburger; Michael Schirmer
Interaction between calcium channel ligands and calcium channels.
Circulation research 1987;61(4 Pt 2):I30-6.
1987: Jörg Striessnig; Hans-Günther Knaus; Manfred Grabner; K Moosburger; W Seitz; H Lietz; Hartmut Glossmann
Photoaffinity labelling of the phenylalkylamine receptor of the skeletal muscle transverse-tubule calcium channel.
FEBS letters 1987;212(2):247-53.
1987: Hartmut Glossmann; Jörg Striessnig; L Hymel; Hansgeorg Schindler
Purified L-type calcium channels: only one single polypeptide (alpha 1-subunit) carries the drug receptor domains and is regulated by protein kinases.
Biomedica biochimica acta 1987;46(8-9):S351-6.
1986: Jörg Striessnig; K Moosburger; A Goll; D R Ferry; Hartmut Glossmann
Stereoselective photoaffinity labelling of the purified 1,4-dihydropyridine receptor of the voltage-dependent calcium channel.
European journal of biochemistry / FEBS 1986;161(3):603-9.
1986: Jörg Striessnig; A Goll; K Moosburger; Hartmut Glossmann
Purified calcium channels have three allosterically coupled drug receptors.
FEBS letters 1986;197(1-2):204-10.
1985: Jörg Striessnig; G Zernig; Hartmut Glossmann
Human red-blood-cell Ca2+-antagonist binding sites. Evidence for an unusual receptor coupled to the nucleoside transporter.
European journal of biochemistry / FEBS 1985;150(1):67-77.
1985: Jörg Striessnig; G Zernig; Hartmut Glossmann
Ca2+ antagonist receptor sites on human red blood cell membranes.
European journal of pharmacology 1985;108(3):329-30.
1985: Hartmut Glossmann; D R Ferry; A Goll; Jörg Striessnig; G Zernig
Calcium channels and calcium channel drugs: recent biochemical and biophysical findings.
Arzneimittel-Forschung 1985;35(12A):1917-35.
1985: Hartmut Glossmann; D R Ferry; A Goll; Jörg Striessnig; M Schober
Calcium channels: basic properties as revealed by radioligand binding studies.
Journal of cardiovascular pharmacology 1985;7 Suppl 6():S20-30.
1984: A Goll; D R Ferry; Jörg Striessnig; M Schober; Hartmut Glossmann
(-)-[3H]Desmethoxyverapamil, a novel Ca2+ channel probe. Binding characteristics and target size analysis of its receptor in skeletal muscle.
FEBS letters 1984;176(2):371-7.