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Judy Bolton

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TOP 3
Atieh Hajirahimkhan; Birgit M Dietz; Judy L Bolton
Botanical modulation of menopausal symptoms: mechanisms of action?
Bradley T Michalsen; Zhihui Qin; Gregory R J Thatcher; Ranepuradewage Chandrasena; Jaewoo Choi; Teshome B Gherezghiher; Judy L Bolton
Selective estrogen receptor modulator (SERM) lasofoxifene forms reactive quinones similar to estradiol.
M F Toh; Ping Yao; Judy L Bolton; Shaonong Chen; J Sohn; Joanna E Burdette
Biological characterization of non-steroidal progestins from botanicals used for women's health.

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All Publications

2013: Atieh Hajirahimkhan; Birgit M Dietz; Judy L Bolton
Botanical modulation of menopausal symptoms: mechanisms of action?
Planta medica 2013;79(7):538-53.
2012: Bradley T Michalsen; Zhihui Qin; Gregory R J Thatcher; Ranepuradewage Chandrasena; Jaewoo Choi; Teshome B Gherezghiher; Judy L Bolton
Selective estrogen receptor modulator (SERM) lasofoxifene forms reactive quinones similar to estradiol.
Chemical research in toxicology 2012;25(7):1472-83.
2012: M F Toh; Ping Yao; Judy L Bolton; Shaonong Chen; J Sohn; Joanna E Burdette
Biological characterization of non-steroidal progestins from botanicals used for women's health.
Steroids 2012;77(7):765-73.
2012: Teshome B Gherezghiher; Bradley Michalsen; Zhihui Qin; Johann Sohn; Gregory R J Thatcher; Ranepuradewage Chandrasena; Judy L Bolton
The naphthol selective estrogen receptor modulator (SERM), LY2066948, is oxidized to an o-quinone analogous to the naphthol equine estrogen, equilenin.
Chemico-biological interactions 2012;196(1-2):1-10.
2012: L P Hemachandra; Guido F Pauli; Matthew Main; Birgit M Dietz; Ranepuradewage Chandrasena; David C Lankin; Gregory R J Thatcher; Robert A Scism; Shao-Nong Chen; P Madhubhani; P Esala; Judy L Bolton
Hops (Humulus lupulus) inhibits oxidative estrogen metabolism and estrogen-induced malignant transformation in human mammary epithelial cells (MCF-10A).
Cancer prevention research (Philadelphia, Pa.) 2012;5(1):73-81.
2012: Tanja Goedecke; José G Napolitano; Ping Yao; Birgit M Dietz; David C Lankin; Dejan Nikolić; Richard B Van Breemen; Norman R Farnsworth; Judy L Bolton; Shao-Nong Chen; Guido F Pauli
Integrated standardization concept for Angelica botanicals using quantitative NMR.
Fitoterapia 2012;83(1):18-32.
2011: Carol A Shultz; Ronald G Harvey; Edmund Maser; Jong-Heum Park; Amy M Quinn; Judy L Bolton; Trevor M Penning
Specificity of human aldo-keto reductases, NAD(P)H:quinone oxidoreductase, and carbonyl reductases to redox-cycle polycyclic aromatic hydrocarbon diones and 4-hydroxyequilenin-o-quinone.
Chemical research in toxicology 2011;24(12):2153-66.
2011: Yang Liu; Dara Reeves; Bennett Van Houten; Alexander Kolbanovskiy; Marina Kolbanovskiy; Konstantin Kropachev; Judy L Bolton; Suse Broyde; Yuqin Cai; Shuang Ding; Nicholas E Geacintov
Probing for DNA damage with β-hairpins: similarities in incision efficiencies of bulky DNA adducts by prokaryotic and human nucleotide excision repair systems in vitro.
DNA repair 2011;10(7):684-96.
2011: Birgit M Dietz; Judy L Bolton
Biological reactive intermediates (BRIs) formed from botanical dietary supplements.
Chemico-biological interactions 2011;192(1-2):72-80.
2011: Irida Kastrati; Yue-Ting Wang; Judy L Bolton; Ranepuradewage Chandrasena; Jaewoo Choi; Praneeth D Edirisinghe; L-P-Madhubani P Hemachandra; Gregory R J Thatcher
Raloxifene and desmethylarzoxifene block estrogen-induced malignant transformation of human breast epithelial cells.
PloS one 2011;6(11):e27876.
2010: Kuan-Wei Peng; Minsun Chang; Yueting Wang; Zhican Wang; Zhihui Qin; Judy L Bolton; Gregory R J Thatcher
Unexpected hormonal activity of a catechol equine estrogen metabolite reveals reversible glutathione conjugation.
Chemical research in toxicology 2010;23(8):1374-83.
2010: Zhican Wang; Ranepuradewage Chandrasena; Yang Yuan; Kuan-Wei Peng; Richard B Van Breemen; Gregory R J Thatcher; Judy L Bolton
Redox cycling of catechol estrogens generating apurinic/apyrimidinic sites and 8-oxo-deoxyguanosine via reactive oxygen species differentiates equine and human estrogens.
Chemical research in toxicology 2010;23(8):1365-73.
2010: Richard B Van Breemen; W Liang; Suzanne Banuvar; Lee P Shulman; Y Pang; Y Tao; Dejan Nikolic; K M Krock; Daniel S Fabricant; Shaonong Chen; Samad Hedayat; Judy L Bolton; Guido F Pauli; Colleen E Piersen; E C Krause; Stacie E Geller; Norman R Farnsworth
Pharmacokinetics of 23-epi-26-deoxyactein in women after oral administration of a standardized extract of black cohosh.
Clinical pharmacology and therapeutics 2010;87(2):219-25.
2010: Matthias Barton; Matthias R Meyer; Judy L Bolton; Eric R Prossnitz
Lung cancer and hormone replacement therapy.
Lancet 2010;375(9709):117-8; author reply 118-9.
2009: Kuan-Wei Peng; Huali Wang; Zhihui Qin; Gihani Wijewickrama; Meiling Lu; Zhican Wang; Judy L Bolton; Gregory R J Thatcher
Selective estrogen receptor modulator delivery of quinone warheads to DNA triggering apoptosis in breast cancer cells.
ACS chemical biology 2009;4(12):1039-49.
2009: Stacie E Geller; Lee P Shulman; Richard B Van Breemen; Suzanne Banuvar; Ying Zhou; Geena Epstein; Samad Hedayat; Dejan Nikolic; Elizabeth C Krause; Colleen E Piersen; Judy L Bolton; Guido F Pauli; Norman R Farnsworth
Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms: a randomized controlled trial.
Menopause (New York, N.Y.) 2009;16(6):1156-66.
2009: Na Zhang; Shuang Ding; Alexander Kolbanovskiy; Anant Shastry; Vladimir A Kuzmin; Judy L Bolton; Dinshaw J Patel; Suse Broyde; Nicholas E Geacintov
NMR and computational studies of stereoisomeric equine estrogen-derived DNA cytidine adducts in oligonucleotide duplexes: opposite orientations of diastereomeric forms.
Biochemistry 2009;48(30):7098-109.
2009: Zhican Wang; Praneeth D Edirisinghe; Johann Sohn; Zhihui Qin; Nicholas E Geacintov; Gregory R J Thatcher; Judy L Bolton
Development of a liquid chromatography electrospray ionization tandem mass spectrometry method for analysis of stable 4-hydroxyequilenin-DNA adducts in human breast cancer cells.
Chemical research in toxicology 2009;22(6):1129-36.
2009: Bolan Yu; Zhihui Qin; Gihani Wijewickrama; Praneeth Edirisinghe; Judy L Bolton; Gregory R J Thatcher
Comparative methods for analysis of protein covalent modification by electrophilic quinoids formed from xenobiotics.
Bioconjugate chemistry 2009;20(4):728-41.
2009: Zhican Wang; Gihani Wijewickrama; Kuan-Wei Peng; Birgit M Dietz; Long Yuan; Richard B Van Breemen; Judy L Bolton; Gregory R J Thatcher
Estrogen Receptor {alpha} Enhances the Rate of Oxidative DNA Damage by Targeting an Equine Estrogen Catechol Metabolite to the Nucleus.
The Journal of biological chemistry 2009;284(13):8633-42.
2009: Tanja Gödecke; Dejan Nikolic; David C Lankin; Shaonong Chen; Sharla L Powell; Birgit M Dietz; Judy L Bolton; Richard B Van Breemen; Norman R Farnsworth; Guido F Pauli
Phytochemistry of cimicifugic acids and associated bases in Cimicifuga racemosa root extracts.
Phytochemical analysis : PCA 2009;20(2):120-33.
2009: Zhihui Qin; Irida Kastrati; Rezene T Ashgodom; Daniel D Lantvit; Cassia R Overk; Yongsoo Choi; Richard B Van Breemen; Judy L Bolton; Gregory R J Thatcher
Structural modulation of oxidative metabolism in design of improved benzothiophene selective estrogen receptor modulators.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(1):161-9.
2008: Sharla L Powell; Tanja Gödecke; Dejan Nikolic; Shaonong Chen; Soyoun Ahn; Birgit M Dietz; Norman R Farnsworth; Richard B Van Breemen; David C Lankin; Guido F Pauli; Judy L Bolton
In vitro serotonergic activity of black cohosh and identification of N(omega)-methylserotonin as a potential active constituent.
Journal of agricultural and food chemistry 2008;56(24):11718-26.
2008: Cassia R Overk; Jian Guo; Lucas R Chadwick; Daniel D Lantvit; Alberto Minassi; Giovanni Appendino; Shaonong Chen; David C Lankin; Norman R Farnsworth; Guido F Pauli; Richard B Van Breemen; Judy L Bolton
In vivo estrogenic comparisons of Trifolium pratense (red clover) Humulus lupulus (hops), and the pure compounds isoxanthohumol and 8-prenylnaringenin.
Chemico-biological interactions 2008;176(1):30-9.
2008: Birgit M Dietz; Dongting Liu; Ghenet Hagos; Ping Yao; Andreas Schinkovitz; Samuel M Pro; Shixin Deng; Norman R Farnsworth; Guido F Pauli; Richard B Van Breemen; Judy L Bolton
Angelica sinensis and its alkylphthalides induce the detoxification enzyme NAD(P)H: quinone oxidoreductase 1 by alkylating Keap1.
Chemical research in toxicology 2008;21(10):1939-48.
2008: Shuang Ding; Yan Wang; Alexander Kolbanovskiy; Alexander Durandin; Judy L Bolton; Richard B Van Breemen; Suse Broyde; Nicholas E Geacintov
Determination of absolute configurations of 4-hydroxyequilenin-cytosine and -adenine adducts by optical rotatory dispersion, electronic circular dichroism, density functional theory calculations, and mass spectrometry.
Chemical research in toxicology 2008;21(9):1739-48.
2008: Ranepuradewage Chandrasena; Praneeth D Edirisinghe; Judy L Bolton; Gregory R J Thatcher
Problematic detoxification of estrogen quinones by NAD(P)H-dependent quinone oxidoreductase and glutathione-S-transferase.
Chemical research in toxicology 2008;21(7):1324-9.
2008: Cassia R Overk; Ping Yao; Shaonong Chen; Shixing Deng; Ayano Imai; Matthew Main; Andreas Schinkovitz; Norman R Farnsworth; Guido F Pauli; Judy L Bolton
High-content screening and mechanism-based evaluation of estrogenic botanical extracts.
Combinatorial chemistry & high throughput screening 2008;11(4):283-93.
2008: Norman R Farnsworth; Elizabeth C Krause; Judy L Bolton; Guido F Pauli; Richard B Van Breemen; James G Graham
The University of Illinois at Chicago/National Institutes of Health Center for Botanical Dietary Supplements Research for Women's Health: from plant to clinical use.
The American journal of clinical nutrition 2008;87(2):504S-8S.
2008: Minsun Chang; Cassia R Overk; Irida Kastrati; Kuan-Wei Peng; Ping Yao; Zhihui Qin; Pavel A Petukhov; Judy L Bolton; Gregory R J Thatcher
Estrogenic activity of the equine estrogen metabolite, 4-methoxyequilenin.
Advances in experimental medicine and biology 2008;617():601-7.
2008: Judy L Bolton; Gregory R J Thatcher
Potential mechanisms of estrogen quinone carcinogenesis.
Chemical research in toxicology 2008;21(1):93-101.
2007: Hong Liu; Zhihui Qin; Gregory R J Thatcher; Judy L Bolton
Uterine peroxidase-catalyzed formation of diquinone methides from the selective estrogen receptor modulators raloxifene and desmethylated arzoxifene.
Chemical research in toxicology 2007;20(11):1676-84.
2007: Joanna Lynn Michel; Reinel Eduardo Duarte; Judy L Bolton; Yue Huang; Armando Caceres; Mario Veliz; D Doel Soejarto; Gail B Mahady
Medical potential of plants used by the Q'eqchi Maya of Livingston, Guatemala for the treatment of women's health complaints.
Journal of ethnopharmacology 2007;114(1):92-101.
2007: Cassia R Overk; Kuan-Wei Peng; Rezene T Asghodom; Irida Kastrati; Daniel D Lantvit; Zhihui Qin; Jonna Frasor; Judy L Bolton; Gregory R J Thatcher
Structure-activity relationships for a family of benzothiophene selective estrogen receptor modulators including raloxifene and arzoxifene.
ChemMedChem 2007;2(10):1520-6.
2007: Minsun Chang; Kuan-Wei Peng; Irida Kastrati; Cassia R Overk; Zhihui Qin; Ping Yao; Judy L Bolton; Gregory R J Thatcher
Activation of estrogen receptor-mediated gene transcription by the equine estrogen metabolite, 4-methoxyequilenin, in human breast cancer cells.
Endocrinology 2007;148(10):4793-802.
2007: Bolan Yu; Birgit M Dietz; Tareisha Dunlap; Irida Kastrati; Daniel D Lantvit; Cassia R Overk; Ping Yao; Zhihui Qin; Judy L Bolton; Gregory R J Thatcher
Structural modulation of reactivity/activity in design of improved benzothiophene selective estrogen receptor modulators: induction of chemopreventive mechanisms.
Molecular cancer therapeutics 2007;6(9):2418-28.
2007: Zhihui Qin; Irida Kastrati; Ranepuradewage Chandrasena; Hong Liu; Ping Yao; Pavel A Petukhov; Judy L Bolton; Gregory R J Thatcher
Benzothiophene selective estrogen receptor modulators with modulated oxidative activity and receptor affinity.
Journal of medicinal chemistry 2007;50(11):2682-92.
2007: Birgit M Dietz; Judy L Bolton
Botanical dietary supplements gone bad.
Chemical research in toxicology 2007;20(4):586-90.
2006: Tamara S Dowers; Zhihui Qin; Gregory R J Thatcher; Judy L Bolton
Bioactivation of Selective Estrogen Receptor Modulators (SERMs).
Chemical research in toxicology 2006;19(9):1125-37.
2006: Muriel Cuendet; Judy L Bolton
Response of human mammary epithelial cells to DNA damage induced by 4-hydroxyequilenin: Lack of p53-mediated G1 arrest.
Chemico-biological interactions 2006;161(3):271-8.
2006: Hong Liu; Judy L Bolton; Gregory R J Thatcher
Chemical modification modulates estrogenic activity, oxidative reactivity, and metabolic stability in 4'F-DMA, a new benzothiophene selective estrogen receptor modulator.
Chemical research in toxicology 2006;19(6):779-87.
2006: Shixin Deng; Shaonong Chen; Ping Yao; Dejan Nikolic; Richard B Van Breemen; Judy L Bolton; Harry H S Fong; Norman R Farnsworth; Guido F Pauli
Serotonergic activity-guided phytochemical investigation of the roots of Angelica sinensis.
Journal of natural products 2006;69(4):536-41.
2006: Nancy Booth; Cassia R Overk; Ping Yao; Joanna E Burdette; Dejan Nikolic; Shaonong Chen; Judy L Bolton; Richard B Van Breemen; Guido F Pauli; Norman R Farnsworth
The chemical and biologic profile of a red clover (Trifolium pratense L.) phase II clinical extract.
Journal of alternative and complementary medicine (New York, N.Y.) 2006;12(2):133-9.
2006: Stefan Gafner; Birgit M Dietz; Kerry L McPhail; Ian M Scott; Jan A Glinski; Fiona E Russell; Megan M McCollom; Jason W Budzinski; Brian C Foster; Chantal Bergeron; Mee-Ra Rhyu; Judy L Bolton
Alkaloids from Eschscholzia californica and their capacity to inhibit binding of [3H]8-Hydroxy-2-(di-N-propylamino)tetralin to 5-HT1A receptors in Vitro.
Journal of natural products 2006;69(3):432-5.
2006: Nancy Booth; Cassia R Overk; Ping Yao; Steven Totura; Yunfan Deng; Samad Hedayat; Judy L Bolton; Guido F Pauli; Norman R Farnsworth
Seasonal variation of red clover (Trifolium pratense L., Fabaceae) isoflavones and estrogenic activity.
Journal of agricultural and food chemistry 2006;54(4):1277-82.
2005: Yan Li; Xiaofeng Yang; Richard B Van Breemen; Judy L Bolton
Characterization of two new variants of human catechol O-methyltransferase in vitro.
Cancer letters 2005;230(1):81-9.
2005: Alexander Kolbanovskiy; Vladimir Kuzmin; Anant Shastry; Marina Kolbanovskaya; Dandan Chen; Minsun Chang; Judy L Bolton; Nicholas E Geacintov
Base selectivity and effects of sequence and DNA secondary structure on the formation of covalent adducts derived from the equine estrogen metabolite 4-hydroxyequilenin.
Chemical research in toxicology 2005;18(11):1737-47.
2005: Guowen Liu; Aimee L Eggler; Birgit M Dietz; Andrew D Mesecar; Judy L Bolton; John M Pezzuto; Richard B Van Breemen
Screening method for the discovery of potential cancer chemoprevention agents based on mass spectrometric detection of alkylated Keap1.
Analytical chemistry 2005;77(19):6407-14.
2005: Jianhua Liu; Qian Li; Xiaofeng Yang; Richard B Van Breemen; Judy L Bolton; Gregory R J Thatcher
Analysis of protein covalent modification by xenobiotics using a covert oxidatively activated tag: raloxifene proof-of-principle study.
Chemical research in toxicology 2005;18(9):1485-96.
2005: Cassia R Overk; Ping Yao; Lucas R Chadwick; Dejan Nikolic; Yongkai Sun; Muriel Cuendet; Yunfan Deng; Samad Hedayat; Guido F Pauli; Norman R Farnsworth; Richard B Van Breemen; Judy L Bolton
Comparison of the in vitro estrogenic activities of compounds from hops (Humulus lupulus) and red clover (Trifolium pratense).
Journal of agricultural and food chemistry 2005;53(16):6246-53.
2005: Birgit M Dietz; Young-Hwa Kang; Guowen Liu; Aimee L Eggler; Ping Yao; Lucas R Chadwick; Guido F Pauli; Norman R Farnsworth; Andrew D Mesecar; Richard B Van Breemen; Judy L Bolton
Xanthohumol isolated from Humulus lupulus Inhibits menadione-induced DNA damage through induction of quinone reductase.
Chemical research in toxicology 2005;18(8):1296-305.
2005: Yan Li; Xiaofeng Yang; Minsun Chang; James D Yager; Richard B Van Breemen; Judy L Bolton
Functional and structural comparisons of cysteine residues in the Val108 wild type and Met108 variant of human soluble catechol O-methyltransferase.
Chemico-biological interactions 2005;152(2-3):151-63.
2005: Jianhua Liu; Hong Liu; Richard B Van Breemen; Gregory R J Thatcher; Judy L Bolton
Bioactivation of the selective estrogen receptor modulator acolbifene to quinone methides.
Chemical research in toxicology 2005;18(2):174-82.
2005: Hong Liu; Jianhua Liu; Richard B Van Breemen; Gregory R J Thatcher; Judy L Bolton
Bioactivation of the selective estrogen receptor modulator desmethylated arzoxifene to quinoids: 4'-fluoro substitution prevents quinoid formation.
Chemical research in toxicology 2005;18(2):162-73.
2005: Yongkai Sun; Chungang Gu; Xuemei Liu; Wenzhong Liang; Ping Yao; Judy L Bolton; Richard B Van Breemen
Ultrafiltration tandem mass spectrometry of estrogens for characterization of structure and affinity for human estrogen receptors.
Journal of the American Society for Mass Spectrometry 2005;16(2):271-9.
2004: Yan Li; Jiaqin Yao; Minsun Chang; Muriel Cuendet; Judy L Bolton
Altered apoptotic response in MCF 10A cells treated with the equine estrogen metabolite, 4-hydroxyequilenin.
Toxicology letters 2004;154(3):225-33.
2004: Lucas R Chadwick; Dejan Nikolic; Joanna E Burdette; Cassia R Overk; Judy L Bolton; Richard B Van Breemen; Roland Fröhlich; Harry H S Fong; Norman R Farnsworth; Guido F Pauli
Estrogens and congeners from spent hops (Humulus lupulus).
Journal of natural products 2004;67(12):2024-32.
2004: Linning Yu; Hong Liu; Wenkui Li; Fagen Zhang; Connie Luckie; Richard B Van Breemen; Gregory R J Thatcher; Judy L Bolton
Oxidation of raloxifene to quinoids: potential toxic pathways via a diquinone methide and o-quinones.
Chemical research in toxicology 2004;17(7):879-88.
2004: Muriel Cuendet; Xuemei Liu; Emily Pisha; Yan Li; Jiaqin Yao; Linning Yu; Judy L Bolton
Equine estrogen metabolite 4-hydroxyequilenin induces anchorage-independent growth of human mammary epithelial MCF-10A cells: differential gene expression.
Mutation research 2004;550(1-2):109-21.
2004: Colleen E Piersen; Nancy Booth; Yongkai Sun; W Liang; Joanna E Burdette; Richard B Van Breemen; Stacie E Geller; C Gu; Suzanne Banuvar; Lee P Shulman; Judy L Bolton; Norman R Farnsworth
Chemical and biological characterization and clinical evaluation of botanical dietary supplements: a phase I red clover extract as a model.
Current medicinal chemistry 2004;11(11):1361-74.
2004: Yan Li; Jiaqin Yao; Minsun Chang; Dejan Nikolic; Linning Yu; James D Yager; Andrew D Mesecar; Richard B Van Breemen; Judy L Bolton
Equine catechol estrogen 4-hydroxyequilenin is a more potent inhibitor of the variant form of catechol-O-methyltransferase.
Chemical research in toxicology 2004;17(4):512-20.
2004: Judy L Bolton; Linning Yu; Gregory R J Thatcher
Quinoids formed from estrogens and antiestrogens.
Methods in enzymology 2004;378():110-23.
2004: Jianhua Liu; Joanna E Burdette; Yongkai Sun; S Deng; S M Schlecht; W Zheng; Dejan Nikolic; Gail B Mahady; Richard B Van Breemen; Harry H S Fong; John M Pezzuto; Judy L Bolton; Norman R Farnsworth
Isolation of linoleic acid as an estrogenic compound from the fruits of Vitex agnus-castus L. (chaste-berry).
Phytomedicine : international journal of phytotherapy and phytopharmacology 2004;11(1):18-23.
2003: Violeta Toader; Xudong Xu; Adrian Nicolescu; Linning Yu; Judy L Bolton; Gregory R J Thatcher
Nitrosation, nitration, and autoxidation of the selective estrogen receptor modulator raloxifene by nitric oxide, peroxynitrite, and reactive nitrogen/oxygen species.
Chemical research in toxicology 2003;16(10):1264-76.
2003: Joanna E Burdette; Jianhua Liu; Shaonong Chen; Daniel S Fabricant; Colleen E Piersen; Eric L Barker; John M Pezzuto; Andrew D Mesecar; Richard B Van Breemen; Norman R Farnsworth; Judy L Bolton
Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor.
Journal of agricultural and food chemistry 2003;51(19):5661-70.
2003: Xuemei Liu; Emily Pisha; Debra A Tonetti; Dan Yao; Yan Li; Jiaqin Yao; Joanna E Burdette; Judy L Bolton
Antiestrogenic and DNA damaging effects induced by tamoxifen and toremifene metabolites.
Chemical research in toxicology 2003;16(7):832-7.
2003: Xuemei Liu; Fagen Zhang; Hong Liu; Joanna E Burdette; Yan Li; Cassia R Overk; Emily Pisha; Jiaqin Yao; Richard B Van Breemen; Steven M Swanson; Judy L Bolton
Effect of halogenated substituents on the metabolism and estrogenic effects of the equine estrogen, equilenin.
Chemical research in toxicology 2003;16(6):741-9.
2003: Benjamin M Johnson; Samuel X Qiu; Shide Zhang; Fagen Zhang; Joanna E Burdette; Linning Yu; Judy L Bolton; Richard B Van Breemen
Identification of novel electrophilic metabolites of piper methysticum Forst (Kava).
Chemical research in toxicology 2003;16(6):733-40.
2003: Jiaqin Yao; Yan Li; Minsun Chang; Huaping Wu; Xiaofeng Yang; Julie E Goodman; Xuemei Liu; Hong Liu; Andrew D Mesecar; Richard B Van Breemen; James D Yager; Judy L Bolton
Catechol estrogen 4-hydroxyequilenin is a substrate and an inhibitor of catechol-O-methyltransferase.
Chemical research in toxicology 2003;16(5):668-75.
2002: Haiyan Xu; Daniel S Fabricant; Colleen E Piersen; Judy L Bolton; John M Pezzuto; Harry H S Fong; Steven Totura; Norman R Farnsworth; Andreas I Constantinou
A preliminary RAPD-PCR analysis of Cimicifuga species and other botanicals used for women's health.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2002;9(8):757-62.
2002: Joanna E Burdette; Shaonong Chen; Zhi-Zhen Lu; Haiyan Xu; Bethany E P White; Daniel S Fabricant; Jianhua Liu; Harry H S Fong; Norman R Farnsworth; Andreas I Constantinou; Richard B Van Breemen; John M Pezzuto; Judy L Bolton
Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: bioassay-directed isolation and characterization of active principles.
Journal of agricultural and food chemistry 2002;50(24):7022-8.
2002: Judy L Bolton
Quinoids, quinoid radicals, and phenoxyl radicals formed from estrogens and antiestrogens.
Toxicology 2002;177(1):55-65.
2002: Jiaqin Yao; Minsun Chang; Yan Li; Emily Pisha; Xuemei Liu; Dan Yao; Ebrahim Elguindi; Sylvie Blond; Judy L Bolton
Inhibition of cellular enzymes by equine catechol estrogens in human breast cancer cells: specificity for glutathione S-transferase P1-1.
Chemical research in toxicology 2002;15(7):935-42.
2002: Xuemei Liu; Jiaqin Yao; Emily Pisha; Yanan Yang; Yousheng Hua; Richard B Van Breemen; Judy L Bolton
Oxidative DNA damage induced by equine estrogen metabolites: role of estrogen receptor alpha.
Chemical research in toxicology 2002;15(4):512-9.
2002: Young Geun Shin; Judy L Bolton; Richard B Van Breemen
Screening drugs for metabolic stability using pulsed ultrafiltration mass spectrometry.
Combinatorial chemistry & high throughput screening 2002;5(1):59-64.
2002: Joanna E Burdette; Jianhua Liu; Daniel D Lantvit; Eula Lim; Nancy Booth; Krishna P L Bhat; Samad Hedayat; Richard B Van Breemen; Andreas I Constantinou; John M Pezzuto; Norman R Farnsworth; Judy L Bolton
Trifolium pratense (red clover) exhibits estrogenic effects in vivo in ovariectomized Sprague-Dawley rats.
The Journal of nutrition 2002;132(1):27-30.
2001: Fagen Zhang; Steven M Swanson; Richard B Van Breemen; Xuemei Liu; Yanan Yang; C Gu; Judy L Bolton
Equine estrogen metabolite 4-hydroxyequilenin induces DNA damage in the rat mammary tissues: formation of single-strand breaks, apurinic sites, stable adducts, and oxidized bases.
Chemical research in toxicology 2001;14(12):1654-9.
2001: Dan Yao; Fagen Zhang; Linning Yu; Yanan Yang; Richard B Van Breemen; Judy L Bolton
Synthesis and reactivity of potential toxic metabolites of tamoxifen analogues: droloxifene and toremifene o-quinones.
Chemical research in toxicology 2001;14(12):1643-53.
2001: Benjamin M Johnson; Judy L Bolton; Richard B Van Breemen
Screening botanical extracts for quinoid metabolites.
Chemical research in toxicology 2001;14(11):1546-51.
2001: Fagen Zhang; Dan Yao; Yousheng Hua; Richard B Van Breemen; Judy L Bolton
Synthesis and reactivity of the catechol metabolites from the equine estrogen, 8,9-dehydroestrone.
Chemical research in toxicology 2001;14(6):754-63.
2001: Peter Fan; Judy L Bolton
Bioactivation of tamoxifen to metabolite E quinone methide: reaction with glutathione and DNA.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(6):891-6.
2001: Jianhua Liu; Joanna E Burdette; Haiyan Xu; C Gu; Richard B Van Breemen; Krishna P L Bhat; Nancy Booth; Andreas I Constantinou; John M Pezzuto; Harry H S Fong; Norman R Farnsworth; Judy L Bolton
Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms.
Journal of agricultural and food chemistry 2001;49(5):2472-9.
2001: David C Spink; F Zhang; Mirza M Hussain; Barbara H Katz; Xuemei Liu; D R Hilker; Judy L Bolton
Metabolism of equilenin in MCF-7 and MDA-MB-231 human breast cancer cells.
Chemical research in toxicology 2001;14(5):572-81.
2001: Minsun Chang; Young Geun Shin; Richard B Van Breemen; Sylvie Blond; Judy L Bolton
Structural and functional consequences of inactivation of human glutathione S-transferase P1-1 mediated by the catechol metabolite of equine estrogens, 4-hydroxyequilenin.
Biochemistry 2001;40(15):4811-20.
2001: Judy L Bolton; Minsun Chang
Quinoids as reactive intermediates in estrogen carcinogenesis.
Advances in experimental medicine and biology 2001;500():497-507.
2001: Emily Pisha; Xuemei Liu; Andreas I Constantinou; Judy L Bolton
Evidence that a metabolite of equine estrogens, 4-hydroxyequilenin, induces cellular transformation in vitro.
Chemical research in toxicology 2001;14(1):82-90.
2001: Y Hua; S B Wainhaus; Y Yang; L Shen; Y Xiong; X Xu; F Zhang; Judy L Bolton; Richard B Van Breemen
Comparison of negative and positive ion electrospray tandem mass spectrometry for the liquid chromatography tandem mass spectrometry analysis of oxidized deoxynucleosides.
Journal of the American Society for Mass Spectrometry 2001;12(1):80-7.
2000: K H Cho; John M Pezzuto; Judy L Bolton; Vernon E Steele; Gary J Kelloff; Sang Kook Lee; Andreas I Constantinou
Selection of cancer chemopreventive agents based on inhibition of topoisomerase II activity.
European journal of cancer (Oxford, England : 1990) 2000;36(16):2146-56.
2000: Ying Chen; Xuemei Liu; Emily Pisha; Andreas I Constantinou; Yousheng Hua; L Shen; Richard B Van Breemen; Ebrahim Elguindi; Sylvie Blond; Fagen Zhang; Judy L Bolton
A metabolite of equine estrogens, 4-hydroxyequilenin, induces DNA damage and apoptosis in breast cancer cell lines.
Chemical research in toxicology 2000;13(5):342-50.
2000: Judy L Bolton; Michael A Trush; T M Penning; G Dryhurst; T J Monks
Role of quinones in toxicology.
Chemical research in toxicology 2000;13(3):135-60.
2000: Fagen Zhang; Peter Fan; Xuemei Liu; L Shen; R B van Breeman; Judy L Bolton
Synthesis and reactivity of a potential carcinogenic metabolite of tamoxifen: 3,4-dihydroxytamoxifen-o-quinone.
Chemical research in toxicology 2000;13(1):53-62.
2000: Peter Fan; Fagen Zhang; Judy L Bolton
4-Hydroxylated metabolites of the antiestrogens tamoxifen and toremifene are metabolized to unusually stable quinone methides.
Chemical research in toxicology 2000;13(1):45-52.
1999: Minsun Chang; Judy L Bolton; Sylvie Blond
Expression and purification of hexahistidine-tagged human glutathione S-transferase P1-1 in Escherichia coli.
Protein expression and purification 1999;17(3):443-8.
1999: Dejan Nikolic; Peter Fan; Judy L Bolton; Richard B Van Breemen
Screening for xenobiotic electrophilic metabolites using pulsed ultrafiltration-mass spectrometry.
Combinatorial chemistry & high throughput screening 1999;2(3):165-75.
1999: Fagen Zhang; Ying Chen; Emily Pisha; L Shen; Y Xiong; Richard B Van Breemen; Judy L Bolton
The major metabolite of equilin, 4-hydroxyequilin, autoxidizes to an o-quinone which isomerizes to the potent cytotoxin 4-hydroxyequilenin-o-quinone.
Chemical research in toxicology 1999;12(2):204-13.
1999: Fagen Zhang; Judy L Bolton
Synthesis of the equine estrogen metabolites 2-hydroxyequilin and 2-hydroxyequilenin.
Chemical research in toxicology 1999;12(2):200-3.
1998: Judy L Bolton; Emily Pisha; Fagen Zhang; S Qiu
Role of quinoids in estrogen carcinogenesis.
Chemical research in toxicology 1998;11(10):1113-27.
1998: Ying Chen; L Shen; Fagen Zhang; S S Lau; Richard B Van Breemen; Dejan Nikolic; Judy L Bolton
The equine estrogen metabolite 4-hydroxyequilenin causes DNA single-strand breaks and oxidation of DNA bases in vitro.
Chemical research in toxicology 1998;11(9):1105-11.
1998: Minsun Chang; Fagen Zhang; L Shen; N Pauss; I Alam; Richard B Van Breemen; Sylvie Blond; Judy L Bolton
Inhibition of glutathione S-transferase activity by the quinoid metabolites of equine estrogens.
Chemical research in toxicology 1998;11(7):758-65.
1998: Manickam Sugumaran; Judy L Bolton
Laccase--and not tyrosinase--is the enzyme responsible for quinone methide production from 2,6-dimethoxy-4-allyl phenol.
Archives of biochemistry and biophysics 1998;353(2):207-12.
1998: L Shen; S Qiu; Ying Chen; Fagen Zhang; Richard B Van Breemen; Dejan Nikolic; Judy L Bolton
Alkylation of 2'-deoxynucleosides and DNA by the Premarin metabolite 4-hydroxyequilenin semiquinone radical.
Chemical research in toxicology 1998;11(2):94-101.
1998: Richard B Van Breemen; Dejan Nikolic; Judy L Bolton
Metabolic screening using on-line ultrafiltration mass spectrometry.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(2):85-90.
1997: Judy L Bolton; S B Turnipseed; J A Thompson
Influence of quinone methide reactivity on the alkylation of thiol and amino groups in proteins: studies utilizing amino acid and peptide models.
Chemico-biological interactions 1997;107(3):185-200.
1997: Judy L Bolton; Emily Pisha; L Shen; ES Krol; S L Iverson; Z Huang; Richard B Van Breemen; John M Pezzuto
The reactivity of o-quinones which do not isomerize to quinone methides correlates with alkylcatechol-induced toxicity in human melanoma cells.
Chemico-biological interactions 1997;106(2):133-48.
1997: K V Ramakrishna; Peter Fan; C S Boyer; D Dalvie; Judy L Bolton
Oxo substituents markedly alter the phase II metabolism of alpha-hydroxybutenylbenzenes: models probing the bioactivation mechanisms of tamoxifen.
Chemical research in toxicology 1997;10(8):887-94.
1997: L Shen; Emily Pisha; Z Huang; John M Pezzuto; ES Krol; Z Alam; Richard B Van Breemen; Judy L Bolton
Bioreductive activation of catechol estrogen-ortho-quinones: aromatization of the B ring in 4-hydroxyequilenin markedly alters quinoid formation and reactivity.
Carcinogenesis 1997;18(5):1093-101.
1997: ES Krol; Judy L Bolton
Oxidation of 4-alkylphenols and catechols by tyrosinase: ortho-substituents alter the mechanism of quinoid formation.
Chemico-biological interactions 1997;104(1):11-27.
1996: M A Lewis; D G Yoerg; Judy L Bolton; John A Thompson
Alkylation of 2'-deoxynucleosides and DNA by quinone methides derived from 2,6-di-tert-butyl-4-methylphenol.
Chemical research in toxicology 1996;9(8):1368-74.
1996: T F Dowsley; J B Ulreich; Judy L Bolton; S S Park; Poh-Gek Forkert
CYP2E1-dependent bioactivation of 1,1-dichloroethylene in murine lung: formation of reactive intermediates and glutathione conjugates.
Toxicology and applied pharmacology 1996;139(1):42-8.
1996: Judy L Bolton; L Shen
p-Quinone methides are the major decomposition products of catechol estrogen o-quinones.
Carcinogenesis 1996;17(5):925-9.
1996: S L Iverson; L Shen; N Anlar; Judy L Bolton
Bioactivation of estrone and its catechol metabolites to quinoid-glutathione conjugates in rat liver microsomes.
Chemical research in toxicology 1996;9(2):492-9.
1996: Judy L Bolton; H M Wu; L Q Hu
Mechanism of isomerization of 4-propyl-o-quinone to its tautomeric p-quinone methide.
Chemical research in toxicology 1996;9(1):109-113.
1995: S L Iverson; L Q Hu; V Vukomanovic; Judy L Bolton
The influence of the p-alkyl substituent on the isomerization of o-quinones to p-quinone methides: potential bioactivation mechanism for catechols.
Chemical research in toxicology 1995;8(4):537-44.
1995: Judy L Bolton; E Comeau; V Vukomanovic
The influence of 4-alkyl substituents on the formation and reactivity of 2-methoxy-quinone methides: evidence that extended pi-conjugation dramatically stabilizes the quinone methide formed from eugenol.
Chemico-biological interactions 1995;95(3):279-90.
1995: T F Dowsley; Poh-Gek Forkert; L A Benesch; Judy L Bolton
Reaction of glutathione with the electrophilic metabolites of 1,1-dichloroethylene.
Chemico-biological interactions 1995;95(3):227-44.
1995: D C Thompson; K Perera; E S Krol; Judy L Bolton
o-Methoxy-4-alkylphenols that form quinone methides of intermediate reactivity are the most toxic in rat liver slices.
Chemical research in toxicology 1995;8(3):323-7.
1994: Judy L Bolton; N M Acay; V Vukomanovic
Evidence that 4-allyl-o-quinones spontaneously rearrange to their more electrophilic quinone methides: potential bioactivation mechanism for the hepatocarcinogen safrole.
Chemical research in toxicology 1994;7(3):443-50.
1993: Judy L Bolton; John A Thompson; A J Allentoff; F B Miley; Alvin M Malkinson
Metabolic activation of butylated hydroxytoluene by mouse bronchiolar Clara cells.
Toxicology and applied pharmacology 1993;123(1):43-9.
1992: Judy L Bolton; LG Valerio; John A Thompson
The enzymatic formation and chemical reactivity of quinone methides correlate with alkylphenol-induced toxicity in rat hepatocytes.
Chemical research in toxicology 1992;5(6):816-22.
1991: J A Thompson; Judy L Bolton; Alvin M Malkinson
Relationship between the metabolism of butylated hydroxytoluene (BHT) and lung tumor promotion in mice.
Experimental lung research 1991;17(2):439-53.
1991: Judy L Bolton; J A Thompson
Oxidation of butylated hydroxytoluene to toxic metabolites. Factors influencing hydroxylation and quinone methide formation by hepatic and pulmonary microsomes.
Drug metabolism and disposition: the biological fate of chemicals 1991;19(2):467-72.
1991: J A Thompson; Judy L Bolton; K M Schullek; H Sevestre
Bioactivation of 2,6-di-tert-butyl-4-methyl phenol (BHT) and hydroxylated analogues to toxic quinoid metabolites.
Advances in experimental medicine and biology 1991;283():393-8.
1990: Judy L Bolton; H Sevestre; B O Ibe; J A Thompson
Formation and reactivity of alternative quinone methides from butylated hydroxytoluene: possible explanation for species-specific pneumotoxicity.
Chemical research in toxicology 1990;3(1):65-70.