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Judy Bolton
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46
Van Breemen, Richard
20
Farnsworth, Norman
19
Thatcher, Gregory
15
Zhang, Fagen
13
Nikolic, Dejan
13
Pauli, Guido
11
Overk, Cassia
11
Pisha, Emily
11
Burdette, Joanna
11
Chang, Minsun
11
Liu, Xuemei
11
Yao, Ping
10
Shen, L
9
Pezzuto, John
9
Li, Yan
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All Publications
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2009: Geller Stacie E; Shulman Lee P; van Breemen Richard B; Banuvar Suzanne; Zhou Ying; Epstein Geena; Hedayat Samad; Nikolic Dejan; Krause Elizabeth C; Piersen Colleen E; Bolton Judy L; Pauli Guido F; Farnsworth Norman R
Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms: a randomized controlled trial.
Menopause (New York, N.Y.) 2009;16(6):1156-66.
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2009: Wang Zhican; Edirisinghe Praneeth; Sohn Johann; Qin Zhihui; Geacintov Nicholas E; Thatcher Gregory R J; Bolton Judy L
Development of a liquid chromatography electrospray ionization tandem mass spectrometry method for analysis of stable 4-hydroxyequilenin-DNA adducts in human breast cancer cells.
Chemical research in toxicology 2009;22(6):1129-36.
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2009: Yu Bolan; Qin Zhihui; Wijewickrama Gihani T; Edirisinghe Praneeth; Bolton Judy L; Thatcher Gregory R J
Comparative methods for analysis of protein covalent modification by electrophilic quinoids formed from xenobiotics.
Bioconjugate chemistry 2009;20(4):728-41.
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2009: Wang Zhican; Wijewickrama Gihani T; Peng Kuan-Wei; Dietz Birgit M; Yuan Long; van Breemen Richard B; Bolton Judy L; Thatcher Gregory R J
Estrogen Receptor {alpha} Enhances the Rate of Oxidative DNA Damage by Targeting an Equine Estrogen Catechol Metabolite to the Nucleus.
The Journal of biological chemistry 2009;284(13):8633-42.
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2009: Gödecke Tanja; Nikolic Dejan; Lankin David C; Chen Shao-Nong; Powell Sharla L; Dietz Birgit; Bolton Judy L; van Breemen Richard B; Farnsworth Norman R; Pauli Guido F
Phytochemistry of cimicifugic acids and associated bases in Cimicifuga racemosa root extracts.
Phytochemical analysis : PCA 2009;20(2):120-33.
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2008: Powell Sharla L; Gödecke Tanja; Nikolic Dejan; Chen Shao-Nong; Ahn Soyoun; Dietz Birgit; Farnsworth Norman R; van Breemen Richard B; Lankin David C; Pauli Guido F; Bolton Judy L
In vitro serotonergic activity of black cohosh and identification of N(omega)-methylserotonin as a potential active constituent.
Journal of agricultural and food chemistry 2008;56(24):11718-26.
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2008: Dietz Birgit M; Liu Dongting; Hagos Ghenet K; Yao Ping; Schinkovitz Andreas; Pro Samuel M; Deng Shixin; Farnsworth Norman R; Pauli Guido F; van Breemen Richard B; Bolton Judy L
Angelica sinensis and its alkylphthalides induce the detoxification enzyme NAD(P)H: quinone oxidoreductase 1 by alkylating Keap1.
Chemical research in toxicology 2008;21(10):1939-48.
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2008: Overk Cassia R; Guo Jian; Chadwick Lucas R; Lantvit Daniel D; Minassi Alberto; Appendino Giovanni; Chen Shao-Nong; Lankin David C; Farnsworth Norman R; Pauli Guido F; van Breemen Richard B; Bolton Judy L
In vivo estrogenic comparisons of Trifolium pratense (red clover) Humulus lupulus (hops), and the pure compounds isoxanthohumol and 8-prenylnaringenin.
Chemico-biological interactions 2008;176(1):30-9.
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2008: Chandrasena R Esala P; Edirisinghe Praneeth D; Bolton Judy L; Thatcher Gregory R J
Problematic detoxification of estrogen quinones by NAD(P)H-dependent quinone oxidoreductase and glutathione-S-transferase.
Chemical research in toxicology 2008;21(7):1324-9.
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2008: Overk Cassia R; Yao Ping; Chen Shaonong; Deng Shixing; Imai Ayano; Main Matthew; Schinkovitz Andreas; Farnsworth Norman R; Pauli Guido F; Bolton Judy L
High-content screening and mechanism-based evaluation of estrogenic botanical extracts.
Combinatorial chemistry & high throughput screening 2008;11(4):283-93.
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2008: Farnsworth Norman R; Krause Elizabeth C; Bolton Judy L; Pauli Guido F; van Breemen Richard B; Graham James G
The University of Illinois at Chicago/National Institutes of Health Center for Botanical Dietary Supplements Research for Women's Health: from plant to clinical use.
The American journal of clinical nutrition 2008;87(2):504S-8S.
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2008: Bolton Judy L; Thatcher Gregory R J
Potential mechanisms of estrogen quinone carcinogenesis.
Chemical research in toxicology 2008;21(1):93-101.
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2008: Chang Minsun; Overk Cassia R; Kastrati Irida; Peng Kuan-wei; Yao Ping; Qin Zhi-Hui; Petukhov Pavel; Bolton Judy L; Thatcher Gregory R J
Estrogenic activity of the equine estrogen metabolite, 4-methoxyequilenin.
Advances in experimental medicine and biology 2008;617():601-7.
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2007: Liu Hong; Qin Zhihui; Thatcher Gregory R J; Bolton Judy L
Uterine peroxidase-catalyzed formation of diquinone methides from the selective estrogen receptor modulators raloxifene and desmethylated arzoxifene.
Chemical research in toxicology 2007;20(11):1676-84.
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2007: Michel Joanna; Duarte Reinel Eduardo; Bolton Judy L; Huang Yue; Caceres Armando; Veliz Mario; Soejarto Djaja Doel; Mahady Gail B
Medical potential of plants used by the Q'eqchi Maya of Livingston, Guatemala for the treatment of women's health complaints.
Journal of ethnopharmacology 2007;114(1):92-101.
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2007: Overk Cassia R; Peng Kuan-Wei; Asghodom Rezene T; Kastrati Irida; Lantvit Daniel D; Qin Zhihui; Frasor Jonna; Bolton Judy L; Thatcher Gregory R J
Structure-activity relationships for a family of benzothiophene selective estrogen receptor modulators including raloxifene and arzoxifene.
ChemMedChem 2007;2(10):1520-6.
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2007: Chang Minsun; Peng Kuan-wei; Kastrati Irida; Overk Cassia R; Qin Zhi-Hui; Yao Ping; Bolton Judy L; Thatcher Gregory R J
Activation of estrogen receptor-mediated gene transcription by the equine estrogen metabolite, 4-methoxyequilenin, in human breast cancer cells.
Endocrinology 2007;148(10):4793-802.
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2007: Yu Bolan; Dietz Birgit M; Dunlap Tareisha; Kastrati Irida; Lantvit Daniel D; Overk Cassia R; Yao Ping; Qin Zhihui; Bolton Judy L; Thatcher Gregory R J
Structural modulation of reactivity/activity in design of improved benzothiophene selective estrogen receptor modulators: induction of chemopreventive mechanisms.
Molecular cancer therapeutics 2007;6(9):2418-28.
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2007: Qin Zhihui; Kastrati Irida; Chandrasena R Esala P; Liu Hong; Yao Ping; Petukhov Pavel A; Bolton Judy L; Thatcher Gregory R J
Benzothiophene selective estrogen receptor modulators with modulated oxidative activity and receptor affinity.
Journal of medicinal chemistry 2007;50(11):2682-92.
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2007: Dietz Birgit; Bolton Judy L
Botanical dietary supplements gone bad.
Chemical research in toxicology 2007;20(4):586-90.
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2006: Dowers Tamara S; Qin Zhi-Hui; Thatcher Gregory R J; Bolton Judy L
Bioactivation of Selective Estrogen Receptor Modulators (SERMs).
Chemical research in toxicology 2006;19(9):1125-37.
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2006: Cuendet Muriel; Bolton Judy L
Response of human mammary epithelial cells to DNA damage induced by 4-hydroxyequilenin: Lack of p53-mediated G1 arrest.
Chemico-biological interactions 2006;161(3):271-8.
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2006: Liu Hong; Bolton Judy L; Thatcher Gregory R J
Chemical modification modulates estrogenic activity, oxidative reactivity, and metabolic stability in 4'F-DMA, a new benzothiophene selective estrogen receptor modulator.
Chemical research in toxicology 2006;19(6):779-87.
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2006: Deng Shixin; Chen Shao-Nong; Yao Ping; Nikolic Dejan; van Breemen Richard B; Bolton Judy L; Fong Harry H S; Farnsworth Norman R; Pauli Guido F
Serotonergic activity-guided phytochemical investigation of the roots of Angelica sinensis.
Journal of natural products 2006;69(4):536-41.
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2006: Booth Nancy L; Overk Cassia R; Yao Ping; Burdette Joanna E; Nikolic Dejan; Chen Shao-Nong; Bolton Judy L; van Breemen Richard B; Pauli Guido F; Farnsworth Norman R
The chemical and biologic profile of a red clover (Trifolium pratense L.) phase II clinical extract.
Journal of alternative and complementary medicine (New York, N.Y.) 2006;12(2):133-9.
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2006: Gafner Stefan; Dietz Birgit M; McPhail Kerry L; Scott Ian M; Glinski Jan A; Russell Fiona E; McCollom Megan M; Budzinski Jason W; Foster Brian C; Bergeron Chantal; Rhyu Mee-Ra; Bolton Judy L
Alkaloids from Eschscholzia californica and their capacity to inhibit binding of [3H]8-Hydroxy-2-(di-N-propylamino)tetralin to 5-HT1A receptors in Vitro.
Journal of natural products 2006;69(3):432-5.
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2006: Booth Nancy L; Overk Cassia R; Yao Ping; Totura Steve; Deng Yunfan; Hedayat A S; Bolton Judy L; Pauli Guido F; Farnsworth Norman R
Seasonal variation of red clover (Trifolium pratense L., Fabaceae) isoflavones and estrogenic activity.
Journal of agricultural and food chemistry 2006;54(4):1277-82.
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2005: Li Yan; Yang Xiaofeng; van Breemen Richard B; Bolton Judy L
Characterization of two new variants of human catechol O-methyltransferase in vitro.
Cancer letters 2005;230(1):81-9.
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2005: Liu Guowen; Eggler Aimee L; Dietz Birgit M; Mesecar Andrew D; Bolton Judy L; Pezzuto John M; van Breemen Richard B
Screening method for the discovery of potential cancer chemoprevention agents based on mass spectrometric detection of alkylated Keap1.
Analytical chemistry 2005;77(19):6407-14.
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2005: Liu Ju; Li Qian; Yang Xiaofeng; van Breemen Richard B; Bolton Judy L; Thatcher Gregory R J
Analysis of protein covalent modification by xenobiotics using a covert oxidatively activated tag: raloxifene proof-of-principle study.
Chemical research in toxicology 2005;18(9):1485-96.
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2005: Dietz Birgit M; Kang Young-Hwa; Liu Guowen; Eggler Aimee L; Yao Ping; Chadwick Lucas R; Pauli Guido F; Farnsworth Norman R; Mesecar Andrew D; van Breemen Richard B; Bolton Judy L
Xanthohumol isolated from Humulus lupulus Inhibits menadione-induced DNA damage through induction of quinone reductase.
Chemical research in toxicology 2005;18(8):1296-305.
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2005: Overk Cassia R; Yao Ping; Chadwick Lucas R; Nikolic Dejan; Sun Yongkai; Cuendet Muriel A; Deng Yunfan; Hedayat A S; Pauli Guido F; Farnsworth Norman R; van Breemen Richard B; Bolton Judy L
Comparison of the in vitro estrogenic activities of compounds from hops (Humulus lupulus) and red clover (Trifolium pratense).
Journal of agricultural and food chemistry 2005;53(16):6246-53.
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2005: Li Yan; Yang Xiaofeng; Chang Minsun; Yager James D; van Breemen Richard B; Bolton Judy L
Functional and structural comparisons of cysteine residues in the Val108 wild type and Met108 variant of human soluble catechol O-methyltransferase.
Chemico-biological interactions 2005;152(2-3):151-63.
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2005: Liu Ju; Liu Hong; van Breemen Richard B; Thatcher Gregory R J; Bolton Judy L
Bioactivation of the selective estrogen receptor modulator acolbifene to quinone methides.
Chemical research in toxicology 2005;18(2):174-82.
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2005: Liu Hong; Liu Ju; van Breemen Richard B; Thatcher Gregory R J; Bolton Judy L
Bioactivation of the selective estrogen receptor modulator desmethylated arzoxifene to quinoids: 4'-fluoro substitution prevents quinoid formation.
Chemical research in toxicology 2005;18(2):162-73.
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2005: Sun Yongkai; Gu Chungang; Liu Xuemei; Liang Wenzhong; Yao Ping; Bolton Judy L; van Breemen Richard B
Ultrafiltration tandem mass spectrometry of estrogens for characterization of structure and affinity for human estrogen receptors.
Journal of the American Society for Mass Spectrometry 2005;16(2):271-9.
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2004: Chadwick Lucas R; Nikolic Dejan; Burdette Joanna E; Overk Cassia R; Bolton Judy L; van Breemen Richard B; Fröhlich Roland; Fong Harry H S; Farnsworth Norman R; Pauli Guido F
Estrogens and congeners from spent hops (Humulus lupulus).
Journal of natural products 2004;67(12):2024-32.
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2004: Li Yan; Yao Jiaqin; Chang Minsun; Cuendet Muriel; Bolton Judy L
Altered apoptotic response in MCF 10A cells treated with the equine estrogen metabolite, 4-hydroxyequilenin.
Toxicology letters 2004;154(3):225-33.
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2004: Yu Linning; Liu Hong; Li Wenkui; Zhang Fagen; Luckie Connie; van Breemen Richard B; Thatcher Gregory R J; Bolton Judy L
Oxidation of raloxifene to quinoids: potential toxic pathways via a diquinone methide and o-quinones.
Chemical research in toxicology 2004;17(7):879-88.
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2004: Piersen C E; Booth N L; Sun Y; Liang W; Burdette J E; van Breemen R B; Geller S E; Gu C; Banuvar S; Shulman L P; Bolton J L; Farnsworth N R
Chemical and biological characterization and clinical evaluation of botanical dietary supplements: a phase I red clover extract as a model.
Current medicinal chemistry 2004;11(11):1361-74.
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2004: Cuendet Muriel; Liu Xuemei; Pisha Emily; Li Yan; Yao Jiaqin; Yu Linning; Bolton Judy L
Equine estrogen metabolite 4-hydroxyequilenin induces anchorage-independent growth of human mammary epithelial MCF-10A cells: differential gene expression.
Mutation research 2004;550(1-2):109-21.
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2004: Li Yan; Yao Jiaqin; Chang Minsun; Nikolic Dejan; Yu Linning; Yager James D; Mesecar Andrew D; van Breemen Richard B; Bolton Judy L
Equine catechol estrogen 4-hydroxyequilenin is a more potent inhibitor of the variant form of catechol-O-methyltransferase.
Chemical research in toxicology 2004;17(4):512-20.
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2004: Liu J; Burdette J E; Sun Y; Deng S; Schlecht S M; Zheng W; Nikolic D; Mahady G; van Breemen R B; Fong H H S; Pezzuto J M; Bolton J L; Farnsworth N R
Isolation of linoleic acid as an estrogenic compound from the fruits of Vitex agnus-castus L. (chaste-berry).
Phytomedicine : international journal of phytotherapy and phytopharmacology 2004;11(1):18-23.
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2004: Bolton Judy L; Yu Linning; Thatcher Gregory R J
Quinoids formed from estrogens and antiestrogens.
Methods in enzymology 2004;378():110-23.
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2003: Toader Violeta; Xu Xudong; Nicolescu Adrian; Yu Linning; Bolton Judy L; Thatcher Gregory R J
Nitrosation, nitration, and autoxidation of the selective estrogen receptor modulator raloxifene by nitric oxide, peroxynitrite, and reactive nitrogen/oxygen species.
Chemical research in toxicology 2003;16(10):1264-76.
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2003: Burdette Joanna E; Liu Jianghua; Chen Shao-Nong; Fabricant Daniel S; Piersen Colleen E; Barker Eric L; Pezzuto John M; Mesecar Andrew; Van Breemen Richard B; Farnsworth Norman R; Bolton Judy L
Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor.
Journal of agricultural and food chemistry 2003;51(19):5661-70.
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2003: Liu Xuemei; Pisha Emily; Tonetti Debra A; Yao Dan; Li Yan; Yao Jiaqin; Burdette Joanna E; Bolton Judy L
Antiestrogenic and DNA damaging effects induced by tamoxifen and toremifene metabolites.
Chemical research in toxicology 2003;16(7):832-7.
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2003: Liu Xuemei; Zhang Fagen; Liu Hong; Burdette Joanna E; Li Yan; Overk Cassia R; Pisha Emily; Yao Jiaqin; van Breemen Richard B; Swanson Steven M; Bolton Judy L
Effect of halogenated substituents on the metabolism and estrogenic effects of the equine estrogen, equilenin.
Chemical research in toxicology 2003;16(6):741-9.
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2003: Johnson Benjamin M; Qiu Sheng-Xiang; Zhang Shide; Zhang Fagen; Burdette Joanna E; Yu Linning; Bolton Judy L; van Breemen Richard B
Identification of novel electrophilic metabolites of piper methysticum Forst (Kava).
Chemical research in toxicology 2003;16(6):733-40.
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2003: Yao Jiaqin; Li Yan; Chang Minsun; Wu Huaping; Yang Xiaofeng; Goodman Julie E; Liu Xuemei; Liu Hong; Mesecar Andrew D; Van Breemen Richard B; Yager James D; Bolton Judy L
Catechol estrogen 4-hydroxyequilenin is a substrate and an inhibitor of catechol-O-methyltransferase.
Chemical research in toxicology 2003;16(5):668-75.
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2002: Xu H; Fabricant D S; Piersen C E; Bolton J L; Pezzuto J M; Fong H; Totura S; Farnsworth N R; Constantinou A I
A preliminary RAPD-PCR analysis of Cimicifuga species and other botanicals used for women's health.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2002;9(8):757-62.
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2002: Burdette Joanna E; Chen Shao-Nong; Lu Zhi-Zhen; Xu Haiyan; White Bethany E P; Fabricant Daniel S; Liu Jianghua; Fong Harry H S; Farnsworth Norman R; Constantinou Andreas I; Van Breemen Richard B; Pezzuto John M; Bolton Judy L
Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: bioassay-directed isolation and characterization of active principles.
Journal of agricultural and food chemistry 2002;50(24):7022-8.
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2002: Bolton Judy L
Quinoids, quinoid radicals, and phenoxyl radicals formed from estrogens and antiestrogens.
Toxicology 2002;177(1):55-65.
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2002: Yao Jiaqin; Chang Minsun; Li Yan; Pisha Emily; Liu Xuemei; Yao Dan; Elguindi Ebrahim C; Blond Sylvie Y; Bolton Judy L
Inhibition of cellular enzymes by equine catechol estrogens in human breast cancer cells: specificity for glutathione S-transferase P1-1.
Chemical research in toxicology 2002;15(7):935-42.
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2002: Liu Xuemei; Yao Jiaqin; Pisha Emily; Yang Yanan; Hua Yousheng; van Breemen Richard B; Bolton Judy L
Oxidative DNA damage induced by equine estrogen metabolites: role of estrogen receptor alpha.
Chemical research in toxicology 2002;15(4):512-9.
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2002: Geun Shin Young; Bolton Judy L; van Breemen Richard B
Screening drugs for metabolic stability using pulsed ultrafiltration mass spectrometry.
Combinatorial chemistry & high throughput screening 2002;5(1):59-64.
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2002: Burdette Joanna E; Liu Jianghua; Lantvit Dan; Lim Eula; Booth Nancy; Bhat Krishna P L; Hedayat Samad; Van Breemen Richard B; Constantinou Andreas I; Pezzuto John M; Farnsworth Norman R; Bolton Judy L
Trifolium pratense (red clover) exhibits estrogenic effects in vivo in ovariectomized Sprague-Dawley rats.
The Journal of nutrition 2002;132(1):27-30.
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2001: Zhang F; Swanson S M; van Breemen R B; Liu X; Yang Y; Gu C; Bolton J L
Equine estrogen metabolite 4-hydroxyequilenin induces DNA damage in the rat mammary tissues: formation of single-strand breaks, apurinic sites, stable adducts, and oxidized bases.
Chemical research in toxicology 2001;14(12):1654-9.
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2001: Yao D; Zhang F; Yu L; Yang Y; van Breemen R B; Bolton J L
Synthesis and reactivity of potential toxic metabolites of tamoxifen analogues: droloxifene and toremifene o-quinones.
Chemical research in toxicology 2001;14(12):1643-53.
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2001: Johnson B M; Bolton J L; van Breemen R B
Screening botanical extracts for quinoid metabolites.
Chemical research in toxicology 2001;14(11):1546-51.
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2001: Zhang F; Yao D; Hua Y; van Breemen R B; Bolton J L
Synthesis and reactivity of the catechol metabolites from the equine estrogen, 8,9-dehydroestrone.
Chemical research in toxicology 2001;14(6):754-63.
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2001: Fan P W; Bolton J L
Bioactivation of tamoxifen to metabolite E quinone methide: reaction with glutathione and DNA.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(6):891-6.
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2001: Liu J; Burdette J E; Xu H; Gu C; van Breemen R B; Bhat K P; Booth N; Constantinou A I; Pezzuto J M; Fong H H; Farnsworth N R; Bolton J L
Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms.
Journal of agricultural and food chemistry 2001;49(5):2472-9.
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2001: Chang M; Shin Y G; van Breemen R B; Blond S Y; Bolton J L
Structural and functional consequences of inactivation of human glutathione S-transferase P1-1 mediated by the catechol metabolite of equine estrogens, 4-hydroxyequilenin.
Biochemistry 2001;40(15):4811-20.
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2001: Pisha E; Lui X; Constantinou A I; Bolton J L
Evidence that a metabolite of equine estrogens, 4-hydroxyequilenin, induces cellular transformation in vitro.
Chemical research in toxicology 2001;14(1):82-90.
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2001: Hua Y; Wainhaus S B; Yang Y; Shen L; Xiong Y; Xu X; Zhang F; Bolton J L; van Breemen R B
Comparison of negative and positive ion electrospray tandem mass spectrometry for the liquid chromatography tandem mass spectrometry analysis of oxidized deoxynucleosides.
Journal of the American Society for Mass Spectrometry 2001;12(1):80-7.
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2001: Bolton J L; Chang M
Quinoids as reactive intermediates in estrogen carcinogenesis.
Advances in experimental medicine and biology 2001;500():497-507.
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2000: Chen Y; Liu X; Pisha E; Constantinou A I; Hua Y; Shen L; van Breemen R B; Elguindi E C; Blond S Y; Zhang F; Bolton J L
A metabolite of equine estrogens, 4-hydroxyequilenin, induces DNA damage and apoptosis in breast cancer cell lines.
Chemical research in toxicology 2000;13(5):342-50.
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2000: Bolton J L; Trush M A; Penning T M; Dryhurst G; Monks T J
Role of quinones in toxicology.
Chemical research in toxicology 2000;13(3):135-60.
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2000: Zhang F; Fan P W; Liu X; Shen L; van Breeman R B; Bolton J L
Synthesis and reactivity of a potential carcinogenic metabolite of tamoxifen: 3,4-dihydroxytamoxifen-o-quinone.
Chemical research in toxicology 2000;13(1):53-62.
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2000: Fan P W; Zhang F; Bolton J L
4-Hydroxylated metabolites of the antiestrogens tamoxifen and toremifene are metabolized to unusually stable quinone methides.
Chemical research in toxicology 2000;13(1):45-52.
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1999: Chang M; Bolton J L; Blond S Y
Expression and purification of hexahistidine-tagged human glutathione S-transferase P1-1 in Escherichia coli.
Protein expression and purification 1999;17(3):443-8.
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1999: Nikolic D; Fan P W; Bolton J L; van Breemen R B
Screening for xenobiotic electrophilic metabolites using pulsed ultrafiltration-mass spectrometry.
Combinatorial chemistry & high throughput screening 1999;2(3):165-75.
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1999: Zhang F; Chen Y; Pisha E; Shen L; Xiong Y; van Breemen R B; Bolton J L
The major metabolite of equilin, 4-hydroxyequilin, autoxidizes to an o-quinone which isomerizes to the potent cytotoxin 4-hydroxyequilenin-o-quinone.
Chemical research in toxicology 1999;12(2):204-13.
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1999: Zhang F; Bolton J L
Synthesis of the equine estrogen metabolites 2-hydroxyequilin and 2-hydroxyequilenin.
Chemical research in toxicology 1999;12(2):200-3.
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1998: Bolton J L; Pisha E; Zhang F; Qiu S
Role of quinoids in estrogen carcinogenesis.
Chemical research in toxicology 1998;11(10):1113-27.
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1998: Chen Y; Shen L; Zhang F; Lau S S; van Breemen R B; Nikolic D; Bolton J L
The equine estrogen metabolite 4-hydroxyequilenin causes DNA single-strand breaks and oxidation of DNA bases in vitro.
Chemical research in toxicology 1998;11(9):1105-11.
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1998: Chang M; Zhang F; Shen L; Pauss N; Alam I; van Breemen R B; Blond S Y; Bolton J L
Inhibition of glutathione S-transferase activity by the quinoid metabolites of equine estrogens.
Chemical research in toxicology 1998;11(7):758-65.
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1998: Shen L; Qiu S; Chen Y; Zhang F; van Breemen R B; Nikolic D; Bolton J L
Alkylation of 2'-deoxynucleosides and DNA by the Premarin metabolite 4-hydroxyequilenin semiquinone radical.
Chemical research in toxicology 1998;11(2):94-101.
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1998: van Breemen R B; Nikolic D; Bolton J L
Metabolic screening using on-line ultrafiltration mass spectrometry.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(2):85-90.
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1997: Bolton J L; Turnipseed S B; Thompson J A
Influence of quinone methide reactivity on the alkylation of thiol and amino groups in proteins: studies utilizing amino acid and peptide models.
Chemico-biological interactions 1997;107(3):185-200.
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1997: Bolton J L; Pisha E; Shen L; Krol E S; Iverson S L; Huang Z; van Breemen R B; Pezzuto J M
The reactivity of o-quinones which do not isomerize to quinone methides correlates with alkylcatechol-induced toxicity in human melanoma cells.
Chemico-biological interactions 1997;106(2):133-48.
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1997: Ramakrishna K V; Fan P W; Boyer C S; Dalvie D; Bolton J L
Oxo substituents markedly alter the phase II metabolism of alpha-hydroxybutenylbenzenes: models probing the bioactivation mechanisms of tamoxifen.
Chemical research in toxicology 1997;10(8):887-94.
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1997: Shen L; Pisha E; Huang Z; Pezzuto J M; Krol E; Alam Z; van Breemen R B; Bolton J L
Bioreductive activation of catechol estrogen-ortho-quinones: aromatization of the B ring in 4-hydroxyequilenin markedly alters quinoid formation and reactivity.
Carcinogenesis 1997;18(5):1093-101.
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1997: Krol E S; Bolton J L
Oxidation of 4-alkylphenols and catechols by tyrosinase: ortho-substituents alter the mechanism of quinoid formation.
Chemico-biological interactions 1997;104(1):11-27.
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1996: Dowsley T F; Ulreich J B; Bolton J L; Park S S; Forkert P G
CYP2E1-dependent bioactivation of 1,1-dichloroethylene in murine lung: formation of reactive intermediates and glutathione conjugates.
Toxicology and applied pharmacology 1996;139(1):42-8.
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1996: Bolton J L; Shen L
p-Quinone methides are the major decomposition products of catechol estrogen o-quinones.
Carcinogenesis 1996;17(5):925-9.
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1996: Iverson S L; Shen L; Anlar N; Bolton J L
Bioactivation of estrone and its catechol metabolites to quinoid-glutathione conjugates in rat liver microsomes.
Chemical research in toxicology 1996;9(2):492-9.
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1996: Bolton J L; Wu H M; Hu L Q
Mechanism of isomerization of 4-propyl-o-quinone to its tautomeric p-quinone methide.
Chemical research in toxicology 1996;9(1):109-113.
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1995: Iverson S L; Hu L Q; Vukomanovic V; Bolton J L
The influence of the p-alkyl substituent on the isomerization of o-quinones to p-quinone methides: potential bioactivation mechanism for catechols.
Chemical research in toxicology 1995;8(4):537-44.
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1995: Bolton J L; Comeau E; Vukomanovic V
The influence of 4-alkyl substituents on the formation and reactivity of 2-methoxy-quinone methides: evidence that extended pi-conjugation dramatically stabilizes the quinone methide formed from eugenol.
Chemico-biological interactions 1995;95(3):279-90.
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1995: Dowsley T F; Forkert P G; Benesch L A; Bolton J L
Reaction of glutathione with the electrophilic metabolites of 1,1-dichloroethylene.
Chemico-biological interactions 1995;95(3):227-44.
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1995: Thompson D C; Perera K; Krol E S; Bolton J L
o-Methoxy-4-alkylphenols that form quinone methides of intermediate reactivity are the most toxic in rat liver slices.
Chemical research in toxicology 1995;8(3):323-7.
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1994: Bolton J L; Acay N M; Vukomanovic V
Evidence that 4-allyl-o-quinones spontaneously rearrange to their more electrophilic quinone methides: potential bioactivation mechanism for the hepatocarcinogen safrole.
Chemical research in toxicology 1994;7(3):443-50.
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