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Robert Stroud

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John S Ikonomidis; Charlotte R Ivey; Adam W Akerman; Giovanni Ferrari; Chad G Hughes; Rupak Mukherjee; Risha K Patel; Allison Rice; Asad A Shah; Robert E Stroud; Jason B Wheeler; Jeffrey A Jones
Plasma biomarkers for distinguishing etiologic subtypes of thoracic aortic aneurysm disease.
Shaina R Eckhouse; Jeffrey A Jones; Christina B Logdon; Rupak Mukherjee; Elizabeth K Nadeau; J Marshall Oelsen; Elizabeth C O'Quinn; Adam W Akerman; Robert E Stroud; Francis G Spinale
Differential membrane type 1 matrix metalloproteinase substrate processing with ischemia-reperfusion: relationship to interstitial microRNA dynamics and myocardial function.
Michael R Zile; Robert E Stroud; An Van Laer; Jazmine Arroyo; Catalin F Baicu; Jeffrey A Jones; Rupak Mukherjee; Francis G Spinale
Pressure overload-dependent membrane type 1-matrix metalloproteinase induction: relationship to LV remodeling and fibrosis.

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2013: John S Ikonomidis; Charlotte R Ivey; Adam W Akerman; Giovanni Ferrari; Chad G Hughes; Rupak Mukherjee; Risha K Patel; Allison Rice; Asad A Shah; Robert E Stroud; Jason B Wheeler; Jeffrey A Jones
Plasma biomarkers for distinguishing etiologic subtypes of thoracic aortic aneurysm disease.
The Journal of thoracic and cardiovascular surgery 2013;145(5):1326-33.
2013: Shaina R Eckhouse; Jeffrey A Jones; Christina B Logdon; Rupak Mukherjee; Elizabeth K Nadeau; J Marshall Oelsen; Elizabeth C O'Quinn; Adam W Akerman; Robert E Stroud; Francis G Spinale
Differential membrane type 1 matrix metalloproteinase substrate processing with ischemia-reperfusion: relationship to interstitial microRNA dynamics and myocardial function.
The Journal of thoracic and cardiovascular surgery 2013;145(1):267-275, 277.e1-4; discussion 275-7.
2012: Michael R Zile; Robert E Stroud; An Van Laer; Jazmine Arroyo; Catalin F Baicu; Jeffrey A Jones; Rupak Mukherjee; Francis G Spinale
Pressure overload-dependent membrane type 1-matrix metalloproteinase induction: relationship to LV remodeling and fibrosis.
American journal of physiology. Heart and circulatory physiology 2012;302(7):H1429-37.
2012: John S Ikonomidis; Jazmine Arroyo; Joseph E Bavaria; Stewart M Benton; Theresa A Brinsa; Joseph H Gorman; Robert Gorman; Jean Marie Ruddy; Francis G Spinale; Robert E Stroud; Ahmad Zeeshan; Jeffrey A Jones
Aortic dilatation with bicuspid aortic valves: cusp fusion correlates to matrix metalloproteinases and inhibitors.
The Annals of thoracic surgery 2012;93(2):457-63.
2011: Juozas A Zavadzkas; Robert E Stroud; Laurel E Black; Richard A McKinney; Evan C Meyer; Rupak Mukherjee; J Marshall Oelsen; Risha K Patel; William T Rivers; Francis G Spinale
Direct regulation of membrane type 1 matrix metalloproteinase following myocardial infarction causes changes in survival, cardiac function, and remodeling.
American journal of physiology. Heart and circulatory physiology 2011;301(4):H1656-66.
2011: Jennifer A Dixon; Joseph H Gorman; Robert C Gorman; Hirotsugu Hamamoto; Evan C Meyer; Masato Morita; Rupak Mukherjee; Liam P Ryan; Nathaniel L Baker; Robert E Stroud; Francis G Spinale
Targeted regional injection of biocomposite microspheres alters post-myocardial infarction remodeling and matrix proteolytic pathways.
Circulation 2011;124(11 Suppl):S35-45.
2011: Zakir H Sahul; Donald P Dione; Lawrence W Dobrucki; James S Duncan; Jarod McAteer; Rupak Mukherjee; Xenophon Papademetris; James Song; Francis G Spinale; Lawrence Staib; Robert E Stroud; Albert J Sinusas
Targeted imaging of the spatial and temporal variation of matrix metalloproteinase activity in a porcine model of postinfarct remodeling: relationship to myocardial dysfunction.
Circulation. Cardiovascular imaging 2011;4(4):381-91.
2011: Michael R Zile; Stacia M Desantis; Catalin F Baicu; Robert E Stroud; Sheila B Thompson; Catherine D McClure; Shannon M Mehurg; Francis G Spinale
Plasma biomarkers that reflect determinants of matrix composition identify the presence of left ventricular hypertrophy and diastolic heart failure.
Circulation. Heart failure 2011;4(3):246-56.
2011: Daryl L Reust; William T Rivers; Robert E Stroud; James H Abernathy; Jennifer A Dixon; Kevin Groves; Karen Madden; Richard A McKinney; Rupak Mukherjee; Risha K Patel; Milind Rajopadhye; Scott T Reeves; Francis G Spinale
Continuous localized monitoring of plasmin activity identifies differential and regional effects of the serine protease inhibitor aprotinin: relevance to antifibrinolytic therapy.
Journal of cardiovascular pharmacology 2011;57(4):400-6.
2011: Alessandro Giardini; Jeremy M Ringewald; Robert E Stroud; Geoffrey A Forbus; Scott M Bradley; Wendy Chung; Francis G Spinale
Determinants of extracellular matrix remodelling are differentially expressed in paediatric and adult dilated cardiomyopathy.
European journal of heart failure 2011;13(3):271-7.
2011: Alessandro Giardini; Jeremy M Ringewald; Robert E Stroud; Nadia Roessler; Nidhi Kumar; Scott T Reeves; Francis G Spinale
Plasma profiling determinants of matrix homeostasis in paediatric dilated cardiomyopathy.
Cardiology in the young 2011;21(1):52-61.
2010: Jennifer A Dixon; William F Gaillard; William T Rivers; Christine N Koval; Robert E Stroud; Rupak Mukherjee; Francis G Spinale
Heterogeneity in MT1-MMP activity with ischemia-reperfusion and previous myocardial infarction: relation to regional myocardial function.
American journal of physiology. Heart and circulatory physiology 2010;299(6):H1947-58.
2010: Tim C McQuinn; Rachael L Deardorff; Rupak Mukherjee; Anna Greta B Taylor; Eric M Graham; Andrew M Atz; Geoffrey A Forbus; Stacia M DeSantis; Jennifer B Young; Robert E Stroud; Fred A Crawford; Scott M Bradley; Scott T Reeves; Francis G Spinale
Circulating matrix metalloproteinase levels after ventricular septal defect repair in infants.
The Journal of thoracic and cardiovascular surgery 2010;140(6):1257-65.
2010: Francis G Spinale; Rupak Mukherjee; Juozas A Zavadzkas; Christine N Koval; Shenikqua Bouges; Robert E Stroud; Lawrence W Dobrucki; Albert J Sinusas
Cardiac restricted overexpression of membrane type-1 matrix metalloproteinase causes adverse myocardial remodeling following myocardial infarction.
The Journal of biological chemistry 2010;285(39):30316-27.
2010: Jeffrey A Jones; Juozas A Zavadzkas; Eileen I Chang; Nina Sheats; Christine Koval; Robert E Stroud; Francis G Spinale; John S Ikonomidis
Cellular phenotype transformation occurs during thoracic aortic aneurysm development.
The Journal of thoracic and cardiovascular surgery 2010;140(3):653-9.
2010: Rupak Mukherjee; William T Rivers; Jean Marie Ruddy; Robert G Matthews; Christine N Koval; Rebecca A Plyler; Eileen I Chang; Risha K Patel; Christine B Kern; Robert E Stroud; Francis G Spinale
Long-term localized high-frequency electric stimulation within the myocardial infarct: effects on matrix metalloproteinases and regional remodeling.
Circulation 2010;122(1):20-32.
2010: Rupak Mukherjee; Juozas A Zavadzkas; William T Rivers; Julie E McLean; Eileen I Chang; Shenikqua Bouges; Robert G Matthews; Christine N Koval; Robert E Stroud; Francis G Spinale
Short-term disruption in regional left ventricular electrical conduction patterns increases interstitial matrix metalloproteinase activity.
American journal of physiology. Heart and circulatory physiology 2010;299(1):H217-24.
2010: Jeffrey A Jones; Jean Marie Ruddy; Shenikqua Bouges; Juozas A Zavadzkas; Theresa A Brinsa; Robert E Stroud; Rupak Mukherjee; Francis G Spinale; John S Ikonomidis
Alterations in membrane type-1 matrix metalloproteinase abundance after the induction of thoracic aortic aneurysm in a murine model.
American journal of physiology. Heart and circulatory physiology 2010;299(1):H114-24.
2010: Alessandro Giardini; Tim C McQuinn; Rupak Mukherjee; Rachael L Deardorff; Jerry E Squires; Robert E Stroud; Fred A Crawford; Scott M Bradley; Scott T Reeves; Francis G Spinale
Effects of aprotinin or tranexamic acid on proteolytic/cytokine profiles in infants after cardiac surgery.
The Annals of thoracic surgery 2010;89(6):1843-52; discussion 1852.
2010: Daryl L Reust; Scott T Reeves; James H Abernathy; Jennifer A Dixon; William F Gaillard; Rupak Mukherjee; Christine N Koval; Robert E Stroud; Francis G Spinale
Interstitial plasmin activity with epsilon aminocaproic acid: temporal and regional heterogeneity.
The Annals of thoracic surgery 2010;89(5):1538-45.
2010: Sonam A Shah; Francis G Spinale; John S Ikonomidis; Robert E Stroud; Eileen I Chang; Carolyn E Reed
Differential matrix metalloproteinase levels in adenocarcinoma and squamous cell carcinoma of the lung.
The Journal of thoracic and cardiovascular surgery 2010;139(4):984-90; discussion 990.
2010: Daryl L Reust; Scott T Reeves; James H Abernathy; Jennifer A Dixon; William F Gaillard; Rupak Mukherjee; Christine N Koval; Robert E Stroud; Francis G Spinale
Temporally and regionally disparate differences in plasmin activity by tranexamic acid.
Anesthesia and analgesia 2010;110(3):694-701.
2009: Jean Marie Ruddy; Jeffrey Jones; Robert E Stroud; Rupak Mukherjee; Francis G Spinale; John S Ikonomidis
Differential effects of mechanical and biological stimuli on matrix metalloproteinase promoter activation in the thoracic aorta.
Circulation 2009;120(11 Suppl):S262-8.
2009: Francis G Spinale; G Patricia Escobar; Rupak Mukherjee; Juozas A Zavadzkas; Stuart M Saunders; Laura B Jeffords; Allyson M Leone; Christy Beck; Shenikqua Bouges; Robert E Stroud
Cardiac-restricted overexpression of membrane type-1 matrix metalloproteinase in mice: effects on myocardial remodeling with aging.
Circulation. Heart failure 2009;2(4):351-60.
2009: Matt Mcevoy; Michel J Sabbagh; Anna Greta Taylor; Juozas A Zavadzkas; Christine N Koval; Robert E Stroud; Rachael L Ford; Julie E McLean; Scott T Reeves; Rupak Mukherjee; Francis G Spinale
Aprotinin modifies left ventricular contractility and cytokine release after ischemia-reperfusion in a dose-dependent manner in a murine model.
Anesthesia and analgesia 2009;108(2):399-406.
2008: Michel J Sabbagh; J Michael Looper; Juozas A Zavadzkas; Robert E Stroud; Rachael L Ford; William T Rivers; Christine N Koval; Matt Mcevoy; Scott T Reeves; Francis G Spinale
Aprotinin exacerbates left ventricular dysfunction after ischemia/reperfusion in mice lacking tumor necrosis factor receptor I.
Journal of cardiovascular pharmacology 2008;52(4):355-62.
2008: Rupak Mukherjee; Juozas A Zavadzkas; Stuart M Saunders; Julie E McLean; Laura B Jeffords; Christy Beck; Robert E Stroud; Allyson M Leone; Christine N Koval; William T Rivers; Shubhayu Basu; Alexander Sheehy; Gene Michal; Francis G Spinale
Targeted myocardial microinjections of a biocomposite material reduces infarct expansion in pigs.
The Annals of thoracic surgery 2008;86(4):1268-76.
2008: Juozas A Zavadzkas; Rebecca A Plyler; Shenikqua Bouges; Christine N Koval; William T Rivers; Christy U Beck; Eileen I Chang; Robert E Stroud; Rupak Mukherjee; Francis G Spinale
Cardiac-restricted overexpression of extracellular matrix metalloproteinase inducer causes myocardial remodeling and dysfunction in aging mice.
American journal of physiology. Heart and circulatory physiology 2008;295(4):H1394-402.
2008: Francis G Spinale; Christine N Koval; Anne M Deschamps; Robert E Stroud; John S Ikonomidis
Dynamic changes in matrix metalloprotienase activity within the human myocardial interstitium during myocardial arrest and reperfusion.
Circulation 2008;118(14 Suppl):S16-23.
2008: Matt Mcevoy; Anna-Greta Taylor; Juozas A Zavadzkas; Ira M Mains; Rachael L Ford; Robert E Stroud; Laura B Jeffords; Christy U Beck; Scott T Reeves; Francis G Spinale
Aprotinin exerts differential and dose-dependent effects on myocardial contractility, oxidative stress, and cytokine release after ischemia-reperfusion.
The Annals of thoracic surgery 2008;86(2):568-75.
2008: B Hugh Dorman; Robert E Stroud; Michael M Wyckoff; James L Zellner; Don Botta; Amy H Leonardi; John S Ikonomidis; Francis G Spinale
Differential effects of epsilon-aminocaproic acid and aprotinin on matrix metalloproteinase release in patients following cardiopulmonary bypass.
Journal of cardiovascular pharmacology 2008;51(4):418-23.
2008: Anne M Deschamps; Juozas Zavadzkas; Rebecca L Murphy; Christine N Koval; Julie E McLean; Laura Jeffords; Stuart M Saunders; Nina J Sheats; Robert E Stroud; Francis G Spinale
Interruption of endothelin signaling modifies membrane type 1 matrix metalloproteinase activity during ischemia and reperfusion.
American journal of physiology. Heart and circulatory physiology 2008;294(2):H875-83.
2007: Laura S Spruill; Abigail S Lowry; Robert E Stroud; Christina E Squires; I Matthew Mains; English C Flack; Christy Beck; John S Ikonomidis; Arthur J Crumbley; Paul J McDermott; Francis G Spinale
Membrane-type-1 matrix metalloproteinase transcription and translation in myocardial fibroblasts from patients with normal left ventricular function and from patients with cardiomyopathy.
American journal of physiology. Cell physiology 2007;293(4):C1362-73.
2007: Jeffrey Jones; Robert E Stroud; Brooke S Kaplan; Allyson M Leone; Joseph E Bavaria; Joseph H Gorman; Robert Gorman; John S Ikonomidis
Differential protein kinase C isoform abundance in ascending aortic aneurysms from patients with bicuspid versus tricuspid aortic valves.
Circulation 2007;116(11 Suppl):I144-9.
2007: D Dirk Bonnema; Carson S Webb; Weems R Pennington; Robert E Stroud; Amy E Leonardi; Leslie L Clark; Catherine D McClure; Laura Finklea; Francis G Spinale; Michael R Zile
Effects of age on plasma matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs).
Journal of cardiac failure 2007;13(7):530-40.
2007: John S Ikonomidis; Ebony J Hilton; Kim J. Payne; April Harrell; Laura Finklea; Leslie Clark; Scott T Reeves; Robert E Stroud; Amy H Leonardi; Fred A Crawford; Francis G Spinale
Selective endothelin-A receptor inhibition after cardiac surgery: a safety and feasibility study.
The Annals of thoracic surgery 2007;83(6):2153-60; discussion 2161.
2007: John S Ikonomidis; Jeffrey Jones; John R Barbour; Robert E Stroud; Leslie L Clark; Brooke S Kaplan; Ahmad Zeeshan; Joseph E Bavaria; Joseph H Gorman; Francis G Spinale; Robert Gorman
Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with bicuspid or tricuspid aortic valves.
The Journal of thoracic and cardiovascular surgery 2007;133(4):1028-36.
2006: Rupak Mukherjee; Joseph T Mingoia; James A Bruce; Jeffrey S Austin; Robert E Stroud; G Patricia Escobar; David M McClister; Claire M Allen; Maria A Alfonso-Jaume; M Elizabeth Fini; David H Lovett; Francis G Spinale
Selective spatiotemporal induction of matrix metalloproteinase-2 and matrix metalloproteinase-9 transcription after myocardial infarction.
American journal of physiology. Heart and circulatory physiology 2006;291(5):H2216-28.
2006: John R Barbour; Robert E Stroud; Abigail S Lowry; Leslie L Clark; Allyson M Leone; Jeffrey Jones; Francis G Spinale; John S Ikonomidis
Temporal disparity in the induction of matrix metalloproteinases and tissue inhibitors of metalloproteinases after thoracic aortic aneurysm formation.
The Journal of thoracic and cardiovascular surgery 2006;132(4):788-95.
2006: Carson S Webb; D Dirk Bonnema; S Hinan Ahmed; Amy H Leonardi; Catherine D McClure; Leslie L Clark; Robert E Stroud; William C Corn; Laura Finklea; Michael R Zile; Francis G Spinale
Specific temporal profile of matrix metalloproteinase release occurs in patients after myocardial infarction: relation to left ventricular remodeling.
Circulation 2006;114(10):1020-7.
2006: Francis G Spinale; G Patricia Escobar; Jennifer W Hendrick; Leslie L Clark; Sarah S Camens; Joseph P Mingoia; Christina G Squires; Robert E Stroud; John S Ikonomidis
Chronic matrix metalloproteinase inhibition following myocardial infarction in mice: differential effects on short and long-term survival.
The Journal of pharmacology and experimental therapeutics 2006;318(3):966-73.
2006: Kimberly A Apple; Julie E McLean; Christina E Squires; Brooke Schaeffer; Jeffrey A Sample; Rebecca L Murphy; Anne M Deschamps; Amy H Leonardi; Claire M Allen; Jennifer W Hendrick; Robert E Stroud; Rupak Mukherjee; Francis G Spinale
Differential effects of protein kinase C isoform activation in endothelin-mediated myocyte contractile dysfunction with cardioplegic arrest and reperfusion.
The Annals of thoracic surgery 2006;82(2):664-71.
2006: John S Ikonomidis; Jeffrey Jones; John R Barbour; Robert E Stroud; Leslie L Clark; Brooke S Kaplan; Ahmad Zeeshan; Joseph E Bavaria; Joseph H Gorman; Francis G Spinale; Robert Gorman
Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with Marfan syndrome.
Circulation 2006;114(1 Suppl):I365-70.
2006: Rupak Mukherjee; Kimberly A Apple; Christina E Squires; Brooke S Kaplan; Julie E McLean; Stuart M Saunders; Robert E Stroud; Francis G Spinale
Protein kinase C isoform activation and endothelin-1 mediated defects in myocyte contractility after cardioplegic arrest and reperfusion.
Circulation 2006;114(1 Suppl):I308-13.
2006: English C Flack; Merry Lindsey; Christina E Squires; Brooke S Kaplan; Robert E Stroud; Leslie L Clark; Patricia G Escobar; William M Yarbrough; Francis G Spinale
Alterations in cultured myocardial fibroblast function following the development of left ventricular failure.
Journal of molecular and cellular cardiology 2006;40(4):474-83.
2006: Rupak Mukherjee; Amanda R Herron; Abigail S Lowry; Robert E Stroud; Martha R Stroud; John Marcus Wharton; John S Ikonomidis; Arthur J Crumbley; Francis G Spinale; Michael R Gold
Selective induction of matrix metalloproteinases and tissue inhibitor of metalloproteinases in atrial and ventricular myocardium in patients with atrial fibrillation.
The American journal of cardiology 2006;97(4):532-7.
2006: Kimberly A Apple; William M Yarbrough; Rupak Mukherjee; Anne M Deschamps; Patricia G Escobar; Joseph T Mingoia; Jeffrey A Sample; Jennifer W Hendrick; Kathryn B Dowdy; Julie E McLean; Robert E Stroud; Timothy P O'Neill; Francis G Spinale
Selective targeting of matrix metalloproteinase inhibition in post-infarction myocardial remodeling.
Journal of cardiovascular pharmacology 2006;47(2):228-35.
2005: John S Ikonomidis; John R Barbour; Zainab Amani; Robert E Stroud; Amanda R Herron; David M McClister; Sarah E Camens; Merry Lindsey; Rupak Mukherjee; Francis G Spinale
Effects of deletion of the matrix metalloproteinase 9 gene on development of murine thoracic aortic aneurysms.
Circulation 2005;112(9 Suppl):I242-8.
2005: Aaron S Blom; Rupak Mukherjee; James J Pilla; Abigail S Lowry; William M Yarbrough; Joseph T Mingoia; Jennifer W Hendrick; Robert E Stroud; Julie E McLean; John Affuso; Robert Gorman; Joseph H Gorman; Michael A Acker; Francis G Spinale
Cardiac support device modifies left ventricular geometry and myocardial structure after myocardial infarction.
Circulation 2005;112(9):1274-83.
2005: Anne M Deschamps; Kimberly A Apple; Amy H Leonardi; Julie E McLean; William M Yarbrough; Robert E Stroud; Leslie L Clark; Jeffrey A Sample; Francis G Spinale
Myocardial interstitial matrix metalloproteinase activity is altered by mechanical changes in LV load: interaction with the angiotensin type 1 receptor.
Circulation research 2005;96(10):1110-8.
2005: Robert E Stroud; Anne M Deschamps; Abigail S Lowry; Amy E Hardin; Rupak Mukherjee; Merry Lindsey; Sammanda Ramamoorthy; Michael R Zile; William H Spencer; Francis G Spinale
Plasma monitoring of the myocardial specific tissue inhibitor of metalloproteinase-4 after alcohol septal ablation in hypertrophic obstructive cardiomyopathy.
Journal of cardiac failure 2005;11(2):124-30.
2005: John S Ikonomidis; Jennifer W Hendrick; Andrea M Parkhurst; Amanda R Herron; Patricia G Escobar; Kathryn B Dowdy; Robert E Stroud; Elizabeth Hapke; Michael R Zile; Francis G Spinale
Accelerated LV remodeling after myocardial infarction in TIMP-1-deficient mice: effects of exogenous MMP inhibition.
American journal of physiology. Heart and circulatory physiology 2005;288(1):H149-58.
2004: William M Yarbrough; Rupak Mukherjee; Christina E Squires; Emily S Reese; Jennifer S Leiser; Robert E Stroud; Jeffrey A Sample; Jennifer W Hendrick; Joseph T Mingoia; Julie E McLean; Amy E Hardin; Kathryn B Dowdy; Francis G Spinale
Caspase inhibition attenuates contractile dysfunction following cardioplegic arrest and rewarming in the setting of left ventricular failure.
Journal of cardiovascular pharmacology 2004;44(6):645-50.
2004: Jessica R Garner; Robert E Stroud; Laura Finklea; John S Ikonomidis; B Hugh Dorman; Francis G Spinale
The effects of leukocyte reduction on matrix metalloproteinase release in cardiopulmonary bypass.
The Journal of extra-corporeal technology 2004;36(2):185-90.
2004: Rupak Mukherjee; William M Yarbrough; Emily S Reese; Jennifer S Leiser; Jeffrey A Sample; Joseph T Mingoia; Amy E Hardin; Robert E Stroud; Julie E McLean; Jennifer W Hendrick; Francis G Spinale
Myocyte contractility with caspase inhibition and simulated hyperkalemic cardioplegic arrest.
The Annals of thoracic surgery 2004;77(5):1684-9; discussion 1689-90.
2003: William M Yarbrough; Rupak Mukherjee; G Patricia Escobar; Joseph T Mingoia; Jeffrey A Sample; Jennifer W Hendrick; Kathryn B Dowdy; Julie E McLean; Robert E Stroud; Francis G Spinale
Direct inhibition of the sodium/hydrogen exchanger after prolonged regional ischemia improves contractility on reperfusion independent of myocardial viability.
The Journal of thoracic and cardiovascular surgery 2003;126(5):1489-97.
2003: R English Chapman; Amelia A Scott; Anne M Deschamps; Abigail S Lowry; Robert E Stroud; John S Ikonomidis; Francis G Spinale
Matrix metalloproteinase abundance in human myocardial fibroblasts: effects of sustained pharmacologic matrix metalloproteinase inhibition.
Journal of molecular and cellular cardiology 2003;35(5):539-48.