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Robert Stroud

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X Ray Crystallography

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Bjørn P Pedersen; Aaron J Risenmay; Zygy Roe-Zurz; Andrej Sali; Avner Schlessinger; Massimiliano Bonomi; Bryant H Chau; William Harries; Atul K Johri; Hemant Kumar; Andrew B Waight; Robert M Stroud
Crystal structure of a eukaryotic phosphate transporter.
Ursula Pieper; Douglas C Rees; Burkhard Rost; Avner Schlessinger; Raymond C Stevens; David L Stokes; Michael H B Stowell; Robert M Stroud; Michael C Wiener; Geoffrey A Chang; James J Chou; Mark E Dumont; Brian G Fox; Petra Fromme; Wayne A Hendrickson; Edda Kloppmann; Michael G Malkowski; Andrej Sali
Coordinating the impact of structural genomics on the human α-helical transmembrane proteome.
Louis E Metzger; Christian R H Raetz; Janet S Finer-Moore; John K Lee; Robert M Stroud
LpxI structures reveal how a lipid A precursor is synthesized.

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All Publications

2013: Bjørn P Pedersen; Aaron J Risenmay; Zygy Roe-Zurz; Andrej Sali; Avner Schlessinger; Massimiliano Bonomi; Bryant H Chau; William Harries; Atul K Johri; Hemant Kumar; Andrew B Waight; Robert M Stroud
Crystal structure of a eukaryotic phosphate transporter.
Nature 2013;496(7446):533-6.
2013: Ursula Pieper; Douglas C Rees; Burkhard Rost; Avner Schlessinger; Raymond C Stevens; David L Stokes; Michael H B Stowell; Robert M Stroud; Michael C Wiener; Geoffrey A Chang; James J Chou; Mark E Dumont; Brian G Fox; Petra Fromme; Wayne A Hendrickson; Edda Kloppmann; Michael G Malkowski; Andrej Sali
Coordinating the impact of structural genomics on the human α-helical transmembrane proteome.
Nature structural & molecular biology 2013;20(2):135-8.
2012: Louis E Metzger; Christian R H Raetz; Janet S Finer-Moore; John K Lee; Robert M Stroud
LpxI structures reveal how a lipid A precursor is synthesized.
Nature structural & molecular biology 2012;19(11):1132-8.
2012: Michel Varrin-Doyer; Bruce A C Cree; Patricia A Nelson; Ulf Schulze Topphoff; Collin M Spencer; Robert M Stroud; Scott S Zamvil
Aquaporin 4-specific T cells in neuromyelitis optica exhibit a Th17 bias and recognize Clostridium ABC transporter.
Annals of neurology 2012;72(1):53-64.
2012: Shenping Wu; Yadong Yu; Akram Alian; Agustin Avila-Sakar; David S Booth; Javier Chaparro-Riggers; Charles S Craik; Robert H Edwards; Charles H Greenberg; Sarah L Griner; Narinobu Juge; JungMin Kim; Xueming Li; Maofu Liao; Claudia M Mergel; Andrea Rossi; Pavel Strop; Robert M Stroud; Robert Tampé; Yifan Cheng
Fabs enable single particle cryoEM studies of small proteins.
Structure (London, England : 1993) 2012;20(4):582-92.
2012: Sarika Chaudhary; Franz Gruswitz; John E Pak; Vinay Sharma; Robert M Stroud
Overexpressing human membrane proteins in stably transfected and clonal human embryonic kidney 293S cells.
Nature protocols 2012;7(3):453-66.
2011: Jungmin Kim; Robert M Stroud; Charles S Craik
Rapid identification of recombinant Fabs that bind to membrane proteins.
Methods (San Diego, Calif.) 2011;55(4):303-9.
2011: Sarika Chaudhary; Raissa G Green; Samantha M M Ngaw; John E Pak; Bjørn P Pedersen; Vinay Sharma; Lois J Bang; Liye B Zhang; Robert M Stroud
Efficient expression screening of human membrane proteins in transiently transfected Human Embryonic Kidney 293S cells.
Methods (San Diego, Calif.) 2011;55(4):273-80.
2011: Oren S Rosenberg; Robert M Stroud; Michael Tempesta; Cole Dovey; Janet S Finer-Moore; Rebecca A Robbins; Jeffery S Cox
EspR, a key regulator of Mycobacterium tuberculosis virulence, adopts a unique dimeric structure among helix-turn-helix proteins.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(33):13450-5.
2011: Robert M Stroud; Gerhard F X Schertler
Membranes.
Current opinion in structural biology 2011;21(4):495-6.
2011: Alexei V Korennykh; Andrei A Korostelev; Kevan M Shokat; Robert M Stroud; Pascal F Egea; Janet Finer-Moore; Chao Zhang; Peter Walter
Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1.
BMC biology 2011;9():48.
2011: Alexei V Korennykh; Andrei A Korostelev; Kevan M Shokat; Robert M Stroud; Pascal F Egea; Janet Finer-Moore; Chao Zhang; Peter Walter
Structural and functional basis for RNA cleavage by Ire1.
BMC biology 2011;9():47.
2010: David F Savage; Joseph D O'Connell; Larry J W Miercke; Janet S Finer-Moore; Robert M Stroud
Structural context shapes the aquaporin selectivity filter.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(40):17164-9.
2010: Franz Gruswitz; Sarika Chaudhary; Joseph D Ho; Avner Schlessinger; Bobak Pezeshki; Chi-Min Ho; Andrej Sali; Connie M Westhoff; Robert M Stroud
Function of human Rh based on structure of RhCG at 2.1 A.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(21):9638-43.
2010: Avner Schlessinger; Pär Matsson; James E Shima; Ursula Pieper; Sook Wah Yee; Libusha Kelly; Leonard Apeltsin; Robert M Stroud; Thomas E Ferrin; Kathleen M Giacomini; Andrej Sali
Comparison of human solute carriers.
Protein science : a publication of the Protein Society 2010;19(3):412-28.
2010: Patricia A Nelson; Mojgan Khodadoust; Thomas Prodhomme; Collin Spencer; Juan Carlos Patarroyo; Michel Varrin-Doyer; Joseph D Ho; Robert M Stroud; Scott S Zamvil
Immunodominant T cell determinants of aquaporin-4, the autoantigen associated with neuromyelitis optica.
PloS one 2010;5(11):e15050.
2010: Franklin A Hays; Zygy Roe-Zurz; Robert M Stroud
Overexpression and purification of integral membrane proteins in yeast.
Methods in enzymology 2010;470():695-707.
2009: Libusha Kelly; Ursula Pieper; Narayanan Eswar; Franklin A Hays; Min Li; Zygy Roe-Zurz; Deanna L Kroetz; Kathleen M Giacomini; Robert M Stroud; Andrej Sali
A survey of integral alpha-helical membrane proteins.
Journal of structural and functional genomics 2009;10(4):269-80.
2009: Akram Alian; Sarah L Griner; Vicki Chiang; Manuel Tsiang; Gregg Jones; Gabriel Birkus; Romas Geleziunas; Andrew D Leavitt; Robert M Stroud
Catalytically-active complex of HIV-1 integrase with a viral DNA substrate binds anti-integrase drugs.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(20):8192-7.
2009: Akram Alian; Andrew DeGiovanni; Sarah L Griner; Janet S Finer-Moore; Robert M Stroud
Crystal structure of an RluF-RNA complex: a base-pair rearrangement is the key to selectivity of RluF for U2604 of the ribosome.
Journal of molecular biology 2009;388(4):785-800.
2009: Joseph D Ho; Ronald Yeh; Andrew Sandstrom; Ilya Chorny; William Harries; Rebecca A Robbins; Larry J W Miercke; Robert M Stroud
Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(18):7437-42.
2009: Franklin A Hays; Zygy Roe-Zurz; Min Li; Libusha Kelly; Franz Gruswitz; Andrej Sali; Robert M Stroud
Ratiocinative screen of eukaryotic integral membrane protein expression and solubilization for structure determination.
Journal of structural and functional genomics 2009;10(1):9-16.
2009: Alexei V Korennykh; Pascal F Egea; Andrei A Korostelev; Janet Finer-Moore; Chao Zhang; Kevan M Shokat; Robert M Stroud; Peter Walter
The unfolded protein response signals through high-order assembly of Ire1.
Nature 2009;457(7230):687-93.
2009: Min Li; Franklin A Hays; Zygy Roe-Zurz; Linda Vuong; Libusha Kelly; Chi-Min Ho; Renée M Robbins; Ursula Pieper; Joseph D O'Connell; Larry J W Miercke; Kathleen M Giacomini; Andrej Sali; Robert M Stroud
Selecting optimum eukaryotic integral membrane proteins for structure determination by rapid expression and solubilization screening.
Journal of molecular biology 2009;385(3):820-30.
2009: Zachary E R Newby; Joseph D O'Connell; Franz Gruswitz; Franklin A Hays; William E C Harries; Ian M Harwood; Joseph D Ho; John K Lee; David F Savage; Larry J W Miercke; Robert M Stroud
A general protocol for the crystallization of membrane proteins for X-ray structural investigation.
Nature protocols 2009;4(5):619-37.
2008: Robert M Stroud
Michael A. Raftery (1936-2007)--the first enzyme mechanism, sequential cooperativity, and the nicotinic acetylcholine receptor defined.
Protein science : a publication of the Protein Society 2008;17(10):1864-6.
2008: John K Lee; Grigory I Belogrudov; Robert M Stroud
Crystal structure of bovine mitochondrial factor B at 0.96-A resolution.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(36):13379-84.
2008: Zachary E R Newby; Joseph O'Connell; Yaneth Robles-Colmenares; Shahram Khademi; Larry J W Miercke; Robert M Stroud
Crystal structure of the aquaglyceroporin PfAQP from the malarial parasite Plasmodium falciparum.
Nature structural & molecular biology 2008;15(6):619-25.
2008: Akram Alian; Tom T Lee; Sarah L Griner; Robert M Stroud; Janet S Finer-Moore
Structure of a TrmA-RNA complex: A consensus RNA fold contributes to substrate selectivity and catalysis in m5U methyltransferases.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(19):6876-81.
2008: Zhihua Du; John K Lee; Richard Tjhen; Robert M Stroud; Tom L James
Structural and biochemical insights into the dicing mechanism of mouse Dicer: a conserved lysine is critical for dsRNA cleavage.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(7):2391-6.
2008: Pascal F Egea; Hiro Tsuruta; Gladys P de Leon; Johanna Napetschnig; Peter Walter; Robert M Stroud
Structures of the signal recognition particle receptor from the archaeon Pyrococcus furiosus: implications for the targeting step at the membrane.
PloS one 2008;3(11):e3619.
2008: Pascal F Egea; Johanna Napetschnig; Peter Walter; Robert M Stroud
Structures of SRP54 and SRP19, the two proteins that organize the ribonucleic core of the signal recognition particle from Pyrococcus furiosus.
PloS one 2008;3(10):e3528.
2007: Karen Menuz; Robert M Stroud; Roger A Nicoll; Franklin A Hays
TARP auxiliary subunits switch AMPA receptor antagonists into partial agonists.
Science (New York, N.Y.) 2007;318(5851):815-7.
2007: Zhihua Du; John K Lee; Sebastian Fenn; Richard Tjhen; Robert M Stroud; Tom L James
X-ray crystallographic and NMR studies of protein-protein and protein-nucleic acid interactions involving the KH domains from human poly(C)-binding protein-2.
RNA (New York, N.Y.) 2007;13(7):1043-51.
2007: David F Savage; Robert M Stroud
Structural basis of aquaporin inhibition by mercury.
Journal of molecular biology 2007;368(3):607-17.
2007: David F Savage; Corey L Anderson; Yaneth Robles-Colmenares; Zachary E Newby; Robert M Stroud
Cell-free complements in vivo expression of the E. coli membrane proteome.
Protein science : a publication of the Protein Society 2007;16(5):966-76.
2007: Sun Hur; Robert M Stroud
How U38, 39, and 40 of many tRNAs become the targets for pseudouridylation by TruA.
Molecular cell 2007;26(2):189-203.
2007: Hu Pan; Joseph D Ho; Robert M Stroud; Janet S Finer-Moore
The crystal structure of E. coli rRNA pseudouridine synthase RluE.
Journal of molecular biology 2007;367(5):1459-70.
2007: Robert M Stroud
Transmembrane transporters: an open and closed case.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(5):1445-6.
2007: Franz Gruswitz; Joseph O'Connell; Robert M Stroud
Inhibitory complex of the transmembrane ammonia channel, AmtB, and the cytosolic regulatory protein, GlnK, at 1.96 A.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(1):42-7.
2007: Christopher Reyes; Earl Rutenber; Peter Walter; Robert M Stroud
X-ray structures of the signal recognition particle receptor reveal targeting cycle intermediates.
PloS one 2007;2(7):e607.
2007: Sebastian Fenn; Zhihua Du; John K Lee; Richard Tjhen; Robert M Stroud; Tom L James
Crystal structure of the third KH domain of human poly(C)-binding protein-2 in complex with a C-rich strand of human telomeric DNA at 1.6 A resolution.
Nucleic acids research 2007;35(8):2651-60.
2006: Sun Hur; Robert M Stroud; Janet S Finer-Moore
Substrate recognition by RNA 5-methyluridine methyltransferases and pseudouridine synthases: a structural perspective.
The Journal of biological chemistry 2006;281(51):38969-73.
2006: Shahram Khademi; Robert M Stroud
The Amt/MEP/Rh family: structure of AmtB and the mechanism of ammonia gas conduction.
Physiology (Bethesda, Md.) 2006;21():419-29.
2006: Xin He; Akram Alian; Robert M Stroud; Paul R. Ortiz de Montellano
Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis.
Journal of medicinal chemistry 2006;49(21):6308-23.
2006: Zachary Newby; Tom T Lee; Richard J Morse; Yaoquan Liu; Lu Liu; Prasanna Venkatraman; Daniel V Santi; Janet S Finer-Moore; Robert M Stroud
The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261.
Biochemistry 2006;45(24):7415-28.
2006: Adrian T Keatinge-Clay; Robert M Stroud
The structure of a ketoreductase determines the organization of the beta-carbon processing enzymes of modular polyketide synthases.
Structure (London, England : 1993) 2006;14(4):737-48.
2005: Joel J Credle; Janet S Finer-Moore; Feroz R Papa; Robert M Stroud; Peter Walter
On the mechanism of sensing unfolded protein in the endoplasmic reticulum.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(52):18773-84.
2005: John K Lee; David Kozono; Jonathan Remis; Yoshichika Kitagawa; Peter Agre; Robert M Stroud
Structural basis for conductance by the archaeal aquaporin AqpM at 1.68 A.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(52):18932-7.
2005: Zhihua Du; John K Lee; Richard Tjhen; Shang Li; Hu Pan; Robert M Stroud; Tom L James
Crystal structure of the first KH domain of human poly(C)-binding protein-2 in complex with a C-rich strand of human telomeric DNA at 1.7 A.
The Journal of biological chemistry 2005;280(46):38823-30.
2005: Janet S Finer-Moore; Amy C Anderson; Robert H O'Neil; M Paola Costi; Stefania Ferrari; Jolanta Krucinski; Robert M Stroud
The structure of Cryptococcus neoformans thymidylate synthase suggests strategies for using target dynamics for species-specific inhibition.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 10):1320-34.
2005: Pascal F Egea; Robert M Stroud; Peter Walter
Targeting proteins to membranes: structure of the signal recognition particle.
Current opinion in structural biology 2005;15(2):213-20.
2005: Tom T Lee; Sanjay Agarwalla; Robert M Stroud
A unique RNA Fold in the RumA-RNA-cofactor ternary complex contributes to substrate selectivity and enzymatic function.
Cell 2005;120(5):599-611.
2005: Sherry L. LaPorte; Charles M Forsyth; Brian C Cunningham; Larry J W Miercke; David Akhavan; Robert M Stroud
De novo design of an IL-4 antagonist and its structure at 1.9 A.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(6):1889-94.
2004: Feixia Chu; Shu-ou Shan; Demetri T Moustakas; Frank Alber; Pascal F Egea; Robert M Stroud; Peter Walter; Al L Burlingame
Unraveling the interface of signal recognition particle and its receptor by using chemical cross-linking and tandem mass spectrometry.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(47):16454-9.
2004: Shu-ou Shan; Robert M Stroud; Peter Walter
Mechanism of association and reciprocal activation of two GTPases.
PLoS biology 2004;2(10):e320.
2004: William Harries; David Akhavan; Larry J W Miercke; Shahram Khademi; Robert M Stroud
The channel architecture of aquaporin 0 at a 2.2-A resolution.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(39):14045-50.
2004: Shahram Khademi; Joseph O'Connell; Jonathan Remis; Yaneth Robles-Colmenares; Larry J W Miercke; Robert M Stroud
Mechanism of ammonia transport by Amt/MEP/Rh: structure of AmtB at 1.35 A.
Science (New York, N.Y.) 2004;305(5690):1587-94.
2004: Adrian T Keatinge-Clay; David A Maltby; Katalin F Medzihradszky; Chaitan Khosla; Robert M Stroud
An antibiotic factory caught in action.
Nature structural & molecular biology 2004;11(9):888-93.
2004: Sanjay Agarwalla; Robert M Stroud; Betty J Gaffney
Redox reactions of the iron-sulfur cluster in a ribosomal RNA methyltransferase, RumA: optical and EPR studies.
The Journal of biological chemistry 2004;279(33):34123-9.
2004: Robert M Stroud; James A Wells
Mechanistic diversity of cytokine receptor signaling across cell membranes.
Science's STKE : signal transduction knowledge environment 2004;2004(231):re7.
2004: Tom T Lee; Sanjay Agarwalla; Robert M Stroud
Crystal structure of RumA, an iron-sulfur cluster containing E. coli ribosomal RNA 5-methyluridine methyltransferase.
Structure (London, England : 1993) 2004;12(3):397-407.
2004: Pascal F Egea; Shu-ou Shan; Johanna Napetschnig; David F Savage; Peter Walter; Robert M Stroud
Substrate twinning activates the signal recognition particle and its receptor.
Nature 2004;427(6971):215-21.
2004: John K Lee; Shahram Khademi; William Harries; David Savage; Larry J W Miercke; Robert M Stroud
Water and glycerol permeation through the glycerol channel GlpF and the aquaporin family.
Journal of synchrotron radiation 2004;11(Pt 1):86-8.
2003: Robert H O'Neil; Ryan H Lilien; Bruce Randall Donald; Robert M Stroud; Amy C Anderson
Phylogenetic classification of protozoa based on the structure of the linker domain in the bifunctional enzyme, dihydrofolate reductase-thymidylate synthase.
The Journal of biological chemistry 2003;278(52):52980-7.
2003: David F Savage; Pascal F Egea; Yaneth Robles-Colmenares; Joseph D O'Connell; Robert M Stroud
Architecture and selectivity in aquaporins: 2.5 a X-ray structure of aquaporin Z.
PLoS biology 2003;1(3):E72.
2003: Paul G Foster; Christa R Nunes; Patricia Greene; Demetri Moustakas; Robert M Stroud
The first structure of an RNA m5C methyltransferase, Fmu, provides insight into catalytic mechanism and specific binding of RNA substrate.
Structure (London, England : 1993) 2003;11(12):1609-20.
2003: Kenji Watanabe; Chaitan Khosla; Robert M Stroud; Shiou-Chuan Tsai
Crystal structure of an Acyl-ACP dehydrogenase from the FK520 polyketide biosynthetic pathway: insights into extender unit biosynthesis.
Journal of molecular biology 2003;334(3):435-44.
2003: Robert M Stroud; David Savage; Larry J W Miercke; John K Lee; Shahram Khademi; William Harries
Selectivity and conductance among the glycerol and water conducting aquaporin family of channels.
FEBS letters 2003;555(1):79-84.
2003: Hu Pan; Sanjay Agarwalla; Demetri T Moustakas; Janet S Finer-Moore; Robert M Stroud
Structure of tRNA pseudouridine synthase TruB and its RNA complex: RNA recognition through a combination of rigid docking and induced fit.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(22):12648-53.
2003: Dolores Gonzalez-Pacanowska; Luis M Ruiz-Perez; María Angeles Carreras-Gómez; M Paola Costi; Robert M Stroud; Janet S Finer-Moore; Daniel V Santi
The structural roles of conserved Pro196, Pro197 and His199 in the mechanism of thymidylate synthase.
Protein engineering 2003;16(8):607-14.
2003: Robert M Stroud; Larry J W Miercke; Joseph O'Connell; Shahram Khademi; John K Lee; Jonathan Remis; William Harries; Yaneth Robles; David Akhavan
Glycerol facilitator GlpF and the associated aquaporin family of channels.
Current opinion in structural biology 2003;13(4):424-31.
2003: Joseph M Jez; Julian C-H Chen; Giulio Rastelli; Robert M Stroud; Daniel V Santi
Crystal structure and molecular modeling of 17-DMAG in complex with human Hsp90.
Chemistry & biology 2003;10(4):361-8.
2003: Keith K. Reiling; Jolanta Krucinski; Larry J W Miercke; Wilfred W Raymond; George H Caughey; Robert M Stroud
Structure of human pro-chymase: a model for the activating transition of granule-associated proteases.
Biochemistry 2003;42(9):2616-24.
2003: David L Birdsall; Janet S Finer-Moore; Robert M Stroud
The only active mutant of thymidylate synthase D169, a residue far from the site of methyl transfer, demonstrates the exquisite nature of enzyme specificity.
Protein engineering 2003;16(3):229-40.
2003: Adrian T Keatinge-Clay; Anang A Shelat; David F Savage; Shiou-Chuan Tsai; Larry J W Miercke; Joseph D O'Connell; Chaitan Khosla; Robert M Stroud
Catalysis, specificity, and ACP docking site of Streptomyces coelicolor malonyl-CoA:ACP transacylase.
Structure (London, England : 1993) 2003;11(2):147-54.
2003: Janet S Finer-Moore; Daniel V Santi; Robert M Stroud
Lessons and conclusions from dissecting the mechanism of a bisubstrate enzyme: thymidylate synthase mutagenesis, function, and structure.
Biochemistry 2003;42(2):248-56.
2003: Robert M Stroud; Janet S Finer-Moore
Conformational dynamics along an enzymatic reaction pathway: thymidylate synthase, "the movie".
Biochemistry 2003;42(2):239-47.
2003: Robert H O'Neil; Ryan H Lilien; Bruce Randall Donald; Robert M Stroud; Amy C Anderson
The crystal structure of dihydrofolate reductase-thymidylate synthase from Cryptosporidium hominis reveals a novel architecture for the bifunctional enzyme.
The Journal of eukaryotic microbiology 2003;50 Suppl():555-6.
2003: Robert M Stroud; peter nollert; Larry J W Miercke
The glycerol facilitator GlpF its aquaporin family of channels, and their selectivity.
Advances in protein chemistry 2003;63():291-316.
2002: Hu Pan; Shiou chuan Tsai; Eric S Meadows; Larry J W Miercke; Adrian T Keatinge-Clay; Joe O'Connell; Chaitan Khosla; Robert M Stroud
Crystal structure of the priming beta-ketosynthase from the R1128 polyketide biosynthetic pathway.
Structure (London, England : 1993) 2002;10(11):1559-68.
2002: Shiou-Chuan Tsai; Hongxiang Lu; David E Cane; Chaitan Khosla; Robert M Stroud
Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases.
Biochemistry 2002;41(42):12598-606.
2002: Ursula D Ramirez; George Minasov; Pamela J Focia; Robert M Stroud; Peter Walter; Peter Kuhn; Douglas Freymann
Structural basis for mobility in the 1.1 A crystal structure of the NG domain of Thermus aquaticus Ffh.
Journal of molecular biology 2002;320(4):783-99.
2002: M Paola Costi; Donatella Tondi; Marcella Rinaldi; Daniela Barlocco; Piergiorgio Pecorari; Fabrizia Soragni; Alberto Venturelli; Robert M Stroud
Structure-based studies on species-specific inhibition of thymidylate synthase.
Biochimica et biophysica acta 2002;1587(2-3):206-14.
2002: Timothy A Fritz; Lu Liu; Janet S Finer-Moore; Robert M Stroud
Tryptophan 80 and leucine 143 are critical for the hydride transfer step of thymidylate synthase by controlling active site access.
Biochemistry 2002;41(22):7021-9.
2002: Emadeddin Emadeddin Tajkhorshid; peter nollert; Morten Ø Jensen; Larry J W Miercke; Joseph O'Connell; Robert M Stroud; Klaus Schulten
Control of the selectivity of the aquaporin water channel family by global orientational tuning.
Science (New York, N.Y.) 2002;296(5567):525-30.
2002: Keith K. Reiling; Nicholas F Endres; Deborah S Dauber; Charles S Craik; Robert M Stroud
Anisotropic dynamics of the JE-2147-HIV protease complex: drug resistance and thermodynamic binding mode examined in a 1.09 A structure.
Biochemistry 2002;41(14):4582-94.
2002: Sanjay Agarwalla; James T Kealey; Daniel V Santi; Robert M Stroud
Characterization of the 23 S ribosomal RNA m5U1939 methyltransferase from Escherichia coli.
The Journal of biological chemistry 2002;277(11):8835-40.
2002: Dax Fu; Andrew Libson; Robert M Stroud
The structure of GlpF, a glycerol conducting channel.
Novartis Foundation symposium 2002;245():51-61; discussion 61-5, 165-8.
2001: Shiou-Chuan Tsai; Larry J W Miercke; Jolanta Krucinski; R Gokhale; Jeng-Chang Chen; Paul G Foster; D E Cane; Chaitan Khosla; Robert M Stroud
Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: versatility from a unique substrate channel.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(26):14808-13.
2001: PH Sayre; Janet S Finer-Moore; Timothy A Fritz; D Biermann; SB Gates; W C MacKellar; VF Patel; Robert M Stroud
Multi-targeted antifolates aimed at avoiding drug resistance form covalent closed inhibitory complexes with human and Escherichia coli thymidylate synthases.
Journal of molecular biology 2001;313(4):813-29.
2001: Timothy A Fritz; Donatella Tondi; Janet S Finer-Moore; M Paola Costi; Robert M Stroud
Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase.
Chemistry & biology 2001;8(10):981-95.
2001: peter nollert; William Harries; D Fu; Larry J W Miercke; Robert M Stroud
Atomic structure of a glycerol channel and implications for substrate permeation in aqua(glycero)porins.
FEBS letters 2001;504(3):112-7.
2001: R J Morse; T Yamamoto; Robert M Stroud
Structure of Cry2Aa suggests an unexpected receptor binding epitope.
Structure (London, England : 1993) 2001;9(5):409-17.
2001: Amy C Anderson; Robert H O'Neil; T S Surti; Robert M Stroud
Approaches to solving the rigid receptor problem by identifying a minimal set of flexible residues during ligand docking.
Chemistry & biology 2001;8(5):445-57.
2001: D B Lackey; M P Groziak; M Sergeeva; Malgorzata Beryt; C Boyer; Robert M Stroud; PH Sayre; J W Park; P Johnston; Dennis J Slamon; H Michael Shepard; Mark D Pegram
Enzyme-catalyzed therapeutic agent (ECTA) design: activation of the antitumor ECTA compound NB1011 by thymidylate synthase.
Biochemical pharmacology 2001;61(2):179-89.
2001: RJ Keenan; Douglas Freymann; Robert M Stroud; Peter Walter
The signal recognition particle.
Annual review of biochemistry 2001;70():755-75.
2000: Keith K. Reiling; Todd R Pray; Charles S Craik; Robert M Stroud
Functional consequences of the Kaposi's sarcoma-associated herpesvirus protease structure: regulation of activity and dimerization by conserved structural elements.
Biochemistry 2000;39(42):12796-803.
2000: D Fu; A Libson; Larry J W Miercke; cindy weitzman; peter nollert; Jolanta Krucinski; Robert M Stroud
Structure of a glycerol-conducting channel and the basis for its selectivity.
Science (New York, N.Y.) 2000;290(5491):481-6.
2000: Daniel A Erlanson; Andrew C Braisted; D R Raphael; Mike Randal; Robert M Stroud; E M Gordon; James A Wells
Site-directed ligand discovery.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(17):9367-72.
2000: S Kawase; S W Cho; J Rozelle; Robert M Stroud; Janet S Finer-Moore; Daniel V Santi
Replacement set mutagenesis of the four phosphate-binding arginine residues of thymidylate synthase.
Protein engineering 2000;13(8):557-63.
2000: Jeng-Chang Chen; Jolanta Krucinski; Larry J W Miercke; Janet S Finer-Moore; A H Tang; Andrew D Leavitt; Robert M Stroud
Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: a model for viral DNA binding.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(15):8233-8.
2000: Michael C Wiener; A S Verkman; Robert M Stroud; A N van Hoek
Mesoscopic surfactant organization and membrane protein crystallization.
Protein science : a publication of the Protein Society 2000;9(7):1407-9.
2000: A C Anderson; K M Perry; Douglas Freymann; Robert M Stroud
The crystal structure of thymidylate synthase from Pneumocystis carinii reveals a fungal insert important for drug design.
Journal of molecular biology 2000;297(3):645-57.
2000: P Variath; Yong Liu; T T Lee; Robert M Stroud; Daniel V Santi
Effects of subunit occupancy on partitioning of an intermediate in thymidylate synthase mutants.
Biochemistry 2000;39(10):2429-35.
2000: R J Morse; S Kawase; Daniel V Santi; Janet S Finer-Moore; Robert M Stroud
Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance".
Biochemistry 2000;39(5):1011-20.
2000: D B Cherbavaz; M E Lee; Robert M Stroud; D E Koshland
Active site water molecules revealed in the 2.1 A resolution structure of a site-directed mutant of isocitrate dehydrogenase.
Journal of molecular biology 2000;295(3):377-85.
2000: Paul G Foster; L Huang; Daniel V Santi; Robert M Stroud
The structural basis for tRNA recognition and pseudouridine formation by pseudouridine synthase I.
Nature structural biology 2000;7(1):23-7.
1999: Robert M Stroud; Peter Walter
Signal sequence recognition and protein targeting.
Current opinion in structural biology 1999;9(6):754-9.
1999: George J Turner; L J Miercke; A K Mitra; Robert M Stroud; M C Betlach; Ann M Winter-Vann
Expression, purification, and structural characterization of the bacteriorhodopsin-aspartyl transcarbamylase fusion protein.
Protein expression and purification 1999;17(2):324-38.
1999: Amy C Anderson; Robert H O'Neil; W L DeLano; Robert M Stroud
The structural mechanism for half-the-sites reactivity in an enzyme, thymidylate synthase, involves a relay of changes between subunits.
Biochemistry 1999;38(42):13829-36.
1999: Douglas Freymann; R J Keenan; Robert M Stroud; Peter Walter
Functional changes in the structure of the SRP GTPase on binding GDP and Mg2+GDP.
Nature structural biology 1999;6(8):793-801.
1999: P M Costi; Marcella Rinaldi; Donatella Tondi; Piergiorgio Pecorari; Daniela Barlocco; Stefano Ghelli; Robert M Stroud; Daniel V Santi; Thomas Stout; Chiara Musiu; E M Marangiu; Alessandra Pani; D Congiu; G A Loi; Paolo La Colla
Phthalein derivatives as a new tool for selectivity in thymidylate synthase inhibition.
Journal of medicinal chemistry 1999;42(12):2112-24.
1999: H Zhan; B Liu; S W Reid; Ken Aoki; C Li; Rashid Syed; C Karkaria; G Koe; K Sitney; K Hayenga; F Mistry; L Savel; M Dreyer; B A Katz; J Schreurs; DJ Matthews; Janet Cheetham; Joan C Egrie; L B Giebel; Robert M Stroud
Engineering a soluble extracellular erythropoietin receptor (EPObp) in Pichia pastoris to eliminate microheterogeneity, and its complex with erythropoietin.
Protein engineering 1999;12(6):505-13.
1999: Thomas Stout; Donatella Tondi; Marcella Rinaldi; Daniela Barlocco; Piergiorgio Pecorari; Daniel V Santi; Irwin D Kuntz; Robert M Stroud; Brian Shoichet; M Paola Costi
Structure-based design of inhibitors specific for bacterial thymidylate synthase.
Biochemistry 1999;38(5):1607-17.
1998: Christopher Reyes; CR Sage; Earl Rutenber; RM Nissen; Janet S Finer-Moore; Robert M Stroud
Inactivity of N229A thymidylate synthase due to water-mediated effects: isolating a late stage in methyl transfer.
Journal of molecular biology 1998;284(3):699-712.
1998: Thomas Stout; U Schellenberger; Daniel V Santi; Robert M Stroud
Crystal structures of a unique thermal-stable thymidylate synthase from Bacillus subtilis.
Biochemistry 1998;37(42):14736-47.
1998: Rashid Syed; S W Reid; C Li; Janet Cheetham; Ken Aoki; B Liu; H Zhan; Timothy D Osslund; A J Chirino; Jiandong Zhang; J Finer-Moore; Steve Elliott; K Sitney; B A Katz; DJ Matthews; J J Wendoloski; Joan C Egrie; Robert M Stroud
Efficiency of signalling through cytokine receptors depends critically on receptor orientation.
Nature 1998;395(6701):511-6.
1998: CR Sage; M D Michelitsch; Thomas Stout; D Biermann; RM Nissen; Janet S Finer-Moore; Robert M Stroud
D221 in thymidylate synthase controls conformation change, and thereby opening of the imidazolidine.
Biochemistry 1998;37(39):13893-901.
1998: Robert M Stroud; Keith K. Reiling; M Wiener; Douglas Freymann
Ion-channel-forming colicins.
Current opinion in structural biology 1998;8(4):525-33.
1998: C E Schafmeister; Robert M Stroud
Helical protein design.
Current opinion in biotechnology 1998;9(4):350-3.
1998: RJ Keenan; Douglas Freymann; Peter Walter; Robert M Stroud
Crystal structure of the signal sequence binding subunit of the signal recognition particle.
Cell 1998;94(2):181-91.
1998: Thomas Stout; CR Sage; Robert M Stroud
The additivity of substrate fragments in enzyme-ligand binding.
Structure (London, England : 1993) 1998;6(7):839-48.
1998: Jeng-Chang Chen; Larry J W Miercke; Jolanta Krucinski; JR Starr; G Saenz; X Wang; C A Spilburg; L G Lange; JL Ellsworth; Robert M Stroud
Structure of bovine pancreatic cholesterol esterase at 1.6 A: novel structural features involved in lipase activation.
Biochemistry 1998;37(15):5107-17.
1998: David L Birdsall; W Huang; Daniel V Santi; Robert M Stroud; Janet S Finer-Moore
The separate effects of E60Q in Lactobacillus casei thymidylate synthase delineate between mechanisms for formation of intermediates in catalysis.
Protein engineering 1998;11(3):171-83.
1998: R B Rose; Charles S Craik; Robert M Stroud
Domain flexibility in retroviral proteases: structural implications for drug resistant mutations.
Biochemistry 1998;37(8):2607-21.
1998: Janet S Finer-Moore; L Liu; David L Birdsall; Rachel B Brem; Javier Apfeld; Daniel V Santi; Robert M Stroud
Contributions of orientation and hydrogen bonding to catalysis in Asn229 mutants of thymidylate synthase.
Journal of molecular biology 1998;276(1):113-29.
1998: Bradley A Katz; James M Clark; J S Finer-Moore; T E Jenkins; C R Johnson; M J Ross; Christine Luong; Moore Bill; Robert M Stroud
Design of potent selective zinc-mediated serine protease inhibitors.
Nature 1998;391(6667):608-12.
1997: Sanjay Agarwalla; Sherry L. LaPorte; L Liu; Janet S Finer-Moore; Robert M Stroud; Daniel V Santi
A novel dCMP methylase by engineering thymidylate synthase.
Biochemistry 1997;36(50):15909-17.
1997: C E Schafmeister; Sherry L. LaPorte; Larry J W Miercke; Robert M Stroud
A designed four helix bundle protein with native-like structure.
Nature structural biology 1997;4(12):1039-46.
1997: Janet S Finer-Moore; Susan Tsutakawa; D R Cherbavaz; D C LaPorte; D E Koshland; Robert M Stroud
Access to phosphorylation in isocitrate dehydrogenase may occur by domain shifting.
Biochemistry 1997;36(45):13890-6.
1997: Earl Rutenber; J J De Voss; L Hoffman; Robert M Stroud; K H Lee; Juan Alvarez; F McPhee; Charles S Craik; Paul R. Ortiz de Montellano
The discovery, characterization and crystallographically determined binding mode of an FMOC-containing inhibitor of HIV-1 protease.
Bioorganic & medicinal chemistry 1997;5(7):1311-20.
1997: M Wiener; Douglas Freymann; P Ghosh; Robert M Stroud
Crystal structure of colicin Ia.
Nature 1997;385(6615):461-4.
1997: Douglas Freymann; RJ Keenan; Robert M Stroud; Peter Walter
Structure of the conserved GTPase domain of the signal recognition particle.
Nature 1997;385(6614):361-4.
1996: C R Sage; Earl Rutenber; Thomas Stout; Robert M Stroud
An essential role for water in an enzyme reaction mechanism: the crystal structure of the thymidylate synthase mutant E58Q.
Biochemistry 1996;35(50):16270-81.
1996: Earl Rutenber; Robert M Stroud
Binding of the anticancer drug ZD1694 to E. coli thymidylate synthase: assessing specificity and affinity.
Structure (London, England : 1993) 1996;4(11):1317-24.
1996: R B Rose; Charles S Craik; N L Douglas; Robert M Stroud
Three-dimensional structures of HIV-1 and SIV protease product complexes.
Biochemistry 1996;35(39):12933-44.
1996: Earl Rutenber; F McPhee; A P Kaplan; S L Gallion; J C Hogan; Charles S Craik; Robert M Stroud
A new class of HIV-1 protease inhibitor: the crystallographic structure, inhibition and chemical synthesis of an aminimide peptide isostere.
Bioorganic & medicinal chemistry 1996;4(9):1545-58.
1996: Robert M Stroud
Balancing ATP in the cell.
Nature structural biology 1996;3(7):567-9.
1996: Janet S Finer-Moore; L Liu; C E Schafmeister; D L Birdsall; T Mau; Daniel V Santi; Robert M Stroud
Partitioning roles of side chains in affinity, orientation, and catalysis with structures for mutant complexes: asparagine-229 in thymidylate synthase.
Biochemistry 1996;35(16):5125-36.
1996: P M Costi; L Liu; Janet S Finer-Moore; Robert M Stroud; Daniel V Santi
Asparagine 229 mutants of thymidylate synthase catalyze the methylation of 3-methyl-2'-deoxyuridine 5'-monophosphate.
Biochemistry 1996;35(13):3944-9.
1996: D L Birdsall; Janet S Finer-Moore; Robert M Stroud
Entropy in bi-substrate enzymes: proposed role of an alternate site in chaperoning substrate into, and products out of, thymidylate synthase.
Journal of molecular biology 1996;255(3):522-35.
1996: Thomas Stout; Robert M Stroud
The complex of the anti-cancer therapeutic, BW1843U89, with thymidylate synthase at 2.0 A resolution: implications for a new mode of inhibition.
Structure (London, England : 1993) 1996;4(1):67-77.
1996: Janet S Finer-Moore; E B Fauman; R J Morse; Daniel V Santi; Robert M Stroud
Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase.
Protein engineering 1996;9(1):69-75.
1995: C A Schiffer; I J Clifton; V J Davisson; Daniel V Santi; Robert M Stroud
Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site.
Biochemistry 1995;34(50):16279-87.
1995: Robert M Stroud; E B Fauman
Significance of structural changes in proteins: expected errors in refined protein structures.
Protein science : a publication of the Protein Society 1995;4(11):2392-404.
1995: Bradley A Katz; Robert M Stroud; N Collins; B Liu; R Arze
Topochemistry for preparing ligands that dimerize receptors.
Chemistry & biology 1995;2(9):591-600.
1995: Bradley A Katz; J Finer-Moore; R Mortezaei; D H Rich; Robert M Stroud
Episelection: novel Ki approximately nanomolar inhibitors of serine proteases selected by binding or chemistry on an enzyme surface.
Biochemistry 1995;34(26):8264-80.
1994: Janet S Finer-Moore; Gladys F Maley; Frank Maley; William R Montfort; Robert M Stroud
Crystal structure of thymidylate synthase from T4 phage: component of a deoxynucleoside triphosphate-synthesizing complex.
Biochemistry 1994;33(51):15459-68.
1994: P Ghosh; S F Mel; Robert M Stroud
The domain structure of the ion channel-forming protein colicin Ia.
Nature structural biology 1994;1(9):597-604.
1994: Robert M Stroud
An electrostatic highway.
Nature structural biology 1994;1(3):131-4.
1994: E B Fauman; Earl Rutenber; Gladys F Maley; Frank Maley; Robert M Stroud
Water-mediated substrate/product discrimination: the product complex of thymidylate synthase at 1.83 A.
Biochemistry 1994;33(6):1502-11.
1993: R B Rose; J R Rosé; R Salto; Charles S Craik; Robert M Stroud
Structure of the protease from simian immunodeficiency virus: complex with an irreversible nonpeptide inhibitor.
Biochemistry 1993;32(46):12498-507.
1993: C E Schafmeister; Larry J W Miercke; Robert M Stroud
Structure at 2.5 A of a designed peptide that maintains solubility of membrane proteins.
Science (New York, N.Y.) 1993;262(5134):734-8.
1993: S F Mel; Arnold M Falick; Al L Burlingame; Robert M Stroud
Mapping a membrane-associated conformation of colicin Ia.
Biochemistry 1993;32(36):9473-9.
1993: A K Mitra; Larry J W Miercke; George J Turner; R F Shand; M C Betlach; Robert M Stroud
Two-dimensional crystallization of Escherichia coli-expressed bacteriorhodopsin and its D96N variant: high resolution structural studies in projection.
Biophysical journal 1993;65(3):1295-306.
1993: Janet S Finer-Moore; E B Fauman; P G Foster; K M Perry; Daniel V Santi; Robert M Stroud
Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei.
Journal of molecular biology 1993;232(4):1101-16.
1993: K M Perry; C W Carreras; L C Chang; Daniel V Santi; Robert M Stroud
Structures of thymidylate synthase with a C-terminal deletion: role of the C-terminus in alignment of 2'-deoxyuridine 5'-monophosphate and 5,10-methylenetetrahydrofolate.
Biochemistry 1993;32(28):7116-25.
1993: P Ghosh; S F Mel; Robert M Stroud
A carboxy-terminal fragment of colicin Ia forms ion channels.
The Journal of membrane biology 1993;134(2):85-92.
1993: Robert M Stroud; Janet S Finer-Moore
Stereochemistry of a multistep/bipartite methyl transfer reaction: thymidylate synthase.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1993;7(8):671-7.
1993: Brian Shoichet; Robert M Stroud; Daniel V Santi; Irwin D Kuntz; K M Perry
Structure-based discovery of inhibitors of thymidylate synthase.
Science (New York, N.Y.) 1993;259(5100):1445-50.
1993: S F Mel; Robert M Stroud
Colicin Ia inserts into negatively charged membranes at low pH with a tertiary but little secondary structural change.
Biochemistry 1993;32(8):2082-9.
1993: George J Turner; Larry J W Miercke; TE Thorgeirsson; David S Kliger; M C Betlach; Robert M Stroud
Bacteriorhodopsin D85N: three spectroscopic species in equilibrium.
Biochemistry 1993;32(5):1332-7.
1992: A Kamb; Janet S Finer-Moore; Robert M Stroud
Cofactor triggers the conformational change in thymidylate synthase: implications for an ordered binding mechanism.
Biochemistry 1992;31(51):12876-84.
1992: A Kamb; Janet S Finer-Moore; A H Calvert; Robert M Stroud
Structural basis for recognition of polyglutamyl folates by thymidylate synthase.
Biochemistry 1992;31(41):9883-90.
1992: K M Perry; M Pookanjanatavip; J Zhao; Daniel V Santi; Robert M Stroud
Reversible dissociation and unfolding of the dimeric protein thymidylate synthase.
Protein science : a publication of the Protein Society 1992;1(6):796-800.
1992: Janet S Finer-Moore; Anthony A Kossiakoff; James H Hurley; T Earnest; Robert M Stroud
Solvent structure in crystals of trypsin determined by X-ray and neutron diffraction.
Proteins 1992;12(3):203-22.
1992: C A Schiffer; J W Caldwell; Robert M Stroud; Peter A Kollman
Inclusion of solvation free energy with molecular mechanics energy: alanyl dipeptide as a test case.
Protein science : a publication of the Protein Society 1992;1(3):396-400.
1991: TE Thorgeirsson; S J Milder; Larry J W Miercke; M C Betlach; R F Shand; Robert M Stroud; David S Kliger
Effects of Asp-96----Asn, Asp-85----Asn, and Arg-82----Gln single-site substitutions on the photocycle of bacteriorhodopsin.
Biochemistry 1991;30(38):9133-42.
1991: James H Hurley; A M Dean; D E Koshland; Robert M Stroud
Catalytic mechanism of NADP(+)-dependent isocitrate dehydrogenase: implications from the structures of magnesium-isocitrate and NADP+ complexes.
Biochemistry 1991;30(35):8671-8.
1991: Irit Lax; A K Mitra; C Ravera; D R Hurwitz; M Rubinstein; A Ullrich; Robert M Stroud; Joseph Schlessinger
Epidermal growth factor (EGF) induces oligomerization of soluble, extracellular, ligand-binding domain of EGF receptor. A low resolution projection structure of the ligand-binding domain.
The Journal of biological chemistry 1991;266(21):13828-33.
1991: C A Schiffer; V J Davisson; Daniel V Santi; Robert M Stroud
Crystallization of human thymidylate synthase.
Journal of molecular biology 1991;219(2):161-3.
1991: P Ghosh; Robert M Stroud
Ion channels formed by a highly charged peptide.
Biochemistry 1991;30(14):3551-7.
1991: R F Shand; Larry J W Miercke; A K Mitra; S K Fong; Robert M Stroud; M C Betlach
Wild-type and mutant bacterioopsins D85N, D96N, and R82Q: high-level expression in Escherichia coli.
Biochemistry 1991;30(12):3082-8.
1991: Larry J W Miercke; M C Betlach; A K Mitra; R F Shand; S K Fong; Robert M Stroud
Wild-type and mutant bacteriorhodopsins D85N, D96N, and R82Q: purification to homogeneity, pH dependence of pumping, and electron diffraction.
Biochemistry 1991;30(12):3088-98.
1991: S W Lin; S P Fodor; Larry J W Miercke; R F Shand; M C Betlach; Robert M Stroud; Richard A Mathies
Resonance Raman spectra of bacteriorhodopsin mutants with substitutions at Asp-85, Asp-96, and Arg-82.
Photochemistry and photobiology 1991;53(3):341-6.
1991: S J Milder; TE Thorgeirsson; Larry J W Miercke; Robert M Stroud; David S Kliger
Effects of detergent environments on the photocycle of purified monomeric bacteriorhodopsin.
Biochemistry 1991;30(7):1751-61.
1990: Robert M Stroud; Michael McCarthy; M Shuster
Nicotinic acetylcholine receptor superfamily of ligand-gated ion channels.
Biochemistry 1990;29(50):11009-23.
1990: S Climie; Luis M Ruiz-Perez; D Gonzalez-Pacanowska; P Prapunwattana; S W Cho; Robert M Stroud; Daniel V Santi
Saturation site-directed mutagenesis of thymidylate synthase.
The Journal of biological chemistry 1990;265(31):18776-9.
1990: W F Mangel; P T Singer; D M Cyr; T C Umland; D L Toledo; Robert M Stroud; J W Pflugrath; Robert M Sweet
Structure of an acyl-enzyme intermediate during catalysis: (guanidinobenzoyl)trypsin.
Biochemistry 1990;29(36):8351-7.
1990: James H Hurley; A M Dean; Julie L Sohl; D E Koshland; Robert M Stroud
Regulation of an enzyme by phosphorylation at the active site.
Science (New York, N.Y.) 1990;249(4972):1012-6.
1990: Janet S Finer-Moore; William R Montfort; Robert M Stroud
Pairwise specificity and sequential binding in enzyme catalysis: thymidylate synthase.
Biochemistry 1990;29(30):6977-86.
1990: William R Montfort; K M Perry; E B Fauman; Janet S Finer-Moore; Gladys F Maley; L Hardy; Frank Maley; Robert M Stroud
Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate.
Biochemistry 1990;29(30):6964-77.
1990: James H Hurley; A M Dean; P E Thorsness; D E Koshland; Robert M Stroud
Regulation of isocitrate dehydrogenase by phosphorylation involves no long-range conformational change in the free enzyme.
The Journal of biological chemistry 1990;265(7):3599-602.
1990: A K Mitra; Robert M Stroud
High sensitivity electron diffraction analysis. A study of divalent cation binding to purple membrane.
Biophysical journal 1990;57(2):301-11.
1990: C A Schiffer; J W Caldwell; Peter A Kollman; Robert M Stroud
Prediction of homologous protein structures based on conformational searches and energetics.
Proteins 1990;8(1):30-43.
1990: K M Perry; E B Fauman; Janet S Finer-Moore; William R Montfort; Gladys F Maley; Frank Maley; Robert M Stroud
Plastic adaptation toward mutations in proteins: structural comparison of thymidylate synthases.
Proteins 1990;8(4):315-33.
1989: Larry J W Miercke; Robert M Stroud; Edward A Dratz
Preparative purification of functional bacteriorhodopsin by high-performance size-exclusion chromatography.
Journal of chromatography 1989;483():331-40.
1989: James H Hurley; P E Thorsness; V Ramalingam; N H Helmers; D E Koshland; Robert M Stroud
Structure of a bacterial enzyme regulated by phosphorylation, isocitrate dehydrogenase.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(22):8635-9.
1989: L Poulter; J P Earnest; Robert M Stroud; Al L Burlingame
Structure, oligosaccharide structures, and posttranslationally modified sites of the nicotinic acetylcholine receptor.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(17):6645-9.
1989: A K Mitra; Michael McCarthy; Robert M Stroud
Three-dimensional structure of the nicotinic acetylcholine receptor and location of the major associated 43-kD cytoskeletal protein, determined at 22 A by low dose electron microscopy and x-ray diffraction to 12.5 A.
The Journal of cell biology 1989;109(2):755-74.
1989: Michael McCarthy; Robert M Stroud
Changes in conformation upon agonist binding, and nonequivalent labeling, of the membrane-spanning regions of the nicotinic acetylcholine receptor subunits.
The Journal of biological chemistry 1989;264(18):10911-6.
1989: Larry J W Miercke; P E Ross; Robert M Stroud; Edward A Dratz
Purification of bacteriorhodopsin and characterization of mature and partially processed forms.
The Journal of biological chemistry 1989;264(13):7531-5.
1989: Michael McCarthy; Robert M Stroud
Conformational states of the nicotinic acetylcholine receptor from Torpedo californica induced by the binding of agonists, antagonists, and local anesthetics. Equilibrium measurements using tritium-hydrogen exchange.
Biochemistry 1989;28(1):40-8.
1988: L Poulter; J P Earnest; Robert M Stroud; Al L Burlingame
Cesium ion liquid secondary ion mass spectrometry of membrane-bound glycoproteins: structural and topological considerations of acetylcholine receptor from Torpedo californica.
Biomedical & environmental mass spectrometry 1988;16(1-12):25-30.
1988: M E Basson; M Thorsness; J Finer-Moore; Robert M Stroud; Jasper Rine
Structural and functional conservation between yeast and human 3-hydroxy-3-methylglutaryl coenzyme A reductases, the rate-limiting enzyme of sterol biosynthesis.
Molecular and cellular biology 1988;8(9):3797-808.
1988: V J Basus; M Billeter; R A Love; Robert M Stroud; Irwin D Kuntz
Structural studies of alpha-bungarotoxin. 1. Sequence-specific 1H NMR resonance assignments.
Biochemistry 1988;27(8):2763-71.
1987: Stephen R Sprang; T Standing; Robert J Fletterick; Robert M Stroud; J Finer-Moore; Nguyen-Huu Xuong; R Hamlin; W J Rutter; Charles S Craik
The three-dimensional structure of Asn102 mutant of trypsin: role of Asp102 in serine protease catalysis.
Science (New York, N.Y.) 1987;237(4817):905-9.
1987: L W Hardy; Janet S Finer-Moore; William R Montfort; M O Jones; Daniel V Santi; Robert M Stroud
Atomic structure of thymidylate synthase: target for rational drug design.
Science (New York, N.Y.) 1987;235(4787):448-55.
1987: Robert M Stroud
An archetypal molecular transducer of the nervous system: the acetylcholine receptor.
Research publications - Association for Research in Nervous and Mental Disease 1987;65():51-63.
1987: Robert M Stroud
Topological mapping and the ionic channel in an acetylcholine receptor.
Society of General Physiologists series 1987;41():67-75.
1986: R A Love; Robert M Stroud
The crystal structure of alpha-bungarotoxin at 2.5 A resolution: relation to solution structure and binding to acetylcholine receptor.
Protein engineering 1986;1(1):37-46.
1986: S B Masters; Robert M Stroud; Henry R Bourne
Family of G protein alpha chains: amphipathic analysis and predicted structure of functional domains.
Protein engineering 1986;1(1):47-54.
1986: N V Katre; Y Kimura; Robert M Stroud
Cation binding sites on the projected structure of bacteriorhodopsin.
Biophysical journal 1986;50(2):277-84.
1986: Robert H Fairclough; R C Miake-Lye; Robert M Stroud; Keith O Hodgson; Sebastian Doniach
Location of terbium binding sites on acetylcholine receptor-enriched membranes.
Journal of molecular biology 1986;189(4):673-80.
1986: R S Panush; Robert M Stroud; E M Webster
Food-induced (allergic) arthritis. Inflammatory arthritis exacerbated by milk.
Arthritis and rheumatism 1986;29(2):220-6.
1986: Michael McCarthy; J P Earnest; E F Young; S Choe; Robert M Stroud
The molecular neurobiology of the acetylcholine receptor.
Annual review of neuroscience 1986;9():383-413.
1985: L Liscum; J Finer-Moore; Robert M Stroud; Kenneth Luskey; Michael S Brown; Joseph L Goldstein
Domain structure of 3-hydroxy-3-methylglutaryl coenzyme A reductase, a glycoprotein of the endoplasmic reticulum.
The Journal of biological chemistry 1985;260(1):522-30.
1985: E F Young; E Ralston; J Blake; J Ramachandran; ZW Hall; Robert M Stroud
Topological mapping of acetylcholine receptor: evidence for a model with five transmembrane segments and a cytoplasmic COOH-terminal peptide.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(2):626-30.
1985: Robert M Stroud; J Finer-Moore
Acetylcholine receptor structure, function, and evolution.
Annual review of cell biology 1985;1():317-51.
1984: N V Katre; J Finer-Moore; Robert M Stroud; S B Hayward
Location of an extrinsic label in the primary and tertiary structure of bacteriorhodopsin.
Biophysical journal 1984;46(2):195-203.
1984: Janet S Finer-Moore; Robert M Stroud; B Prescott; G J Thomas
Subunit secondary structure in filamentous viruses: predictions and observations.
Journal of biomolecular structure & dynamics 1984;2(1):93-100.
1984: J Finer-Moore; Robert M Stroud
Amphipathic analysis and possible formation of the ion channel in an acetylcholine receptor.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(1):155-9.
1983: Robert H Fairclough; J Finer-Moore; R A Love; D Kristofferson; P J Desmeules; Robert M Stroud
Subunit organization and structure of an acetylcholine receptor.
Cold Spring Harbor symposia on quantitative biology 1983;48 Pt 1():9-20.
1982: D A Agard; Robert M Stroud
Linking regions between helices in bacteriorhodopsin revealed.
Biophysical journal 1982;37(3):589-602.
1982: J Kistler; Robert M Stroud; Michael Klymkowsky; R A Lalancette; Robert H Fairclough
Structure and function of an acetylcholine receptor.
Biophysical journal 1982;37(1):371-83.
1981: Robert M Stroud; Philip Serwer; M J Ross
Assembly of bacteriophage T7. Dimensions of the bacteriophage and its capsids.
Biophysical journal 1981;36(3):743-57.
1981: S B Hayward; Robert M Stroud
Projected structure of purple membrane determined to 3.7 A resolution by low temperature electron microscopy.
Journal of molecular biology 1981;151(3):491-517.
1981: J Tobler; M Krieger; Robert M Stroud
The binding and processing of plasminogen by Balb/c 3T3 and SV3T3 cells.
Journal of cellular physiology 1981;108(2):277-90.
1981: L Silvestri; J R Baker; L Rodén; Robert M Stroud
The C1q inhibitor in serum is a chondroitin 4-sulfate proteoglycan.
The Journal of biological chemistry 1981;256(14):7383-7.
1981: N V Katre; P K Wolber; W Stoeckenius; Robert M Stroud
Attachment site(s) of retinal in bacteriorhodopsin.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(7):4068-72.
1981: J Kistler; Robert M Stroud
Crystalline arrays of membrane-bound acetylcholine receptor.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(6):3678-82.
1981: D A Agard; R A Steinberg; Robert M Stroud
Quantitative analysis of electrophoretograms: a mathematical approach to super-resolution.
Analytical biochemistry 1981;111(2):257-68.
1980: S Nagasawa; Robert M Stroud
Purification and characterization of a macromolecular weight cofactor for C3b-inactivator, C4bC3bINA-cofactor, of human plasma.
Molecular immunology 1980;17(11):1365-72.
1980: S Nagasawa; C Ichihara; Robert M Stroud
Cleavage of C4b by C3b inactivator: production of a nicked form of C4b, C4b', as an intermediate cleavage product of C4b by C3b inactivator.
Journal of immunology (Baltimore, Md. : 1950) 1980;125(2):578-82.
1980: R M Des Prez; S Steckley; Robert M Stroud; Jack Hawiger
Interaction of Histoplasma capsulatum with human platelets.
The Journal of infectious diseases 1980;142(1):32-9.
1980: Michael Klymkowsky; John Edward Heuser; Robert M Stroud
Protease effects on the structure of acetylcholine receptor membranes from Torpedo californica.
The Journal of cell biology 1980;85(3):823-38.
1979: Michael Klymkowsky; Robert M Stroud
Immunospecific identification and three-dimensional structure of a membrane-bound acetylcholine receptor from Torpedo californica.
Journal of molecular biology 1979;128(3):319-34.
1979: Robert M Stroud; D A Agard
Structure determination of asymmetric membrane profiles using an iterative Fourier method.
Biophysical journal 1979;25(3):495-512.
1977: M J Ross; Michael Klymkowsky; D A Agard; Robert M Stroud
Structural studies of a membrane-bound acetylcholine receptor from Torpedo californica.
Journal of molecular biology 1977;116(4):635-59.
1977: A A Kossiakoff; J L Chambers; L M Kay; Robert M Stroud
Structure of bovine trypsinogen at 1.9 A resolution.
Biochemistry 1977;16(4):654-64.
1975: R E Koeppe; Robert M Stroud
A pulsed diffusion technique for the growth of protein crystals for x-ray diffraction.
Journal of molecular biology 1975;98(1):155-60.
1974: M M Hurst; J E Volanakis; R B Hester; Robert M Stroud; J C Bennett
The structural basis for binding of complement by immunoglobulin M.
The Journal of experimental medicine 1974;140(4):1117-21.
1974: J L Chambers; G G Christoph; M Krieger; L Kay; Robert M Stroud
Silver ion inhibition of serine proteases: crystallographic study of silver-trypsin.
Biochemical and biophysical research communications 1974;59(1):70-4.
1974: M Krieger; L M Kay; Robert M Stroud
Structure and specific binding of trypsin: comparison of inhibited derivatives and a model for substrate binding.
Journal of molecular biology 1974;83(2):209-30.
1974: Robert M Stroud; L M Kay; R E Dickerson
The structure of bovine trypsin: electron density maps of the inhibited enzyme at 5 Angstrom and at 2-7 Angstron resolution.
Journal of molecular biology 1974;83(2):185-208.
1972: J E Volanakis; Robert M Stroud
Rabbit C1q: purification, functional and structural studies.
Journal of immunological methods 1972;2(1):25-34.
1972: K Yonemasu; Robert M Stroud
Structural studies on human Clq: non-covalent and covalent subunits.
Immunochemistry 1972;9(5):545-54.
1972: Robert M Stroud; L M Kay; R E Dickerson
The crystal and molecular structure of DIP-inhibited bovine trypsin at2.7Angstrom resolution.
Cold Spring Harbor symposia on quantitative biology 1972;36():125-40.
1972: E Shelton; K Yonemasu; Robert M Stroud
Ultrastructure of the human complement component, Clq (negative staining-glutamine synthetase-biologically active Clq).
Proceedings of the National Academy of Sciences of the United States of America 1972;69(1):65-8.
1970: R J Pickering; G B Naff; Robert M Stroud; R A Good; H Gewurz
Deficiency of C1r in human serum. Effects on the structure and function of macromolecular C1.
The Journal of experimental medicine 1970;131(4):803-15.