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Kevin Struhl

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Living Beings

Saccharomyces cerevisiae

Chemicals & Drugs

Physiology

Concepts & Ideas

Molecular Sequence Data

Genes & Molecular Sequences

Anatomy

Chromatin

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Co-Publications
Name
16
Moqtaderi, Zarmik
9
Geisberg, Joseph
8
Ng, Huck-Hui
8
Wade, Joseph
6
Proft, Markus
5
Sekinger, Edward
5
Kuras, Laurent
5
Lee, M
5
Keaveney, M
5
Cormack, Brendan
4
Church, George
4
Gingeras, Thomas
4
Kadosh, David
3
Young, Richard
3
Zhang, Yi

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Publications

TOP 3
Iliopoulos Dimitrios; Hirsch Heather A; Struhl Kevin
An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation.
Hirsch Heather A; Iliopoulos Dimitrios; Tsichlis Philip N; Struhl Kevin
Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission.
Auerbach Raymond K; Euskirchen Ghia; Rozowsky Joel; Lamarre-Vincent Nathan; Moqtaderi Zarmik; Lefrançois Philippe; Struhl Kevin; Gerstein Mark; Snyder Michael
Mapping accessible chromatin regions using Sono-Seq.

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All Publications

2009: Iliopoulos Dimitrios; Hirsch Heather A; Struhl Kevin
An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation.
Cell 2009;139(4):693-706.
2009: Hirsch Heather A; Iliopoulos Dimitrios; Tsichlis Philip N; Struhl Kevin
Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission.
Cancer research 2009;69(19):7507-11.
2009: Auerbach Raymond K; Euskirchen Ghia; Rozowsky Joel; Lamarre-Vincent Nathan; Moqtaderi Zarmik; Lefrançois Philippe; Struhl Kevin; Gerstein Mark; Snyder Michael
Mapping accessible chromatin regions using Sono-Seq.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(35):14926-31.
2009: Zhang Yong; Moqtaderi Zarmik; Rattner Barbara P; Euskirchen Ghia; Snyder Michael; Kadonaga James T; Liu X Shirley; Struhl Kevin
Intrinsic histone-DNA interactions are not the major determinant of nucleosome positions in vivo.
Nature structural & molecular biology 2009;16(8):847-52.
2009: Iliopoulos Dimitrios; Polytarchou Christos; Hatziapostolou Maria; Kottakis Filippos; Maroulakou Ioanna G; Struhl Kevin; Tsichlis Philip N
MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells.
Science signaling 2009;2(92):ra62.
2009: Fan Xiaochun; Struhl Kevin
Where does mediator bind in vivo?
PloS one 2009;4(4):e5029.
2008: Fan Xiaochun; Lamarre-Vincent Nathan; Wang Qian; Struhl Kevin
Extensive chromatin fragmentation improves enrichment of protein binding sites in chromatin immunoprecipitation experiments.
Nucleic acids research 2008;36(19):e125.
2008: Struhl Kevin
The hisB463 mutation and expression of a eukaryotic protein in Escherichia coli.
Genetics 2008;180(2):709-14.
2008: Madhani Hiten D; Francis Nicole J; Kingston Robert E; Kornberg Roger D; Moazed Danesh; Narlikar Geeta J; Panning Barbara; Struhl Kevin
Epigenomics: a roadmap, but to where?
Science (New York, N.Y.) 2008;322(5898):43-4.
2008: Miotto Benoit; Struhl Kevin
HBO1 histone acetylase is a coactivator of the replication licensing factor Cdt1.
Genes & development 2008;22(19):2633-8.
2008: Thakur Jitendra K; Arthanari Haribabu; Yang Fajun; Pan Shih-Jung; Fan Xiaochun; Breger Julia; Frueh Dominique P; Gulshan Kailash; Li Darrick K; Mylonakis Eleftherios; Struhl Kevin; Moye-Rowley W Scott; Cormack Brendan P; Wagner Gerhard; Näär Anders M
A nuclear receptor-like pathway regulating multidrug resistance in fungi.
Nature 2008;452(7187):604-9.
2008: Moqtaderi Zarmik; Struhl Kevin
Expanding the repertoire of plasmids for PCR-mediated epitope tagging in yeast.
Yeast (Chichester, England) 2008;25(4):287-92.
2008: Wade Joseph T; Struhl Kevin
The transition from transcriptional initiation to elongation.
Current opinion in genetics & development 2008;18(2):130-6.
2008: Struhl Kevin
Kevin Struhl. Interview.
Current biology : CB 2008;18(1):R7-9.
2007: Schwabish Marc A; Struhl Kevin
The Swi/Snf complex is important for histone eviction during transcriptional activation and RNA polymerase II elongation in vivo.
Molecular and cellular biology 2007;27(20):6987-95.
2007: Miotto Benoit; Struhl Kevin
[Histone H4 lysine 16 acetylation: from genome regulation to tumoral progression]
Médecine sciences : M/S 2007;23(8-9):735-40.
2007: Wade Joseph T; Struhl Kevin; Busby Stephen J W; Grainger David C
Genomic analysis of protein-DNA interactions in bacteria: insights into transcription and chromosome organization.
Molecular microbiology 2007;65(1):21-6.
2007: Struhl Kevin
Transcriptional noise and the fidelity of initiation by RNA polymerase II.
Nature structural & molecular biology 2007;14(2):103-5.
2007: Ghosh Srinka; Hirsch Heather A; Sekinger Edward A; Kapranov Philipp; Struhl Kevin; Gingeras Thomas R
Differential analysis for high density tiling microarray data.
BMC bioinformatics 2007;8():359.
2006: Reppas Nikos B; Wade Joseph T; Church George M; Struhl Kevin
The transition between transcriptional initiation and elongation in E. coli is highly variable and often rate limiting.
Molecular cell 2006;24(5):747-57.
2006: Yang Annie; Zhu Zhou; Kapranov Philipp; McKeon Frank; Church George M; Gingeras Thomas R; Struhl Kevin
Relationships between p63 binding, DNA sequence, transcription activity, and biological function in human cells.
Molecular cell 2006;24(4):593-602.
2006: Pascual-Ahuir Amparo; Struhl Kevin; Proft Markus
Genome-wide location analysis of the stress-activated MAP kinase Hog1 in yeast.
Methods (San Diego, Calif.) 2006;40(3):272-8.
2006: Wade Joseph T; Roa Daniel Castro; Grainger David C; Hurd Douglas; Busby Stephen J W; Struhl Kevin; Nudler Evgeny
Extensive functional overlap between sigma factors in Escherichia coli.
Nature structural & molecular biology 2006;13(9):806-14.
2006: Miotto Benoit; Struhl Kevin
Differential gene regulation by selective association of transcriptional coactivators and bZIP DNA-binding domains.
Molecular and cellular biology 2006;26(16):5969-82.
2006: Proft Markus; Mas Glòria; de Nadal Eulàlia; Vendrell Alexandre; Noriega Núria; Struhl Kevin; Posas Francesc
The stress-activated Hog1 kinase is a selective transcriptional elongation factor for genes responding to osmotic stress.
Molecular cell 2006;23(2):241-50.
2006: Schwabish Marc A; Struhl Kevin
Asf1 mediates histone eviction and deposition during elongation by RNA polymerase II.
Molecular cell 2006;22(3):415-22.
2006: Hall Daniel B; Wade Joseph T; Struhl Kevin
An HMG protein, Hmo1, associates with promoters of many ribosomal protein genes and throughout the rRNA gene locus in Saccharomyces cerevisiae.
Molecular and cellular biology 2006;26(9):3672-9.
2006: Fan Xiaochun; Chou Danny M; Struhl Kevin
Activator-specific recruitment of Mediator in vivo.
Nature structural & molecular biology 2006;13(2):117-20.
2006: Ghosh Srinka; Hirsch Heather A; Sekinger Edward; Struhl Kevin; Gingeras Thomas R
Rank-statistics based enrichment-site prediction algorithm developed for chromatin immunoprecipitation on chip experiments.
BMC bioinformatics 2006;7():434.
2005: Joshi Amita A; Struhl Kevin
Eaf3 chromodomain interaction with methylated H3-K36 links histone deacetylation to Pol II elongation.
Molecular cell 2005;20(6):971-8.
2005: Wade Joseph T; Reppas Nikos B; Church George M; Struhl Kevin
Genomic analysis of LexA binding reveals the permissive nature of the Escherichia coli genome and identifies unconventional target sites.
Genes & development 2005;19(21):2619-30.
2005: Proft Markus; Gibbons Francis D; Copeland Matthew; Roth Frederick P; Struhl Kevin
Genomewide identification of Sko1 target promoters reveals a regulatory network that operates in response to osmotic stress in Saccharomyces cerevisiae.
Eukaryotic cell 2005;4(8):1343-52.
2005: Sekinger Edward A; Moqtaderi Zarmik; Struhl Kevin
Intrinsic histone-DNA interactions and low nucleosome density are important for preferential accessibility of promoter regions in yeast.
Molecular cell 2005;18(6):735-48.
2005: Katan-Khaykovich Yael; Struhl Kevin
Heterochromatin formation involves changes in histone modifications over multiple cell generations.
The EMBO journal 2005;24(12):2138-49.
2005: Geisberg Joseph V; Struhl Kevin
Analysis of protein co-occupancy by quantitative sequential chromatin immunoprecipitation.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2005;Chapter 21():Unit 21.8.
2005: Mason Paul B; Struhl Kevin
Distinction and relationship between elongation rate and processivity of RNA polymerase II in vivo.
Molecular cell 2005;17(6):831-40.
2005: Struhl Kevin
Transcriptional activation: mediator can act after preinitiation complex formation.
Molecular cell 2005;17(6):752-4.
2005: Aparicio Oscar; Geisberg Joseph V; Sekinger Edward; Yang Annie; Moqtaderi Zarmik; Struhl Kevin
Chromatin immunoprecipitation for determining the association of proteins with specific genomic sequences in vivo.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2005;Chapter 21():Unit 21.3.
2005: Gibbons Francis D; Proft Markus; Struhl Kevin; Roth Frederick P
Chipper: discovering transcription-factor targets from chromatin immunoprecipitation microarrays using variance stabilization.
Genome biology 2005;6(11):R96.
2004: Wade Joseph T; Hall Daniel B; Struhl Kevin
The transcription factor Ifh1 is a key regulator of yeast ribosomal protein genes.
Nature 2004;432(7020):1054-8.
2004: Wade Joseph T; Struhl Kevin
Association of RNA polymerase with transcribed regions in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(51):17777-82.
2004: Schwabish Marc A; Struhl Kevin
Evidence for eviction and rapid deposition of histones upon transcriptional elongation by RNA polymerase II.
Molecular and cellular biology 2004;24(23):10111-7.
2004: Moqtaderi Zarmik; Struhl Kevin
Defining in vivo targets of nuclear proteins by chromatin immunoprecipitation and microarray analysis.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2004;Chapter 21():Unit 21.9.
2004: Grainger David C; Overton Timothy W; Reppas Nikos; Wade Joseph T; Tamai Eiji; Hobman Jon L; Constantinidou Chrystala; Struhl Kevin; Church George; Busby Stephen J W
Genomic studies with Escherichia coli MelR protein: applications of chromatin immunoprecipitation and microarrays.
Journal of bacteriology 2004;186(20):6938-43.
2004: Aparicio Oscar; Geisberg Joseph V; Struhl Kevin
Chromatin immunoprecipitation for determining the association of proteins with specific genomic sequences in vivo.
Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.] 2004;Chapter 17():Unit 17.7.
2004: Proft Markus; Struhl Kevin
MAP kinase-mediated stress relief that precedes and regulates the timing of transcriptional induction.
Cell 2004;118(3):351-61.
2004: Geisberg Joseph V; Struhl Kevin
Cellular stress alters the transcriptional properties of promoter-bound Mot1-TBP complexes.
Molecular cell 2004;14(4):479-89.
2004: Moqtaderi Zarmik; Struhl Kevin
Genome-wide occupancy profile of the RNA polymerase III machinery in Saccharomyces cerevisiae reveals loci with incomplete transcription complexes.
Molecular and cellular biology 2004;24(10):4118-27.
2004: Cawley Simon; Bekiranov Stefan; Ng Huck H; Kapranov Philipp; Sekinger Edward A; Kampa Dione; Piccolboni Antonio; Sementchenko Victor; Cheng Jill; Williams Alan J; Wheeler Raymond; Wong Brant; Drenkow Jorg; Yamanaka Mark; Patel Sandeep; Brubaker Shane; Tammana Hari; Helt Gregg; Struhl Kevin; Gingeras Thomas R
Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs.
Cell 2004;116(4):499-509.
2004: Reid Juliet L; Moqtaderi Zarmik; Struhl Kevin
Eaf3 regulates the global pattern of histone acetylation in Saccharomyces cerevisiae.
Molecular and cellular biology 2004;24(2):757-64.
2004: Geisberg Joseph V; Struhl Kevin
Quantitative sequential chromatin immunoprecipitation, a method for analyzing co-occupancy of proteins at genomic regions in vivo.
Nucleic acids research 2004;32(19):e151.
2003: Mason Paul B; Struhl Kevin
The FACT complex travels with elongating RNA polymerase II and is important for the fidelity of transcriptional initiation in vivo.
Molecular and cellular biology 2003;23(22):8323-33.
2003: Ng Huck Hui; Dole Sudhanshu; Struhl Kevin
The Rtf1 component of the Paf1 transcriptional elongation complex is required for ubiquitination of histone H2B.
The Journal of biological chemistry 2003;278(36):33625-8.
2003: Ng Huck Hui; Robert François; Young Richard A; Struhl Kevin
Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity.
Molecular cell 2003;11(3):709-19.
2003: Ng Huck Hui; Ciccone David N; Morshead Katrina B; Oettinger Marjorie A; Struhl Kevin
Lysine-79 of histone H3 is hypomethylated at silenced loci in yeast and mammalian cells: a potential mechanism for position-effect variegation.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(4):1820-5.
2002: Geisberg Joseph V; Moqtaderi Zarmik; Kuras Laurent; Struhl Kevin
Mot1 associates with transcriptionally active promoters and inhibits association of NC2 in Saccharomyces cerevisiae.
Molecular and cellular biology 2002;22(23):8122-34.
2002: Hall Daniel B; Struhl Kevin
The VP16 activation domain interacts with multiple transcriptional components as determined by protein-protein cross-linking in vivo.
The Journal of biological chemistry 2002;277(48):46043-50.
2002: Deckert Jutta; Struhl Kevin
Targeted recruitment of Rpd3 histone deacetylase represses transcription by inhibiting recruitment of Swi/Snf, SAGA, and TATA binding protein.
Molecular and cellular biology 2002;22(18):6458-70.
2002: Ng Huck Hui; Xu Rui-Ming; Zhang Yi; Struhl Kevin
Ubiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3 lysine 79.
The Journal of biological chemistry 2002;277(38):34655-7.
2002: Feng Qin; Wang Hengbin; Ng Huck Hui; Erdjument-Bromage Hediye; Tempst Paul; Struhl Kevin; Zhang Yi
Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain.
Current biology : CB 2002;12(12):1052-8.
2002: Proft Markus; Struhl Kevin
Hog1 kinase converts the Sko1-Cyc8-Tup1 repressor complex into an activator that recruits SAGA and SWI/SNF in response to osmotic stress.
Molecular cell 2002;9(6):1307-17.
2002: Ng Huck Hui; Feng Qin; Wang Hengbin; Erdjument-Bromage Hediye; Tempst Paul; Zhang Yi; Struhl Kevin
Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association.
Genes & development 2002;16(12):1518-27.
2002: Mencía Mario; Moqtaderi Zarmik; Geisberg Joseph V; Kuras Laurent; Struhl Kevin
Activator-specific recruitment of TFIID and regulation of ribosomal protein genes in yeast.
Molecular cell 2002;9(4):823-33.
2002: Ng Huck Hui; Robert François; Young Richard A; Struhl Kevin
Genome-wide location and regulated recruitment of the RSC nucleosome-remodeling complex.
Genes & development 2002;16(7):806-19.
2002: Katan-Khaykovich Yael; Struhl Kevin
Dynamics of global histone acetylation and deacetylation in vivo: rapid restoration of normal histone acetylation status upon removal of activators and repressors.
Genes & development 2002;16(6):743-52.
2001: Struhl K
Gene regulation. A paradigm for precision.
Science (New York, N.Y.) 2001;293(5532):1054-5.
2001: Kulish D; Struhl K
TFIIS enhances transcriptional elongation through an artificial arrest site in vivo.
Molecular and cellular biology 2001;21(13):4162-8.
2001: Struhl K
Reagents and radioisotopes used to manipulate nucleic acids.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2001;Chapter 10():Unit 10.9.
2001: Seidman C E; Struhl K
Introduction of plasmid DNA into cells.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2001;Appendix 4():4D.
2001: Seidman C E; Struhl K
Introduction of plasmid DNA into cells.
Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.] 2001;Appendix 1():Appendix 1L.
2001: Tabor S; Struhl K; Scharf S J; Gelfand D H
DNA-dependent DNA polymerases.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2001;Chapter 3():Unit3.5.
2001: Struhl K
Reagents and radioisotopes used to manipulate nucleic acids.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2001;Chapter 3():Unit3.4.
2001: Struhl K
Subcloning of DNA fragments.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2001;Chapter 3():Unit3.16.
2001: Struhl K
Ribonucleases.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2001;Chapter 3():Unit3.13.
2001: Tabor S; Struhl K
Endonucleases.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2001;Chapter 3():Unit3.12.
2001: Struhl K
Analysis of DNA-protein interactions using proteins synthesized in vitro from cloned genes.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2001;Chapter 12():Unit 12.9.
2001: Struhl K
Synthesizing proteins in vitro by transcription and translation of cloned genes.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2001;Chapter 10():Unit 10.17.
2001: Lee M; Struhl K
Multiple functions of the nonconserved N-terminal domain of yeast TATA-binding protein.
Genetics 2001;158(1):87-93.
2001: Geisberg J V; Holstege F C; Young R A; Struhl K
Yeast NC2 associates with the RNA polymerase II preinitiation complex and selectively affects transcription in vivo.
Molecular and cellular biology 2001;21(8):2736-42.
2001: Deckert J; Struhl K
Histone acetylation at promoters is differentially affected by specific activators and repressors.
Molecular and cellular biology 2001;21(8):2726-35.
2001: Mencía M; Struhl K
Region of yeast TAF 130 required for TFIID to associate with promoters.
Molecular and cellular biology 2001;21(4):1145-54.
2000: Kuo M H; vom Baur E; Struhl K; Allis C D
Gcn4 activator targets Gcn5 histone acetyltransferase to specific promoters independently of transcription.
Molecular cell 2000;6(6):1309-20.
2000: Reid J L; Iyer V R; Brown P O; Struhl K
Coordinate regulation of yeast ribosomal protein genes is associated with targeted recruitment of Esa1 histone acetylase.
Molecular cell 2000;6(6):1297-307.
2000: Mai X; Chou S; Struhl K
Preferential accessibility of the yeast his3 promoter is determined by a general property of the DNA sequence, not by specific elements.
Molecular and cellular biology 2000;20(18):6668-76.
2000: Lee M; Chatterjee S; Struhl K
Genetic analysis of the role of Pol II holoenzyme components in repression by the Cyc8-Tup1 corepressor in yeast.
Genetics 2000;155(4):1535-42.
2000: Dorris D R; Struhl K
Artificial recruitment of TFIID, but not RNA polymerase II holoenzyme, activates transcription in mammalian cells.
Molecular and cellular biology 2000;20(12):4350-8.
2000: Garcia-Gimeno M A; Struhl K
Aca1 and Aca2, ATF/CREB activators in Saccharomyces cerevisiae, are important for carbon source utilization but not the response to stress.
Molecular and cellular biology 2000;20(12):4340-9.
2000: Kuras L; Kosa P; Mencia M; Struhl K
TAF-Containing and TAF-independent forms of transcriptionally active TBP in vivo.
Science (New York, N.Y.) 2000;288(5469):1244-8.
2000: Stargell L A; Moqtaderi Z; Dorris D R; Ogg R C; Struhl K
TFIIA has activator-dependent and core promoter functions in vivo.
The Journal of biological chemistry 2000;275(17):12374-80.
2000: Geisberg J V; Struhl K
TATA-binding protein mutants that increase transcription from enhancerless and repressed promoters in vivo.
Molecular and cellular biology 2000;20(5):1478-88.
1999: Chou S; Chatterjee S; Lee M; Struhl K
Transcriptional activation in yeast cells lacking transcription factor IIA.
Genetics 1999;153(4):1573-81.
1999: Struhl K
Fundamentally different logic of gene regulation in eukaryotes and prokaryotes.
Cell 1999;98(1):1-4.
1999: Kuras L; Struhl K
Binding of TBP to promoters in vivo is stimulated by activators and requires Pol II holoenzyme.
Nature 1999;399(6736):609-13.
1999: Ranallo R T; Struhl K; Stargell L A
A TATA-binding protein mutant defective for TFIID complex formation in vivo.
Molecular and cellular biology 1999;19(6):3951-7.
1999: Keaveney M; Struhl K
Incorporation of Drosophila TAF110 into the yeast TFIID complex does not permit the Sp1 glutamine-rich activation domain to function in vivo.
Genes to cells : devoted to molecular & cellular mechanisms 1999;4(4):197-203.
1999: Gaudreau L; Keaveney M; Nevado J; Zaman Z; Bryant G O; Struhl K; Ptashne M
Transcriptional activation by artificial recruitment in yeast is influenced by promoter architecture and downstream sequences.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(6):2668-73.
1998: Van Heeckeren W J; Dorris D R; Struhl K
The mating-type proteins of fission yeast induce meiosis by directly activating mei3 transcription.
Molecular and cellular biology 1998;18(12):7317-26.
1998: Moqtaderi Z; Keaveney M; Struhl K
The histone H3-like TAF is broadly required for transcription in yeast.
Molecular cell 1998;2(5):675-82.
1998: Benson J D; Benson M; Howley P M; Struhl K
Association of distinct yeast Not2 functional domains with components of Gcn5 histone acetylase and Ccr4 transcriptional regulatory complexes.
The EMBO journal 1998;17(22):6714-22.
1998: Kadosh D; Struhl K
Targeted recruitment of the Sin3-Rpd3 histone deacetylase complex generates a highly localized domain of repressed chromatin in vivo.
Molecular and cellular biology 1998;18(9):5121-7.
1998: Struhl K; Moqtaderi Z
The TAFs in the HAT.
Cell 1998;94(1):1-4.
1998: Keaveney M; Struhl K
Activator-mediated recruitment of the RNA polymerase II machinery is the predominant mechanism for transcriptional activation in yeast.
Molecular cell 1998;1(6):917-24.
1998: Kadosh D; Struhl K
Histone deacetylase activity of Rpd3 is important for transcriptional repression in vivo.
Genes & development 1998;12(6):797-805.
1998: Struhl K
Histone acetylation and transcriptional regulatory mechanisms.
Genes & development 1998;12(5):599-606.
1998: Struhl K; Kadosh D; Keaveney M; Kuras L; Moqtaderi Z
Activation and repression mechanisms in yeast.
Cold Spring Harbor symposia on quantitative biology 1998;63():413-21.
1997: Fernandes L; Rodrigues-Pousada C; Struhl K
Yap, a novel family of eight bZIP proteins in Saccharomyces cerevisiae with distinct biological functions.
Molecular and cellular biology 1997;17(12):6982-93.
1997: Chou S; Struhl K
Transcriptional activation by TFIIB mutants that are severely impaired in interaction with promoter DNA and acidic activation domains.
Molecular and cellular biology 1997;17(12):6794-802.
1997: Kadosh D; Struhl K
Repression by Ume6 involves recruitment of a complex containing Sin3 corepressor and Rpd3 histone deacetylase to target promoters.
Cell 1997;89(3):365-71.
1997: Lee M; Struhl K
A severely defective TATA-binding protein-TFIIB interaction does not preclude transcriptional activation in vivo.
Molecular and cellular biology 1997;17(3):1336-45.
1997: Struhl K
Selective roles for TATA-binding-protein-associated factors in vivo.
Genes and function 1997;1(1):5-9.
1996: Struhl K
Transcriptional enhancement by acidic activators.
Biochimica et biophysica acta 1996;1288(3):O15-7.
1996: Moqtaderi Z; Yale J D; Struhl K; Buratowski S
Yeast homologues of higher eukaryotic TFIID subunits.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(25):14654-8.
1996: Moqtaderi Z; Bai Y; Poon D; Weil P A; Struhl K
TBP-associated factors are not generally required for transcriptional activation in yeast.
Nature 1996;383(6596):188-91.
1996: Stargell L A; Struhl K
Mechanisms of transcriptional activation in vivo: two steps forward.
Trends in genetics : TIG 1996;12(8):311-5.
1996: Stargell L A; Struhl K
A new class of activation-defective TATA-binding protein mutants: evidence for two steps of transcriptional activation in vivo.
Molecular and cellular biology 1996;16(8):4456-64.
1996: Iyer V; Struhl K
Absolute mRNA levels and transcriptional initiation rates in Saccharomyces cerevisiae.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(11):5208-12.
1996: Struhl K
Chromatin structure and RNA polymerase II connection: implications for transcription.
Cell 1996;84(2):179-82.
1995: Iyer V; Struhl K
Mechanism of differential utilization of the his3 TR and TC TATA elements.
Molecular and cellular biology 1995;15(12):7059-66.
1995: Lee M; Struhl K
Mutations on the DNA-binding surface of TATA-binding protein can specifically impair the response to acidic activators in vivo.
Molecular and cellular biology 1995;15(10):5461-9.
1995: Kim J; Struhl K
Determinants of half-site spacing preferences that distinguish AP-1 and ATF/CREB bZIP domains.
Nucleic acids research 1995;23(13):2531-7.
1995: Stargell L A; Struhl K
The TBP-TFIIA interaction in the response to acidic activators in vivo.
Science (New York, N.Y.) 1995;269(5220):75-8.
1995: Iyer V; Struhl K
Poly(dA:dT), a ubiquitous promoter element that stimulates transcription via its intrinsic DNA structure.
The EMBO journal 1995;14(11):2570-9.
1995: Chatterjee S; Struhl K
Connecting a promoter-bound protein to TBP bypasses the need for a transcriptional activation domain.
Nature 1995;374(6525):820-2.
1995: Tzamarias D; Struhl K
Distinct TPR motifs of Cyc8 are involved in recruiting the Cyc8-Tup1 corepressor complex to differentially regulated promoters.
Genes & development 1995;9(7):821-31.
1994: Klein C; Struhl K
Increased recruitment of TATA-binding protein to the promoter by transcriptional activation domains in vivo.
Science (New York, N.Y.) 1994;266(5183):280-2.
1994: Arndt K M; Wobbe C R; Ricupero-Hovasse S; Struhl K; Winston F
Equivalent mutations in the two repeats of yeast TATA-binding protein confer distinct TATA recognition specificities.
Molecular and cellular biology 1994;14(6):3719-28.
1994: Tzamarias D; Struhl K
Functional dissection of the yeast Cyc8-Tup1 transcriptional co-repressor complex.
Nature 1994;369(6483):758-61.
1994: Cormack B P; Strubin M; Stargell L A; Struhl K
Conserved and nonconserved functions of the yeast and human TATA-binding proteins.
Genes & development 1994;8(11):1335-43.
1994: Klein C; Struhl K
Protein kinase A mediates growth-regulated expression of yeast ribosomal protein genes by modulating RAP1 transcriptional activity.
Molecular and cellular biology 1994;14(3):1920-8.
1994: Collart M A; Struhl K
NOT1(CDC39), NOT2(CDC36), NOT3, and NOT4 encode a global-negative regulator of transcription that differentially affects TATA-element utilization.
Genes & development 1994;8(5):525-37.
1994: Struhl K
Duality of TBP, the universal transcription factor.
Science (New York, N.Y.) 1994;263(5150):1103-4.
1993: Cormack B P; Struhl K
Regional codon randomization: defining a TATA-binding protein surface required for RNA polymerase III transcription.
Science (New York, N.Y.) 1993;262(5131):244-8.
1993: Pu W T; Struhl K
Dimerization of leucine zippers analyzed by random selection.
Nucleic acids research 1993;21(18):4348-55.
1993: Kim J; Tzamarias D; Ellenberger T; Harrison S C; Struhl K
Adaptability at the protein-DNA interface is an important aspect of sequence recognition by bZIP proteins.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(10):4513-7.
1993: Collart M A; Struhl K
CDC39, an essential nuclear protein that negatively regulates transcription and differentially affects the constitutive and inducible HIS3 promoters.
The EMBO journal 1993;12(1):177-86.
1992: Vincent A C; Struhl K
ACR1, a yeast ATF/CREB repressor.
Molecular and cellular biology 1992;12(12):5394-405.
1992: Oliviero S; Robinson G S; Struhl K; Spiegelman B M
Yeast GCN4 as a probe for oncogenesis by AP-1 transcription factors: transcriptional activation through AP-1 sites is not sufficient for cellular transformation.
Genes & development 1992;6(9):1799-809.
1992: van Heeckeren W J; Sellers J W; Struhl K
Role of the conserved leucines in the leucine zipper dimerization motif of yeast GCN4.
Nucleic acids research 1992;20(14):3721-4.
1992: Cormack B P; Struhl K
The TATA-binding protein is required for transcription by all three nuclear RNA polymerases in yeast cells.
Cell 1992;69(4):685-96.
1992: Tzamarias D; Pu W T; Struhl K
Mutations in the bZIP domain of yeast GCN4 that alter DNA-binding specificity.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(6):2007-11.
1992: Strubin M; Struhl K
Yeast and human TFIID with altered DNA-binding specificity for TATA elements.
Cell 1992;68(4):721-30.
1992: Pu W T; Struhl K
Uracil interference, a rapid and general method for defining protein-DNA interactions involving the 5-methyl group of thymines: the GCN4-DNA complex.
Nucleic acids research 1992;20(4):771-5.
1991: Pu W T; Struhl K
Highly conserved residues in the bZIP domain of yeast GCN4 are not essential for DNA binding.
Molecular and cellular biology 1991;11(10):4918-26.
1991: Pu W T; Struhl K
The leucine zipper symmetrically positions the adjacent basic regions for specific DNA binding.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(16):6901-5.
1991: Cormack B P; Strubin M; Ponticelli A S; Struhl K
Functional differences between yeast and human TFIID are localized to the highly conserved region.
Cell 1991;65(2):341-8.
1991: Oliviero S; Struhl K
Synergistic transcriptional enhancement does not depend on the number of acidic activation domains bound to the promoter.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(1):224-8.
1990: Sellers J W; Vincent A C; Struhl K
Mutations that define the optimal half-site for binding yeast GCN4 activator protein and identify an ATF/CREB-like repressor that recognizes similar DNA sites.
Molecular and cellular biology 1990;10(10):5077-86.
1990: Weiss M A; Ellenberger T; Wobbe C R; Lee J P; Harrison S C; Struhl K
Folding transition in the DNA-binding domain of GCN4 on specific binding to DNA.
Nature 1990;347(6293):575-8.
1990: Mahadevan S; Struhl K
Tc, an unusual promoter element required for constitutive transcription of the yeast HIS3 gene.
Molecular and cellular biology 1990;10(9):4447-55.
1990: Brandl C J; Struhl K
A nucleosome-positioning sequence is required for GCN4 to activate transcription in the absence of a TATA element.
Molecular and cellular biology 1990;10(8):4256-65.
1990: Wobbe C R; Struhl K
Yeast and human TATA-binding proteins have nearly identical DNA sequence requirements for transcription in vitro.
Molecular and cellular biology 1990;10(8):3859-67.
1990: Ponticelli A S; Struhl K
Analysis of Saccharomyces cerevisiae his3 transcription in vitro: biochemical support for multiple mechanisms of transcription.
Molecular and cellular biology 1990;10(6):2832-9.
1990: Singer V L; Wobbe C R; Struhl K
A wide variety of DNA sequences can functionally replace a yeast TATA element for transcriptional activation.
Genes & development 1990;4(4):636-45.
1989: Oliphant A R; Struhl K
An efficient method for generating proteins with altered enzymatic properties: application to beta-lactamase.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(23):9094-8.
1989: Harbury P A; Struhl K
Functional distinctions between yeast TATA elements.
Molecular and cellular biology 1989;9(12):5298-304.
1989: Sellers J W; Struhl K
Changing fos oncoprotein to a jun-independent DNA binding protein with GCN4 dimerization specificity by swapping "leucine zippers".
Nature 1989;341(6237):74-6.
1989: Oliphant A R; Brandl C J; Struhl K
Defining the sequence specificity of DNA-binding proteins by selecting binding sites from random-sequence oligonucleotides: analysis of yeast GCN4 protein.
Molecular and cellular biology 1989;9(7):2944-9.
1989: Brandl C J; Struhl K
Yeast GCN4 transcriptional activator protein interacts with RNA polymerase II in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(8):2652-6.
1989: Chen W; Struhl K
Yeast upstream activator protein GCN4 can stimulate transcription when its binding site replaces the TATA element.
The EMBO journal 1989;8(1):261-8.
1988: Hill D E; Struhl K
Molecular characterization of GCD1, a yeast gene required for general control of amino acid biosynthesis and cell-cycle initiation.
Nucleic acids research 1988;16(19):9253-65.
1988: Oliphant A R; Struhl K
Defining the consensus sequences of E.coli promoter elements by random selection.
Nucleic acids research 1988;16(15):7673-83.
1988: Hope I A; Mahadevan S; Struhl K
Structural and functional characterization of the short acidic transcriptional activation region of yeast GCN4 protein.
Nature 1988;333(6174):635-40.
1988: Chen W; Struhl K
Saturation mutagenesis of a yeast his3 "TATA element": genetic evidence for a specific TATA-binding protein.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(8):2691-5.
1988: Struhl K
The JUN oncoprotein, a vertebrate transcription factor, activates transcription in yeast.
Nature 1988;332(6165):649-50.
1988: Kanazawa S; Driscoll M; Struhl K
ATR1, a Saccharomyces cerevisiae gene encoding a transmembrane protein required for aminotriazole resistance.
Molecular and cellular biology 1988;8(2):664-73.
1988: Struhl K; Brandl C J; Chen W; Harbury P A; Hope I A; Mahadevan S
Transcriptional activation by yeast GCN4, a functional homolog to the jun oncoprotein.
Cold Spring Harbor symposia on quantitative biology 1988;53 Pt 2():701-9.
1987: Hope I A; Struhl K
GCN4, a eukaryotic transcriptional activator protein, binds as a dimer to target DNA.
The EMBO journal 1987;6(9):2781-4.

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