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Kevin Struhl

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Saccharomyces cerevisiae

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Kevin Struhl; Eran Segal
Determinants of nucleosome positioning.
Heather A Hirsch; Dimitrios Iliopoulos; Kevin Struhl
Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth.
Benoit Miotto; Kevin Struhl
JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress.

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All Publications

2013: Kevin Struhl; Eran Segal
Determinants of nucleosome positioning.
Nature structural & molecular biology 2013;20(3):267-73.
2013: Heather A Hirsch; Dimitrios Iliopoulos; Kevin Struhl
Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(3):972-7.
2011: Benoit Miotto; Kevin Struhl
JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress.
Molecular cell 2011;44(1):62-71.
2011: Christos Polytarchou; Kevin Struhl; Maria Hatziapostolou; Dimitrios Iliopoulos; Filippos Kottakis; Ioanna Maroulakou; Philip N Tsichlis
Akt2 regulates all Akt isoforms and promotes resistance to hypoxia through induction of miR-21 upon oxygen deprivation.
Cancer research 2011;71(13):4720-31.
2011: Dimitrios Iliopoulos; Heather A Hirsch; Kevin Struhl
Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types.
Cancer research 2011;71(9):3196-201.
2011: Dimitrios Iliopoulos; Heather A Hirsch; Guannan Wang; Kevin Struhl
Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(4):1397-402.
2011: Yael Katan-Khaykovich; Kevin Struhl
Splitting of H3-H4 tetramers at transcriptionally active genes undergoing dynamic histone exchange.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(4):1296-301.
2010: George Locke; Denis Tolkunov; Zarmik Moqtaderi; Kevin Struhl; Alexandre V Morozov
High-throughput sequencing reveals a simple model of nucleosome energetics.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(49):20998-1003.
2010: Xiaochun Fan; Zarmik Moqtaderi; Yi jin; Yong Zhang; X Shirley Liu; Kevin Struhl
Nucleosome depletion at yeast terminators is not intrinsic and can occur by a transcriptional mechanism linked to 3'-end formation.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(42):17945-50.
2010: Dimitrios Iliopoulos; Marianne Lindahl-Allen; Christos Polytarchou; Heather A Hirsch; Philip Tsichlis; Kevin Struhl
Loss of miR-200 inhibition of Suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells.
Molecular cell 2010;39(5):761-72.
2010: Dimitrios Iliopoulos; Savina A Jaeger; Heather A Hirsch; Martha L Bulyk; Kevin Struhl
STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer.
Molecular cell 2010;39(4):493-506.
2010: Zarmik Moqtaderi; Jie Wang; Debasish Raha; Robert J White; Michael Snyder; Zhiping Weng; Kevin Struhl
Genomic binding profiles of functionally distinct RNA polymerase III transcription complexes in human cells.
Nature structural & molecular biology 2010;17(5):635-40.
2010: Heather A Hirsch; Dimitrios Iliopoulos; Amita Joshi; Yong Zhang; Savina A Jaeger; Martha Bulyk; Philip Tsichlis; X Shirley Liu; Kevin Struhl
A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases.
Cancer cell 2010;17(4):348-61.
2010: Debasish Raha; Zhong Wang; Zarmik Moqtaderi; Linfeng Wu; Guoneng Zhong; Mark Gerstein; Kevin Struhl; Michael Snyder
Close association of RNA polymerase II and many transcription factors with Pol III genes.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(8):3639-44.
2010: Benoit Miotto; Kevin Struhl
HBO1 histone acetylase activity is essential for DNA replication licensing and inhibited by Geminin.
Molecular cell 2010;37(1):57-66.
2010: Annie Yang; Zhou Zhu; Arminja Kettenbach; Philipp Kapranov; Frank McKeon; Thomas Gingeras; Kevin Struhl
Genome-wide mapping indicates that p73 and p63 co-occupy target sites and have similar dna-binding profiles in vivo.
PloS one 2010;5(7):e11572.
2009: Dimitrios Iliopoulos; Heather A Hirsch; Kevin Struhl
An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation.
Cell 2009;139(4):693-706.
2009: Heather A Hirsch; Dimitrios Iliopoulos; Philip N Tsichlis; Kevin Struhl
Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission.
Cancer research 2009;69(19):7507-11.
2009: Raymond K Auerbach; Ghia Euskirchen; Joel Rozowsky; Nathan Lamarre-Vincent; Zarmik Moqtaderi; Philippe Lefrançois; Kevin Struhl; Mark Gerstein; Michael Snyder
Mapping accessible chromatin regions using Sono-Seq.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(35):14926-31.
2009: Yong Zhang; Zarmik Moqtaderi; Barbara P Rattner; Ghia Euskirchen; Michael Snyder; James T Kadonaga; X Shirley Liu; Kevin Struhl
Intrinsic histone-DNA interactions are not the major determinant of nucleosome positions in vivo.
Nature structural & molecular biology 2009;16(8):847-52.
2009: Dimitrios Iliopoulos; Christos Polytarchou; Maria Hatziapostolou; Filippos Kottakis; Ioanna G Maroulakou; Kevin Struhl; Philip Tsichlis
MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells.
Science signaling 2009;2(92):ra62.
2009: Xiaochun Fan; Kevin Struhl
Where does mediator bind in vivo?
PloS one 2009;4(4):e5029.
2008: Xiaochun Fan; Nathan Lamarre-Vincent; Qian Wang; Kevin Struhl
Extensive chromatin fragmentation improves enrichment of protein binding sites in chromatin immunoprecipitation experiments.
Nucleic acids research 2008;36(19):e125.
2008: Hiten D Madhani; Nicole J Francis; Robert E Kingston; Roger D Kornberg; Danesh Moazed; Geeta J Narlikar; Barbara Panning; Kevin Struhl
Epigenomics: a roadmap, but to where?
Science (New York, N.Y.) 2008;322(5898):43-4.
2008: Kevin Struhl
The hisB463 mutation and expression of a eukaryotic protein in Escherichia coli.
Genetics 2008;180(2):709-14.
2008: Benoit Miotto; Kevin Struhl
HBO1 histone acetylase is a coactivator of the replication licensing factor Cdt1.
Genes & development 2008;22(19):2633-8.
2008: jitendra thakur; Haribabu Arthanari; Fajun Yang; Shih-Jung Pan; Xiaochun Fan; Julia Breger; Dominique Frueh; Kailash Gulshan; Darrick K Li; Eleftherios Mylonakis; Kevin Struhl; W Scott Moye-Rowley; Brendan P Cormack; Gerhard Wagner; Anders M Näär
A nuclear receptor-like pathway regulating multidrug resistance in fungi.
Nature 2008;452(7187):604-9.
2008: Zarmik Moqtaderi; Kevin Struhl
Expanding the repertoire of plasmids for PCR-mediated epitope tagging in yeast.
Yeast (Chichester, England) 2008;25(4):287-92.
2008: Joseph T Wade; Kevin Struhl
The transition from transcriptional initiation to elongation.
Current opinion in genetics & development 2008;18(2):130-6.
2008: Kevin Struhl
Kevin Struhl. Interview.
Current biology : CB 2008;18(1):R7-9.
2007: Marc A Schwabish; Kevin Struhl
The Swi/Snf complex is important for histone eviction during transcriptional activation and RNA polymerase II elongation in vivo.
Molecular and cellular biology 2007;27(20):6987-95.
2007: Benoit Miotto; Kevin Struhl
[Histone H4 lysine 16 acetylation: from genome regulation to tumoral progression].
Médecine sciences : M/S 2007;23(8-9):735-40.
2007: Joseph T Wade; Kevin Struhl; Stephen J W Busby; David C Grainger
Genomic analysis of protein-DNA interactions in bacteria: insights into transcription and chromosome organization.
Molecular microbiology 2007;65(1):21-6.
2007: Kevin Struhl
Transcriptional noise and the fidelity of initiation by RNA polymerase II.
Nature structural & molecular biology 2007;14(2):103-5.
2007: Srinka Ghosh; Heather A. Hirsch; Edward A Sekinger; Philipp Kapranov; Kevin Struhl; Thomas Gingeras
Differential analysis for high density tiling microarray data.
BMC bioinformatics 2007;8():359.
2006: Nikos B Reppas; Joseph T Wade; George M Church; Kevin Struhl
The transition between transcriptional initiation and elongation in E. coli is highly variable and often rate limiting.
Molecular cell 2006;24(5):747-57.
2006: Annie Yang; Zhou Zhu; Philipp Kapranov; Frank McKeon; George M Church; Thomas Gingeras; Kevin Struhl
Relationships between p63 binding, DNA sequence, transcription activity, and biological function in human cells.
Molecular cell 2006;24(4):593-602.
2006: Amparo Pascual-Ahuir; Kevin Struhl; Markus Proft
Genome-wide location analysis of the stress-activated MAP kinase Hog1 in yeast.
Methods (San Diego, Calif.) 2006;40(3):272-8.
2006: Joseph T Wade; David C Grainger; Douglas Hurd; Stephen J W Busby; Kevin Struhl; Daniel Castro Roa; Evgeny Nudler
Extensive functional overlap between sigma factors in Escherichia coli.
Nature structural & molecular biology 2006;13(9):806-14.
2006: Benoit Miotto; Kevin Struhl
Differential gene regulation by selective association of transcriptional coactivators and bZIP DNA-binding domains.
Molecular and cellular biology 2006;26(16):5969-82.
2006: Markus Proft; Glòria Mas; Eulàlia de Nadal; Alexandre Vendrell; Núria Noriega; Kevin Struhl; Francesc Posas
The stress-activated Hog1 kinase is a selective transcriptional elongation factor for genes responding to osmotic stress.
Molecular cell 2006;23(2):241-50.
2006: Marc A Schwabish; Kevin Struhl
Asf1 mediates histone eviction and deposition during elongation by RNA polymerase II.
Molecular cell 2006;22(3):415-22.
2006: Daniel B Hall; Joseph T Wade; Kevin Struhl
An HMG protein, Hmo1, associates with promoters of many ribosomal protein genes and throughout the rRNA gene locus in Saccharomyces cerevisiae.
Molecular and cellular biology 2006;26(9):3672-9.
2006: Xiaochun Fan; Danny M Chou; Kevin Struhl
Activator-specific recruitment of Mediator in vivo.
Nature structural & molecular biology 2006;13(2):117-20.
2006: Srinka Ghosh; Heather A. Hirsch; Edward A Sekinger; Kevin Struhl; Thomas Gingeras
Rank-statistics based enrichment-site prediction algorithm developed for chromatin immunoprecipitation on chip experiments.
BMC bioinformatics 2006;7():434.
2005: Amita A Joshi; Kevin Struhl
Eaf3 chromodomain interaction with methylated H3-K36 links histone deacetylation to Pol II elongation.
Molecular cell 2005;20(6):971-8.
2005: Joseph T Wade; Nikos B Reppas; George M Church; Kevin Struhl
Genomic analysis of LexA binding reveals the permissive nature of the Escherichia coli genome and identifies unconventional target sites.
Genes & development 2005;19(21):2619-30.
2005: Markus Proft; Frank Gibbons; Matthew Copeland; Frederick P Roth; Kevin Struhl
Genomewide identification of Sko1 target promoters reveals a regulatory network that operates in response to osmotic stress in Saccharomyces cerevisiae.
Eukaryotic cell 2005;4(8):1343-52.
2005: Yael Katan-Khaykovich; Kevin Struhl
Heterochromatin formation involves changes in histone modifications over multiple cell generations.
The EMBO journal 2005;24(12):2138-49.
2005: Edward A Sekinger; Zarmik Moqtaderi; Kevin Struhl
Intrinsic histone-DNA interactions and low nucleosome density are important for preferential accessibility of promoter regions in yeast.
Molecular cell 2005;18(6):735-48.
2005: Joseph V Geisberg; Kevin Struhl
Analysis of protein co-occupancy by quantitative sequential chromatin immunoprecipitation.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2005;Chapter 21():Unit 21.8.
2005: Paul B Mason; Kevin Struhl
Distinction and relationship between elongation rate and processivity of RNA polymerase II in vivo.
Molecular cell 2005;17(6):831-40.
2005: Kevin Struhl
Transcriptional activation: mediator can act after preinitiation complex formation.
Molecular cell 2005;17(6):752-4.
2005: Oscar Aparicio; Joseph V Geisberg; Edward A Sekinger; Annie Yang; Zarmik Moqtaderi; Kevin Struhl
Chromatin immunoprecipitation for determining the association of proteins with specific genomic sequences in vivo.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2005;Chapter 21():Unit 21.3.
2005: Frank Gibbons; Markus Proft; Kevin Struhl; Frederick P Roth
Chipper: discovering transcription-factor targets from chromatin immunoprecipitation microarrays using variance stabilization.
Genome biology 2005;6(11):R96.
2004: Joseph T Wade; Daniel B Hall; Kevin Struhl
The transcription factor Ifh1 is a key regulator of yeast ribosomal protein genes.
Nature 2004;432(7020):1054-8.
2004: Joseph T Wade; Kevin Struhl
Association of RNA polymerase with transcribed regions in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(51):17777-82.
2004: Marc A Schwabish; Kevin Struhl
Evidence for eviction and rapid deposition of histones upon transcriptional elongation by RNA polymerase II.
Molecular and cellular biology 2004;24(23):10111-7.
2004: Zarmik Moqtaderi; Kevin Struhl
Defining in vivo targets of nuclear proteins by chromatin immunoprecipitation and microarray analysis.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2004;Chapter 21():Unit 21.9.
2004: David C Grainger; Tim W Overton; Nikos Reppas; Joseph T Wade; Eiji Tamai; Jon Hobman; Chrystala Constantinidou; Kevin Struhl; George M Church; Stephen J W Busby
Genomic studies with Escherichia coli MelR protein: applications of chromatin immunoprecipitation and microarrays.
Journal of bacteriology 2004;186(20):6938-43.
2004: Oscar Aparicio; Joseph V Geisberg; Kevin Struhl
Chromatin immunoprecipitation for determining the association of proteins with specific genomic sequences in vivo.
Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.] 2004;Chapter 17():Unit 17.7.
2004: Markus Proft; Kevin Struhl
MAP kinase-mediated stress relief that precedes and regulates the timing of transcriptional induction.
Cell 2004;118(3):351-61.
2004: Joseph V Geisberg; Kevin Struhl
Cellular stress alters the transcriptional properties of promoter-bound Mot1-TBP complexes.
Molecular cell 2004;14(4):479-89.
2004: Zarmik Moqtaderi; Kevin Struhl
Genome-wide occupancy profile of the RNA polymerase III machinery in Saccharomyces cerevisiae reveals loci with incomplete transcription complexes.
Molecular and cellular biology 2004;24(10):4118-27.
2004: Simon Cawley; Stefan Bekiranov; Huck-Hui Ng; Philipp Kapranov; Edward A Sekinger; Dione Kampa; Antonio Piccolboni; Victor Sementchenko; Jill Cheng; Alan J Williams; Raymond Wheeler; Brant Wong; Jorg Drenkow; Mark Yamanaka; Sandeep Patel; Shane Brubaker; Hari Tammana; Gregg Helt; Kevin Struhl; Thomas Gingeras
Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs.
Cell 2004;116(4):499-509.
2004: Joseph V Geisberg; Kevin Struhl
Quantitative sequential chromatin immunoprecipitation, a method for analyzing co-occupancy of proteins at genomic regions in vivo.
Nucleic acids research 2004;32(19):e151.
2004: Juliet L Reid; Zarmik Moqtaderi; Kevin Struhl
Eaf3 regulates the global pattern of histone acetylation in Saccharomyces cerevisiae.
Molecular and cellular biology 2004;24(2):757-64.
2003: Paul B Mason; Kevin Struhl
The FACT complex travels with elongating RNA polymerase II and is important for the fidelity of transcriptional initiation in vivo.
Molecular and cellular biology 2003;23(22):8323-33.
2003: Huck-Hui Ng; Sudhanshu Dole; Kevin Struhl
The Rtf1 component of the Paf1 transcriptional elongation complex is required for ubiquitination of histone H2B.
The Journal of biological chemistry 2003;278(36):33625-8.
2003: Huck-Hui Ng; François Robert; Richard A Young; Kevin Struhl
Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity.
Molecular cell 2003;11(3):709-19.
2003: Huck-Hui Ng; David N Ciccone; Katrina B Morshead; Marjorie A Oettinger; Kevin Struhl
Lysine-79 of histone H3 is hypomethylated at silenced loci in yeast and mammalian cells: a potential mechanism for position-effect variegation.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(4):1820-5.
2002: Joseph V Geisberg; Zarmik Moqtaderi; Laurent Kuras; Kevin Struhl
Mot1 associates with transcriptionally active promoters and inhibits association of NC2 in Saccharomyces cerevisiae.
Molecular and cellular biology 2002;22(23):8122-34.
2002: Daniel B Hall; Kevin Struhl
The VP16 activation domain interacts with multiple transcriptional components as determined by protein-protein cross-linking in vivo.
The Journal of biological chemistry 2002;277(48):46043-50.
2002: Huck-Hui Ng; Rui-Ming Xu; Yi Zhang; Kevin Struhl
Ubiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3 lysine 79.
The Journal of biological chemistry 2002;277(38):34655-7.
2002: Jutta Deckert; Kevin Struhl
Targeted recruitment of Rpd3 histone deacetylase represses transcription by inhibiting recruitment of Swi/Snf, SAGA, and TATA binding protein.
Molecular and cellular biology 2002;22(18):6458-70.
2002: Qin Feng; Hengbin Wang; Huck-Hui Ng; Hediye Erdjument-Bromage; Paul Tempst; Kevin Struhl; Yi Zhang
Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain.
Current biology : CB 2002;12(12):1052-8.
2002: Huck-Hui Ng; Qin Feng; Hengbin Wang; Hediye Erdjument-Bromage; Paul Tempst; Yi Zhang; Kevin Struhl
Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association.
Genes & development 2002;16(12):1518-27.
2002: Markus Proft; Kevin Struhl
Hog1 kinase converts the Sko1-Cyc8-Tup1 repressor complex into an activator that recruits SAGA and SWI/SNF in response to osmotic stress.
Molecular cell 2002;9(6):1307-17.
2002: Mario Mencía; Zarmik Moqtaderi; Joseph V Geisberg; Laurent Kuras; Kevin Struhl
Activator-specific recruitment of TFIID and regulation of ribosomal protein genes in yeast.
Molecular cell 2002;9(4):823-33.
2002: Huck-Hui Ng; François Robert; Richard A Young; Kevin Struhl
Genome-wide location and regulated recruitment of the RSC nucleosome-remodeling complex.
Genes & development 2002;16(7):806-19.
2002: Yael Katan-Khaykovich; Kevin Struhl
Dynamics of global histone acetylation and deacetylation in vivo: rapid restoration of normal histone acetylation status upon removal of activators and repressors.
Genes & development 2002;16(6):743-52.
2001: Kevin Struhl
Gene regulation. A paradigm for precision.
Science (New York, N.Y.) 2001;293(5532):1054-5.
2001: D Kulish; Kevin Struhl
TFIIS enhances transcriptional elongation through an artificial arrest site in vivo.
Molecular and cellular biology 2001;21(13):4162-8.
2001: Kevin Struhl
Reagents and radioisotopes used to manipulate nucleic acids.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2001;Chapter 10():Unit 10.9.
2001: C E Seidman; Kevin Struhl
Introduction of plasmid DNA into cells.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2001;Appendix 4():4D.
2001: C E Seidman; Kevin Struhl
Introduction of plasmid DNA into cells.
Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.] 2001;Appendix 1():Appendix 1L.
2001: Stanley Tabor; Kevin Struhl; Stephen Scharf; D H Gelfand
DNA-dependent DNA polymerases.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2001;Chapter 3():Unit3.5.
2001: Kevin Struhl
Reagents and radioisotopes used to manipulate nucleic acids.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2001;Chapter 3():Unit3.4.
2001: Kevin Struhl
Subcloning of DNA fragments.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2001;Chapter 3():Unit3.16.
2001: Kevin Struhl
Ribonucleases.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2001;Chapter 3():Unit3.13.
2001: Stanley Tabor; Kevin Struhl
Endonucleases.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2001;Chapter 3():Unit3.12.
2001: Kevin Struhl
Analysis of DNA-protein interactions using proteins synthesized in vitro from cloned genes.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2001;Chapter 12():Unit 12.9.
2001: Kevin Struhl
Synthesizing proteins in vitro by transcription and translation of cloned genes.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2001;Chapter 10():Unit 10.17.
2001: M Lee; Kevin Struhl
Multiple functions of the nonconserved N-terminal domain of yeast TATA-binding protein.
Genetics 2001;158(1):87-93.
2001: Joseph V Geisberg; F C Holstege; Richard A Young; Kevin Struhl
Yeast NC2 associates with the RNA polymerase II preinitiation complex and selectively affects transcription in vivo.
Molecular and cellular biology 2001;21(8):2736-42.
2001: J Deckert; Kevin Struhl
Histone acetylation at promoters is differentially affected by specific activators and repressors.
Molecular and cellular biology 2001;21(8):2726-35.
2001: M Mencía; Kevin Struhl
Region of yeast TAF 130 required for TFIID to associate with promoters.
Molecular and cellular biology 2001;21(4):1145-54.
2000: Min-Hao Kuo; E vom Baur; Kevin Struhl; C David Allis
Gcn4 activator targets Gcn5 histone acetyltransferase to specific promoters independently of transcription.
Molecular cell 2000;6(6):1309-20.
2000: J L Reid; V R Iyer; P O Brown; Kevin Struhl
Coordinate regulation of yeast ribosomal protein genes is associated with targeted recruitment of Esa1 histone acetylase.
Molecular cell 2000;6(6):1297-307.
2000: X Mai; S Chou; Kevin Struhl
Preferential accessibility of the yeast his3 promoter is determined by a general property of the DNA sequence, not by specific elements.
Molecular and cellular biology 2000;20(18):6668-76.
2000: M Lee; S Chatterjee; Kevin Struhl
Genetic analysis of the role of Pol II holoenzyme components in repression by the Cyc8-Tup1 corepressor in yeast.
Genetics 2000;155(4):1535-42.
2000: DR Dorris; Kevin Struhl
Artificial recruitment of TFIID, but not RNA polymerase II holoenzyme, activates transcription in mammalian cells.
Molecular and cellular biology 2000;20(12):4350-8.
2000: M A Garcia-Gimeno; Kevin Struhl
Aca1 and Aca2, ATF/CREB activators in Saccharomyces cerevisiae, are important for carbon source utilization but not the response to stress.
Molecular and cellular biology 2000;20(12):4340-9.
2000: Laurent Kuras; P Kosa; M Mencia; Kevin Struhl
TAF-Containing and TAF-independent forms of transcriptionally active TBP in vivo.
Science (New York, N.Y.) 2000;288(5469):1244-8.
2000: Laurie A Stargell; Zarmik Moqtaderi; DR Dorris; RC Ogg; Kevin Struhl
TFIIA has activator-dependent and core promoter functions in vivo.
The Journal of biological chemistry 2000;275(17):12374-80.
2000: Joseph V Geisberg; Kevin Struhl
TATA-binding protein mutants that increase transcription from enhancerless and repressed promoters in vivo.
Molecular and cellular biology 2000;20(5):1478-88.
1999: S Chou; S Chatterjee; M Lee; Kevin Struhl
Transcriptional activation in yeast cells lacking transcription factor IIA.
Genetics 1999;153(4):1573-81.
1999: Kevin Struhl
Fundamentally different logic of gene regulation in eukaryotes and prokaryotes.
Cell 1999;98(1):1-4.
1999: Laurent Kuras; Kevin Struhl
Binding of TBP to promoters in vivo is stimulated by activators and requires Pol II holoenzyme.
Nature 1999;399(6736):609-13.
1999: RT Ranallo; Kevin Struhl; Laurie A Stargell
A TATA-binding protein mutant defective for TFIID complex formation in vivo.
Molecular and cellular biology 1999;19(6):3951-7.
1999: M Keaveney; Kevin Struhl
Incorporation of Drosophila TAF110 into the yeast TFIID complex does not permit the Sp1 glutamine-rich activation domain to function in vivo.
Genes to cells : devoted to molecular & cellular mechanisms 1999;4(4):197-203.
1999: L Gaudreau; M Keaveney; Julian Nevado; Zafar Zaman; G O Bryant; Kevin Struhl; Mark Ptashne
Transcriptional activation by artificial recruitment in yeast is influenced by promoter architecture and downstream sequences.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(6):2668-73.
1998: W J Van Heeckeren; DR Dorris; Kevin Struhl
The mating-type proteins of fission yeast induce meiosis by directly activating mei3 transcription.
Molecular and cellular biology 1998;18(12):7317-26.
1998: JD Benson; Mark R Benson; Peter M Howley; Kevin Struhl
Association of distinct yeast Not2 functional domains with components of Gcn5 histone acetylase and Ccr4 transcriptional regulatory complexes.
The EMBO journal 1998;17(22):6714-22.
1998: Zarmik Moqtaderi; M Keaveney; Kevin Struhl
The histone H3-like TAF is broadly required for transcription in yeast.
Molecular cell 1998;2(5):675-82.
1998: David Kadosh; Kevin Struhl
Targeted recruitment of the Sin3-Rpd3 histone deacetylase complex generates a highly localized domain of repressed chromatin in vivo.
Molecular and cellular biology 1998;18(9):5121-7.
1998: Kevin Struhl; Zarmik Moqtaderi
The TAFs in the HAT.
Cell 1998;94(1):1-4.
1998: M Keaveney; Kevin Struhl
Activator-mediated recruitment of the RNA polymerase II machinery is the predominant mechanism for transcriptional activation in yeast.
Molecular cell 1998;1(6):917-24.
1998: David Kadosh; Kevin Struhl
Histone deacetylase activity of Rpd3 is important for transcriptional repression in vivo.
Genes & development 1998;12(6):797-805.
1998: Kevin Struhl
Histone acetylation and transcriptional regulatory mechanisms.
Genes & development 1998;12(5):599-606.
1998: Kevin Struhl; David Kadosh; M Keaveney; Laurent Kuras; Zarmik Moqtaderi
Activation and repression mechanisms in yeast.
Cold Spring Harbor symposia on quantitative biology 1998;63():413-21.
1997: L Fernandes; C Rodrigues-Pousada; Kevin Struhl
Yap, a novel family of eight bZIP proteins in Saccharomyces cerevisiae with distinct biological functions.
Molecular and cellular biology 1997;17(12):6982-93.
1997: S Chou; Kevin Struhl
Transcriptional activation by TFIIB mutants that are severely impaired in interaction with promoter DNA and acidic activation domains.
Molecular and cellular biology 1997;17(12):6794-802.
1997: David Kadosh; Kevin Struhl
Repression by Ume6 involves recruitment of a complex containing Sin3 corepressor and Rpd3 histone deacetylase to target promoters.
Cell 1997;89(3):365-71.
1997: M Lee; Kevin Struhl
A severely defective TATA-binding protein-TFIIB interaction does not preclude transcriptional activation in vivo.
Molecular and cellular biology 1997;17(3):1336-45.
1997: Kevin Struhl
Selective roles for TATA-binding-protein-associated factors in vivo.
Genes and function 1997;1(1):5-9.
1996: Zarmik Moqtaderi; J D Yale; Kevin Struhl; Stephen Buratowski
Yeast homologues of higher eukaryotic TFIID subunits.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(25):14654-8.
1996: Kevin Struhl
Transcriptional enhancement by acidic activators.
Biochimica et biophysica acta 1996;1288(3):O15-7.
1996: Zarmik Moqtaderi; Y Bai; D Poon; P Anthony Weil; Kevin Struhl
TBP-associated factors are not generally required for transcriptional activation in yeast.
Nature 1996;383(6596):188-91.
1996: L A Stargell; Kevin Struhl
Mechanisms of transcriptional activation in vivo: two steps forward.
Trends in genetics : TIG 1996;12(8):311-5.
1996: L A Stargell; Kevin Struhl
A new class of activation-defective TATA-binding protein mutants: evidence for two steps of transcriptional activation in vivo.
Molecular and cellular biology 1996;16(8):4456-64.
1996: V Iyer; Kevin Struhl
Absolute mRNA levels and transcriptional initiation rates in Saccharomyces cerevisiae.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(11):5208-12.
1996: Kevin Struhl
Chromatin structure and RNA polymerase II connection: implications for transcription.
Cell 1996;84(2):179-82.
1995: V Iyer; Kevin Struhl
Mechanism of differential utilization of the his3 TR and TC TATA elements.
Molecular and cellular biology 1995;15(12):7059-66.
1995: M Lee; Kevin Struhl
Mutations on the DNA-binding surface of TATA-binding protein can specifically impair the response to acidic activators in vivo.
Molecular and cellular biology 1995;15(10):5461-9.
1995: J Kim; Kevin Struhl
Determinants of half-site spacing preferences that distinguish AP-1 and ATF/CREB bZIP domains.
Nucleic acids research 1995;23(13):2531-7.
1995: L A Stargell; Kevin Struhl
The TBP-TFIIA interaction in the response to acidic activators in vivo.
Science (New York, N.Y.) 1995;269(5220):75-8.
1995: V Iyer; Kevin Struhl
Poly(dA:dT), a ubiquitous promoter element that stimulates transcription via its intrinsic DNA structure.
The EMBO journal 1995;14(11):2570-9.
1995: S Chatterjee; Kevin Struhl
Connecting a promoter-bound protein to TBP bypasses the need for a transcriptional activation domain.
Nature 1995;374(6525):820-2.
1995: D Tzamarias; Kevin Struhl
Distinct TPR motifs of Cyc8 are involved in recruiting the Cyc8-Tup1 corepressor complex to differentially regulated promoters.
Genes & development 1995;9(7):821-31.
1994: C Klein; Kevin Struhl
Increased recruitment of TATA-binding protein to the promoter by transcriptional activation domains in vivo.
Science (New York, N.Y.) 1994;266(5183):280-2.
1994: D Tzamarias; Kevin Struhl
Functional dissection of the yeast Cyc8-Tup1 transcriptional co-repressor complex.
Nature 1994;369(6483):758-61.
1994: Karen M Arndt; C R Wobbe; S Ricupero-Hovasse; Kevin Struhl; fred winston
Equivalent mutations in the two repeats of yeast TATA-binding protein confer distinct TATA recognition specificities.
Molecular and cellular biology 1994;14(6):3719-28.
1994: Brendan P Cormack; M Strubin; L A Stargell; Kevin Struhl
Conserved and nonconserved functions of the yeast and human TATA-binding proteins.
Genes & development 1994;8(11):1335-43.
1994: C Klein; Kevin Struhl
Protein kinase A mediates growth-regulated expression of yeast ribosomal protein genes by modulating RAP1 transcriptional activity.
Molecular and cellular biology 1994;14(3):1920-8.
1994: M A Collart; Kevin Struhl
NOT1(CDC39), NOT2(CDC36), NOT3, and NOT4 encode a global-negative regulator of transcription that differentially affects TATA-element utilization.
Genes & development 1994;8(5):525-37.
1994: Kevin Struhl
Duality of TBP, the universal transcription factor.
Science (New York, N.Y.) 1994;263(5150):1103-4.
1993: Brendan P Cormack; Kevin Struhl
Regional codon randomization: defining a TATA-binding protein surface required for RNA polymerase III transcription.
Science (New York, N.Y.) 1993;262(5131):244-8.
1993: W T Pu; Kevin Struhl
Dimerization of leucine zippers analyzed by random selection.
Nucleic acids research 1993;21(18):4348-55.
1993: J Kim; D Tzamarias; Tom Ellenberger; S C Harrison; Kevin Struhl
Adaptability at the protein-DNA interface is an important aspect of sequence recognition by bZIP proteins.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(10):4513-7.
1993: M A Collart; Kevin Struhl
CDC39, an essential nuclear protein that negatively regulates transcription and differentially affects the constitutive and inducible HIS3 promoters.
The EMBO journal 1993;12(1):177-86.
1992: A C Vincent; Kevin Struhl
ACR1, a yeast ATF/CREB repressor.
Molecular and cellular biology 1992;12(12):5394-405.
1992: S Oliviero; G S Robinson; Kevin Struhl; Bruce M Spiegelman
Yeast GCN4 as a probe for oncogenesis by AP-1 transcription factors: transcriptional activation through AP-1 sites is not sufficient for cellular transformation.
Genes & development 1992;6(9):1799-809.
1992: W J van Heeckeren; J W Sellers; Kevin Struhl
Role of the conserved leucines in the leucine zipper dimerization motif of yeast GCN4.
Nucleic acids research 1992;20(14):3721-4.
1992: Brendan P Cormack; Kevin Struhl
The TATA-binding protein is required for transcription by all three nuclear RNA polymerases in yeast cells.
Cell 1992;69(4):685-96.
1992: D Tzamarias; W T Pu; Kevin Struhl
Mutations in the bZIP domain of yeast GCN4 that alter DNA-binding specificity.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(6):2007-11.
1992: W T Pu; Kevin Struhl
Uracil interference, a rapid and general method for defining protein-DNA interactions involving the 5-methyl group of thymines: the GCN4-DNA complex.
Nucleic acids research 1992;20(4):771-5.
1992: M Strubin; Kevin Struhl
Yeast and human TFIID with altered DNA-binding specificity for TATA elements.
Cell 1992;68(4):721-30.
1991: W T Pu; Kevin Struhl
Highly conserved residues in the bZIP domain of yeast GCN4 are not essential for DNA binding.
Molecular and cellular biology 1991;11(10):4918-26.
1991: W T Pu; Kevin Struhl
The leucine zipper symmetrically positions the adjacent basic regions for specific DNA binding.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(16):6901-5.
1991: Brendan P Cormack; M Strubin; A S Ponticelli; Kevin Struhl
Functional differences between yeast and human TFIID are localized to the highly conserved region.
Cell 1991;65(2):341-8.
1991: S Oliviero; Kevin Struhl
Synergistic transcriptional enhancement does not depend on the number of acidic activation domains bound to the promoter.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(1):224-8.
1990: Michael A Weiss; Tom Ellenberger; C R Wobbe; J P Lee; S C Harrison; Kevin Struhl
Folding transition in the DNA-binding domain of GCN4 on specific binding to DNA.
Nature 1990;347(6293):575-8.
1990: J W Sellers; A C Vincent; Kevin Struhl
Mutations that define the optimal half-site for binding yeast GCN4 activator protein and identify an ATF/CREB-like repressor that recognizes similar DNA sites.
Molecular and cellular biology 1990;10(10):5077-86.
1990: S Mahadevan; Kevin Struhl
Tc, an unusual promoter element required for constitutive transcription of the yeast HIS3 gene.
Molecular and cellular biology 1990;10(9):4447-55.
1990: C J Brandl; Kevin Struhl
A nucleosome-positioning sequence is required for GCN4 to activate transcription in the absence of a TATA element.
Molecular and cellular biology 1990;10(8):4256-65.
1990: C R Wobbe; Kevin Struhl
Yeast and human TATA-binding proteins have nearly identical DNA sequence requirements for transcription in vitro.
Molecular and cellular biology 1990;10(8):3859-67.
1990: A S Ponticelli; Kevin Struhl
Analysis of Saccharomyces cerevisiae his3 transcription in vitro: biochemical support for multiple mechanisms of transcription.
Molecular and cellular biology 1990;10(6):2832-9.
1990: V L Singer; C R Wobbe; Kevin Struhl
A wide variety of DNA sequences can functionally replace a yeast TATA element for transcriptional activation.
Genes & development 1990;4(4):636-45.
1989: A R Oliphant; Kevin Struhl
An efficient method for generating proteins with altered enzymatic properties: application to beta-lactamase.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(23):9094-8.
1989: P A Harbury; Kevin Struhl
Functional distinctions between yeast TATA elements.
Molecular and cellular biology 1989;9(12):5298-304.
1989: J W Sellers; Kevin Struhl
Changing fos oncoprotein to a jun-independent DNA binding protein with GCN4 dimerization specificity by swapping "leucine zippers".
Nature 1989;341(6237):74-6.
1989: A R Oliphant; C J Brandl; Kevin Struhl
Defining the sequence specificity of DNA-binding proteins by selecting binding sites from random-sequence oligonucleotides: analysis of yeast GCN4 protein.
Molecular and cellular biology 1989;9(7):2944-9.
1989: C J Brandl; Kevin Struhl
Yeast GCN4 transcriptional activator protein interacts with RNA polymerase II in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(8):2652-6.
1989: W Chen; Kevin Struhl
Yeast upstream activator protein GCN4 can stimulate transcription when its binding site replaces the TATA element.
The EMBO journal 1989;8(1):261-8.
1988: David E Hill; Kevin Struhl
Molecular characterization of GCD1, a yeast gene required for general control of amino acid biosynthesis and cell-cycle initiation.
Nucleic acids research 1988;16(19):9253-65.
1988: A R Oliphant; Kevin Struhl
Defining the consensus sequences of E.coli promoter elements by random selection.
Nucleic acids research 1988;16(15):7673-83.
1988: I A Hope; S Mahadevan; Kevin Struhl
Structural and functional characterization of the short acidic transcriptional activation region of yeast GCN4 protein.
Nature 1988;333(6174):635-40.
1988: Kevin Struhl
The JUN oncoprotein, a vertebrate transcription factor, activates transcription in yeast.
Nature 1988;332(6165):649-50.
1988: W Chen; Kevin Struhl
Saturation mutagenesis of a yeast his3 "TATA element": genetic evidence for a specific TATA-binding protein.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(8):2691-5.
1988: S Kanazawa; M Driscoll; Kevin Struhl
ATR1, a Saccharomyces cerevisiae gene encoding a transmembrane protein required for aminotriazole resistance.
Molecular and cellular biology 1988;8(2):664-73.
1988: Kevin Struhl; C J Brandl; W Chen; P A Harbury; I A Hope; S Mahadevan
Transcriptional activation by yeast GCN4, a functional homolog to the jun oncoprotein.
Cold Spring Harbor symposia on quantitative biology 1988;53 Pt 2():701-9.
1987: I A Hope; Kevin Struhl
GCN4, a eukaryotic transcriptional activator protein, binds as a dimer to target DNA.
The EMBO journal 1987;6(9):2781-4.