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Natalie Strynadka

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Neta Sal-Man; Roland Scholz; Dheva Setiaputra; Natalie C J Strynadka; Angel C Y Yu; Wanyin Deng; B Brett Finlay
EscE and EscG Are Cochaperones for the Type III Needle Protein EscF of Enteropathogenic Escherichia coli.
Martin L Ludwiczek; Jacob A Brockerman; Igor D'Angelo; Jens E Nielsen; Mark Okon; Natalie C J Strynadka; Stephen G Withers; Gary N Yalloway; Lawrence P McIntosh
Strategies for Modulating the pH-Dependent Activity of a Family 11 Glycoside Hydrolase.
Bojana Rakic; Francesco V Rao; Natalie C J Strynadka; Warren Wakarchuk; Karen Freimann; Stephen G Withers
Structure-based mutagenic analysis of mechanism and substrate specificity in mammalian glycosyltransferases: porcine ST3Gal-I.

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2013: Neta Sal-Man; Roland Scholz; Dheva Setiaputra; Natalie C J Strynadka; Angel C Y Yu; Wanyin Deng; B Brett Finlay
EscE and EscG Are Cochaperones for the Type III Needle Protein EscF of Enteropathogenic Escherichia coli.
Journal of bacteriology 2013;195(11):2481-9.
2013: Martin L Ludwiczek; Jacob A Brockerman; Igor D'Angelo; Jens E Nielsen; Mark Okon; Natalie C J Strynadka; Stephen G Withers; Gary N Yalloway; Lawrence P McIntosh
Strategies for Modulating the pH-Dependent Activity of a Family 11 Glycoside Hydrolase.
Biochemistry 2013;52(18):3138-56.
2013: Bojana Rakic; Francesco V Rao; Natalie C J Strynadka; Warren Wakarchuk; Karen Freimann; Stephen G Withers
Structure-based mutagenic analysis of mechanism and substrate specificity in mammalian glycosyltransferases: porcine ST3Gal-I.
Glycobiology 2013;23(5):536-45.
2013: Julien R C Bergeron; Frank Dimaio; Heather B Felise; Samuel I Miller; Richard A Pfuetzner; Nikolaos G Sgourakis; Marija Vuckovic; Liam J Worrall; Angel C Yu; David Baker; Natalie C J Strynadka
A Refined Model of the Prototypical Salmonella SPI-1 T3SS Basal Body Reveals the Molecular Basis for Its Assembly.
PLoS pathogens 2013;9(4):e1003307.
2012: Gerd Prehna; Nikolay Stoynov; Marija Vuckovic; B Brett Finlay; Leonard J Foster; Yuling Li; Lawrence P McIntosh; Mark Okon; Natalie C J Strynadka
The zinc regulated antivirulence pathway of Salmonella is a multiprotein immunoglobulin adhesion system.
The Journal of biological chemistry 2012;287(39):32324-37.
2012: Andrew L Lovering; Malcolm G P Page; Susan S Safadi; Franck Danel; Liza de Castro; Michael C Gretes; Natalie C J Strynadka
Structural insights into the anti-methicillin-resistant Staphylococcus aureus (MRSA) activity of ceftobiprole.
The Journal of biological chemistry 2012;287(38):32096-102.
2012: Dustin T King; Robert Gruninger; Liam J Worrall; Natalie C J Strynadka
New Delhi metallo-β-lactamase: structural insights into β-lactam recognition and inhibition.
Journal of the American Chemical Society 2012;134(28):11362-5.
2012: Gerd Prehna; Joel H Weiner; Guijin Zhang; Marek Duszyk; Xiandi Gong; Lawrence P McIntosh; Mark Okon; Natalie C J Strynadka
A protein export pathway involving Escherichia coli porins.
Structure (London, England : 1993) 2012;20(7):1154-66.
2012: Brianne J Burkinshaw; Gerd Prehna; Liam J Worrall; Natalie C J Strynadka
Structure of Salmonella effector protein SopB N-terminal domain in complex with host Rho GTPase Cdc42.
The Journal of biological chemistry 2012;287(16):13348-55.
2012: Angel C Y Yu; Liam J Worrall; Natalie C J Strynadka
Structural insight into the bacterial mucinase StcE essential to adhesion and immune evasion during enterohemorrhagic E. coli infection.
Structure (London, England : 1993) 2012;20(4):707-17.
2012: Andrew L Lovering; Susan S Safadi; Natalie C J Strynadka
Structural perspective of peptidoglycan biosynthesis and assembly.
Annual review of biochemistry 2012;81():451-78.
2011: Leo Y-C Lin; Bojana Rakic; Cecilia P C Chiu; Emilie Lameignere; Warren W Wakarchuk; Stephen G Withers; Natalie C J Strynadka
Structure and mechanism of the lipooligosaccharide sialyltransferase from Neisseria meningitidis.
The Journal of biological chemistry 2011;286(43):37237-48.
2011: Ho Jun Lee; Jamie R Rich; Luke L Lairson; Emilie Lameignere; Warren W Wakarchuk; Stephen G Withers; Natalie C J Strynadka
Structural and kinetic analysis of substrate binding to the sialyltransferase Cst-II from Campylobacter jejuni.
The Journal of biological chemistry 2011;286(41):35922-32.
2010: Mohan Babu; Jack F Greenblatt; Andrew Emili; Natalie C J Strynadka; Reinhart A F Reithmeier; Trevor F Moraes
Structure of a SLC26 anion transporter STAS domain in complex with acyl carrier protein: implications for E. coli YchM in fatty acid metabolism.
Structure (London, England : 1993) 2010;18(11):1450-62.
2010: Andrew L Lovering; Leo Y-C Lin; Edward W Sewell; Thomas Spreter; Eric D Brown; Natalie C J Strynadka
Structure of the bacterial teichoic acid polymerase TagF provides insights into membrane association and catalysis.
Nature structural & molecular biology 2010;17(5):582-9.
2010: Liam J Worrall; Marija Vuckovic; Natalie C J Strynadka
Crystal structure of the C-terminal domain of the Salmonella type III secretion system export apparatus protein InvA.
Protein science : a publication of the Protein Society 2010;19(5):1091-6.
2010: Stephan Reitinger; Ying Yu; Jacqueline Wicki; Martin Ludwiczek; Igor D'Angelo; Simon Baturin; Mark Okon; Natalie C J Strynadka; Stefan Lutz; Stephen G Withers; Lawrence P McIntosh
Circular permutation of Bacillus circulans xylanase: a kinetic and structural study.
Biochemistry 2010;49(11):2464-74.
2010: Richard A Rothery; Michela G Bertero; Thomas Spreter; Nasim Bouromand; Natalie C J Strynadka; Joel Weiner
Protein crystallography reveals a role for the FS0 cluster of Escherichia coli nitrate reductase A (NarGHI) in enzyme maturation.
The Journal of biological chemistry 2010;285(12):8801-7.
2010: Jarrod W Johnson; Michael Gretes; Valerie J Goodfellow; Laura Marrone; Miriam L Heynen; Natalie C J Strynadka; Gary I Dmitrienko
Cyclobutanone analogues of beta-lactams revisited: insights into conformational requirements for inhibition of serine- and metallo-beta-lactamases.
Journal of the American Chemical Society 2010;132(8):2558-60.
2010: Sarah Sanowar; Pragya Singh; Richard A Pfuetzner; Ingemar André; Hongjin Zheng; Thomas Spreter; Natalie C J Strynadka; Tamir Gonen; David Baker; David R Goodlett; Samuel I Miller
Interactions of the transmembrane polymeric rings of the Salmonella enterica serovar Typhimurium type III secretion system.
mBio 2010;1(3):.
2009: Patrick H W Chan; Luke L Lairson; Ho Jun Lee; Warren W Wakarchuk; Natalie C J Strynadka; Stephen G Withers; Lawrence P McIntosh
NMR spectroscopic characterization of the sialyltransferase CstII from Campylobacter jejuni: histidine 188 is the general base.
Biochemistry 2009;48(47):11220-30.
2009: Francesco V Rao; Jamie R Rich; Bojana Rakić; Sai Buddai; Marc F Schwartz; Karl Johnson; Caryn Bowe; Warren W Wakarchuk; Shawn DeFrees; Stephen G Withers; Natalie C J Strynadka
Structural insight into mammalian sialyltransferases.
Nature structural & molecular biology 2009;16(11):1186-8.
2009: Feng Liu; Ho Jun Lee; Natalie C J Strynadka; Martin E Tanner
Inhibition of Neisseria meningitidis sialic acid synthase by a tetrahedral intermediate analogue.
Biochemistry 2009;48(39):9194-201.
2009: Ho Jun Lee; Bojana Rakić; Michel Gilbert; Warren W Wakarchuk; Stephen G Withers; Natalie C J Strynadka
Structural and kinetic characterizations of the polysialic acid O-acetyltransferase OatWY from Neisseria meningitidis.
The Journal of biological chemistry 2009;284(36):24501-11.
2009: Trevor F Moraes; Rong-hua Yu; Natalie C J Strynadka; Anthony B Schryvers
Insights into the bacterial transferrin receptor: the structure of transferrin-binding protein B from Actinobacillus pleuropneumoniae.
Molecular cell 2009;35(4):523-33.
2009: Susan M Hancock; Jamie R Rich; Matthew E C Caines; Natalie C J Strynadka; Stephen G Withers
Designer enzymes for glycosphingolipid synthesis by directed evolution.
Nature chemical biology 2009;5(7):508-14.
2009: Michael Gretes; Daniel C Lim; Liza de Castro; Susan E Jensen; Sung Gyun Kang; Kye Joon Lee; Natalie C J Strynadka
Insights into positive and negative requirements for protein-protein interactions by crystallographic analysis of the beta-lactamase inhibitory proteins BLIP, BLIP-I, and BLP.
Journal of molecular biology 2009;389(2):289-305.
2009: Thomas Spreter; Calvin K Yip; Sarah Sanowar; Ingemar André; Tyler G Kimbrough; Marija Vuckovic; Richard A Pfuetzner; Wanyin Deng; Angel C Yu; B Brett Finlay; David Baker; Samuel I Miller; Natalie C J Strynadka
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
Nature structural & molecular biology 2009;16(5):468-76.
2009: Jenna K Capyk; Igor D'Angelo; Natalie C J Strynadka; Lindsay D Eltis
Characterization of 3-ketosteroid 9{alpha}-hydroxylase, a Rieske oxygenase in the cholesterol degradation pathway of Mycobacterium tuberculosis.
The Journal of biological chemistry 2009;284(15):9937-46.
2009: Katherine C Yam; Igor D'Angelo; Rainer Kalscheuer; Haizhong Zhu; Jian-Xin Wang; Victor Snieckus; Lan H Ly; Paul J Converse; William R. Jacobs Jr.; Natalie C J Strynadka; Lindsay D Eltis
Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosis.
PLoS pathogens 2009;5(3):e1000344.
2008: Matthew E C Caines; Haizhong Zhu; Marija Vuckovic; Lisa M Willis; Stephen G Withers; Warren W Wakarchuk; Natalie C J Strynadka
The structural basis for T-antigen hydrolysis by Streptococcus pneumoniae: a target for structure-based vaccine design.
The Journal of biological chemistry 2008;283(46):31279-83.
2008: Andrew L Lovering; Liza De Castro; Natalie C J Strynadka
Identification of dynamic structural motifs involved in peptidoglycan glycosyltransfer.
Journal of molecular biology 2008;383(1):167-77.
2008: Mark Okon; Trevor F Moraes; Paula Lario; A Louise Creagh; Charles A Haynes; Natalie C J Strynadka; Lawrence P McIntosh
Structural characterization of the type-III pilot-secretin complex from Shigella flexneri.
Structure (London, England : 1993) 2008;16(10):1544-54.
2008: Daan M F van Aalten; Natalie C J Strynadka
Putting glycobiology on a structural footing.
Current opinion in structural biology 2008;18(5):525-6.
2008: Andrew L Lovering; Michael Gretes; Natalie C J Strynadka
Structural details of the glycosyltransferase step of peptidoglycan assembly.
Current opinion in structural biology 2008;18(5):534-43.
2008: Mark S Wilke; Markus Heller; A Louise Creagh; Charles A Haynes; Lawrence P McIntosh; Keith Poole; Natalie C J Strynadka
The crystal structure of MexR from Pseudomonas aeruginosa in complex with its antirepressor ArmR.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(39):14832-7.
2008: Raz Zarivach; Wanyin Deng; Marija Vuckovic; Heather B Felise; Hai V Nguyen; Samuel I Miller; B Brett Finlay; Natalie C J Strynadka
Structural analysis of the essential self-cleaving type III secretion proteins EscU and SpaS.
Nature 2008;453(7191):124-7.
2008: Trevor F Moraes; Thomas Spreter; Natalie C J Strynadka
Piecing together the type III injectisome of bacterial pathogens.
Current opinion in structural biology 2008;18(2):258-66.
2007: Andrew L Lovering; Natalie C J Strynadka
High-resolution structure of the major periplasmic domain from the cell shape-determining filament MreC.
Journal of molecular biology 2007;372(4):1034-44.
2007: Jinoh Kim; Ajitha Thanabalasuriar; Tessa Chaworth-Musters; J Christopher Fromme; Elizabeth A Frey; Paula Lario; Pavel Metalnikov; Keyrillos Rizg; Nikhil A Thomas; Sau Fung Lee; Elizabeth L Hartland; Philip R Hardwidge; Tony Pawson; Natalie C J Strynadka; B Brett Finlay; Randy Schekman; Samantha Gruenheid
The bacterial virulence factor NleA inhibits cellular protein secretion by disrupting mammalian COPII function.
Cell host & microbe 2007;2(3):160-71.
2007: Denis M Daigle; Lily Cao; Sebastien Fraud; Mark S Wilke; Angela Pacey; Rachael Klinoski; Natalie C J Strynadka; Charles R Dean; Keith Poole
Protein modulator of multidrug efflux gene expression in Pseudomonas aeruginosa.
Journal of bacteriology 2007;189(15):5441-51.
2007: Cecilia P C Chiu; Luke L Lairson; Michel Gilbert; Warren W Wakarchuk; Stephen G Withers; Natalie C J Strynadka
Structural analysis of the alpha-2,3-sialyltransferase Cst-I from Campylobacter jejuni in apo and substrate-analogue bound forms.
Biochemistry 2007;46(24):7196-204.
2007: Matthew E C Caines; Mark D Vaughan; Chris A Tarling; Susan M Hancock; R Antony J Warren; Stephen G Withers; Natalie C J Strynadka
Structural and mechanistic analyses of endo-glycoceramidase II, a membrane-associated family 5 glycosidase in the Apo and GM3 ganglioside-bound forms.
The Journal of biological chemistry 2007;282(19):14300-8.
2007: Andrew L Lovering; Liza H de Castro; Daniel Lim; Natalie C J Strynadka
Structural insight into the transglycosylation step of bacterial cell-wall biosynthesis.
Science (New York, N.Y.) 2007;315(5817):1402-5.
2007: Raz Zarivach; Marija Vuckovic; Wanyin Deng; B Brett Finlay; Natalie C J Strynadka
Structural analysis of a prototypical ATPase from the type III secretion system.
Nature structural & molecular biology 2007;14(2):131-7.
2007: Matthew E C Caines; Susan M Hancock; Chris A Tarling; Tanja M Wrodnigg; Robert V Stick; Arnold E Stütz; Andrea Vasella; Stephen G Withers; Natalie C J Strynadka
The structural basis of glycosidase inhibition by five-membered iminocyclitols: the clan a glycoside hydrolase endoglycoceramidase as a model system.
Angewandte Chemie (International ed. in English) 2007;46(24):4474-6.
2007: Trevor F Moraes; Manjeet Bains; Robert E W Hancock; Natalie C J Strynadka
An arginine ladder in OprP mediates phosphate-specific transfer across the outer membrane.
Nature structural & molecular biology 2007;14(1):85-7.
2006: Leigh A Knodler; Michela Bertero; Calvin Yip; Natalie C J Strynadka; Olivia Steele-Mortimer
Structure-based mutagenesis of SigE verifies the importance of hydrophobic and electrostatic residues in type III chaperone function.
Molecular microbiology 2006;62(4):928-40.
2006: Amir Aharoni; Karena Thieme; Cecilia P C Chiu; Sabrina Buchini; Luke L Lairson; Hongming Chen; Natalie C J Strynadka; Warren W Wakarchuk; Stephen G Withers
High-throughput screening methodology for the directed evolution of glycosyltransferases.
Nature methods 2006;3(8):609-14.
2006: Ying A Wang; Xiong Yu; Calvin Yip; Natalie C J Strynadka; Edward H Egelman
Structural polymorphism in bacterial EspA filaments revealed by cryo-EM and an improved approach to helical reconstruction.
Structure (London, England : 1993) 2006;14(7):1189-96.
2006: Andrew L Lovering; Liza De Castro; Daniel Lim; Natalie C J Strynadka
Structural analysis of an "open" form of PBP1B from Streptococcus pneumoniae.
Protein science : a publication of the Protein Society 2006;15(7):1701-9.
2006: Calvin K Yip; Natalie C J Strynadka
New structural insights into the bacterial type III secretion system.
Trends in biochemical sciences 2006;31(4):223-30.
2006: Young-Wan Kim; Andrew L Lovering; Hongming Chen; Terrence Kantner; Lawrence P McIntosh; Natalie C J Strynadka; Stephen G Withers
Expanding the thioglycoligase strategy to the synthesis of alpha-linked thioglycosides allows structural investigation of the parent enzyme/substrate complex.
Journal of the American Chemical Society 2006;128(7):2202-3.
2005: Mark S Wilke; Andrew L Lovering; Natalie C J Strynadka
Beta-lactam antibiotic resistance: a current structural perspective.
Current opinion in microbiology 2005;8(5):525-33.
2005: Nikhil A Thomas; Wanyin Deng; José Luis Puente; Elizabeth A Frey; Calvin K Yip; Natalie C J Strynadka; B Brett Finlay
CesT is a multi-effector chaperone and recruitment factor required for the efficient type III secretion of both LEE- and non-LEE-encoded effectors of enteropathogenic Escherichia coli.
Molecular microbiology 2005;57(6):1762-79.
2005: Victor W T Cheng; Richard A Rothery; Michela G Bertero; Natalie C J Strynadka; Joel Weiner
Investigation of the environment surrounding iron-sulfur cluster 4 of Escherichia coli dimethylsulfoxide reductase.
Biochemistry 2005;44(22):8068-77.
2005: Calvin K Yip; Tyler G Kimbrough; Heather B Felise; Marija Vuckovic; Nikhil A Thomas; Richard A Pfuetzner; Elizabeth A Frey; B Brett Finlay; Samuel I Miller; Natalie C J Strynadka
Structural characterization of the molecular platform for type III secretion system assembly.
Nature 2005;435(7042):702-7.
2005: Michela G Bertero; Richard A Rothery; Nasim Boroumand; Monica Palak; Francis Blasco; Nicolas Ginet; Joel Weiner; Natalie C J Strynadka
Structural and biochemical characterization of a quinol binding site of Escherichia coli nitrate reductase A.
The Journal of biological chemistry 2005;280(15):14836-43.
2005: Mark Okon; Richard A Pfuetzner; Mariha Vuckovic; John W Little; Natalie C J Strynadka; Lawrence P McIntosh
Backbone chemical shift assignments of the LexA catalytic domain in its active conformation.
Journal of biomolecular NMR 2005;31(4):371-2.
2005: Paula Lario; Richard A Pfuetzner; Elizabeth A Frey; Louise Creagh; Charles Haynes; Anthony T Maurelli; Natalie C J Strynadka
Structure and biochemical analysis of a secretin pilot protein.
The EMBO journal 2005;24(6):1111-21.
2005: Jason Gunawan; Dave Simard; Michel Gilbert; Andrew L Lovering; Warren W Wakarchuk; Martin E Tanner; Natalie C J Strynadka
Structural and mechanistic analysis of sialic acid synthase NeuB from Neisseria meningitidis in complex with Mn2+, phosphoenolpyruvate, and N-acetylmannosaminitol.
The Journal of biological chemistry 2005;280(5):3555-63.
2005: Andrew L Lovering; Seung Seo Lee; Young-Wan Kim; Stephen G Withers; Natalie C J Strynadka
Mechanistic and structural analysis of a family 31 alpha-glycosidase and its glycosyl-enzyme intermediate.
The Journal of biological chemistry 2005;280(3):2105-15.
2005: Calvin K Yip; B Brett Finlay; Natalie C J Strynadka
Structural characterization of a type III secretion system filament protein in complex with its chaperone.
Nature structural & molecular biology 2005;12(1):75-81.
2004: Lodovica Loschi; Stephen J Brokx; Tanya L Hills; Glen Zhang; Michela G Bertero; Andrew L Lovering; Joel Weiner; Natalie C J Strynadka
Structural and biochemical identification of a novel bacterial oxidoreductase.
The Journal of biological chemistry 2004;279(48):50391-400.
2004: Mark S Wilke; Tanya L Hills; Hong-Zhong Zhang; Henry F Chambers; Natalie C J Strynadka
Crystal structures of the Apo and penicillin-acylated forms of the BlaR1 beta-lactam sensor of Staphylococcus aureus.
The Journal of biological chemistry 2004;279(45):47278-87.
2004: Mario Schubert; Robert E Edge; Paula Lario; Michael A Cook; Natalie C J Strynadka; George A Mackie; Lawrence P McIntosh
Structural characterization of the RNase E S1 domain and identification of its oligonucleotide-binding and dimerization interfaces.
Journal of molecular biology 2004;341(1):37-54.
2004: Luke L Lairson; Cecilia P C Chiu; Hoa D Ly; Shouming He; Warren W Wakarchuk; Natalie C J Strynadka; Stephen G Withers
Intermediate trapping on a mutant retaining alpha-galactosyltransferase identifies an unexpected aspartate residue.
The Journal of biological chemistry 2004;279(27):28339-44.
2004: Richard A Rothery; Michela G Bertero; Richard Cammack; Monica Palak; Francis Blasco; Natalie C J Strynadka; Joel Weiner
The catalytic subunit of Escherichia coli nitrate reductase A contains a novel [4Fe-4S] cluster with a high-spin ground state.
Biochemistry 2004;43(18):5324-33.
2004: Cecilia P C Chiu; Andrew G Watts; Luke L Lairson; Michel Gilbert; Daniel Lim; Warren W Wakarchuk; Stephen G Withers; Natalie C J Strynadka
Structural analysis of the sialyltransferase CstII from Campylobacter jejuni in complex with a substrate analog.
Nature structural & molecular biology 2004;11(2):163-70.
2003: Michela G Bertero; Richard A Rothery; Monica Palak; Cynthia Hou; Daniel Lim; Francis Blasco; Joel Weiner; Natalie C J Strynadka
Insights into the respiratory electron transfer pathway from the structure of nitrate reductase A.
Nature structural biology 2003;10(9):681-7.
2003: Michael J Page; Sui-Lam Wong; Jeff Hewitt; Natalie C J Strynadka; Ross T A MacGillivray
Engineering the primary substrate specificity of Streptomyces griseus trypsin.
Biochemistry 2003;42(30):9060-6.
2002: Stephen G Withers; Warren W Wakarchuk; Natalie C J Strynadka
One step closer to a sweet conclusion.
Chemistry & biology 2002;9(12):1270-3.
2002: Mark Paetzel; Andrew Karla; Natalie C J Strynadka; Ross E Dalbey
Signal peptidases.
Chemical reviews 2002;102(12):4549-80.
2002: Daniel Lim; Natalie C J Strynadka
Structural basis for the beta lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus.
Nature structural biology 2002;9(11):870-6.
2002: Daniel Lim; Keith Poole; Natalie C J Strynadka
Crystal structure of the MexR repressor of the mexRAB-oprM multidrug efflux operon of Pseudomonas aeruginosa.
The Journal of biological chemistry 2002;277(32):29253-9.
2002: Mark Paetzel; Ross E Dalbey; Natalie C J Strynadka
Crystal structure of a bacterial signal peptidase apoenzyme: implications for signal peptide binding and the Ser-Lys dyad mechanism.
The Journal of biological chemistry 2002;277(11):9512-9.
2001: Jomy Samuel; Y Luo; P M Morgan; Natalie C J Strynadka; Martin E Tanner
Catalysis and binding in L-ribulose-5-phosphate 4-epimerase: a comparison with L-fuculose-1-phosphate aldolase.
Biochemistry 2001;40(49):14772-80.
2001: Y Luo; Jomy Samuel; SC Mosimann; J E Lee; Martin E Tanner; Natalie C J Strynadka
The structure of L-ribulose-5-phosphate 4-epimerase: an aldolase-like platform for epimerization.
Biochemistry 2001;40(49):14763-71.
2001: Y Luo; Michela G Bertero; Elizabeth A Frey; Richard A Pfuetzner; M R Wenk; Louise Creagh; Sandra L Marcus; Daniel Lim; F Sicheri; C Kay; Charles Haynes; B Brett Finlay; Natalie C J Strynadka
Structural and biochemical characterization of the type III secretion chaperones CesT and SigE.
Nature structural biology 2001;8(12):1031-6.
2001: Daniel Lim; Hyeon Ung Park; L De Castro; S G Kang; H S Lee; S Jensen; K J Lee; Natalie C J Strynadka
Crystal structure and kinetic analysis of beta-lactamase inhibitor protein-II in complex with TEM-1 beta-lactamase.
Nature structural biology 2001;8(10):848-52.
2001: Y Luo; Richard A Pfuetzner; SC Mosimann; Mark Paetzel; Elizabeth A Frey; M Cherney; B Kim; J W Little; Natalie C J Strynadka
Crystal structure of LexA: a conformational switch for regulation of self-cleavage.
Cell 2001;106(5):585-94.
2001: AP White; SK Collinson; PA Banser; DL Gibson; Mark Paetzel; Natalie C J Strynadka; William W Kay
Structure and characterization of AgfB from Salmonella enteritidis thin aggregative fimbriae.
Journal of molecular biology 2001;311(4):735-49.
2001: Franck Danel; Mark Paetzel; Natalie C J Strynadka; Malcolm G P Page
Effect of divalent metal cations on the dimerization of OXA-10 and -14 class D beta-lactamases from Pseudomonas aeruginosa.
Biochemistry 2001;40(31):9412-20.
2001: SC Mosimann; Michel Gilbert; D Dombroswki; R To; Warren W Wakarchuk; Natalie C J Strynadka
Structure of a sialic acid-activating synthetase, CMP-acylneuraminate synthetase in the presence and absence of CDP.
The Journal of biological chemistry 2001;276(11):8190-6.
2001: K Persson; Hoa D Ly; M Dieckelmann; Warren W Wakarchuk; Stephen G Withers; Natalie C J Strynadka
Crystal structure of the retaining galactosyltransferase LgtC from Neisseria meningitidis in complex with donor and acceptor sugar analogs.
Nature structural biology 2001;8(2):166-75.
2001: D Lim; François Sanschagrin; L Passmore; L De Castro; Roger C Levesque; Natalie C J Strynadka
Insights into the molecular basis for the carbenicillinase activity of PSE-4 beta-lactamase from crystallographic and kinetic studies.
Biochemistry 2001;40(2):395-402.
2000: RE Campbell; SC Mosimann; Martin E Tanner; Natalie C J Strynadka
The structure of UDP-N-acetylglucosamine 2-epimerase reveals homology to phosphoglycosyl transferases.
Biochemistry 2000;39(49):14993-5001.
2000: Mark Paetzel; Franck Danel; L de Castro; SC Mosimann; Malcolm G P Page; Natalie C J Strynadka
Crystal structure of the class D beta-lactamase OXA-10.
Nature structural biology 2000;7(10):918-25.
2000: Mark Paetzel; Ross E Dalbey; Natalie C J Strynadka
The structure and mechanism of bacterial type I signal peptidases. A novel antibiotic target.
Pharmacology & therapeutics 2000;87(1):27-49.
2000: Y Luo; Elizabeth A Frey; Richard A Pfuetzner; A Louise Creagh; DG Knoechel; Charles A Haynes; B Brett Finlay; Natalie C J Strynadka
Crystal structure of enteropathogenic Escherichia coli intimin-receptor complex.
Nature 2000;405(6790):1073-7.
2000: JL Carlos; P A Klenotic; Mark Paetzel; Natalie C J Strynadka; Ross E Dalbey
Mutational evidence of transition state stabilization by serine 88 in Escherichia coli type I signal peptidase.
Biochemistry 2000;39(24):7276-83.
2000: Danika L Goosney; R DeVinney; Richard A Pfuetzner; Elizabeth A Frey; Natalie C J Strynadka; B Brett Finlay
Enteropathogenic E. coli translocated intimin receptor, Tir, interacts directly with alpha-actinin.
Current biology : CB 2000;10(12):735-8.
2000: RE Campbell; SC Mosimann; Ivo van de Rijn; Martin E Tanner; Natalie C J Strynadka
The first structure of UDP-glucose dehydrogenase reveals the catalytic residues necessary for the two-fold oxidation.
Biochemistry 2000;39(23):7012-23.
2000: S Ness; R Martin; A M Kindler; Mark Paetzel; M Gold; S E Jensen; J B Jones; Natalie C J Strynadka
Structure-based design guides the improved efficacy of deacylation transition state analogue inhibitors of TEM-1 beta-Lactamase(,).
Biochemistry 2000;39(18):5312-21.
2000: P A Klenotic; JL Carlos; James C Samuelson; T A Schuenemann; William Tschantz; Mark Paetzel; Natalie C J Strynadka; Ross E Dalbey
The role of the conserved box E residues in the active site of the Escherichia coli type I signal peptidase.
The Journal of biological chemistry 2000;275(9):6490-8.
1999: Mark Paetzel; Natalie C J Strynadka
Common protein architecture and binding sites in proteases utilizing a Ser/Lys dyad mechanism.
Protein science : a publication of the Protein Society 1999;8(11):2533-6.
1999: Augusto S Abe; Myriam De Grado; Richard A Pfuetzner; C Sánchez-Sanmartín; R DeVinney; José Luis Puente; Natalie C J Strynadka; B Brett Finlay
Enteropathogenic Escherichia coli translocated intimin receptor, Tir, requires a specific chaperone for stable secretion.
Molecular microbiology 1999;33(6):1162-75.
1998: Mark Paetzel; Ross E Dalbey; Natalie C J Strynadka
Crystal structure of a bacterial signal peptidase in complex with a beta-lactam inhibitor.
Nature 1998;396(6707):186-90.
1997: Natalie C J Strynadka; Maia M Cherney; A R Sielecki; Monica X Li; Lawrence B Smillie; Michael N G James
Structural details of a calcium-induced molecular switch: X-ray crystallographic analysis of the calcium-saturated N-terminal domain of troponin C at 1.75 A resolution.
Journal of molecular biology 1997;273(1):238-55.
1997: Mark Paetzel; Natalie C J Strynadka; William Tschantz; R Casareno; P R Bullinger; Ross E Dalbey
Use of site-directed chemical modification to study an essential lysine in Escherichia coli leader peptidase.
The Journal of biological chemistry 1997;272(15):9994-10003.
1995: Mark Paetzel; M Chernaia; Natalie C J Strynadka; W Tschantz; G Cao; Ross E Dalbey; M N James
Crystallization of a soluble, catalytically active form of Escherichia coli leader peptidase.
Proteins 1995;23(1):122-5.
1991: Rui Brito; John A Putkey; Natalie C J Strynadka; M N James; Paul R Rosevear
Comparative NMR studies on cardiac troponin C and a mutant incapable of binding calcium at site II.
Biochemistry 1991;30(42):10236-45.