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David Stuart

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X Ray Crystallography

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Bacteriophage phi 6

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TOP 3
Ilona Rissanen; Jaana K H Bamford; Jonathan M Grimes; Karl Harlos; Sari Mäntynen; Alice Pawlowski; David I Stuart
Bacteriophage p23-77 capsid protein structures reveal the archetype of an ancient branch from a major virus lineage.
Claudine Porta; Jingshan Ren; David I Stuart; Alison Burman; Elizabeth E Fry; Terry Jackson; Ian M Jones; Abhay Kotecha; Silvia Loureiro; Bryan Charleston
Rational engineering of recombinant picornavirus capsids to produce safe, protective vaccine antigen.
Mohammad W Bahar; Dennis H Bamford; Stephen C Graham; Jances Pang; L Peter Sarin; David I Stuart; Jonathan M Grimes
Structure of a VP1-VP3 complex suggests how birnaviruses package the VP1 polymerase.

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2013: Ilona Rissanen; Jaana K H Bamford; Jonathan M Grimes; Karl Harlos; Sari Mäntynen; Alice Pawlowski; David I Stuart
Bacteriophage p23-77 capsid protein structures reveal the archetype of an ancient branch from a major virus lineage.
Structure (London, England : 1993) 2013;21(5):718-26.
2013: Claudine Porta; Jingshan Ren; David I Stuart; Alison Burman; Elizabeth E Fry; Terry Jackson; Ian M Jones; Abhay Kotecha; Silvia Loureiro; Bryan Charleston
Rational engineering of recombinant picornavirus capsids to produce safe, protective vaccine antigen.
PLoS pathogens 2013;9(3):e1003255.
2013: Mohammad W Bahar; Dennis H Bamford; Stephen C Graham; Jances Pang; L Peter Sarin; David I Stuart; Jonathan M Grimes
Structure of a VP1-VP3 complex suggests how birnaviruses package the VP1 polymerase.
Journal of virology 2013;87(6):3229-36.
2013: Claudine Porta; Junyuan Ren; David I Stuart; Ginette Wilsden; Xiaodong Xu; Tara Al-Khalil; Graham J Belsham; Alison Burman; Bryan Charleston; Stephen Curry; Nigel P Ferris; Elizabeth Fry; Terry Jackson; Abhay Kotecha; Yanmin Li; George P Lomonossoff; Silvia Loureiro; Ray Owens; Saravanan Paramasivam; Satya Parida; David Paton; Ian M Jones
Efficient production of foot-and-mouth disease virus empty capsids in insect cells following down regulation of 3C protease activity.
Journal of virological methods 2013;187(2):406-12.
2013: Kamel El Omari; Jonathan M Grimes; Karl Harlos; Oleg Iourin; David I Stuart
Structure of a pestivirus envelope glycoprotein E2 clarifies its role in cell entry.
Cell reports 2013;3(1):30-5.
2013: Michael A DiMattia; Jonathan M Grimes; Stephen J Stahl; Alasdair C Steven; David I Stuart; Norman R Watts; Paul T Wingfield
Antigenic switching of hepatitis B virus by alternative dimerization of the capsid protein.
Structure (London, England : 1993) 2013;21(1):133-42.
2013: Daryl W Borley; Robert M Esnouf; Mana Mahapatra; David J Paton; David I Stuart; Elizabeth E Fry
Evaluation and Use of In-Silico Structure-Based Epitope Prediction with Foot-and-Mouth Disease Virus.
PloS one 2013;8(5):e61122.
2013: Oleg Iourin; Munir Iqbal; Ian Jones; Jan kadlec; Weixian Lu; Christoph Meier; Andrew Palmer; Joe Brownlie; Kamel El Omari; Jonathan M Grimes; Karl Harlos; Carole Thomas; David I Stuart
Expression, purification and crystallization of the ectodomain of the envelope glycoprotein E2 from Bovine viral diarrhoea virus.
Acta crystallographica. Section F, Structural biology and crystallization communications 2013;69(Pt 1):35-8.
2012: L Peter Sarin; David I Stuart; Sam Wright; Dennis H Bamford; Qing Chen; Linda H Degerth; Jonathan M Grimes; Minna M Poranen
The C-terminal priming domain is strongly associated with the main body of bacteriophage ϕ6 RNA-dependent RNA polymerase.
Virology 2012;432(1):184-93.
2012: thomas walter; Jingshan Ren; David J Rowlands; David I Stuart; Tobias J Tuthill; Elizabeth E Fry
A plate-based high-throughput assay for virus stability and vaccine formulation.
Journal of virological methods 2012;185(1):166-70.
2012: Sarah Sainsbury; Nigel J Saunders; David I Stuart; Jingshan Ren; Raymond J Owens
Structure of the regulatory domain of the LysR family regulator NMB2055 (MetR-like protein) from Neisseria meningitidis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2012;68(Pt 7):730-7.
2012: Ilona Rissanen; David I Stuart; Jonathan M Grimes; Karl Harlos; Alice Pawlowski; Jaana K H Bamford
Crystallization and preliminary crystallographic analysis of the major capsid proteins VP16 and VP17 of bacteriophage P23-77.
Acta crystallographica. Section F, Structural biology and crystallization communications 2012;68(Pt 5):580-3.
2012: Sam Wright; Dennis H Bamford; Minna M Poranen; David I Stuart; Jonathan M Grimes
Noncatalytic ions direct the RNA-dependent RNA polymerase of bacterial double-stranded RNA virus ϕ6 from de novo initiation to elongation.
Journal of virology 2012;86(5):2837-49.
2011: Ed Daniel; Jonathan M Diprose; Ian M Berry; Richard Blake; Susanne L Griffiths; Bill Lin; Chris Morris; Raymond J Owens; David I Stuart; Keith S Wilson; Robert M Esnouf
xtalPiMS: a PiMS-based web application for the management and monitoring of crystallization trials.
Journal of structural biology 2011;175(2):230-5.
2011: Marc Savitsky; Christian Siebold; David I Stuart; Keith S Wilson; Benjamin Bishop; Richard Blake; Susan Daenke; Edward Daniel; Jonathan M Diprose; Susanne L Griffiths; Bill Lin; Chris Morris; Robert M Esnouf
Recording information on protein complexes in an information management system.
Journal of structural biology 2011;175(2):224-9.
2011: Yuguang Zhao; E Yvonne Jones; Benjamin Bishop; Jordan E Clay; Susan Daenke; Margaret Jones; Weixian Lu; Christian Siebold; David I Stuart; A Radu Aricescu
Automation of large scale transient protein expression in mammalian cells.
Journal of structural biology 2011;175(2):209-15.
2011: Thomas A Bowden; E Yvonne Jones; David I Stuart
Cells under siege: viral glycoprotein interactions at the cell surface.
Journal of structural biology 2011;175(2):120-6.
2011: Mohammad W Bahar; Ron A-J Chen; Samantha Cooray; Stephen C Graham; Geoffrey L Smith; David I Stuart; Jonathan M Grimes
How vaccinia virus has evolved to subvert the host immune response.
Journal of structural biology 2011;175(2):127-34.
2011: Mohammad W Bahar; Stephen C Graham; David I Stuart; Jonathan M Grimes
Insights into the evolution of a complex virus from the crystal structure of vaccinia virus D13.
Structure (London, England : 1993) 2011;19(7):1011-20.
2011: Chao Yu; Veronica T Chang; Max Crispin; Edward J Evans; Robert J C Gilbert; David J Harvey; Christopher N Scanlan; Andreas F-P Sonnen; David I Stuart; Simon J Davis
Use of the α-mannosidase I inhibitor kifunensine allows the crystallization of apo CTLA-4 homodimer produced in long-term cultures of Chinese hamster ovary cells.
Acta crystallographica. Section F, Structural biology and crystallization communications 2011;67(Pt 7):785-9.
2011: Stephen C Graham; Mohammad W Bahar; Dennis H Bamford; Reg A Myers; L Peter Sarin; David I Stuart; Jonathan M Grimes
The N-terminus of the RNA polymerase from infectious pancreatic necrosis virus is the determinant of genome attachment.
PLoS pathogens 2011;7(6):e1002085.
2011: Chris Morris; Anne Pajon; Susanne L Griffiths; Ed Daniel; Marc Savitsky; Bill Lin; Jonathan M Diprose; Alan Wilter da Silva; Katya Pilicheva; Peter Troshin; Johannes van Niekerk; Neil Isaacs; James Naismith; Colin Nave; Richard Blake; Keith S Wilson; David I Stuart; Kim Henrick; Robert M Esnouf
The Protein Information Management System (PiMS): a generic tool for any structural biology research laboratory.
Acta crystallographica. Section D, Biological crystallography 2011;67(Pt 4):249-60.
2011: Chao Yu; Andreas F-P Sonnen; Roger George; Benoit H Dessailly; Loren J Stagg; Edward J Evans; Christine A Orengo; David I Stuart; John E Ladbury; Shinji Ikemizu; Robert J C Gilbert; Simon J Davis
Rigid-body ligand recognition drives cytotoxic T-lymphocyte antigen 4 (CTLA-4) receptor triggering.
The Journal of biological chemistry 2011;286(8):6685-96.
2011: Sarah Sainsbury; Louise Bird; Vincenzo Rao; Sharon M Shepherd; David I Stuart; William N Hunter; Raymond J Owens; Jingshan Ren
Crystal structures of penicillin-binding protein 3 from Pseudomonas aeruginosa: comparison of native and antibiotic-bound forms.
Journal of molecular biology 2011;405(1):173-84.
2010: Thomas A Bowden; Max Crispin; E Yvonne Jones; David I Stuart
Shared paramyxoviral glycoprotein architecture is adapted for diverse attachment strategies.
Biochemical Society transactions 2010;38(5):1349-55.
2010: Antti P Aalto; Minna M Poranen; Jonathan M Grimes; David I Stuart; Dennis H Bamford
In vitro activities of the multifunctional RNA silencing polymerase QDE-1 of Neurospora crassa.
The Journal of biological chemistry 2010;285(38):29367-74.
2010: Elizabeth Fry; Tobias J Tuthill; Karl Harlos; thomas walter; David J Rowlands; David I Stuart
Crystal structure of equine rhinitis A virus in complex with its sialic acid receptor.
The Journal of general virology 2010;91(Pt 8):1971-7.
2010: Rene Assenberg; O Delmas; B Morin; Stephen C Graham; X De Lamballerie; C Laubert; Bruno Coutard; Jonathan M Grimes; J Neyts; Raymond J Owens; B W Brandt; A Gorbalenya; P Tucker; David I Stuart; B Canard; Hervé Bourhy
Genomics and structure/function studies of Rhabdoviridae proteins involved in replication and transcription.
Antiviral research 2010;87(2):149-61.
2010: Andreas F-P Sonnen; Chao Yu; Edward J Evans; David I Stuart; Simon J Davis; Robert J C Gilbert
Domain metastability: a molecular basis for immunoglobulin deposition?
Journal of molecular biology 2010;399(2):207-13.
2010: Thomas A Bowden; Max Crispin; David Harvey; E Yvonne Jones; David I Stuart
Dimeric architecture of the Hendra virus attachment glycoprotein: evidence for a conserved mode of assembly.
Journal of virology 2010;84(12):6208-17.
2010: Michael A DiMattia; Norman R Watts; Stephen J Stahl; Christoph Rader; Paul T Wingfield; David I Stuart; Alasdair C Steven; Jonathan M Grimes
Implications of the HIV-1 Rev dimer structure at 3.2 A resolution for multimeric binding to the Rev response element.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(13):5810-4.
2010: Christian H Bell; Steven L Porter; Annabel Strawson; David I Stuart; Judith P Armitage
Using structural information to change the phosphotransfer specificity of a two-component chemotaxis signalling complex.
PLoS biology 2010;8(2):e1000306.
2010: Xiaoyun Ji; Geoff Sutton; Gwyndaf Evans; Danny Axford; Robin Owen; David I Stuart
How baculovirus polyhedra fit square pegs into round holes to robustly package viruses.
The EMBO journal 2010;29(2):505-14.
2010: Sarah Sainsbury; Jingshan Ren; Joanne E Nettleship; Nigel J Saunders; David I Stuart; Raymond J Owens
The structure of a reduced form of OxyR from Neisseria meningitidis.
BMC structural biology 2010;10():10.
2009: Rene Assenberg; Eloise Mastrangelo; thomas walter; Anil Verma; Mario Milani; Raymond J Owens; David I Stuart; Jonathan M Grimes; erika mancini
Crystal structure of a novel conformational state of the flavivirus NS3 protein: implications for polyprotein processing and viral replication.
Journal of virology 2009;83(24):12895-906.
2009: Gijs I van Boxel; Guillaume Stewart-Jones; Samantha Holmes; Sarah Sainsbury; Dawn Shepherd; G M A Gillespie; Karl Harlos; David I Stuart; Ray Owens; E Yvonne Jones
Some lessons from the systematic production and structural analysis of soluble (alpha)(beta) T-cell receptors.
Journal of immunological methods 2009;350(1-2):14-21.
2009: Thomas A Bowden; A Radu Aricescu; Joanne E Nettleship; Christian Siebold; Nahid Rahman-Huq; Raymond J Owens; David I Stuart; E Yvonne Jones
Structural plasticity of eph receptor A4 facilitates cross-class ephrin signaling.
Structure (London, England : 1993) 2009;17(10):1386-97.
2009: Deborah Hatherley; Stephen C Graham; Karl Harlos; David I Stuart; A Neil Barclay
Structure of signal-regulatory protein alpha: a link to antigen receptor evolution.
The Journal of biological chemistry 2009;284(39):26613-9.
2009: Thomas A Bowden; Max Crispin; Stephen C Graham; David Harvey; Jonathan M Grimes; E Yvonne Jones; David I Stuart
Unusual molecular architecture of the machupo virus attachment glycoprotein.
Journal of virology 2009;83(16):8259-65.
2009: Sarah Sainsbury; Laura A Lane; Jingshan Ren; Robert J Gilbert; Nigel J Saunders; Carol V Robinson; David I Stuart; Raymond J Owens
The structure of CrgA from Neisseria meningitidis reveals a new octameric assembly state for LysR transcriptional regulators.
Nucleic acids research 2009;37(14):4545-58.
2009: Guido C Paesen; Christian Siebold; Mark L Dallas; Chris Peers; Karl Harlos; Patricia A Nuttall; Miles A Nunn; David I Stuart; Robert M Esnouf
An ion-channel modulator from the saliva of the brown ear tick has a highly modified Kunitz/BPTI structure.
Journal of molecular biology 2009;389(4):734-47.
2009: thomas walter; Changzhen Liu; Peng Huang; Shiqian Zhang; Lucy R Wedderburn; Bin Gao; Raymond J Owens; David I Stuart; Peifu Tang; Jingshan Ren
Crystallization and preliminary X-ray analysis of mouse RANK and its complex with RANKL.
Acta crystallographica. Section F, Structural biology and crystallization communications 2009;65(Pt 6):597-600.
2009: Max Crispin; Thomas A Bowden; Charlotte H Coles; Karl Harlos; A Radu Aricescu; David Harvey; David I Stuart; E Yvonne Jones
Carbohydrate and domain architecture of an immature antibody glycoform exhibiting enhanced effector functions.
Journal of molecular biology 2009;387(5):1061-6.
2009: L Peter Sarin; Minna M Poranen; N Marika Lehti; Janne J Ravantti; Minni R L Koivunen; Antti P Aalto; Alberdina A van Dijk; David I Stuart; Jonathan M Grimes; Dennis H Bamford
Insights into the pre-initiation events of bacteriophage phi 6 RNA-dependent RNA polymerase: towards the assembly of a productive binary complex.
Nucleic acids research 2009;37(4):1182-92.
2008: Stephen C Graham; Rene Assenberg; Olivier Delmas; Anil Verma; Alireza Gholami; Chiraz Talbi; Raymond J Owens; David I Stuart; Jonathan M Grimes; Hervé Bourhy
Rhabdovirus matrix protein structures reveal a novel mode of self-association.
PLoS pathogens 2008;4(12):e1000251.
2008: Thomas A Bowden; Max Crispin; David Harvey; A Radu Aricescu; Jonathan M Grimes; E Yvonne Jones; David I Stuart
Crystal structure and carbohydrate analysis of Nipah virus attachment glycoprotein: a template for antiviral and vaccine design.
Journal of virology 2008;82(23):11628-36.
2008: Minna M Poranen; Paula S Salgado; Minni R L Koivunen; Sam Wright; Dennis H Bamford; David I Stuart; Jonathan M Grimes
Structural explanation for the role of Mn2+ in the activity of phi6 RNA-dependent RNA polymerase.
Nucleic acids research 2008;36(20):6633-44.
2008: Jan kadlec; Silvia Loureiro; Nicola G A Abrescia; David I Stuart; Ian M Jones
The postfusion structure of baculovirus gp64 supports a unified view of viral fusion machines.
Nature structural & molecular biology 2008;15(10):1024-30.
2008: Christoph Meier; Lester G Carter; Sarah Sainsbury; erika mancini; Raymond J Owens; David I Stuart; Robert M Esnouf
The crystal structure of UMP kinase from Bacillus anthracis (BA1797) reveals an allosteric nucleotide-binding site.
Journal of molecular biology 2008;381(5):1098-105.
2008: Nicola G A Abrescia; Jonathan M Grimes; Hanna M Kivelä; Rene Assenberg; Geoff C Sutton; Sarah J Butcher; Jaana K H Bamford; Dennis H Bamford; David I Stuart
Insights into virus evolution and membrane biogenesis from the structure of the marine lipid-containing bacteriophage PM2.
Molecular cell 2008;31(5):749-61.
2008: Sarah Sainsbury; Jingshan Ren; Nigel J Saunders; David I Stuart; Raymond J Owens
Crystallization and preliminary X-ray analysis of CrgA, a LysR-type transcriptional regulator from pathogenic Neisseria meningitidis MC58.
Acta crystallographica. Section F, Structural biology and crystallization communications 2008;64(Pt 9):797-801.
2008: Deborah Hatherley; Stephen C Graham; Jessie Turner; Karl Harlos; David I Stuart; A Neil Barclay
Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47.
Molecular cell 2008;31(2):266-77.
2008: Thomas A Bowden; A Radu Aricescu; Robert J C Gilbert; Jonathan M Grimes; E Yvonne Jones; David I Stuart
Structural basis of Nipah and Hendra virus attachment to their cell-surface receptor ephrin-B2.
Nature structural & molecular biology 2008;15(6):567-72.
2008: Stephen J Moran; John F Flanagan; Olivier Namy; David I Stuart; Ian Brierley; Robert J C Gilbert
The mechanics of translocation: a molecular "spring-and-ratchet" system.
Structure (London, England : 1993) 2008;16(5):664-72.
2008: Kinfai Au; Jingshan Ren; thomas walter; Karl Harlos; Joanne E Nettleship; Raymond J Owens; David I Stuart; Robert M Esnouf
Structures of an alanine racemase from Bacillus anthracis (BA0252) in the presence and absence of (R)-1-aminoethylphosphonic acid (L-Ala-P).
Acta crystallographica. Section F, Structural biology and crystallization communications 2008;64(Pt 5):327-33.
2008: Rene Assenberg; Olivier Delmas; Stephen C Graham; Anil Verma; Nick S Berrow; David I Stuart; Raymond J Owens; Hervé Bourhy; Jonathan M Grimes
Expression, purification and crystallization of a lyssavirus matrix (M) protein.
Acta crystallographica. Section F, Structural biology and crystallization communications 2008;64(Pt 4):258-62.
2008: Denis E Kainov; erika mancini; Jelena Telenius; Jirí Lísal; Jonathan M Grimes; Dennis H Bamford; David I Stuart; Roman Tuma
Structural basis of mechanochemical coupling in a hexameric molecular motor.
The Journal of biological chemistry 2008;283(6):3607-17.
2008: Hanna M Kivelä; Nicola G A Abrescia; Jaana K H Bamford; Jonathan M Grimes; David I Stuart; Dennis H Bamford
Selenomethionine labeling of large biological macromolecular complexes: probing the structure of marine bacterial virus PM2.
Journal of structural biology 2008;161(2):204-10.
2008: Nathan R Zaccai; Lester G Carter; Nick S Berrow; Sarah Sainsbury; Joanne E Nettleship; thomas walter; Karl Harlos; Raymond J Owens; Keith S Wilson; David I Stuart; Robert M Esnouf
Crystal structure of a 3-oxoacyl-(acylcarrier protein) reductase (BA3989) from Bacillus anthracis at 2.4-A resolution.
Proteins 2008;70(2):562-7.
2008: Stephen C Graham; Mohammad W Bahar; Samantha Cooray; Ron A-J Chen; Daniel M Whalen; Nicola G A Abrescia; David Alderton; Raymond J Owens; David I Stuart; Geoffrey L Smith; Jonathan M Grimes
Vaccinia virus proteins A52 and B14 Share a Bcl-2-like fold but have evolved to inhibit NF-kappaB rather than apoptosis.
PLoS pathogens 2008;4(8):e1000128.
2008: Mohammad W Bahar; Julia C Kenyon; Mike M Putz; Nicola G A Abrescia; James E Pease; Emma L Wise; David I Stuart; Geoffrey L Smith; Jonathan M Grimes
Structure and function of A41, a vaccinia virus chemokine binding protein.
PLoS pathogens 2008;4(1):e5.
2008: thomas walter; erika mancini; Jan kadlec; Stephen C Graham; Rene Assenberg; Jingshan Ren; Sarah Sainsbury; Raymond J Owens; David I Stuart; Jonathan M Grimes; Karl Harlos
Semi-automated microseeding of nanolitre crystallization experiments.
Acta crystallographica. Section F, Structural biology and crystallization communications 2008;64(Pt 1):14-8.
2007: erika mancini; Rene Assenberg; Anil Verma; thomas walter; Roman Tuma; Jonathan M Grimes; Raymond J Owens; David I Stuart
Structure of the Murray Valley encephalitis virus RNA helicase at 1.9 Angstrom resolution.
Protein science : a publication of the Protein Society 2007;16(10):2294-300.
2007: Stephen C Graham; Mohammad W Bahar; Nicola G A Abrescia; Geoffrey L Smith; David I Stuart; Jonathan M Grimes
Structure of CrmE, a virus-encoded tumour necrosis factor receptor.
Journal of molecular biology 2007;372(3):660-71.
2007: Rene Assenberg; Jingshan Ren; Anil Verma; thomas walter; David Alderton; Robert J Hurrelbrink; Stephen D Fuller; Stéphane Bressanelli; Raymond J Owens; David I Stuart; Jonathan M Grimes
Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase domain in complex with cap analogues.
The Journal of general virology 2007;88(Pt 8):2228-36.
2007: Samantha Cooray; Mohammad W Bahar; Nicola G A Abrescia; Colin E McVey; Nathan W Bartlett; Ron A-J Chen; David I Stuart; Jonathan M Grimes; Geoffrey L Smith
Functional and structural studies of the vaccinia virus virulence factor N1 reveal a Bcl-2-like anti-apoptotic protein.
The Journal of general virology 2007;88(Pt 6):1656-66.
2007: Max Crispin; A Radu Aricescu; Veronica T Chang; E Yvonne Jones; David I Stuart; Raymond A Dwek; Simon J Davis; David Harvey
Disruption of alpha-mannosidase processing induces non-canonical hybrid-type glycosylation.
FEBS letters 2007;581(10):1963-8.
2007: Guido C Paesen; Christian Siebold; Karl Harlos; Mick F Peacey; Patricia A Nuttall; David I Stuart
A tick protein with a modified Kunitz fold inhibits human tryptase.
Journal of molecular biology 2007;368(4):1172-86.
2007: Deborah Hatherley; Karl Harlos; D Cameron Dunlop; David I Stuart; A Neil Barclay
The structure of the macrophage signal regulatory protein alpha (SIRPalpha) inhibitory receptor reveals a binding face reminiscent of that used by T cell receptors.
The Journal of biological chemistry 2007;282(19):14567-75.
2007: Pojchong Chotiyarnwong; Guillaume Stewart-Jones; Michael J Tarry; Wanwisa Dejnirattisai; Christian Siebold; Michael Koch; David I Stuart; Karl Harlos; Prida Malasit; Gavin Screaton; Juthathip Mongkolsapaya; E Yvonne Jones
Humidity control as a strategy for lattice optimization applied to crystals of HLA-A*1101 complexed with variant peptides from dengue virus.
Acta crystallographica. Section F, Structural biology and crystallization communications 2007;63(Pt 5):386-92.
2007: Geoff Sutton; Jonathan M Grimes; David I Stuart; Polly Roy
Bluetongue virus VP4 is an RNA-capping assembly line.
Nature structural & molecular biology 2007;14(5):449-51.
2007: Robert J C Gilbert; Yulya Gordiyenko; Tobias von der Haar; Andreas F-P Sonnen; Gregor Hofmann; Maria Nardelli; David I Stuart; John E G McCarthy
Reconfiguration of yeast 40S ribosomal subunit domains by the translation initiation multifactor complex.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(14):5788-93.
2007: Jelena Jovanovic; Junichi Takagi; Laurence Choulier; Nicola G A Abrescia; David I Stuart; Philip van der Merwe; Helen J Mardon; Penny A Handford
alphaVbeta6 is a novel receptor for human fibrillin-1. Comparative studies of molecular determinants underlying integrin-rgd affinity and specificity.
The Journal of biological chemistry 2007;282(9):6743-51.
2007: Veronica T Chang; Max Crispin; A Radu Aricescu; David Harvey; Joanne E Nettleship; Janet A Fennelly; Chao Yu; Kent S Boles; Edward J Evans; David I Stuart; Raymond A Dwek; E Yvonne Jones; Raymond J Owens; Simon J Davis
Glycoprotein structural genomics: solving the glycosylation problem.
Structure (London, England : 1993) 2007;15(3):267-73.
2007: Christoph Meier; Lester G Carter; Graeme Winter; Raymond J Owens; David I Stuart; Robert M Esnouf
Structure of 5-formyltetrahydrofolate cyclo-ligase from Bacillus anthracis (BA4489).
Acta crystallographica. Section F, Structural biology and crystallization communications 2007;63(Pt 3):168-72.
2007: Nick S Berrow; David Alderton; Sarah Sainsbury; Joanne E Nettleship; Rene Assenberg; Nahid Rahman; David I Stuart; Raymond J Owens
A versatile ligation-independent cloning method suitable for high-throughput expression screening applications.
Nucleic acids research 2007;35(6):e45.
2006: Paula S Salgado; Minni R L Koivunen; Eugene V Makeyev; Dennis H Bamford; David I Stuart; Jonathan M Grimes
The structure of an RNAi polymerase links RNA silencing and transcription.
PLoS biology 2006;4(12):e434.
2006: thomas walter; Christoph Meier; Rene Assenberg; Kin-Fai Au; Jingshan Ren; Anil Verma; Joanne E Nettleship; Raymond J Owens; David I Stuart; Jonathan M Grimes
Lysine methylation as a routine rescue strategy for protein crystallization.
Structure (London, England : 1993) 2006;14(11):1617-22.
2006: K Au; Nick S Berrow; Elena V Blagova; Ian W Boucher; M P Boyle; James A Brannigan; Lester G Carter; T Dierks; G Folkers; Rosa Grenha; Karl Harlos; Robert Kaptein; Anne K Kalliomaa; Vladimir M Levdikov; Christoph Meier; N Milioti; O Moroz; Axel Muller; Raymond J Owens; N Rzechorzek; Sarah Sainsbury; David I Stuart; thomas walter; David G Waterman; Anthony J Wilkinson; Keith S Wilson; Nathan R Zaccai; Robert M Esnouf; Mark J Fogg
Application of high-throughput technologies to a structural proteomics-type analysis of Bacillus anthracis.
Acta crystallographica. Section D, Biological crystallography 2006;62(Pt 10):1267-75.
2006: Alison Burman; Stuart Clark; Nicola G A Abrescia; Elizabeth Fry; David I Stuart; Terry Jackson
Specificity of the VP1 GH loop of Foot-and-Mouth Disease virus for alphav integrins.
Journal of virology 2006;80(19):9798-810.
2006: Edward J Evans; Mónica A A Castro; Ronan O'Brien; Alice Kearney; Heather Walsh; Lisa M Sparks; Michael G Tucknott; Elizabeth A Davies; Alexandre M Carmo; Philip van der Merwe; David I Stuart; E Yvonne Jones; John E Ladbury; Shinji Ikemizu; Simon J Davis
Crystal structure and binding properties of the CD2 and CD244 (2B4)-binding protein, CD48.
The Journal of biological chemistry 2006;281(39):29309-20.
2006: Christoph Meier; A Radu Aricescu; Rene Assenberg; Robin T Aplin; Robert J C Gilbert; Jonathan M Grimes; David I Stuart
The crystal structure of ORF-9b, a lipid binding protein from the SARS coronavirus.
Structure (London, England : 1993) 2006;14(7):1157-65.
2006: Olivier Namy; Stephen J Moran; David I Stuart; Robert J C Gilbert; Ian Brierley
A mechanical explanation of RNA pseudoknot function in programmed ribosomal frameshifting.
Nature 2006;441(7090):244-7.
2006: David I Stuart; Jonathan M Grimes
Structural studies on orbivirus proteins and particles.
Current topics in microbiology and immunology 2006;309():221-44.
2006: Robert M Esnouf; Christopher A Love; Karl Harlos; David I Stuart; E Yvonne Jones
Structure determination of human semaphorin 4D as an example of the use of MAD in non-optimal cases.
Acta crystallographica. Section D, Biological crystallography 2006;62(Pt 1):108-15.
2005: Dennis H Bamford; Jonathan M Grimes; David I Stuart
What does structure tell us about virus evolution?
Current opinion in structural biology 2005;15(6):655-63.
2005: Christian Siebold; Nick S Berrow; thomas walter; Karl Harlos; Raymond J Owens; David I Stuart; Jonathan R Terman; Alex L Kolodkin; R Jeroen Pasterkamp; E Yvonne Jones
High-resolution structure of the catalytic region of MICAL (molecule interacting with CasL), a multidomain flavoenzyme-signaling molecule.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(46):16836-41.
2005: Robert J C Gilbert; Lucy P Beales; Donatienne Blond; Martha N Simon; Beth Y Lin; Francis V Chisari; David I Stuart; David J Rowlands
Hepatitis B small surface antigen particles are octahedral.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(41):14783-8.
2005: Janet Newman; David Egan; thomas walter; Ran Meged; Ian M Berry; Marouane Ben Jelloul; Joel Sussman; David I Stuart; Anastassis Perraks
Towards rationalization of crystallization screening for small- to medium-sized academic laboratories: the PACT/JCSG+ strategy.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 10):1426-31.
2005: Karin Anduleit; Geoff Sutton; Jonathan M Diprose; Peter P C Mertens; Jonathan M Grimes; David I Stuart
Crystal lattice as biological phenotype for insect viruses.
Protein science : a publication of the Protein Society 2005;14(10):2741-3.
2005: Christoph Meier; erika mancini; Dennis H Bamford; Martin A Walsh; David I Stuart; Jonathan M Grimes
Overcoming the false-minima problem in direct methods: structure determination of the packaging enzyme P4 from bacteriophage phi13.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 9):1238-44.
2005: Nicola G A Abrescia; Hanna M Kivelä; Jonathan M Grimes; Jaana K H Bamford; Dennis H Bamford; David I Stuart
Preliminary crystallographic analysis of the major capsid protein P2 of the lipid-containing bacteriophage PM2.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 8):762-5.
2005: Elizabeth Fry; John W I Newman; Stephen Curry; Saloua Najjam; Terry Jackson; Wendy Blakemore; Susan M Lea; Laura Miller; Alison Burman; Andrew M Q King; David I Stuart
Structure of Foot-and-mouth disease virus serotype A10 61 alone and complexed with oligosaccharide receptor: receptor conservation in the face of antigenic variation.
The Journal of general virology 2005;86(Pt 7):1909-20.
2005: Nigel P Ferris; Nicola G A Abrescia; David I Stuart; Terry Jackson; Alison Burman; Donald P King; David J Paton
Utility of recombinant integrin alpha v beta6 as a capture reagent in immunoassays for the diagnosis of foot-and-mouth disease.
Journal of virological methods 2005;127(1):69-79.
2005: thomas walter; Jonathan M Diprose; Chris J Mayo; Christian Siebold; Mike G Pickford; Lester Carter; Geoffrey C Sutton; Nick S Berrow; James Brown; Ian M Berry; Guillaume Stewart-Jones; Jonathan M Grimes; David K Stammers; Robert M Esnouf; E Yvonne Jones; Raymond J Owens; David I Stuart; Karl Harlos
A procedure for setting up high-throughput nanolitre crystallization experiments. Crystallization workflow for initial screening, automated storage, imaging and optimization.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 6):651-7.
2005: Edward J Evans; Robert M Esnouf; Raquel Manso-Sancho; Robert J C Gilbert; John R James; Chao Yu; Janet A Fennelly; Cheryl Vowles; Thomas Hanke; Björn Walse; Thomas Hünig; Poul Sørensen; David I Stuart; Simon J Davis
Crystal structure of a soluble CD28-Fab complex.
Nature immunology 2005;6(3):271-9.
2005: Christopher J Mayo; Jonathan M Diprose; thomas walter; Ian M Berry; Julie Wilson; Raymond J Owens; E Yvonne Jones; Karl Harlos; David I Stuart; Robert M Esnouf
Benefits of automated crystallization plate tracking, imaging, and analysis.
Structure (London, England : 1993) 2005;13(2):175-82.
2005: Minni R L Laurila; Paula S Salgado; David I Stuart; Jonathan M Grimes; Dennis H Bamford
Back-priming mode of phi6 RNA-dependent RNA polymerase.
The Journal of general virology 2005;86(Pt 2):521-6.
2005: Elizabeth Fry; David I Stuart; D J Rowlands
The structure of foot-and-mouth disease virus.
Current topics in microbiology and immunology 2005;288():71-101.
2005: Fauziah Mohd Jaafar; Houssam Attoui; Mohammad W Bahar; Christian Siebold; Geoff Sutton; Peter P C Mertens; Philippe de Micco; David I Stuart; Jonathan M Grimes; Xavier de Lamballerie
The structure and function of the outer coat protein VP9 of Banna virus.
Structure (London, England : 1993) 2005;13(1):17-28.
2005: Minni R L Laurila; Paula S Salgado; Eugene V Makeyev; Joanne Nettelship; David I Stuart; Jonathan M Grimes; Dennis H Bamford
Gene silencing pathway RNA-dependent RNA polymerase of Neurospora crassa: yeast expression and crystallization of selenomethionated QDE-1 protein.
Journal of structural biology 2005;149(1):111-5.
2005: Paula S Salgado; Martin A Walsh; Minni R L Laurila; David I Stuart; Jonathan M Grimes
Going soft and SAD with manganese.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 1):108-11.
2004: George A Freeman; C Webster Andrews Iii; Andrew L Hopkins; Gina S Lowell; Lee T Schaller; Jill R Cowan; Stephen S Gonzales; George W Koszalka; Richard J Hazen; Lawrence R Boone; Robert G Ferris; Katrina L Creech; Grace B Roberts; Steven A Short; Kurt Weaver; David J Reynolds; John Milton; Jingshan Ren; David I Stuart; David K Stammers; Joseph H Chan
Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 2.
Journal of medicinal chemistry 2004;47(24):5923-36.
2004: Andrew L Hopkins; Jingshan Ren; John Milton; Richard J Hazen; Joseph H Chan; David I Stuart; David K Stammers
Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1.
Journal of medicinal chemistry 2004;47(24):5912-22.
2004: Joseph J B Cockburn; Nicola G A Abrescia; Jonathan M Grimes; Geoffrey C Sutton; Jonathan M Diprose; James M Benevides; George Thomas; Jaana K H Bamford; Dennis H Bamford; David I Stuart
Membrane structure and interactions with protein and DNA in bacteriophage PRD1.
Nature 2004;432(7013):122-5.
2004: Nicola G A Abrescia; Joseph J B Cockburn; Jonathan M Grimes; Geoffrey C Sutton; Jonathan M Diprose; Sarah J Butcher; Stephen D Fuller; Carmen San Martín; Roger M Burnett; David I Stuart; Dennis H Bamford; Jaana K H Bamford
Insights into assembly from structural analysis of bacteriophage PRD1.
Nature 2004;432(7013):68-74.
2004: erika mancini; Denis E Kainov; Jonathan M Grimes; Roman Tuma; Dennis H Bamford; David I Stuart
Atomic snapshots of an RNA packaging motor reveal conformational changes linking ATP hydrolysis to RNA translocation.
Cell 2004;118(6):743-55.
2004: Robert J C Gilbert; Paola Fucini; Sean connell; Stephen D Fuller; Knud H Nierhaus; Carol V Robinson; Christopher M Dobson; David I Stuart
Three-dimensional structures of translating ribosomes by Cryo-EM.
Molecular cell 2004;14(1):57-66.
2004: Stephen S J Lee; Vroni Knott; Jelena Jovanović; Karl Harlos; Jonathan M Grimes; Laurence Choulier; Helen J Mardon; David I Stuart; Penny A Handford
Structure of the integrin binding fragment from fibrillin-1 gives new insights into microfibril organization.
Structure (London, England : 1993) 2004;12(4):717-29.
2004: erika mancini; Denis E Kainov; Hui Wei; Paul Gottlieb; Roman Tuma; Dennis H Bamford; David I Stuart; Jonathan M Grimes
Production, crystallization and preliminary X-ray crystallographic studies of the bacteriophage phi 12 packaging motor.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 3):588-90.
2004: Geoff Sutton; Elizabeth Fry; Lester Carter; Sarah Sainsbury; thomas walter; Joanne E Nettleship; Nick S Berrow; Ray Owens; Robert Gilbert; Andrew Davidson; Stuart G Siddell; Leo Poon; Jonathan M Diprose; David Alderton; Martin Walsh; Jonathan M Grimes; David I Stuart
The nsp9 replicase protein of SARS-coronavirus, structure and functional insights.
Structure (London, England : 1993) 2004;12(2):341-53.
2004: Paula S Salgado; Eugene V Makeyev; Sarah J Butcher; Dennis H Bamford; David I Stuart; Jonathan M Grimes
The structural basis for RNA specificity and Ca2+ inhibition of an RNA-dependent RNA polymerase.
Structure (London, England : 1993) 2004;12(2):307-16.
2003: erika mancini; Jonathan M Grimes; Robyn Malby; Geoffrey C Sutton; Denis E Kainov; Jarmo T Juuti; Eugene V Makeyev; Roman Tuma; Dennis H Bamford; David I Stuart
Order and disorder in crystals of hexameric NTPases from dsRNA bacteriophages.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 12):2337-41.
2003: Christopher A Love; Karl Harlos; Nasim Mavaddat; Simon J Davis; David I Stuart; E Yvonne Jones; Robert M Esnouf
The ligand-binding face of the semaphorins revealed by the high-resolution crystal structure of SEMA4D.
Nature structural biology 2003;10(10):843-8.
2003: Guillaume Stewart-Jones; Andrew J McMichael; John I Bell; David I Stuart; E Yvonne Jones
A structural basis for immunodominant human T cell receptor recognition.
Nature immunology 2003;4(7):657-63.
2003: Elizabeth Fry; Nick J Knowles; John W I Newman; Ginette Wilsden; Zihe Rao; Andrew M Q King; David I Stuart
Crystal structure of Swine vesicular disease virus and implications for host adaptation.
Journal of virology 2003;77(9):5475-86.
2003: Joseph J B Cockburn; Jaana K H Bamford; Jonathan M Grimes; Dennis H Bamford; David I Stuart
Crystallization of the membrane-containing bacteriophage PRD1 in quartz capillaries by vapour diffusion.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 3):538-40.
2003: Robert J C Gilbert; Jonathan M Grimes; David I Stuart
Hybrid vigor: hybrid methods in viral structure determination.
Advances in protein chemistry 2003;64():37-91.
2003: Louise Bird; Philip P Chamberlain; Guillaume Stewart-Jones; Jingshan Ren; David I Stuart; David K Stammers
Cloning, expression, purification, and crystallisation of HIV-2 reverse transcriptase.
Protein expression and purification 2003;27(1):12-8.
2002: Jingshan Ren; Louise Bird; Philip P Chamberlain; Guillaume Stewart-Jones; David I Stuart; David K Stammers
Structure of HIV-2 reverse transcriptase at 2.35-A resolution and the mechanism of resistance to non-nucleoside inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):14410-5.
2002: Heather L E Lang; Helle Jacobsen; Shinji Ikemizu; Christina Andersson; Karl Harlos; Lars Madsen; Peter Hjorth; Leif Sondergaard; Arne Svejgaard; Kai W Wucherpfennig; David I Stuart; John I Bell; E Yvonne Jones; Lars Fugger
A functional and structural basis for TCR cross-reactivity in multiple sclerosis.
Nature immunology 2002;3(10):940-3.
2002: Philip P Chamberlain; Jingshan Ren; Charles E Nichols; L Douglas; Johan Lennerstrand; Brendan Larder; David I Stuart; David K Stammers
Crystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215.
Journal of virology 2002;76(19):10015-9.
2002: Jonathan M Diprose; Jonathan M Grimes; Geoffrey C Sutton; JN Burroughs; A Meyer; Sushila Maan; Peter P C Mertens; David I Stuart
The core of bluetongue virus binds double-stranded RNA.
Journal of virology 2002;76(18):9533-6.
2002: Jaana K H Bamford; Joseph J B Cockburn; Jonathan M Diprose; Jonathan M Grimes; Geoff Sutton; David I Stuart; Dennis H Bamford
Diffraction quality crystals of PRD1, a 66-MDa dsDNA virus with an internal membrane.
Journal of structural biology 2002;139(2):103-12.
2002: Alison V Collins; Douglas W Brodie; Robert J C Gilbert; Andrea Iaboni; Raquel Manso-Sancho; Björn Walse; David I Stuart; Philip van der Merwe; Simon J Davis
The interaction properties of costimulatory molecules revisited.
Immunity 2002;17(2):201-10.
2002: Amanda D Stuart; Thomas A McKee; Pamela A Williams; Chris Harley; Shuo Shen; David I Stuart; T David K Brown; Susan M Lea
Determination of the structure of a decay accelerating factor-binding clinical isolate of echovirus 11 allows mapping of mutants with altered receptor requirements for infection.
Journal of virology 2002;76(15):7694-704.
2002: Wai-Ching Hon; Michael I Wilson; Karl Harlos; Timothy D W Claridge; Christopher J Schofield; Christopher W Pugh; Patrick H Maxwell; Peter J Ratcliffe; David I Stuart; E Yvonne Jones
Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.
Nature 2002;417(6892):975-8.
2002: Dennis H Bamford; Roger M Burnett; David I Stuart
Evolution of viral structure.
Theoretical population biology 2002;61(4):461-70.
2002: Hideki Hatanaka; Oleg Iourin; Zihe Rao; Elizabeth Fry; Alan J Kingsman; David I Stuart
Structure of equine infectious anemia virus matrix protein.
Journal of virology 2002;76(4):1876-83.
2001: Jonathan M Diprose; JN Burroughs; Geoffrey C Sutton; A Goldsmith; Patrice Gouet; Robyn Malby; I Overton; S Ziéntara; Peter P C Mertens; David I Stuart; Jonathan M Grimes
Translocation portals for the substrates and products of a viral transcription complex: the bluetongue virus core.
The EMBO journal 2001;20(24):7229-39.
2001: Jingshan Ren; C Nichols; Louise Bird; Philip P Chamberlain; Kurt Weaver; S Short; David I Stuart; David K Stammers
Structural mechanisms of drug resistance for mutations at codons 181 and 188 in HIV-1 reverse transcriptase and the improved resilience of second generation non-nucleoside inhibitors.
Journal of molecular biology 2001;312(4):795-805.
2001: Joseph H Chan; J S Hong; R N Hunter ; Gloria Faye Orr; Jill R Cowan; D B Sherman; S M Sparks; B E Reitter; C Webster Andrews; Richard J Hazen; Marty St Clair; Lawrence R Boone; Robert G Ferris; Katrina L Creech; Grace B Roberts; Steven A Short; Kurt Weaver; R J Ott; Jingshan Ren; A Hopkins; David I Stuart; David K Stammers
2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1.
Journal of medicinal chemistry 2001;44(12):1866-82.
2001: Simon J Davis; Shinji Ikemizu; Alison V Collins; Janet A Fennelly; Karl Harlos; E Yvonne Jones; David I Stuart
Crystallization and functional analysis of a soluble deglycosylated form of the human costimulatory molecule B7-1.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 4):605-8.
2001: Sarah J Butcher; Jonathan M Grimes; Eugene V Makeyev; Dennis H Bamford; David I Stuart
A mechanism for initiating RNA-dependent RNA polymerization.
Nature 2001;410(6825):235-40.
2001: Dennis H Bamford; R J Gilbert; Jonathan M Grimes; David I Stuart
Macromolecular assemblies: greater than their parts.
Current opinion in structural biology 2001;11(1):107-13.
2000: Sarah J Butcher; Eugene V Makeyev; Jonathan M Grimes; David I Stuart; Dennis H Bamford
Crystallization and preliminary X-ray crystallographic studies on the bacteriophage phi6 RNA-dependent RNA polymerase.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 11):1473-5.
2000: Jingshan Ren; John Milton; Kurt L Weaver; Steven A Short; David I Stuart; David K Stammers
Structural basis for the resilience of efavirenz (DMP-266) to drug resistance mutations in HIV-1 reverse transcriptase.
Structure (London, England : 1993) 2000;8(10):1089-94.
2000: Katsumi Maenaka; Taeko Maenaka; H Tomiyama; M Takiguchi; David I Stuart; E Yvonne Jones
Nonstandard peptide binding revealed by crystal structures of HLA-B*5101 complexed with HIV immunodominant epitopes.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(6):3260-7.
2000: Nasim Mavaddat; D W Mason; P D Atkinson; Edward J Evans; Robert J C Gilbert; David I Stuart; Janet A Fennelly; A Neil Barclay; Simon J Davis; Marion H Brown
Signaling lymphocytic activation molecule (CDw150) is homophilic but self-associates with very low affinity.
The Journal of biological chemistry 2000;275(36):28100-9.
2000: George F Gao; Benjamin E Willcox; Jessica R Wyer; Jonathan M Boulter; Christopher A O'Callaghan; Katsumi Maenaka; David I Stuart; E Yvonne Jones; Philip van der Merwe; John I Bell; Bent K Jakobsen
Classical and nonclassical class I major histocompatibility complex molecules exhibit subtle conformational differences that affect binding to CD8alphaalpha.
The Journal of biological chemistry 2000;275(20):15232-8.
2000: Jingshan Ren; C Nichols; Louise Bird; T Fujiwara; H Sugimoto; David I Stuart; David K Stammers
Binding of the second generation non-nucleoside inhibitor S-1153 to HIV-1 reverse transcriptase involves extensive main chain hydrogen bonding.
The Journal of biological chemistry 2000;275(19):14316-20.
2000: Jingshan Ren; Jonathan M Diprose; J Warren; Robert M Esnouf; Louise Bird; S Ikemizu; M Slater; John Milton; Jan Balzarini; David I Stuart; David K Stammers
Phenylethylthiazolylthiourea (PETT) non-nucleoside inhibitors of HIV-1 and HIV-2 reverse transcriptases. Structural and biochemical analyses.
The Journal of biological chemistry 2000;275(8):5633-9.
2000: Shinji Ikemizu; Robert J C Gilbert; Janet A Fennelly; Alison V Collins; Karl Harlos; E Yvonne Jones; David I Stuart; Simon J Davis
Structure and dimerization of a soluble form of B7-1.
Immunity 2000;12(1):51-60.
1999: Andrew L Hopkins; Jingshan Ren; Hiromichi Tanaka; Masanori Baba; M Okamato; David I Stuart; David K Stammers
Design of MKC-442 (emivirine) analogues with improved activity against drug-resistant HIV mutants.
Journal of medicinal chemistry 1999;42(22):4500-5.
1999: Juthathip Mongkolsapaya; J M Grimes; N Chen; Xiao-Ning Xu; David I Stuart; E Yvonne Jones; Gavin Screaton
Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation.
Nature structural biology 1999;6(11):1048-53.
1999: Jonathan M Grimes; Stephen D Fuller; David I Stuart
Complementing crystallography: the role of cryo-electron microscopy in structural biology.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 10):1742-9.
1999: Katsumi Maenaka; T Juji; T Nakayama; Jessica R Wyer; George F Gao; Taeko Maenaka; Nathan R Zaccai; A Kikuchi; T Yabe; K Tokunaga; K Tadokoro; David I Stuart; E Yvonne Jones; Philip van der Merwe
Killer cell immunoglobulin receptors and T cell receptors bind peptide-major histocompatibility complex class I with distinct thermodynamic and kinetic properties.
The Journal of biological chemistry 1999;274(40):28329-34.
1999: Jingshan Ren; Robert M Esnouf; Andrew L Hopkins; David I Stuart; David K Stammers
Crystallographic analysis of the binding modes of thiazoloisoindolinone non-nucleoside inhibitors to HIV-1 reverse transcriptase and comparison with modeling studies.
Journal of medicinal chemistry 1999;42(19):3845-51.
1999: FM Ellard; J Drew; Wendy Blakemore; David I Stuart; Andrew M Q King
Evidence for the role of His-142 of protein 1C in the acid-induced disassembly of foot-and-mouth disease virus capsids.
The Journal of general virology 1999;80 ( Pt 8)():1911-8.
1999: Terry D Butters; Lisa M Sparks; Karl Harlos; Shinji Ikemizu; David I Stuart; E Yvonne Jones; Simon J Davis
Effects of N-butyldeoxynojirimycin and the Lec3.2.8.1 mutant phenotype on N-glycan processing in Chinese hamster ovary cells: application to glycoprotein crystallization.
Protein science : a publication of the Protein Society 1999;8(8):1696-701.
1999: C L Hill; T F Booth; B V Prasad; Jonathan M Grimes; Peter P C Mertens; Geoffrey C Sutton; David I Stuart
The structure of a cypovirus and the functional organization of dsRNA viruses.
Nature structural biology 1999;6(6):565-8.
1999: Patrice Gouet; Jonathan M Diprose; Jonathan M Grimes; Robyn Malby; JN Burroughs; Stéphan Zientara; David I Stuart; Peter P C Mertens
The highly ordered double-stranded RNA genome of bluetongue virus revealed by crystallography.
Cell 1999;97(4):481-90.
1999: Guido C Paesen; P L Adams; Karl Harlos; Patricia A Nuttall; David I Stuart
Tick histamine-binding proteins: isolation, cloning, and three-dimensional structure.
Molecular cell 1999;3(5):661-71.
1999: K Maenaka; T Juji; David I Stuart; E Yvonne Jones
Crystal structure of the human p58 killer cell inhibitory receptor (KIR2DL3) specific for HLA-Cw3-related MHC class I.
Structure (London, England : 1993) 1999;7(4):391-8.
1999: Shinji Ikemizu; Lisa M Sparks; Philip van der Merwe; Karl Harlos; David I Stuart; E Yvonne Jones; Simon J Davis
Crystal structure of the CD2-binding domain of CD58 (lymphocyte function-associated antigen 3) at 1.8-A resolution.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(8):4289-94.
1999: A Sharma; Janet Askari; M J Humphries; E Yvonne Jones; David I Stuart
Crystal structure of a heparin- and integrin-binding segment of human fibronectin.
The EMBO journal 1999;18(6):1468-79.
1999: C L Hill; T F Booth; David I Stuart; Peter P C Mertens
Lipofectin increases the specific activity of cypovirus particles for cultured insect cells.
Journal of virological methods 1999;78(1-2):177-89.
1999: Elizabeth Fry; Susan M Lea; Terry Jackson; John W I Newman; FM Ellard; Wendy Blakemore; R Abu-Ghazaleh; A Samuel; Andrew M Q King; David I Stuart
The structure and function of a foot-and-mouth disease virus-oligosaccharide receptor complex.
The EMBO journal 1999;18(3):543-54.
1998: Susan M Lea; R M Powell; Thomas A McKee; David J Evans; D Brown; David I Stuart; Philip van der Merwe
Determination of the affinity and kinetic constants for the interaction between the human virus echovirus 11 and its cellular receptor, CD55.
The Journal of biological chemistry 1998;273(46):30443-7.
1998: Jingshan Ren; Robert M Esnouf; Andrew L Hopkins; J Warren; J Balzarini; David I Stuart; David K Stammers
Crystal structures of HIV-1 reverse transcriptase in complex with carboxanilide derivatives.
Biochemistry 1998;37(41):14394-403.
1998: Jonathan M Grimes; JN Burroughs; Patrice Gouet; Jonathan M Diprose; Robyn Malby; S Ziéntara; Peter P C Mertens; David I Stuart
The atomic structure of the bluetongue virus core.
Nature 1998;395(6701):470-8.
1998: Robert M Esnouf; Jingshan Ren; E F Garman; D O Somers; CK Ross; E Yvonne Jones; David K Stammers; David I Stuart
Continuous and discontinuous changes in the unit cell of HIV-1 reverse transcriptase crystals on dehydration.
Acta crystallographica. Section D, Biological crystallography 1998;54(Pt 5):938-53.
1998: Jingshan Ren; Robert M Esnouf; Andrew L Hopkins; E Yvonne Jones; I Kirby; J Keeling; CK Ross; B A Larder; David I Stuart; David K Stammers
3'-Azido-3'-deoxythymidine drug resistance mutations in HIV-1 reverse transcriptase can induce long range conformational changes.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(16):9518-23.
1998: Jonathan M Grimes; David I Stuart
Large unit cells and cellular mechanics.
Nature structural biology 1998;5 Suppl():630-4.
1998: Hiromichi Tanaka; R T Walker; Andrew L Hopkins; Jingshan Ren; E Yvonne Jones; K Fujimoto; M Hayashi; T Miyasaka; Masanori Baba; David K Stammers; David I Stuart
Allosteric inhibitors against HIV-1 reverse transcriptase: design and synthesis of MKC-442 analogues having an omega-functionalized acyclic structure.
Antiviral chemistry & chemotherapy 1998;9(4):325-32.
1998: E Yvonne Jones; J Tormo; S W Reid; David I Stuart
Recognition surfaces of MHC class I.
Immunological reviews 1998;163():121-8.
1998: K Maenaka; T Juji; K Tadokoro; K Harlos; David I Stuart; E Yvonne Jones
Crystallization and preliminary diffraction studies of the extracellular region of human p58 killer cell inhibitory receptor (KIR2).
Acta crystallographica. Section D, Biological crystallography 1998;54(Pt 3):433-5.
1998: Christopher A O'Callaghan; Jose Tormo; Benjamin E Willcox; C D Blundell; Bent K Jakobsen; David I Stuart; A J McMichael; John I Bell; E Yvonne Jones
Production, crystallization, and preliminary X-ray analysis of the human MHC class Ib molecule HLA-E.
Protein science : a publication of the Protein Society 1998;7(5):1264-6.
1998: Christopher A O'Callaghan; Jose Tormo; Benjamin E Willcox; Veronique M Braud; Bent K Jakobsen; David I Stuart; Andrew J McMichael; John I Bell; E Yvonne Jones
Structural features impose tight peptide binding specificity in the nonclassical MHC molecule HLA-E.
Molecular cell 1998;1(4):531-41.
1998: David I Stuart; Patrice Gouet; J Grimes; Robyn Malby; Jonathan M Diprose; Stéphan Zientara; JN Burroughs; Peter P C Mertens
Structural studies of orbivirus particles.
Archives of virology. Supplementum 1998;14():235-50.
1997: A Sharma; Zihe Rao; Elizabeth Fry; T Booth; E Yvonne Jones; D J Rowlands; D L Simmons; David I Stuart
Specific interactions between human integrin alpha v beta 3 and chimeric hepatitis B virus core particles bearing the receptor-binding epitope of foot-and-mouth disease virus.
Virology 1997;239(1):150-7.
1997: Terry Jackson; A Sharma; R A Ghazaleh; Wendy Blakemore; FM Ellard; D L Simmons; John W I Newman; David I Stuart; Andrew M Q King
Arginine-glycine-aspartic acid-specific binding by foot-and-mouth disease viruses to the purified integrin alpha(v)beta3 in vitro.
Journal of virology 1997;71(11):8357-61.
1997: Ajit K Basak; Jonathan M Grimes; Patrice Gouet; Polly Roy; David I Stuart
Structures of orbivirus VP7: implications for the role of this protein in the viral life cycle.
Structure (London, England : 1993) 1997;5(7):871-83.
1997: Jonathan M Grimes; J Jakana; M Ghosh; Ajit K Basak; Polly Roy; W Chiu; David I Stuart; B V Prasad
An atomic model of the outer layer of the bluetongue virus core derived from X-ray crystallography and electron cryomicroscopy.
Structure (London, England : 1993) 1997;5(7):885-93.
1997: George F Gao; Jose Tormo; UC Gerth; Jessica R Wyer; Andrew J McMichael; David I Stuart; John I Bell; E Yvonne Jones; Bent K Jakobsen
Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2.
Nature 1997;387(6633):630-4.
1997: Robert M Esnouf; Jingshan Ren; Andrew L Hopkins; CK Ross; E Yvonne Jones; David K Stammers; David I Stuart
Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(8):3984-9.
1996: S W Reid; S McAdam; K J Smith; Paul Klenerman; Christopher A O'Callaghan; Karl Harlos; Bent K Jakobsen; Andrew J McMichael; John I Bell; David I Stuart; E Yvonne Jones
Antagonist HIV-1 Gag peptides induce structural changes in HLA B8.
The Journal of experimental medicine 1996;184(6):2279-86.
1996: Terry Jackson; F M Ellard; R A Ghazaleh; S M Brookes; Wendy Blakemore; A H Corteyn; David I Stuart; John W I Newman; Andrew M Q King
Efficient infection of cells in culture by type O foot-and-mouth disease virus requires binding to cell surface heparan sulfate.
Journal of virology 1996;70(8):5282-7.
1996: Robert Robinson; Czeslaw Radziejewski; David I Stuart; E Yvonne Jones
Crystals of the neurotrophins.
Protein science : a publication of the Protein Society 1996;5(5):973-7.
1996: Andrew L Hopkins; Jingshan Ren; Robert M Esnouf; Benjamin E Willcox; E Yvonne Jones; C Ross; T Miyasaka; R T Walker; Hiromichi Tanaka; David K Stammers; David I Stuart
Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors.
Journal of medicinal chemistry 1996;39(8):1589-600.
1996: S W Reid; K J Smith; Bent K Jakobsen; Christopher A O'Callaghan; H Reyburn; Karl Harlos; David I Stuart; Andrew J McMichael; John I Bell; E Yvonne Jones
Production and crystallization of MHC class I B allele single peptide complexes.
FEBS letters 1996;383(1-2):119-23.
1996: K J Smith; S W Reid; Karl Harlos; Andrew J McMichael; David I Stuart; John I Bell; E Yvonne Jones
Bound water structure and polymorphic amino acids act together to allow the binding of different peptides to MHC class I HLA-B53.
Immunity 1996;4(3):215-28.
1996: K J Smith; S W Reid; David I Stuart; Andrew J McMichael; E Yvonne Jones; John I Bell
An altered position of the alpha 2 helix of MHC class I is revealed by the crystal structure of HLA-B*3501.
Immunity 1996;4(3):203-13.
1995: Z Rao; A S Belyaev; Elizabeth Fry; P Roy; I M Jones; David I Stuart
Crystal structure of SIV matrix antigen and implications for virus assembly.
Nature 1995;378(6558):743-7.
1995: David I Stuart; E Yvonne Jones
Recognition at the cell surface: recent structural insights.
Current opinion in structural biology 1995;5(6):735-43.
1995: Robert Robinson; L M Grey; D Staunton; David I Stuart; J K Heath; E Yvonne Jones
The crystal structure of murine leukemia inhibitory factor.
Annals of the New York Academy of Sciences 1995;762():179-87; discussion 187-8.
1995: G Spraggon; C Phillips; U K Nowak; C P Ponting; D Saunders; Christopher M Dobson; David I Stuart; E Yvonne Jones
The crystal structure of the catalytic domain of human urokinase-type plasminogen activator.
Structure (London, England : 1993) 1995;3(7):681-91.
1995: JN Burroughs; Jonathan M Grimes; Peter P C Mertens; David I Stuart
Crystallization and preliminary X-ray analysis of the core particle of bluetongue virus.
Virology 1995;210(1):217-20.
1995: Robert Robinson; Czeslaw Radziejewski; David I Stuart; E Yvonne Jones
Structure of the brain-derived neurotrophic factor/neurotrophin 3 heterodimer.
Biochemistry 1995;34(13):4139-46.
1995: E Yvonne Jones; Karl Harlos; Matthew J Bottomley; Robert Robinson; Paul C Driscoll; R M Edwards; John M Clements; T J Dudgeon; David I Stuart
Crystal structure of an integrin-binding fragment of vascular cell adhesion molecule-1 at 1.8 A resolution.
Nature 1995;373(6514):539-44.
1995: Simon J Davis; Elizabeth A Davies; A Neil Barclay; S Daenke; D L Bodian; E Yvonne Jones; David I Stuart; Terry D Butters; Raymond A Dwek; Philip van der Merwe
Ligand binding by the immunoglobulin superfamily recognition molecule CD2 is glycosylation-independent.
The Journal of biological chemistry 1995;270(1):369-75.
1995: S Curry; C C Abrams; Elizabeth Fry; J C Crowther; G J Belsham; David I Stuart; Andrew M Q King
Viral RNA modulates the acid sensitivity of foot-and-mouth disease virus capsids.
Journal of virology 1995;69(1):430-8.
1994: Ajit K Basak; David I Stuart; T Nikura; D H Bishop; D C Kelly; A Fearn; Richard Titball
Purification, crystallization and preliminary X-ray diffraction studies of alpha-toxin of Clostridium perfringens.
Journal of molecular biology 1994;244(5):648-50.
1994: Matthew J Bottomley; Robert Robinson; Paul C Driscoll; Karl Harlos; David I Stuart; R T Aplin; John M Clements; E Yvonne Jones; T J Dudgeon
Crystallization and preliminary X-ray diffraction characterisation of both a native and selenomethionyl VLA-4 binding fragment of VCAM-1.
Journal of molecular biology 1994;244(4):464-8.
1994: Karl Harlos; D M Martin; D P O'Brien; E Yvonne Jones; David I Stuart; I Polikarpov; A Miller; E G Tuddenham; C W Boys
Crystal structure of the extracellular region of human tissue factor.
Nature 1994;370(6491):662-6.
1994: D L Bodian; E Yvonne Jones; Karl Harlos; David I Stuart; Simon J Davis
Crystal structure of the extracellular region of the human cell adhesion molecule CD2 at 2.5 A resolution.
Structure (London, England : 1993) 1994;2(8):755-66.
1994: K Ravi Acharya; David I Stuart; D C Phillips; H A McKenzie; C G Teahan
Models of the three-dimensional structures of echidna, horse, and pigeon lysozymes: calcium-binding lysozymes and their relationship with alpha-lactalbumins.
Journal of protein chemistry 1994;13(6):569-84.
1994: Robert Robinson; L M Grey; D Staunton; H Vankelecom; AB Vernallis; J F Moreau; David I Stuart; J K Heath; E Yvonne Jones
The crystal structure and biological function of leukemia inhibitory factor: implications for receptor binding.
Cell 1994;77(7):1101-16.
1994: A S Tavernor; Julia H Kydd; D L Bodian; E Yvonne Jones; David I Stuart; Simon J Davis; Geoffrey W Butcher
Expression cloning of an equine T-lymphocyte glycoprotein CD2 cDNA. Structure-based analysis of conserved sequence elements.
European journal of biochemistry / FEBS 1994;219(3):969-76.
1994: K Ravi Acharya; E F Passalacqua; E Yvonne Jones; Karl Harlos; David I Stuart; R D Brehm; Howard S Tranter
Structural basis of superantigen action inferred from crystal structure of toxic-shock syndrome toxin-1.
Nature 1994;367(6458):94-7.
1993: Ajit K Basak; D P Baker; C A Fewson; David I Stuart
Preliminary crystallographic study of D(-)-mandelate dehydrogenase from Rhodotorula graminis.
Journal of molecular biology 1993;233(4):781-3.
1993: Simon J Davis; Michael J Puklavec; D A Ashford; Karl Harlos; E Yvonne Jones; David I Stuart; A F Williams
Expression of soluble recombinant glycoproteins with predefined glycosylation: application to the crystallization of the T-cell glycoprotein CD2.
Protein engineering 1993;6(2):229-32.
1992: A K Basak; David I Stuart; P Roy
Preliminary crystallographic study of bluetongue virus capsid protein, VP7.
Journal of molecular biology 1992;228(2):687-9.
1992: E Yvonne Jones; Simon J Davis; A F Williams; Karl Harlos; David I Stuart
Crystal structure at 2.8 A resolution of a soluble form of the cell adhesion molecule CD2.
Nature 1992;360(6401):232-9.
1992: E Yvonne Jones; David I Stuart; N P Walker
Crystal structure of TNF.
Immunology series 1992;56():93-127.
1991: E Yvonne Jones; N P Walker; David I Stuart
Methodology employed for the structure determination of tumour necrosis factor, a case of high non-crystallographic symmetry.
Acta crystallographica. Section A, Foundations of crystallography 1991;47 ( Pt 6)():753-70.
1991: K Ravi Acharya; J S Ren; David I Stuart; D C Phillips; Roger Fenna
Crystal structure of human alpha-lactalbumin at 1.7 A resolution.
Journal of molecular biology 1991;221(2):571-81.
1990: K Ravi Acharya; David I Stuart; D C Phillips; H A Scheraga
A critical evaluation of the predicted and X-ray structures of alpha-lactalbumin.
Journal of protein chemistry 1990;9(5):549-63.
1990: E Yvonne Jones; David I Stuart; N P Walker
The three-dimensional structure of tumour necrosis factor.
Progress in clinical and biological research 1990;349():321-7.
1990: E Yvonne Jones; David I Stuart; N P Walker
The structure of tumour necrosis factor--implications for biological function.
Journal of cell science. Supplement 1990;13():11-8.
1989: K Ravi Acharya; David I Stuart; N P Walker; M Lewis; D C Phillips
Refined structure of baboon alpha-lactalbumin at 1.7 A resolution. Comparison with C-type lysozyme.
Journal of molecular biology 1989;208(1):99-127.
1989: Nikos G Oikonomakos; K Ravi Acharya; A E Melpidou; David I Stuart; Louise N Johnson
The binding of beta-glycerophosphate to glycogen phosphorylase b in the crystal.
Archives of biochemistry and biophysics 1989;270(1):62-8.
1989: E Yvonne Jones; David I Stuart; N P Walker
Structure of tumour necrosis factor.
Nature 1989;338(6212):225-8.
1988: Stephen R Sprang; K R Acharya; Elizabeth J Goldsmith; David I Stuart; K Varvill; Robert J Fletterick; N B Madsen; Louise N Johnson
Structural changes in glycogen phosphorylase induced by phosphorylation.
Nature 1988;336(6196):215-21.
1988: Nikos G Oikonomakos; K Ravi Acharya; David I Stuart; A E Melpidou; P J McLaughlin; Louise N Johnson
Uridine(5')diphospho(1)-alpha-D-glucose. A binding study to glycogen phosphorylase b in the crystal.
European journal of biochemistry / FEBS 1988;173(3):569-78.
1987: Nikos G Oikonomakos; Louise N Johnson; K Ravi Acharya; David I Stuart; David Barford; Janos Hajdu; K M Varvill; A E Melpidou; T Papageorgiou; D J Graves
Pyridoxal phosphate site in glycogen phosphorylase b: structure in native enzyme and in three derivatives with modified cofactors.
Biochemistry 1987;26(25):8381-9.
1987: Louise N Johnson; K Ravi Acharya; David I Stuart; David Barford; Nikos G Oikonomakos; Janos Hajdu; K M Varvill
Phosphate-recognition sites in catalysis and control of glycogen phosphorylase b.
Biochemical Society transactions 1987;15(5):1001-5.
1987: D C Phillips; K Ravi Acharya; H H Handoll; David I Stuart
From lysozyme to alpha-lactalbumin: protein engineering and evolution.
Biochemical Society transactions 1987;15(4):737-44.
1987: S G Smith; M Lewis; R Aschaffenburg; Roger Fenna; I A Wilson; M Sundaralingam; David I Stuart; D C Phillips
Crystallographic analysis of the three-dimensional structure of baboon alpha-lactalbumin at low resolution. Homology with lysozyme.
The Biochemical journal 1987;242(2):353-60.
1986: David I Stuart; K Ravi Acharya; N P Walker; S G Smith; M Lewis; D C Phillips
Alpha-lactalbumin possesses a novel calcium binding loop.
Nature 1986;324(6092):84-7.