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George Studzinski
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23
Wang, Xuening
8
Wang, QM
7
Danilenko, Michael
5
Harrison, Jonathan
5
Harrison, Lawrence
5
Ji, Yan
5
Wang, Qing
5
Garay, Edward
4
Uskokovic, Milan
3
Sharoni, Yoav
3
Coffman, Frederick
3
Gardner, Jeffrey
3
Kutner, Andrzej
3
Levy, Joseph
3
Luo, X
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All Publications
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2009: Chen-Deutsch Xiangwen; Garay Edward; Zhang Jing; Harrison Jonathan S; Studzinski George P
c-Jun N-terminal kinase 2 (JNK2) antagonizes the signaling of differentiation by JNK1 in human myeloid leukemia cells resistant to vitamin D.
Leukemia research 2009;33(10):1372-8.
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2009: Wang Xuening; Gocek Elzbieta; Liu Chang-Gong; Studzinski George P
MicroRNAs181 regulate the expression of p27Kip1 in human myeloid leukemia cells induced to differentiate by 1,25-dihydroxyvitamin D3.
Cell cycle (Georgetown, Tex.) 2009;8(5):736-41.
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2009: Gocek Elzbieta; Studzinski George P
Vitamin D and differentiation in cancer.
Critical reviews in clinical laboratory sciences 2009;46(4):190-209.
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2008: Wang Xuening; Patel Rahul; Studzinski George P
hKSR-2, a vitamin D-regulated gene, inhibits apoptosis in arabinocytosine-treated HL60 leukemia cells.
Molecular cancer therapeutics 2008;7(9):2798-806.
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2008: Jamshidi Farnaz; Zhang Jing; Harrison Jonathan S; Wang Xuening; Studzinski George P
Induction of differentiation of human leukemia cells by combinations of COX inhibitors and 1,25-dihydroxyvitamin D3 involves Raf1 but not Erk 1/2 signaling.
Cell cycle (Georgetown, Tex.) 2008;7(7):917-24.
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2008: Shabtay Ayelet; Sharabani Hagar; Barvish Zeev; Kafka Michael; Amichay Doron; Levy Joseph; Sharoni Yoav; Uskokovic Milan R; Studzinski George P; Danilenko Michael
Synergistic antileukemic activity of carnosic acid-rich rosemary extract and the 19-nor Gemini vitamin D analogue in a mouse model of systemic acute myeloid leukemia.
Oncology 2008;75(3-4):203-14.
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2007: Garay Edward; Donnelly Robert; Wang Xuening; Studzinski George P
Resistance to 1,25D-induced differentiation in human acute myeloid leukemia HL60-40AF cells is associated with reduced transcriptional activity and nuclear localization of the vitamin D receptor.
Journal of cellular physiology 2007;213(3):816-25.
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2007: Wang Xuening; Wang Tian-Tian; White John H; Studzinski George P
Expression of human kinase suppressor of Ras 2 (hKSR-2) gene in HL60 leukemia cells is directly upregulated by 1,25-dihydroxyvitamin D(3) and is required for optimal cell differentiation.
Experimental cell research 2007;313(14):3034-45.
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2007: Garay Edward; Jankowski Pawel; Lizano Paulo; Marczak Stanislaw; Maehr Hubert; Adorini Luciano; Uskokovic Milan R; Studzinski George P
Calcitriol derivatives with two different side-chains at C-20. Part 4: further chain modifications that alter VDR-dependent monocytic differentiation potency in human leukemia cells.
Bioorganic & medicinal chemistry 2007;15(13):4444-55.
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2007: Zhang Jing; Posner Gary H; Danilenko Michael; Studzinski George P
Differentiation-inducing potency of the seco-steroid JK-1624F2-2 can be increased by combination with an antioxidant and a p38MAPK inhibitor which upregulates the JNK pathway.
The Journal of steroid biochemistry and molecular biology 2007;105(1-5):140-9.
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2006: Wang Xuening; Studzinski George P
Raf-1 signaling is required for the later stages of 1,25-dihydroxyvitamin D3-induced differentiation of HL60 cells but is not mediated by the MEK/ERK module.
Journal of cellular physiology 2006;209(2):253-60.
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2006: Wang X; Wang T-T; White J H; Studzinski G P
Induction of kinase suppressor of RAS-1(KSR-1) gene by 1, alpha25-dihydroxyvitamin D3 in human leukemia HL60 cells through a vitamin D response element in the 5'-flanking region.
Oncogene 2006;25(53):7078-85.
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2006: Marcinkowska Ewa; Garay Edward; Gocek Elzbieta; Chrobak Agnieszka; Wang Xuening; Studzinski George P
Regulation of C/EBPbeta isoforms by MAPK pathways in HL60 cells induced to differentiate by 1,25-dihydroxyvitamin D3.
Experimental cell research 2006;312(11):2054-65.
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2006: Sharabani Hagar; Izumchenko Eugene; Wang Qing; Kreinin Rita; Steiner Michael; Barvish Zeev; Kafka Michael; Sharoni Yoav; Levy Joseph; Uskokovic Milan; Studzinski George P; Danilenko Michael
Cooperative antitumor effects of vitamin D3 derivatives and rosemary preparations in a mouse model of myeloid leukemia.
International journal of cancer. Journal international du cancer 2006;118(12):3012-21.
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2006: Wang Xuening; Studzinski George P
The requirement for and changing composition of the activating protein-1 transcription factor during differentiation of human leukemia HL60 cells induced by 1,25-dihydroxyvitamin D3.
Cancer research 2006;66(8):4402-9.
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2006: Zhang Yingyu; Zhang Jing; Studzinski George P
AKT pathway is activated by 1, 25-dihydroxyvitamin D3 and participates in its anti-apoptotic effect and cell cycle control in differentiating HL60 cells.
Cell cycle (Georgetown, Tex.) 2006;5(4):447-51.
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2006: Studzinski G P; Garay E; Patel R; Zhang J; Wang X
Vitamin D receptor signaling of monocytic differentiation in human leukemia cells: role of MAPK pathways in transcription factor activation.
Current topics in medicinal chemistry 2006;6(12):1267-71.
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2005: Wang Q; Harrison J S; Uskokovic M; Kutner A; Studzinski G P
Translational study of vitamin D differentiation therapy of myeloid leukemia: effects of the combination with a p38 MAPK inhibitor and an antioxidant.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2005;19(10):1812-7.
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2005: Studzinski George P; Wang Xuening; Ji Yan; Wang Qing; Zhang Yingyu; Kutner Andrzej; Harrison Jonathan S
The rationale for deltanoids in therapy for myeloid leukemia: role of KSR-MAPK-C/EBP pathway.
The Journal of steroid biochemistry and molecular biology 2005;97(1-2):47-55.
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2005: Wang Qing; Salman Hagar; Danilenko Michael; Studzinski George P
Cooperation between antioxidants and 1,25-dihydroxyvitamin D3 in induction of leukemia HL60 cell differentiation through the JNK/AP-1/Egr-1 pathway.
Journal of cellular physiology 2005;204(3):964-74.
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2004: Chen Fei; Wang Qing; Wang Xuening; Studzinski George P
Up-regulation of Egr1 by 1,25-dihydroxyvitamin D3 contributes to increased expression of p35 activator of cyclin-dependent kinase 5 and consequent onset of the terminal phase of HL60 cell differentiation.
Cancer research 2004;64(15):5425-33.
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2004: Danilenko Michael; Studzinski George P
Enhancement by other compounds of the anti-cancer activity of vitamin D(3) and its analogs.
Experimental cell research 2004;298(2):339-58.
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2004: Demidenko Zoya N; Studzinski George P; Blagosklonny Mikhail V
From cytometry to cell cycle: a portrait of Zbigniew Darzynkiewicz.
Cell cycle (Georgetown, Tex.) 2004;3(5):525-8.
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2004: Weyts Franci A; Dhawan Puneet; Zhang Xiaoyu; Bishop June E; Uskokovic Milan R; Ji Yan; Studzinski George P; Norman Anthony W; Christakos Sylvia
Novel Gemini analogs of 1alpha,25-dihydroxyvitamin D(3) with enhanced transcriptional activity.
Biochemical pharmacology 2004;67(7):1327-36.
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2004: Wang Xuening; Studzinski George P
Kinase suppressor of RAS (KSR) amplifies the differentiation signal provided by low concentrations 1,25-dihydroxyvitamin D3.
Journal of cellular physiology 2004;198(3):333-42.
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2004: Ji Yan; Studzinski George P
Retinoblastoma protein and CCAAT/enhancer-binding protein beta are required for 1,25-dihydroxyvitamin D3-induced monocytic differentiation of HL60 cells.
Cancer research 2004;64(1):370-7.
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2003: Wang Qing; Wang Xuening; Studzinski George P
Jun N-terminal kinase pathway enhances signaling of monocytic differentiation of human leukemia cells induced by 1,25-dihydroxyvitamin D3.
Journal of cellular biochemistry 2003;89(6):1087-101.
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2003: Danilenko Michael; Wang Qing; Wang Xuening; Levy Joseph; Sharoni Yoav; Studzinski George P
Carnosic acid potentiates the antioxidant and prodifferentiation effects of 1alpha,25-dihydroxyvitamin D3 in leukemia cells but does not promote elevation of basal levels of intracellular calcium.
Cancer research 2003;63(6):1325-32.
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2003: Studzinski George P; Harrison Jonathan S
The neuronal cyclin-dependent kinase 5 activator p35Nck5a and Cdk5 activity in monocytic cells.
Leukemia & lymphoma 2003;44(2):235-40.
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2002: Ji Yan; Kutner Andrzej; Verstuyf Annemieke; Verlinden Lieve; Studzinski George P
Derivatives of vitamins D2 and D3 activate three MAPK pathways and upregulate pRb expression in differentiating HL60 cells.
Cell cycle (Georgetown, Tex.) 2002;1(6):410-5.
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2002: Ji Yan; Wang Xuening; Donnelly Robert J; Uskokovic Milan R; Studzinski George P
Signaling of monocytic differentiation by a non-hypercalcemic analog of vitamin D3, 1,25(OH)2-5,6 trans-16-ene-vitamin D3, involves nuclear vitamin D receptor (nVDR) and non-nVDR-mediated pathways.
Journal of cellular physiology 2002;191(2):198-207.
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2001: Danilenko M; Wang X; Studzinski G P
Carnosic acid and promotion of monocytic differentiation of HL60-G cells initiated by other agents.
Journal of the National Cancer Institute 2001;93(16):1224-33.
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2001: Wang X; Studzinski G P
Phosphorylation of raf-1 by kinase suppressor of ras is inhibited by "MEK-specific" inhibitors PD 098059 and U0126 in differentiating HL60 cells.
Experimental cell research 2001;268(2):294-300.
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2001: Wang X; Studzinski G P
Inhibition of p38MAP kinase potentiates the JNK/SAPK pathway and AP-1 activity in monocytic but not in macrophage or granulocytic differentiation of HL60 cells.
Journal of cellular biochemistry 2001;82(1):68-77.
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2001: Wang X; Studzinski G P
Activation of extracellular signal-regulated kinases (ERKs) defines the first phase of 1,25-dihydroxyvitamin D3-induced differentiation of HL60 cells.
Journal of cellular biochemistry 2001;80(4):471-82.
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2000: Wang X; Rao J; Studzinski G P
Inhibition of p38 MAP kinase activity up-regulates multiple MAP kinase pathways and potentiates 1,25-dihydroxyvitamin D(3)-induced differentiation of human leukemia HL60 cells.
Experimental cell research 2000;258(2):425-37.
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2000: Wang Q M; Feinman R; Kashanchi F; Houghton J M; Studzinski G P; Harrison L E
Changes in E2F binding after phenylbutyrate-induced differentiation of Caco-2 colon cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(7):2951-8.
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2000: Wang Q M; Studzinski G P; Chen F; Coffman F D; Harrison L E
p53/56(lyn) antisense shifts the 1,25-dihydroxyvitamin D3-induced G1/S block in HL60 cells to S phase.
Journal of cellular physiology 2000;183(2):238-46.
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2000: Chen F; Rao J; Studzinski G P
Specific association of increased cyclin-dependent kinase 5 expression with monocytic lineage of differentiation of human leukemia HL60 cells.
Journal of leukocyte biology 2000;67(4):559-66.
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2000: Chen F; Zhang F; Rao J; Studzinski G P
Ectopic expression of truncated Sp1 transcription factor prolongs the S phase and reduces the growth rate.
Anticancer research 2000;20(2A):661-7.
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1999: Harrison L E; Wang Q M; Studzinski G P
Butyrate-induced G2/M block in Caco-2 colon cancer cells is associated with decreased p34cdc2 activity.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1999;222(2):150-6.
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1999: Harrison L E; Wang Q M; Studzinski G P
1,25-dihydroxyvitamin D(3)-induced retardation of the G(2)/M traverse is associated with decreased levels of p34(cdc2) in HL60 cells.
Journal of cellular biochemistry 1999;75(2):226-34.
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1999: Chen F; Studzinski G P
Cyclin-dependent kinase 5 activity enhances monocytic phenotype and cell cycle traverse in 1,25-dihydroxyvitamin D3-treated HL60 cells.
Experimental cell research 1999;249(2):422-8.
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1999: Coffman F D; Studzinski G P
Differentiation-related mechanisms which suppress DNA replication.
Experimental cell research 1999;248(1):58-73.
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1999: Studzinski G P; Harrison L E
Differentiation-related changes in the cell cycle traverse.
International review of cytology 1999;189():1-58.
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1998: Wang Q M; Chen F; Luo X; Moore D C; Flanagan M; Studzinski G P
Lowering of p27Kip1 levels by its antisense or by development of resistance to 1,25-dihydroxyvitamin D3 reverses the G1 block but not differentiation of HL60 cells.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1998;12(8):1256-65.
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1998: Wang Q M; Luo X; Kheir A; Coffman F D; Studzinski G P
Retinoblastoma protein-overexpressing HL60 cells resistant to 1,25-dihydroxyvitamin D3 display increased CDK2 and CDK6 activity and shortened G1 phase.
Oncogene 1998;16(21):2729-37.
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1998: Rao J; Zhang F; Donnelly R J; Spector N L; Studzinski G P
Truncation of Sp1 transcription factor by myeloblastin in undifferentiated HL60 cells.
Journal of cellular physiology 1998;175(2):121-8.
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1997: Gardner J P; Balasubramanyam M; Studzinski G P
Up-regulation of Ca2+ influx mediated by store-operated channels in HL60 cells induced to differentiate by 1 alpha,25-dihydroxyvitamin D3.
Journal of cellular physiology 1997;172(3):284-95.
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1997: Wang X; Ponzio N M; Studzinski G P
Long-term exposure of HL60 cells to 1,25-dihydroxyvitamin D3 reduces their tumorigenicity: a model for cancer chemoprevention.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1997;215(4):399-404.
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1997: Wang X; Studzinski G P
Antiapoptotic action of 1,25-dihydroxyvitamin D3 is associated with increased mitochondrial MCL-1 and RAF-1 proteins and reduced release of cytochrome c.
Experimental cell research 1997;235(1):210-7.
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1997: Wang X; Gardner J P; Kheir A; Uskokovic M R; Studzinski G P
Synergistic induction of HL60 cell differentiation by ketoconazole and 1-desoxy analogues of vitamin D3.
Journal of the National Cancer Institute 1997;89(16):1199-206.
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1997: Wang Q M; Luo X; Studzinski G P
Cyclin-dependent kinase 6 is the principal target of p27/Kip1 regulation of the G1-phase traverse in 1,25-dihydroxyvitamin D3-treated HL60 cells.
Cancer research 1997;57(14):2851-5.
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1997: Studzinski G P; Rathod B; Wang Q M; Rao J; Zhang F
Uncoupling of cell cycle arrest from the expression of monocytic differentiation markers in HL60 cell variants.
Experimental cell research 1997;232(2):376-87.
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1996: Gardner J P; Zhang F; Uskokovic M R; Studzinski G P
Vitamin D analog 25-(OH)-16,23E-Diene-26,27-hexafluoro-vitamin D3 induces differentiation of HL60 cells with minimal effects on cellular calcium homeostasis.
Journal of cellular biochemistry 1996;63(4):500-12.
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1996: Studzinski G P; Rathod B; Rao J; Kheir A; Wajchman H J; Zhang F; Finan J B; Nowell P C
Transition to tetraploidy in 1,25-dihydroxyvitamin D3-resistant HL60 cells is preceded by reduced growth factor dependence and constitutive up-regulation of Sp1 and AP-1 transcription factors.
Cancer research 1996;56(23):5513-21.
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1996: Zhang F; Rathod B; Jones J B; Wang Q M; Bernhard E; Godyn J J; Studzinski G P
Increased stringency of the 1,25-dihydroxyvitamin D3-induced G1 to S phase block in polyploid HL60 cells.
Journal of cellular physiology 1996;168(1):18-25.
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1996: Wajchmann H J; Rathod B; Song S; Xu H; Wang X; Uskokovic M R; Studzinski G P
Loss of deoxcytidine kinase expression and tetraploidization of HL60 cells following long-term culture in 1,25-dihydroxyvitamin D3.
Experimental cell research 1996;224(2):312-22.
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1996: Wang Q M; Jones J B; Studzinski G P
Cyclin-dependent kinase inhibitor p27 as a mediator of the G1-S phase block induced by 1,25-dihydroxyvitamin D3 in HL60 cells.
Cancer research 1996;56(2):264-7.
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1995: Studzinski G P; Moore D C
Sunlight--can it prevent as well as cause cancer?
Cancer research 1995;55(18):4014-22.
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1994: Kolla S S; Studzinski G P
Constitutive DNA binding of the low mobility forms of the AP-1 and SP-1 transcription factors in HL60 cells resistant to 1-beta-D-arabinofuranosylcytosine.
Cancer research 1994;54(6):1418-21.
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1994: Godyn J J; Xu H; Zhang F; Kolla S; Studzinski G P
A dual block to cell cycle progression in HL60 cells exposed to analogues of vitamin D3.
Cell proliferation 1994;27(1):37-46.
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1993: Xu H M; Tepper C G; Jones J B; Fernandez C E; Studzinski G P
1,25-Dihydroxyvitamin D3 protects HL60 cells against apoptosis but down-regulates the expression of the bcl-2 gene.
Experimental cell research 1993;209(2):367-74.
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1993: Kolla S S; Studzinski G P
Resolution of multiple AP-1 complexes in HL-60 cells induced to differentiate by 1,25-dihydroxyvitamin D3.
Journal of cellular physiology 1993;156(1):63-71.
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1993: Tepper C G; Studzinski G P
Resistance of mitochondrial DNA to degradation characterizes the apoptotic but not the necrotic mode of human leukemia cell death.
Journal of cellular biochemistry 1993;52(3):352-61.
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1993: Studzinski G P; McLane J A; Uskokovic M R
Signaling pathways for vitamin D-induced differentiation: implications for therapy of proliferative and neoplastic diseases.
Critical reviews in eukaryotic gene expression 1993;3(4):279-312.
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1992: Xu H M; Kolla S S; Goldenberg N A; Studzinski G P
Resistance to 1,25-dihydroxyvitamin D3 of a deoxycytidine kinase-deficient variant of human leukemia HL60 cells.
Experimental cell research 1992;203(1):244-50.
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1992: Tepper C G; Studzinski G P
Teniposide induces nuclear but not mitochondrial DNA degradation.
Cancer research 1992;52(12):3384-90.
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1992: Moore D C; Carter D L; Studzinski G P
Inhibition by 1,25 dihydroxyvitamin D3 of c-myc down-regulation and DNA fragmentation in cytosine arabinoside-induced erythroid differentiation of K562 cells.
Journal of cellular physiology 1992;151(3):539-48.
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1992: Tepper C G; Pater M M; Pater A; Xu H M; Studzinski G P
Mitochondrial nucleic acids as internal standards for blot hybridization analyses.
Analytical biochemistry 1992;203(1):127-33.
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1991: Studzinski G P; Reddy K B; Hill H Z; Bhandal A K
Potentiation of 1-beta-D-arabinofuranosylcytosine cytotoxicity to HL-60 cells by 1,25-dihydroxyvitamin D3 correlates with reduced rate of maturation of DNA replication intermediates.
Cancer research 1991;51(13):3451-5.
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1991: Kolla S S; Moore D C; Studzinski G P
Vitamin D analogs inhibit erythroid differentiation and induce monocytic differentiation of leukemic cells with the same relative potency.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1991;197(2):214-7.
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1991: Studzinski G P; Shankavaram U T; Moore D C; Reddy P V
Association of c-myc protein with enzymes of DNA replication in high molecular weight fractions from mammalian cells.
Journal of cellular physiology 1991;147(3):412-9.
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1991: Moore D C; Carter D L; Bhandal A K; Studzinski G P
Inhibition by 1,25 dihydroxyvitamin D3 of chemically induced erythroid differentiation of K562 leukemia cells.
Blood 1991;77(7):1452-61.
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1991: Pan P; Reddy K; Lee S; Studzinski G P
Differentiation-related regulation of 1,25-dihydroxyvitamin D3 receptor mRNA in human leukaemia cells HL-60.
Cell proliferation 1991;24(2):159-70.
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1990: Satav J G; Modak M J; Studzinski G P
Photoaffinity labeling of human c-myc protein with deoxythymidine triphosphate.
Laboratory investigation; a journal of technical methods and pathology 1990;63(4):551-6.
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1989: Studzinski G P
Oncogenes, growth, and the cell cycle: an overview.
Cell and tissue kinetics 1989;22(6):405-24.
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1989: Mathew P A; Ellis L K; Studzinski G P
Enhanced messenger RNA stability and differentiation of HL 60 cells treated with 1,25-dihydroxyvitamin D3 and cordycepin.
Journal of cellular physiology 1989;140(2):212-8.
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1987: Studzinski G P; Brelvi Z S
Changes in proto-oncogene expression associated with reversal of macrophage-like differentiation of HL 60 cells.
Journal of the National Cancer Institute 1987;79(1):67-76.
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1987: Studzinski G P; Brelvi Z S
Increased expression of oncogene c-Ha-ras during granulocytic differentiation of HL60 cells.
Laboratory investigation; a journal of technical methods and pathology 1987;56(5):499-504.
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1987: Brelvi Z S; Studzinski G P
Coordinate expression of c-myc, c-myb, and histone H4 genes in reversibly differentiating HL 60 cells.
Journal of cellular physiology 1987;131(1):43-9.
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1986: Studzinski G P; Brelvi Z S; Feldman S C; Watt R A
Participation of c-myc protein in DNA synthesis of human cells.
Science (New York, N.Y.) 1986;234(4775):467-70.
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1986: Brelvi Z S; Christakos S; Studzinski G P
Expression of monocyte-specific oncogenes c-fos and c-fms in HL60 cells treated with vitamin D3 analogs correlates with inhibition of DNA synthesis and reduced calmodulin concentration.
Laboratory investigation; a journal of technical methods and pathology 1986;55(3):269-75.
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1986: Brelvi Z S; Studzinski G P
Inhibition of DNA synthesis by an inducer of differentiation of leukemic cells, 1 alpha, 25 dihydroxy vitamin D3, precedes down regulation of the c-myc gene.
Journal of cellular physiology 1986;128(2):171-9.
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1986: Brelvi Z S; Studzinski G P
Changes in the expression of oncogenes encoding nuclear phosphoproteins but not c-Ha-ras have a relationship to monocytic differentiation of HL 60 cells.
The Journal of cell biology 1986;102(6):2234-43.
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1986: Studzinski G P; Bhandal A K; Brelvi Z S
Potentiation by 1-alpha,25-dihydroxyvitamin D3 of cytotoxicity to HL-60 cells produced by cytarabine and hydroxyurea.
Journal of the National Cancer Institute 1986;76(4):641-8.
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1985: Studzinski G P; Bhandal A K; Brelvi Z S
Cell cycle sensitivity of HL-60 cells to the differentiation-inducing effects of 1-alpha,25-dihydroxyvitamin D3.
Cancer research 1985;45(8):3898-905.
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1985: Studzinski G P; Bhandal A K; Brelvi Z S
A system for monocytic differentiation of leukemic cells HL 60 by a short exposure to 1,25-dihydroxycholecalciferol.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1985;179(3):288-95.
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