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Dennis Stuehr

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
24
aulak, kulwant
22
Abu-Soud, Husam
19
Getzoff, Elizabeth
16
Adak, Subrata
16
Wang, Zhi-Qiang
16
Wei, Chin-Chuan
15
Boucher, Jean-Luc
15
Mansuy, Daniel
15
Panda, Koustubh
14
Crane, Brian
13
Koeck, Thomas
12
Rousseau, Denis
12
Ghosh, DK
12
Tainer, John
10
Ghosh, Sanjay

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Publications

TOP 3
Sabat Joseph; Stuehr Dennis J; Yeh Syun-Ru; Rousseau Denis L
Characterization of the proximal ligand in the P420 form of inducible nitric oxide synthase.
Tejero Jesús; Santolini Jérôme; Stuehr Dennis J
Fast ferrous heme-NO oxidation in nitric oxide synthases.
Stuehr Dennis J; Tejero Jesús; Haque Mohammad M
Structural and mechanistic aspects of flavoproteins: electron transfer through the nitric oxide synthase flavoprotein domain.

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All Publications

2009: Sabat Joseph; Stuehr Dennis J; Yeh Syun-Ru; Rousseau Denis L
Characterization of the proximal ligand in the P420 form of inducible nitric oxide synthase.
Journal of the American Chemical Society 2009;131(34):12186-92.
2009: Tejero Jesús; Santolini Jérôme; Stuehr Dennis J
Fast ferrous heme-NO oxidation in nitric oxide synthases.
The FEBS journal 2009;276(16):4505-14.
2009: Stuehr Dennis J; Tejero Jesús; Haque Mohammad M
Structural and mechanistic aspects of flavoproteins: electron transfer through the nitric oxide synthase flavoprotein domain.
The FEBS journal 2009;276(15):3959-74.
2009: Haque Mohammad Mahfuzul; Fadlalla Mohammed; Wang Zhi-Qiang; Ray Sougata Sinha; Panda Koustubh; Stuehr Dennis J
Neutralizing a surface charge on the FMN subdomain increases the activity of neuronal nitric-oxide synthase by enhancing the oxygen reactivity of the enzyme heme-nitric oxide complex.
The Journal of biological chemistry 2009;284(29):19237-47.
2009: Ilagan Robielyn P; Tejero Jesús; Aulak Kulwant S; Ray Sougata Sinha; Hemann Craig; Wang Zhi-Qiang; Gangoda Mahinda; Zweier Jay L; Stuehr Dennis J
Regulation of FMN subdomain interactions and function in neuronal nitric oxide synthase.
Biochemistry 2009;48(18):3864-76.
2009: Koeck Thomas; Corbett John A; Crabb John W; Stuehr Dennis J; Aulak Kulwant S
Glucose-modulated tyrosine nitration in beta cells: targets and consequences.
Archives of biochemistry and biophysics 2009;484(2):221-31.
2009: Fan Baochen; Stuehr Dennis J; Rousseau Denis L
Role of substrate functional groups in binding to nitric oxide synthase.
Biochemical and biophysical research communications 2009;382(1):21-5.
2009: Koeck Thomas; Willard Belinda; Crabb John W; Kinter Mike; Stuehr Dennis J; Aulak Kulwant S
Glucose-mediated tyrosine nitration in adipocytes: targets and consequences.
Free radical biology & medicine 2009;46(7):884-92.
2009: Wegrzyn Joanna; Potla Ramesh; Chwae Yong-Joon; Sepuri Naresh B V; Zhang Qifang; Koeck Thomas; Derecka Marta; Szczepanek Karol; Szelag Magdalena; Gornicka Agnieszka; Moh Akira; Moghaddas Shadi; Chen Qun; Bobbili Santha; Cichy Joanna; Dulak Jozef; Baker Darren P; Wolfman Alan; Stuehr Dennis; Hassan Medhat O; Fu Xin-Yuan; Avadhani Narayan; Drake Jennifer I; Fawcett Paul; Lesnefsky Edward J; Larner Andrew C
Function of mitochondrial Stat3 in cellular respiration.
Science (New York, N.Y.) 2009;323(5915):793-7.
2008: Garcin Elsa D; Arvai Andrew S; Rosenfeld Robin J; Kroeger Matt D; Crane Brian R; Andersson Gunilla; Andrews Glen; Hamley Peter J; Mallinder Philip R; Nicholls David J; St-Gallay Stephen A; Tinker Alan C; Gensmantel Nigel P; Mete Antonio; Cheshire David R; Connolly Stephen; Stuehr Dennis J; Aberg Anders; Wallace Alan V; Tainer John A; Getzoff Elizabeth D
Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase.
Nature chemical biology 2008;4(11):700-7.
2008: Tejero Jesús; Biswas Ashis; Wang Zhi-Qiang; Page Richard C; Haque Mohammad Mahfuzul; Hemann Craig; Zweier Jay L; Misra Saurav; Stuehr Dennis J
Stabilization and characterization of a heme-oxy reaction intermediate in inducible nitric-oxide synthase.
The Journal of biological chemistry 2008;283(48):33498-507.
2008: Donzelli Sonia; Espey Michael Graham; Flores-Santana Wilmarie; Switzer Christopher H; Yeh Grace C; Huang Jinming; Stuehr Dennis J; King S Bruce; Miranda Katrina M; Wink David A
Generation of nitroxyl by heme protein-mediated peroxidation of hydroxylamine but not N-hydroxy-L-arginine.
Free radical biology & medicine 2008;45(5):578-84.
2008: Ilagan Robielyn P; Tiso Mauro; Konas David W; Hemann Craig; Durra Deborah; Hille Russ; Stuehr Dennis J
Differences in a conformational equilibrium distinguish catalysis by the endothelial and neuronal nitric-oxide synthase flavoproteins.
The Journal of biological chemistry 2008;283(28):19603-15.
2008: Cottyn Betty; Acher Francine; Ramassamy Booma; Alvey Luke; Lepoivre Michel; Frapart Yves; Stuehr Dennis; Mansuy Daniel; Boucher Jean-Luc; Vichard Dominique
Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: particular potency of 1H-indazole-7-carbonitrile.
Bioorganic & medicinal chemistry 2008;16(11):5962-73.
2008: Gusarov Ivan; Starodubtseva Marina; Wang Zhi-Qiang; McQuade Lindsey; Lippard Stephen J; Stuehr Dennis J; Nudler Evgeny
Bacterial nitric-oxide synthases operate without a dedicated redox partner.
The Journal of biological chemistry 2008;283(19):13140-7.
2008: Chandor Alexia; Dijols Sylvie; Ramassamy Booma; Frapart Yves; Mansuy Daniel; Stuehr Dennis; Helsby Nuala; Boucher Jean-Luc
Metabolic activation of the antitumor drug 5-(Aziridin-1-yl)-2,4-dinitrobenzamide (CB1954) by NO synthases.
Chemical research in toxicology 2008;21(4):836-43.
2008: Wei Chin-Chuan; Wang Zhi-Qiang; Tejero Jesús; Yang Ya-Ping; Hemann Craig; Hille Russ; Stuehr Dennis J
Catalytic reduction of a tetrahydrobiopterin radical within nitric-oxide synthase.
The Journal of biological chemistry 2008;283(17):11734-42.
2008: Tiso Mauro; Strub Andreas; Hesslinger Christian; Kenney Claire T; Boer Rainer; Stuehr Dennis J
BYK191023 (2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3h-imidazo[4,5-b]pyridine) is an NADPH- and time-dependent irreversible inhibitor of inducible nitric-oxide synthase.
Molecular pharmacology 2008;73(4):1244-53.
2007: Tiso Mauro; Tejero Jesús; Panda Koustubh; Aulak Kulwant S; Stuehr Dennis J
Versatile regulation of neuronal nitric oxide synthase by specific regions of its C-terminal tail.
Biochemistry 2007;46(50):14418-28.
2007: Beaumont Edward; Lambry Jean-Christophe; Wang Zhi-Qiang; Stuehr Dennis J; Martin Jean-Louis; Slama-Schwok Anny
Distal Val346Ile mutation in inducible NO synthase promotes substrate-dependent NO confinement.
Biochemistry 2007;46(47):13533-40.
2007: Erzurum S C; Ghosh S; Janocha A J; Xu W; Bauer S; Bryan N S; Tejero J; Hemann C; Hille R; Stuehr D J; Feelisch M; Beall C M
Higher blood flow and circulating NO products offset high-altitude hypoxia among Tibetans.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(45):17593-8.
2007: Ray Sougata Sinha; Sengupta Rajib; Tiso Mauro; Haque Mohammad Mahfuzul; Sahoo Rupam; Konas David W; Aulak Kulwant; Regulski Michael; Tully Tim; Stuehr Dennis J; Ghosh Sanjay
Reductase domain of Drosophila melanogaster nitric-oxide synthase: redox transformations, regulation, and similarity to mammalian homologues.
Biochemistry 2007;46(42):11865-73.
2007: Ray Sougata Sinha; Tejero Jesús; Wang Zhi-Qiang; Dutta Tanmay; Bhattacharjee Arindam; Regulski Michael; Tully Tim; Ghosh Sanjay; Stuehr Dennis J
Oxygenase domain of Drosophila melanogaster nitric oxide synthase: unique kinetic parameters enable a more efficient NO release.
Biochemistry 2007;46(42):11857-64.
2007: Haque Mohammad Mahfuzul; Panda Koustubh; Tejero Jesús; Aulak Kulwant S; Fadlalla Mohammed Adam; Mustovich Anthony T; Stuehr Dennis J
A connecting hinge represses the activity of endothelial nitric oxide synthase.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(22):9254-9.
2007: Li David; Kabir Mariam; Stuehr Dennis J; Rousseau Denis L; Yeh Syun-Ru
Substrate- and isoform-specific dioxygen complexes of nitric oxide synthase.
Journal of the American Chemical Society 2007;129(21):6943-51.
2007: Maréchal Amandine; Mattioli Tony A; Stuehr Dennis J; Santolini Jérôme
Activation of peroxynitrite by inducible nitric-oxide synthase: a direct source of nitrative stress.
The Journal of biological chemistry 2007;282(19):14101-12.
2007: Jagnandan Davin; Church Jarrod E; Banfi Botond; Stuehr Dennis J; Marrero Mario B; Fulton David J R
Novel mechanism of activation of NADPH oxidase 5. calcium sensitization via phosphorylation.
The Journal of biological chemistry 2007;282(9):6494-507.
2007: Xu Weiling; Koeck Thomas; Lara Abigail R; Neumann Donald; DiFilippo Frank P; Koo Michelle; Janocha Allison J; Masri Fares A; Arroliga Alejandro C; Jennings Constance; Dweik Raed A; Tuder Rubin M; Stuehr Dennis J; Erzurum Serpil C
Alterations of cellular bioenergetics in pulmonary artery endothelial cells.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(4):1342-7.
2007: Wang Zhi-Qiang; Lawson Rachel J; Buddha Madhavan R; Wei Chin-Chuan; Crane Brian R; Munro Andrew W; Stuehr Dennis J
Bacterial flavodoxins support nitric oxide production by Bacillus subtilis nitric-oxide synthase.
The Journal of biological chemistry 2007;282(4):2196-202.
2006: Panda Koustubh; Haque Mohammad Mahfuzul; Garcin-Hosfield Elsa D; Durra Deborah; Getzoff Elizabeth D; Stuehr Dennis J
Surface charge interactions of the FMN module govern catalysis by nitric-oxide synthase.
The Journal of biological chemistry 2006;281(48):36819-27.
2006: Potla Ramesh; Koeck Thomas; Wegrzyn Joanna; Cherukuri Srujana; Shimoda Kazuya; Baker Darren P; Wolfman Janice; Planchon Sarah M; Esposito Christine; Hoit Brian; Dulak Jozef; Wolfman Alan; Stuehr Dennis; Larner Andrew C
Tyk2 tyrosine kinase expression is required for the maintenance of mitochondrial respiration in primary pro-B lymphocytes.
Molecular and cellular biology 2006;26(22):8562-71.
2006: Konas David W; Takaya Naoki; Sharma Manisha; Stuehr Dennis J
Role of Asp1393 in catalysis, flavin reduction, NADP(H) binding, FAD thermodynamics, and regulation of the nNOS flavoprotein.
Biochemistry 2006;45(41):12596-609.
2006: Moreau Magali; Boucher Jean-Luc; Mattioli Tony A; Stuehr Dennis J; Mansuy Daniel; Santolini Jérôme
Differential effects of alkyl- and arylguanidines on the stability and reactivity of inducible NOS heme-dioxygen complexes.
Biochemistry 2006;45(12):3988-99.
2006: Li David; Hayden Eric Y; Panda Koustubh; Stuehr Dennis J; Deng Haiteng; Rousseau Denis L; Yeh Syun-Ru
Regulation of the monomer-dimer equilibrium in inducible nitric-oxide synthase by nitric oxide.
The Journal of biological chemistry 2006;281(12):8197-204.
2006: Santolini Jérôme; Roman Miruna; Stuehr Dennis J; Mattioli Tony A
Resonance Raman study of Bacillus subtilis NO synthase-like protein: similarities and differences with mammalian NO synthases.
Biochemistry 2006;45(5):1480-9.
2006: Lefèvre-Groboillot David; Boucher Jean-Luc; Mansuy Daniel; Stuehr Dennis J
Reactivity of the heme-dioxygen complex of the inducible nitric oxide synthase in the presence of alternative substrates.
The FEBS journal 2006;273(1):180-91.
2005: Koeck T; Stuehr D J; Aulak K S
Mitochondria and regulated tyrosine nitration.
Biochemical Society transactions 2005;33(Pt 6):1399-403.
2005: Belliston-Bittner Wendy; Dunn Alexander R; Nguyen Yen Hoang Le; Stuehr Dennis J; Winkler Jay R; Gray Harry B
Picosecond photoreduction of inducible nitric oxide synthase by rhenium(I)-diimine wires.
Journal of the American Chemical Society 2005;127(45):15907-15.
2005: Stuehr Dennis J; Wei Chin-Chuan; Wang Zhiqiang; Hille Russ
Exploring the redox reactions between heme and tetrahydrobiopterin in the nitric oxide synthases.
Dalton transactions (Cambridge, England : 2003) 2005;(21):3427-35.
2005: Tiso Mauro; Konas David W; Panda Koustubh; Garcin Elsa D; Sharma Manisha; Getzoff Elizabeth D; Stuehr Dennis J
C-terminal tail residue Arg1400 enables NADPH to regulate electron transfer in neuronal nitric-oxide synthase.
The Journal of biological chemistry 2005;280(47):39208-19.
2005: Masri Fares A; Comhair Suzy A A; Koeck Thomas; Xu Weiling; Janocha Allison; Ghosh Sudakshina; Dweik Raed A; Golish Joseph; Kinter Michael; Stuehr Dennis J; Erzurum Serpil C; Aulak Kulwant S
Abnormalities in nitric oxide and its derivatives in lung cancer.
American journal of respiratory and critical care medicine 2005;172(5):597-605.
2005: Panda Koustubh; Chawla-Sarkar Mamta; Santos Cecile; Koeck Thomas; Erzurum Serpil C; Parkinson John F; Stuehr Dennis J
Visualizing inducible nitric-oxide synthase in living cells with a heme-binding fluorescent inhibitor.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(29):10117-22.
2005: Lefèvre-Groboillot David; Boucher Jean-Luc; Stuehr Dennis J; Mansuy Daniel
Relationship between the structure of guanidines and N-hydroxyguanidines, their binding to inducible nitric oxide synthase (iNOS) and their iNOS-catalysed oxidation to NO.
The FEBS journal 2005;272(12):3172-83.
2005: Dunn Alexander R; Belliston-Bittner Wendy; Winkler Jay R; Getzoff Elizabeth D; Stuehr Dennis J; Gray Harry B
Luminescent ruthenium(II)- and rhenium(I)-diimine wires bind nitric oxide synthase.
Journal of the American Chemical Society 2005;127(14):5169-73.
2005: Jeng Bennie H; Shadrach Karen G; Meisler David M; Hollyfield Joe G; Connor Jason T; Koeck Thomas; Aulak Kulwant S; Stuehr Dennis J
Immunohistochemical detection and Western blot analysis of nitrated protein in stored human corneal epithelium.
Experimental eye research 2005;80(4):509-14.
2005: Wang Zhi-Qiang; Wei Chin-Chuan; Santolini Jerome; Panda Koustubh; Wang Qian; Stuehr Dennis J
A tryptophan that modulates tetrahydrobiopterin-dependent electron transfer in nitric oxide synthase regulates enzyme catalysis by additional mechanisms.
Biochemistry 2005;44(12):4676-90.
2005: Wei Chin-Chuan; Wang Zhi-Qiang; Durra Deborah; Hemann Craig; Hille Russ; Garcin Elsa D; Getzoff Elizabeth D; Stuehr Dennis J
The three nitric-oxide synthases differ in their kinetics of tetrahydrobiopterin radical formation, heme-dioxy reduction, and arginine hydroxylation.
The Journal of biological chemistry 2005;280(10):8929-35.
2004: Stuehr Dennis J
Enzymes of the L-arginine to nitric oxide pathway.
The Journal of nutrition 2004;134(10 Suppl):2748S-2751S; discussion 2765S-2767S.
2004: Garcin Elsa D; Bruns Christopher M; Lloyd Sarah J; Hosfield David J; Tiso Mauro; Gachhui Ratan; Stuehr Dennis J; Tainer John A; Getzoff Elizabeth D
Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase.
The Journal of biological chemistry 2004;279(36):37918-27.
2004: Konas David W; Zhu Keng; Sharma Manisha; Aulak Kulwant S; Brudvig Gary W; Stuehr Dennis J
The FAD-shielding residue Phe1395 regulates neuronal nitric-oxide synthase catalysis by controlling NADP+ affinity and a conformational equilibrium within the flavoprotein domain.
The Journal of biological chemistry 2004;279(34):35412-25.
2004: Stuehr Dennis J; Santolini Jerome; Wang Zhi-Qiang; Wei Chin-Chuan; Adak Subrata
Update on mechanism and catalytic regulation in the NO synthases.
The Journal of biological chemistry 2004;279(35):36167-70.
2004: Koeck Thomas; Fu Xiaoming; Hazen Stanley L; Crabb John W; Stuehr Dennis J; Aulak Kulwant S
Rapid and selective oxygen-regulated protein tyrosine denitration and nitration in mitochondria.
The Journal of biological chemistry 2004;279(26):27257-62.
2004: Li David; Stuehr Dennis J; Yeh Syun-Ru; Rousseau Denis L
Heme distortion modulated by ligand-protein interactions in inducible nitric-oxide synthase.
The Journal of biological chemistry 2004;279(25):26489-99.
2004: Koeck Thomas; Levison Bruce; Hazen Stanley L; Crabb John W; Stuehr Dennis J; Aulak Kulwant S
Tyrosine nitration impairs mammalian aldolase A activity.
Molecular & cellular proteomics : MCP 2004;3(6):548-57.
2004: Meisler David M; Koeck Thomas; Connor Jason T; Aulak Kulwant S; Jeng Bennie H; Hollyfield Joe G; Stuehr Dennis J; Shadrach Karen G
Inhibition of nitric oxide synthesis in corneas in storage media.
Experimental eye research 2004;78(4):891-4.
2004: Wang Zhi-Qiang; Wei Chin-Chuan; Sharma Manisha; Pant Kartikeya; Crane Brian R; Stuehr Dennis J
A conserved Val to Ile switch near the heme pocket of animal and bacterial nitric-oxide synthases helps determine their distinct catalytic profiles.
The Journal of biological chemistry 2004;279(18):19018-25.
2004: Panda Koustubh; Adak Subrata; Konas David; Sharma Manisha; Stuehr Dennis J
A conserved aspartate (Asp-1393) regulates NADPH reduction of neuronal nitric-oxide synthase: implications for catalysis.
The Journal of biological chemistry 2004;279(18):18323-33.
2004: Gautier Clement; Négrerie Michel; Wang Zhi-Qiang; Lambry Jean-Christophe; Stuehr Dennis J; Collin Fabrice; Martin Jean-Louis; Slama-Schwok Anny
Dynamic regulation of the inducible nitric-oxide synthase by NO: comparison with the endothelial isoform.
The Journal of biological chemistry 2004;279(6):4358-65.
2004: Aulak Kulwant S; Koeck Thomas; Crabb John W; Stuehr Dennis J
Dynamics of protein nitration in cells and mitochondria.
American journal of physiology. Heart and circulatory physiology 2004;286(1):H30-8.
2004: Stuehr Dennis J; Wei Chin-Chuan; Santolini Jerome; Wang Zhi- Qiang; Aoyagi Mika; Getzoff Elizabeth D
Radical reactions of nitric oxide synthases.
Biochemical Society symposium 2004;(71):39-49.
2004: Aulak Kulwant S; Koeck Thomas; Crabb John W; Stuehr Dennis J
Proteomic method for identification of tyrosine-nitrated proteins.
Methods in molecular biology (Clifton, N.J.) 2004;279():151-65.
2003: Ask K; Dijols S; Giroud C; Casse L; Frapart Y-M; Sari M-A; Kim K-S; Stuehr D J; Mansuy D; Camus P; Boucher J-L
Reduction of nilutamide by NO synthases: implications for the adverse effects of this nitroaromatic antiandrogen drug.
Chemical research in toxicology 2003;16(12):1547-54.
2003: Sawa Tomohiro; Akaike Takaaki; Ichimori Koji; Akuta Teruo; Kaneko Kazuyoshi; Nakayama Hitoshi; Stuehr Dennis J; Maeda Hiroshi
Superoxide generation mediated by 8-nitroguanosine, a highly redox-active nucleic acid derivative.
Biochemical and biophysical research communications 2003;311(2):300-6.
2003: Wei Chin-Chuan; Wang Zhi-Qiang; Hemann Craig; Hille Russ; Stuehr Dennis J
A tetrahydrobiopterin radical forms and then becomes reduced during Nomega-hydroxyarginine oxidation by nitric-oxide synthase.
The Journal of biological chemistry 2003;278(47):46668-73.
2003: Panda Koustubh; Adak Subrata; Aulak Kulwant S; Santolini Jerome; McDonald John F; Stuehr Dennis J
Distinct influence of N-terminal elements on neuronal nitric-oxide synthase structure and catalysis.
The Journal of biological chemistry 2003;278(39):37122-31.
2003: Turko Illarion V; Li Li; Aulak Kulwant S; Stuehr Dennis J; Chang Jui-Yoa; Murad Ferid
Protein tyrosine nitration in the mitochondria from diabetic mouse heart. Implications to dysfunctional mitochondria in diabetes.
The Journal of biological chemistry 2003;278(36):33972-7.
2003: Sengupta Rajib; Sahoo Rupam; Mukherjee Shaeri; Regulski Michael; Tully Tim; Stuehr Dennis J; Ghosh Sanjay
Characterization of Drosophila nitric oxide synthase: a biochemical study.
Biochemical and biophysical research communications 2003;306(2):590-7.
2003: Wei Chin-Chuan; Crane Brian R; Stuehr Dennis J
Tetrahydrobiopterin radical enzymology.
Chemical reviews 2003;103(6):2365-83.
2003: Lefèvre-Groboillot David; Frapart Yves; Desbois Alain; Zimmermann Jean-Luc; Boucher Jean-Luc; Gorren Antonius C F; Mayer Bernd; Stuehr Dennis J; Mansuy Daniel
Two modes of binding of N-hydroxyguanidines to NO synthases: first evidence for the formation of iron-N-hydroxyguanidine complexes and key role of tetrahydrobiopterin in determining the binding mode.
Biochemistry 2003;42(13):3858-67.
2003: Voegtle Heather L; Sono Masanori; Adak Subrata; Pond Alycen E; Tomita Takeshi; Perera Roshan; Goodin David B; Ikeda-Saito Masao; Stuehr Dennis J; Dawson John H
Spectroscopic characterization of five- and six-coordinate ferrous-NO heme complexes. Evidence for heme Fe-proximal cysteinate bond cleavage in the ferrous-NO adducts of the Trp-409Tyr/Phe proximal environment mutants of neuronal nitric oxide synthase.
Biochemistry 2003;42(8):2475-84.
2003: Wei Chin-Chuan; Wang Zhi-Qiang; Arvai Andrew S; Hemann Craig; Hille Russ; Getzoff Elizabeth D; Stuehr Dennis J
Structure of tetrahydrobiopterin tunes its electron transfer to the heme-dioxy intermediate in nitric oxide synthase.
Biochemistry 2003;42(7):1969-77.
2002: Rosenfeld Robin J; Garcin Elsa D; Panda Koustubh; Andersson Gunilla; Aberg Anders; Wallace Alan V; Morris Garrett M; Olson Arthur J; Stuehr Dennis J; Tainer John A; Getzoff Elizabeth D
Conformational changes in nitric oxide synthases induced by chlorzoxazone and nitroindazoles: crystallographic and computational analyses of inhibitor potency.
Biochemistry 2002;41(47):13915-25.
2002: Zamora Ruben; Vodovotz Yoram; Aulak Kulwant S; Kim Peter K M; Kane John M; Alarcon Louis; Stuehr Dennis J; Billiar Timothy R
A DNA microarray study of nitric oxide-induced genes in mouse hepatocytes: implications for hepatic heme oxygenase-1 expression in ischemia/reperfusion.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2002;7(3):165-86.
2002: Adak Subrata; Sharma Manisha; Meade Abigail L; Stuehr Dennis J
A conserved flavin-shielding residue regulates NO synthase electron transfer and nicotinamide coenzyme specificity.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(21):13516-21.
2002: Wei Chin-Chuan; Wang Zhi-Qiang; Meade Abigail L; McDonald John F; Stuehr Dennis J
Why do nitric oxide synthases use tetrahydrobiopterin?
Journal of inorganic biochemistry 2002;91(4):618-24.
2002: Pant Kartikeya; Bilwes Alexandrine M; Adak Subrata; Stuehr Dennis J; Crane Brian R
Structure of a nitric oxide synthase heme protein from Bacillus subtilis.
Biochemistry 2002;41(37):11071-9.
2002: Panda Koustubh; Rosenfeld Robin J; Ghosh Sanjay; Meade Abigail L; Getzoff Elizabeth D; Stuehr Dennis J
Distinct dimer interaction and regulation in nitric-oxide synthase types I, II, and III.
The Journal of biological chemistry 2002;277(34):31020-30.
2002: Dijols Sylvie; Boucher Jean-Luc; Lepoivre Michel; Lefevre-Groboillot David; Moreau Magali; Frapart Yves; Rekka Eleni; Meade Abigail L; Stuehr Dennis J; Mansuy Daniel
First non-alpha-amino acid guanidines acting as efficient NO precursors upon oxidation by NO-synthase II or activated mouse macrophages.
Biochemistry 2002;41(30):9286-92.
2002: Jeng Bennie H; Meisler David M; Hollyfield Joe G; Connor Jason T; Aulak Kulwant S; Stuehr Dennis J
Nitric oxide generated by corneas in corneal storage media.
Cornea 2002;21(4):410-4.
2002: Adak Subrata; Aulak Kulwant S; Stuehr Dennis J
Direct evidence for nitric oxide production by a nitric-oxide synthase-like protein from Bacillus subtilis.
The Journal of biological chemistry 2002;277(18):16167-71.
2002: Miyagi Masaru; Sakaguchi Hirokazu; Darrow Ruth M; Yan Lin; West Karen A; Aulak Kulwant S; Stuehr Dennis J; Hollyfield Joe G; Organisciak Daniel T; Crabb John W
Evidence that light modulates protein nitration in rat retina.
Molecular & cellular proteomics : MCP 2002;1(4):293-303.
2002: Chen Yishi; Panda Koustubh; Stuehr Dennis J
Control of nitric oxide synthase dimer assembly by a heme-NO-dependent mechanism.
Biochemistry 2002;41(14):4618-25.
2002: Wang Zhi-Qiang; Wei Chin-Chuan; Stuehr Dennis J
A conserved tryptophan 457 modulates the kinetics and extent of N-hydroxy-L-arginine oxidation by inducible nitric-oxide synthase.
The Journal of biological chemistry 2002;277(15):12830-7.
2002: Renodon-Cornière Axelle; Dijols Sylvie; Perollier Céline; Lefevre-Groboillot David; Boucher Jean-Luc; Attias Roger; Sari Marie-Agnes; Stuehr Dennis; Mansuy Daniel
N-Aryl N'-hydroxyguanidines, a new class of NO-donors after selective oxidation by nitric oxide synthases: structure-activity relationship.
Journal of medicinal chemistry 2002;45(4):944-54.
2002: Adak Subrata; Bilwes Alexandrine M; Panda Koustubh; Hosfield David; Aulak Kulwant S; McDonald John F; Tainer John A; Getzoff Elizabeth D; Crane Brian R; Stuehr Dennis J
Cloning, expression, and characterization of a nitric oxide synthase protein from Deinococcus radiodurans.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(1):107-12.
2002: Blasko Eric; Glaser Charles B; Devlin James J; Xia Wei; Feldman Richard I; Polokoff Mark A; Phillips Gary B; Whitlow Marc; Auld Douglas S; McMillan Kirk; Ghosh Sanjay; Stuehr Dennis J; Parkinson John F
Mechanistic studies with potent and selective inducible nitric-oxide synthase dimerization inhibitors.
The Journal of biological chemistry 2002;277(1):295-302.
2002: Wei Chin-Chuan; Wang Zhi-Qiang; Stuehr Dennis J
Nitric oxide synthase: use of stopped-flow spectroscopy and rapid-quench methods in single-turnover conditions to examine formation and reactions of heme-O2 intermediate in early catalysis.
Methods in enzymology 2002;354():320-38.
2001: Santolini J; Meade A L; Stuehr D J
Differences in three kinetic parameters underpin the unique catalytic profiles of nitric-oxide synthases I, II, and III.
The Journal of biological chemistry 2001;276(52):48887-98.
2001: Aoyagi M; Arvai A S; Ghosh S; Stuehr D J; Tainer J A; Getzoff E D
Structures of tetrahydrobiopterin binding-site mutants of inducible nitric oxide synthase oxygenase dimer and implicated roles of Trp457.
Biochemistry 2001;40(43):12826-32.
2001: Wang Z Q; Wei C C; Ghosh S; Meade A L; Hemann C; Hille R; Stuehr D J
A conserved tryptophan in nitric oxide synthase regulates heme-dioxy reduction by tetrahydrobiopterin.
Biochemistry 2001;40(43):12819-25.
2001: Aulak K S; Miyagi M; Yan L; West K A; Massillon D; Crabb J W; Stuehr D J
Proteomic method identifies proteins nitrated in vivo during inflammatory challenge.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(21):12056-61.
2001: Couture M; Adak S; Stuehr D J; Rousseau D L
Regulation of the properties of the heme-NO complexes in nitric-oxide synthase by hydrogen bonding to the proximal cysteine.
The Journal of biological chemistry 2001;276(41):38280-8.
2001: Dijols S; Perollier C; Lefevre-Groboillot D; Pethe S; Attias R; Boucher J L; Stuehr D J; Mansuy D
Oxidation of N(omega)-hydroxyarginine analogues by NO-synthase: the simple, non amino acid N-butyl N'-hydroxyguanidine is almost as efficient an NO precursor as N(omega)-hydroxyarginine.
Journal of medicinal chemistry 2001;44(20):3199-202.
2001: Zamora R; Vodovotz Y; Alarcon L; Betten B; Loughran P A; Aulak K S; Stuehr D J; Gibson K F; Billiar T R
Nitric oxide from the inducible nitric oxide synthase (iNOS) increases the expression of cytochrome P450 2E1 in iNOS-null hepatocytes in the absence of inflammatory stimuli.
Archives of biochemistry and biophysics 2001;390(2):287-94.
2001: Abu-Soud H M; Ichimori K; Nakazawa H; Stuehr D J
Regulation of inducible nitric oxide synthase by self-generated NO.
Biochemistry 2001;40(23):6876-81.
2001: Panda K; Ghosh S; Stuehr D J
Calmodulin activates intersubunit electron transfer in the neuronal nitric-oxide synthase dimer.
The Journal of biological chemistry 2001;276(26):23349-56.
2001: Adak S; Aulak K S; Stuehr D J
Chimeras of nitric-oxide synthase types I and III establish fundamental correlates between heme reduction, heme-NO complex formation, and catalytic activity.
The Journal of biological chemistry 2001;276(26):23246-52.
2001: Stuehr D; Pou S; Rosen G M
Oxygen reduction by nitric-oxide synthases.
The Journal of biological chemistry 2001;276(18):14533-6.
2001: Adak S; Stuehr D J
A proximal tryptophan in NO synthase controls activity by a novel mechanism.
Journal of inorganic biochemistry 2001;83(4):301-8.
2001: Moali C; Boucher J L; Renodon-Corniere A; Stuehr D J; Mansuy D
Oxidations of N(omega)-hydroxyarginine analogues and various N-hydroxyguanidines by NO synthase II: key role of tetrahydrobiopterin in the reaction mechanism and substrate selectivity.
Chemical research in toxicology 2001;14(2):202-10.
2001: Santolini J; Adak S; Curran C M; Stuehr D J
A kinetic simulation model that describes catalysis and regulation in nitric-oxide synthase.
The Journal of biological chemistry 2001;276(2):1233-43.
2001: Adak S; Santolini J; Tikunova S; Wang Q; Johnson J D; Stuehr D J
Neuronal nitric-oxide synthase mutant (Ser-1412 --> Asp) demonstrates surprising connections between heme reduction, NO complex formation, and catalysis.
The Journal of biological chemistry 2001;276(2):1244-52.
2001: Wei C C; Wang Z Q; Wang Q; Meade A L; Hemann C; Hille R; Stuehr D J
Rapid kinetic studies link tetrahydrobiopterin radical formation to heme-dioxy reduction and arginine hydroxylation in inducible nitric-oxide synthase.
The Journal of biological chemistry 2001;276(1):315-9.
2000: Adak S; Wang Q; Stuehr D J
Arginine conversion to nitroxide by tetrahydrobiopterin-free neuronal nitric-oxide synthase. Implications for mechanism.
The Journal of biological chemistry 2000;275(43):33554-61.
2000: Moali C; Brollo M; Custot J; Sari M A; Boucher J L; Stuehr D J; Mansuy D
Recognition of alpha-amino acids bearing various C=NOH functions by nitric oxide synthase and arginase involves very different structural determinants.
Biochemistry 2000;39(28):8208-18.
2000: Abu-Soud H M; Ichimori K; Presta A; Stuehr D J
Electron transfer, oxygen binding, and nitric oxide feedback inhibition in endothelial nitric-oxide synthase.
The Journal of biological chemistry 2000;275(23):17349-57.
2000: Adak S; Wang Q; Stuehr D J
Molecular basis for hyperactivity in tryptophan 409 mutants of neuronal NO synthase.
The Journal of biological chemistry 2000;275(23):17434-9.
2000: Crane B R; Arvai A S; Ghosh S; Getzoff E D; Stuehr D J; Tainer J A
Structures of the N(omega)-hydroxy-L-arginine complex of inducible nitric oxide synthase oxygenase dimer with active and inactive pterins.
Biochemistry 2000;39(16):4608-21.
2000: Boggs S; Huang L; Stuehr D J
Formation and reactions of the heme-dioxygen intermediate in the first and second steps of nitric oxide synthesis as studied by stopped-flow spectroscopy under single-turnover conditions.
Biochemistry 2000;39(9):2332-9.
1999: Crane B R; Rosenfeld R J; Arvai A S; Ghosh D K; Ghosh S; Tainer J A; Stuehr D J; Getzoff E D
N-terminal domain swapping and metal ion binding in nitric oxide synthase dimerization.
The EMBO journal 1999;18(22):6271-81.
1999: Ghosh D K; Crane B R; Ghosh S; Wolan D; Gachhui R; Crooks C; Presta A; Tainer J A; Getzoff E D; Stuehr D J
Inducible nitric oxide synthase: role of the N-terminal beta-hairpin hook and pterin-binding segment in dimerization and tetrahydrobiopterin interaction.
The EMBO journal 1999;18(22):6260-70.
1999: Abu-Soud H M; Wang J; Rousseau D L; Stuehr D J
Stopped-flow analysis of substrate binding to neuronal nitric oxide synthase.
Biochemistry 1999;38(38):12446-51.
1999: Adak S; Crooks C; Wang Q; Crane B R; Tainer J A; Getzoff E D; Stuehr D J
Tryptophan 409 controls the activity of neuronal nitric-oxide synthase by regulating nitric oxide feedback inhibition.
The Journal of biological chemistry 1999;274(38):26907-11.
1999: Ghosh S; Wolan D; Adak S; Crane B R; Kwon N S; Tainer J A; Getzoff E D; Stuehr D J
Mutational analysis of the tetrahydrobiopterin-binding site in inducible nitric-oxide synthase.
The Journal of biological chemistry 1999;274(34):24100-12.
1999: Adak S; Ghosh S; Abu-Soud H M; Stuehr D J
Role of reductase domain cluster 1 acidic residues in neuronal nitric-oxide synthase. Characterization of the FMN-FREE enzyme.
The Journal of biological chemistry 1999;274(32):22313-20.
1999: Stuehr D J
Mammalian nitric oxide synthases.
Biochimica et biophysica acta 1999;1411(2-3):217-30.
1999: Renodon-Cornière A; Boucher J L; Dijols S; Stuehr D J; Mansuy D
Efficient formation of nitric oxide from selective oxidation of N-aryl N'-hydroxyguanidines by inducible nitric oxide synthase.
Biochemistry 1999;38(15):4663-8.
1999: Huang L; Abu-Soud H M; Hille R; Stuehr D J
Nitric oxide-generated P420 nitric oxide synthase: characterization and roles for tetrahydrobiopterin and substrate in protecting against or reversing the P420 conversion.
Biochemistry 1999;38(6):1912-20.
1999: Sennequier N; Wolan D; Stuehr D J
Antifungal imidazoles block assembly of inducible NO synthase into an active dimer.
The Journal of biological chemistry 1999;274(2):930-8.
1998: Ghosh S; Gachhui R; Crooks C; Wu C; Lisanti M P; Stuehr D J
Interaction between caveolin-1 and the reductase domain of endothelial nitric-oxide synthase. Consequences for catalysis.
The Journal of biological chemistry 1998;273(35):22267-71.
1998: Moali C; Boucher J L; Sari M A; Stuehr D J; Mansuy D
Substrate specificity of NO synthases: detailed comparison of L-arginine, homo-L-arginine, their N omega-hydroxy derivatives, and N omega-hydroxynor-L-arginine.
Biochemistry 1998;37(29):10453-60.
1998: Siddhanta U; Presta A; Fan B; Wolan D; Rousseau D L; Stuehr D J
Domain swapping in inducible nitric-oxide synthase. Electron transfer occurs between flavin and heme groups located on adjacent subunits in the dimer.
The Journal of biological chemistry 1998;273(30):18950-8.
1998: Renodon A; Boucher J L; Wu C; Gachhui R; Sari M A; Mansuy D; Stuehr D
Formation of nitric oxide synthase-iron(II) nitrosoalkane complexes: severe restriction of access to the iron(II) site in the presence of tetrahydrobiopterin.
Biochemistry 1998;37(18):6367-74.
1998: Abu-Soud H M; Wu C; Ghosh D K; Stuehr D J
Stopped-flow analysis of CO and NO binding to inducible nitric oxide synthase.
Biochemistry 1998;37(11):3777-86.
1998: Crane B R; Arvai A S; Ghosh D K; Wu C; Getzoff E D; Stuehr D J; Tainer J A
Structure of nitric oxide synthase oxygenase dimer with pterin and substrate.
Science (New York, N.Y.) 1998;279(5359):2121-6.
1998: Gachhui R; Abu-Soud H M; Ghosha D K; Presta A; Blazing M A; Mayer B; George S E; Stuehr D J
Neuronal nitric-oxide synthase interaction with calmodulin-troponin C chimeras.
The Journal of biological chemistry 1998;273(10):5451-4.
1998: Presta A; Siddhanta U; Wu C; Sennequier N; Huang L; Abu-Soud H M; Erzurum S; Stuehr D J
Comparative functioning of dihydro- and tetrahydropterins in supporting electron transfer, catalysis, and subunit dimerization in inducible nitric oxide synthase.
Biochemistry 1998;37(1):298-310.
1997: Fan B; Wang J; Stuehr D J; Rousseau D L
NO synthase isozymes have distinct substrate binding sites.
Biochemistry 1997;36(42):12660-5.
1997: Crane B R; Arvai A S; Gachhui R; Wu C; Ghosh D K; Getzoff E D; Stuehr D J; Tainer J A
The structure of nitric oxide synthase oxygenase domain and inhibitor complexes.
Science (New York, N.Y.) 1997;278(5337):425-31.
1997: Abu-Soud H M; Presta A; Mayer B; Stuehr D J
Analysis of neuronal NO synthase under single-turnover conditions: conversion of Nomega-hydroxyarginine to nitric oxide and citrulline.
Biochemistry 1997;36(36):10811-6.
1997: Ghosh D K; Wu C; Pitters E; Moloney M; Werner E R; Mayer B; Stuehr D J
Characterization of the inducible nitric oxide synthase oxygenase domain identifies a 49 amino acid segment required for subunit dimerization and tetrahydrobiopterin interaction.
Biochemistry 1997;36(35):10609-19.
1997: Abu-Soud H M; Gachhui R; Raushel F M; Stuehr D J
The ferrous-dioxy complex of neuronal nitric oxide synthase. Divergent effects of L-arginine and tetrahydrobiopterin on its stability.
The Journal of biological chemistry 1997;272(28):17349-53.
1997: Gachhui R; Ghosh D K; Wu C; Parkinson J; Crane B R; Stuehr D J
Mutagenesis of acidic residues in the oxygenase domain of inducible nitric-oxide synthase identifies a glutamate involved in arginine binding.
Biochemistry 1997;36(17):5097-103.
1997: Presta A; Liu J; Sessa W C; Stuehr D J
Substrate binding and calmodulin binding to endothelial nitric oxide synthase coregulate its enzymatic activity.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 1997;1(1):74-87.
1997: Stuehr D J
Structure-function aspects in the nitric oxide synthases.
Annual review of pharmacology and toxicology 1997;37():339-59.
1996: Abu-Soud H M; Rousseau D L; Stuehr D J
Nitric oxide binding to the heme of neuronal nitric-oxide synthase links its activity to changes in oxygen tension.
The Journal of biological chemistry 1996;271(51):32515-8.
1996: Gachhui R; Presta A; Bentley D F; Abu-Soud H M; McArthur R; Brudvig G; Ghosh D K; Stuehr D J
Characterization of the reductase domain of rat neuronal nitric oxide synthase generated in the methylotrophic yeast Pichia pastoris. Calmodulin response is complete within the reductase domain itself.
The Journal of biological chemistry 1996;271(34):20594-602.
1996: Wu C; Zhang J; Abu-Soud H; Ghosh D K; Stuehr D J
High-level expression of mouse inducible nitric oxide synthase in Escherichia coli requires coexpression with calmodulin.
Biochemical and biophysical research communications 1996;222(2):439-44.
1996: Sennequier N; Stuehr D J
Analysis of substrate-induced electronic, catalytic, and structural changes in inducible NO synthase.
Biochemistry 1996;35(18):5883-92.
1996: Siddhanta U; Wu C; Abu-Soud H M; Zhang J; Ghosh D K; Stuehr D J
Heme iron reduction and catalysis by a nitric oxide synthase heterodimer containing one reductase and two oxygenase domains.
The Journal of biological chemistry 1996;271(13):7309-12.
1996: Ghosh D K; Abu-Soud H M; Stuehr D J
Domains of macrophage N(O) synthase have divergent roles in forming and stabilizing the active dimeric enzyme.
Biochemistry 1996;35(5):1444-9.
1995: Abu-Soud H M; Wang J; Rousseau D L; Fukuto J M; Ignarro L J; Stuehr D J
Neuronal nitric oxide synthase self-inactivates by forming a ferrous-nitrosyl complex during aerobic catalysis.
The Journal of biological chemistry 1995;270(39):22997-3006.
1995: Ghosh D K; Abu-Soud H M; Stuehr D J
Reconstitution of the second step in NO synthesis using the isolated oxygenase and reductase domains of macrophage NO synthase.
Biochemistry 1995;34(36):11316-20.
1995: Abu-Soud H M; Loftus M; Stuehr D J
Subunit dissociation and unfolding of macrophage NO synthase: relationship between enzyme structure, prosthetic group binding, and catalytic function.
Biochemistry 1995;34(35):11167-75.
1995: Guo F H; De Raeve H R; Rice T W; Stuehr D J; Thunnissen F B; Erzurum S C
Continuous nitric oxide synthesis by inducible nitric oxide synthase in normal human airway epithelium in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(17):7809-13.
1995: Ghosh D K; Stuehr D J
Macrophage NO synthase: characterization of isolated oxygenase and reductase domains reveals a head-to-head subunit interaction.
Biochemistry 1995;34(3):801-7.
1995: Stuehr D J; Abu-Soud H M; Rousseau D L; Feldman P L; Wang J
Control of electron transfer in neuronal nitric oxide synthase by calmodulin, substrate, substrate analogs, and nitric oxide.
Advances in pharmacology (San Diego, Calif.) 1995;34():207-13.
1994: Abu-Soud H M; Feldman P L; Clark P; Stuehr D J
Electron transfer in the nitric-oxide synthases. Characterization of L-arginine analogs that block heme iron reduction.
The Journal of biological chemistry 1994;269(51):32318-26.
1994: Abu-Soud H M; Yoho L L; Stuehr D J
Calmodulin controls neuronal nitric-oxide synthase by a dual mechanism. Activation of intra- and interdomain electron transfer.
The Journal of biological chemistry 1994;269(51):32047-50.
1993: Abu-Soud H M; Stuehr D J
Nitric oxide synthases reveal a role for calmodulin in controlling electron transfer.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(22):10769-72.
1993: Baek K J; Thiel B A; Lucas S; Stuehr D J
Macrophage nitric oxide synthase subunits. Purification, characterization, and role of prosthetic groups and substrate in regulating their association into a dimeric enzyme.
The Journal of biological chemistry 1993;268(28):21120-9.
1993: Fukuto J M; Stuehr D J; Feldman P L; Bova M P; Wong P
Peracid oxidation of an N-hydroxyguanidine compound: a chemical model for the oxidation of N omega-hydroxyl-L-arginine by nitric oxide synthase.
Journal of medicinal chemistry 1993;36(18):2666-70.
1993: Deng W; Thiel B; Tannenbaum C S; Hamilton T A; Stuehr D J
Synergistic cooperation between T cell lymphokines for induction of the nitric oxide synthase gene in murine peritoneal macrophages.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(1):322-9.
1993: Feldman P L; Griffith O W; Hong H; Stuehr D J
Irreversible inactivation of macrophage and brain nitric oxide synthase by L-NG-methylarginine requires NADPH-dependent hydroxylation.
Journal of medicinal chemistry 1993;36(4):491-6.
1992: Stuehr D J; Ikeda-Saito M
Spectral characterization of brain and macrophage nitric oxide synthases. Cytochrome P-450-like hemeproteins that contain a flavin semiquinone radical.
The Journal of biological chemistry 1992;267(29):20547-50.
1992: Stuehr D J; Griffith O W
Mammalian nitric oxide synthases.
Advances in enzymology and related areas of molecular biology 1992;65():287-346.
1991: Kwon N S; Stuehr D J; Nathan C F
Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide.
The Journal of experimental medicine 1991;174(4):761-7.
1991: Stuehr D J; Cho H J; Kwon N S; Weise M F; Nathan C F
Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(17):7773-7.
1991: Stuehr D J; Kwon N S; Nathan C F; Griffith O W; Feldman P L; Wiseman J
N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine.
The Journal of biological chemistry 1991;266(10):6259-63.
1991: Stuehr D J; Fasehun O A; Kwon N S; Gross S S; Gonzalez J A; Levi R; Nathan C F
Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1991;5(1):98-103.
1990: Kwon N S; Nathan C F; Gilker C; Griffith O W; Matthews D E; Stuehr D J
L-citrulline production from L-arginine by macrophage nitric oxide synthase. The ureido oxygen derives from dioxygen.
The Journal of biological chemistry 1990;265(23):13442-5.
1990: Nathan C F; Stuehr D J
Does endothelium-derived nitric oxide have a role in cytokine-induced hypotension?
Journal of the National Cancer Institute 1990;82(9):726-8.
1990: Stuehr D J; Kwon N S; Nathan C F
FAD and GSH participate in macrophage synthesis of nitric oxide.
Biochemical and biophysical research communications 1990;168(2):558-65.
1989: Kwon N S; Nathan C F; Stuehr D J
Reduced biopterin as a cofactor in the generation of nitrogen oxides by murine macrophages.
The Journal of biological chemistry 1989;264(34):20496-501.
1989: Stuehr D J; Kwon N S; Gross S S; Thiel B A; Levi R; Nathan C F
Synthesis of nitrogen oxides from L-arginine by macrophage cytosol: requirement for inducible and constitutive components.
Biochemical and biophysical research communications 1989;161(2):420-6.
1989: Stuehr D J; Nathan C F
Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.
The Journal of experimental medicine 1989;169(5):1543-55.
1989: Stuehr D J; Gross S S; Sakuma I; Levi R; Nathan C F
Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide.
The Journal of experimental medicine 1989;169(3):1011-20.

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