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Dennis Stuehr

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Mohammad Mahfuzul Haque; Mekki Bayachou; Deborah Durra; Mohammed A Fadlalla; Dennis J Stuehr
Charge-pairing interactions control the conformational setpoint and motions of the FMN domain in neuronal nitric oxide synthase.
Joseph Sabat; Dennis J Stuehr; Tsuyoshi Egawa; Gary J Gerfen; Changyuan Lu; Denis L Rousseau; Syun-Ru Yeh
Catalytic intermediates of inducible nitric-oxide synthase stabilized by the W188H mutation.
Kyle C McKenna; Rebecca C Scherder; Kelly M Beatty; Alex F Chen; Arnab Ghosh; Fuwang Li; Huanbo Liu; Dennis J Stuehr
Ascorbate in aqueous humor augments nitric oxide production by macrophages.

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2013: Mohammad Mahfuzul Haque; Mekki Bayachou; Deborah Durra; Mohammed A Fadlalla; Dennis J Stuehr
Charge-pairing interactions control the conformational setpoint and motions of the FMN domain in neuronal nitric oxide synthase.
The Biochemical journal 2013;450(3):607-17.
2013: Joseph Sabat; Dennis J Stuehr; Tsuyoshi Egawa; Gary J Gerfen; Changyuan Lu; Denis L Rousseau; Syun-Ru Yeh
Catalytic intermediates of inducible nitric-oxide synthase stabilized by the W188H mutation.
The Journal of biological chemistry 2013;288(9):6095-106.
2013: Kyle C McKenna; Rebecca C Scherder; Kelly M Beatty; Alex F Chen; Arnab Ghosh; Fuwang Li; Huanbo Liu; Dennis J Stuehr
Ascorbate in aqueous humor augments nitric oxide production by macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(2):556-64.
2012: Luciana Hannibal; Jérôme Santolini; Rajesh Vempati; Julie Brassard; Ritu Chakravarti; Daniel Collins; John H Dawson; Pierre Dorlet; Dennis J Stuehr
Heme binding properties of glyceraldehyde-3-phosphate dehydrogenase.
Biochemistry 2012;51(43):8514-29.
2012: Mohammad Mahfuzul Haque; kulwant aulak; Deborah Durra; Mohammed A Fadlalla; Arnab Ghosh; Dennis J Stuehr
Control of electron transfer and catalysis in neuronal nitric-oxide synthase (nNOS) by a hinge connecting its FMN and FAD-NADPH domains.
The Journal of biological chemistry 2012;287(36):30105-16.
2012: Jie Jia; Jonathan D Smith; Dennis J Stuehr; Belinda Willard; Abul Arif; Stanley L Hazen; Paul L Fox
Protection of extraribosomal RPL13a by GAPDH and dysregulation by S-nitrosylation.
Molecular cell 2012;47(4):656-63.
2012: Arnab Ghosh; Dennis J Stuehr
Soluble guanylyl cyclase requires heat shock protein 90 for heme insertion during maturation of the NO-active enzyme.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(32):12998-3003.
2012: Ritu Chakravarti; Dennis J Stuehr
Thioredoxin-1 regulates cellular heme insertion by controlling S-nitrosation of glyceraldehyde-3-phosphate dehydrogenase.
The Journal of biological chemistry 2012;287(20):16179-86.
2012: Zhi-Qiang Wang; Chin-Chuan Wei; Jesus Tejero; Ashis Biswas; Mohammed Fadlalla; Mohammad Mahfuzul Haque; Jerome Santolini; Dennis J Stuehr
Arg375 tunes tetrahydrobiopterin functions and modulates catalysis by inducible nitric oxide synthase.
Journal of inorganic biochemistry 2012;108():203-15.
2012: Chin-Chuan Wei; Kristen Wetherell; Ya-Ping Yang; Zhi-Qiang Wang; Tiffany Boyle; Christina Palka; Nicole Reynolds; Dennis J Stuehr
Characterization of the 1st and 2nd EF-hands of NADPH oxidase 5 by fluorescence, isothermal titration calorimetry, and circular dichroism.
Chemistry Central journal 2012;6(1):29.
2011: Luciana Hannibal; Ramasamy Somasundaram; Jesus Tejero; Adjele Wilson; Dennis J Stuehr
Influence of heme-thiolate in shaping the catalytic properties of a bacterial nitric-oxide synthase.
The Journal of biological chemistry 2011;286(45):39224-35.
2011: Mohammad Mahfuzul Haque; Claire Kenney; Jesus Tejero; Dennis J Stuehr
A kinetic model linking protein conformational motions, interflavin electron transfer and electron flux through a dual-flavin enzyme-simulating the reductase activity of the endothelial and neuronal nitric oxide synthase flavoprotein domains.
The FEBS journal 2011;278(21):4055-69.
2011: Arnab Ghosh; Mamta Chawla-Sarkar; Dennis J Stuehr
Hsp90 interacts with inducible NO synthase client protein in its heme-free state and then drives heme insertion by an ATP-dependent process.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(6):2049-60.
2011: Jesus Tejero; Ashis Biswas; Mohammad Mahfuzul Haque; Zhi-Qiang Wang; Craig Hemann; Cornelius L Varnado; Zachary Novince; Russ Hille; Douglas C Goodwin; Dennis J Stuehr
Mesohaem substitution reveals how haem electronic properties can influence the kinetic and catalytic parameters of neuronal NO synthase.
The Biochemical journal 2011;433(1):163-74.
2010: Ritu Chakravarti; kulwant aulak; Paul L Fox; Dennis J Stuehr
GAPDH regulates cellular heme insertion into inducible nitric oxide synthase.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(42):18004-9.
2010: Amandine Maréchal; Tony A Mattioli; Dennis J Stuehr; Jerome Santolini
NO synthase isoforms specifically modify peroxynitrite reactivity.
The FEBS journal 2010;277(19):3963-73.
2010: Jesus Tejero; Luciana Hannibal; Anthony Mustovich; Dennis J Stuehr
Surface charges and regulation of FMN to heme electron transfer in nitric-oxide synthase.
The Journal of biological chemistry 2010;285(35):27232-40.
2010: Jesus Tejero; Mohammad Mahfuzul Haque; Deborah Durra; Dennis J Stuehr
A bridging interaction allows calmodulin to activate NO synthase through a bi-modal mechanism.
The Journal of biological chemistry 2010;285(34):25941-9.
2010: Syed Mohsin Waheed; Arnab Ghosh; Ritu Chakravarti; Ashis Biswas; Mohammad Mahfuzul Haque; Koustubh Panda; Dennis J Stuehr
Nitric oxide blocks cellular heme insertion into a broad range of heme proteins.
Free radical biology & medicine 2010;48(11):1548-58.
2010: Claire Giroud; Magali Moreau; Tony A Mattioli; Véronique Balland; Jean-Luc Boucher; Yun Xu-Li; Dennis J Stuehr; Jérôme Santolini
Role of arginine guanidinium moiety in nitric-oxide synthase mechanism of oxygen activation.
The Journal of biological chemistry 2010;285(10):7233-45.
2010: Zhi-Qiang Wang; Chin-Chuan Wei; Dennis J Stuehr
How does a valine residue that modulates heme-NO binding kinetics in inducible NO synthase regulate enzyme catalysis?
Journal of inorganic biochemistry 2010;104(3):349-56.
2010: Zhi-Wen Guan; Mohammad Mahfuzul Haque; Chin-Chuan Wei; Elsa D Garcin; Elizabeth D Getzoff; Dennis J Stuehr
Lys842 in neuronal nitric-oxide synthase enables the autoinhibitory insert to antagonize calmodulin binding, increase FMN shielding, and suppress interflavin electron transfer.
The Journal of biological chemistry 2010;285(5):3064-75.
2010: Chin-Chuan Wei; Nicole Motl; Kelli Levek; Liu Qi Chen; Ya-Ping Yang; Tremylla Johnson; Lindsey Hamilton; Dennis J Stuehr
Conformational States and kinetics of the calcium binding domain of NADPH oxidase 5.
The open biochemistry journal 2010;4():59-67.
2009: Joseph Sabat; Dennis J Stuehr; Syun-Ru Yeh; Denis L Rousseau
Characterization of the proximal ligand in the P420 form of inducible nitric oxide synthase.
Journal of the American Chemical Society 2009;131(34):12186-92.
2009: Jesus Tejero; Jerome Santolini; Dennis J Stuehr
Fast ferrous heme-NO oxidation in nitric oxide synthases.
The FEBS journal 2009;276(16):4505-14.
2009: Dennis J Stuehr; Jesus Tejero; Mohammad Mahfuzul Haque
Structural and mechanistic aspects of flavoproteins: electron transfer through the nitric oxide synthase flavoprotein domain.
The FEBS journal 2009;276(15):3959-74.
2009: Mohammad Mahfuzul Haque; Mohammed Fadlalla; Zhi-Qiang Wang; Sougata Sinha Ray; Koustubh Panda; Dennis J Stuehr
Neutralizing a surface charge on the FMN subdomain increases the activity of neuronal nitric-oxide synthase by enhancing the oxygen reactivity of the enzyme heme-nitric oxide complex.
The Journal of biological chemistry 2009;284(29):19237-47.
2009: Robielyn P Ilagan; Jesus Tejero; kulwant aulak; Sougata Sinha Ray; Craig Hemann; Zhi-Qiang Wang; Mahinda Gangoda; Jay L Zweier; Dennis J Stuehr
Regulation of FMN subdomain interactions and function in neuronal nitric oxide synthase.
Biochemistry 2009;48(18):3864-76.
2009: Baochen Fan; Dennis J Stuehr; Denis L Rousseau
Role of substrate functional groups in binding to nitric oxide synthase.
Biochemical and biophysical research communications 2009;382(1):21-5.
2009: Thomas Koeck; John A Corbett; John W Crabb; Dennis J Stuehr; kulwant aulak
Glucose-modulated tyrosine nitration in beta cells: targets and consequences.
Archives of biochemistry and biophysics 2009;484(2):221-31.
2009: Thomas Koeck; Belinda Willard; John W Crabb; Michael Kinter; Dennis J Stuehr; Kulwant S Aulak
Glucose-mediated tyrosine nitration in adipocytes: targets and consequences.
Free radical biology & medicine 2009;46(7):884-92.
2009: Joanna Wegrzyn; Ramesh Potla; Yong-Joon Chwae; Naresh B V Sepuri; Qifang Zhang; Thomas Koeck; Marta Derecka; Karol Szczepanek; Magdalena Szelag; Agnieszka Gornicka; Akira Moh; Shadi Moghaddas; Qun Chen; Santha Bobbili; Joanna Cichy; Jozef Dulak; Darren P Baker; Alan Wolfman; Dennis J Stuehr; Medhat O Hassan; Xin-Yuan Fu; Narayan G Avadhani; Jennifer I Drake; Paul Fawcett; Edward J Lesnefsky; Andrew C Larner
Function of mitochondrial Stat3 in cellular respiration.
Science (New York, N.Y.) 2009;323(5915):793-7.
2008: Jesus Tejero; Ashis Biswas; Zhi-Qiang Wang; Richard C Page; Mohammad Mahfuzul Haque; Craig Hemann; Jay L Zweier; Saurav Misra; Dennis J Stuehr
Stabilization and characterization of a heme-oxy reaction intermediate in inducible nitric-oxide synthase.
The Journal of biological chemistry 2008;283(48):33498-507.
2008: Elsa D Garcin; Andrew S Arvai; Robin J Rosenfeld; Matt D Kroeger; Brian R Crane; Gunilla Andersson; Glen Andrews; Peter J Hamley; Philip R Mallinder; David J Nicholls; Stephen A St-Gallay; Alan C Tinker; Nigel P Gensmantel; Antonio Mete; David R Cheshire; Stephen Connolly; Dennis J Stuehr; Anders Aberg; Alan V Wallace; John A Tainer; Elizabeth D Getzoff
Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase.
Nature chemical biology 2008;4(11):700-7.
2008: Sonia Donzelli; Michael G Espey; Wilmarie Flores-Santana; Christopher H Switzer; Grace C Yeh; Jinming Huang; Dennis J Stuehr; S Bruce King; Katrina M Miranda; David A Wink
Generation of nitroxyl by heme protein-mediated peroxidation of hydroxylamine but not N-hydroxy-L-arginine.
Free radical biology & medicine 2008;45(5):578-84.
2008: Robielyn P Ilagan; Mauro Tiso; David W Konas; Craig Hemann; Deborah Durra; Russ Hille; Dennis J Stuehr
Differences in a conformational equilibrium distinguish catalysis by the endothelial and neuronal nitric-oxide synthase flavoproteins.
The Journal of biological chemistry 2008;283(28):19603-15.
2008: Betty Cottyn; Francine Acher; Booma Ramassamy; Luke Alvey; Michel Lepoivre; Yves-Michel Frapart; Dennis J Stuehr; Daniel Mansuy; Jean-Luc Boucher; Dominique Vichard
Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: particular potency of 1H-indazole-7-carbonitrile.
Bioorganic & medicinal chemistry 2008;16(11):5962-73.
2008: Ivan Gusarov; Marina Starodubtseva; Zhi-Qiang Wang; Lindsey McQuade; Stephen J Lippard; Dennis J Stuehr; Evgeny Nudler
Bacterial nitric-oxide synthases operate without a dedicated redox partner.
The Journal of biological chemistry 2008;283(19):13140-7.
2008: Chin-Chuan Wei; Zhi-Qiang Wang; Jesus Tejero; Ya-Ping Yang; Craig Hemann; Russ Hille; Dennis J Stuehr
Catalytic reduction of a tetrahydrobiopterin radical within nitric-oxide synthase.
The Journal of biological chemistry 2008;283(17):11734-42.
2008: Alexia Chandor; Sylvie Dijols; Booma Ramassamy; Yves-Michel Frapart; Daniel Mansuy; Dennis J Stuehr; Nuala Helsby; Jean-Luc Boucher
Metabolic activation of the antitumor drug 5-(Aziridin-1-yl)-2,4-dinitrobenzamide (CB1954) by NO synthases.
Chemical research in toxicology 2008;21(4):836-43.
2008: Mauro Tiso; Andreas Strub; Christian Hesslinger; Claire T Kenney; Rainer Boer; Dennis J Stuehr
BYK191023 (2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3h-imidazo[4,5-b]pyridine) is an NADPH- and time-dependent irreversible inhibitor of inducible nitric-oxide synthase.
Molecular pharmacology 2008;73(4):1244-53.
2007: Mauro Tiso; Jesus Tejero; Koustubh Panda; kulwant aulak; Dennis J Stuehr
Versatile regulation of neuronal nitric oxide synthase by specific regions of its C-terminal tail.
Biochemistry 2007;46(50):14418-28.
2007: Edward Beaumont; Jean-Christophe Lambry; Zhi-Qiang Wang; Dennis J Stuehr; Jean-Louis Martin; Anny SLAMA-SCHWOK
Distal Val346Ile mutation in inducible NO synthase promotes substrate-dependent NO confinement.
Biochemistry 2007;46(47):13533-40.
2007: Serpil C Erzurum; Sudakshina Ghosh; Allison J Janocha; Weiling Xu; S Bauer; Nathan S Bryan; Jesus Tejero; Craig Hemann; Russ Hille; Dennis J Stuehr; Martin Feelisch; Cynthia M Beall
Higher blood flow and circulating NO products offset high-altitude hypoxia among Tibetans.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(45):17593-8.
2007: Sougata Sinha Ray; Rajib Sengupta; Mauro Tiso; Mohammad Mahfuzul Haque; Rupam Sahoo; David W Konas; kulwant aulak; Michael Regulski; Tim Tully; Dennis J Stuehr; Sanjay Ghosh
Reductase domain of Drosophila melanogaster nitric-oxide synthase: redox transformations, regulation, and similarity to mammalian homologues.
Biochemistry 2007;46(42):11865-73.
2007: Sougata Sinha Ray; Jesus Tejero; Zhi-Qiang Wang; Tanmay Dutta; Arindam Bhattacharjee; Michael Regulski; Tim Tully; Sanjay Ghosh; Dennis J Stuehr
Oxygenase domain of Drosophila melanogaster nitric oxide synthase: unique kinetic parameters enable a more efficient NO release.
Biochemistry 2007;46(42):11857-64.
2007: David Li; Mariam Kabir; Dennis J Stuehr; Denis L Rousseau; Syun-Ru Yeh
Substrate- and isoform-specific dioxygen complexes of nitric oxide synthase.
Journal of the American Chemical Society 2007;129(21):6943-51.
2007: Mohammad Mahfuzul Haque; Koustubh Panda; Jesus Tejero; kulwant aulak; Mohammed Adam Fadlalla; Anthony T Mustovich; Dennis J Stuehr
A connecting hinge represses the activity of endothelial nitric oxide synthase.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(22):9254-9.
2007: Amandine Maréchal; Tony A Mattioli; Dennis J Stuehr; Jérôme Santolini
Activation of peroxynitrite by inducible nitric-oxide synthase: a direct source of nitrative stress.
The Journal of biological chemistry 2007;282(19):14101-12.
2007: Davin Jagnandan; Jarrod E Church; Botond Banfi; Dennis J Stuehr; Mario B Marrero; David J Fulton
Novel mechanism of activation of NADPH oxidase 5. calcium sensitization via phosphorylation.
The Journal of biological chemistry 2007;282(9):6494-507.
2007: Zhi-Qiang Wang; Rachel J Lawson; Madhavan R Buddha; Chin-Chuan Wei; Brian R Crane; Andrew W Munro; Dennis J Stuehr
Bacterial flavodoxins support nitric oxide production by Bacillus subtilis nitric-oxide synthase.
The Journal of biological chemistry 2007;282(4):2196-202.
2007: Weiling Xu; Thomas Koeck; Abigail R Lara; Donald Neumann; Frank P DiFilippo; Michelle Koo; Allison J Janocha; Fares A Masri; Alejandro C Arroliga; Constance Jennings; raed dweik; Rubin M Tuder; Dennis J Stuehr; Serpil C Erzurum
Alterations of cellular bioenergetics in pulmonary artery endothelial cells.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(4):1342-7.
2006: Koustubh Panda; Mohammad Mahfuzul Haque; Elsa D Garcin-Hosfield; Deborah Durra; Elizabeth D Getzoff; Dennis J Stuehr
Surface charge interactions of the FMN module govern catalysis by nitric-oxide synthase.
The Journal of biological chemistry 2006;281(48):36819-27.
2006: Ramesh Potla; Thomas Koeck; Joanna Wegrzyn; Srujana Cherukuri; Kazuya Shimoda; Darren P Baker; Janice C Wolfman; Sarah M Planchon; Christine Esposito; Brian Hoit; Jozef Dulak; Alan Wolfman; Dennis J Stuehr; Andrew C Larner
Tyk2 tyrosine kinase expression is required for the maintenance of mitochondrial respiration in primary pro-B lymphocytes.
Molecular and cellular biology 2006;26(22):8562-71.
2006: David W Konas; Naoki Takaya; Manisha Sharma; Dennis J Stuehr
Role of Asp1393 in catalysis, flavin reduction, NADP(H) binding, FAD thermodynamics, and regulation of the nNOS flavoprotein.
Biochemistry 2006;45(41):12596-609.
2006: Magali Moreau; Jean-Luc Boucher; Tony A Mattioli; Dennis J Stuehr; Daniel Mansuy; Jérôme Santolini
Differential effects of alkyl- and arylguanidines on the stability and reactivity of inducible NOS heme-dioxygen complexes.
Biochemistry 2006;45(12):3988-99.
2006: David Li; Eric Y Hayden; Koustubh Panda; Dennis J Stuehr; Haiteng Deng; Denis L Rousseau; Syun-Ru Yeh
Regulation of the monomer-dimer equilibrium in inducible nitric-oxide synthase by nitric oxide.
The Journal of biological chemistry 2006;281(12):8197-204.
2006: Jérôme Santolini; Miruna Roman; Dennis J Stuehr; Tony A Mattioli
Resonance Raman study of Bacillus subtilis NO synthase-like protein: similarities and differences with mammalian NO synthases.
Biochemistry 2006;45(5):1480-9.
2006: David Lefèvre-Groboillot; Jean-Luc Boucher; Daniel Mansuy; Dennis J Stuehr
Reactivity of the heme-dioxygen complex of the inducible nitric oxide synthase in the presence of alternative substrates.
The FEBS journal 2006;273(1):180-91.
2005: Thomas Koeck; Dennis J Stuehr; kulwant aulak
Mitochondria and regulated tyrosine nitration.
Biochemical Society transactions 2005;33(Pt 6):1399-403.
2005: Mauro Tiso; David W Konas; Koustubh Panda; Elsa D Garcin; Manisha Sharma; Elizabeth D Getzoff; Dennis J Stuehr
C-terminal tail residue Arg1400 enables NADPH to regulate electron transfer in neuronal nitric-oxide synthase.
The Journal of biological chemistry 2005;280(47):39208-19.
2005: Wendy Belliston-Bittner; Alexander R Dunn; Yen Hoang Le Nguyen; Dennis J Stuehr; Jay R Winkler; Harry B Gray
Picosecond photoreduction of inducible nitric oxide synthase by rhenium(I)-diimine wires.
Journal of the American Chemical Society 2005;127(45):15907-15.
2005: Dennis J Stuehr; Chin-Chuan Wei; Zhiqiang Wang; Russ Hille
Exploring the redox reactions between heme and tetrahydrobiopterin in the nitric oxide synthases.
Dalton transactions (Cambridge, England : 2003) 2005;(21):3427-35.
2005: Fares A Masri; Suzy A A Comhair; Thomas Koeck; Weiling Xu; Allison J Janocha; Sudakshina Ghosh; raed dweik; Joseph A Golish; Michael Kinter; Dennis J Stuehr; Serpil C Erzurum; kulwant aulak
Abnormalities in nitric oxide and its derivatives in lung cancer.
American journal of respiratory and critical care medicine 2005;172(5):597-605.
2005: Koustubh Panda; Mamta Chawla-Sarkar; Cecile Santos; Thomas Koeck; Serpil C Erzurum; John Parkinson; Dennis J Stuehr
Visualizing inducible nitric-oxide synthase in living cells with a heme-binding fluorescent inhibitor.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(29):10117-22.
2005: David Lefèvre-Groboillot; Jean-Luc Boucher; Dennis J Stuehr; Daniel Mansuy
Relationship between the structure of guanidines and N-hydroxyguanidines, their binding to inducible nitric oxide synthase (iNOS) and their iNOS-catalysed oxidation to NO.
The FEBS journal 2005;272(12):3172-83.
2005: Alexander R Dunn; Wendy Belliston-Bittner; Jay R Winkler; Elizabeth D Getzoff; Dennis J Stuehr; Harry B Gray
Luminescent ruthenium(II)- and rhenium(I)-diimine wires bind nitric oxide synthase.
Journal of the American Chemical Society 2005;127(14):5169-73.
2005: Bennie H Jeng; Karen G Shadrach; David M Meisler; Joe G Hollyfield; Jason Connor; Thomas Koeck; kulwant aulak; Dennis J Stuehr
Immunohistochemical detection and Western blot analysis of nitrated protein in stored human corneal epithelium.
Experimental eye research 2005;80(4):509-14.
2005: Zhi-Qiang Wang; Chin-Chuan Wei; Jerome Santolini; Koustubh Panda; Qian Wang; Dennis J Stuehr
A tryptophan that modulates tetrahydrobiopterin-dependent electron transfer in nitric oxide synthase regulates enzyme catalysis by additional mechanisms.
Biochemistry 2005;44(12):4676-90.
2005: Chin-Chuan Wei; Zhi-Qiang Wang; Deborah Durra; Craig Hemann; Russ Hille; Elsa D Garcin; Elizabeth D Getzoff; Dennis J Stuehr
The three nitric-oxide synthases differ in their kinetics of tetrahydrobiopterin radical formation, heme-dioxy reduction, and arginine hydroxylation.
The Journal of biological chemistry 2005;280(10):8929-35.
2004: Dennis J Stuehr
Enzymes of the L-arginine to nitric oxide pathway.
The Journal of nutrition 2004;134(10 Suppl):2748S-2751S; discussion 2765S-2767S.
2004: Elsa D Garcin; Christopher M Bruns; Sarah J Lloyd; David J Hosfield; Mauro Tiso; Ratan Gachhui; Dennis J Stuehr; John A Tainer; Elizabeth D Getzoff
Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase.
The Journal of biological chemistry 2004;279(36):37918-27.
2004: Dennis J Stuehr; Jerome Santolini; Zhi-Qiang Wang; Chin-Chuan Wei; Subrata Adak
Update on mechanism and catalytic regulation in the NO synthases.
The Journal of biological chemistry 2004;279(35):36167-70.
2004: David W Konas; Keng Zhu; Manisha Sharma; kulwant aulak; Gary W Brudvig; Dennis J Stuehr
The FAD-shielding residue Phe1395 regulates neuronal nitric-oxide synthase catalysis by controlling NADP+ affinity and a conformational equilibrium within the flavoprotein domain.
The Journal of biological chemistry 2004;279(34):35412-25.
2004: Thomas Koeck; Xiaoming Fu; Stanley L Hazen; John W Crabb; Dennis J Stuehr; kulwant aulak
Rapid and selective oxygen-regulated protein tyrosine denitration and nitration in mitochondria.
The Journal of biological chemistry 2004;279(26):27257-62.
2004: David Li; Dennis J Stuehr; Syun-Ru Yeh; Denis L Rousseau
Heme distortion modulated by ligand-protein interactions in inducible nitric-oxide synthase.
The Journal of biological chemistry 2004;279(25):26489-99.
2004: Thomas Koeck; Bruce Levison; Stanley L Hazen; John W Crabb; Dennis J Stuehr; kulwant aulak
Tyrosine nitration impairs mammalian aldolase A activity.
Molecular & cellular proteomics : MCP 2004;3(6):548-57.
2004: Zhi-Qiang Wang; Chin-Chuan Wei; Manisha Sharma; Kartikeya Pant; Brian R Crane; Dennis J Stuehr
A conserved Val to Ile switch near the heme pocket of animal and bacterial nitric-oxide synthases helps determine their distinct catalytic profiles.
The Journal of biological chemistry 2004;279(18):19018-25.
2004: Koustubh Panda; Subrata Adak; David W Konas; Manisha Sharma; Dennis J Stuehr
A conserved aspartate (Asp-1393) regulates NADPH reduction of neuronal nitric-oxide synthase: implications for catalysis.
The Journal of biological chemistry 2004;279(18):18323-33.
2004: David M Meisler; Thomas Koeck; Jason Connor; kulwant aulak; Bennie H Jeng; Joe G Hollyfield; Dennis J Stuehr; Karen G Shadrach
Inhibition of nitric oxide synthesis in corneas in storage media.
Experimental eye research 2004;78(4):891-4.
2004: Clément Gautier; Michel Négrerie; Zhi-Qiang Wang; Jean-Christophe Lambry; Dennis J Stuehr; Fabrice Collin; Jean-Louis Martin; Anny SLAMA-SCHWOK
Dynamic regulation of the inducible nitric-oxide synthase by NO: comparison with the endothelial isoform.
The Journal of biological chemistry 2004;279(6):4358-65.
2004: Dennis J Stuehr; Chin-Chuan Wei; Jerome Santolini; Zhi- Qiang Wang; Mika Aoyagi; Elizabeth D Getzoff
Radical reactions of nitric oxide synthases.
Biochemical Society symposium 2004;(71):39-49.
2004: kulwant aulak; Thomas Koeck; John W Crabb; Dennis J Stuehr
Proteomic method for identification of tyrosine-nitrated proteins.
Methods in molecular biology (Clifton, N.J.) 2004;279():151-65.
2004: kulwant aulak; Thomas Koeck; John W Crabb; Dennis J Stuehr
Dynamics of protein nitration in cells and mitochondria.
American journal of physiology. Heart and circulatory physiology 2004;286(1):H30-8.
2003: Kjetil Ask; Sylvie Dijols; C Giroud; L Casse; Yves-Michel Frapart; Marie-Agnès Sari; K-S Kim; Dennis J Stuehr; Daniel Mansuy; Philippe Camus; Jean-Luc Boucher
Reduction of nilutamide by NO synthases: implications for the adverse effects of this nitroaromatic antiandrogen drug.
Chemical research in toxicology 2003;16(12):1547-54.
2003: Chin-Chuan Wei; Zhi-Qiang Wang; Craig Hemann; Russ Hille; Dennis J Stuehr
A tetrahydrobiopterin radical forms and then becomes reduced during Nomega-hydroxyarginine oxidation by nitric-oxide synthase.
The Journal of biological chemistry 2003;278(47):46668-73.
2003: Tomohiro Sawa; Takaaki Akaike; Koji Ichimori; Teruo Akuta; Kazuyoshi Kaneko; Hitoshi Nakayama; Dennis J Stuehr; Hiroshi Maeda
Superoxide generation mediated by 8-nitroguanosine, a highly redox-active nucleic acid derivative.
Biochemical and biophysical research communications 2003;311(2):300-6.
2003: Koustubh Panda; Subrata Adak; kulwant aulak; Jerome Santolini; John F McDonald; Dennis J Stuehr
Distinct influence of N-terminal elements on neuronal nitric-oxide synthase structure and catalysis.
The Journal of biological chemistry 2003;278(39):37122-31.
2003: Illarion V Turko; Li Li; kulwant aulak; Dennis J Stuehr; Jui-Yoa Chang; Ferid Murad
Protein tyrosine nitration in the mitochondria from diabetic mouse heart. Implications to dysfunctional mitochondria in diabetes.
The Journal of biological chemistry 2003;278(36):33972-7.
2003: Rajib Sengupta; Rupam Sahoo; Shaeri Mukherjee; Michael Regulski; Tim Tully; Dennis J Stuehr; Sanjay Ghosh
Characterization of Drosophila nitric oxide synthase: a biochemical study.
Biochemical and biophysical research communications 2003;306(2):590-7.
2003: Chin-Chuan Wei; Brian R Crane; Dennis J Stuehr
Tetrahydrobiopterin radical enzymology.
Chemical reviews 2003;103(6):2365-83.
2003: David Lefèvre-Groboillot; Yves-Michel Frapart; Alain Desbois; Jean-Luc Zimmermann; Jean-Luc Boucher; Antonius C F Gorren; Bernd Mayer; Dennis J Stuehr; Daniel Mansuy
Two modes of binding of N-hydroxyguanidines to NO synthases: first evidence for the formation of iron-N-hydroxyguanidine complexes and key role of tetrahydrobiopterin in determining the binding mode.
Biochemistry 2003;42(13):3858-67.
2003: Heather L Voegtle; Masanori Sono; Subrata Adak; Alycen E Pond; Takeshi Tomita; Roshan Perera; David B Goodin; Masao Ikeda-Saito; Dennis J Stuehr; John H Dawson
Spectroscopic characterization of five- and six-coordinate ferrous-NO heme complexes. Evidence for heme Fe-proximal cysteinate bond cleavage in the ferrous-NO adducts of the Trp-409Tyr/Phe proximal environment mutants of neuronal nitric oxide synthase.
Biochemistry 2003;42(8):2475-84.
2003: Chin-Chuan Wei; Zhi-Qiang Wang; Andrew S Arvai; Craig Hemann; Russ Hille; Elizabeth D Getzoff; Dennis J Stuehr
Structure of tetrahydrobiopterin tunes its electron transfer to the heme-dioxy intermediate in nitric oxide synthase.
Biochemistry 2003;42(7):1969-77.
2002: Robin J Rosenfeld; Elsa D Garcin; Koustubh Panda; Gunilla Andersson; Anders Aberg; Alan V Wallace; Garrett M Morris; Arthur J Olson; Dennis J Stuehr; John A Tainer; Elizabeth D Getzoff
Conformational changes in nitric oxide synthases induced by chlorzoxazone and nitroindazoles: crystallographic and computational analyses of inhibitor potency.
Biochemistry 2002;41(47):13915-25.
2002: Ruben Zamora; Yoram Vodovotz; kulwant aulak; Peter K M Kim; John M Kane; Louis Alarcon; Dennis J Stuehr; Timothy R Billiar
A DNA microarray study of nitric oxide-induced genes in mouse hepatocytes: implications for hepatic heme oxygenase-1 expression in ischemia/reperfusion.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2002;7(3):165-86.
2002: Subrata Adak; Manisha Sharma; Abigail L Meade; Dennis J Stuehr
A conserved flavin-shielding residue regulates NO synthase electron transfer and nicotinamide coenzyme specificity.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(21):13516-21.
2002: Chin-Chuan Wei; Zhi-Qiang Wang; Abigail L Meade; John F McDonald; Dennis J Stuehr
Why do nitric oxide synthases use tetrahydrobiopterin?
Journal of inorganic biochemistry 2002;91(4):618-24.
2002: Kartikeya Pant; Alexandrine M Bilwes; Subrata Adak; Dennis J Stuehr; Brian R Crane
Structure of a nitric oxide synthase heme protein from Bacillus subtilis.
Biochemistry 2002;41(37):11071-9.
2002: Koustubh Panda; Robin J Rosenfeld; Sanjay Ghosh; Abigail L Meade; Elizabeth D Getzoff; Dennis J Stuehr
Distinct dimer interaction and regulation in nitric-oxide synthase types I, II, and III.
The Journal of biological chemistry 2002;277(34):31020-30.
2002: Sylvie Dijols; Jean-Luc Boucher; Michel Lepoivre; David Lefevre-Groboillot; Magali Moreau; Yves-Michel Frapart; Eleni A Rekka; Abigail L Meade; Dennis J Stuehr; Daniel Mansuy
First non-alpha-amino acid guanidines acting as efficient NO precursors upon oxidation by NO-synthase II or activated mouse macrophages.
Biochemistry 2002;41(30):9286-92.
2002: Subrata Adak; kulwant aulak; Dennis J Stuehr
Direct evidence for nitric oxide production by a nitric-oxide synthase-like protein from Bacillus subtilis.
The Journal of biological chemistry 2002;277(18):16167-71.
2002: Bennie H Jeng; David M Meisler; Joe G Hollyfield; Jason Connor; kulwant aulak; Dennis J Stuehr
Nitric oxide generated by corneas in corneal storage media.
Cornea 2002;21(4):410-4.
2002: Zhi-Qiang Wang; Chin-Chuan Wei; Dennis J Stuehr
A conserved tryptophan 457 modulates the kinetics and extent of N-hydroxy-L-arginine oxidation by inducible nitric-oxide synthase.
The Journal of biological chemistry 2002;277(15):12830-7.
2002: Yishi Chen; Koustubh Panda; Dennis J Stuehr
Control of nitric oxide synthase dimer assembly by a heme-NO-dependent mechanism.
Biochemistry 2002;41(14):4618-25.
2002: Masaru Miyagi; Hirokazu Sakaguchi; Ruth M Darrow; Lin Yan; Karen A West; kulwant aulak; Dennis J Stuehr; Joe G Hollyfield; Daniel T Organisciak; John W Crabb
Evidence that light modulates protein nitration in rat retina.
Molecular & cellular proteomics : MCP 2002;1(4):293-303.
2002: Axelle Renodon-Cornière; Sylvie Dijols; Céline Perollier; David Lefevre-Groboillot; Jean-Luc Boucher; Roger Attias; Marie-Agnès Sari; Dennis J Stuehr; Daniel Mansuy
N-Aryl N'-hydroxyguanidines, a new class of NO-donors after selective oxidation by nitric oxide synthases: structure-activity relationship.
Journal of medicinal chemistry 2002;45(4):944-54.
2002: Subrata Adak; Alexandrine M Bilwes; Koustubh Panda; David J Hosfield; kulwant aulak; John F McDonald; John A Tainer; Elizabeth D Getzoff; Brian R Crane; Dennis J Stuehr
Cloning, expression, and characterization of a nitric oxide synthase protein from Deinococcus radiodurans.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(1):107-12.
2002: Eric Blasko; Charles B Glaser; James J Devlin; Wei Xia; Richard I Feldman; Mark A Polokoff; Gary B Phillips; Marc Whitlow; Douglas S Auld; Kirk McMillan; Sanjay Ghosh; Dennis J Stuehr; John Parkinson
Mechanistic studies with potent and selective inducible nitric-oxide synthase dimerization inhibitors.
The Journal of biological chemistry 2002;277(1):295-302.
2002: Chin-Chuan Wei; Zhi-Qiang Wang; Dennis J Stuehr
Nitric oxide synthase: use of stopped-flow spectroscopy and rapid-quench methods in single-turnover conditions to examine formation and reactions of heme-O2 intermediate in early catalysis.
Methods in enzymology 2002;354():320-38.
2001: Jerome Santolini; Abigail L Meade; Dennis J Stuehr
Differences in three kinetic parameters underpin the unique catalytic profiles of nitric-oxide synthases I, II, and III.
The Journal of biological chemistry 2001;276(52):48887-98.
2001: M Aoyagi; Andrew S Arvai; Sanjay Ghosh; Dennis J Stuehr; John A Tainer; Elizabeth D Getzoff
Structures of tetrahydrobiopterin binding-site mutants of inducible nitric oxide synthase oxygenase dimer and implicated roles of Trp457.
Biochemistry 2001;40(43):12826-32.
2001: Zhi-Qiang Wang; Chin-Chuan Wei; Sanjay Ghosh; Abigail L Meade; Craig Hemann; Russ Hille; Dennis J Stuehr
A conserved tryptophan in nitric oxide synthase regulates heme-dioxy reduction by tetrahydrobiopterin.
Biochemistry 2001;40(43):12819-25.
2001: Manon Couture; S Adak; Dennis J Stuehr; Denis L Rousseau
Regulation of the properties of the heme-NO complexes in nitric-oxide synthase by hydrogen bonding to the proximal cysteine.
The Journal of biological chemistry 2001;276(41):38280-8.
2001: kulwant aulak; Masaru Miyagi; Lin Yan; Karen A West; D Massillon; John W Crabb; Dennis J Stuehr
Proteomic method identifies proteins nitrated in vivo during inflammatory challenge.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(21):12056-61.
2001: Sylvie Dijols; C Perollier; David Lefevre-Groboillot; Stéphanie Pethe; Roger Attias; Jean-Luc Boucher; Dennis J Stuehr; Daniel Mansuy
Oxidation of N(omega)-hydroxyarginine analogues by NO-synthase: the simple, non amino acid N-butyl N'-hydroxyguanidine is almost as efficient an NO precursor as N(omega)-hydroxyarginine.
Journal of medicinal chemistry 2001;44(20):3199-202.
2001: Koustubh Panda; Sanjay Ghosh; Dennis J Stuehr
Calmodulin activates intersubunit electron transfer in the neuronal nitric-oxide synthase dimer.
The Journal of biological chemistry 2001;276(26):23349-56.
2001: Subrata Adak; kulwant aulak; Dennis J Stuehr
Chimeras of nitric-oxide synthase types I and III establish fundamental correlates between heme reduction, heme-NO complex formation, and catalytic activity.
The Journal of biological chemistry 2001;276(26):23246-52.
2001: Ruben Zamora; Yoram Vodovotz; Louis Alarcon; Binnie Betten; Patricia A Loughran; kulwant aulak; Dennis J Stuehr; Kevin F Gibson; Timothy R Billiar
Nitric oxide from the inducible nitric oxide synthase (iNOS) increases the expression of cytochrome P450 2E1 in iNOS-null hepatocytes in the absence of inflammatory stimuli.
Archives of biochemistry and biophysics 2001;390(2):287-94.
2001: Husam M Abu-Soud; K Ichimori; H Nakazawa; Dennis J Stuehr
Regulation of inducible nitric oxide synthase by self-generated NO.
Biochemistry 2001;40(23):6876-81.
2001: Dennis J Stuehr; Sovitj Pou; Gerald M. Rosen
Oxygen reduction by nitric-oxide synthases.
The Journal of biological chemistry 2001;276(18):14533-6.
2001: Subrata Adak; Dennis J Stuehr
A proximal tryptophan in NO synthase controls activity by a novel mechanism.
Journal of inorganic biochemistry 2001;83(4):301-8.
2001: C Moali; Jean-Luc Boucher; A Renodon-Corniere; Dennis J Stuehr; Daniel Mansuy
Oxidations of N(omega)-hydroxyarginine analogues and various N-hydroxyguanidines by NO synthase II: key role of tetrahydrobiopterin in the reaction mechanism and substrate selectivity.
Chemical research in toxicology 2001;14(2):202-10.
2001: Jerome Santolini; Subrata Adak; C M Curran; Dennis J Stuehr
A kinetic simulation model that describes catalysis and regulation in nitric-oxide synthase.
The Journal of biological chemistry 2001;276(2):1233-43.
2001: Subrata Adak; Jerome Santolini; S Tikunova; Qing Wang; J D Johnson; Dennis J Stuehr
Neuronal nitric-oxide synthase mutant (Ser-1412 --> Asp) demonstrates surprising connections between heme reduction, NO complex formation, and catalysis.
The Journal of biological chemistry 2001;276(2):1244-52.
2001: Chin-Chuan Wei; Zhi-Qiang Wang; Qing Wang; Abigail L Meade; Craig Hemann; Russ Hille; Dennis J Stuehr
Rapid kinetic studies link tetrahydrobiopterin radical formation to heme-dioxy reduction and arginine hydroxylation in inducible nitric-oxide synthase.
The Journal of biological chemistry 2001;276(1):315-9.
2000: Subrata Adak; Qing Wang; Dennis J Stuehr
Arginine conversion to nitroxide by tetrahydrobiopterin-free neuronal nitric-oxide synthase. Implications for mechanism.
The Journal of biological chemistry 2000;275(43):33554-61.
2000: C Moali; M Brollo; J Custot; Marie-Agnès Sari; Jean-Luc Boucher; Dennis J Stuehr; Daniel Mansuy
Recognition of alpha-amino acids bearing various C=NOH functions by nitric oxide synthase and arginase involves very different structural determinants.
Biochemistry 2000;39(28):8208-18.
2000: Husam M Abu-Soud; K Ichimori; A Presta; Dennis J Stuehr
Electron transfer, oxygen binding, and nitric oxide feedback inhibition in endothelial nitric-oxide synthase.
The Journal of biological chemistry 2000;275(23):17349-57.
2000: Subrata Adak; Qing Wang; Dennis J Stuehr
Molecular basis for hyperactivity in tryptophan 409 mutants of neuronal NO synthase.
The Journal of biological chemistry 2000;275(23):17434-9.
2000: Brian R Crane; Andrew S Arvai; Sanjay Ghosh; Elizabeth D Getzoff; Dennis J Stuehr; John A Tainer
Structures of the N(omega)-hydroxy-L-arginine complex of inducible nitric oxide synthase oxygenase dimer with active and inactive pterins.
Biochemistry 2000;39(16):4608-21.
2000: S Boggs; L Huang; Dennis J Stuehr
Formation and reactions of the heme-dioxygen intermediate in the first and second steps of nitric oxide synthesis as studied by stopped-flow spectroscopy under single-turnover conditions.
Biochemistry 2000;39(9):2332-9.
1999: Brian R Crane; Robin J Rosenfeld; Andrew S Arvai; DK Ghosh; Sanjay Ghosh; John A Tainer; Dennis J Stuehr; Elizabeth D Getzoff
N-terminal domain swapping and metal ion binding in nitric oxide synthase dimerization.
The EMBO journal 1999;18(22):6271-81.
1999: DK Ghosh; Brian R Crane; Sanjay Ghosh; D Wolan; Ratan Gachhui; C Crooks; A Presta; John A Tainer; Elizabeth D Getzoff; Dennis J Stuehr
Inducible nitric oxide synthase: role of the N-terminal beta-hairpin hook and pterin-binding segment in dimerization and tetrahydrobiopterin interaction.
The EMBO journal 1999;18(22):6260-70.
1999: Husam M Abu-Soud; J Wang; Denis L Rousseau; Dennis J Stuehr
Stopped-flow analysis of substrate binding to neuronal nitric oxide synthase.
Biochemistry 1999;38(38):12446-51.
1999: Subrata Adak; C Crooks; Qing Wang; Brian R Crane; John A Tainer; Elizabeth D Getzoff; Dennis J Stuehr
Tryptophan 409 controls the activity of neuronal nitric-oxide synthase by regulating nitric oxide feedback inhibition.
The Journal of biological chemistry 1999;274(38):26907-11.
1999: Sanjay Ghosh; D Wolan; Subrata Adak; Brian R Crane; N S Kwon; John A Tainer; Elizabeth D Getzoff; Dennis J Stuehr
Mutational analysis of the tetrahydrobiopterin-binding site in inducible nitric-oxide synthase.
The Journal of biological chemistry 1999;274(34):24100-12.
1999: Subrata Adak; Sanjay Ghosh; Husam M Abu-Soud; Dennis J Stuehr
Role of reductase domain cluster 1 acidic residues in neuronal nitric-oxide synthase. Characterization of the FMN-FREE enzyme.
The Journal of biological chemistry 1999;274(32):22313-20.
1999: Dennis J Stuehr
Mammalian nitric oxide synthases.
Biochimica et biophysica acta 1999;1411(2-3):217-30.
1999: Axelle Renodon-Cornière; Jean-Luc Boucher; Sylvie Dijols; Dennis J Stuehr; Daniel Mansuy
Efficient formation of nitric oxide from selective oxidation of N-aryl N'-hydroxyguanidines by inducible nitric oxide synthase.
Biochemistry 1999;38(15):4663-8.
1999: L Huang; Husam M Abu-Soud; Russ Hille; Dennis J Stuehr
Nitric oxide-generated P420 nitric oxide synthase: characterization and roles for tetrahydrobiopterin and substrate in protecting against or reversing the P420 conversion.
Biochemistry 1999;38(6):1912-20.
1999: N Sennequier; D Wolan; Dennis J Stuehr
Antifungal imidazoles block assembly of inducible NO synthase into an active dimer.
The Journal of biological chemistry 1999;274(2):930-8.
1998: Sanjay Ghosh; Ratan Gachhui; C Crooks; Chuanyue Wu; M P Lisanti; Dennis J Stuehr
Interaction between caveolin-1 and the reductase domain of endothelial nitric-oxide synthase. Consequences for catalysis.
The Journal of biological chemistry 1998;273(35):22267-71.
1998: U Siddhanta; A Presta; B Fan; D Wolan; Denis L Rousseau; Dennis J Stuehr
Domain swapping in inducible nitric-oxide synthase. Electron transfer occurs between flavin and heme groups located on adjacent subunits in the dimer.
The Journal of biological chemistry 1998;273(30):18950-8.
1998: C Moali; Jean-Luc Boucher; Marie-Agnès Sari; Dennis J Stuehr; Daniel Mansuy
Substrate specificity of NO synthases: detailed comparison of L-arginine, homo-L-arginine, their N omega-hydroxy derivatives, and N omega-hydroxynor-L-arginine.
Biochemistry 1998;37(29):10453-60.
1998: A Renodon; Jean-Luc Boucher; C Wu; R Gachhui; Marie-Agnès Sari; Daniel Mansuy; Dennis J Stuehr
Formation of nitric oxide synthase-iron(II) nitrosoalkane complexes: severe restriction of access to the iron(II) site in the presence of tetrahydrobiopterin.
Biochemistry 1998;37(18):6367-74.
1998: Brian R Crane; Andrew S Arvai; DK Ghosh; Chuanyue Wu; Elizabeth D Getzoff; Dennis J Stuehr; John A Tainer
Structure of nitric oxide synthase oxygenase dimer with pterin and substrate.
Science (New York, N.Y.) 1998;279(5359):2121-6.
1998: Husam M Abu-Soud; Chuanyue Wu; DK Ghosh; Dennis J Stuehr
Stopped-flow analysis of CO and NO binding to inducible nitric oxide synthase.
Biochemistry 1998;37(11):3777-86.
1998: Ratan Gachhui; Husam M Abu-Soud; D K Ghosha; A Presta; Michael A Blazing; Bernd Mayer; Samuel E George; Dennis J Stuehr
Neuronal nitric-oxide synthase interaction with calmodulin-troponin C chimeras.
The Journal of biological chemistry 1998;273(10):5451-4.
1998: A Presta; U Siddhanta; Chuanyue Wu; N Sennequier; L Huang; Husam M Abu-Soud; Serpil C Erzurum; Dennis J Stuehr
Comparative functioning of dihydro- and tetrahydropterins in supporting electron transfer, catalysis, and subunit dimerization in inducible nitric oxide synthase.
Biochemistry 1998;37(1):298-310.
1997: B Fan; Jiaqian Wang; Dennis J Stuehr; Denis L Rousseau
NO synthase isozymes have distinct substrate binding sites.
Biochemistry 1997;36(42):12660-5.
1997: Brian R Crane; Andrew S Arvai; Ratan Gachhui; Chuanyue Wu; DK Ghosh; Elizabeth D Getzoff; Dennis J Stuehr; John A Tainer
The structure of nitric oxide synthase oxygenase domain and inhibitor complexes.
Science (New York, N.Y.) 1997;278(5337):425-31.
1997: Husam M Abu-Soud; A Presta; Bernd Mayer; Dennis J Stuehr
Analysis of neuronal NO synthase under single-turnover conditions: conversion of Nomega-hydroxyarginine to nitric oxide and citrulline.
Biochemistry 1997;36(36):10811-6.
1997: DK Ghosh; Chuanyue Wu; Eva Pitters; M Moloney; Ernst R Werner; Bernd Mayer; Dennis J Stuehr
Characterization of the inducible nitric oxide synthase oxygenase domain identifies a 49 amino acid segment required for subunit dimerization and tetrahydrobiopterin interaction.
Biochemistry 1997;36(35):10609-19.
1997: Husam M Abu-Soud; Ratan Gachhui; F M Raushel; Dennis J Stuehr
The ferrous-dioxy complex of neuronal nitric oxide synthase. Divergent effects of L-arginine and tetrahydrobiopterin on its stability.
The Journal of biological chemistry 1997;272(28):17349-53.
1997: Ratan Gachhui; DK Ghosh; Chuanyue Wu; J Parkinson; Brian R Crane; Dennis J Stuehr
Mutagenesis of acidic residues in the oxygenase domain of inducible nitric-oxide synthase identifies a glutamate involved in arginine binding.
Biochemistry 1997;36(17):5097-103.
1997: A Presta; J Liu; W C Sessa; Dennis J Stuehr
Substrate binding and calmodulin binding to endothelial nitric oxide synthase coregulate its enzymatic activity.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 1997;1(1):74-87.
1997: Dennis J Stuehr
Structure-function aspects in the nitric oxide synthases.
Annual review of pharmacology and toxicology 1997;37():339-59.
1996: Husam M Abu-Soud; Denis L Rousseau; Dennis J Stuehr
Nitric oxide binding to the heme of neuronal nitric-oxide synthase links its activity to changes in oxygen tension.
The Journal of biological chemistry 1996;271(51):32515-8.
1996: Ratan Gachhui; A Presta; D F Bentley; Husam M Abu-Soud; R McArthur; Gary W Brudvig; DK Ghosh; Dennis J Stuehr
Characterization of the reductase domain of rat neuronal nitric oxide synthase generated in the methylotrophic yeast Pichia pastoris. Calmodulin response is complete within the reductase domain itself.
The Journal of biological chemistry 1996;271(34):20594-602.
1996: C Wu; J Zhang; Husam M Abu-Soud; D K Ghosh; Dennis J Stuehr
High-level expression of mouse inducible nitric oxide synthase in Escherichia coli requires coexpression with calmodulin.
Biochemical and biophysical research communications 1996;222(2):439-44.
1996: N Sennequier; Dennis J Stuehr
Analysis of substrate-induced electronic, catalytic, and structural changes in inducible NO synthase.
Biochemistry 1996;35(18):5883-92.
1996: U Siddhanta; Chuanyue Wu; Husam M Abu-Soud; J Zhang; DK Ghosh; Dennis J Stuehr
Heme iron reduction and catalysis by a nitric oxide synthase heterodimer containing one reductase and two oxygenase domains.
The Journal of biological chemistry 1996;271(13):7309-12.
1996: DK Ghosh; Husam M Abu-Soud; Dennis J Stuehr
Domains of macrophage N(O) synthase have divergent roles in forming and stabilizing the active dimeric enzyme.
Biochemistry 1996;35(5):1444-9.
1995: Husam M Abu-Soud; J Wang; Denis L Rousseau; J M Fukuto; Louis J Ignarro; Dennis J Stuehr
Neuronal nitric oxide synthase self-inactivates by forming a ferrous-nitrosyl complex during aerobic catalysis.
The Journal of biological chemistry 1995;270(39):22997-3006.
1995: DK Ghosh; Husam M Abu-Soud; Dennis J Stuehr
Reconstitution of the second step in NO synthesis using the isolated oxygenase and reductase domains of macrophage NO synthase.
Biochemistry 1995;34(36):11316-20.
1995: Husam M Abu-Soud; M Loftus; Dennis J Stuehr
Subunit dissociation and unfolding of macrophage NO synthase: relationship between enzyme structure, prosthetic group binding, and catalytic function.
Biochemistry 1995;34(35):11167-75.
1995: FH Guo; H R De Raeve; T W Rice; Dennis J Stuehr; Frederik B J M Thunnissen; Serpil C Erzurum
Continuous nitric oxide synthesis by inducible nitric oxide synthase in normal human airway epithelium in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(17):7809-13.
1995: DK Ghosh; Dennis J Stuehr
Macrophage NO synthase: characterization of isolated oxygenase and reductase domains reveals a head-to-head subunit interaction.
Biochemistry 1995;34(3):801-7.
1995: Dennis J Stuehr; Husam M Abu-Soud; Denis L Rousseau; P L Feldman; J Wang
Control of electron transfer in neuronal nitric oxide synthase by calmodulin, substrate, substrate analogs, and nitric oxide.
Advances in pharmacology (San Diego, Calif.) 1995;34():207-13.
1994: Husam M Abu-Soud; P L Feldman; P Clark; Dennis J Stuehr
Electron transfer in the nitric-oxide synthases. Characterization of L-arginine analogs that block heme iron reduction.
The Journal of biological chemistry 1994;269(51):32318-26.
1994: Husam M Abu-Soud; L L Yoho; Dennis J Stuehr
Calmodulin controls neuronal nitric-oxide synthase by a dual mechanism. Activation of intra- and interdomain electron transfer.
The Journal of biological chemistry 1994;269(51):32047-50.
1993: Husam M Abu-Soud; Dennis J Stuehr
Nitric oxide synthases reveal a role for calmodulin in controlling electron transfer.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(22):10769-72.
1993: K J Baek; B A Thiel; S Lucas; Dennis J Stuehr
Macrophage nitric oxide synthase subunits. Purification, characterization, and role of prosthetic groups and substrate in regulating their association into a dimeric enzyme.
The Journal of biological chemistry 1993;268(28):21120-9.
1993: Jon M Fukuto; Dennis J Stuehr; P L Feldman; Michael P Bova; P Wong
Peracid oxidation of an N-hydroxyguanidine compound: a chemical model for the oxidation of N omega-hydroxyl-L-arginine by nitric oxide synthase.
Journal of medicinal chemistry 1993;36(18):2666-70.
1993: W Deng; B Thiel; Charles S Tannenbaum; Thomas Hamilton; Dennis J Stuehr
Synergistic cooperation between T cell lymphokines for induction of the nitric oxide synthase gene in murine peritoneal macrophages.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(1):322-9.
1993: P L Feldman; O W Griffith; H Hong; Dennis J Stuehr
Irreversible inactivation of macrophage and brain nitric oxide synthase by L-NG-methylarginine requires NADPH-dependent hydroxylation.
Journal of medicinal chemistry 1993;36(4):491-6.
1992: Dennis J Stuehr; M Ikeda-Saito
Spectral characterization of brain and macrophage nitric oxide synthases. Cytochrome P-450-like hemeproteins that contain a flavin semiquinone radical.
The Journal of biological chemistry 1992;267(29):20547-50.
1992: Dennis J Stuehr; O W Griffith
Mammalian nitric oxide synthases.
Advances in enzymology and related areas of molecular biology 1992;65():287-346.
1991: N S Kwon; Dennis J Stuehr; C F Nathan
Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide.
The Journal of experimental medicine 1991;174(4):761-7.
1991: Dennis J Stuehr; H J Cho; N S Kwon; M F Weise; C F Nathan
Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(17):7773-7.
1991: Dennis J Stuehr; N S Kwon; C F Nathan; O W Griffith; P L Feldman; J Wiseman
N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine.
The Journal of biological chemistry 1991;266(10):6259-63.
1991: Dennis J Stuehr; O A Fasehun; N S Kwon; Steven S Gross; J A Gonzalez; R Levi; C F Nathan
Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1991;5(1):98-103.
1990: N S Kwon; C F Nathan; C Gilker; O W Griffith; D E Matthews; Dennis J Stuehr
L-citrulline production from L-arginine by macrophage nitric oxide synthase. The ureido oxygen derives from dioxygen.
The Journal of biological chemistry 1990;265(23):13442-5.
1990: C F Nathan; Dennis J Stuehr
Does endothelium-derived nitric oxide have a role in cytokine-induced hypotension?
Journal of the National Cancer Institute 1990;82(9):726-8.
1990: Dennis J Stuehr; N S Kwon; C F Nathan
FAD and GSH participate in macrophage synthesis of nitric oxide.
Biochemical and biophysical research communications 1990;168(2):558-65.
1989: N S Kwon; C F Nathan; Dennis J Stuehr
Reduced biopterin as a cofactor in the generation of nitrogen oxides by murine macrophages.
The Journal of biological chemistry 1989;264(34):20496-501.
1989: Dennis J Stuehr; N S Kwon; Steven S Gross; B A Thiel; R Levi; C F Nathan
Synthesis of nitrogen oxides from L-arginine by macrophage cytosol: requirement for inducible and constitutive components.
Biochemical and biophysical research communications 1989;161(2):420-6.
1989: Dennis J Stuehr; C F Nathan
Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.
The Journal of experimental medicine 1989;169(5):1543-55.
1989: Dennis J Stuehr; Steven S Gross; I Sakuma; R Levi; C F Nathan
Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide.
The Journal of experimental medicine 1989;169(3):1011-20.