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Edward Sturrock

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Mario R W Ehlers; J Albert Abrie; Edward D Sturrock
C domain-selective inhibition of angiotensin-converting enzyme.
R Domingo; Edward D Sturrock; Malcolm Collins
ACE Activity and Endurance Performance during the South African Ironman Triathlons.
Patrícia Alessandra Bersanetti; Ross G Douglas; Maria A Juliano; Beatriz S Matos; Aloysius Nchinda; João Bosco Pesquero; Regiane A Sabatini; Edward D Sturrock; Adriana K Carmona
Characterization of angiotensin I-converting enzyme N-domain selectivity using positional-scanning combinatorial libraries of fluorescence resonance energy transfer peptides.

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All Publications

2013: Mario R W Ehlers; J Albert Abrie; Edward D Sturrock
C domain-selective inhibition of angiotensin-converting enzyme.
Journal of the renin-angiotensin-aldosterone system : JRAAS 2013;14(2):189-92.
2013: R Domingo; Edward D Sturrock; Malcolm Collins
ACE Activity and Endurance Performance during the South African Ironman Triathlons.
International journal of sports medicine 2013;34(5):402-8.
2012: Patrícia Alessandra Bersanetti; Ross G Douglas; Maria A Juliano; Beatriz S Matos; Aloysius Nchinda; João Bosco Pesquero; Regiane A Sabatini; Edward D Sturrock; Adriana K Carmona
Characterization of angiotensin I-converting enzyme N-domain selectivity using positional-scanning combinatorial libraries of fluorescence resonance energy transfer peptides.
Biological chemistry 2012;393(12):1547-54.
2012: Mohd Akif; Richard J Bingham; R Elwyn Isaac; Geoffrey Masuyer; Edward D Sturrock; K Ravi Acharya
Structural basis of peptide recognition by the angiotensin-1 converting enzyme homologue AnCE from Drosophila melanogaster.
The FEBS journal 2012;279(24):4525-34.
2012: Mario R W Ehlers; Kerry Gordon; Sylva L U Schwager; Edward D Sturrock
Shedding the load of hypertension: the proteolytic processing of angiotensin-converting enzyme.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 2012;102(6):461-4.
2012: Geoffrey Masuyer; Sylva L U Schwager; Edward D Sturrock; R Elwyn Isaac; K Ravi Acharya
Molecular recognition and regulation of human angiotensin-I converting enzyme (ACE) activity by natural inhibitory peptides.
Scientific reports 2012;2():717.
2012: C S Anthony; G Masuyer; Edward D Sturrock; K R Acharya
Structure based drug design of angiotensin-I converting enzyme inhibitors.
Current medicinal chemistry 2012;19(6):845-55.
2011: Riyad Domingo; Kelly Chibale; Edward D Sturrock
The significance of the C(α) substituent in the selective inhibition of matrix metalloproteinases 1 and 9.
Biological chemistry 2011;392(11):1003-10.
2011: Mohd Akif; Bhaskar J Bhuyan; R Elwyn Isaac; Geoffrey Masuyer; Govindasamy Mugesh; Sylva L U Schwager; Edward D Sturrock; K Ravi Acharya
Structural characterization of angiotensin I-converting enzyme in complex with a selenium analogue of captopril.
The FEBS journal 2011;278(19):3644-50.
2011: Mohd Akif; Sylva L U Schwager; Colin S Anthony; Bertrand Czarny; Fabrice Beau; Vincent Dive; Edward D Sturrock; K Ravi Acharya
Novel mechanism of inhibition of human angiotensin-I-converting enzyme (ACE) by a highly specific phosphinic tripeptide.
The Biochemical journal 2011;436(1):53-9.
2011: Sergei M Danilov; Kerry Gordon; Sergey Kalinin; Heinrich Lünsdorf; Emma Mendonca; Richard D Minshall; Andrew B Nesterovitch; Pavel A Petukhov; Isolda A Popova; David E Schwartz; Maricela Castellon; Zhenlong Chen; Edward D Sturrock
An angiotensin I-converting enzyme mutation (Y465D) causes a dramatic increase in blood ACE via accelerated ACE shedding.
PloS one 2011;6(10):e25952.
2010: Colin S Anthony; Hazel R Corradi; Sylva L U Schwager; Pierre Redelinghuys; Dimitris Georgiadis; Vincent Dive; K Ravi Acharya; Edward D Sturrock
The N domain of human angiotensin-I-converting enzyme: the role of N-glycosylation and the crystal structure in complex with an N domain-specific phosphinic inhibitor, RXP407.
The Journal of biological chemistry 2010;285(46):35685-93.
2010: Maria C C de Andrade; Regina Affonso; Fernanda B Fernandes; Andréia C Febba; Ismael D C G da Silva; RC Stella; Odair Marson; Guita N Jubilut; Izaura Y Hirata; Adriana K Carmona; Hazel Corradi; K Ravi Acharya; Edward D Sturrock; Dulce Elena Casarini
Spectroscopic and structural analysis of somatic and N-domain angiotensin I-converting enzyme isoforms from mesangial cells from Wistar and spontaneously hypertensive rats.
International journal of biological macromolecules 2010;47(2):238-43.
2010: Mohd Akif; Ioanna Ntai; Edward D Sturrock; R Elwyn Isaac; Brian O Bachmann; K Ravi Acharya
Crystal structure of a phosphonotripeptide K-26 in complex with angiotensin converting enzyme homologue (AnCE) from Drosophila melanogaster.
Biochemical and biophysical research communications 2010;398(3):532-6.
2010: Mohd Akif; Dimitris Georgiadis; Aman Mahajan; Vincent Dive; Edward D Sturrock; R Elwyn Isaac; K Ravi Acharya
High-resolution crystal structures of Drosophila melanogaster angiotensin-converting enzyme in complex with novel inhibitors and antihypertensive drugs.
Journal of molecular biology 2010;400(3):502-17.
2010: Jean M Watermeyer; Wendy L Kröger; Hester G O'Neill; B Trevor Sewell; Edward D Sturrock
Characterization of domain-selective inhibitor binding in angiotensin-converting enzyme using a novel derivative of lisinopril.
The Biochemical journal 2010;428(1):67-74.
2010: Nikolaos Dimitropoulos; Athanasios Papakyriakou; Georgios A Dalkas; Edward D Sturrock; Georgios A A. Spyroulias
A computational approach to the study of the binding mode of dual ACE/NEP inhibitors.
Journal of chemical information and modeling 2010;50(3):388-96.
2010: Kerry Gordon; I V Balyasnikova; A B Nesterovitch; D E Schwartz; Edward D Sturrock; Sergei M Danilov
Fine epitope mapping of monoclonal antibodies 9B9 and 3G8 to the N domain of angiotensin-converting enzyme (CD143) defines a region involved in regulating angiotensin-converting enzyme dimerization and shedding.
Tissue antigens 2010;75(2):136-50.
2009: Wendy L Kröger; Ross G Douglas; Hester G O'Neill; Vincent Dive; Edward D Sturrock
Investigating the domain specificity of phosphinic inhibitors RXPA380 and RXP407 in angiotensin-converting enzyme.
Biochemistry 2009;48(35):8405-12.
2009: Carlos Eduardo L Cunha; Helena de Fátima Magliarelli; Thaysa Paschoalin; Aloysius T Nchinda; Jackson C Lima; Maria A Juliano; Paiva Paulo; Edward D Sturrock; Luiz Travassos; Adriana K Carmona
Catalytic properties of recombinant dipeptidyl carboxypeptidase from Escherichia coli: a comparative study with angiotensin I-converting enzyme.
Biological chemistry 2009;390(9):931-40.
2008: Irina V Balyasnikova; Roman Metzger; Folker E Franke; N Conrad; H Towbin; David E Schwartz; Edward D Sturrock; Sergei M Danilov
Epitope mapping of mAbs to denatured human testicular ACE (CD143).
Tissue antigens 2008;72(4):354-68.
2008: Hester G O'Neill; Pierre Redelinghuys; Sylva L U Schwager; Edward D Sturrock
The role of glycosylation and domain interactions in the thermal stability of human angiotensin-converting enzyme.
Biological chemistry 2008;389(9):1153-61.
2008: Irina A Naperova; Irina V Balyasnikova; David E Schwartz; Jean Watermeyer; Edward D Sturrock; Olga A Kost; Sergei M Danilov
Mapping of conformational mAb epitopes to the C domain of human angiotensin I-converting enzyme.
Journal of proteome research 2008;7(8):3396-411.
2008: Jean M Watermeyer; Wendy L Kröger; Hester G O'Neill; B Trevor Sewell; Edward D Sturrock
Probing the basis of domain-dependent inhibition using novel ketone inhibitors of Angiotensin-converting enzyme.
Biochemistry 2008;47(22):5942-50.
2007: Dawn Webber; Allen L Rodgers; Edward D Sturrock
Glycosylation of prothrombin fragment 1 governs calcium oxalate crystal nucleation and aggregation, but not crystal growth.
Urological research 2007;35(6):277-85.
2007: Guillaume Rivière; Annie Michaud; Hazel R Corradi; Edward D Sturrock; K Ravi Acharya; Virginie Cogez; Jean-Pierre Bohin; Didier Vieau; Pierre Corvol
Characterization of the first angiotensin-converting like enzyme in bacteria: Ancestor ACE is already active.
Gene 2007;399(1):81-90.
2007: Sergei M Danilov; Jean M Watermeyer; Irina V Balyasnikova; Kerry Gordon; Elena V Kugaevskaya; Yulia E Elisseeva; Ronald F Albrecht; Edward D Sturrock
Fine epitope mapping of monoclonal antibody 5F1 reveals anticatalytic activity toward the N domain of human angiotensin-converting enzyme.
Biochemistry 2007;46(31):9019-31.
2007: Hazel R Corradi; Itai Chitapi; B Trevor Sewell; Dimitris Georgiadis; Vincent Dive; Edward D Sturrock; K Ravi Acharya
The structure of testis angiotensin-converting enzyme in complex with the C domain-specific inhibitor RXPA380.
Biochemistry 2007;46(18):5473-8.
2006: Hazel R Corradi; Anne V Corrigall; Ester Boix; C Gopi Mohan; Edward D Sturrock; Peter N Meissner; K Ravi Acharya
Crystal structure of protoporphyrinogen oxidase from Myxococcus xanthus and its complex with the inhibitor acifluorfen.
The Journal of biological chemistry 2006;281(50):38625-33.
2006: Allen L Rodgers; Priscilla D Mensah; Sylva L U Schwager; Edward D Sturrock
Inhibition of calcium oxalate crystallization by commercial human serum albumin and human urinary albumin isolated from two different race groups: evidence for possible molecular differences.
Urological research 2006;34(6):373-80.
2006: Jean M Watermeyer; B Trevor Sewell; Sylva L U Schwager; Ramanathan Natesh; Hazel R Corradi; K Ravi Acharya; Edward D Sturrock
Structure of testis ACE glycosylation mutants and evidence for conserved domain movement.
Biochemistry 2006;45(42):12654-63.
2006: Aloysius T Nchinda; Kelly Chibale; Pierre Redelinghuys; Edward D Sturrock
Synthesis of novel keto-ACE analogues as domain-selective angiotensin I-converting enzyme inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(17):4612-5.
2006: Aloysius T Nchinda; Kelly Chibale; Pierre Redelinghuys; Edward D Sturrock
Synthesis and molecular modeling of a lisinopril-tryptophan analogue inhibitor of angiotensin I-converting enzyme.
Bioorganic & medicinal chemistry letters 2006;16(17):4616-9.
2006: Zenda L Woodman; Sylva L U Schwager; Pierre Redelinghuys; Anthony Chubb; Elizabeth van der Merwe; Mario R W Ehlers; Edward D Sturrock
Homologous substitution of ACE C-domain regions with N-domain sequences: effect on processing, shedding, and catalytic properties.
Biological chemistry 2006;387(8):1043-51.
2006: Dawn Webber; Catherine M Radcliffe; Louise Royle; Gemma Tobiasen; Anthony H Merry; Allen L Rodgers; Edward D Sturrock; Mark R Wormald; David Harvey; Raymond A Dwek; Pauline M Rudd
Sialylation of urinary prothrombin fragment 1 is implicated as a contributory factor in the risk of calcium oxalate kidney stone formation.
The FEBS journal 2006;273(13):3024-37.
2006: Shirley L Farias; Regiane A Sabatini; Tatiana C Sampaio; Izaura Y Hirata; Maria Helena S Cezari; Maria A Juliano; Edward D Sturrock; Adriana K Carmona; Luiz Juliano
Angiotensin I-converting enzyme inhibitor peptides derived from the endostatin-containing NC1 fragment of human collagen XVIII.
Biological chemistry 2006;387(5):611-6.
2006: Pierre Redelinghuys; Aloysius T Nchinda; Kelly Chibale; Edward D Sturrock
Novel ketomethylene inhibitors of angiotensin I-converting enzyme (ACE): inhibition and molecular modelling.
Biological chemistry 2006;387(4):461-6.
2006: Hazel R Corradi; Sylva L U Schwager; Aloysius T Nchinda; Edward D Sturrock; K Ravi Acharya
Crystal structure of the N domain of human somatic angiotensin I-converting enzyme provides a structural basis for domain-specific inhibitor design.
Journal of molecular biology 2006;357(3):964-74.
2006: Adriana K Carmona; Sylva L U Schwager; Maria A Juliano; Luiz Juliano; Edward D Sturrock
A continuous fluorescence resonance energy transfer angiotensin I-converting enzyme assay.
Nature protocols 2006;1(4):1971-6.
2006: Sylva L U Schwager; Adriana K Carmona; Edward D Sturrock
A high-throughput fluorimetric assay for angiotensin I-converting enzyme.
Nature protocols 2006;1(4):1961-4.
2005: Neuza A Gomes Pereira; Maria A Juliano; Adriana K Carmona; Edward D Sturrock; Girish J Kotwal
Cloning and expression of a functionally active truncated N-glycosylated KSHV ORF4/KCP/kaposica in the methylotrophic yeast Pichia pastoris.
Annals of the New York Academy of Sciences 2005;1056():388-404.
2005: Pierre Redelinghuys; Aloysius T Nchinda; Edward D Sturrock
Development of domain-selective angiotensin I-converting enzyme inhibitors.
Annals of the New York Academy of Sciences 2005;1056():160-75.
2005: Zenda L Woodman; Sylva L U Schwager; Pierre Redelinghuys; Adriana K Carmona; Mario R W Ehlers; Edward D Sturrock
The N domain of somatic angiotensin-converting enzyme negatively regulates ectodomain shedding and catalytic activity.
The Biochemical journal 2005;389(Pt 3):739-44.
2005: Irina V Balyasnikova; Zenda L Woodman; Ronald F Albrecht; Ramanathan Natesh; K Ravi Acharya; Edward D Sturrock; Sergei M Danilov
Localization of an N-domain region of angiotensin-converting enzyme involved in the regulation of ectodomain shedding using monoclonal antibodies.
Journal of proteome research 2005;4(2):258-67.
2005: Irina V Balyasnikova; Zhu-Li Sun; Folker E Franke; Yuliya V Berestetskaya; Anthony Chubb; Ronald F Albrecht; Edward D Sturrock; Sergei M Danilov
Monoclonal antibodies 1B3 and 5C8 as probes for monitoring the integrity of the C-terminal end of soluble angiotensin-converting enzyme.
Hybridoma (2005) 2005;24(1):14-26.
2004: Patrícia Alessandra Bersanetti; Maria Claudina C Andrade; Dulce Elena Casarini; Maria A Juliano; Aloysius T Nchinda; Edward D Sturrock; Luiz Juliano; Adriana K Carmona
Positional-scanning combinatorial libraries of fluorescence resonance energy transfer peptides for defining substrate specificity of the angiotensin I-converting enzyme and development of selective C-domain substrates.
Biochemistry 2004;43(50):15729-36.
2004: Edward D Sturrock; Ramanathan Natesh; Jason M van Rooyen; K Ravi Acharya
Structure of angiotensin I-converting enzyme.
Cellular and molecular life sciences : CMLS 2004;61(21):2677-86.
2004: Ramanathan Natesh; Sylva L U Schwager; Hazel R Evans; Edward D Sturrock; K Ravi Acharya
Structural details on the binding of antihypertensive drugs captopril and enalaprilat to human testicular angiotensin I-converting enzyme.
Biochemistry 2004;43(27):8718-24.
2004: Tobias M J Allinson; Edward T Parkin; Thomas P Condon; Sylva L U Schwager; Edward D Sturrock; Anthony J Turner; Nigel M Hooper
The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein.
European journal of biochemistry / FEBS 2004;271(12):2539-47.
2004: Anthony Chubb; Sylva L U Schwager; Elizabeth van der Merwe; Mario R W Ehlers; Edward D Sturrock
Deletion of the cytoplasmic domain increases basal shedding of angiotensin-converting enzyme.
Biochemical and biophysical research communications 2004;314(4):971-5.
2004: Michael J Begg; Edward D Sturrock; Deneys R van der Westhuyzen
Soluble LDL-R are formed by cell surface cleavage in response to phorbol esters.
European journal of biochemistry / FEBS 2004;271(3):524-33.
2003: Jodie L Guy; Richard M Jackson; K Ravi Acharya; Edward D Sturrock; Nigel M Hooper; Anthony J Turner
Angiotensin-converting enzyme-2 (ACE2): comparative modeling of the active site, specificity requirements, and chloride dependence.
Biochemistry 2003;42(45):13185-92.
2003: K Ravi Acharya; Edward D Sturrock; James F Riordan; Mario R W Ehlers
Ace revisited: a new target for structure-based drug design.
Nature reviews. Drug discovery 2003;2(11):891-902.
2003: Kerry Gordon; Pierre Redelinghuys; Sylva L U Schwager; Mario R W Ehlers; Anastassios C Papageorgiou; Ramanathan Natesh; K Ravi Acharya; Edward D Sturrock
Deglycosylation, processing and crystallization of human testis angiotensin-converting enzyme.
The Biochemical journal 2003;371(Pt 2):437-42.
2003: Ramanathan Natesh; Sylva L U Schwager; Edward D Sturrock; K Ravi Acharya
Crystal structure of the human angiotensin-converting enzyme-lisinopril complex.
Nature 2003;421(6922):551-4.
2002: Anthony Chubb; Sylva L U Schwager; Zenda L Woodman; Mario R W Ehlers; Edward D Sturrock
Defining the boundaries of the testis angiotensin I-converting enzyme ectodomain.
Biochemical and biophysical research communications 2002;297(5):1225-30.
2002: Dawn Webber; Allen L Rodgers; Edward D Sturrock
Synergism between urinary prothrombin fragment 1 and urine: a comparison of inhibitory activities in stone-prone and stone-free population groups.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2002;40(9):930-6.
2001: Sylva L U Schwager; Anthony Chubb; Zenda L Woodman; L Yan; R Mentele; Mario R W Ehlers; Edward D Sturrock
Cleavage of disulfide-bridged stalk domains during shedding of angiotensin-converting enzyme occurs at multiple juxtamembrane sites.
Biochemistry 2001;40(51):15624-30.
2001: Susan Pang; Anthony Chubb; Sylva L U Schwager; Mario R W Ehlers; Edward D Sturrock; Nigel M Hooper
Roles of the juxtamembrane and extracellular domains of angiotensin-converting enzyme in ectodomain shedding.
The Biochemical journal 2001;358(Pt 1):185-92.
2001: Marwan Alfalah; Edward T Parkin; Ralf Jacob; Edward D Sturrock; R Mentele; Anthony J Turner; Nigel M Hooper; Hassan Y Naim
A point mutation in the juxtamembrane stalk of human angiotensin I-converting enzyme invokes the action of a distinct secretase.
The Journal of biological chemistry 2001;276(24):21105-9.
2001: D Durrbaum; Allen L Rodgers; Edward D Sturrock
A study of crystal matrix extract and urinary prothrombin fragment 1 from a stone-prone and stone-free population.
Urological research 2001;29(2):83-8.
2000: Zenda L Woodman; S Y Oppong; S Cook; Nigel M Hooper; Sylva L U Schwager; Wolf F Brandt; Mario R W Ehlers; Edward D Sturrock
Shedding of somatic angiotensin-converting enzyme (ACE) is inefficient compared with testis ACE despite cleavage at identical stalk sites.
The Biochemical journal 2000;347 Pt 3():711-8.
1999: Sylva L U Schwager; Anthony Chubb; RR Scholle; Wolf F Brandt; R Mentele; James F Riordan; Edward D Sturrock; Mario R W Ehlers
Modulation of juxtamembrane cleavage ("shedding") of angiotensin-converting enzyme by stalk glycosylation: evidence for an alternative shedding protease.
Biochemistry 1999;38(32):10388-97.
1998: Sylva L U Schwager; Anthony Chubb; RR Scholle; Wolf F Brandt; C Eckerskorn; Edward D Sturrock; Mario R W Ehlers
Phorbol ester-induced juxtamembrane cleavage of angiotensin-converting enzyme is not inhibited by a stalk containing intrachain disulfides.
Biochemistry 1998;37(44):15449-56.
1997: Edward D Sturrock; Sergei M Danilov; James F Riordan
Limited proteolysis of human kidney angiotensin-converting enzyme and generation of catalytically active N- and C-terminal domains.
Biochemical and biophysical research communications 1997;236(1):16-9.
1997: X C Yu; Edward D Sturrock; Z Wu; K Biemann; Mario R W Ehlers; James F Riordan
Identification of N-linked glycosylation sites in human testis angiotensin-converting enzyme and expression of an active deglycosylated form.
The Journal of biological chemistry 1997;272(6):3511-9.
1996: Edward D Sturrock; X C Yu; Z Wu; K Biemann; James F Riordan
Assignment of free and disulfide-bonded cysteine residues in testis angiotensin-converting enzyme: functional implications.
Biochemistry 1996;35(29):9560-6.
1991: Dennis L Maeder; Edward D Sturrock; Ralph Kirsch
Subcellular distribution of asialoglycoprotein receptor in liver regeneration.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 1991;80(4):195-7.
1989: Edward D Sturrock; Peter N Meissner; Dennis L Maeder; Ralph Kirsch
Uroporphyrinogen decarboxylase and protoporphyrinogen oxidase in dual porphyria.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 1989;76(8):405-8.
1987: Peter N Meissner; D M Meissner; Edward D Sturrock; B Davidson; Ralph Kirsch
Porphyria--the UCT experience.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 1987;72(11):755-61.