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Babu Subramanyam

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Imadul Islam; Greg Brown; Judi Bryant; Paul Hrvatin; Monica J Kochanny; Gary B Phillips; Shendong Yuan; Marc Adler; Marc Whitlow; Dao Lentz; Mark A Polokoff; James Wu; Jun Shen; Janette Walters; Elena Ho; Babu Subramanyam; Daguang Zhu; Richard I Feldman; Damian O Arnaiz
Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: optimization of BX-517.
Imadul Islam; Judi Bryant; Yuo-Ling Chou; Monica J Kochanny; Wheeseong Lee; Gary B Phillips; Hongyi Yu; Marc Adler; Marc Whitlow; Elena Ho; Dao Lentz; Mark A Polokoff; Babu Subramanyam; James M Wu; Daguang Zhu; Richard I Feldman; Damian O Arnaiz
Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: design, synthesis and biological activity.
Yi-Xin Wang; Jon Vincelette; Valdeci da Cunha; Baby Martin-McNulty; Cornell Mallari; Richard M Fitch; Serene Alexander; Imadul Islam; Brad Buckman; Shendong Yuan; Joseph M Post; Babu Subramanyam; Ronald Vergona; Mark E Sullivan; William P Dole; John Morser; Judi Bryant
A novel P2Y(12) adenosine diphosphate receptor antagonist that inhibits platelet aggregation and thrombus formation in rat and dog models.

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All Publications

2007: Imadul Islam; Greg Brown; Judi Bryant; Paul Hrvatin; Monica J Kochanny; Gary B Phillips; Shendong Yuan; Marc Adler; Marc Whitlow; Dao Lentz; Mark A Polokoff; James Wu; Jun Shen; Janette Walters; Elena Ho; Babu Subramanyam; Daguang Zhu; Richard I Feldman; Damian O Arnaiz
Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: optimization of BX-517.
Bioorganic & medicinal chemistry letters 2007;17(14):3819-25.
2007: Imadul Islam; Judi Bryant; Yuo-Ling Chou; Monica J Kochanny; Wheeseong Lee; Gary B Phillips; Hongyi Yu; Marc Adler; Marc Whitlow; Elena Ho; Dao Lentz; Mark A Polokoff; Babu Subramanyam; James M Wu; Daguang Zhu; Richard I Feldman; Damian O Arnaiz
Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: design, synthesis and biological activity.
Bioorganic & medicinal chemistry letters 2007;17(14):3814-8.
2007: Yi-Xin Wang; Jon Vincelette; Valdeci da Cunha; Baby Martin-McNulty; Cornell Mallari; Richard M Fitch; Serene Alexander; Imadul Islam; Brad Buckman; Shendong Yuan; Joseph M Post; Babu Subramanyam; Ronald Vergona; Mark E Sullivan; William P Dole; John Morser; Judi Bryant
A novel P2Y(12) adenosine diphosphate receptor antagonist that inhibits platelet aggregation and thrombus formation in rat and dog models.
Thrombosis and haemostasis 2007;97(5):847-55.
2007: Shou-Fu Lu; Binglong Chen; David D Davey; Laura Dunning; Stefan Jaroch; Karen May; James Onuffer; Gary Phillips; Babu Subramanyam; Jih-Lie Tseng; Robert G Wei; Ming Wei; Bin Ye
CCR5 receptor antagonists: discovery and SAR of novel 4-hydroxypiperidine derivatives.
Bioorganic & medicinal chemistry letters 2007;17(7):1883-7.
2007: David D Davey; Marc Adler; Damian O Arnaiz; Keith Eagen; Shawn Erickson; William J Guilford; Margaret Kenrick; Michael M Morrissey; Mike Ohlmeyer; Gonghua Pan; Vidyadhar M Paradkar; John Parkinson; Mark A Polokoff; Kurt Saionz; Cecile Santos; Babu Subramanyam; Ronald Vergona; Robert G Wei; Marc Whitlow; Bin Ye; Zuchun Spring Zhao; James J Devlin; Gary Phillips
Design, synthesis, and activity of 2-imidazol-1-ylpyrimidine derived inducible nitric oxide synthase dimerization inhibitors.
Journal of medicinal chemistry 2007;50(6):1146-57.
2007: Monica J Kochanny; Marc Adler; Janice Ewing; Brian D Griedel; Elena Ho; Rushad Karanjawala; Wheeseong Lee; Dao Lentz; Amy M Liang; Michael M Morrissey; Gary B Phillips; Joseph Post; Karna L Sacchi; Steven T Sakata; Babu Subramanyam; Ronald Vergona; Janette Walters; Kathy A White; Marc Whitlow; Bin Ye; Zuchun Zhao; Kenneth J Shaw
Substituted thiophene-anthranilamides as potent inhibitors of human factor Xa.
Bioorganic & medicinal chemistry 2007;15(5):2127-46.
2007: Yi-Xin Wang; Lei Zhao; Mariko Nagashima; Jon Vincelette; Drew Sukovich; Weiwei Li; Babu Subramanyam; Shendong Yuan; Kumar Emayan; Imadul Islam; Paul Hrvatin; Judi Bryant; David R Light; Ronald Vergona; John Morser; Brad Buckman
A novel inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) - part I: pharmacological characterization.
Thrombosis and haemostasis 2007;97(1):45-53.
2005: Deborah A Zajchowski; Sandra L Biroc; Hsaio-Lai Liu; Steven K Chesney; Jens Hoffmann; John G Bauman; Thomas Kirkland; Babu Subramanyam; Jun Shen; Elena Ho; Jih-Lie Tseng; Harald Dinter
Anti-tumor efficacy of the nucleoside analog 1-(2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranosyl) cytosine (4'-thio-FAC) in human pancreatic and ovarian tumor xenograft models.
International journal of cancer. Journal international du cancer 2005;114(6):1002-9.
2005: Yi-Xin Wang; Baby Martin-McNulty; Valdeci da Cunha; Jon Vincelette; Xiangru Lu; Qingping Feng; Meredith Halks-Miller; Mithra Mahmoudi; Miriam Schroeder; Babu Subramanyam; Jih-Lie Tseng; Gary D Deng; Sabine Schirm; Anthony Johns; Katalin Kauser; William P Dole; David R Light
Fasudil, a Rho-kinase inhibitor, attenuates angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice by inhibiting apoptosis and proteolysis.
Circulation 2005;111(17):2219-26.
2005: Stewart Leung; April Holbrook; Beverly King; Hong-Tao Lu; Vincent Evans; Neil Miyamoto; Cornell Mallari; Susan Harvey; David D Davey; Elena Ho; Wei-Wei Li; John Parkinson; Richard Horuk; Stefan Jaroch; Markus Berger; Werner Skuballa; Christopher West; Rebecca Pulk; Gary Phillips; Judi Bryant; Babu Subramanyam; Caralee Schaefer; Hugh Salamon; Eric Lyons; Daniela Schilling; Henrik Seidel; Joern Kraetzschmar; Michael Snider; Daniel Perez
Differential inhibition of inducible T cell cytokine secretion by potent iron chelators.
Journal of biomolecular screening 2005;10(2):157-67.
2004: Ying Cheng; Elena Ho; Babu Subramanyam; Jih-Lie Tseng
Measurements of drug-protein binding by using immobilized human serum albumin liquid chromatography-mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2004;809(1):67-73.
2004: Gerard Bannenberg; Rose-Laure Moussignac; Karsten Gronert; Pallavi R Devchand; Birgitta A Schmidt; William J Guilford; John G Bauman; Babu Subramanyam; H Daniel Perez; John Parkinson; Charles N Serhan
Lipoxins and novel 15-epi-lipoxin analogs display potent anti-inflammatory actions after oral administration.
British journal of pharmacology 2004;143(1):43-52.
2004: William J Guilford; John G Bauman; Werner Skuballa; Shawn Bauer; Guo Ping Wei; David D Davey; Caralee Schaefer; Cornell Mallari; Jennifer Terkelsen; Jih-Lie Tseng; Jun Shen; Babu Subramanyam; Arndt Schottelius; John Parkinson
Novel 3-oxa lipoxin A4 analogues with enhanced chemical and metabolic stability have anti-inflammatory activity in vivo.
Journal of medicinal chemistry 2004;47(8):2157-65.
2002: Gary Phillips; William J Guilford; Brad Buckman; David D Davey; Keith Eagen; Sunil Koovakkat; Amy Liang; Margaret A McCarrick; Raju Mohan; Howard P Ng; Michael Pinkerton; Babu Subramanyam; Elena Ho; Lan Trinh; Marc Whitlow; Shung Wu; Wei Xu; Michael M Morrissey
Design, synthesis, and activity of a novel series of factor Xa inhibitors: optimization of arylamidine groups.
Journal of medicinal chemistry 2002;45(12):2484-93.
2002: Howard P Ng; Brad Buckman; Keith Eagen; William J Guilford; Monica J Kochanny; Raju Mohan; Kenneth J Shaw; Shung C Wu; Dao Lentz; Amy Liang; Lan Trinh; Elena Ho; David Smith; Babu Subramanyam; Ronald Vergona; Janette Walters; Kathy A White; Mark E Sullivan; Michael M Morrissey; Gary B Phillips
Design, synthesis, and biological activity of novel factor Xa inhibitors: 4-aryloxy substituents of 2,6-diphenoxypyridines.
Bioorganic & medicinal chemistry 2002;10(3):657-66.
2000: Meina Liang; Cornell Mallari; Mary Rosser; Howard P Ng; K May; S Monahan; John G Bauman; Imadul Islam; Ameen Ghannam; Brad Buckman; K Shaw; Guo-Ping Wei; Wei Xu; Z Zhao; E Ho; J Shen; H Oanh; Babu Subramanyam; Ronald Vergona; D Taub; Laura Dunning; S Harvey; RM Snider; Joseph Hesselgesser; Michael M Morrissey; H Daniel Perez
Identification and characterization of a potent, selective, and orally active antagonist of the CC chemokine receptor-1.
The Journal of biological chemistry 2000;275(25):19000-8.
1998: Gary B Phillips; Brad Buckman; David D Davey; Keith Eagen; William J Guilford; Josephine W Hinchman; Elena Ho; Sunil Koovakkat; Amy Liang; David R Light; Raju Mohan; Howard P Ng; Joseph M Post; Kenneth J Shaw; D Smith; Babu Subramanyam; Mark E Sullivan; Lan Trinh; Ronald Vergona; Janette Walters; K White; Marc Whitlow; Shung Wu; Wei Xu; Michael M Morrissey
Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3, 5-difluoro-6-[3-(4, 5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylgl y cine (ZK-807834): a potent, selective, and orally active inhibitor of the blood coagulation enzyme factor Xa.
Journal of medicinal chemistry 1998;41(19):3557-62.