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Toshio Suda

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Yoshiko Matsumoto Ikushima; Shuh Narumiya; Fumio Arai; Tomoyuki Furuyashiki; Kentaro Hosokawa; Keiyo Takubo; Hirofumi Toyama; Toshio Suda
Prostaglandin E(2) regulates murine hematopoietic stem/progenitor cells directly via EP4 receptor and indirectly through mesenchymal progenitor cells.
Go Nagamatsu; Mototsugu Oya; Shigeru Saito; Hideo Akiyama; Hiroaki Honda; Katsuhisa Horimoto; Taisuke Kinoshita; Takeo Kosaka; Tetsuo Sudo; Keiyo Takubo; Toshio Suda
Induction of pluripotent stem cells from primordial germ cells by single reprogramming factors.
Ayako Nakamura-Ishizu; Toshio Suda
Hematopoietic stem cell niche: an interplay among a repertoire of multiple functional niches.

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2013: Yoshiko Matsumoto Ikushima; Shuh Narumiya; Fumio Arai; Tomoyuki Furuyashiki; Kentaro Hosokawa; Keiyo Takubo; Hirofumi Toyama; Toshio Suda
Prostaglandin E(2) regulates murine hematopoietic stem/progenitor cells directly via EP4 receptor and indirectly through mesenchymal progenitor cells.
Blood 2013;121(11):1995-2007.
2013: Go Nagamatsu; Mototsugu Oya; Shigeru Saito; Hideo Akiyama; Hiroaki Honda; Katsuhisa Horimoto; Taisuke Kinoshita; Takeo Kosaka; Tetsuo Sudo; Keiyo Takubo; Toshio Suda
Induction of pluripotent stem cells from primordial germ cells by single reprogramming factors.
Stem cells (Dayton, Ohio) 2013;31(3):479-87.
2013: Ayako Nakamura-Ishizu; Toshio Suda
Hematopoietic stem cell niche: an interplay among a repertoire of multiple functional niches.
Biochimica et biophysica acta 2013;1830(2):2404-9.
2013: Yoshiko Matsumoto Ikushima; Yoshiaki Kubota; Yuka Nakamura; Fumio Arai; Masanori Hirashima; Kentaro Hosokawa; Hirofumi Toyama; Toshio Suda
Enhanced Angpt1/Tie2 signaling affects the differentiation and long-term repopulation ability of hematopoietic stem cells.
Biochemical and biophysical research communications 2013;430(1):20-5.
2013: Keiyo Takubo; Makoto Suematsu; Nobuhito Goda; Atsushi Hirao; Eiji Ikeda; Randall S Johnson; Chiharu I Kobayashi; Hiroshi Kobayashi; Go Nagamatsu; Ayako Nakamura-Ishizu; Yasmeen Rahimi; Tomoyoshi Soga; Toshio Suda
Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells.
Cell stem cell 2013;12(1):49-61.
2013: Yumiko Matsubara; Mitsuru Murata; Yukako Ono; Toshio Suda; Hidenori Suzuki; Fumio Arai; Yasuo Ikeda
OP9 bone marrow stroma cells differentiate into megakaryocytes and platelets.
PloS one 2013;8(3):e58123.
2012: Hirofumi Toyama; Fumio Arai; Kentaro Hosokawa; Yoshiko Matsumoto Ikushima; Toshio Suda
N-cadherin+ HSCs in fetal liver exhibit higher long-term bone marrow reconstitution activity than N-cadherin- HSCs.
Biochemical and biophysical research communications 2012;428(3):354-9.
2012: Toshio Suda; Toshio Kitamura
Passing a baton to the next generation.
International journal of hematology 2012;96(5):529-30.
2012: Go Nagamatsu; Mototsugu Oya; Shigeru Saito; Katsuhisa Horimoto; Taisuke Kinoshita; Takeo Kosaka; Keiyo Takubo; Toshio Suda
Optimal ratio of transcription factors for somatic cell reprogramming.
The Journal of biological chemistry 2012;287(43):36273-82.
2012: Hideo Ema; Toshio Suda
Two anatomically distinct niches regulate stem cell activity.
Blood 2012;120(11):2174-81.
2012: Fumio Arai; Kentaro Hosokawa; Yoshiko Matsumoto; Hirofumi Toyama; Toshio Suda
Role of N-cadherin in the regulation of hematopoietic stem cells in the bone marrow niche.
Annals of the New York Academy of Sciences 2012;1266():72-7.
2012: Ayako Nakamura-Ishizu; Keisuke Okabe; Yuji Okuno; Yoshiki Omatsu; Toshio Suda; Toshimitsu Uede; Junko Morimoto; Takashi Nagasawa; Yoshiaki Kubota
Extracellular matrix protein tenascin-C is required in the bone marrow microenvironment primed for hematopoietic regeneration.
Blood 2012;119(23):5429-37.
2012: Go Nagamatsu; Mototsugu Oya; Shigeru Saito; Hideo Akiyama; Katsuhisa Horimoto; Takeo Kosaka; Tetsuo Sudo; Keiyo Takubo; Toshio Suda
Tracing the conversion process from primordial germ cells to pluripotent stem cells in mice.
Biology of reproduction 2012;86(6):182.
2012: Keiyo Takubo; Toshio Suda
Roles of the hypoxia response system in hematopoietic and leukemic stem cells.
International journal of hematology 2012;95(5):478-83.
2012: Ayako Nakamura-Ishizu; Hideyuki Okano; Yuji Okuno; Yoko Ozawa; Toshio Suda; Kazuo Tsubota; Nobuhito Goda; Kazuo Kishi; Toshihide Kurihara; Yoshiaki Kubota
The formation of an angiogenic astrocyte template is regulated by the neuroretina in a HIF-1-dependent manner.
Developmental biology 2012;363(1):106-14.
2012: Ai Ikejiri; Nobuhito Goda; Yutaka Kurebayashi; Shigenori Nagai; Mayuko Osada-Oka; Toshio Suda; Keiyo Takubo; Shigeo Koyasu
Dynamic regulation of Th17 differentiation by oxygen concentrations.
International immunology 2012;24(3):137-46.
2012: Chiharu I Kobayashi; Toshio Suda
Regulation of reactive oxygen species in stem cells and cancer stem cells.
Journal of cellular physiology 2012;227(2):421-30.
2012: Giichi Takaesu; Keiyo Takubo; Akihiko Yoshimura; Toshio Suda; Gregg A Dean; Paul R Hess; Maiko Inagaki; Kunihiro Matsumoto; Yuji Mishina; Jun Ninomiya-Tsuji
TAK1 (MAP3K7) signaling regulates hematopoietic stem cells through TNF-dependent and -independent mechanisms.
PloS one 2012;7(11):e51073.
2012: Hirono Iriuchishima; Masahiro Kizaki; Yoshitaka Miyakawa; Kana Miyamoto; Takeshi Miyamoto; Yoshiteru Miyauchi; Ayako Nakamura-Ishizu; Yoshihisa Nojima; Nobuyuki Fujita; Eiji Ikeda; Keiyo Takubo; Toshio Suda
Neovascular niche for human myeloma cells in immunodeficient mouse bone.
PloS one 2012;7(2):e30557.
2011: Kana Miyamoto; Kazuhiro Chiba; Wu Hao; Kazuaki Hashimoto; Hiroko Hoshi; Ryotaro Iwasaki; Miyuri Kawasumi; Tokuhiro Kimura; Tami Kobayashi; Takashi Kobayashi; Hiroya Miyamoto; Yoshiteru Miyauchi; Hideo Morioka; Josef M Penninger; Yuiko Sato; Toshio Suda; Yoshiaki Toyama; Hisataka Yasuda; Shigeyuki Yoshida; Takeshi Miyamoto
Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization.
The Journal of experimental medicine 2011;208(11):2175-81.
2011: Toshio Suda; Keiyo Takubo; Gregg L Semenza
Metabolic regulation of hematopoietic stem cells in the hypoxic niche.
Cell stem cell 2011;9(4):298-310.
2011: Yoshiaki Kubota; Toshio Suda
Vascularity of nongynecological leiomyosarcoma depends on colony-stimulating factor 1 but not on vascular endothelial growth factor.
The American journal of pathology 2011;179(4):1591-3.
2011: Peng Zou; Ikue Tai; Fujiko Tsukahara; Hiroki Yoshihara; Kentaro Hosokawa; Yoshiro Maru; Keiko Nakayama; Keiichi I Nakayama; Kaori Shinmyozu; Toshio Suda
p57(Kip2) and p27(Kip1) cooperate to maintain hematopoietic stem cell quiescence through interactions with Hsc70.
Cell stem cell 2011;9(3):247-61.
2011: Yuji Okuno; Ayako Nakamura-Ishizu; Kazuo Kishi; Toshio Suda; Yoshiaki Kubota
Bone marrow-derived cells serve as proangiogenic macrophages but not endothelial cells in wound healing.
Blood 2011;117(19):5264-72.
2011: Yoshiaki Kubota; Keiyo Takubo; Masanori Hirashima; Narihito Nagoshi; Kazuo Kishi; Yuji Okuno; Ayako Nakamura-Ishizu; Keigo Sano; Masato Murakami; Masatsugu Ema; Yoshiki Omatsu; Satoru Takahashi; Takashi Nagasawa; Masabumi Shibuya; Hideyuki Okano; Toshio Suda
Isolation and function of mouse tissue resident vascular precursors marked by myelin protein zero.
The Journal of experimental medicine 2011;208(5):949-60.
2011: Eriko Nitta; Masayuki Yamashita; Kentaro Hosokawa; MingJi Xian; Keiyo Takubo; Fumio Arai; Shinichiro Nakada; Toshio Suda
Telomerase reverse transcriptase protects ATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere-independent mechanism.
Blood 2011;117(16):4169-80.
2011: Taisuke Kinoshita; Go Nagamatsu; Takeo Kosaka; Keiyo Takubo; Akitsu Hotta; James Ellis; Toshio Suda
Ataxia-telangiectasia mutated (ATM) deficiency decreases reprogramming efficiency and leads to genomic instability in iPS cells.
Biochemical and biophysical research communications 2011;407(2):321-6.
2011: Hirono Iriuchishima; Keiyo Takubo; Sahoko Matsuoka; Ichiro Onoyama; Keiichi I Nakayama; Yoshihisa Nojima; Toshio Suda
Ex vivo maintenance of hematopoietic stem cells by quiescence induction through Fbxw7α overexpression.
Blood 2011;117(8):2373-7.
2010: Haruko Shima; Keiyo Takubo; Naoko Tago; Hiroko Iwasaki; Fumio Arai; Takao Takahashi; Toshio Suda
Acquisition of G₀ state by CD34-positive cord blood cells after bone marrow transplantation.
Experimental hematology 2010;38(12):1231-40.
2010: Hideaki Nakajima; Miyuki Ito; David S Smookler; Fumi Shibata; Yumi Fukuchi; Yoshihiro Morikawa; Yuichi Ikeda; Fumio Arai; Toshio Suda; Rama Khokha; Toshio Kitamura
TIMP-3 recruits quiescent hematopoietic stem cells into active cell cycle and expands multipotent progenitor pool.
Blood 2010;116(22):4474-82.
2010: Fumiyuki Sanematsu; Masanori Hirashima; Mélanie Laurin; Ryosuke Takii; Akihiko Nishikimi; Keiko Kitajima; Guo Ding; Mamiko Noda; Yuzo Murata; Yoshihiko Tanaka; Sadahiko Masuko; Toshio Suda; Chikara Meno; Jean-François Côté; Takashi Nagasawa; Yoshinori Fukui
DOCK180 is a Rac activator that regulates cardiovascular development by acting downstream of CXCR4.
Circulation research 2010;107(9):1102-5.
2010: T Shimizu; Takatoshi Ishikawa; E Sugihara; S Kuninaka; Takeshi Miyamoto; Y Mabuchi; Y Matsuzaki; T Tsunoda; F Miya; H Morioka; R Nakayama; E Kobayashi; Yoshiaki Toyama; A Kawai; H Ichikawa; Tomonobu Hasegawa; S Okada; T Ito; Yasuo Ikeda; Toshio Suda; Hideyuki Saya
c-MYC overexpression with loss of Ink4a/Arf transforms bone marrow stromal cells into osteosarcoma accompanied by loss of adipogenesis.
Oncogene 2010;29(42):5687-99.
2010: Keiyo Takubo; Nobuhito Goda; Wakako Yamada; Hirono Iriuchishima; Eiji Ikeda; Yoshiaki Kubota; Haruko Shima; Randall S Johnson; Atsushi Hirao; Makoto Suematsu; Toshio Suda
Regulation of the HIF-1alpha level is essential for hematopoietic stem cells.
Cell stem cell 2010;7(3):391-402.
2010: Yuka Nakamura; Fumio Arai; Hiroko Iwasaki; Kentaro Hosokawa; Isao Kobayashi; Yumiko Gomei; Yoshiko Matsumoto; Hiroki Yoshihara; Toshio Suda
Isolation and characterization of endosteal niche cell populations that regulate hematopoietic stem cells.
Blood 2010;116(9):1422-32.
2010: Shinichiro Nakada; Ikue Tai; Stephanie Panier; Abdallah Al-Hakim; Shun-Ichiro Iemura; Yu-Chi Juang; Lara O'Donnell; Ayako Kumakubo; Meagan Munro; Frank Sicheri; Anne-Claude Gingras; Tohru Natsume; Toshio Suda; Daniel Durocher
Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1.
Nature 2010;466(7309):941-6.
2010: Hiroko Iwasaki; Fumio Arai; Yoshiaki Kubota; Maria Dahl; Toshio Suda
Endothelial protein C receptor-expressing hematopoietic stem cells reside in the perisinusoidal niche in fetal liver.
Blood 2010;116(4):544-53.
2010: Kentaro Hosokawa; Fumio Arai; Hiroki Yoshihara; Hiroko Iwasaki; Yuka Nakamura; Yumiko Gomei; Toshio Suda
Knockdown of N-cadherin suppresses the long-term engraftment of hematopoietic stem cells.
Blood 2010;116(4):554-63.
2010: Hakuo Takahashi; Toshio Suda; Yuetsu Tanaka; Bon Kimura
Cellular hydrophobicity of Listeria monocytogenes involves initial attachment and biofilm formation on the surface of polyvinyl chloride.
Letters in applied microbiology 2010;50(6):618-25.
2010: Toshihide Kurihara; Yoshiaki Kubota; Yoko Ozawa; Keiyo Takubo; Kousuke Noda; M Celeste Simon; Randall S Johnson; Makoto Suematsu; Kazuo Tsubota; Susumu Ishida; Nobuhito Goda; Toshio Suda; Hideyuki Okano
von Hippel-Lindau protein regulates transition from the fetal to the adult circulatory system in retina.
Development (Cambridge, England) 2010;137(9):1563-71.
2010: Yoshiteru Miyauchi; Ken Ninomiya; Hiroya Miyamoto; Akemi Sakamoto; Ryotaro Iwasaki; Hiroko Hoshi; Kana Miyamoto; Wu Hao; Shigeyuki Yoshida; Hideo Morioka; Kazuhiro Chiba; Shigeaki Kato; Takeshi Tokuhisa; Mitinori Saitou; Yoshiaki Toyama; Toshio Suda; Takeshi Miyamoto
The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis.
The Journal of experimental medicine 2010;207(4):751-62.
2010: Kentaro Hosokawa; Fumio Arai; Hiroki Yoshihara; Hiroko Iwasaki; Mark Hembree; Tong Yin; Yuka Nakamura; Yumiko Gomei; Keiyo Takubo; Haruko Shiama; Sahoko Matsuoka; Linheng Li; Toshio Suda
Cadherin-based adhesion is a potential target for niche manipulation to protect hematopoietic stem cells in adult bone marrow.
Cell stem cell 2010;6(3):194-8.
2010: Yumiko Gomei; Yuka Nakamura; Hiroki Yoshihara; Kentaro Hosokawa; Hiroko Iwasaki; Toshio Suda; Fumio Arai
Functional differences between two Tie2 ligands, angiopoietin-1 and -2, in regulation of adult bone marrow hematopoietic stem cells.
Experimental hematology 2010;38(2):82-9.
2010: Isao Kobayashi; Hiromasa Ono; Tadaaki Moritomo; Koichiro Kano; Teruyuki Nakanishi; Toshio Suda
Comparative gene expression analysis of zebrafish and mammals identifies common regulators in hematopoietic stem cells.
Blood 2010;115(2):e1-9.
2009: Kaori Harada; Tomoko Yamazaki; Caname Iwata; Yasuhiro Yoshimatsu; Hitoshi Sase; Koichi Mishima; Yasuyuki Morishita; Masanori Hirashima; Yuichi Oike; Toshio Suda; Naoyuki Miura; Tetsuro Watabe; Kohei Miyazono
Identification of targets of Prox1 during in vitro vascular differentiation from embryonic stem cells: functional roles of HoxD8 in lymphangiogenesis.
Journal of cell science 2009;122(Pt 21):3923-30.
2009: Eriko Nitta; Toshio Suda
[Cancer stem cell concepts--lesson from leukemia].
Nihon rinsho. Japanese journal of clinical medicine 2009;67(10):1863-7.
2009: Fumio Arai; Hiroki Yoshihara; Kentaro Hosokawa; Yuka Nakamura; Yumiko Gomei; Hiroko Iwasaki; Toshio Suda
Niche regulation of hematopoietic stem cells in the endosteum.
Annals of the New York Academy of Sciences 2009;1176():36-46.
2009: Mitsuhisa Tabata; Tsuyoshi Kadomatsu; Shigetomo Fukuhara; Keishi Miyata; Yasuhiro Ito; Motoyoshi Endo; Takashi Urano; Hui Juan Zhu; Hiroto Tsukano; Hirokazu Tazume; Koichi Kaikita; Kazuya Miyashita; Takao Iwawaki; Michio Shimabukuro; Kazuhiko Sakaguchi; Takaaki Ito; Naomi Nakagata; Tetsuya Yamada; Hideki Katagiri; Masato Kasuga; Yukio Ando; Hisao Ogawa; Naoki Mochizuki; Hiroshi Itoh; Toshio Suda; Yuichi Oike
Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance.
Cell metabolism 2009;10(3):178-88.
2009: Hiroko Iwasaki; Toshio Suda
Cancer stem cells and their niche.
Cancer science 2009;100(7):1166-72.
2009: Naoko Irie; Yasunari Takada; Yoshihiko Watanabe; Yumi Matsuzaki; Chie Naruse; Masahide Asano; Yoichiro Iwakura; Toshio Suda; Koichi Matsuo
Bidirectional signaling through ephrinA2-EphA2 enhances osteoclastogenesis and suppresses osteoblastogenesis.
The Journal of biological chemistry 2009;284(21):14637-44.
2009: Yoshiaki Kubota; Keiyo Takubo; Takatsune Shimizu; Hiroaki Ohno; Kazuo Kishi; Masabumi Shibuya; Hideyuki Saya; Toshio Suda
M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis.
The Journal of experimental medicine 2009;206(5):1089-102.
2009: Wakako Yamada; Kenji Nagao; Kaori Horikoshi; Ayako Fujikura; Eiji Ikeda; Yoshimasa Inagaki; Makoto Kakitani; Kazuma Tomizuka; Hiroshi Miyazaki; Toshio Suda; Keiyo Takubo
Craniofacial malformation in R-spondin2 knockout mice.
Biochemical and biophysical research communications 2009;381(3):453-8.
2009: Tai Hato; Yoshishige Kimura; Tohru Morisada; Gou Young Koh; Keishi Miyata; Mitsuhisa Tabata; Tsuyoshi Kadomatsu; Motoyoshi Endo; Takashi Urano; Fumio Arai; Kimi Araki; Toshio Suda; Koichi Kobayashi; Yuichi Oike
Angiopoietins contribute to lung development by regulating pulmonary vascular network formation.
Biochemical and biophysical research communications 2009;381(2):218-23.
2009: Hironori Adachi; Yukio Fujiwara; Tatsuya Kondo; Takeshi Nishikawa; Rei Ogawa; Takeshi Matsumura; Norio Ishii; Ryoji Nagai; Keishi Miyata; Mitsuhisa Tabata; Hiroyuki Motoshima; Noboru Furukawa; Kaku Tsuruzoe; Junji Kawashima; Motohiro Takeya; Shizuya Yamashita; Gou Young Koh; Andras Nagy; Toshio Suda; Yuichi Oike; Eiichi Araki
Angptl 4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosis.
Biochemical and biophysical research communications 2009;379(4):806-11.
2009: Yoshiaki Kubota; Toshio Suda
Feedback mechanism between blood vessels and astrocytes in retinal vascular development.
Trends in cardiovascular medicine 2009;19(2):38-43.
2009: Haruko Shima; Keiyo Takubo; Hiroko Iwasaki; Hiroki Yoshihara; Yumiko Gomei; Kentaro Hosokawa; Fumio Arai; Takao Takahashi; Toshio Suda
Reconstitution activity of hypoxic cultured human cord blood CD34-positive cells in NOG mice.
Biochemical and biophysical research communications 2009;378(3):467-72.
2009: Sadaoki Sakai; Hironari Takaishi; Kenichiro Matsuzaki; Hironori Kaneko; Mitsuru Furukawa; Yoshiteru Miyauchi; Ayako Shiraishi; Keiji Saito; Akio Tanaka; Tadatsugu Taniguchi; Toshio Suda; Takeshi Miyamoto; Yoshiaki Toyama
1-Alpha, 25-dihydroxy vitamin D3 inhibits osteoclastogenesis through IFN-beta-dependent NFATc1 suppression.
Journal of bone and mineral metabolism 2009;27(6):643-52.
2008: Ryotaro Iwasaki; Ken Ninomiya; Kana Miyamoto; Toru Suzuki; Yuiko Sato; Hiromasa Kawana; Taneaki Nakagawa; Toshio Suda; Takeshi Miyamoto
Cell fusion in osteoclasts plays a critical role in controlling bone mass and osteoblastic activity.
Biochemical and biophysical research communications 2008;377(3):899-904.
2008: Kana Miyamoto; Takeshi Miyamoto; Reiko Kato; Akihiko Yoshimura; Noboru Motoyama; Toshio Suda
FoxO3a regulates hematopoietic homeostasis through a negative feedback pathway in conditions of stress or aging.
Blood 2008;112(12):4485-93.
2008: Yumi Sawatani; Takeshi Miyamoto; Shigenori Nagai; Mikako Maruya; Jun Imai; Kana Miyamoto; Nobuyuki Fujita; Ken Ninomiya; Toru Suzuki; Ryotaro Iwasaki; Yoshiaki Toyama; Masanori Shinohara; Shigeo Koyasu; Toshio Suda
The role of DC-STAMP in maintenance of immune tolerance through regulation of dendritic cell function.
International immunology 2008;20(10):1259-68.
2008: Yoshiaki Kubota; Masanori Hirashima; Kazuo Kishi; Colin L Stewart; Toshio Suda
Leukemia inhibitory factor regulates microvessel density by modulating oxygen-dependent VEGF expression in mice.
The Journal of clinical investigation 2008;118(7):2393-403.
2008: Takashi Urano; Yasuhiro Ito; Masaki Akao; Tomohiro Sawa; Keishi Miyata; Mitsuhisa Tabata; Tohru Morisada; Tai Hato; Masato Yano; Tsuyoshi Kadomatsu; Kunio Yasunaga; Rei Shibata; Toyoaki Murohara; Takaaki Akaike; Hidenobu Tanihara; Toshio Suda; Yuichi Oike
Angiopoietin-related growth factor enhances blood flow via activation of the ERK1/2-eNOS-NO pathway in a mouse hind-limb ischemia model.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(5):827-34.
2008: Sahoko Matsuoka; Yuichi Oike; Ichiro Onoyama; Atsushi Iwama; Fumio Arai; Keiyo Takubo; Yoichi Mashimo; Hideyuki Oguro; Eriko Nitta; Keisuke Ito; Kana Miyamoto; Hiroki Yoshiwara; Kentaro Hosokawa; Yuka Nakamura; Yumiko Gomei; Hiroko Iwasaki; Yasuhide Hayashi; Yumi Matsuzaki; Keiko Nakayama; Yasuo Ikeda; Akira Hata; Shigeru Chiba; Keiichi I Nakayama; Toshio Suda
Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL.
Genes & development 2008;22(8):986-91.
2008: Kyoko Kawasaki; Tetsuro Watabe; Hitoshi Sase; Masanori Hirashima; Hiroshi Koide; Yasuyuki Morishita; Keiko Yuki; Toshikuni Sasaoka; Toshio Suda; Motoya Katsuki; Kohei Miyazono; Keiji Miyazawa
Ras signaling directs endothelial specification of VEGFR2+ vascular progenitor cells.
The Journal of cell biology 2008;181(1):131-41.
2008: Masanori Hirashima; Keigo Sano; Toru Morisada; Kyoko Murakami; Janet Rossant; Toshio Suda
Lymphatic vessel assembly is impaired in Aspp1-deficient mouse embryos.
Developmental biology 2008;316(1):149-59.
2008: Masato Murakami; Yujuan Zheng; Masanori Hirashima; Toshio Suda; Yohei Morita; Jun Ooehara; Hideo Ema; Guo-Hua Fong; Masabumi Shibuya
VEGFR1 tyrosine kinase signaling promotes lymphangiogenesis as well as angiogenesis indirectly via macrophage recruitment.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(4):658-64.
2008: Toshio Suda; Fumio Arai
Wnt signaling in the niche.
Cell 2008;132(5):729-30.
2008: Yoshiaki Kubota; Keiyo Takubo; Toshio Suda
Bone marrow long label-retaining cells reside in the sinusoidal hypoxic niche.
Biochemical and biophysical research communications 2008;366(2):335-9.
2008: Keiyo Takubo; Masako Ohmura; Masaki Azuma; Go Nagamatsu; Wakako Yamada; Fumio Arai; Atsushi Hirao; Toshio Suda
Stem cell defects in ATM-deficient undifferentiated spermatogonia through DNA damage-induced cell-cycle arrest.
Cell stem cell 2008;2(2):170-82.
2007: Hiroki Yoshihara; Fumio Arai; Kentaro Hosokawa; Tetsuya Hagiwara; Keiyo Takubo; Yuka Nakamura; Yumiko Gomei; Hiroko Iwasaki; Sahoko Matsuoka; Kana Miyamoto; Hiroshi Miyazaki; Takao Takahashi; Toshio Suda
Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche.
Cell stem cell 2007;1(6):685-97.
2007: Kentaro Hosokawa; Fumio Arai; Hiroki Yoshihara; Yuka Nakamura; Yumiko Gomei; Hiroko Iwasaki; Kana Miyamoto; Haruko Shima; Keisuke Ito; Toshio Suda
Function of oxidative stress in the regulation of hematopoietic stem cell-niche interaction.
Biochemical and biophysical research communications 2007;363(3):578-83.
2007: Toru Suzuki; Takeshi Miyamoto; Nobuyuki Fujita; Ken Ninomiya; Ryotaro Iwasaki; Yoshiaki Toyama; Toshio Suda
Osteoblast-specific Angiopoietin 1 overexpression increases bone mass.
Biochemical and biophysical research communications 2007;362(4):1019-25.
2007: Ken Ninomiya; Takeshi Miyamoto; Jun-Ichi Imai; Nobuyuki Fujita; Toru Suzuki; Ryotaro Iwasaki; Mitsuru Yagi; Shinya Watanabe; Yoshiaki Toyama; Toshio Suda
Osteoclastic activity induces osteomodulin expression in osteoblasts.
Biochemical and biophysical research communications 2007;362(2):460-6.
2007: Kozo Morita; Takeshi Miyamoto; Nobuyuki Fujita; Yoshiaki Kubota; Keisuke Ito; Keiyo Takubo; Kana Miyamoto; Ken Ninomiya; Toru Suzuki; Ryotaro Iwasaki; Mitsuru Yagi; Hironari Takaishi; Yoshiaki Toyama; Toshio Suda
Reactive oxygen species induce chondrocyte hypertrophy in endochondral ossification.
The Journal of experimental medicine 2007;204(7):1613-23.
2007: Mitsuru Yagi; Ken Ninomiya; Nobuyuki Fujita; Toru Suzuki; Ryotaro Iwasaki; Kozo Morita; Naobumi Hosogane; Koichi Matsuo; Yoshiaki Toyama; Toshio Suda; Takeshi Miyamoto
Induction of DC-STAMP by alternative activation and downstream signaling mechanisms.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007;22(7):992-1001.
2007: Kana Miyamoto; Kiyomi Y Araki; Kazuhito Naka; Fumio Arai; Keiyo Takubo; Satoshi Yamazaki; Sahoko Matsuoka; Takeshi Miyamoto; Keisuke Ito; Masako Ohmura; Chen Chen; Kentaro Hosokawa; Hiromitsu Nakauchi; Keiko Nakayama; Keiichi I Nakayama; Mine Harada; Noboru Motoyama; Toshio Suda; Atsushi Hirao
Foxo3a is essential for maintenance of the hematopoietic stem cell pool.
Cell stem cell 2007;1(1):101-12.
2007: Fumio Arai; Toshio Suda
Maintenance of quiescent hematopoietic stem cells in the osteoblastic niche.
Annals of the New York Academy of Sciences 2007;1106():41-53.
2007: Koichi Mishima; Tetsuro Watabe; Akira Saito; Yasuhiro Yoshimatsu; Natsuko Imaizumi; Shinji Masui; Masanori Hirashima; Tohru Morisada; Yuichi Oike; Makoto Araie; Hitoshi Niwa; Hajime Kubo; Toshio Suda; Kohei Miyazono
Prox1 induces lymphatic endothelial differentiation via integrin alpha9 and other signaling cascades.
Molecular biology of the cell 2007;18(4):1421-9.
2007: Chung-Hyun Cho; Young Jun Koh; Jinah Han; Hoon-Ki Sung; Hyuek Jong Lee; Tohru Morisada; Reto Schwendener; Rolf Brekken; Guson Kang; Yuichi Oike; Tae-Saeng Choi; Toshio Suda; Ook Joon Yoo; Gou Young Koh
Angiogenic role of LYVE-1-positive macrophages in adipose tissue.
Circulation research 2007;100(4):e47-57.
2007: Fumio Arai; Toshio Suda
Regulation of hematopoietic stem cells in the osteoblastic niche.
Advances in experimental medicine and biology 2007;602():61-7.
2007: Keisuke Ito; Keiyo Takubo; Fumio Arai; Hitoshi Satoh; Sahoko Matsuoka; Masako Ohmura; Kazuhito Naka; Masaki Azuma; Kana Miyamoto; Kentaro Hosokawa; Yasuo Ikeda; Tak W Mak; Toshio Suda; Atsushi Hirao
Regulation of reactive oxygen species by Atm is essential for proper response to DNA double-strand breaks in lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(1):103-10.
2006: Keiyo Takubo; Atsushi Hirao; Masako Ohmura; Masaki Azuma; Fumio Arai; Go Nagamatsu; Toshio Suda
Premeiotic germ cell defect in seminiferous tubules of Atm-null testis.
Biochemical and biophysical research communications 2006;351(4):993-8.
2006: Go Nagamatsu; Masako Ohmura; Takuo Mizukami; Isao Hamaguchi; Susumu Hirabayashi; Shosei Yoshida; Yutaka Hata; Toshio Suda; Kazuyuki Ohbo
A CTX family cell adhesion molecule, JAM4, is expressed in stem cell and progenitor cell populations of both male germ cell and hematopoietic cell lineages.
Molecular and cellular biology 2006;26(22):8498-506.
2006: Norihiro Nagai; Yuichi Oike; Kanako Izumi-Nagai; Takashi Urano; Yoshiaki Kubota; Kousuke Noda; Yoko Ozawa; Makoto Inoue; Kazuo Tsubota; Toshio Suda; Susumu Ishida
Angiotensin II type 1 receptor-mediated inflammation is required for choroidal neovascularization.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(10):2252-9.
2006: Chen Zhao; Naoko Irie; Yasunari Takada; Kouji Shimoda; Takeshi Miyamoto; Toru Nishiwaki; Toshio Suda; Koichi Matsuo
Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis.
Cell metabolism 2006;4(2):111-21.
2006: Chikako Odaka; Tohru Morisada; Yuichi Oike; Toshio Suda
Distribution of lymphatic vessels in mouse thymus: immunofluorescence analysis.
Cell and tissue research 2006;325(1):13-22.
2006: Hoon-Ki Sung; Tohru Morisada; Chung-Hyun Cho; Yuichi Oike; Jayhun Lee; Eon Ki Sung; Jae Hoon Chung; Toshio Suda; Gou Young Koh
Intestinal and peri-tumoral lymphatic endothelial cells are resistant to radiation-induced apoptosis.
Biochemical and biophysical research communications 2006;345(2):545-51.
2006: Keiyo Takubo; Atsushi Hirao; Toshio Suda
[Hematopoietic stem cell niche in bone marrow].
Seikagaku. The Journal of Japanese Biochemical Society 2006;78(4):301-9.
2006: Keisuke Ito; Atsushi Hirao; Fumio Arai; Keiyo Takubo; Sahoko Matsuoka; Kana Miyamoto; Masako Ohmura; Kazuhito Naka; Kentaro Hosokawa; Yasuo Ikeda; Toshio Suda
Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells.
Nature medicine 2006;12(4):446-51.
2006: Shosei Yoshida; Mamiko Sukeno; Toshinori Nakagawa; Kazuyuki Ohbo; Go Nagamatsu; Toshio Suda; Yo-ichi Nabeshima
The first round of mouse spermatogenesis is a distinctive program that lacks the self-renewing spermatogonia stage.
Development (Cambridge, England) 2006;133(8):1495-505.
2006: Masanori Hirashima; Toshio Suda
Differentiation of arterial and venous endothelial cells and vascular morphogenesis.
Endothelium : journal of endothelial cell research 2006;13(2):137-45.
2006: Tohru Morisada; Yoshiaki Kubota; Takashi Urano; Toshio Suda; Yuichi Oike
Angiopoietins and angiopoietin-like proteins in angiogenesis.
Endothelium : journal of endothelial cell research 2006;13(2):71-9.
2006: Isao Hamaguchi; Tohru Morisada; Masaki Azuma; Kyoko Murakami; Madoka Kuramitsu; Takuo Mizukami; Kazuyuki Ohbo; Kazunari Yamaguchi; Yuichi Oike; Daniel J Dumont; Toshio Suda
Loss of Tie2 receptor compromises embryonic stem cell-derived endothelial but not hematopoietic cell survival.
Blood 2006;107(3):1207-13.
2006: Mitsuru Yagi; Takeshi Miyamoto; Yoshiaki Toyama; Toshio Suda
Role of DC-STAMP in cellular fusion of osteoclasts and macrophage giant cells.
Journal of bone and mineral metabolism 2006;24(5):355-8.
2005: Nobuyuki Fujita; Takeshi Miyamoto; Jun-ichi Imai; Naobumi Hosogane; Toru Suzuki; Mitsuru Yagi; Kozo Morita; Ken Ninomiya; Kana Miyamoto; Hironari Takaishi; Morio Matsumoto; Hideo Morioka; Hiroo Yabe; Kazuhiro Chiba; Shinya Watanabe; Yoshiaki Toyama; Toshio Suda
CD24 is expressed specifically in the nucleus pulposus of intervertebral discs.
Biochemical and biophysical research communications 2005;338(4):1890-6.
2005: Masaki Azuma; Atsushi Hirao; Keiyo Takubo; Isao Hamaguchi; Tadaichi Kitamura; Toshio Suda
A quantitative matrigel assay for assessing repopulating capacity of prostate stem cells.
Biochemical and biophysical research communications 2005;338(2):1164-70.
2005: Fumio Arai; Atsushi Hirao; Toshio Suda
Regulation of hematopoiesis and its interaction with stem cell niches.
International journal of hematology 2005;82(5):371-6.
2005: Toshio Suda; Fumio Arai; Shigeto Shimmura
Regulation of stem cells in the niche.
Cornea 2005;24(8 Suppl):S12-S17.
2005: Yuichi Oike; Masaki Akao; Yoshiaki Kubota; Toshio Suda
Angiopoietin-like proteins: potential new targets for metabolic syndrome therapy.
Trends in molecular medicine 2005;11(10):473-9.
2005: Yoshiaki Kubota; Yuichi Oike; Shinya Satoh; Yoko Tabata; Yuichi Niikura; Tohru Morisada; Masaki Akao; Takashi Urano; Yasuhiro Ito; Takeshi Miyamoto; Norihiro Nagai; Gou Young Koh; Sumiko Watanabe; Toshio Suda
Cooperative interaction of Angiopoietin-like proteins 1 and 2 in zebrafish vascular development.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(38):13502-7.
2005: Takeshi Miyamoto; Toshio Suda
[Differentiation and function of monocyte/macrophage lineage cells and osteoblasts].
Nihon rinsho. Japanese journal of clinical medicine 2005;63(9):1511-6.
2005: Mitsuru Yagi; Takeshi Miyamoto; Yumi Sawatani; Katsuya Iwamoto; Naobumi Hosogane; Nobuyuki Fujita; Kozo Morita; Ken Ninomiya; Toru Suzuki; Kana Miyamoto; Yuichi Oike; Motohiro Takeya; Yoshiaki Toyama; Toshio Suda
DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells.
The Journal of experimental medicine 2005;202(3):345-51.
2005: Norihiro Nagai; Yuichi Oike; Kousuke Noda; Takashi Urano; Yoshiaki Kubota; Yoko Ozawa; Hajime Shinoda; Takashi Koto; Kei Shinoda; Makoto Inoue; Kazuo Tsubota; Kenji Yamashiro; Toshio Suda; Susumu Ishida
Suppression of ocular inflammation in endotoxin-induced uveitis by blocking the angiotensin II type 1 receptor.
Investigative ophthalmology & visual science 2005;46(8):2925-31.
2005: Toshio Suda; Fumio Arai; Atsushi Hirao
Hematopoietic stem cells and their niche.
Trends in immunology 2005;26(8):426-33.
2005: Tuomas Tammela; Anne Saaristo; Marja Lohela; Tohru Morisada; Jenny Tornberg; Camilla Norrmén; Yuichi Oike; Katri Pajusola; Gavin Thurston; Toshio Suda; Seppo Yla-Herttuala; Kari Alitalo
Angiopoietin-1 promotes lymphatic sprouting and hyperplasia.
Blood 2005;105(12):4642-8.
2005: Tohru Morisada; Yuichi Oike; Yoshihiro Yamada; Takashi Urano; Masaki Akao; Yoshiaki Kubota; Hiromitsu Maekawa; Yoshishige Kimura; Masako Ohmura; Takeshi Miyamoto; Shiro Nozawa; Gou Young Koh; Kari Alitalo; Toshio Suda
Angiopoietin-1 promotes LYVE-1-positive lymphatic vessel formation.
Blood 2005;105(12):4649-56.
2005: Atsushi Hirao; Fumio Arai; Keisuke Ito; Toshio Suda
[Regulation of self-renewal of hematopoietic stem cells in the niche].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2005;50(7):886-91.
2005: Yoshiaki Kubota; Yuichi Oike; Shinya Satoh; Yoko Tabata; Yuichi Niikura; Tohru Morisada; Masaki Akao; Takashi Urano; Yasuhiro Ito; Takeshi Miyamoto; Sumiko Watanabe; Toshio Suda
Isolation and expression patterns of genes for three angiopoietin-like proteins, Angptl1, 2 and 6 in zebrafish.
Gene expression patterns : GEP 2005;5(5):679-85.
2005: Hiromi Yuasa; Yuichi Oike; Atsushi Iwama; Ichiro Nishikata; Daisuke Sugiyama; Archibald Perkins; Michael L Mucenski; Toshio Suda; Kazuhiro Morishita
Oncogenic transcription factor Evi1 regulates hematopoietic stem cell proliferation through GATA-2 expression.
The EMBO journal 2005;24(11):1976-87.
2005: Yuichi Oike; Masaki Akao; Kunio Yasunaga; Toshimasa Yamauchi; Tohru Morisada; Yasuhiro Ito; Takashi Urano; Yoshishige Kimura; Yoshiaki Kubota; Hiromitsu Maekawa; Takeshi Miyamoto; Keishi Miyata; Shun-ichiro Matsumoto; Juro Sakai; Naomi Nakagata; Motohiro Takeya; Haruhiko Koseki; Yoshihiro Ogawa; Takashi Kadowaki; Toshio Suda
Angiopoietin-related growth factor antagonizes obesity and insulin resistance.
Nature medicine 2005;11(4):400-8.
2005: Keishi Miyata; Yuichi Oike; Takayuki Hoshii; Hiromitsu Maekawa; Hisao Ogawa; Toshio Suda; Kimi Araki; Ken-ichi Yamamura
Increase of smooth muscle cell migration and of intimal hyperplasia in mice lacking the alpha/beta hydrolase domain containing 2 gene.
Biochemical and biophysical research communications 2005;329(1):296-304.
2005: Norihiro Nagai; Kousuke Noda; Takashi Urano; Yoshiaki Kubota; Hajime Shinoda; Takashi Koto; Kei Shinoda; Makoto Inoue; Takayuki Shiomi; Eiji Ikeda; Kazuo Tsubota; Toshio Suda; Yuichi Oike; Susumu Ishida
Selective suppression of pathologic, but not physiologic, retinal neovascularization by blocking the angiotensin II type 1 receptor.
Investigative ophthalmology & visual science 2005;46(3):1078-84.
2005: Fumio Arai; Atsushi Hirao; Toshio Suda
Regulation of hematopoietic stem cells by the niche.
Trends in cardiovascular medicine 2005;15(2):75-9.
2004: Katsuya Iwamoto; Takeshi Miyamoto; Yumi Sawatani; Naobumi Hosogane; Isao Hamaguchi; Masamichi Takami; Kana Nomiyama; Katsumasa Takagi; Toshio Suda
Dimer formation of receptor activator of nuclear factor kappaB induces incomplete osteoclast formation.
Biochemical and biophysical research communications 2004;325(1):229-34.
2004: Atsushi Hirao; Fumio Arai; Toshio Suda
Regulation of cell cycle in hematopoietic stem cells by the niche.
Cell cycle (Georgetown, Tex.) 2004;3(12):1481-3.
2004: Takehiko Ogawa; Masako Ohmura; Yoichi Tamura; Kaoru Kita; Kazuyuki Ohbo; Toshio Suda; Yoshinobu Kubota
Derivation and morphological characterization of mouse spermatogonial stem cell lines.
Archives of histology and cytology 2004;67(4):297-306.
2004: Masako Ohmura; Shosei Yoshida; Yoshiyuki Ide; Go Nagamatsu; Toshio Suda; Kazuyuki Ohbo
Spatial analysis of germ stem cell development in Oct-4/EGFP transgenic mice.
Archives of histology and cytology 2004;67(4):285-96.
2004: Keisuke Ito; Atsushi Hirao; Fumio Arai; Sahoko Matsuoka; Keiyo Takubo; Isao Hamaguchi; Kana Nomiyama; Kentaro Hosokawa; Kazuhiro Sakurada; Naomi Nakagata; Yasuo Ikeda; Tak W Mak; Toshio Suda
Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells.
Nature 2004;431(7011):997-1002.
2004: Hiroshi Sakamoto; Xiu-Qin Zhang; Souichi Suenobu; Kazuyuki Ohbo; Minetaro Ogawa; Toshio Suda
Cell adhesion to ephrinb2 is induced by EphB4 independently of its kinase activity.
Biochemical and biophysical research communications 2004;321(3):681-7.
2004: Fumio Arai; Atsushi Hirao; Masako Ohmura; Hidetaka Sato; Sahoko Matsuoka; Keiyo Takubo; Keisuke Ito; Gou Young Koh; Toshio Suda
Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche.
Cell 2004;118(2):149-61.
2004: Mitsuhiro Uchiba; Kenji Okajima; Yuichi Oike; Yasuhiro Ito; Kenji Fukudome; Hirotaka Isobe; Toshio Suda
Activated protein C induces endothelial cell proliferation by mitogen-activated protein kinase activation in vitro and angiogenesis in vivo.
Circulation research 2004;95(1):34-41.
2004: Yuichi Oike; Kunio Yasunaga; Toshio Suda
Angiopoietin-related/angiopoietin-like proteins regulate angiogenesis.
International journal of hematology 2004;80(1):21-8.
2004: Shosei Yoshida; Ayumi Takakura; Kazuyuki Ohbo; Kuniya Abe; Junko Wakabayashi; Masayuki Yamamoto; Toshio Suda; Yo-ichi Nabeshima
Neurogenin3 delineates the earliest stages of spermatogenesis in the mouse testis.
Developmental biology 2004;269(2):447-58.
2004: Yuichi Oike; Yasuhiro Ito; Hiromitsu Maekawa; Tohru Morisada; Yoshiaki Kubota; Masaki Akao; Takashi Urano; Kunio Yasunaga; Toshio Suda
Angiopoietin-related growth factor (AGF) promotes angiogenesis.
Blood 2004;103(10):3760-5.
2003: Hiromitsu Maekawa; Yuichi Oike; Shigeru Kanda; Yasuhiro Ito; Yoshihiro Yamada; Hiroki Kurihara; Ryozo Nagai; Toshio Suda
Ephrin-B2 induces migration of endothelial cells through the phosphatidylinositol-3 kinase pathway and promotes angiogenesis in adult vasculature.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(11):2008-14.
2003: Yasuhiro Ito; Yuichi Oike; Kunio Yasunaga; Koichi Hamada; Keishi Miyata; Shun-Ichiro Matsumoto; Sumio Sugano; Hidenobu Tanihara; Yasuhiko Masuho; Toshio Suda
Inhibition of angiogenesis and vascular leakiness by angiopoietin-related protein 4.
Cancer research 2003;63(20):6651-7.
2003: Zhenghua Li; Nobuyuki Takakura; Yuichi Oike; Takanobu Imanaka; Kimi Araki; Toshio Suda; Tadashi Kaname; Tatsuya Kondo; Kuniya Abe; Ken-ichi Yamamura
Defective smooth muscle development in qkI-deficient mice.
Development, growth & differentiation 2003;45(5-6):449-62.
2003: Yuichi Oike; Kunio Yasunaga; Yasuhiro Ito; Shun-Ichiro Matsumoto; Hiromitsu Maekawa; Tohru Morisada; Fumio Arai; Naomi Nakagata; Motohiro Takeya; Yasuhiko Masuho; Toshio Suda
Angiopoietin-related growth factor (AGF) promotes epidermal proliferation, remodeling, and regeneration.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(16):9494-9.
2003: Naoyuki Takahashi; T Sasaki; Y Tsouderos; Toshio Suda
S 12911-2 inhibits osteoclastic bone resorption in vitro.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2003;18(6):1082-7.
2003: Kazuyuki Ohbo; Shosei Yoshida; Masako Ohmura; Osamu Ohneda; Takehiko Ogawa; Hideaki Tsuchiya; Takashi Kuwana; James Kehler; Kuniya Abe; Hans R Schöler; Toshio Suda
Identification and characterization of stem cells in prepubertal spermatogenesis in mice small star, filled.
Developmental biology 2003;258(1):209-25.
2003: Takeshi Miyamoto; Toshio Suda
Differentiation and function of osteoclasts.
The Keio journal of medicine 2003;52(1):1-7.
2003: Yoshihiro Yamada; Yuichi Oike; Hisao Ogawa; Yasuhiro Ito; Hajime Fujisawa; Toshio Suda; Nobuyuki Takakura
Neuropilin-1 on hematopoietic cells as a source of vascular development.
Blood 2003;101(5):1801-9.
2003: Koichi Hamada; Yuichi Oike; Yasuhiro Ito; Hiromitsu Maekawa; Keishi Miyata; Taizo Shimomura; Toshio Suda
Distinct roles of ephrin-B2 forward and EphB4 reverse signaling in endothelial cells.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(2):190-7.
2002: Hiromi Yuasa; Nobuyuki Takakura; Taizou Shimomura; Souichi Suenobu; Taketo Yamada; Hitomi Nagayama; Yuichi Oike; Toshio Suda
Analysis of human TIE2 function on hematopoietic stem cells in umbilical cord blood.
Biochemical and biophysical research communications 2002;298(5):731-7.
2002: Akihiko Mera; Moritaka Suga; Yuji Nakayama; Masayuki Ando; Toshio Suda; Naoto Yamaguchi
Redistribution of ERK/MAP kinase to uropod-like structures in interleukin-3-induced cell shape changes.
Immunology letters 2002;84(2):117-24.
2002: Yuichi Oike; Yasuhiro Ito; Koichi Hamada; Xiu-Qin Zhang; Keishi Miyata; Fumio Arai; Tomohisa Inada; Kimi Araki; Naomi Nakagata; Motohiro Takeya; Yaz Y Kisanuki; Masashi Yanagisawa; nicholas gale; Toshio Suda
Regulation of vasculogenesis and angiogenesis by EphB/ephrin-B2 signaling between endothelial cells and surrounding mesenchymal cells.
Blood 2002;100(4):1326-33.
2002: Fumio Arai; Osamu Ohneda; Takeshi Miyamoto; Xiu Qin Zhang; Toshio Suda
Mesenchymal stem cells in perichondrium express activated leukocyte cell adhesion molecule and participate in bone marrow formation.
The Journal of experimental medicine 2002;195(12):1549-63.
2002: Souichi Suenobu; Nobuyuki Takakura; Tomohisa Inada; Yoshihiro Yamada; Hiromi Yuasa; Xiu-Qin Zhang; Seiji Sakano; Yuichi Oike; Toshio Suda
A role of EphB4 receptor and its ligand, ephrin-B2, in erythropoiesis.
Biochemical and biophysical research communications 2002;293(3):1124-31.
2002: Hua Tang; Xiu-Qin Zhang; Takeshi Naruse; Kazuyuki Ohbo; Toshio Suda
Expression and function of NJ-1 surface antigen in megakaryopoiesis.
Biochemical and biophysical research communications 2002;292(3):667-74.
2002: Kisato Nosaka; Takeshi Miyamoto; Tatsunori Sakai; Hiroaki Mitsuya; Toshio Suda; Masao Matsuoka
Mechanism of hypercalcemia in adult T-cell leukemia: overexpression of receptor activator of nuclear factor kappaB ligand on adult T-cell leukemia cells.
Blood 2002;99(2):634-40.
2001: Takeshi Miyamoto; Osamu Ohneda; Fumio Arai; K Iwamoto; Seiji Okada; K Takagi; DM Anderson; Toshio Suda
Bifurcation of osteoclasts and dendritic cells from common progenitors.
Blood 2001;98(8):2544-54.
2001: Toshio Suda; Nobuyuki Takakura
Role of hematopoietic stem cells in angiogenesis.
International journal of hematology 2001;74(3):266-71.
2001: J M Quinn; Kanami Itoh; Nobuyuki Udagawa; K Hausler; Hisataka Yasuda; Nobuyuki Shima; Atsuko Mizuno; Kanji Higashio; Naoyuki Takahashi; Toshio Suda; TJ Martin; MT Gillespie
Transforming growth factor beta affects osteoclast differentiation via direct and indirect actions.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2001;16(10):1787-94.
2001: Masaya Ueno; K Igarashi; Naoki Kimura; Keisuke Okita; Makiko Takizawa; Ikuo Nobuhisa; T Kojima; T Kitamura; Ulrike Samulowitz; Dietmar Vestweber; T Shimomura; Toshio Suda; Kinichi Nakashima; Tetsuya Taga
Endomucin is expressed in embryonic dorsal aorta and is able to inhibit cell adhesion.
Biochemical and biophysical research communications 2001;287(2):501-6.
2001: K Koga; Tatemi Todaka; Motohiro Morioka; Jun-ichiro Hamada; Y Kai; S Yano; A Okamura; Nobuyuki Takakura; Toshio Suda; Yukitaka Ushio
Expression of angiopoietin-2 in human glioma cells and its role for angiogenesis.
Cancer research 2001;61(16):6248-54.
2001: Xiu-Qin Zhang; Nobuyuki Takakura; Yuichi Oike; Tomohisa Inada; nicholas gale; George D Yancopoulos; Toshio Suda
Stromal cells expressing ephrin-B2 promote the growth and sprouting of ephrin-B2(+) endothelial cells.
Blood 2001;98(4):1028-37.
2001: Kanami Itoh; Nobuyuki Udagawa; Takenobu Katagiri; S Iemura; N Ueno; Hisataka Yasuda; Kanji Higashio; J M Quinn; MT Gillespie; TJ Martin; Toshio Suda; Naoyuki Takahashi
Bone morphogenetic protein 2 stimulates osteoclast differentiation and survival supported by receptor activator of nuclear factor-kappaB ligand.
Endocrinology 2001;142(8):3656-62.
2001: Hideya Igarashi; N Kuwata; K Kiyota; K Sumita; Toshio Suda; S Ono; S R Bauer; Nobuo Sakaguchi
Localization of recombination activating gene 1/green fluorescent protein (RAG1/GFP) expression in secondary lymphoid organs after immunization with T-dependent antigens in rag1/gfp knockin mice.
Blood 2001;97(9):2680-7.
2001: Hisayuki Nomiyama; Akihiko Mera; Osamu Ohneda; Retsu Miura; Toshio Suda; Osamu Yoshie
Organization of the chemokine genes in the human and mouse major clusters of CC and CXC chemokines: diversification between the two species.
Genes and immunity 2001;2(2):110-3.
2001: Yoshihiro Yamada; Nobuyuki Takakura; H Yasue; H Ogawa; H Fujisawa; Toshio Suda
Exogenous clustered neuropilin 1 enhances vasculogenesis and angiogenesis.
Blood 2001;97(6):1671-8.
2001: T Yanai; Takenobu Katagiri; S Akiyama; Mana Imada; T Yamashita; H Chiba; Naoyuki Takahashi; Toshio Suda
Expression of mouse osteocalcin transcripts, OG1 and OG2, is differently regulated in bone tissues and osteoblast cultures.
Journal of bone and mineral metabolism 2001;19(6):345-51.
2001: Toshio Suda; Kazuo Kobayashi; E Jimi; Nobuyuki Udagawa; Naoyuki Takahashi
The molecular basis of osteoclast differentiation and activation.
Novartis Foundation symposium 2001;232():235-47; discussion 247-50.
2000: Takeshi Miyamoto; Fumio Arai; Osamu Ohneda; K Takagi; DM Anderson; Toshio Suda
An adherent condition is required for formation of multinuclear osteoclasts in the presence of macrophage colony-stimulating factor and receptor activator of nuclear factor kappa B ligand.
Blood 2000;96(13):4335-43.
2000: Masamichi Takami; Naoyuki Takahashi; Nobuyuki Udagawa; Chisato Miyaura; K Suda; Je-Tae Woo; TJ Martin; K Nagai; Toshio Suda
Intracellular calcium and protein kinase C mediate expression of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin in osteoblasts.
Endocrinology 2000;141(12):4711-9.
2000: Koichi Hamada; Yuichi Oike; Nobuyuki Takakura; Yasuhiro Ito; Lotta Jussila; Daniel J Dumont; Kari Alitalo; Toshio Suda
VEGF-C signaling pathways through VEGFR-2 and VEGFR-3 in vasculoangiogenesis and hematopoiesis.
Blood 2000;96(12):3793-800.
2000: Kanami Itoh; Nobuyuki Udagawa; K Matsuzaki; Masamichi Takami; H Amano; Toshimasa Shinki; Yutaka Ueno; Naoyuki Takahashi; Toshio Suda
Importance of membrane- or matrix-associated forms of M-CSF and RANKL/ODF in osteoclastogenesis supported by SaOS-4/3 cells expressing recombinant PTH/PTHrP receptors.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2000;15(9):1766-75.
2000: Nobuyuki Udagawa; Naoyuki Takahashi; Hisataka Yasuda; Atsuko Mizuno; Kanami Itoh; Yutaka Ueno; Toshimasa Shinki; MT Gillespie; TJ Martin; Kanji Higashio; Toshio Suda
Osteoprotegerin produced by osteoblasts is an important regulator in osteoclast development and function.
Endocrinology 2000;141(9):3478-84.
2000: Y Takano; O Sakamoto; Moritaka Suga; Toshio Suda; Masayuki Ando
Elevated levels of macrophage-stimulating protein in induced sputum of patients with bronchiectasis.
Respiratory medicine 2000;94(8):784-90.
2000: Nobuyuki Takakura; T Watanabe; Souichi Suenobu; Yoshihiro Yamada; T Noda; Yasuhiro Ito; M Satake; Toshio Suda
A role for hematopoietic stem cells in promoting angiogenesis.
Cell 2000;102(2):199-209.
2000: Chisato Miyaura; M Inada; Tetsuo Suzawa; Y Sugimoto; F Ushikubi; A Ichikawa; S Narumiya; Toshio Suda
Impaired bone resorption to prostaglandin E2 in prostaglandin E receptor EP4-knockout mice.
The Journal of biological chemistry 2000;275(26):19819-23.
2000: Tetsuo Suzawa; Chisato Miyaura; M Inada; T Maruyama; Y Sugimoto; F Ushikubi; A Ichikawa; S Narumiya; Toshio Suda
The role of prostaglandin E receptor subtypes (EP1, EP2, EP3, and EP4) in bone resorption: an analysis using specific agonists for the respective EPs.
Endocrinology 2000;141(4):1554-9.
2000: Y Onoe; Chisato Miyaura; M Ito; Hiroaki Ohta; S Nozawa; Toshio Suda
Comparative effects of estrogen and raloxifene on B lymphopoiesis and bone loss induced by sex steroid deficiency in mice.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2000;15(3):541-9.
2000: Toshio Suda; Nobuyuki Takakura; Yuichi Oike
Hematopoiesis and angiogenesis.
International journal of hematology 2000;71(2):99-107.
2000: Osamu Ohneda; Kinuko Ohneda; Hisayuki Nomiyama; Z Zheng; S A Gold; Fumio Arai; T Miyamoto; bruce taillon; McIndoe Richard; Richard A Shimkets; D A Lewin; Toshio Suda; Laurence A Lasky
WECHE: a novel hematopoietic regulatory factor.
Immunity 2000;12(2):141-50.
2000: Kazuo Kobayashi; Naoyuki Takahashi; E Jimi; Nobuyuki Udagawa; Masamichi Takami; S Kotake; N Nakagawa; Masahiko Kinosaki; Kyoji Yamaguchi; Nobuyuki Shima; Hisataka Yasuda; T Morinaga; Kanji Higashio; TJ Martin; Toshio Suda
Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction.
The Journal of experimental medicine 2000;191(2):275-86.
2000: T Tsurukai; Nobuyuki Udagawa; K Matsuzaki; Naoyuki Takahashi; Toshio Suda
Roles of macrophage-colony stimulating factor and osteoclast differentiation factor in osteoclastogenesis.
Journal of bone and mineral metabolism 2000;18(4):177-84.
1999: Fumio Arai; Takeshi Miyamoto; Osamu Ohneda; Tomohisa Inada; T Sudo; K Brasel; T Miyata; DM Anderson; Toshio Suda
Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-Fms and receptor activator of nuclear factor kappaB (RANK) receptors.
The Journal of experimental medicine 1999;190(12):1741-54.
1999: Nobuyuki Udagawa; Naoyuki Takahashi; E Jimi; K Matsuzaki; T Tsurukai; Kanami Itoh; N Nakagawa; Hisataka Yasuda; M Goto; E Tsuda; Kanji Higashio; MT Gillespie; TJ Martin; Toshio Suda
Osteoblasts/stromal cells stimulate osteoclast activation through expression of osteoclast differentiation factor/RANKL but not macrophage colony-stimulating factor: receptor activator of NF-kappa B ligand.
Bone 1999;25(5):517-23.
1999: AE el-Shazly; N Yamaguchi; K Masuyama; Toshio Suda; Takeru Ishikawa
Novel association of the src family kinases, hck and c-fgr, with CCR3 receptor stimulation: A possible mechanism for eotaxin-induced human eosinophil chemotaxis.
Biochemical and biophysical research communications 1999;264(1):163-70.
1999: XL Huang; Nobuyuki Takakura; Toshio Suda
In vitro effects of angiopoietins and VEGF on hematopoietic and endothelial cells.
Biochemical and biophysical research communications 1999;264(1):133-8.
1999: Y Yamaguchi; H Nishio; K Kishi; Steven J Ackerman; Toshio Suda
C/EBPbeta and GATA-1 synergistically regulate activity of the eosinophil granule major basic protein promoter: implication for C/EBPbeta activity in eosinophil gene expression.
Blood 1999;94(4):1429-39.
1999: Toshimasa Shinki; Yutaka Ueno; Hector F Deluca; Toshio Suda
Calcitonin is a major regulator for the expression of renal 25-hydroxyvitamin D3-1alpha-hydroxylase gene in normocalcemic rats.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(14):8253-8.
1999: Hisataka Yasuda; Nobuyuki Shima; N Nakagawa; Kyoji Yamaguchi; Masahiko Kinosaki; Masaaki Goto; S i Mochizuki; Eisuke Tsuda; T Morinaga; Nobuyuki Udagawa; Naoyuki Takahashi; Toshio Suda; Kanji Higashio
A novel molecular mechanism modulating osteoclast differentiation and function.
Bone 1999;25(1):109-13.
1999: E Jimi; S Akiyama; T Tsurukai; Nobuo Okahashi; Kazuo Kobayashi; Nobuyuki Udagawa; Tatsuji Nishihara; Naoyuki Takahashi; Toshio Suda
Osteoclast differentiation factor acts as a multifunctional regulator in murine osteoclast differentiation and function.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(1):434-42.
1999: Toshio Suda; Naoyuki Takahashi; Nobuyuki Udagawa; E Jimi; MT Gillespie; TJ Martin
Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families.
Endocrine reviews 1999;20(3):345-57.
1999: J Tada; Mitsuhiro Omine; Toshio Suda; N Yamaguchi
A common signaling pathway via Syk and Lyn tyrosine kinases generated from capping of the sialomucins CD34 and CD43 in immature hematopoietic cells.
Blood 1999;93(11):3723-35.
1999: Akihiko Mera; Moritaka Suga; Masayuki Ando; Toshio Suda; Naoto Yamaguchi
Induction of cell shape changes through activation of the interleukin-3 common beta chain receptor by the RON receptor-type tyrosine kinase.
The Journal of biological chemistry 1999;274(22):15766-74.
1999: Shigeru Kotake; N Udagawa; N Takahashi; K Matsuzaki; K Itoh; S Ishiyama; Seiji Saito; K Inoue; Naoyuki Kamatani; M T Gillespie; T J Martin; Toshio Suda
IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis.
The Journal of clinical investigation 1999;103(9):1345-52.
1999: Yuichi Oike; Nobuyuki Takakura; A Hata; Tadashi Kaname; M Akizuki; Y Yamaguchi; H Yasue; Kimi Araki; Ken-ichi Yamamura; Toshio Suda
Mice homozygous for a truncated form of CREB-binding protein exhibit defects in hematopoiesis and vasculo-angiogenesis.
Blood 1999;93(9):2771-9.
1999: Naoyuki Takahashi; Nobuyuki Udagawa; Toshio Suda
[Role of osteoclast differentiation factor, the new member of the TNF ligand family, in osteoclast differentiation and function].
Seikagaku. The Journal of Japanese Biochemical Society 1999;71(4):241-53.
1999: Yoshiko Ishimi; Chisato Miyaura; M Ohmura; Y Onoe; T Sato; Y Uchiyama; M Ito; X Wang; Toshio Suda; Sachie Ikegami
Selective effects of genistein, a soybean isoflavone, on B-lymphopoiesis and bone loss caused by estrogen deficiency.
Endocrinology 1999;140(4):1893-900.
1999: Naoyuki Takahashi; Nobuyuki Udagawa; Toshio Suda
A new member of tumor necrosis factor ligand family, ODF/OPGL/TRANCE/RANKL, regulates osteoclast differentiation and function.
Biochemical and biophysical research communications 1999;256(3):449-55.
1999: Isao Hamaguchi; XL Huang; Nobuyuki Takakura; J Tada; Y Yamaguchi; H Kodama; Toshio Suda
In vitro hematopoietic and endothelial cell development from cells expressing TEK receptor in murine aorta-gonad-mesonephros region.
Blood 1999;93(5):1549-56.
1999: E Jimi; I Nakamura; L T Duong; T Ikebe; Naoyuki Takahashi; G A Rodan; Toshio Suda
Interleukin 1 induces multinucleation and bone-resorbing activity of osteoclasts in the absence of osteoblasts/stromal cells.
Experimental cell research 1999;247(1):84-93.
1999: K Matsuzaki; K Katayama; Y Takahashi; I Nakamura; Nobuyuki Udagawa; T Tsurukai; R Nishinakamura; Yoshiaki Toyama; Y Yabe; M Hori; Naoyuki Takahashi; Toshio Suda
Human osteoclast-like cells are formed from peripheral blood mononuclear cells in a coculture with SaOS-2 cells transfected with the parathyroid hormone (PTH)/PTH-related protein receptor gene.
Endocrinology 1999;140(2):925-32.
1998: Y Duan; T Naruse; M Nakamura; Y Yamaguchi; T Kawashima; Y Morikawa; T Kitamura; Toshio Suda
Expression and functional analysis of a hemopoietic progenitor antigen, NJ-1 (114/A10), in the megakaryocytic lineage.
Biochemical and biophysical research communications 1998;253(2):401-6.
1998: Y H Gao; Toshimasa Shinki; T Yuasa; H Kataoka-Enomoto; T Komori; Toshio Suda; Akihito Yamaguchi
Potential role of cbfa1, an essential transcriptional factor for osteoblast differentiation, in osteoclastogenesis: regulation of mRNA expression of osteoclast differentiation factor (ODF).
Biochemical and biophysical research communications 1998;252(3):697-702.
1998: Nobuyuki Takakura; XL Huang; T Naruse; Isao Hamaguchi; Daniel J Dumont; G D Yancopoulos; Toshio Suda
Critical role of the TIE2 endothelial cell receptor in the development of definitive hematopoiesis.
Immunity 1998;9(5):677-86.
1998: Tadashi Yoshida; Toshiaki Monkawa; Harriet S Tenenhouse; Paul Goodyer; Toshimasa Shinki; Toshio Suda; Shu Wakino; Matsuhiko Hayashi; Takao Saruta
Two novel 1alpha-hydroxylase mutations in French-Canadians with vitamin D dependency rickets type I1.
Kidney international 1998;54(5):1437-43.
1998: T Tsurukai; Naoyuki Takahashi; E Jimi; I Nakamura; Nobuyuki Udagawa; K Nogimori; M Tamura; Toshio Suda
Isolation and characterization of osteoclast precursors that differentiate into osteoclasts on calvarial cells within a short period of time.
Journal of cellular physiology 1998;177(1):26-35.
1998: Y Yamaguchi; H Nishio; Tadashi Kasahara; Steven J Ackerman; H Koyanagi; Toshio Suda
Models of lineage switching in hematopoietic development: a new myeloid-committed eosinophil cell line (YJ) demonstrates trilineage potential.
Leukemia 1998;12(9):1430-9.
1998: A Sato; A Iwama; Nobuyuki Takakura; H Nishio; G D Yancopoulos; Toshio Suda
Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells.
International immunology 1998;10(8):1217-27.
1998: Nobuo Okahashi; M Koide; E Jimi; Toshio Suda; Tatsuji Nishihara
Caspases (interleukin-1beta-converting enzyme family proteases) are involved in the regulation of the survival of osteoclasts.
Bone 1998;23(1):33-41.
1998: K Tsukii; Nobuyuki Shima; S i Mochizuki; Kyoji Yamaguchi; Masahiko Kinosaki; Kazuki Yano; Osamu Shibata; Nobuyuki Udagawa; Hisataka Yasuda; Toshio Suda; Kanji Higashio
Osteoclast differentiation factor mediates an essential signal for bone resorption induced by 1 alpha,25-dihydroxyvitamin D3, prostaglandin E2, or parathyroid hormone in the microenvironment of bone.
Biochemical and biophysical research communications 1998;246(2):337-41.
1998: K Matsuzaki; Nobuyuki Udagawa; Naoyuki Takahashi; Kyoji Yamaguchi; Hisataka Yasuda; Nobuyuki Shima; T Morinaga; Yoshiaki Toyama; Y Yabe; Kanji Higashio; Toshio Suda
Osteoclast differentiation factor (ODF) induces osteoclast-like cell formation in human peripheral blood mononuclear cell cultures.
Biochemical and biophysical research communications 1998;246(1):199-204.
1998: Toshio Suda
Lessons from the space experiment SL-J/FMPT/L7: the effect of microgravity on chicken embryogenesis and bone formation.
Bone 1998;22(5 Suppl):73S-78S.
1998: Y Yamaguchi; Steven J Ackerman; N Minegishi; M Takiguchi; Masayuki Yamamoto; Toshio Suda
Mechanisms of transcription in eosinophils: GATA-1, but not GATA-2, transactivates the promoter of the eosinophil granule major basic protein gene.
Blood 1998;91(9):3447-58.
1998: I Nakamura; E Jimi; L T Duong; T Sasaki; Naoyuki Takahashi; G A Rodan; Toshio Suda
Tyrosine phosphorylation of p130Cas is involved in actin organization in osteoclasts.
The Journal of biological chemistry 1998;273(18):11144-9.
1998: Atsushi Hirao; X L Huang; Toshio Suda; Naoto Yamaguchi
Overexpression of C-terminal Src kinase homologous kinase suppresses activation of Lyn tyrosine kinase required for VLA5-mediated Dami cell spreading.
The Journal of biological chemistry 1998;273(16):10004-10.
1998: E Jimi; I Nakamura; T Ikebe; S Akiyama; Naoyuki Takahashi; Toshio Suda
Activation of NF-kappaB is involved in the survival of osteoclasts promoted by interleukin-1.
The Journal of biological chemistry 1998;273(15):8799-805.
1998: Hisataka Yasuda; Nobuyuki Shima; N Nakagawa; Kyoji Yamaguchi; Masahiko Kinosaki; S i Mochizuki; Akihiro Tomoyasu; Kazuki Yano; Masaaki Goto; Akihiko Murakami; Eisuke Tsuda; T Morinaga; Kanji Higashio; Nobuyuki Udagawa; Naoyuki Takahashi; Toshio Suda
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(7):3597-602.
1998: K Kusano; Chisato Miyaura; M Inada; T Tamura; A Ito; H Nagase; K Kamoi; Toshio Suda
Regulation of matrix metalloproteinases (MMP-2, -3, -9, and -13) by interleukin-1 and interleukin-6 in mouse calvaria: association of MMP induction with bone resorption.
Endocrinology 1998;139(3):1338-45.
1998: HL Brenza; Christine Kimmel-Jehan; Frédéric Jehan; Toshimasa Shinki; Shu Wakino; H Anazawa; Toshio Suda; Hector F Deluca
Parathyroid hormone activation of the 25-hydroxyvitamin D3-1alpha-hydroxylase gene promoter.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(4):1387-91.
1998: Y Yamaguchi; L I Zon; Steven J Ackerman; Masayuki Yamamoto; Toshio Suda
Forced GATA-1 expression in the murine myeloid cell line M1: induction of c-Mpl expression and megakaryocytic/erythroid differentiation.
Blood 1998;91(2):450-7.
1998: Yusuke Nakamura; Yoshiyuki Hakeda; Nobuyuki Takakura; T Kameda; Isao Hamaguchi; Takeshi Miyamoto; S Kakudo; T Nakano; Masayoshi Kumegawa; Toshio Suda
Tyro 3 receptor tyrosine kinase and its ligand, Gas6, stimulate the function of osteoclasts.
Stem cells (Dayton, Ohio) 1998;16(3):229-38.
1997: Toshimasa Shinki; H Shimada; Shu Wakino; H Anazawa; Matsuhiko Hayashi; Takao Saruta; Hector F Deluca; Toshio Suda
Cloning and expression of rat 25-hydroxyvitamin D3-1alpha-hydroxylase cDNA.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(24):12920-5.
1997: K Kawasaki; Y H Gao; S Yokose; Y Kaji; T Nakamura; Toshio Suda; K Yoshida; T Taga; T Kishimoto; H Kataoka; T Yuasa; H Norimatsu; Akihito Yamaguchi
Osteoclasts are present in gp130-deficient mice.
Endocrinology 1997;138(11):4959-65.
1997: Toshiaki Monkawa; Tadashi Yoshida; Shu Wakino; Toshimasa Shinki; H Anazawa; Hector F Deluca; Toshio Suda; Matsuhiko Hayashi; Takao Saruta
Molecular cloning of cDNA and genomic DNA for human 25-hydroxyvitamin D3 1 alpha-hydroxylase.
Biochemical and biophysical research communications 1997;239(2):527-33.
1997: Y Onoe; Chisato Miyaura; Hiroaki Ohta; S Nozawa; Toshio Suda
Expression of estrogen receptor beta in rat bone.
Endocrinology 1997;138(10):4509-12.
1997: N Yamamoto; S Akiyama; Takenobu Katagiri; Mikio Namiki; T Kurokawa; Toshio Suda
Smad1 and smad5 act downstream of intracellular signalings of BMP-2 that inhibits myogenic differentiation and induces osteoblast differentiation in C2C12 myoblasts.
Biochemical and biophysical research communications 1997;238(2):574-80.
1997: S Akiyama; Takenobu Katagiri; M Namiki; N Yamaji; N Yamamoto; K Miyama; H Shibuya; Noriko Ueno; John M Wozney; Toshio Suda
Constitutively active BMP type I receptors transduce BMP-2 signals without the ligand in C2C12 myoblasts.
Experimental cell research 1997;235(2):362-9.
1997: M Namiki; S Akiyama; Takenobu Katagiri; A Suzuki; Noriko Ueno; N Yamaji; Vicki Rosen; John M Wozney; Toshio Suda
A kinase domain-truncated type I receptor blocks bone morphogenetic protein-2-induced signal transduction in C2C12 myoblasts.
The Journal of biological chemistry 1997;272(35):22046-52.
1997: Chisato Miyaura; Y Onoe; M Inada; K Maki; K Ikuta; M Ito; Toshio Suda
Increased B-lymphopoiesis by interleukin 7 induces bone loss in mice with intact ovarian function: similarity to estrogen deficiency.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(17):9360-5.
1997: I Nakamura; T Sasaki; Sakae Tanaka; Naoyuki Takahashi; E Jimi; T Kurokawa; Yoshihiro Kita; S Ihara; Toshio Suda; Y Fukui
Phosphatidylinositol-3 kinase is involved in ruffled border formation in osteoclasts.
Journal of cellular physiology 1997;172(2):230-9.
1997: Nobuo Okahashi; I Nakamura; E Jimi; M Koide; Toshio Suda; Tatsuji Nishihara
Specific inhibitors of vacuolar H(+)-ATPase trigger apoptotic cell death of osteoclasts.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1997;12(7):1116-23.
1997: M Yano; A Iwama; H Nishio; J Suda; G Takada; Toshio Suda
Expression and function of murine receptor tyrosine kinases, TIE and TEK, in hematopoietic stem cells.
Blood 1997;89(12):4317-26.
1997: T Ishizuya; S Yokose; M Hori; T Noda; Toshio Suda; S Yoshiki; Akihito Yamaguchi
Parathyroid hormone exerts disparate effects on osteoblast differentiation depending on exposure time in rat osteoblastic cells.
The Journal of clinical investigation 1997;99(12):2961-70.
1997: M Ikebe; K Miyakawa; K Takahashi; Kazuyuki Ohbo; M Nakamura; K Sugamura; Toshio Suda; K Yamamura; Kimio Tomita
Lymphohaematopoietic abnormalities and systemic lymphoproliferative disorder in interleukin-2 receptor gamma chain-deficient mice.
International journal of experimental pathology 1997;78(3):133-48.
1997: Toshio Suda; I Nakamura; E Jimi; Naoyuki Takahashi
Regulation of osteoclast function.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1997;12(6):869-79.
1997: H Tai; Chisato Miyaura; Carol Pilbeam; T Tamura; Yoshiyuki Ohsugi; Y Koishihara; N Kubodera; H Kawaguchi; L G Raisz; Toshio Suda
Transcriptional induction of cyclooxygenase-2 in osteoblasts is involved in interleukin-6-induced osteoclast formation.
Endocrinology 1997;138(6):2372-9.
1997: Y Miyamoto; Toshimasa Shinki; K Yamamoto; Y Ohyama; H Iwasaki; R Hosotani; T Kasama; H Takayama; S Yamada; Toshio Suda
1alpha,25-dihydroxyvitamin D3-24-hydroxylase (CYP24) hydroxylates the carbon at the end of the side chain (C-26) of the C-24-fluorinated analog of 1alpha,25-dihydroxyvitamin D3.
The Journal of biological chemistry 1997;272(22):14115-9.
1997: Atsushi Hirao; Isao Hamaguchi; Toshio Suda; Naoto Yamaguchi
Translocation of the Csk homologous kinase (Chk/Hyl) controls activity of CD36-anchored Lyn tyrosine kinase in thrombin-stimulated platelets.
The EMBO journal 1997;16(9):2342-51.
1997: H Murakami; Naoyuki Takahashi; Sakae Tanaka; I Nakamura; Nobuyuki Udagawa; S Nakajo; K Nakaya; M Abe; Y Yuda; F Konno; A Barbier; Toshio Suda
Tiludronate inhibits protein tyrosine phosphatase activity in osteoclasts.
Bone 1997;20(5):399-404.
1997: A Kume; H Nishiura; J Suda; Toshio Suda
Focal adhesion kinase upregulated by granulocyte-macrophage colony-stimulating factor but not by interleukin-3 in differentiating myeloid cells.
Blood 1997;89(9):3434-42.
1997: Tomohisa Inada; A Iwama; Seiji Sakano; M Ohno; K Sawada; Toshio Suda
Selective expression of the receptor tyrosine kinase, HTK, on human erythroid progenitor cells.
Blood 1997;89(8):2757-65.
1997: Toshio Suda; A Iwama; M Hashiyama; Seiji Sakano; M Ohno
Receptor tyrosine kinases involved in hematopoietic progenitor cells.
Leukemia 1997;11 Suppl 3():451-3.
1997: Q R Chen; Chisato Miyaura; S Higashi; Makoto Murakami; Ichiro Kudo; S Saito; T Hiraide; Y Shibasaki; Toshio Suda
Activation of cytosolic phospholipase A2 by platelet-derived growth factor is essential for cyclooxygenase-2-dependent prostaglandin E2 synthesis in mouse osteoblasts cultured with interleukin-1.
The Journal of biological chemistry 1997;272(9):5952-8.
1997: O Sakamoto; A Iwama; R Amitani; T Takehara; Naoto Yamaguchi; T Yamamoto; K Masuyama; T Yamanaka; Masayuki Ando; Toshio Suda
Role of macrophage-stimulating protein and its receptor, RON tyrosine kinase, in ciliary motility.
The Journal of clinical investigation 1997;99(4):701-9.
1997: Takenobu Katagiri; S Akiyama; M Namiki; M Komaki; A Yamaguchi; Vicki Rosen; John M Wozney; A Fujisawa-Sehara; Toshio Suda
Bone morphogenetic protein-2 inhibits terminal differentiation of myogenic cells by suppressing the transcriptional activity of MyoD and myogenin.
Experimental cell research 1997;230(2):342-51.
1997: I Nakamura; Naoyuki Takahashi; Nobuyuki Udagawa; Y Moriyama; T Kurokawa; E Jimi; T Sasaki; Toshio Suda
Lack of vacuolar proton ATPase association with the cytoskeleton in osteoclasts of osteosclerotic (oc/oc) mice.
FEBS letters 1997;401(2-3):207-12.
1997: Toshio Suda; Chisato Miyaura
Pathogenesis of bone loss due to estrogen deficiency.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 1997;7 Suppl 3():S43-6.
1997: Toshio Suda; E Jimi; I Nakamura; Naoyuki Takahashi
Role of 1 alpha,25-dihydroxyvitamin D3 in osteoclast differentiation and function.
Methods in enzymology 1997;282():223-35.
1996: I Nakamura; Naoyuki Takahashi; Takahisa Sasaki; E Jimi; T Kurokawa; Toshio Suda
Chemical and physical properties of the extracellular matrix are required for the actin ring formation in osteoclasts.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1996;11(12):1873-9.
1996: A Iwama; Naoto Yamaguchi; Toshio Suda
STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family.
The EMBO journal 1996;15(21):5866-75.
1996: K Ohshiro; A Iwama; K Matsuno; T Ezaki; O Sakamoto; Isao Hamaguchi; N Takasu; Toshio Suda
Molecular cloning of rat macrophage-stimulating protein and its involvement in the male reproductive system.
Biochemical and biophysical research communications 1996;227(1):273-80.
1996: Seiji Sakano; R Serizawa; T Inada; A Iwama; A Itoh; C Kato; Y Shimizu; F Shinkai; R Shimizu; S Kondo; M Ohno; Toshio Suda
Characterization of a ligand for receptor protein-tyrosine kinase HTK expressed in immature hematopoietic cells.
Oncogene 1996;13(4):813-22.
1996: E Jimi; I Nakamura; H Amano; Y Taguchi; T Tsurukai; M Tamura; Naoyuki Takahashi; Toshio Suda
Osteoclast function is activated by osteoblastic cells through a mechanism involving cell-to-cell contact.
Endocrinology 1996;137(8):2187-90.
1996: Isao Hamaguchi; Naoto Yamaguchi; J Suda; A Iwama; Atsushi Hirao; M Hashiyama; Shinichi Aizawa; Toshio Suda
Analysis of CSK homologous kinase (CHK/HYL) in hematopoiesis by utilizing gene knockout mice.
Biochemical and biophysical research communications 1996;224(1):172-9.
1996: S Kanazawa; D Ilic; M Hashiyama; M Okada; T Noumura; Shinichi Aizawa; Toshio Suda
Impaired development of CD4+ CD8+ thymoyctes by csk-'knock-in' into fyn locus.
Oncogene 1996;13(1):199-204.
1996: N Iwamoto; Tatsuya Kawaguchi; Kentaro Horikawa; Shoichi Nagakura; Tadashi Kagimoto; Toshio Suda; Kiyoshi Takatsuki; Hideki Nakakuma
Preferential hematopoiesis by paroxysmal nocturnal hemoglobinuria clone engrafted in SCID mice.
Blood 1996;87(12):4944-8.
1996: M Inada; Takenobu Katagiri; S Akiyama; M Namika; M Komaki; A Yamaguchi; K Kamoi; Vicki Rosen; Toshio Suda
Bone morphogenetic protein-12 and -13 inhibit terminal differentiation of myoblasts, but do not induce their differentiation into osteoblasts.
Biochemical and biophysical research communications 1996;222(2):317-22.
1996: E Jimi; I Nakamura; H Amano; Y Taguchi; T Tsurukai; M Tamura; Naoyuki Takahashi; Toshio Suda
Osteoclast function is activated by osteoblastic cells through a mechanism involving cell-to-cell contact.
Endocrinology 1996;137(5):2187-90.
1996: E Jimi; T Ikebe; Naoyuki Takahashi; M Hirata; Toshio Suda; Tetsuya Koga
Interleukin-1 alpha activates an NF-kappaB-like factor in osteoclast-like cells.
The Journal of biological chemistry 1996;271(9):4605-8.
1996: S Yokose; T Ishizuya; T Ikeda; T Nakamura; H Tsurukami; K Kawasaki; Toshio Suda; S Yoshiki; A Yamaguchi
An estrogen deficiency caused by ovariectomy increases plasma levels of systemic factors that stimulate proliferation and differentiation of osteoblasts in rats.
Endocrinology 1996;137(2):469-78.
1996: S Kanazawa; D Ilić; M Hashiyama; T Noumura; Takashi Yamamoto; Toshio Suda; Shinichi Aizawa
p59fyn-p125FAK cooperation in development of CD4+CD8+ thymocytes.
Blood 1996;87(3):865-70.
1996: Y Onoe; Chisato Miyaura; T Kaminakayashiki; Y Nagai; K Noguchi; Q R Chen; H Seo; H Ohta; S Nozawa; Ichiro Kudo; Toshio Suda
IL-13 and IL-4 inhibit bone resorption by suppressing cyclooxygenase-2-dependent prostaglandin synthesis in osteoblasts.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(2):758-64.
1996: Shu Wakino; M Meguro; H Suzuki; Takao Saruta; T Ogishima; H Shimada; Yuzuru Ishimura; Toshimasa Shinki; Toshio Suda
Evidence for 54-kD protein in chicken kidney as a cytochrome P450 with a high molecular activity of 25-hydroxyvitamin D3 1 alpha-hydroxylase.
Gerontology 1996;42 Suppl 1():67-77.
1996: M Hashiyama; A Iwama; K Ohshiro; K Kurozumi; K Yasunaga; Y Shimizu; Y Masuho; I Matsuda; Naoto Yamaguchi; Toshio Suda
Predominant expression of a receptor tyrosine kinase, TIE, in hematopoietic stem cells and B cells.
Blood 1996;87(1):93-101.
1995: Nobuyuki Udagawa; Naoyuki Takahashi; T Katagiri; T Tamura; S Wada; D M Findlay; T J Martin; H Hirota; T Taga; T Kishimoto; Toshio Suda
Interleukin (IL)-6 induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors.
The Journal of experimental medicine 1995;182(5):1461-8.
1995: A Iwama; M H Wang; Naoto Yamaguchi; N Ohno; K Okano; T Sudo; Motohiro Takeya; Francine Gervais; Céline Morissette; E J Leonard; Toshio Suda
Terminal differentiation of murine resident peritoneal macrophages is characterized by expression of the STK protein tyrosine kinase, a receptor for macrophage-stimulating protein.
Blood 1995;86(9):3394-403.
1995: Toshio Suda; Nobuyuki Udagawa; I Nakamura; Chisato Miyaura; Naoyuki Takahashi
Modulation of osteoclast differentiation by local factors.
Bone 1995;17(2 Suppl):87S-91S.
1995: H Murakami; Naoyuki Takahashi; Takahisa Sasaki; Nobuyuki Udagawa; Sakae Tanaka; I Nakamura; D Zhang; A Barbier; Toshio Suda
A possible mechanism of the specific action of bisphosphonates on osteoclasts: tiludronate preferentially affects polarized osteoclasts having ruffled borders.
Bone 1995;17(2):137-44.
1995: Sakae Tanaka; Naoyuki Takahashi; Nobuyuki Udagawa; H Murakami; I Nakamura; T Kurokawa; Toshio Suda
Possible involvement of focal adhesion kinase, p125FAK, in osteoclastic bone resorption.
Journal of cellular biochemistry 1995;58(4):424-35.
1995: K Iida; Toshimasa Shinki; A Yamaguchi; Hector F Deluca; K Kurokawa; Toshio Suda
A possible role of vitamin D receptors in regulating vitamin D activation in the kidney.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(13):6112-6.
1995: O Sakamoto; M Hashiyama; A Minty; Masayuki Ando; Toshio Suda
Interleukin-13 selectively suppresses the growth of human macrophage progenitors at the late stage.
Blood 1995;85(12):3487-93.
1995: I Nakamura; Naoyuki Takahashi; Takahisa Sasaki; Sakae Tanaka; Nobuyuki Udagawa; H Murakami; K Kimura; Y Kabuyama; T Kurokawa; Toshio Suda
Wortmannin, a specific inhibitor of phosphatidylinositol-3 kinase, blocks osteoclastic bone resorption.
FEBS letters 1995;361(1):79-84.
1995: Toshio Suda
[Functional molecules expressed in hematopoietic stem cells].
Seikagaku. The Journal of Japanese Biochemical Society 1995;67(3):190-203.
1994: Takenobu Katagiri; A Yamaguchi; M Komaki; E Abe; N Takahashi; T Ikeda; Vicki Rosen; John M Wozney; A Fujisawa-Sehara; Toshio Suda
Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage.
The Journal of cell biology 1994;127(6 Pt 1):1755-66.
1994: Isao Hamaguchi; A Iwama; Naoto Yamaguchi; Seiji Sakano; Y Matsuda; Toshio Suda
Characterization of mouse non-receptor tyrosine kinase gene, HYL.
Oncogene 1994;9(11):3371-4.
1994: T Masuzawa; Chisato Miyaura; Y Onoe; K Kusano; H Ohta; S Nozawa; Toshio Suda
Estrogen deficiency stimulates B lymphopoiesis in mouse bone marrow.
The Journal of clinical investigation 1994;94(3):1090-7.
1994: A Iwama; K Okano; T Sudo; Y Matsuda; Toshio Suda
Molecular cloning of a novel receptor tyrosine kinase gene, STK, derived from enriched hematopoietic stem cells.
Blood 1994;83(11):3160-9.
1994: Naoyuki Takahashi; Nobuyuki Udagawa; Sakae Tanaka; H Murakami; I Owan; T Tamura; Toshio Suda
Postmitotic osteoclast precursors are mononuclear cells which express macrophage-associated phenotypes.
Developmental biology 1994;163(1):212-21.
1994: A Nishimura; Toshimasa Shinki; C H Jin; Y Ohyama; Mitsuhide Noshiro; K Okuda; Toshio Suda
Regulation of messenger ribonucleic acid expression of 1 alpha,25-dihydroxyvitamin D3-24-hydroxylase in rat osteoblasts.
Endocrinology 1994;134(4):1794-9.
1994: Seiji Sakano; A Iwama; J Inazawa; T Ariyama; M Ohno; Toshio Suda
Molecular cloning of a novel non-receptor tyrosine kinase, HYL (hematopoietic consensus tyrosine-lacking kinase).
Oncogene 1994;9(4):1155-61.
1994: Toshio Suda; E Abe; Toshimasa Shinki; T Katagiri; A Yamaguchi; S Yokose; S Yoshiki; H Horikawa; G W Cohen; S Yasugi
The role of gravity in chick embryogenesis.
FEBS letters 1994;340(1-2):34-8.
1994: Toshio Suda; Toshimasa Shinki; K Kurokawa
The mechanisms of regulation of vitamin D metabolism in the kidney.
Current opinion in nephrology and hypertension 1994;3(1):59-64.
1993: A Iwama; Isao Hamaguchi; M Hashiyama; Y Murayama; K Yasunaga; Toshio Suda
Molecular cloning and characterization of mouse TIE and TEK receptor tyrosine kinase genes and their expression in hematopoietic stem cells.
Biochemical and biophysical research communications 1993;195(1):301-9.
1993: Takenobu Katagiri; Toshio Suda; A Yamaguchi; Hiromichi Tanaka; S Omura
[Bone formation and BMPs].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1993;38(11):1671-83.
1993: T Tamura; Naoyuki Takahashi; T Akatsu; Takahisa Sasaki; Nobuyuki Udagawa; Sakae Tanaka; Toshio Suda
New resorption assay with mouse osteoclast-like multinucleated cells formed in vitro.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1993;8(8):953-60.
1993: T Sato; E Abe; C H Jin; M H Hong; T Katagiri; T Kinoshita; N Amizuka; H Ozawa; Toshio Suda
The biological roles of the third component of complement in osteoclast formation.
Endocrinology 1993;133(1):397-404.
1993: C Miyaura; Toshio Suda
[Vitamin D].
Nihon rinsho. Japanese journal of clinical medicine 1993;51(4):893-900.
1993: Toshio Suda; Sakae Tanaka; Naoyuki Takahashi
Macrophage colon-stimulating factor (M-CSF) is essential for differentiation rather than proliferation of osteoclast progenitors.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 1993;3 Suppl 1():111-3.
1993: Sakae Tanaka; Naoyuki Takahashi; Nobuyuki Udagawa; T Tamura; T Akatsu; E Richard Stanley; T Kurokawa; Toshio Suda
Macrophage colony-stimulating factor is indispensable for both proliferation and differentiation of osteoclast progenitors.
The Journal of clinical investigation 1993;91(1):257-63.
1992: Sakae Tanaka; Naoyuki Takahashi; Nobuyuki Udagawa; Takahisa Sasaki; Y Fukui; T Kurokawa; Toshio Suda
Osteoclasts express high levels of p60c-src, preferentially on ruffled border membranes.
FEBS letters 1992;313(1):85-9.
1992: C H Jin; Toshimasa Shinki; M H Hong; T Sato; A Yamaguchi; T Ikeda; S Yoshiki; E Abe; Toshio Suda
1 alpha,25-dihydroxyvitamin D3 regulates in vivo production of the third component of complement (C3) in bone.
Endocrinology 1992;131(5):2468-75.
1992: T Akatsu; T Tamura; Naoyuki Takahashi; Nobuyuki Udagawa; Sakae Tanaka; Takahisa Sasaki; A Yamaguchi; N Nagata; Toshio Suda
Preparation and characterization of a mouse osteoclast-like multinucleated cell population.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1992;7(11):1297-306.
1992: T Tamura; Chisato Miyaura; I Owan; Toshio Suda
Mechanism of action of amylin in bone.
Journal of cellular physiology 1992;153(1):6-14.
1992: N Udagawa; J Takito; Toshio Suda
[Mechanism of acid production and secretion by osteoclasts].
Nihon rinsho. Japanese journal of clinical medicine 1992;50(9):2133-8.
1992: T Ikeda; S Nomura; A Yamaguchi; Toshio Suda; S Yoshiki
In situ hybridization of bone matrix proteins in undecalcified adult rat bone sections.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1992;40(8):1079-88.
1992: Toshimasa Shinki; C H Jin; A Nishimura; Y Nagai; Y Ohyama; Mitsuhide Noshiro; K Okuda; Toshio Suda
Parathyroid hormone inhibits 25-hydroxyvitamin D3-24-hydroxylase mRNA expression stimulated by 1 alpha,25-dihydroxyvitamin D3 in rat kidney but not in intestine.
The Journal of biological chemistry 1992;267(19):13757-62.
1992: Toshio Suda; Naoyuki Takahashi; E Abe
Role of vitamin D in bone resorption.
Journal of cellular biochemistry 1992;49(1):53-8.
1992: J Takito; Toshimasa Shinki; Hiromichi Tanaka; Toshio Suda
Mechanism of regulation of calcium-pumping activity in chick intestine.
The American journal of physiology 1992;262(5 Pt 1):G797-805.
1992: Nobuyuki Udagawa; Takahisa Sasaki; T Akatsu; Naoyuki Takahashi; Sakae Tanaka; T Tamura; Hiromichi Tanaka; Toshio Suda
Lack of bone resorption in osteosclerotic (oc/oc) mice is due to a defect in osteoclast progenitors rather than the local microenvironment provided by osteoblastic cells.
Biochemical and biophysical research communications 1992;184(1):67-72.
1992: M Shionome; T Shinki; Naoyuki Takahashi; Kohji Hasegawa; Toshio Suda
1 alpha,25-dihydroxyvitamin D3 modulation in lipid metabolism in established bone marrow-derived stromal cells, MC3T3-G2/PA6.
Journal of cellular biochemistry 1992;48(4):424-30.
1992: Toshio Suda; Naoyuki Takahashi; TJ Martin
Modulation of osteoclast differentiation.
Endocrine reviews 1992;13(1):66-80.
1992: E Abe; C H Jin; M H Hong; T Sato; Toshimasa Shinki; Toshio Suda
Tissue-specific production of the third component of complement(C3) by vitamin D in bone.
Journal of nutritional science and vitaminology 1992;Spec No():88-91.
1991: M H Hong; C H Jin; T Sato; Y Ishimi; E Abe; Toshio Suda
Transcriptional regulation of the production of the third component of complement (C3) by 1 alpha,25-dihydroxyvitamin D3 in mouse marrow-derived stromal cells (ST2) and primary osteoblastic cells.
Endocrinology 1991;129(5):2774-9.
1991: E Abe; Y Ishimi; C H Jin; M H Hong; T Sato; Toshio Suda
Granulocyte-macrophage colony-stimulating factor is a major macrophage fusion factor present in conditioned medium of concanavalin A-stimulated spleen cell cultures.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(6):1810-5.
1991: Naoyuki Takahashi; Nobuyuki Udagawa; T Akatsu; Hiromichi Tanaka; M Shionome; Toshio Suda
Role of colony-stimulating factors in osteoclast development.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1991;6(9):977-85.
1991: T Sato; M H Hong; C H Jin; Y Ishimi; Nobuyuki Udagawa; Toshimasa Shinki; E Abe; Toshio Suda
The specific production of the third component of complement by osteoblastic cells treated with 1 alpha,25-dihydroxyvitamin D3.
FEBS letters 1991;285(1):21-4.
1991: A Yamaguchi; Takenobu Katagiri; T Ikeda; John M Wozney; Vicki Rosen; E A Wang; A J Kahn; Toshio Suda; S Yoshiki
Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro.
The Journal of cell biology 1991;113(3):681-7.
1991: Naoyuki Takahashi; Nobuyuki Udagawa; T Akatsu; Hiromichi Tanaka; Y Isogai; Toshio Suda
Deficiency of osteoclasts in osteopetrotic mice is due to a defect in the local microenvironment provided by osteoblastic cells.
Endocrinology 1991;128(4):1792-6.
1991: T Akatsu; Naoyuki Takahashi; Nobuyuki Udagawa; K Imamura; A Yamaguchi; K Sato; N Nagata; Toshio Suda
Role of prostaglandins in interleukin-1-induced bone resorption in mice in vitro.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1991;6(2):183-9.
1991: S Saito; K Yamasaki; Shoji Yamada; A Matsumoto; T Akatsu; N Takahashi; Y Shibasaki; Toshio Suda; T Fukuhara
A stable analogue of thromboxane A2, 9,11-epithio-11,12-methanothromboxane A2, stimulates bone resorption in vitro and osteoclast-like cell formation in mouse marrow culture.
Bone and mineral 1991;12(1):15-23.
1991: Toshimasa Shinki; Hiromichi Tanaka; J Takito; A Yamaguchi; Y Nakamura; S Yoshiki; Toshio Suda
Putrescine is involved in the vitamin D action in chick intestine.
Gastroenterology 1991;100(1):113-22.
1991: Hiromichi Tanaka; Toshimasa Shinki; J Takito; C H Jin; Toshio Suda
Transglutaminase is involved in the fusion of mouse alveolar macrophages induced by 1 alpha, 25-dihydroxyvitamin D3.
Experimental cell research 1991;192(1):165-72.
1990: C H Jin; Chisato Miyaura; Y Ishimi; M H Hong; T Sato; E Abe; Toshio Suda
Interleukin 1 regulates the expression of osteopontin mRNA by osteoblasts.
Molecular and cellular endocrinology 1990;74(3):221-8.
1990: Takenobu Katagiri; A Yamaguchi; T Ikeda; S Yoshiki; John M Wozney; Vicki Rosen; E A Wang; Hiromichi Tanaka; S Omura; Toshio Suda
The non-osteogenic mouse pluripotent cell line, C3H10T1/2, is induced to differentiate into osteoblastic cells by recombinant human bone morphogenetic protein-2.
Biochemical and biophysical research communications 1990;172(1):295-9.
1990: T Takahashi; Naoto Yamaguchi; Seiji Mita; Y Yamaguchi; Toshio Suda; A Tominaga; Yuji Kikuchi; Y Miura; Kiyoshi Takatsu
Structural comparison of murine T-cell (B151K12)-derived T-cell-replacing factor (IL-5) with rIL-5: dimer formation is essential for the expression of biological activity.
Molecular immunology 1990;27(9):911-20.
1990: Nobuyuki Udagawa; Naoyuki Takahashi; T Akatsu; Hiromichi Tanaka; Takahisa Sasaki; T Nishihara; T Koga; T J Martin; Toshio Suda
Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(18):7260-4.
1990: K Imamura; H Ozawa; T Hiraide; Naoyuki Takahashi; Yoshinobu Shibasaki; T Fukuhara; Toshio Suda
Continuously applied compressive pressure induces bone resorption by a mechanism involving prostaglandin E2 synthesis.
Journal of cellular physiology 1990;144(2):222-8.
1990: Shin-Ichi Hayashi; T Kunisada; M Ogawa; T Sudo; H Kodama; Toshio Suda; S Nishikawa; S Nishikawa
Stepwise progression of B lineage differentiation supported by interleukin 7 and other stromal cell molecules.
The Journal of experimental medicine 1990;171(5):1683-95.
1990: N Nojima; Makoto Kobayashi; M Shionome; Naoyuki Takahashi; Toshio Suda; Kohji Hasegawa
Fibroblastic cells derived from bovine periodontal ligaments have the phenotypes of osteoblasts.
Journal of periodontal research 1990;25(3):179-85.
1990: C H Jin; Chisato Miyaura; Hiromichi Tanaka; J Takito; E Abe; Toshio Suda
Fusion of mouse alveolar macrophages induced by 1 alpha,25-dihydroxyvitamin D3 involves extracellular, but not intracellular, calcium.
Journal of cellular physiology 1990;142(2):434-9.
1990: H Ozawa; K Imamura; E Abe; Naoyuki Takahashi; T Hiraide; Yoshinobu Shibasaki; T Fukuhara; Toshio Suda
Effect of a continuously applied compressive pressure on mouse osteoblast-like cells (MC3T3-E1) in vitro.
Journal of cellular physiology 1990;142(1):177-85.
1990: J Takito; Toshimasa Shinki; Takahisa Sasaki; Toshio Suda
Calcium uptake by brush-border and basolateral membrane vesicles in chick duodenum.
The American journal of physiology 1990;258(1 Pt 1):G16-23.
1989: Nobuyuki Udagawa; Naoyuki Takahashi; T Akatsu; Takahisa Sasaki; A Yamaguchi; H Kodama; T J Martin; Toshio Suda
The bone marrow-derived stromal cell lines MC3T3-G2/PA6 and ST2 support osteoclast-like cell differentiation in cocultures with mouse spleen cells.
Endocrinology 1989;125(4):1805-13.
1989: Toshimasa Shinki; Toshio Suda
Purification and characterization of spermidine N1-acetyltransferase from chick duodenum.
European journal of biochemistry / FEBS 1989;183(2):285-90.
1989: Takahisa Sasaki; Naoyuki Takahashi; S Higashi; Toshio Suda
Multinucleated cells formed on calcified dentine from mouse bone marrow cells treated with 1 alpha,25-dihydroxyvitamin D3 have ruffled borders and resorb dentine.
The Anatomical record 1989;224(3):379-91.
1989: Toshio Suda
The role of 1 alpha,25-dihydroxyvitamin D3 in the myeloid cell differentiation.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1989;191(3):214-20.
1989: T Akatsu; Naoyuki Takahashi; Nobuyuki Udagawa; K Sato; N Nagata; J M Moseley; T J Martin; Toshio Suda
Parathyroid hormone (PTH)-related protein is a potent stimulator of osteoclast-like multinucleated cell formation to the same extent as PTH in mouse marrow cultures.
Endocrinology 1989;125(1):20-7.
1989: Toshimasa Shinki; Hiromichi Tanaka; Tsuyoki Kadofuku; T Sato; Toshio Suda
Major pathway for putrescine synthesis induced by 1 alpha,25-dihydroxyvitamin D3 in chick duodenum.
Gastroenterology 1989;96(6):1494-501.
1989: H Ozawa; E Abe; Yoshinobu Shibasaki; T Fukuhara; Toshio Suda
Electric fields stimulate DNA synthesis of mouse osteoblast-like cells (MC3T3-E1) by a mechanism involving calcium ions.
Journal of cellular physiology 1989;138(3):477-83.
1989: Chisato Miyaura; C H Jin; Y Yamaguchi; M Tomida; M Hozumi; T Matsuda; T Hirano; T Kishimoto; Toshio Suda
Production of interleukin 6 and its relation to the macrophage differentiation of mouse myeloid leukemia cells (M1) treated with differentiation-inducing factor and 1 alpha,25-dihydroxyvitamin D3.
Biochemical and biophysical research communications 1989;158(3):660-6.
1989: T Akatsu; Naoyuki Takahashi; Kazuhiro Debari; I Morita; S Murota; N Nagata; O Takatani; Toshio Suda
Prostaglandins promote osteoclastlike cell formation by a mechanism involving cyclic adenosine 3',5'-monophosphate in mouse bone marrow cell cultures.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1989;4(1):29-35.
1989: S I Nishikawa; Shin-Ichi Hayashi; M Ogawa; T Kunisada; S Nishikawa; T Sudo; H Nakauchi; Toshio Suda
Control of cell growth and differentiation during early B-cell development by stromal cell molecules.
Cold Spring Harbor symposia on quantitative biology 1989;54 Pt 1():171-4.
1989: Hiromichi Tanaka; Toshimasa Shinki; T Hayashi; C H Jin; Chisato Miyaura; E Abe; Toshio Suda
Spermidine-dependent proteins are involved in the fusion of mouse alveolar macrophages induced by 1 alpha,25-dihydroxyvitamin D3 and interleukin 4.
Experimental cell research 1989;180(1):72-83.
1988: E Abe; Y Ishimi; Naoyuki Takahashi; T Akatsu; H Ozawa; H Yamana; S Yoshiki; Toshio Suda
A differentiation-inducing factor produced by the osteoblastic cell line MC3T3-E1 stimulates bone resorption by promoting osteoclast formation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1988;3(6):635-45.
1988: Naoyuki Takahashi; T Akatsu; Nobuyuki Udagawa; Takahisa Sasaki; A Yamaguchi; J M Moseley; T J Martin; Toshio Suda
Osteoblastic cells are involved in osteoclast formation.
Endocrinology 1988;123(5):2600-2.
1988: C H Jin; A Segawa; Chisato Miyaura; Hiromichi Tanaka; E Abe; Toshio Suda
Calcium is essential in the fusion of mouse alveolar macrophages induced by 1 alpha,25-dihydroxyvitamin D3.
Journal of cellular physiology 1988;137(1):110-6.
1988: Naoyuki Takahashi; T Akatsu; Takahisa Sasaki; G C Nicholson; J M Moseley; T J Martin; Toshio Suda
Induction of calcitonin receptors by 1 alpha, 25-dihydroxyvitamin D3 in osteoclast-like multinucleated cells formed from mouse bone marrow cells.
Endocrinology 1988;123(3):1504-10.
1988: Chisato Miyaura; K Onozaki; Y Akiyama; T Taniyama; Tsutomu Hirano; T Kishimoto; Toshio Suda
Recombinant human interleukin 6 (B-cell stimulatory factor 2) is a potent inducer of differentiation of mouse myeloid leukemia cells (M1).
FEBS letters 1988;234(1):17-21.
1988: Naoyuki Takahashi; H Yamana; S Yoshiki; David G Roodman; G R Mundy; S J Jones; A Boyde; Toshio Suda
Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow cultures.
Endocrinology 1988;122(4):1373-82.
1987: S Ejiri; A Segawa; Chisato Miyaura; E Abe; Toshio Suda; H Ozawa
An ultrastructural study on the multinucleation process of mouse alveolar macrophages induced by 1 alpha,25-dihydroxyvitamin D3.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1987;2(6):547-57.
1987: E Abe; Y Ishimi; H Tanaka; Chisato Miyaura; H Nagasawa; T Hayashi; Toshio Suda
The relationship between fusion and proliferation in mouse alveolar macrophages.
Endocrinology 1987;121(1):271-7.
1986: Toshimasa Shinki; Tsuyoki Kadofuku; T Sato; Toshio Suda
Spermidine N1-acetyltransferase has a larger role than ornithine decarboxylase in 1 alpha,25-dihydroxyvitamin D3-induced putrescine synthesis.
The Journal of biological chemistry 1986;261(25):11712-6.
1986: Chisato Miyaura; A Segawa; H Nagasawa; E Abe; Toshio Suda
Effects of retinoic acid on the activation and fusion of mouse alveolar macrophages induced by 1 alpha,25-dihydroxyvitamin D3.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1986;1(4):359-68.
1986: E Abe; H Tanaka; Y Ishimi; Chisato Miyaura; T Hayashi; H Nagasawa; M Tomida; Y Yamaguchi; M Hozumi; Toshio Suda
Differentiation-inducing factor purified from conditioned medium of mitogen-treated spleen cell cultures stimulates bone resorption.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(16):5958-62.
1986: T Hayashi; Toshimasa Shinki; Hiromichi Tanaka; E Abe; Toshio Suda
Polyamines are involved in the 1-alpha,25-dihydroxyvitamin D3-induced fusion of mouse alveolar macrophages.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1986;1(2):235-42.
1985: Toshimasa Shinki; N Takahashi; Tsuyoki Kadofuku; T Sato; Toshio Suda
Induction of spermidine N1-acetyltransferase by 1 alpha,25-dihydroxyvitamin D3 as an early common event in the target tissues of vitamin D.
The Journal of biological chemistry 1985;260(4):2185-90.