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Thomas Südhof

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Csaba Földy; Robert C Malenka; Thomas C Südhof
Autism-associated neuroligin-3 mutations commonly disrupt tonic endocannabinoid signaling.
Wei Xu; Thomas C Südhof
A neural circuit for memory specificity and generalization.
Sandra Jurado; Alfredo J Miñano Molina; Thomas C Südhof; Yingsha Zhang; Debanjan Goswami; Robert C Malenka
LTP requires a unique postsynaptic SNARE fusion machinery.

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All Publications

2013: Csaba Földy; Robert C Malenka; Thomas C Südhof
Autism-associated neuroligin-3 mutations commonly disrupt tonic endocannabinoid signaling.
Neuron 2013;78(3):498-509.
2013: Wei Xu; Thomas C Südhof
A neural circuit for memory specificity and generalization.
Science (New York, N.Y.) 2013;339(6125):1290-5.
2013: Sandra Jurado; Alfredo J Miñano Molina; Thomas C Südhof; Yingsha Zhang; Debanjan Goswami; Robert C Malenka
LTP requires a unique postsynaptic SNARE fusion machinery.
Neuron 2013;77(3):542-58.
2013: Peng Cao; Xiaofei Yang; Thomas C Südhof
Complexin activates exocytosis of distinct secretory vesicles controlled by different synaptotagmins.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013;33(4):1714-27.
2013: Peng Zhou; Xiaofei Yang; Yingsha Zhang; Taulant Bacaj; Zhiping Pang; christian rosenmund; Thomas C Südhof
Syntaxin-1 N-peptide and Habc-domain perform distinct essential functions in synaptic vesicle fusion.
The EMBO journal 2013;32(1):159-71.
2013: Kangduk Lee; Sung-Jin Lee; Yuan Qiang; Thomas C Südhof; H Shawn Je; Hyun Kim; Yoonji Kim; Dongmin Lee; Hyun Woo Lee; Jaewon Ko
MDGAs interact selectively with neuroligin-2 but not other neuroligins to regulate inhibitory synapse development.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(1):336-41.
2013: Jiajie Diao; Minjoung Kyoung; Manu Sharma; Thomas C Südhof; Sandro Vivona; Jacqueline Burré; Daniel J Cipriano; Axel T Brunger
Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2.
eLife 2013;2():e00592.
2012: Garret R Anderson; Jason Aoto; Timothy Galfin; Robert C Malenka; Wei Xu; Thomas C Südhof
Candidate autism gene screen identifies critical role for cell-adhesion molecule CASPR2 in dendritic arborization and spine development.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(44):18120-5.
2012: Jacqueline Burré; Manu Sharma; Thomas C Südhof
Systematic mutagenesis of α-synuclein reveals distinct sequence requirements for physiological and pathological activities.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(43):15227-42.
2012: Manu Sharma; Jacqueline Burré; Thomas C Südhof
Proteasome inhibition alleviates SNARE-dependent neurodegeneration.
Science translational medicine 2012;4(147):147ra113.
2012: Shao-Nian Yang; Jia Yu; Lina Yu; Taulant Bacaj; Yuxin Li; Yue Shi; Ok-Ho Shin; Thomas C Südhof; Guang Yang; Per-Olof Berggren
Inositol hexakisphosphate suppresses excitatory neurotransmission via synaptotagmin-1 C2B domain in the hippocampal neuron.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(30):12183-8.
2012: Pascal S Kaeser; Lunbin Deng; Mingming Fan; Thomas C Südhof
RIM genes differentially contribute to organizing presynaptic release sites.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(29):11830-5.
2012: Thomas C Südhof
The presynaptic active zone.
Neuron 2012;75(1):11-25.
2012: Nicolas Narboux-Nême; Nicole Ropert; Jean Rossier; Thomas C Südhof; Reha S Erzurumlu; Alexis Evrard; Isabelle Ferezou; Pascal S Kaeser; Jeanne Lainé; patricia Gaspar
Neurotransmitter release at the thalamocortical synapse instructs barrel formation but not axon patterning in the somatosensory cortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(18):6183-96.
2012: Morgan Sheng; Bernardo L Sabatini; Thomas C Südhof
Synapses and Alzheimer's disease.
Cold Spring Harbor perspectives in biology 2012;4(5):.
2012: Markus Missler; Thomas C Südhof; Thomas Biederer
Synaptic cell adhesion.
Cold Spring Harbor perspectives in biology 2012;4(4):a005694.
2012: Demet Araç; Marc F Bolliger; Antony A Boucard; Jenna Nguyen; S Michael Soltis; Thomas C Südhof; Axel T Brunger
A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis.
The EMBO journal 2012;31(6):1364-78.
2012: Antony A Boucard; Jaewon Ko; Thomas C Südhof
High affinity neurexin binding to cell adhesion G-protein-coupled receptor CIRL1/latrophilin-1 produces an intercellular adhesion complex.
The Journal of biological chemistry 2012;287(12):9399-413.
2012: Wei Xu; Paul S Buckmaster; Robert C Malenka; Wade Morishita; Zhiping Pang; Thomas C Südhof
Distinct neuronal coding schemes in memory revealed by selective erasure of fast synchronous synaptic transmission.
Neuron 2012;73(5):990-1001.
2012: M E Haws; D L Jarvis; P S Kaeser; Thomas C Südhof; Craig M Powell
Region-specific deletions of RIM1 reproduce a subset of global RIM1α(-/-) phenotypes.
Genes, brain, and behavior 2012;11(2):201-13.
2012: Yea Jin Kaeser-Woo; Xiaofei Yang; Thomas C Südhof
C-terminal complexin sequence is selectively required for clamping and priming but not for Ca2+ triggering of synaptic exocytosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(8):2877-85.
2012: Manu Sharma; Peter Bronk; Jacqueline Burré; Wei Xu; Yingsha Zhang; Thomas C Südhof
CSPα knockout causes neurodegeneration by impairing SNAP-25 function.
The EMBO journal 2012;31(4):829-41.
2012: Ernesto Lujan; Thomas C Südhof; Henrik Ahlenius; Soham Chanda; Marius Wernig
Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(7):2527-32.
2012: Mohiuddin Ahmad; Debanjan Goswami; Yea Jin Kaeser-Woo; Jai S Polepalli; Thomas C Südhof; Xiaofei Yang; Robert C Malenka
Postsynaptic complexin controls AMPA receptor exocytosis during LTP.
Neuron 2012;73(2):260-7.
2012: Josep Rizo; Thomas C Südhof
The membrane fusion enigma: SNAREs, Sec1/Munc18 proteins, and their accomplices--guilty as charged?
Annual review of cell and developmental biology 2012;28():279-308.
2011: Nan Yang; Yi Han Ng; Zhiping Pang; Thomas C Südhof; Marius Wernig
Induced neuronal cells: how to make and define a neuron.
Cell stem cell 2011;9(6):517-25.
2011: Thomas C Südhof; Josep Rizo
Synaptic vesicle exocytosis.
Cold Spring Harbor perspectives in biology 2011;3(12):.
2011: Samuele Marro; Zhiping Pang; Kun Qu; Thomas C Südhof; Miao-Chih Tsai; Howard Y Chang; Nan Yang; Marius Wernig
Direct lineage conversion of terminally differentiated hepatocytes to functional neurons.
Cell stem cell 2011;9(4):374-82.
2011: Gilberto J Soler-Llavina; Thomas C Südhof; Marc V Fuccillo; Jaewon Ko; Robert C Malenka
The neurexin ligands, neuroligins and leucine-rich repeat transmembrane proteins, perform convergent and divergent synaptic functions in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(40):16502-9.
2011: Theodoros Tsetsenis; Thomas J Younts; Pablo E Castillo; Chiayu Q Chiu; Pascal S Kaeser; Thomas C Südhof
Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(34):14300-5.
2011: Mark Etherton; Csaba Földy; Xinran Liu; Robert C Malenka; Mehrdad Shamloo; Manu Sharma; Katsuhiko Tabuchi; Thomas C Südhof
Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(33):13764-9.
2011: Zhiping Pang; Vittorio Sebastiano; Thomas C Südhof; Thomas Vierbuchen; Ami Citri; Daniel R Fuentes; Samuele Marro; Austin Ostermeier; Nan Yang; Troy Q Yang; Marius Wernig
Induction of human neuronal cells by defined transcription factors.
Nature 2011;476(7359):220-3.
2011: Jaewon Ko; Robert C Malenka; Gilberto J Soler-Llavina; Marc V Fuccillo; Thomas C Südhof
Neuroligins/LRRTMs prevent activity- and Ca2+/calmodulin-dependent synapse elimination in cultured neurons.
The Journal of cell biology 2011;194(2):323-34.
2011: Mark R Etherton; Jaewon Ko; Manu Sharma; Katsuhiko Tabuchi; Thomas C Südhof
An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus.
The EMBO journal 2011;30(14):2908-19.
2011: Zhiping Pang; Taulant Bacaj; Xiaofei Yang; Peng Zhou; Wei Xu; Thomas C Südhof
Doc2 supports spontaneous synaptic transmission by a Ca(2+)-independent mechanism.
Neuron 2011;70(2):244-51.
2011: Peng Cao; Anton Maximov; Thomas C Südhof
Activity-dependent IGF-1 exocytosis is controlled by the Ca(2+)-sensor synaptotagmin-10.
Cell 2011;145(2):300-11.
2011: David C Martinelli; Thomas C Südhof
Cerebellins meet neurexins (Commentary on Matsuda & Yuzaki).
The European journal of neuroscience 2011;33(8):1445-6.
2011: Marc F Bolliger; David C Martinelli; Thomas C Südhof
The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(6):2534-9.
2011: N Gustavsson; T Seah; Y Lao; George K Radda; Thomas C Südhof; W Han
Delayed onset of hyperglycaemia in a mouse model with impaired glucagon secretion demonstrates that dysregulated glucagon secretion promotes hyperglycaemia and type 2 diabetes.
Diabetologia 2011;54(2):415-22.
2011: Lunbin Deng; Pascal S Kaeser; Wei Xu; Thomas C Südhof
RIM proteins activate vesicle priming by reversing autoinhibitory homodimerization of Munc13.
Neuron 2011;69(2):317-31.
2011: Yunyun Han; Pascal S Kaeser; Thomas C Südhof; Ralf Schneggenburger
RIM determines Ca²+ channel density and vesicle docking at the presynaptic active zone.
Neuron 2011;69(2):304-16.
2011: Pascal S Kaeser; Lunbin Deng; Yun Wang; Irina Dulubova; Xinran Liu; Josep Rizo; Thomas C Südhof
RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction.
Cell 2011;144(2):282-95.
2011: Manu Sharma; Jacqueline Burré; Thomas C Südhof
CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity.
Nature cell biology 2011;13(1):30-9.
2010: Taulant Bacaj; Zhiping Pang; Thomas C Südhof
Testing the SNARE/SM protein model of membrane fusion.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(52):22365-6.
2010: Xiaofei Yang; Yea Jin Kaeser-Woo; Zhiping Pang; Wei Xu; Thomas C Südhof
Complexin clamps asynchronous release by blocking a secondary Ca(2+) sensor via its accessory α helix.
Neuron 2010;68(5):907-20.
2010: Elissa M Robbins; Alexander J Krupp; Karen Perez de Arce; Ananda K Ghosh; Adam I Fogel; Antony Boucard; Thomas C Südhof; Valentin Stein; Thomas Biederer
SynCAM 1 adhesion dynamically regulates synapse number and impacts plasticity and learning.
Neuron 2010;68(5):894-906.
2010: Dawei Zhang; Chen Zhang; Angela Ho; Alfredo Kirkwood; Thomas C Südhof; Jie Shen
Inactivation of presenilins causes pre-synaptic impairment prior to post-synaptic dysfunction.
Journal of neurochemistry 2010;115(5):1215-21.
2010: Margarita Segovia; Eva Alés; María Angeles Montes; Imelda Bonifas; Imane Jemal; Manfred Lindau; Anton Maximov; Thomas C Südhof; Guillermo Alvarez de Toledo
Push-and-pull regulation of the fusion pore by synaptotagmin-7.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(44):19032-7.
2010: Jean-Sébastien SCHONN; Jan R T van Weering; Ralf Mohrmann; Oliver M Schlüter; Thomas C Südhof; Heidi de Wit; Matthijs Verhage; Jakob B Sørensen
Rab3 proteins involved in vesicle biogenesis and priming in embryonic mouse chromaffin cells.
Traffic (Copenhagen, Denmark) 2010;11(11):1415-28.
2010: Zhiping Pang; Wei Xu; Peng Cao; Thomas C Südhof
Calmodulin suppresses synaptotagmin-2 transcription in cortical neurons.
The Journal of biological chemistry 2010;285(44):33930-9.
2010: Hongmei Li; Baiping Wang; Zilai Wang; Qinxi Guo; Katsuhiko Tabuchi; Robert E Hammer; Thomas C Südhof; Hui Zheng
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(40):17362-7.
2010: Hongmei Li; Zilai Wang; Baiping Wang; Qinxi Guo; Georgia Dolios; Katsuhiko Tabuchi; Robert E Hammer; Thomas C Südhof; Rong Wang; Hui Zheng
Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis.
The Journal of biological chemistry 2010;285(40):30598-605.
2010: Jacqueline Burré; Manu Sharma; Theodoros Tsetsenis; Vladimir Buchman; Mark R Etherton; Thomas C Südhof
Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro.
Science (New York, N.Y.) 2010;329(5999):1663-7.
2010: Zhiping Pang; Thomas C Südhof
Cell biology of Ca2+-triggered exocytosis.
Current opinion in cell biology 2010;22(4):496-505.
2010: Chen Zhang; Deniz Atasoy; Demet Araç; Xiaofei Yang; Marc V Fucillo; Alfred J Robison; Jaewon Ko; Axel T Brunger; Thomas C Südhof
Neurexins physically and functionally interact with GABA(A) receptors.
Neuron 2010;66(3):403-16.
2010: Jacqueline Blundell; Pascal S Kaeser; Thomas C Südhof; Craig M Powell
RIM1alpha and interacting proteins involved in presynaptic plasticity mediate prepulse inhibition and additional behaviors linked to schizophrenia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(15):5326-33.
2010: Konark Mukherjee; Xiaofei Yang; Stefan H Gerber; Hyung-Bae Kwon; Angela Ho; Pablo E Castillo; Xinran Liu; Thomas C Südhof
Piccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosis.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(14):6504-9.
2010: Zhiping Pang; Peng Cao; Wei Xu; Thomas C Südhof
Calmodulin controls synaptic strength via presynaptic activation of calmodulin kinase II.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(11):4132-42.
2010: Ok-Ho Shin; Jun Lu; Jeong-Seop Rhee; Diana R Tomchick; Zhiping Pang; Sonja M Wojcik; Marcial Camacho-Perez; Nils Brose; Mischa Machius; Josep Rizo; christian rosenmund; Thomas C Südhof
Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis.
Nature structural & molecular biology 2010;17(3):280-8.
2010: Thomas Vierbuchen; Austin Ostermeier; Zhiping Pang; Yuko Kokubu; Thomas C Südhof; Marius Wernig
Direct conversion of fibroblasts to functional neurons by defined factors.
Nature 2010;463(7284):1035-41.
2010: Jacqueline Blundell; Cory A Blaiss; Mark R Etherton; Felipe Espinosa; Katsuhiko Tabuchi; Christopher Walz; Marc F Bolliger; Thomas C Südhof; Craig M Powell
Neuroligin-1 deletion results in impaired spatial memory and increased repetitive behavior.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(6):2115-29.
2010: Natalia Gustavsson; Xiaorui Wang; Yue Wang; Tingting Seah; Jun Xu; George K Radda; Thomas C Südhof; Weiping Han
Neuronal calcium sensor synaptotagmin-9 is not involved in the regulation of glucose homeostasis or insulin secretion.
PloS one 2010;5(11):e15414.
2010: Mingshan Xue; Timothy K Craig; Ok-Ho Shin; Liyi Li; Chad A Brautigam; Diana R Tomchick; Thomas C Südhof; christian rosenmund; Josep Rizo
Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7.
PloS one 2010;5(9):.
2010: Konark Mukherjee; Manu Sharma; Reinhard Jahn; Markus C Wahl; Thomas C Südhof
Evolution of CASK into a Mg2+-sensitive kinase.
Science signaling 2010;3(119):ra33.
2009: Jaewon Ko; Marc V Fuccillo; Robert C Malenka; Thomas C Südhof
LRRTM2 functions as a neurexin ligand in promoting excitatory synapse formation.
Neuron 2009;64(6):791-8.
2009: Jay R Gibson; Kimberly M Huber; Thomas C Südhof
Neuroligin-2 deletion selectively decreases inhibitory synaptic transmission originating from fast-spiking but not from somatostatin-positive interneurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(44):13883-97.
2009: Pascal S Kaeser; Lunbin Deng; Andrés Chávez; Xinran Liu; Pablo E Castillo; Thomas C Südhof
ELKS2alpha/CAST deletion selectively increases neurotransmitter release at inhibitory synapses.
Neuron 2009;64(2):227-39.
2009: Jaewon Ko; Chen Zhang; Demet Arac; Antony A Boucard; Axel T Brunger; Thomas C Südhof
Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation.
The EMBO journal 2009;28(20):3244-55.
2009: Mark R Etherton; Cory A Blaiss; Craig M Powell; Thomas C Südhof
Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(42):17998-8003.
2009: Ok-Ho Shin; Jun Xu; Josep Rizo; Thomas C Südhof
Differential but convergent functions of Ca2+ binding to synaptotagmin-1 C2 domains mediate neurotransmitter release.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(38):16469-74.
2009: Chen Zhang; Jeff M Milunsky; Stephanie Newton; Jaewon Ko; Geping Zhao; Thomas Maher; Helen Tager-Flusberg; Marc F Bolliger; Alice S Carter; Antony A Boucard; Craig M Powell; Thomas C Südhof
A neuroligin-4 missense mutation associated with autism impairs neuroligin-4 folding and endoplasmic reticulum export.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(35):10843-54.
2009: Chen Zhang; Bei Wu; Vassilios Beglopoulos; Mary Wines-Samuelson; Dawei Zhang; Ioannis Dragatsis; Thomas C Südhof; Jie Shen
Presenilins are essential for regulating neurotransmitter release.
Nature 2009;460(7255):632-6.
2009: Ferenc Deák; Xinran Liu; Mikhail Khvotchev; Gang Li; Ege T Kavalali; Shuzo Sugita; Thomas C Südhof
Alpha-latrotoxin stimulates a novel pathway of Ca2+-dependent synaptic exocytosis independent of the classical synaptic fusion machinery.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(27):8639-48.
2009: Katsuhiko Tabuchi; Guiquan Chen; Thomas C Südhof; Jie Shen
Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(22):7290-301.
2009: Nadine Gogolla; Jocelyn J Leblanc; Kathleen B Quast; Thomas C Südhof; Michela Fagiolini; Takao K Hensch
Common circuit defect of excitatory-inhibitory balance in mouse models of autism.
Journal of neurodevelopmental disorders 2009;1(2):172-81.
2009: Jun Xu; Zhiping Pang; Ok-Ho Shin; Thomas C Südhof
Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous release.
Nature neuroscience 2009;12(6):759-66.
2009: Natalia Gustavsson; Shun-Hui Wei; Dong Nhut Hoang; Ye Lao; Quan Zhang; George K Radda; Patrik Rorsman; Thomas C Südhof; Weiping Han
Synaptotagmin-7 is a principal Ca2+ sensor for Ca2+ -induced glucagon exocytosis in pancreas.
The Journal of physiology 2009;587(Pt 6):1169-78.
2009: Ferenc Deák; Yi Xu; Wen-Pin Chang; Irina Dulubova; Mikhail Khvotchev; Xinran Liu; Thomas C Südhof; Josep Rizo
Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming.
The Journal of cell biology 2009;184(5):751-64.
2009: Jacqueline Blundell; Katsuhiko Tabuchi; M F Bolliger; C A Blaiss; Nils Brose; Xinran Liu; Thomas C Südhof; Craig M Powell
Increased anxiety-like behavior in mice lacking the inhibitory synapse cell adhesion molecule neuroligin 2.
Genes, brain, and behavior 2009;8(1):114-26.
2009: Wen-Pin Chang; Thomas C Südhof
SV2 renders primed synaptic vesicles competent for Ca2+ -induced exocytosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(4):883-97.
2009: Anton Maximov; Jiong Tang; Xiaofei Yang; Zhiping Pang; Thomas C Südhof
Complexin controls the force transfer from SNARE complexes to membranes in fusion.
Science (New York, N.Y.) 2009;323(5913):516-21.
2009: Thomas C Südhof; James E Rothman
Membrane fusion: grappling with SNARE and SM proteins.
Science (New York, N.Y.) 2009;323(5913):474-7.
2008: Angela Ho; Xinran Liu; Thomas C Südhof
Deletion of Mint proteins decreases amyloid production in transgenic mouse models of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(53):14392-400.
2008: Thomas C Südhof; Robert C Malenka
Understanding synapses: past, present, and future.
Neuron 2008;60(3):469-76.
2008: Thomas C Südhof
Neuroligins and neurexins link synaptic function to cognitive disease.
Nature 2008;455(7215):903-11.
2008: Pascal S Kaeser; Hyung-Bae Kwon; Jacqueline Blundell; Vivien Chevaleyre; Wade Morishita; Robert C Malenka; Craig M Powell; Pablo E Castillo; Thomas C Südhof
RIM1alpha phosphorylation at serine-413 by protein kinase A is not required for presynaptic long-term plasticity or learning.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(38):14680-5.
2008: Stefan H Gerber; Jong-Cheol Rah; sang-won min; Xinran Liu; Heidi de Wit; Irina Dulubova; Alexander C Meyer; Josep Rizo; Marife Arancillo; Robert E Hammer; Matthijs Verhage; christian rosenmund; Thomas C Südhof
Conformational switch of syntaxin-1 controls synaptic vesicle fusion.
Science (New York, N.Y.) 2008;321(5895):1507-10.
2008: Marc F Bolliger; Jimin Pei; Stephan Maxeiner; Antony A Boucard; Nick V Grishin; Thomas C Südhof
Unusually rapid evolution of Neuroligin-4 in mice.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(17):6421-6.
2008: Konark Mukherjee; Manu Sharma; Henning Urlaub; Gleb P Bourenkov; Reinhard Jahn; Thomas C Südhof; Markus C Wahl
CASK Functions as a Mg2+-independent neurexin kinase.
Cell 2008;133(2):328-39.
2008: Natalia Gustavsson; Ye Lao; Anton Maximov; Jen-Chieh Chuang; Elena Kostromina; Joyce J Repa; Cai Li; George K Radda; Thomas C Südhof; Weiping Han
Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(10):3992-7.
2008: Anton Maximov; Ye Lao; Hongmei Li; Xiaocheng Chen; Josep Rizo; Jakob B Sørensen; Thomas C Südhof
Genetic analysis of synaptotagmin-7 function in synaptic vesicle exocytosis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(10):3986-91.
2008: Jean-Sébastien SCHONN; Anton Maximov; Ye Lao; Thomas C Südhof; Jakob B Sørensen
Synaptotagmin-1 and -7 are functionally overlapping Ca2+ sensors for exocytosis in adrenal chromaffin cells.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(10):3998-4003.
2008: Gilbert Gallardo; Oliver M Schlüter; Thomas C Südhof
A molecular pathway of neurodegeneration linking alpha-synuclein to ApoE and Abeta peptides.
Nature neuroscience 2008;11(3):301-8.
2007: Demet Araç; Antony A Boucard; Engin Ozkan; Pavel Strop; Evan W. Newell; Thomas C Südhof; Axel T Brunger
Structures of neuroligin-1 and the neuroligin-1/neurexin-1 beta complex reveal specific protein-protein and protein-Ca2+ interactions.
Neuron 2007;56(6):992-1003.
2007: Jianyuan Sun; Zhiping Pang; Dengkui Qin; Abigail T Fahim; Roberto Adachi; Thomas C Südhof
A dual-Ca2+-sensor model for neurotransmitter release in a central synapse.
Nature 2007;450(7170):676-82.
2007: Mikhail Khvotchev; Irina Dulubova; Jianyuan Sun; Han Dai; Josep Rizo; Thomas C Südhof
Dual modes of Munc18-1/SNARE interactions are coupled by functionally critical binding to syntaxin-1 N terminus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(45):12147-55.
2007: Katsuhiko Tabuchi; Jacqueline Blundell; Mark R Etherton; Robert E Hammer; Xinran Liu; Craig M Powell; Thomas C Südhof
A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice.
Science (New York, N.Y.) 2007;318(5847):71-6.
2007: Thomas C Südhof
Membrane fusion as a team effort.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(34):13541-2.
2007: Hao Wu; Jun Xu; Zhiping Pang; Weihong Ge; Kevin J Kim; Bruno Blanchi; Caifu Chen; Thomas C Südhof; Yi E Sun
Integrative genomic and functional analyses reveal neuronal subtype differentiation bias in human embryonic stem cell lines.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(34):13821-6.
2007: Rong Guan; Han Dai; Diana R Tomchick; Irina Dulubova; Mischa Machius; Thomas C Südhof; Josep Rizo
Crystal structure of the RIM1alpha C2B domain at 1.7 A resolution.
Biochemistry 2007;46(31):8988-98.
2007: Peter Bronk; Ferenc Deák; Michael Wilson; Xinran Liu; Thomas C Südhof; Ege T Kavalali
Differential effects of SNAP-25 deletion on Ca2+ -dependent and Ca2+ -independent neurotransmission.
Journal of neurophysiology 2007;98(2):794-806.
2007: Alexander A Chubykin; Deniz Atasoy; Mark R Etherton; Nils Brose; Ege T Kavalali; Jay R Gibson; Thomas C Südhof
Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2.
Neuron 2007;54(6):919-31.
2007: Vivien Chevaleyre; Boris D Heifets; Pascal S Kaeser; Thomas C Südhof; Dominick P Purpura; Pablo E Castillo
Endocannabinoid-mediated long-term plasticity requires cAMP/PKA signaling and RIM1alpha.
Neuron 2007;54(5):801-12.
2007: Jun Xu; Tomoyuki Mashimo; Thomas C Südhof
Synaptotagmin-1, -2, and -9: Ca(2+) sensors for fast release that specify distinct presynaptic properties in subsets of neurons.
Neuron 2007;54(4):567-81.
2007: Irina Dudanova; Katsuhiko Tabuchi; Astrid Rohlmann; Thomas C Südhof; Markus Missler
Deletion of alpha-neurexins does not cause a major impairment of axonal pathfinding or synapse formation.
The Journal of comparative neurology 2007;502(2):261-74.
2007: Anton Maximov; Zhiping Pang; Dougal G R Tervo; Thomas C Südhof
Monitoring synaptic transmission in primary neuronal cultures using local extracellular stimulation.
Journal of neuroscience methods 2007;161(1):75-87.
2007: sang-won min; Wen-Pin Chang; Thomas C Südhof
E-Syts, a family of membranous Ca2+-sensor proteins with multiple C2 domains.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(10):3823-8.
2007: Xavier Nicol; Sylvie Voyatzis; Aude Muzerelle; Nicolas Narboux-Nême; Thomas C Südhof; Richard Miles; patricia Gaspar
cAMP oscillations and retinal activity are permissive for ephrin signaling during the establishment of the retinotopic map.
Nature neuroscience 2007;10(3):340-7.
2007: Irina Dulubova; Mikhail Khvotchev; Siqi Liu; Iryna Huryeva; Thomas C Südhof; Josep Rizo
Munc18-1 binds directly to the neuronal SNARE complex.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(8):2697-702.
2007: Deniz Atasoy; Susanne Schoch; Angela Ho; Krisztina A Nadasy; Xinran Liu; Weiqi Zhang; Konark Mukherjee; Elena D Nosyreva; Rafael Fernandez-Chacon; Markus Missler; Ege T Kavalali; Thomas C Südhof
Deletion of CASK in mice is lethal and impairs synaptic function.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(7):2525-30.
2007: Anton Maximov; Ok-Ho Shin; Xinran Liu; Thomas C Südhof
Synaptotagmin-12, a synaptic vesicle phosphoprotein that modulates spontaneous neurotransmitter release.
The Journal of cell biology 2007;176(1):113-24.
2006: Zhiping Pang; Ernestina Melicoff; Daniel Padgett; Yun Liu; Andrew F Teich; Burton F Dickey; Weichun Lin; Roberto Adachi; Thomas C Südhof
Synaptotagmin-2 is essential for survival and contributes to Ca2+ triggering of neurotransmitter release in central and neuromuscular synapses.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(52):13493-504.
2006: Angela Ho; Wade Morishita; Deniz Atasoy; Xinran Liu; Katsuhiko Tabuchi; Robert E Hammer; Robert C Malenka; Thomas C Südhof
Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(50):13089-101.
2006: Susanne Schoch; Tobias Mittelstaedt; Pascal S Kaeser; Daniel Padgett; Nicole Feldmann; Vivien Chevaleyre; Pablo E Castillo; Robert E Hammer; Weiping Han; Frank Schmitz; Weichun Lin; Thomas C Südhof
Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release.
The EMBO journal 2006;25(24):5852-63.
2006: Judyta Juranek; Konark Mukherjee; Michael Rickmann; Henrik Martens; Jaroslaw Calka; Thomas C Südhof; Reinhard Jahn
Differential expression of active zone proteins in neuromuscular junctions suggests functional diversification.
The European journal of neuroscience 2006;24(11):3043-52.
2006: Zhiping Pang; Ok-Ho Shin; Alexander C Meyer; christian rosenmund; Thomas C Südhof
A gain-of-function mutation in synaptotagmin-1 reveals a critical role of Ca2+-dependent soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex binding in synaptic exocytosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(48):12556-65.
2006: Thomas C Südhof
Synaptic vesicles: an organelle comes of age.
Cell 2006;127(4):671-3.
2006: Davide Comoletti; Robyn E Flynn; Antony A Boucard; Borries Demeler; Virgil Schirf; Jianxin Shi; Lori L Jennings; Helen R Newlin; Thomas C Südhof; Palmer Taylor
Gene selection, alternative splicing, and post-translational processing regulate neuroligin selectivity for beta-neurexins.
Biochemistry 2006;45(42):12816-27.
2006: Jiong Tang; Anton Maximov; Ok-Ho Shin; Han Dai; Josep Rizo; Thomas C Südhof
A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis.
Cell 2006;126(6):1175-87.
2006: Frederique Varoqueaux; Gayane Aramuni; Randi L Rawson; Ralf Mohrmann; Markus Missler; Kurt Gottmann; Weiqi Zhang; Thomas C Südhof; Nils Brose
Neuroligins determine synapse maturation and function.
Neuron 2006;51(6):741-54.
2006: Lauren R Sheckler; Lisa Henry; Shuzo Sugita; Thomas C Südhof; Gabby Rudenko
Crystal structure of the second LNS/LG domain from neurexin 1alpha: Ca2+ binding and the effects of alternative splicing.
The Journal of biological chemistry 2006;281(32):22896-905.
2006: Jun Lu; Mischa Machius; Irina Dulubova; Han Dai; Thomas C Südhof; Diana R Tomchick; Josep Rizo
Structural basis for a Munc13-1 homodimer to Munc13-1/RIM heterodimer switch.
PLoS biology 2006;4(7):e192.
2006: Ferenc Deák; Ok-Ho Shin; Ege T Kavalali; Thomas C Südhof
Structural determinants of synaptobrevin 2 function in synaptic vesicle fusion.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(25):6668-76.
2006: Ferenc Deák; Ok-Ho Shin; Jiong Tang; Phyllis Hanson; Josep Ubach; Reinhard Jahn; Josep Rizo; Ege T Kavalali; Thomas C Südhof
Rabphilin regulates SNARE-dependent re-priming of synaptic vesicles for fusion.
The EMBO journal 2006;25(12):2856-66.
2006: LiYi Li; Ok-Ho Shin; Jeong-Seop Rhee; Demet Araç; Jong-Cheol Rah; Josep Rizo; Thomas C Südhof; christian rosenmund
Phosphatidylinositol phosphates as co-activators of Ca2+ binding to C2 domains of synaptotagmin 1.
The Journal of biological chemistry 2006;281(23):15845-52.
2006: Zhiping Pang; Jianyuan Sun; Josep Rizo; Anton Maximov; Thomas C Südhof
Genetic analysis of synaptotagmin 2 in spontaneous and Ca2+-triggered neurotransmitter release.
The EMBO journal 2006;25(10):2039-50.
2006: Demet Araç; Xiaocheng Chen; Htet A Khant; Josep Ubach; Steven J Ludtke; Masahide Kikkawa; Arthur E Johnson; Wah Chiu; Thomas C Südhof; Josep Rizo
Close membrane-membrane proximity induced by Ca(2+)-dependent multivalent binding of synaptotagmin-1 to phospholipids.
Nature structural & molecular biology 2006;13(3):209-17.
2006: Jianyuan Sun; Peter Bronk; Xinran Liu; Weiping Han; Thomas C Südhof
Synapsins regulate use-dependent synaptic plasticity in the calyx of Held by a Ca2+/calmodulin-dependent pathway.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(8):2880-5.
2006: Frank Schmitz; Lucia Tabares; Darina Khimich; Nicola Strenzke; Pedro de la Villa-Polo; Manuel Castellano-Muñoz; Anna Bulankina; Tobias Moser; Rafael Fernández-Chacón; Thomas C Südhof
CSPalpha-deficiency causes massive and rapid photoreceptor degeneration.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(8):2926-31.
2006: Oliver M Schlüter; Jayeeta Basu; Thomas C Südhof; christian rosenmund
Rab3 superprimes synaptic vesicles for release: implications for short-term synaptic plasticity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(4):1239-46.
2006: Gábor Nagy; Jun Hee Kim; Zhiping Pang; Ulf Matti; Jens Rettig; Thomas C Südhof; Jakob B Sørensen
Different effects on fast exocytosis induced by synaptotagmin 1 and 2 isoforms and abundance but not by phosphorylation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(2):632-43.
2005: Jeong-Seop Rhee; L Y Li; Ok-Ho Shin; Jong-Cheol Rah; Josep Rizo; Thomas C Südhof; christian rosenmund
Augmenting neurotransmitter release by enhancing the apparent Ca2+ affinity of synaptotagmin 1.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(51):18664-9.
2005: Pascal S Kaeser; Thomas C Südhof
RIM function in short- and long-term synaptic plasticity.
Biochemical Society transactions 2005;33(Pt 6):1345-9.
2005: Anton Maximov; Thomas C Südhof
Autonomous function of synaptotagmin 1 in triggering synchronous release independent of asynchronous release.
Neuron 2005;48(4):547-54.
2005: Sreeganga Chandra; Gilbert Gallardo; Rafael Fernández-Chacón; Oliver M Schlüter; Thomas C Südhof
Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration.
Cell 2005;123(3):383-96.
2005: Antony A Boucard; Alexander A Chubykin; Davide Comoletti; Palmer Taylor; Thomas C Südhof
A splice code for trans-synaptic cell adhesion mediated by binding of neuroligin 1 to alpha- and beta-neurexins.
Neuron 2005;48(2):229-36.
2005: Han Dai; Diana R Tomchick; Jesús García; Thomas C Südhof; Mischa Machius; Josep Rizo
Crystal structure of the RIM2 C2A-domain at 1.4 A resolution.
Biochemistry 2005;44(41):13533-42.
2005: Jun Lu; Hongmei Li; Yun Wang; Thomas C Südhof; Josep Rizo
Solution structure of the RIM1alpha PDZ domain in complex with an ELKS1b C-terminal peptide.
Journal of molecular biology 2005;352(2):455-66.
2005: Irina Dulubova; Xuelin Lou; Jun Lu; Iryna Huryeva; Amer Alam; Ralf Schneggenburger; Thomas C Südhof; Josep Rizo
A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?
The EMBO journal 2005;24(16):2839-50.
2005: Sanjiv Shah; Sheu-Fen Lee; Katsuhiko Tabuchi; Yi-Heng Hao; Cong Yu; Quincey LaPlant; Haydn Ball; Charles E Dann; Thomas C Südhof; Gang G. Yu
Nicastrin functions as a gamma-secretase-substrate receptor.
Cell 2005;122(3):435-47.
2005: Yan-You Huang; Stanislav S Zakharenko; Susanne Schoch; Pascal S Kaeser; Roger Janz; Thomas C Südhof; Steven A Siegelbaum; Eric R Kandel
Genetic evidence for a protein-kinase-A-mediated presynaptic component in NMDA-receptor-dependent forms of long-term synaptic potentiation.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(26):9365-70.
2005: Maria Borisovska; Ying Zhao; Yaroslav Tsytsyura; Nataliya Glyvuk; Shigeo Takamori; Ulf Matti; Jens Rettig; Thomas C Südhof; Dieter Bruns
v-SNAREs control exocytosis of vesicles from priming to fusion.
The EMBO journal 2005;24(12):2114-26.
2005: Alexander A Chubykin; Xinran Liu; Davide Comoletti; Igor Tsigelny; Palmer Taylor; Thomas C Südhof
Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism.
The Journal of biological chemistry 2005;280(23):22365-74.
2005: Ruud F G Toonen; Klaas Jan de Vries; Robbert Zalm; Thomas C Südhof; Matthijs Verhage
Munc18-1 stabilizes syntaxin 1, but is not essential for syntaxin 1 targeting and SNARE complex formation.
Journal of neurochemistry 2005;93(6):1393-400.
2005: Weiqi Zhang; Astrid Rohlmann; Vardanush Sargsyan; Gayane Aramuni; Robert E Hammer; Thomas C Südhof; Markus Missler
Extracellular domains of alpha-neurexins participate in regulating synaptic transmission by selectively affecting N- and P/Q-type Ca2+ channels.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(17):4330-42.
2005: Thomas C Südhof
CAPS in search of a lost function.
Neuron 2005;46(1):2-4.
2005: Francesco Fornai; Oliver M Schlüter; Paola Lenzi; Marco Gesi; Riccardo Ruffoli; Michela Ferrucci; Gloria Lazzeri; Carla L Busceti; Fabrizio Pontarelli; Giuseppe Battaglia; Antonio Pellegrini; Ferdinando Nicoletti; Stefano Ruggieri; Antonio Paparelli; Thomas C Südhof
Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(9):3413-8.
2005: Weiping Han; Jeong-Seop Rhee; Anton Maximov; Weichun Lin; Robert E Hammer; christian rosenmund; Thomas C Südhof
C-terminal ECFP fusion impairs synaptotagmin 1 function: crowding out synaptotagmin 1.
The Journal of biological chemistry 2005;280(6):5089-100.
2005: Ok-Ho Shin; Weiping Han; Yun Wang; Thomas C Südhof
Evolutionarily conserved multiple C2 domain proteins with two transmembrane regions (MCTPs) and unusual Ca2+ binding properties.
The Journal of biological chemistry 2005;280(2):1641-51.
2005: Yildirim Sara; Thomas Biederer; Deniz Atasoy; Alexander A Chubykin; Marina G Mozhayeva; Thomas C Südhof; Ege T Kavalali
Selective capability of SynCAM and neuroligin for functional synapse assembly.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(1):260-70.
2004: Mikhail Khvotchev; Thomas C Südhof
Stimulus-dependent dynamic homo- and heteromultimerization of synaptobrevin/VAMP and synaptophysin.
Biochemistry 2004;43(47):15037-43.
2004: Mikhail Khvotchev; Thomas C Südhof
Proteolytic processing of amyloid-beta precursor protein by secretases does not require cell surface transport.
The Journal of biological chemistry 2004;279(45):47101-8.
2004: Ferenc Deák; Susanne Schoch; Xinran Liu; Thomas C Südhof; Ege T Kavalali
Synaptobrevin is essential for fast synaptic-vesicle endocytosis.
Nature cell biology 2004;6(11):1102-8.
2004: Sreeganga Chandra; Francesco Fornai; Hyung-Bae Kwon; Umar Yazdani; Deniz Atasoy; Xinran Liu; Robert E Hammer; Giuseppe Battaglia; Dwight C German; Pablo E Castillo; Thomas C Südhof
Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(41):14966-71.
2004: Han Dai; Ok-Ho Shin; Mischa Machius; Diana R Tomchick; Thomas C Südhof; Josep Rizo
Structural basis for the evolutionary inactivation of Ca2+ binding to synaptotagmin 4.
Nature structural & molecular biology 2004;11(9):844-9.
2004: Irina Dulubova; Angela Ho; Iryna Huryeva; Thomas C Südhof; Josep Rizo
Three-dimensional structure of an independently folded extracellular domain of human amyloid-beta precursor protein.
Biochemistry 2004;43(30):9583-8.
2004: Oliver M Schlüter; Frank Schmitz; Reinhard Jahn; christian rosenmund; Thomas C Südhof
A complete genetic analysis of neuronal Rab3 function.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(29):6629-37.
2004: Nicole Calakos; Susanne Schoch; Thomas C Südhof; Robert C Malenka
Multiple roles for the active zone protein RIM1alpha in late stages of neurotransmitter release.
Neuron 2004;42(6):889-96.
2004: Xinwei Cao; Thomas C Südhof
Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation.
The Journal of biological chemistry 2004;279(23):24601-11.
2004: Rafael Fernández-Chacón; Markus Wölfel; Hiroshi Nishimune; Lucia Tabares; Frank Schmitz; Manuel Castellano-Muñoz; christian rosenmund; Maria L Montesinos; Joshua R Sanes; Ralf Schneggenburger; Thomas C Südhof
The synaptic vesicle protein CSP alpha prevents presynaptic degeneration.
Neuron 2004;42(2):237-51.
2004: Craig M Powell; Susanne Schoch; Lisa M Monteggia; Michel Barrot; Maria F Matos; Nicole Feldmann; Thomas C Südhof; Eric J Nestler
The presynaptic active zone protein RIM1alpha is critical for normal learning and memory.
Neuron 2004;42(1):143-53.
2004: Qiming Li; Thomas C Südhof
Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1.
The Journal of biological chemistry 2004;279(11):10542-50.
2004: Gunnar Kattenstroth; Evangelia Tantalaki; Thomas C Südhof; Kurt Gottmann; Markus Missler
Postsynaptic N-methyl-D-aspartate receptor function requires alpha-neurexins.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(8):2607-12.
2004: Ok-Ho Shin; Anton Maximov; Byung Kook Lim; Josep Rizo; Thomas C Südhof
Unexpected Ca2+-binding properties of synaptotagmin 9.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(8):2554-9.
2004: Angela Ho; Thomas C Südhof
Binding of F-spondin to amyloid-beta precursor protein: a candidate amyloid-beta precursor protein ligand that modulates amyloid-beta precursor protein cleavage.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(8):2548-53.
2004: Weiping Han; Jeong-Seop Rhee; Anton Maximov; Ye Lao; Tomoyuki Mashimo; christian rosenmund; Thomas C Südhof
N-glycosylation is essential for vesicular targeting of synaptotagmin 1.
Neuron 2004;41(1):85-99.
2004: Jesus Garcia; Stefan H Gerber; Shuzo Sugita; Thomas C Südhof; Josep Rizo
A conformational switch in the Piccolo C2A domain regulated by alternative splicing.
Nature structural & molecular biology 2004;11(1):45-53.
2003: Davide Comoletti; Robyn E Flynn; Lori L Jennings; Alexander A Chubykin; Takehito Matsumura; Hana Hasegawa; Thomas C Südhof; Palmer Taylor
Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta.
The Journal of biological chemistry 2003;278(50):50497-505.
2003: Mikhail Khvotchev; Mindong Ren; Shigeo Takamori; Reinhard Jahn; Thomas C Südhof
Divergent functions of neuronal Rab11b in Ca2+-regulated versus constitutive exocytosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(33):10531-9.
2003: Maria F Matos; Konark Mukherjee; Xiaocheng Chen; Josep Rizo; Thomas C Südhof
Evidence for SNARE zippering during Ca2+-triggered exocytosis in PC12 cells.
Neuropharmacology 2003;45(6):777-86.
2003: Tuhin Virmani; Weiping Han; Xinran Liu; Thomas C Südhof; Ege T Kavalali
Synaptotagmin 7 splice variants differentially regulate synaptic vesicle recycling.
The EMBO journal 2003;22(20):5347-57.
2003: György Lonart; Susanne Schoch; Pascal S Kaeser; C Jenny Larkin; Thomas C Südhof; David J Linden
Phosphorylation of RIM1alpha by PKA triggers presynaptic long-term potentiation at cerebellar parallel fiber synapses.
Cell 2003;115(1):49-60.
2003: Jakob B Sørensen; Rafael Fernández-Chacón; Thomas C Südhof; Erwin Neher
Examining synaptotagmin 1 function in dense core vesicle exocytosis under direct control of Ca2+.
The Journal of general physiology 2003;122(3):265-76.
2003: Markus Missler; Weiqi Zhang; Astrid Rohlmann; Gunnar Kattenstroth; Robert E Hammer; Kurt Gottmann; Thomas C Südhof
Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis.
Nature 2003;423(6943):939-48.
2003: Sreeganga Chandra; Xiaocheng Chen; Josep Rizo; Reinhard Jahn; Thomas C Südhof
A broken alpha -helix in folded alpha -Synuclein.
The Journal of biological chemistry 2003;278(17):15313-8.
2003: Reinhard Jahn; Thorsten Lang; Thomas C Südhof
Membrane fusion.
Cell 2003;112(4):519-33.
2003: Yun Wang; Thomas C Südhof
Genomic definition of RIM proteins: evolutionary amplification of a family of synaptic regulatory proteins( small star, filled ).
Genomics 2003;81(2):126-37.
2003: Ok-Ho Shin; Jeong-Seop Rhee; Jiong Tang; Shuzo Sugita; christian rosenmund; Thomas C Südhof
Sr2+ binding to the Ca2+ binding site of the synaptotagmin 1 C2B domain triggers fast exocytosis without stimulating SNARE interactions.
Neuron 2003;37(1):99-108.
2003: Oliver M Schlüter; Francesco Fornai; M G Alessandrí; S Takamori; Martin Geppert; Reinhard Jahn; Thomas C Südhof
Role of alpha-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice.
Neuroscience 2003;118(4):985-1002.
2002: Yun Wang; Xinran Liu; Thomas Biederer; Thomas C Südhof
A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zones.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):14464-9.
2002: Oliver M Schlüter; Mikhail Khvotchev; Reinhard Jahn; Thomas C Südhof
Localization versus function of Rab3 proteins. Evidence for a common regulatory role in controlling fusion.
The Journal of biological chemistry 2002;277(43):40919-29.
2002: Rafael Fernández-Chacón; Ok-Ho Shin; Andreas Königstorfer; Maria F Matos; Alexander C Meyer; Jesus Garcia; Stefan H Gerber; Josep Rizo; Thomas C Südhof; christian rosenmund
Structure/function analysis of Ca2+ binding to the C2A domain of synaptotagmin 1.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(19):8438-46.
2002: Thomas Biederer; Xinwei Cao; Thomas C Südhof; Xinran Liu
Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(17):7340-51.
2002: Dietmar Riedel; Wolfram Antonin; Rafael Fernandez-Chacon; Guillermo Alvarez de Toledo; Tobias Jo; Martin Geppert; Jack A Valentijn; Karin Valentijn; James D Jamieson; Thomas C Südhof; Reinhard Jahn
Rab3D is not required for exocrine exocytosis but for maintenance of normally sized secretory granules.
Molecular and cellular biology 2002;22(18):6487-97.
2002: Thomas Biederer; Yildirim Sara; Marina G Mozhayeva; Deniz Atasoy; Xinran Liu; Ege T Kavalali; Thomas C Südhof
SynCAM, a synaptic adhesion molecule that drives synapse assembly.
Science (New York, N.Y.) 2002;297(5586):1525-31.
2002: Josep Rizo; Thomas C Südhof
Snares and Munc18 in synaptic vesicle fusion.
Nature reviews. Neuroscience 2002;3(8):641-53.
2002: Irina Dulubova; Tomohiro Yamaguchi; Yan Gao; sang-won min; Iryna Huryeva; Thomas C Südhof; Josep Rizo
How Tlg2p/syntaxin 16 'snares' Vps45.
The EMBO journal 2002;21(14):3620-31.
2002: Ok-Ho Shin; Josep Rizo; Thomas C Südhof
Synaptotagmin function in dense core vesicle exocytosis studied in cracked PC12 cells.
Nature neuroscience 2002;5(7):649-56.
2002: Katsuhiko Tabuchi; Thomas C Südhof
Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing.
Genomics 2002;79(6):849-59.
2002: Jun Lu; Jesus Garcia; Irina Dulubova; Thomas C Südhof; Josep Rizo
Solution structure of the Vam7p PX domain.
Biochemistry 2002;41(19):5956-62.
2002: Thomas C Südhof
Synaptotagmins: why so many?
The Journal of biological chemistry 2002;277(10):7629-32.
2002: Tomohiro Yamaguchi; Irina Dulubova; sang-won min; Xiaocheng Chen; Josep Rizo; Thomas C Südhof
Sly1 binds to Golgi and ER syntaxins via a conserved N-terminal peptide motif.
Developmental cell 2002;2(3):295-305.
2002: Sönke Tobaben; Thomas C Südhof; Bernd Stahl
Genetic analysis of alpha-latrotoxin receptors reveals functional interdependence of CIRL/latrophilin 1 and neurexin 1 alpha.
The Journal of biological chemistry 2002;277(8):6359-65.
2002: Shuzo Sugita; Ok-Ho Shin; Weiping Han; Ye Lao; Thomas C Südhof
Synaptotagmins form a hierarchy of exocytotic Ca(2+) sensors with distinct Ca(2+) affinities.
The EMBO journal 2002;21(3):270-80.
2002: Stefan H Gerber; Josep Rizo; Thomas C Südhof
Role of electrostatic and hydrophobic interactions in Ca(2+)-dependent phospholipid binding by the C(2)A-domain from synaptotagmin I.
Diabetes 2002;51 Suppl 1():S12-8.
2002: Stefan H Gerber; Thomas C Südhof
Molecular determinants of regulated exocytosis.
Diabetes 2002;51 Suppl 1():S3-11.
2002: Xiaocheng Chen; Diana R Tomchick; Evguenii Kovrigin; Demet Araç; Mischa Machius; Thomas C Südhof; Josep Rizo
Three-dimensional structure of the complexin/SNARE complex.
Neuron 2002;33(3):397-409.
2002: Pablo E Castillo; Susanne Schoch; Frank Schmitz; Thomas C Südhof; Robert C Malenka
RIM1alpha is required for presynaptic long-term potentiation.
Nature 2002;415(6869):327-30.
2002: Susanne Schoch; Pablo E Castillo; Tobias Jo; Konark Mukherjee; Martin Geppert; Yun Wang; Frank Schmitz; Robert C Malenka; Thomas C Südhof
RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone.
Nature 2002;415(6869):321-6.
2002: Jeong-Seop Rhee; Andrea Betz; Sonja Pyott; Kerstin Reim; Frederique Varoqueaux; Iris Augustin; Dörte Hesse; Thomas C Südhof; Masami Takahashi; christian rosenmund; Nils Brose
Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCs.
Cell 2002;108(1):121-33.
2002: S Sugita; A Ho; Thomas C Südhof
NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern.
Neuroscience 2002;112(1):51-63.
2001: I Fernandez; Demet Araç; Josep Ubach; Stefan H Gerber; Ok-Ho Shin; Y Gao; Richard G W Anderson; Thomas C Südhof; Josep Rizo
Three-dimensional structure of the synaptotagmin 1 C2B-domain: synaptotagmin 1 as a phospholipid binding machine.
Neuron 2001;32(6):1057-69.
2001: Susanne Schoch; Ferenc Deák; Andreas Königstorfer; Marina G Mozhayeva; Yildirim Sara; Thomas C Südhof; Ege T Kavalali
SNARE function analyzed in synaptobrevin/VAMP knockout mice.
Science (New York, N.Y.) 2001;294(5544):1117-22.
2001: György Lonart; Thomas C Südhof
Characterization of rabphilin phosphorylation using phospho-specific antibodies.
Neuropharmacology 2001;41(6):643-9.
2001: Sönke Tobaben; Pratima Thakur; R Fernández-Chacón; Thomas C Südhof; Jens Rettig; Bernd Stahl
A trimeric protein complex functions as a synaptic chaperone machine.
Neuron 2001;31(6):987-99.
2001: Thomas Voets; Tobias Moser; P E Lund; R H Chow; Martin Geppert; Thomas C Südhof; Erwin Neher
Intracellular calcium dependence of large dense-core vesicle exocytosis in the absence of synaptotagmin I.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(20):11680-5.
2001: Thomas Voets; Ruud F G Toonen; Elisabeth C Brian; Heidi de Wit; Tobias Moser; Jens Rettig; Thomas C Südhof; Erwin Neher; Matthijs Verhage
Munc18-1 promotes large dense-core vesicle docking.
Neuron 2001;31(4):581-91.
2001: Stefan H Gerber; Josep Rizo; Thomas C Südhof
The top loops of the C(2) domains from synaptotagmin and phospholipase A(2) control functional specificity.
The Journal of biological chemistry 2001;276(34):32288-92.
2001: Ying Wang; Irina Dulubova; Josep Rizo; Thomas C Südhof
Functional analysis of conserved structural elements in yeast syntaxin Vam3p.
The Journal of biological chemistry 2001;276(30):28598-605.
2001: S Sugita; F Saito; J Tang; J Satz; K Campbell; Thomas C Südhof
A stoichiometric complex of neurexins and dystroglycan in brain.
The Journal of cell biology 2001;154(2):435-45.
2001: Xinwei Cao; Thomas C Südhof
A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60.
Science (New York, N.Y.) 2001;293(5527):115-20.
2001: Josep Ubach; Ye Lao; I Fernandez; Demet Arac; Thomas C Südhof; Josep Rizo
The C2B domain of synaptotagmin I is a Ca2+-binding module.
Biochemistry 2001;40(20):5854-60.
2001: Shuzo Sugita; Weiping Han; Stefan Butz; Xinran Liu; Rafael Fernández-Chacón; Ye Lao; Thomas C Südhof
Synaptotagmin VII as a plasma membrane Ca(2+) sensor in exocytosis.
Neuron 2001;30(2):459-73.
2001: Stefan H Gerber; Jesus Garcia; Josep Rizo; Thomas C Südhof
An unusual C(2)-domain in the active-zone protein piccolo: implications for Ca(2+) regulation of neurotransmitter release.
The EMBO journal 2001;20(7):1605-19.
2001: Barbara Barylko; Stefan H Gerber; Derk D Binns; Nikolai Grichine; Mikhail Khvotchev; Thomas C Südhof; Joseph P Albanesi
A novel family of phosphatidylinositol 4-kinases conserved from yeast to humans.
The Journal of biological chemistry 2001;276(11):7705-8.
2001: Rafael Fernández-Chacón; Andreas Königstorfer; Stefan H Gerber; Jesús García; Maria F Matos; C F Stevens; Nils Brose; Josep Rizo; christian rosenmund; Thomas C Südhof
Synaptotagmin I functions as a calcium regulator of release probability.
Nature 2001;410(6824):41-9.
2001: Irina Dulubova; Tomohiro Yamaguchi; Ying Wang; Thomas C Südhof; Josep Rizo
Vam3p structure reveals conserved and divergent properties of syntaxins.
Nature structural biology 2001;8(3):258-64.
2001: Kerstin Reim; M Mansour; Frederique Varoqueaux; H T McMahon; Thomas C Südhof; Nils Brose; christian rosenmund
Complexins regulate a late step in Ca2+-dependent neurotransmitter release.
Cell 2001;104(1):71-81.
2001: Narimon Honarpour; K Tabuchi; J M Stark; Robert E Hammer; Thomas C Südhof; Luis F Parada; Xinhe Wang; James A Richardson; Joachim Herz
Embryonic neuronal death due to neurotrophin and neurotransmitter deprivation occurs independent of Apaf-1.
Neuroscience 2001;106(2):263-74.
2001: Thomas C Südhof
alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins.
Annual review of neuroscience 2001;24():933-62.
2001: C von Poser; Thomas C Südhof
Synaptotagmin 13: structure and expression of a novel synaptotagmin.
European journal of cell biology 2001;80(1):41-7.
2001: Iris Augustin; S Korte; M Rickmann; Hans A Kretzschmar; Thomas C Südhof; Jochen Herms; Nils Brose
The cerebellum-specific Munc13 isoform Munc13-3 regulates cerebellar synaptic transmission and motor learning in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(1):10-7.
2000: Thomas Biederer; Thomas C Südhof
Mints as adaptors. Direct binding to neurexins and recruitment of munc18.
The Journal of biological chemistry 2000;275(51):39803-6.
2000: Frank Schmitz; Andreas Königstorfer; Thomas C Südhof
RIBEYE, a component of synaptic ribbons: a protein's journey through evolution provides insight into synaptic ribbon function.
Neuron 2000;28(3):857-72.
2000: Sönke Tobaben; Thomas C Südhof; Bernd Stahl
The G protein-coupled receptor CL1 interacts directly with proteins of the Shank family.
The Journal of biological chemistry 2000;275(46):36204-10.
2000: Rafael Fernández-Chacón; Thomas C Südhof
Novel SCAMPs lacking NPF repeats: ubiquitous and synaptic vesicle-specific forms implicate SCAMPs in multiple membrane-trafficking functions.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(21):7941-50.
2000: György Lonart; Thomas C Südhof
Assembly of SNARE core complexes prior to neurotransmitter release sets the readily releasable pool of synaptic vesicles.
The Journal of biological chemistry 2000;275(36):27703-7.
2000: Weiguo Zhang; J L Li; M Hosaka; R Janz; John M Shelton; G M Albright; James A Richardson; Thomas C Südhof; Ronald G Victor
Cyclosporine A-induced hypertension involves synapsin in renal sensory nerve endings.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(17):9765-70.
2000: Mikhail Khvotchev; Thomas C Südhof
alpha-latrotoxin triggers transmitter release via direct insertion into the presynaptic plasma membrane.
The EMBO journal 2000;19(13):3250-62.
2000: Stefan Pabst; J W Hazzard; Wolfram Antonin; Thomas C Südhof; Reinhard Jahn; Josep Rizo; Dirk Fasshauer
Selective interaction of complexin with the neuronal SNARE complex. Determination of the binding regions.
The Journal of biological chemistry 2000;275(26):19808-18.
2000: Maria F Matos; Josep Rizo; Thomas C Südhof
The relation of protein binding to function: what is the significance of munc18 and synaptotagmin binding to syntaxin 1, and where are the corresponding binding sites?
European journal of cell biology 2000;79(6):377-82.
2000: Rafael Fernández-Chacón; M Achiriloaie; R Janz; Joseph P Albanesi; Thomas C Südhof
SCAMP1 function in endocytosis.
The Journal of biological chemistry 2000;275(17):12752-6.
2000: Shuzo Sugita; Thomas C Südhof
Specificity of Ca2+-dependent protein interactions mediated by the C2A domains of synaptotagmins.
Biochemistry 2000;39(11):2940-9.
2000: Matthijs Verhage; Ascanio S Maia; Jaap J Plomp; Arjen B Brussaard; Joost H Heeroma; HJ Vermeer; Ruud F G Toonen; Robert E Hammer; T K van den Berg; Markus Missler; Hans J Geuze; Thomas C Südhof
Synaptic assembly of the brain in the absence of neurotransmitter secretion.
Science (New York, N.Y.) 2000;287(5454):864-9.
2000: Mikhail Khvotchev; György Lonart; Thomas C Südhof
Role of calcium in neurotransmitter release evoked by alpha-latrotoxin or hypertonic sucrose.
Neuroscience 2000;101(3):793-802.
2000: Igor Tsigelny; Ilya N Shindyalov; Philip Bourne; Thomas C Südhof; Palmer Taylor
Common EF-hand motifs in cholinesterases and neuroligins suggest a role for Ca2+ binding in cell surface associations.
Protein science : a publication of the Protein Society 2000;9(1):180-5.
1999: R Janz; Y Goda; Martin Geppert; Markus Missler; Thomas C Südhof
SV2A and SV2B function as redundant Ca2+ regulators in neurotransmitter release.
Neuron 1999;24(4):1003-16.
1999: Rafael Fernández-Chacón; Guillermo Alvarez de Toledo; Robert E Hammer; Thomas C Südhof
Analysis of SCAMP1 function in secretory vesicle exocytosis by means of gene targeting in mice.
The Journal of biological chemistry 1999;274(46):32551-4.
1999: Roger Janz; Thomas C Südhof; R E Hammer; Vivek K Unni; Steven A Siegelbaum; Vadim Y Bolshakov
Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I.
Neuron 1999;24(3):687-700.
1999: M Hosaka; Robert E Hammer; Thomas C Südhof
A phospho-switch controls the dynamic association of synapsins with synaptic vesicles.
Neuron 1999;24(2):377-87.
1999: Gabby Rudenko; THAI NGUYEN; Yogarany Chelliah; Thomas C Südhof; Johann Deisenhofer
The structure of the ligand-binding domain of neurexin Ibeta: regulation of LNS domain function by alternative splicing.
Cell 1999;99(1):93-101.
1999: Anton Maximov; Thomas C Südhof; Ilya Bezprozvanny
Association of neuronal calcium channels with modular adaptor proteins.
The Journal of biological chemistry 1999;274(35):24453-6.
1999: Irina Dulubova; Shuzo Sugita; S Hill; M Hosaka; I Fernandez; Thomas C Südhof; Josep Rizo
A conformational switch in syntaxin during exocytosis: role of munc18.
The EMBO journal 1999;18(16):4372-82.
1999: Iris Augustin; christian rosenmund; Thomas C Südhof; Nils Brose
Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles.
Nature 1999;400(6743):457-61.
1999: Oliver M Schlüter; E Schnell; M Verhage; T Tzonopoulos; R A Nicoll; R Janz; Robert C Malenka; Martin Geppert; Thomas C Südhof
Rabphilin knock-out mice reveal that rabphilin is not required for rab3 function in regulating neurotransmitter release.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(14):5834-46.
1999: Shuzo Sugita; R Janz; Thomas C Südhof
Synaptogyrins regulate Ca2+-dependent exocytosis in PC12 cells.
The Journal of biological chemistry 1999;274(27):18893-901.
1999: J Hazzard; Thomas C Südhof; Josep Rizo
NMR analysis of the structure of synaptobrevin and of its interaction with syntaxin.
Journal of biomolecular NMR 1999;14(3):203-7.
1999: M Okamoto; Susanne Schoch; Thomas C Südhof
EHSH1/intersectin, a protein that contains EH and SH3 domains and binds to dynamin and SNAP-25. A protein connection between exocytosis and endocytosis?
The Journal of biological chemistry 1999;274(26):18446-54.
1999: Stefan Butz; Rafael Fernandez-Chacon; Frank Schmitz; Reinhard Jahn; Thomas C Südhof
The subcellular localizations of atypical synaptotagmins III and VI. Synaptotagmin III is enriched in synapses and synaptic plasma membranes but not in synaptic vesicles.
The Journal of biological chemistry 1999;274(26):18290-6.
1999: M Hosaka; Thomas C Südhof
Homo- and heterodimerization of synapsins.
The Journal of biological chemistry 1999;274(24):16747-53.
1999: Josep Ubach; Jesús García; M P Nittler; Thomas C Südhof; Josep Rizo
Structure of the Janus-faced C2B domain of rabphilin.
Nature cell biology 1999;1(2):106-12.
1999: Bernd Stahl; Sönke Tobaben; Thomas C Südhof
Two distinct domains in hsc70 are essential for the interaction with the synaptic vesicle cysteine string protein.
European journal of cell biology 1999;78(6):375-81.
1999: Bernd Stahl; A Diehlmann; Thomas C Südhof
Direct interaction of Alzheimer's disease-related presenilin 1 with armadillo protein p0071.
The Journal of biological chemistry 1999;274(14):9141-8.
1999: Shuzo Sugita; M Khvochtev; Thomas C Südhof
Neurexins are functional alpha-latrotoxin receptors.
Neuron 1999;22(3):489-96.
1999: J Y Song; Konstantin Ichtchenko; Thomas C Südhof; Nils Brose
Neuroligin 1 is a postsynaptic cell-adhesion molecule of excitatory synapses.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(3):1100-5.
1999: R Janz; Thomas C Südhof
SV2C is a synaptic vesicle protein with an unusually restricted localization: anatomy of a synaptic vesicle protein family.
Neuroscience 1999;94(4):1279-90.
1999: R Fernández-Chacón; Thomas C Südhof
Genetics of synaptic vesicle function: toward the complete functional anatomy of an organelle.
Annual review of physiology 1999;61():753-76.
1998: M Missler; Robert E Hammer; Thomas C Südhof
Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit.
The Journal of biological chemistry 1998;273(52):34716-23.
1998: Shuzo Sugita; Konstantin Ichtchenko; Mikhail Khvotchev; Thomas C Südhof
alpha-Latrotoxin receptor CIRL/latrophilin 1 (CL1) defines an unusual family of ubiquitous G-protein-linked receptors. G-protein coupling not required for triggering exocytosis.
The Journal of biological chemistry 1998;273(49):32715-24.
1998: Xinli Shao; I Fernandez; Thomas C Südhof; Josep Rizo
Solution structures of the Ca2+-free and Ca2+-bound C2A domain of synaptotagmin I: does Ca2+ induce a conformational change?
Biochemistry 1998;37(46):16106-15.
1998: R Janz; Kay Hofmann; Thomas C Südhof
SVOP, an evolutionarily conserved synaptic vesicle protein, suggests novel transport functions of synaptic vesicles.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(22):9269-81.
1998: Konstantin Ichtchenko; Mikhail Khvotchev; N Kiyatkin; L Simpson; Shuzo Sugita; Thomas C Südhof
alpha-latrotoxin action probed with recombinant toxin: receptors recruit alpha-latrotoxin but do not transduce an exocytotic signal.
The EMBO journal 1998;17(21):6188-99.
1998: M Okamoto; Thomas C Südhof
Mint 3: a ubiquitous mint isoform that does not bind to munc18-1 or -2.
European journal of cell biology 1998;77(3):161-5.
1998: György Lonart; R Janz; K M Johnson; Thomas C Südhof
Mechanism of action of rab3A in mossy fiber LTP.
Neuron 1998;21(5):1141-50.
1998: Markus Missler; Rafael Fernandez-Chacon; Thomas C Südhof
The making of neurexins.
Journal of neurochemistry 1998;71(4):1339-47.
1998: I Fernandez; Josep Ubach; Irina Dulubova; X Zhang; Thomas C Südhof; Josep Rizo
Three-dimensional structure of an evolutionarily conserved N-terminal domain of syntaxin 1A.
Cell 1998;94(6):841-9.
1998: Stefan Butz; M Okamoto; Thomas C Südhof
A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain.
Cell 1998;94(6):773-82.
1998: X Zhang; Josep Rizo; Thomas C Südhof
Mechanism of phospholipid binding by the C2A-domain of synaptotagmin I.
Biochemistry 1998;37(36):12395-403.
1998: Mikhail Khvotchev; Thomas C Südhof
Newly synthesized phosphatidylinositol phosphates are required for synaptic norepinephrine but not glutamate or gamma-aminobutyric acid (GABA) release.
The Journal of biological chemistry 1998;273(34):21451-4.
1998: Josep Ubach; X Zhang; Xinli Shao; Thomas C Südhof; Josep Rizo
Ca2+ binding to synaptotagmin: how many Ca2+ ions bind to the tip of a C2-domain?
The EMBO journal 1998;17(14):3921-30.
1998: Andrea Betz; Uri Ashery; M Rickmann; Iris Augustin; Erwin Neher; Thomas C Südhof; Jens Rettig; Nils Brose
Munc13-1 is a presynaptic phorbol ester receptor that enhances neurotransmitter release.
Neuron 1998;21(1):123-36.
1998: Josep Rizo; Thomas C Südhof
C2-domains, structure and function of a universal Ca2+-binding domain.
The Journal of biological chemistry 1998;273(26):15879-82.
1998: M Hosaka; Thomas C Südhof
Synapsin III, a novel synapsin with an unusual regulation by Ca2+.
The Journal of biological chemistry 1998;273(22):13371-4.
1998: Lothar Esser; C R Wang; M Hosaka; Cynthia S Smagula; Thomas C Südhof; Johann Deisenhofer
Synapsin I is structurally similar to ATP-utilizing enzymes.
The EMBO journal 1998;17(4):977-84.
1998: R Janz; Thomas C Südhof
Cellugyrin, a novel ubiquitous form of synaptogyrin that is phosphorylated by pp60c-src.
The Journal of biological chemistry 1998;273(5):2851-7.
1998: Mikhail Khvotchev; Thomas C Südhof
Developmentally regulated alternative splicing in a novel synaptojanin.
The Journal of biological chemistry 1998;273(4):2306-11.
1998: Martin Geppert; Mikhail Khvotchev; Valery Krasnoperov; Y Goda; Markus Missler; Robert E Hammer; Konstantin Ichtchenko; Alexander G Petrenko; Thomas C Südhof
Neurexin I alpha is a major alpha-latrotoxin receptor that cooperates in alpha-latrotoxin action.
The Journal of biological chemistry 1998;273(3):1705-10.
1998: M Hosaka; Thomas C Südhof
Synapsins I and II are ATP-binding proteins with differential Ca2+ regulation.
The Journal of biological chemistry 1998;273(3):1425-9.
1998: György Lonart; Thomas C Südhof
Region-specific phosphorylation of rabphilin in mossy fiber nerve terminals of the hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(2):634-40.
1998: Martin Geppert; Thomas C Südhof
RAB3 and synaptotagmin: the yin and yang of synaptic membrane fusion.
Annual review of neuroscience 1998;21():75-95.
1998: Markus Missler; Thomas C Südhof
Neurexins: three genes and 1001 products.
Trends in genetics : TIG 1998;14(1):20-6.
1997: THAI NGUYEN; Thomas C Südhof
Binding properties of neuroligin 1 and neurexin 1beta reveal function as heterophilic cell adhesion molecules.
The Journal of biological chemistry 1997;272(41):26032-9.
1997: Xinli Shao; Thomas C Südhof; Josep Rizo
Assignment of the 1H, 15N and 13C resonances of the calcium-free and calcium-bound forms of the first C2-domain of synaptotagmin I.
Journal of biomolecular NMR 1997;10(3):307-8.
1997: I Telemenakis; F Benseler; K Stenius; Thomas C Südhof; Nils Brose
Rat homologues of yeast sec7p.
European journal of cell biology 1997;74(2):143-9.
1997: C R Wang; Lothar Esser; Cynthia S Smagula; Thomas C Südhof; Johann Deisenhofer
Identification, expression, and crystallization of the protease-resistant conserved domain of synapsin I.
Protein science : a publication of the Protein Society 1997;6(10):2264-7.
1997: Ying Wang; M Okamoto; Frank Schmitz; Kay Hofmann; Thomas C Südhof
Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion.
Nature 1997;388(6642):593-8.
1997: Yukiko Goda; Thomas C Südhof
Calcium regulation of neurotransmitter release: reliably unreliable?
Current opinion in cell biology 1997;9(4):513-8.
1997: Martin Geppert; Y Goda; C F Stevens; Thomas C Südhof
The small GTP-binding protein Rab3A regulates a late step in synaptic vesicle fusion.
Nature 1997;387(6635):810-4.
1997: C von Poser; Konstantin Ichtchenko; Xinli Shao; Josep Rizo; Thomas C Südhof
The evolutionary pressure to inactivate. A subclass of synaptotagmins with an amino acid substitution that abolishes Ca2+ binding.
The Journal of biological chemistry 1997;272(22):14314-9.
1997: Matthijs Verhage; Klaas Jan de Vries; H Røshol; J Peter H Burbach; Willem Hendrik Gispen; Thomas C Südhof
DOC2 proteins in rat brain: complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion.
Neuron 1997;18(3):453-61.
1997: Xinli Shao; C Li; I Fernandez; X Zhang; Thomas C Südhof; Josep Rizo
Synaptotagmin-syntaxin interaction: the C2 domain as a Ca2+-dependent electrostatic switch.
Neuron 1997;18(1):133-42.
1996: Thomas C Südhof; Josep Rizo
Synaptotagmins: C2-domain proteins that regulate membrane traffic.
Neuron 1996;17(3):379-88.
1996: E R Chapman; Juan Blasi; S An; N Brose; P A Johnston; Thomas C Südhof; Reinhard Jahn
Fatty acylation of synaptotagmin in PC12 cells and synaptosomes.
Biochemical and biophysical research communications 1996;225(1):326-32.
1996: Alexander G Petrenko; B Ullrich; Markus Missler; Valery Krasnoperov; T W Rosahl; Thomas C Südhof
Structure and evolution of neurexophilin.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(14):4360-9.
1996: Xinli Shao; Bazbek Davletov; R B Sutton; Thomas C Südhof; Josep Rizo
Bipartite Ca2+-binding motif in C2 domains of synaptotagmin and protein kinase C.
Science (New York, N.Y.) 1996;273(5272):248-51.
1996: H T McMahon; Vadim Y Bolshakov; R Janz; Robert E Hammer; Steven A Siegelbaum; Thomas C Südhof
Synaptophysin, a major synaptic vesicle protein, is not essential for neurotransmitter release.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(10):4760-4.
1996: Y Hata; S Butz; Thomas C Südhof
CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(8):2488-94.
1996: B Stahl; J H Chou; C Li; Thomas C Südhof; Reinhard Jahn
Rab3 reversibly recruits rabphilin to synaptic vesicles by a mechanism analogous to raf recruitment by ras.
The EMBO journal 1996;15(8):1799-809.
1996: Konstantin Ichtchenko; THAI NGUYEN; Thomas C Südhof
Structures, alternative splicing, and neurexin binding of multiple neuroligins.
The Journal of biological chemistry 1996;271(5):2676-82.
1996: Shuzo Sugita; Y Hata; Thomas C Südhof
Distinct Ca(2+)-dependent properties of the first and second C2-domains of synaptotagmin I.
The Journal of biological chemistry 1996;271(3):1262-5.
1995: K Stenius; R Janz; Thomas C Südhof; Reinhard Jahn
Structure of synaptogyrin (p29) defines novel synaptic vesicle protein.
The Journal of cell biology 1995;131(6 Pt 2):1801-9.
1995: D M Spillane; T W Rosahl; Thomas C Südhof; Robert C Malenka
Long-term potentiation in mice lacking synapsins.
Neuropharmacology 1995;34(11):1573-9.
1995: B Ullrich; Thomas C Südhof
Differential distributions of novel synaptotagmins: comparison to synapsins.
Neuropharmacology 1995;34(11):1371-7.
1995: N Brose; Kay Hofmann; Y Hata; Thomas C Südhof
Mammalian homologues of Caenorhabditis elegans unc-13 gene define novel family of C2-domain proteins.
The Journal of biological chemistry 1995;270(42):25273-80.
1995: C Li; Bazbek Davletov; Thomas C Südhof
Distinct Ca2+ and Sr2+ binding properties of synaptotagmins. Definition of candidate Ca2+ sensors for the fast and slow components of neurotransmitter release.
The Journal of biological chemistry 1995;270(42):24898-902.
1995: Bazbek Davletov; Valery Krasnoperov; Y Hata; Alexander G Petrenko; Thomas C Südhof
High affinity binding of alpha-latrotoxin to recombinant neurexin I alpha.
The Journal of biological chemistry 1995;270(41):23903-5.
1995: H T McMahon; Markus Missler; C Li; Thomas C Südhof
Complexins: cytosolic proteins that regulate SNAP receptor function.
Cell 1995;83(1):111-9.
1995: Thomas C Südhof
The synaptic vesicle cycle: a cascade of protein-protein interactions.
Nature 1995;375(6533):645-53.
1995: C Li; B Ullrich; J Z Zhang; Richard G W Anderson; N Brose; Thomas C Südhof
Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins.
Nature 1995;375(6532):594-9.
1995: T W Rosahl; D Spillane; Markus Missler; Joachim Herz; D K Selig; J R Wolff; Robert E Hammer; Robert C Malenka; Thomas C Südhof
Essential functions of synapsins I and II in synaptic vesicle regulation.
Nature 1995;375(6531):488-93.
1995: Y Hata; Thomas C Südhof
A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic.
The Journal of biological chemistry 1995;270(22):13022-8.
1995: Konstantin Ichtchenko; Y Hata; THAI NGUYEN; B Ullrich; Markus Missler; Carolyn Moomaw; Thomas C Südhof
Neuroligin 1: a splice site-specific ligand for beta-neurexins.
Cell 1995;81(3):435-43.
1995: L H Wang; Thomas C Südhof; Richard G W Anderson
The appendage domain of alpha-adaptin is a high affinity binding site for dynamin.
The Journal of biological chemistry 1995;270(17):10079-83.
1995: R B Sutton; Bazbek Davletov; Albert Berghuis; Thomas C Südhof; Stephen R Sprang
Structure of the first C2 domain of synaptotagmin I: a novel Ca2+/phospholipid-binding fold.
Cell 1995;80(6):929-38.
1995: E M Fykse; C Li; Thomas C Südhof
Phosphorylation of rabphilin-3A by Ca2+/calmodulin- and cAMP-dependent protein kinases in vitro.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(3 Pt 2):2385-95.
1995: B Ullrich; Y A Ushkaryov; Thomas C Südhof
Cartography of neurexins: more than 1000 isoforms generated by alternative splicing and expressed in distinct subsets of neurons.
Neuron 1995;14(3):497-507.
1995: H T McMahon; Thomas C Südhof
Synaptic core complex of synaptobrevin, syntaxin, and SNAP25 forms high affinity alpha-SNAP binding site.
The Journal of biological chemistry 1995;270(5):2213-7.
1995: R Janz; Thomas C Südhof
A systematic approach to studying synaptic function in vertebrates.
Cold Spring Harbor symposia on quantitative biology 1995;60():309-14.
1995: X Li; T W Rosahl; Thomas C Südhof; Uta Francke
Mapping of synapsin II (SYN2) genes to human chromosome 3p and mouse chromosome 6 band F.
Cytogenetics and cell genetics 1995;71(3):301-5.
1994: B Ullrich; C Li; J Z Zhang; H McMahon; Richard G W Anderson; Martin Geppert; Thomas C Südhof
Functional properties of multiple synaptotagmins in brain.
Neuron 1994;13(6):1281-91.
1994: G Fischer von Mollard; B Stahl; Christiane Walch-Solimena; Kohji Takei; L Daniels; A Khoklatchev; Pietro De Camilli; Thomas C Südhof; Reinhard Jahn
Localization of Rab5 to synaptic vesicles identifies endosomal intermediate in synaptic vesicle recycling pathway.
European journal of cell biology 1994;65(2):319-26.
1994: C L Newton; G A Mignery; Thomas C Südhof
Co-expression in vertebrate tissues and cell lines of multiple inositol 1,4,5-trisphosphate (InsP3) receptors with distinct affinities for InsP3.
The Journal of biological chemistry 1994;269(46):28613-9.
1994: Bazbek Davletov; Thomas C Südhof
Ca(2+)-dependent conformational change in synaptotagmin I.
The Journal of biological chemistry 1994;269(46):28547-50.
1994: Martin Geppert; Y Goda; Robert E Hammer; C Li; T W Rosahl; C F Stevens; Thomas C Südhof
Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse.
Cell 1994;79(4):717-27.
1994: T Hayashi; H McMahon; Shinji Yamasaki; T Binz; Y Hata; Thomas C Südhof; H Niemann
Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly.
The EMBO journal 1994;13(21):5051-61.
1994: C Li; K Takei; Martin Geppert; L Daniell; K Stenius; E R Chapman; Reinhard Jahn; Pietro De Camilli; Thomas C Südhof
Synaptic targeting of rabphilin-3A, a synaptic vesicle Ca2+/phospholipid-binding protein, depends on rab3A/3C.
Neuron 1994;13(4):885-98.
1994: J Z Zhang; Bazbek Davletov; Thomas C Südhof; Richard G W Anderson
Synaptotagmin I is a high affinity receptor for clathrin AP-2: implications for membrane recycling.
Cell 1994;78(5):751-60.
1994: J P Liu; K A Powell; Thomas C Südhof; P J Robinson
Dynamin I is a Ca(2+)-sensitive phospholipid-binding protein with very high affinity for protein kinase C.
The Journal of biological chemistry 1994;269(33):21043-50.
1994: Martin Geppert; B Ullrich; Daniel G Green; K Takei; L Daniels; Pietro De Camilli; Thomas C Südhof; Robert E Hammer
Synaptic targeting domains of synapsin I revealed by transgenic expression in photoreceptor cells.
The EMBO journal 1994;13(16):3720-7.
1994: P J Robinson; J P Liu; K A Powell; E M Fykse; Thomas C Südhof
Phosphorylation of dynamin I and synaptic-vesicle recycling.
Trends in neurosciences 1994;17(8):348-53.
1994: O Reizes; Barbara Barylko; C Li; Thomas C Südhof; Joseph P Albanesi
Domain structure of a mammalian myosin I beta.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(14):6349-53.
1994: Martin Geppert; Vadim Y Bolshakov; Steven A Siegelbaum; K Takei; Pietro De Camilli; Robert E Hammer; Thomas C Südhof
The role of Rab3A in neurotransmitter release.
Nature 1994;369(6480):493-7.
1994: Shinji Yamasaki; A Baumeister; T Binz; Juan Blasi; E Link; F Cornille; B Roques; E M Fykse; Thomas C Südhof; Reinhard Jahn
Cleavage of members of the synaptobrevin/VAMP family by types D and F botulinal neurotoxins and tetanus toxin.
The Journal of biological chemistry 1994;269(17):12764-72.
1994: Yuri A Ushkaryov; Y Hata; Konstantin Ichtchenko; Carolyn Moomaw; S Afendis; C A Slaughter; Thomas C Südhof
Conserved domain structure of beta-neurexins. Unusual cleaved signal sequences in receptor-like neuronal cell-surface proteins.
The Journal of biological chemistry 1994;269(16):11987-92.
1994: G Fischer von Mollard; B Stahl; A Khokhlatchev; Thomas C Südhof; Reinhard Jahn
Rab3C is a synaptic vesicle protein that dissociates from synaptic vesicles after stimulation of exocytosis.
The Journal of biological chemistry 1994;269(15):10971-4.
1994: G Fischer von Mollard; B Stahl; C Li; Thomas C Südhof; Reinhard Jahn
Rab proteins in regulated exocytosis.
Trends in biochemical sciences 1994;19(4):164-8.
1994: J M Sontag; E M Fykse; Yuri A Ushkaryov; J P Liu; P J Robinson; Thomas C Südhof
Differential expression and regulation of multiple dynamins.
The Journal of biological chemistry 1994;269(6):4547-54.
1994: Kohji Takei; G A Mignery; E Mugnaini; Thomas C Südhof; Pietro De Camilli
Inositol 1,4,5-trisphosphate receptor causes formation of ER cisternal stacks in transfected fibroblasts and in cerebellar Purkinje cells.
Neuron 1994;12(2):327-42.
1994: T Binz; Juan Blasi; Shinji Yamasaki; A Baumeister; E Link; Thomas C Südhof; Reinhard Jahn; H Niemann
Proteolysis of SNAP-25 by types E and A botulinal neurotoxins.
The Journal of biological chemistry 1994;269(3):1617-20.
1994: Reinhard Jahn; Thomas C Südhof
Synaptic vesicles and exocytosis.
Annual review of neuroscience 1994;17():219-46.
1994: B Ullrich; Thomas C Südhof
Distribution of synaptic markers in the retina: implications for synaptic vesicle traffic in ribbon synapses.
Journal of physiology, Paris 1994;88(4):249-57.
1993: Bazbek Davletov; Thomas C Südhof
A single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid binding.
The Journal of biological chemistry 1993;268(35):26386-90.
1993: Y Hata; C A Slaughter; Thomas C Südhof
Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin.
Nature 1993;366(6453):347-51.
1993: T W Rosahl; Martin Geppert; D Spillane; Joachim Herz; Robert E Hammer; Robert C Malenka; Thomas C Südhof
Short-term synaptic plasticity is altered in mice lacking synapsin I.
Cell 1993;75(4):661-70.
1993: E M Fykse; K Takei; C Walch-Solimena; Martin Geppert; Reinhard Jahn; Pietro De Camilli; Thomas C Südhof
Relative properties and localizations of synaptic vesicle protein isoforms: the case of the synaptophysins.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1993;13(11):4997-5007.
1993: Thomas C Südhof; Pietro De Camilli; H Niemann; Reinhard Jahn
Membrane fusion machinery: insights from synaptic proteins.
Cell 1993;75(1):1-4.
1993: P J Robinson; J M Sontag; J P Liu; E M Fykse; C Slaughter; H McMahon; Thomas C Südhof
Dynamin GTPase regulated by protein kinase C phosphorylation in nerve terminals.
Nature 1993;365(6442):163-6.
1993: Juan Blasi; E R Chapman; E Link; T Binz; Shinji Yamasaki; Pietro De Camilli; Thomas C Südhof; H Niemann; Reinhard Jahn
Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25.
Nature 1993;365(6442):160-3.
1993: E Link; H McMahon; G Fischer von Mollard; Shinji Yamasaki; H Niemann; Thomas C Südhof; Reinhard Jahn
Cleavage of cellubrevin by tetanus toxin does not affect fusion of early endosomes.
The Journal of biological chemistry 1993;268(25):18423-6.
1993: Christiane Walch-Solimena; Kohji Takei; Kenneth Marek; K Midyett; Thomas C Südhof; Pietro De Camilli; Reinhard Jahn
Synaptotagmin: a membrane constituent of neuropeptide-containing large dense-core vesicles.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1993;13(9):3895-903.
1993: H T McMahon; Yuri A Ushkaryov; L Edelmann; E Link; T Binz; H Niemann; Reinhard Jahn; Thomas C Südhof
Cellubrevin is a ubiquitous tetanus-toxin substrate homologous to a putative synaptic vesicle fusion protein.
Nature 1993;364(6435):346-9.
1993: Yuri A Ushkaryov; Thomas C Südhof
Neurexin III alpha: extensive alternative splicing generates membrane-bound and soluble forms.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(14):6410-4.
1993: Reinhard Jahn; Thomas C Südhof
Synaptic vesicle traffic: rush hour in the nerve terminal.
Journal of neurochemistry 1993;61(1):12-21.
1993: M Baumert; G Fischer von Mollard; Reinhard Jahn; Thomas C Südhof
Structure of the murine rab3A gene: correlation of genomic organization with antibody epitopes.
The Biochemical journal 1993;293 ( Pt 1)():157-63.
1993: Scott A Armstrong; Miguel C Seabra; Thomas C Südhof; Joseph L Goldstein; Michael S Brown
cDNA cloning and expression of the alpha and beta subunits of rat Rab geranylgeranyl transferase.
The Journal of biological chemistry 1993;268(16):12221-9.
1993: Christiane Walch-Solimena; Reinhard Jahn; Thomas C Südhof
Synaptic vesicle proteins in exocytosis: what do we know?
Current opinion in neurobiology 1993;3(3):329-36.
1993: Bazbek Davletov; J M Sontag; Y Hata; Alexander G Petrenko; E M Fykse; Reinhard Jahn; Thomas C Südhof
Phosphorylation of synaptotagmin I by casein kinase II.
The Journal of biological chemistry 1993;268(9):6816-22.
1993: Y Hata; Bazbek Davletov; Alexander G Petrenko; Reinhard Jahn; Thomas C Südhof
Interaction of synaptotagmin with the cytoplasmic domains of neurexins.
Neuron 1993;10(2):307-15.
1993: Alexander G Petrenko; V D Lazaryeva; Martin Geppert; T A Tarasyuk; Carolyn Moomaw; A V Khokhlatchev; Yuri A Ushkaryov; C Slaughter; I V Nasimov; Thomas C Südhof
Polypeptide composition of the alpha-latrotoxin receptor. High affinity binding protein consists of a family of related high molecular weight polypeptides complexed to a low molecular weight protein.
The Journal of biological chemistry 1993;268(3):1860-7.
1993: Thomas C Südhof; Alexander G Petrenko; V P Whittaker; Reinhard Jahn
Molecular approaches to synaptic vesicle exocytosis.
Progress in brain research 1993;98():235-40.
1992: E Link; L Edelmann; J H Chou; T Binz; Shinji Yamasaki; Ulrich Eisel; M Baumert; Thomas C Südhof; H Niemann; Reinhard Jahn
Tetanus toxin action: inhibition of neurotransmitter release linked to synaptobrevin proteolysis.
Biochemical and biophysical research communications 1992;189(2):1017-23.
1992: Miguel C Seabra; Michael S Brown; C A Slaughter; Thomas C Südhof; Joseph L Goldstein
Purification of component A of Rab geranylgeranyl transferase: possible identity with the choroideremia gene product.
Cell 1992;70(6):1049-57.
1992: H C Lin; Thomas C Südhof; Richard G W Anderson
Annexin VI is required for budding of clathrin-coated pits.
Cell 1992;70(2):283-91.
1992: Miguel C Seabra; Joseph L Goldstein; Thomas C Südhof; Michael S Brown
Rab geranylgeranyl transferase. A multisubunit enzyme that prenylates GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys.
The Journal of biological chemistry 1992;267(20):14497-503.
1992: Yuri A Ushkaryov; Alexander G Petrenko; Martin Geppert; Thomas C Südhof
Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin receptor and laminin.
Science (New York, N.Y.) 1992;257(5066):50-6.
1992: Michela Matteoli; Kohji Takei; M S Perin; Thomas C Südhof; Pietro De Camilli
Exo-endocytotic recycling of synaptic vesicles in developing processes of cultured hippocampal neurons.
The Journal of cell biology 1992;117(4):849-61.
1992: G A Mignery; P A Johnston; Thomas C Südhof
Mechanism of Ca2+ inhibition of inositol 1,4,5-trisphosphate (InsP3) binding to the cerebellar InsP3 receptor.
The Journal of biological chemistry 1992;267(11):7450-5.
1992: Kohji Takei; H Stukenbrok; A Metcalf; G A Mignery; Thomas C Südhof; P Volpe; Pietro De Camilli
Ca2+ stores in Purkinje neurons: endoplasmic reticulum subcompartments demonstrated by the heterogeneous distribution of the InsP3 receptor, Ca(2+)-ATPase, and calsequestrin.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1992;12(2):489-505.
1992: Martin Geppert; Yuri A Ushkaryov; Y Hata; Bazbek Davletov; Alexander G Petrenko; Thomas C Südhof
Neurexins.
Cold Spring Harbor symposia on quantitative biology 1992;57():483-90.
1991: Michela Matteoli; Kohji Takei; Richard S Cameron; P Hurlbut; P A Johnston; Thomas C Südhof; Reinhard Jahn; Pietro De Camilli
Association of Rab3A with synaptic vesicles at late stages of the secretory pathway.
The Journal of cell biology 1991;115(3):625-33.
1991: Thomas C Südhof; C L Newton; B T Archer; Yuri A Ushkaryov; G A Mignery
Structure of a novel InsP3 receptor.
The EMBO journal 1991;10(11):3199-206.
1991: Patricia L Cameron; Thomas C Südhof; Reinhard Jahn; Pietro De Camilli
Colocalization of synaptophysin with transferrin receptors: implications for synaptic vesicle biogenesis.
The Journal of cell biology 1991;115(1):151-64.
1991: Alexander G Petrenko; M S Perin; Bazbek Davletov; Yuri A Ushkaryov; Martin Geppert; Thomas C Südhof
Binding of synaptotagmin to the alpha-latrotoxin receptor implicates both in synaptic vesicle exocytosis.
Nature 1991;353(6339):65-8.
1991: Martin Geppert; B T Archer; Thomas C Südhof
Synaptotagmin II. A novel differentially distributed form of synaptotagmin.
The Journal of biological chemistry 1991;266(21):13548-52.
1991: P A Johnston; B T Archer; K Robinson; G A Mignery; Reinhard Jahn; Thomas C Südhof
rab3A attachment to the synaptic vesicle membrane mediated by a conserved polyisoprenylated carboxy-terminal sequence.
Neuron 1991;7(1):101-9.
1991: Thomas C Südhof; Reinhard Jahn
Proteins of synaptic vesicles involved in exocytosis and membrane recycling.
Neuron 1991;6(5):665-77.
1991: M S Perin; V A Fried; DK Stone; Xiao-Song Xie; Thomas C Südhof
Structure of the 116-kDa polypeptide of the clathrin-coated vesicle/synaptic vesicle proton pump.
The Journal of biological chemistry 1991;266(6):3877-81.
1991: M S Perin; N Brose; Reinhard Jahn; Thomas C Südhof
Domain structure of synaptotagmin (p65)
The Journal of biological chemistry 1991;266(1):623-9.
1991: M S Perin; P A Johnston; T Ozcelik; Reinhard Jahn; Uta Francke; Thomas C Südhof
Structural and functional conservation of synaptotagmin (p65) in Drosophila and humans.
The Journal of biological chemistry 1991;266(1):615-22.
1990: Fu-Shin X Yu; P A Johnston; Thomas C Südhof; Helen L Yin
gCap39, a calcium ion- and polyphosphoinositide-regulated actin capping protein.
Science (New York, N.Y.) 1990;250(4986):1413-5.
1990: G A Mignery; Thomas C Südhof
The ligand binding site and transduction mechanism in the inositol-1,4,5-triphosphate receptor.
The EMBO journal 1990;9(12):3893-8.
1990: P A Johnston; Thomas C Südhof
Evolutionary conservation and structural determinants of the calelectrins (annexins).
Biochemical Society transactions 1990;18(6):1097-8.
1990: P A Johnston; Fu-Shin X Yu; G A Reynolds; Helen L Yin; Carolyn Moomaw; C A Slaughter; Thomas C Südhof
Purification and expression of gCap39. An intracellular and secreted Ca2(+)-dependent actin-binding protein enriched in mononuclear phagocytes.
The Journal of biological chemistry 1990;265(29):17946-52.
1990: B T Archer; T Ozçelik; Reinhard Jahn; Uta Francke; Thomas C Südhof
Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2.
The Journal of biological chemistry 1990;265(28):17267-73.
1990: T Ozçelik; R G Lafreniere; B T Archer; P A Johnston; H F Willard; Uta Francke; Thomas C Südhof
Synaptophysin: structure of the human gene and assignment to the X chromosome in man and mouse.
American journal of human genetics 1990;47(3):551-61.
1990: G A Mignery; C L Newton; B T Archer; Thomas C Südhof
Structure and expression of the rat inositol 1,4,5-trisphosphate receptor.
The Journal of biological chemistry 1990;265(21):12679-85.
1990: P A Johnston; M S Perin; G A Reynolds; Steven A Wasserman; Thomas C Südhof
Two novel annexins from Drosophila melanogaster. Cloning, characterization, and differential expression in development.
The Journal of biological chemistry 1990;265(19):11382-8.
1990: P A Johnston; Thomas C Südhof
The multisubunit structure of synaptophysin. Relationship between disulfide bonding and homo-oligomerization.
The Journal of biological chemistry 1990;265(15):8869-73.
1990: M S Perin; V A Fried; G A Mignery; Reinhard Jahn; Thomas C Südhof
Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C.
Nature 1990;345(6272):260-3.
1990: Thomas C Südhof
The structure of the human synapsin I gene and protein.
The Journal of biological chemistry 1990;265(14):7849-52.
1990: G Fischer von Mollard; G A Mignery; M Baumert; M S Perin; T J Hanson; P M Burger; Reinhard Jahn; Thomas C Südhof
rab3 is a small GTP-binding protein exclusively localized to synaptic vesicles.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(5):1988-92.
1989: G A Mignery; Thomas C Südhof; K Takei; Pietro De Camilli
Putative receptor for inositol 1,4,5-trisphosphate similar to ryanodine receptor.
Nature 1989;342(6246):192-5.
1989: DK Stone; Bill P Crider; Thomas C Südhof; Xiao-Song Xie
Vacuolar proton pumps.
Journal of bioenergetics and biomembranes 1989;21(5):605-20.
1989: Thomas C Südhof; Andrew J Czernik; Hung-Teh Kao; K Takei; P A Johnston; A Horiuchi; S D Kanazir; M A Wagner; M S Perin; Pietro De Camilli
Synapsins: mosaics of shared and individual domains in a family of synaptic vesicle phosphoproteins.
Science (New York, N.Y.) 1989;245(4925):1474-80.
1989: Thomas C Südhof
Synaptic vesicles.
Current opinion in cell biology 1989;1(4):655-9.
1989: Thomas C Südhof; V A Fried; DK Stone; P A Johnston; Xiao-Song Xie
Human endomembrane H+ pump strongly resembles the ATP-synthetase of Archaebacteria.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(16):6067-71.
1989: Thomas C Südhof; M Baumert; M S Perin; Reinhard Jahn
A synaptic vesicle membrane protein is conserved from mammals to Drosophila.
Neuron 1989;2(5):1475-81.
1989: P A Johnston; Reinhard Jahn; Thomas C Südhof
Transmembrane topography and evolutionary conservation of synaptophysin.
The Journal of biological chemistry 1989;264(2):1268-73.
1988: M S Perin; V A Fried; C A Slaughter; Thomas C Südhof
The structure of cytochrome b561, a secretory vesicle-specific electron transport protein.
The EMBO journal 1988;7(9):2697-703.
1988: P A Dawson; Hofmann Sandra; Deneys R van der Westhuyzen; Thomas C Südhof; Michael S Brown; Joseph L Goldstein
Sterol-dependent repression of low density lipoprotein receptor promoter mediated by 16-base pair sequence adjacent to binding site for transcription factor Sp1.
The Journal of biological chemistry 1988;263(7):3372-9.
1988: Thomas C Südhof; C A Slaughter; I Leznicki; P Barjon; G A Reynolds
Human 67-kDa calelectrin contains a duplication of four repeats found in 35-kDa lipocortins.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(3):664-8.
1987: I R van Driel; Joseph L Goldstein; Thomas C Südhof; Michael S Brown
First cysteine-rich repeat in ligand-binding domain of low density lipoprotein receptor binds Ca2+ and monoclonal antibodies, but not lipoproteins.
The Journal of biological chemistry 1987;262(36):17443-9.
1987: Thomas C Südhof; F Lottspeich; Paul Greengard; E Mehl; Reinhard Jahn
The cDNA and derived amino acid sequences for rat and human synaptophysin.
Nucleic acids research 1987;15(22):9607.
1987: Thomas C Südhof; F Lottspeich; Paul Greengard; E Mehl; Reinhard Jahn
A synaptic vesicle protein with a novel cytoplasmic domain and four transmembrane regions.
Science (New York, N.Y.) 1987;238(4830):1142-4.