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David Sugden

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Simon P Fisher; David Sugden
Endogenous melatonin is not obligatory for the regulation of the rat sleep-wake cycle.
Simon P Fisher; David Sugden
Sleep-promoting action of IIK7, a selective MT2 melatonin receptor agonist in the rat.
Emilios Gemenetzidis; Amrita Bose; Adeel M Riaz; Tracy Chaplin; Bryan D Young; Muhammad Ali; David Sugden; Johanna K Thurlow; Sok Ching Cheong; Soo-Hwang Teo; Hong Wan; Ahmad Waseem; Eric K Parkinson; Farida Fortune; Muy-Teck Teh
FOXM1 upregulation is an early event in human squamous cell carcinoma and it is enhanced by nicotine during malignant transformation.

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All Publications

2010: Simon P Fisher; David Sugden
Endogenous melatonin is not obligatory for the regulation of the rat sleep-wake cycle.
Sleep 2010;33(6):833-40.
2009: Simon P Fisher; David Sugden
Sleep-promoting action of IIK7, a selective MT2 melatonin receptor agonist in the rat.
Neuroscience letters 2009;457(2):93-6.
2009: Emilios Gemenetzidis; Amrita Bose; Adeel M Riaz; Tracy Chaplin; Bryan D Young; Muhammad Ali; David Sugden; Johanna K Thurlow; Sok Ching Cheong; Soo-Hwang Teo; Hong Wan; Ahmad Waseem; Eric K Parkinson; Farida Fortune; Muy-Teck Teh
FOXM1 upregulation is an early event in human squamous cell carcinoma and it is enhanced by nicotine during malignant transformation.
PloS one 2009;4(3):e4849.
2008: Simon P Fisher; Kathryn Davidson; Alexander Kulla; David Sugden
Acute sleep-promoting action of the melatonin agonist, ramelteon, in the rat.
Journal of pineal research 2008;45(2):125-32.
2008: Reshma Ramracheya; Dany S Muller; Paul E Squires; Helen Brereton; David Sugden; Guo Huang; Stephanie A Amiel; Peter M Jones; Shanta J Persaud
Function and expression of melatonin receptors on human pancreatic islets.
Journal of pineal research 2008;44(3):273-9.
2007: Andrew Tsotinis; Pandelis A Afroudakis; Kathryn Davidson; Anjali Prashar; David Sugden
Design, synthesis, and melatoninergic activity of new azido- and isothiocyanato-substituted indoles.
Journal of medicinal chemistry 2007;50(25):6436-40.
2007: Andrew Tsotinis; J Gourgourinis; Andreas Eleutheriades; Kathryn Davidson; David Sugden
Design and synthesis of new N-OMe fluoro-indole melatoninergics.
Medicinal chemistry (Shāriqah (United Arab Emirates)) 2007;3(6):561-71.
2007: Natalie Clark; Julie Keeble; Elizabeth S Fernandes; Anna Starr; Lihuan Liang; David Sugden; Patricia de Winter; Susan D Brain
The transient receptor potential vanilloid 1 (TRPV1) receptor protects against the onset of sepsis after endotoxin.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(13):3747-55.
2007: Andrew Tsotinis; Andreas Eleutheriades; Kathryn Davidson; David Sugden
Design and synthesis of new N1 and C3-substituted 4-fluoroindolic melatoninergics.
Current drug discovery technologies 2007;4(3):198-207.
2007: Rüdiger Faust; Peter J Garratt; Maria Angeles Trujillo Pérez; Vincent J-D Piccio; Christian Madsen; Ane Stenstrøm; Bente Frølund; Kathryn Davidson; Muy-Teck Teh; David Sugden
7-Substituted-melatonin and 7-substituted-1-methylmelatonin analogues: effect of substituents on potency and binding affinity.
Bioorganic & medicinal chemistry 2007;15(13):4543-51.
2007: Andrew Tsotinis; Maria Panoussopoulou; Andreas Eleutheriades; Kathryn Davidson; David Sugden
Design, synthesis and melatoninergic activity of new unsubstituted and beta,beta'-difunctionalised 2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-6-alkanamides.
European journal of medicinal chemistry 2007;42(7):1004-13.
2007: Andrew Tsotinis; Andreas Eleutheriades; Kate A Hough; Kathryn Davidson; David Sugden
Design, synthesis and melatoninergic potency of new N-acyl 8,9-dihydro-4-methoxy-7H-2-benzo[de]quinolinalkanamines.
Bioorganic chemistry 2007;35(2):189-204.
2006: Andrew Tsotinis; Marilena Vlachou; Demetris P Papahatjis; Theodora Calogeropoulou; Spyros P Nikas; Peter J Garratt; Vincent J-D Piccio; Stefan Vonhoff; Kathryn Davidson; Muy-Teck Teh; David Sugden
Mapping the melatonin receptor. 7. Subtype selective ligands based on beta-substituted N-acyl-5-methoxytryptamines and beta-substituted N-acyl-5-methoxy-1-methyltryptamines.
Journal of medicinal chemistry 2006;49(12):3509-19.
2005: Katharina Mahn; Consuelo Borrás; Greg A Knock; Paul Taylor; Imran Y Khan; David Sugden; Lucilla Poston; Jeremy P T Ward; Richard M Sharpe; José Viña; Philip I Aaronson; Giovanni E Mann
Dietary soy isoflavone induced increases in antioxidant and eNOS gene expression lead to improved endothelial function and reduced blood pressure in vivo.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(12):1755-7.
2004: David Sugden; Kathryn Davidson; Kate A Hough; Muy-Teck Teh
Melatonin, melatonin receptors and melanophores: a moving story.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2004;17(5):454-60.
2004: David J Davies; Rüdiger Faust; Peter J Garratt; Cécile Marivingt-Mounir; Muy-Teck Teh; David Sugden
Binding affinity and biological activity of oxygen and sulfur isosteres at melatonin receptors as a function of their hydrogen bonding capability.
Bioorganic chemistry 2004;32(1):1-12.
2004: Hana T Al-Majed; Peter M Jones; Shanta J Persaud; David Sugden; Guo Huang; Stephanie A Amiel; Barbara J Whitehouse
ACTH stimulates insulin secretion from MIN6 cells and primary mouse and human islets of Langerhans.
The Journal of endocrinology 2004;180(1):155-66.
2003: David Sugden
Comparison of circadian expression of tryptophan hydroxylase isoform mRNAs in the rat pineal gland using real-time PCR.
Journal of neurochemistry 2003;86(5):1308-11.
2003: Andrew Tsotinis; Maria Panoussopoulou; Kate A Hough; David Sugden
Synthesis and biological evaluation of new beta,beta'-disubstituted 6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl ethylamido melatoninergic ligands.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2003;18(5):297-304.
2003: Andrew Tsotinis; Andreas Eleutheriades; Kate A Hough; David Sugden
Design and synthesis of potent N1-substituted indole melatonin receptor agonists.
Chemical communications (Cambridge, England) 2003;(3):382-3.
2003: James E Bowe; Xiao Feng Li; David Sugden; J A Katzenellenbogen; Benita S Katzenellenbogen; Kevin T O'Byrne
The effects of the phytoestrogen, coumestrol, on gonadotropin-releasing hormone (GnRH) mRNA expression in GT1-7 GnRH neurones.
Journal of neuroendocrinology 2003;15(2):105-8.
2002: Amanda Wyatt; Joern Steinert; Caroline P D Wheeler-Jones; Anthony J Morgan; David Sugden; Jeremy Pearson; Luis Sobrevia; Giovanni E Mann
Early activation of the p42/p44MAPK pathway mediates adenosine-induced nitric oxide production in human endothelial cells: a novel calcium-insensitive mechanism.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(12):1584-94.
2002: Supaporn Ajpru; Angela J McArthur; Hugh D Piggins; David Sugden
Identification of PAC1 receptor isoform mRNAs by real-time PCR in rat suprachiasmatic nucleus.
Brain research. Molecular brain research 2002;105(1-2):29-37.
2002: Rebecca A Houliston; Rosemary J Keogh; David Sugden; Jayesh Dudhia; Tom D Carter; Caroline P D Wheeler-Jones
Protease-activated receptors upregulate cyclooxygenase-2 expression in human endothelial cells.
Thrombosis and haemostasis 2002;88(2):321-8.
2002: Muy-Teck Teh; David Sugden
Desensitization of pigment granule aggregation in Xenopus leavis melanophores: melatonin degradation rather than receptor down-regulation is responsible.
Journal of neurochemistry 2002;81(4):719-27.
2002: Kritonas Iakovou; Athanasia Varvaresou; Angeliki P Kourounakis; K Stead; David Sugden; Andrew Tsotinis
Design, synthesis and biological evaluation of novel beta-substituted indol-3-yl ethylamido melatoninergic analogues.
The Journal of pharmacy and pharmacology 2002;54(1):147-56.
2002: Andrew Tsotinis; Marilena Vlachou; Andreas Eleutheriades; Effie Prinea; Darren Ebreo; Muy-Teck The; David Sugden
Synthesis of N1-phenethyl substituted indole derivatives as new melatoninergic agonists and antagonists.
Chemical & pharmaceutical bulletin 2002;50(1):31-9.
2002: Shanta J Persaud; Helen M Roderigo-Milne; Paul E Squires; David Sugden; Caroline P D Wheeler-Jones; Phil J Marsh; Véronique D Belin; Melanie J Luther; Peter M Jones
A key role for beta-cell cytosolic phospholipase A(2) in the maintenance of insulin stores but not in the initiation of insulin secretion.
Diabetes 2002;51(1):98-104.
2001: SL Gyles; Chris J Burns; Barbara J Whitehouse; David Sugden; Phil J Marsh; Shanta J Persaud; Peter M Jones
ERKs regulate cyclic AMP-induced steroid synthesis through transcription of the steroidogenic acute regulatory (StAR) gene.
The Journal of biological chemistry 2001;276(37):34888-95.
2001: Andrew Tsotinis; Maria Panoussopoulou; S Sivananthan; David Sugden
Synthesis of new tricyclic melatoninergic ligands.
Farmaco (Società chimica italiana : 1989) 2001;56(9):725-9.
2001: Muy-Teck Teh; David Sugden
An endogenous 5-HT(7) receptor mediates pigment granule dispersion in Xenopus laevis melanophores.
British journal of pharmacology 2001;132(8):1799-808.
2000: Angela J McArthur; Andrew N Coogan; Supaporn Ajpru; David Sugden; S M Biello; Hugh D Piggins
Gastrin-releasing peptide phase-shifts suprachiasmatic nuclei neuronal rhythms in vitro.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(14):5496-502.
2000: Chris J Burns; SL Gyles; Shanta J Persaud; David Sugden; Barbara J Whitehouse; Peter M Jones
Phosphoprotein phosphatases regulate steroidogenesis by influencing StAR gene transcription.
Biochemical and biophysical research communications 2000;273(1):35-9.
2000: Rüdiger Faust; Peter J Garratt; R Jones; L K Yeh; Andrew Tsotinis; Maria Panoussopoulou; Theodora Calogeropoulou; Muy-Teck Teh; David Sugden
Mapping the melatonin receptor. 6. Melatonin agonists and antagonists derived from 6H-isoindolo[2,1-a]indoles, 5,6-dihydroindolo[2,1-a]isoquinolines, and 6,7-dihydro-5H-benzo[c]azepino[2,1-a]indoles.
Journal of medicinal chemistry 2000;43(6):1050-61.
2000: Uwe D Behrens; R H Douglas; David Sugden; David J Davies; Hans-Joachim Wagner
Effect of melatonin agonists and antagonists on horizontal cell spinule formation and dopamine release in a fish retina.
Cell and tissue research 2000;299(3):299-306.
2000: N Ting; A Thambyraja; David Sugden; E Scalbert; P Delagrange; VG Wilson
Pharmacological studies on the inhibitory action of melatonin and putative melatonin analogues on porcine vascular smooth muscle.
Naunyn-Schmiedeberg's archives of pharmacology 2000;361(3):327-33.
1999: David Sugden; Angela J McArthur; Supaporn Ajpru; K Duniec; Hugh D Piggins
Expression of mt(1) melatonin receptor subtype mRNA in the entrained rat suprachiasmatic nucleus: a quantitative RT-PCR study across the diurnal cycle.
Brain research. Molecular brain research 1999;72(2):176-82.
1999: KN Ting; NA Blaylock; David Sugden; P Delagrange; E Scalbert; VG Wilson
Molecular and pharmacological evidence for MT1 melatonin receptor subtype in the tail artery of juvenile Wistar rats.
British journal of pharmacology 1999;127(4):987-95.
1999: David Sugden; L K Yeh; Muy-Teck Teh
Design of subtype selective melatonin receptor agonists and antagonists.
Reproduction, nutrition, development 1999;39(3):335-44.
1999: Muy-Teck Teh; David Sugden
The putative melatonin receptor antagonist GR128107 is a partial agonist on Xenopus laevis melanophores.
British journal of pharmacology 1999;126(5):1237-45.
1998: Muy-Teck Teh; David Sugden
Comparison of the structure-activity relationships of melatonin receptor agonists and antagonists: lengthening the N-acyl side-chain has differing effects on potency on Xenopus melanophores.
Naunyn-Schmiedeberg's archives of pharmacology 1998;358(5):522-8.
1998: David J Davies; Peter J Garratt; D A Tocher; Stefan Vonhoff; J Davies; Muy-Teck Teh; David Sugden
Mapping the melatonin receptor. 5. Melatonin agonists and antagonists derived from tetrahydrocyclopent[b]indoles, tetrahydrocarbazoles and hexahydrocyclohept[b]indoles.
Journal of medicinal chemistry 1998;41(4):451-67.
1997: KN Ting; William R Dunn; David J Davies; David Sugden; P Delagrange; B Guardiola-Lemaître; E Scalbert; VG Wilson
Studies on the vasoconstrictor action of melatonin and putative melatonin receptor ligands in the tail artery of juvenile Wistar rats.
British journal of pharmacology 1997;122(7):1299-306.
1997: David Sugden; H Pickering; Muy-Teck Teh; Peter J Garratt
Melatonin receptor pharmacology: toward subtype specificity.
Biology of the cell / under the auspices of the European Cell Biology Organization 1997;89(8):531-7.
1996: H Pickering; S Sword; S Vonhoff; R Jones; David Sugden
Analogues of diverse structure are unable to differentiate native melatonin receptors in the chicken retina, sheep pars tuberalis and Xenopus melanophores.
British journal of pharmacology 1996;119(2):379-87.
1996: David Sugden; N Anwar; David Klein
Rat pineal alpha 1-adrenoceptor subtypes: studies using radioligand binding and reverse transcription-polymerase chain reaction analysis.
British journal of pharmacology 1996;118(5):1246-52.
1996: Peter J Garratt; S Travard; S Vonhoff; A Tsotinis; David Sugden
Mapping the melatonin receptor. 4. Comparison of the binding affinities of a series of substituted phenylalkyl amides.
Journal of medicinal chemistry 1996;39(9):1797-805.
1995: David Sugden; D J Davies; Peter J Garratt; R Jones; S Vonhoff
Radioligand binding affinity and biological activity of the enantiomers of a chiral melatonin analogue.
European journal of pharmacology 1995;287(3):239-43.
1995: Peter J Garratt; R Jones; D A Tocher; David Sugden
Mapping the melatonin receptor. 3. Design and synthesis of melatonin agonists and antagonists derived from 2-phenyltryptamines.
Journal of medicinal chemistry 1995;38(7):1132-9.
1995: David Sugden
Sedative potency and 2-[125I]iodomelatonin binding affinity of melatonin analogues.
Psychopharmacology 1995;117(3):364-70.
1995: David Sugden; N W Chong; D F Lewis
Structural requirements at the melatonin receptor.
British journal of pharmacology 1995;114(3):618-23.
1994: David Sugden
N-acyl-3-amino-5-methoxychromans: a new series of non-indolic melatonin analogues.
European journal of pharmacology 1994;254(3):271-5.
1994: David Sugden
Melatonin: binding site characteristics and biochemical and cellular responses.
Neurochemistry international 1994;24(2):147-57.
1994: N W Chong; David Sugden
Thermodynamic analysis of agonist and antagonist binding to the chicken brain melatonin receptor.
British journal of pharmacology 1994;111(1):295-301.
1993: N W Chong; David Sugden
Antigonadal effects of two novel melatonin analogues in adult Djungarian hamsters.
Journal of pineal research 1993;15(2):104-7.
1993: N W Chong; J E Evans; David Sugden
N-bromoacetyl 5-methoxytryptamine: an irreversible melatonin ligand?
Biochemical and biophysical research communications 1993;193(3):1355-61.
1992: David Sugden; S J Rowe
Protein kinase C activation antagonizes melatonin-induced pigment aggregation in Xenopus laevis melanophores.
The Journal of cell biology 1992;119(6):1515-21.
1992: David Sugden
Effect of putative melatonin receptor antagonists on melatonin-induced pigment aggregation in isolated Xenopus laevis melanophores.
European journal of pharmacology 1992;213(3):405-8.
1991: David Sugden
Aggregation of pigment granules in single cultured Xenopus laevis melanophores by melatonin analogues.
British journal of pharmacology 1991;104(4):922-7.
1991: N W Chong; David Sugden
Guanine nucleotides regulate 2-[125I]iodomelatonin binding sites in chick retinal pigment epithelium but not in neuronal retina.
Journal of neurochemistry 1991;57(2):685-9.
1991: David Sugden
Down-regulation of pinealocyte protein kinase C: effect on alpha 1-adrenergic potentiation of beta-adrenoceptor stimulation of cyclic AMP accumulation and induction of serotonin N-acetyltransferase activity.
Journal of neurochemistry 1991;57(1):216-21.
1990: David Sugden
5-Hydroxytryptamine amplifies beta-adrenergic stimulation of N-acetyltransferase activity in rat pinealocytes.
Journal of neurochemistry 1990;55(5):1655-8.
1990: David Sugden
Pertussis toxin does not inhibit alpha 1-adrenergic potentiation of beta-adrenergic stimulation of cyclic AMP accumulation in rat pinealocytes.
Biochemical and biophysical research communications 1990;168(2):871-7.
1990: David Sugden
Beta-adrenergic regulation of cyclic GMP in rat pinealocytes.
Biochemical and biophysical research communications 1990;167(2):835-41.
1989: David Sugden
Melatonin biosynthesis in the mammalian pineal gland.
Experientia 1989;45(10):922-32.