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Kenji Sugibayashi

Research Profile

Physiology

Skin Absorption

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TOP 3
Masaki Okawara; Kenji Sugibayashi; Hiroaki Todo; Yoshihiro Tokudome; Fumie Hashimoto
Enhancement of diosgenin distribution in the skin by cyclodextrin complexation following oral administration.
Takeshi Oshizaka; Hiroaki Todo; Kenji Sugibayashi
Effect of direction (epidermis-to-dermis and dermis-to-epidermis) on the permeation of several chemical compounds through full-thickness skin and stripped skin.
Yoshihiro Tokudome; Madoka Kage; Kyosuke Nakamura; Kenji Sugibayashi; Hiroaki Todo; Fumie Hashimoto
Effects of soybean peptide and collagen peptide on collagen synthesis in normal human dermal fibroblasts.

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2013: Masaki Okawara; Kenji Sugibayashi; Hiroaki Todo; Yoshihiro Tokudome; Fumie Hashimoto
Enhancement of diosgenin distribution in the skin by cyclodextrin complexation following oral administration.
Biological & pharmaceutical bulletin 2013;36(1):36-40.
2012: Takeshi Oshizaka; Hiroaki Todo; Kenji Sugibayashi
Effect of direction (epidermis-to-dermis and dermis-to-epidermis) on the permeation of several chemical compounds through full-thickness skin and stripped skin.
Pharmaceutical research 2012;29(9):2477-88.
2012: Yoshihiro Tokudome; Madoka Kage; Kyosuke Nakamura; Kenji Sugibayashi; Hiroaki Todo; Fumie Hashimoto
Effects of soybean peptide and collagen peptide on collagen synthesis in normal human dermal fibroblasts.
International journal of food sciences and nutrition 2012;63(6):689-95.
2012: Kazuhiro Inoue; Kenji Sugibayashi
In vivo enhancement of transdermal absorption of ketotifen by supersaturation generated by amorphous form of the drug.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2012;47(1):228-34.
2012: Takeshi Oshizaka; Hiroaki Todo; Kenji Sugibayashi
[Evaluation of efficacy and safety of drugs penetrated into skin using their physicochemical parameters].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2012;132(11):1237-43.
2012: Eriko Kimura; Yoshiaki Ikarashi; Yuichiro Kawano; Hiroaki Todo; Kenji Sugibayashi
Measurement of skin permeation/penetration of nanoparticles for their safety evaluation.
Biological & pharmaceutical bulletin 2012;35(9):1476-86.
2012: Daisuke Horita; Hiroaki Todo; Kenji Sugibayashi
Effect of ethanol pretreatment on skin permeation of drugs.
Biological & pharmaceutical bulletin 2012;35(8):1343-8.
2012: Hiroshi Ishii; Konomi Fujino; Hiroaki Todo; Kenji Sugibayashi
Evaluation of the skin blanching of topically applied steroids using a chroma meter in animals.
Experimental animals / Japanese Association for Laboratory Animal Science 2012;61(2):147-56.
2012: Eriko Kimura; Hiroaki Todo; Kenji Sugibayashi
[Safety and skin penetration of nanoparticles].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2012;132(3):319-24.
2012: Hiroyuki Takeuchi; Hiroaki Todo; Hidetoshi Urano; Atsushi Furuya; Masahiro Ishida; Kenji Sugibayashi
Influence of skin thickness on the in vitro permeabilities of drugs through Sprague-Dawley rat or Yucatan micropig skin.
Biological & pharmaceutical bulletin 2012;35(2):192-202.
2011: Shin-Ichi Harada; Eijiro Horisawa; Satoshi Kano; Kenji Sugibayashi
Formulation study of topically applied O/W lotion containing vitamin D3 derivative, focusing on skin permeability of the drug.
Drug development and industrial pharmacy 2011;37(8):917-25.
2011: Dianxiu Cao; Yuko Tazawa; Hiroshi Ishii; Hiroaki Todo; Kenji Sugibayashi
Pretreatment effects of moxibustion on the skin permeation and skin and muscle concentrations of salicylate in rats.
International journal of pharmaceutics 2011;407(1-2):105-10.
2011: Hiroshi Ishii; Tsukasa Suzuki; Hiroaki Todo; Mitsuhiro Kamimura; Kenji Sugibayashi
Iontophoresis-facilitated delivery of prednisolone through throat skin to the trachea after topical application of its succinate salt.
Pharmaceutical research 2011;28(4):839-47.
2011: Hiroyuki Takeuchi; Shuichi Terasaka; Hidetoshi Urano; Atsushi Furuya; Yoko Mano; Takanobu Sakurai; Kenji Sugibayashi
Usefulness of rat skin as a substitute for human skin in the in vitro skin permeation study.
Experimental animals / Japanese Association for Laboratory Animal Science 2011;60(4):373-84.
2011: Kaori Matsumoto; Eiichi Nemoto; Tetsuya Hasegawa; Masayuki Akimoto; Kenji Sugibayashi
In vitro characterization of the cytochrome P450 isoforms involved in the metabolism of 6-methoxy-2-napthylacetic acid, an active metabolite of the prodrug nabumetone.
Biological & pharmaceutical bulletin 2011;34(5):734-9.
2011: Hiroyuki Takeuchi; Shuichi Terasaka; Takanobu Sakurai; Atsushi Furuya; Hidetoshi Urano; Kenji Sugibayashi
Variation assessment for in vitro permeabilities through Yucatan micropig skin.
Biological & pharmaceutical bulletin 2011;34(4):555-61.
2011: Y Tokudome; M Jinno; Hiroaki Todo; T Kon; Kenji Sugibayashi; Fumie Hashimoto
Increase in ceramide level after application of various sizes of sphingomyelin liposomes to a cultured human skin model.
Skin pharmacology and physiology 2011;24(4):218-23.
2011: Keisuke Yamada; Jun Yamashita; Hiroaki Todo; Keiko Miyamoto; Satoru Hashimoto; Yoshihiro Tokudome; Fumie Hashimoto; Kenji Sugibayashi
Preparation and evaluation of liquid-crystal formulations with skin-permeation-enhancing abilities for entrapped drugs.
Journal of oleo science 2011;60(1):31-40.
2010: Keshu Yan; Hiroaki Todo; Kenji Sugibayashi
Transdermal drug delivery by in-skin electroporation using a microneedle array.
International journal of pharmaceutics 2010;397(1-2):77-83.
2010: Naoko Inoue; Hiroaki Todo; Dai Iidaka; Yoshihiro Tokudome; Fumie Hashimoto; Tohru Kishino; Kenji Sugibayashi
Possibility and effectiveness of drug delivery to skin by needle-free injector.
International journal of pharmaceutics 2010;391(1-2):65-72.
2010: Yoshihiro Tokudome; Raina Uchida; Takeshi Yokote; Hiroaki Todo; Nobuko Hada; Tatsuhiko Kon; Junko Yasuda; Hidenori Hayashi; Fumie Hashimoto; Kenji Sugibayashi
Effect of topically applied sphingomyelin-based liposomes on the ceramide level in a three-dimensional cultured human skin model.
Journal of liposome research 2010;20(1):49-54.
2010: Nanthida Wonglertnirant; Hiroaki Todo; Praneet Opanasopit; Tanasait Ngawhirunpat; Kenji Sugibayashi
Macromolecular delivery into skin using a hollow microneedle.
Biological & pharmaceutical bulletin 2010;33(12):1988-93.
2010: Hiroaki Todo; Eriko Kimura; Hirotaka Yasuno; Yoshihiro Tokudome; Fumie Hashimoto; Yoshiaki Ikarashi; Kenji Sugibayashi
Permeation pathway of macromolecules and nanospheres through skin.
Biological & pharmaceutical bulletin 2010;33(8):1394-9.
2010: Hiroshi Ishii; Hiroaki Todo; Kenji Sugibayashi
Effect of sebum and ointment rubbing on the skin permeation of triamcinolone acetonide from white petrolatum ointment.
Biological & pharmaceutical bulletin 2010;33(5):876-80.
2010: Kenji Sugibayashi; Hiroaki Todo; Takeshi Oshizaka; Yoko Owada
Mathematical model to predict skin concentration of drugs: toward utilization of silicone membrane to predict skin concentration of drugs as an animal testing alternative.
Pharmaceutical research 2010;27(1):134-42.
2009: Masahiro Sugino; Hiroaki Todo; Kenji Sugibayashi
[Skin permeation and transdermal delivery systems of drugs: history to overcome barrier function in the stratum corneum].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2009;129(12):1453-8.
2009: Hiroshi Ishii; Hiroaki Todo; Akira Terao; Tetuya Hasegawa; Masayuki Akimoto; Kouichi Oshima; Kenji Sugibayashi
Why does a hydrophilic drug permeate skin, although it is not soluble in white petrolatum?
Drug development and industrial pharmacy 2009;35(11):1356-63.
2009: Toshihiko Kitamura; Hiroaki Todo; Kenji Sugibayashi
Effect of several electrolyzed waters on the skin permeation of lidocaine, benzoic Acid, and isosorbide mononitrate.
Drug development and industrial pharmacy 2009;35(2):145-53.
2008: Koji Yamaguchi; Tetsuya Mitsui; Yoshinori Aso; Kenji Sugibayashi
Structure-permeability relationship analysis of the permeation barrier properties of the stratum corneum and viable epidermis/dermis of rat skin.
Journal of pharmaceutical sciences 2008;97(10):4391-403.
2008: Daisuke Yoshida; Hiroaki Todo; Tetsuya Hasegawa; Kenji Sugibayashi
Effect of molecular weight on the dermatopharmacokinetics and systemic disposition of drugs after intracutaneous injection.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2008;35(1-2):5-11.
2008: Kenji Sugibayashi; Hiroaki Todo; Eriko Kimura
Safety evaluation of titanium dioxide nanoparticles by their absorption and elimination profiles.
The Journal of toxicological sciences 2008;33(3):293-8.
2008: Daisuke Yoshida; Hiroaki Todo; Tetsuya Hasegawa; Kenji Sugibayashi
Effect of vasoactive agents on the dermatopharmacokinetics and systemic disposition of model compounds, salicylate and FITC-dextran 4 kDa, following intracutaneous injection of the compounds.
International journal of pharmaceutics 2008;356(1-2):181-6.
2008: Dianxiu Cao; Toshihiko Kitamura; Hiroaki Todo; Sun Dong Yoo; Kenji Sugibayashi
Pretreatment effects of moxibustion on the skin permeation of FITC-dextran.
International journal of pharmaceutics 2008;354(1-2):117-25.
2008: Koji Yamaguchi; Keiichi Morita; Tetsuya Mitsui; Yoshinori Aso; Kenji Sugibayashi
Skin permeation and metabolism of a new antipsoriatic vitamin D(3) analogue of structure 16-en-22-oxa-24-carboalkoxide with low calcemic effect.
International journal of pharmaceutics 2008;353(1-2):105-12.
2008: Tetsuya Hasegawa; Asako Kawazome; Kaori Matsumoto; Go Yanagimoto; Teruaki Hayashi; Masayuki Akimoto; Hiroaki Todo; Kenji Sugibayashi
Analysis of skin disposition and metabolism of ethyl nicotinate after topical application using dual agar gel disc-inserted rats.
Biological & pharmaceutical bulletin 2008;31(1):85-9.
2007: Tetsuya Hasegawa; Asako Kawazome; Go Yanagimoto; Teruaki Hayashi; Toshinobu Seki; Masayuki Akimoto; Hiroaki Todo; Kenji Sugibayashi
Analysis of skin disposition of flurbiprofen after topical application using dual agar gel discs-inserted rats.
Biological & pharmaceutical bulletin 2007;30(11):2135-40.
2007: Nobuko Hada; Hiroaki Todo; Fusao Komada; Kenji Sugibayashi
Preparation and evaluation of gene-transfected cultured skin as a novel drug delivery system for severely burned skin.
Pharmaceutical research 2007;24(8):1473-9.
2007: Daisuke Yoshida; Hiroaki Todo; Tetsuya Hasegawa; Kenji Sugibayashi
Dermatopharmacokinetics of salicylate following topical injection in rats: effect of osmotic pressure and injection volume on salicylate disposition.
International journal of pharmaceutics 2007;337(1-2):142-7.
2007: Koji Yamaguchi; Tetsuya Mitsui; Yoshinori Aso; Kenji Sugibayashi
Analysis of in vitro skin permeation of 22-oxacalcitriol from ointments based on a two- or three-layer diffusion model considering diffusivity in a vehicle.
International journal of pharmaceutics 2007;336(2):310-8.
2007: Xue-Ming Wu; Hiroaki Todo; Kenji Sugibayashi
Enhancement of skin permeation of high molecular compounds by a combination of microneedle pretreatment and iontophoresis.
Journal of controlled release : official journal of the Controlled Release Society 2007;118(2):189-95.
2006: Seiji Tokumoto; Naruhito Higo; Kenji Sugibayashi
Effect of electroporation and pH on the iontophoretic transdermal delivery of human insulin.
International journal of pharmaceutics 2006;326(1-2):13-9.
2006: Masayuki Akimoto; Yuko Sato; Toshimi Okubo; Hiroaki Todo; Tetsuya Hasegawa; Kenji Sugibayashi
Conversion of FAD to FMN and riboflavin in plasma: effects of measuring method.
Biological & pharmaceutical bulletin 2006;29(8):1779-82.
2006: Xue-Ming Wu; Hiroaki Todo; Kenji Sugibayashi
Effects of pretreatment of needle puncture and sandpaper abrasion on the in vitro skin permeation of fluorescein isothiocyanate (FITC)-dextran.
International journal of pharmaceutics 2006;316(1-2):102-8.
2006: Koji Yamaguchi; Tetsuya Mitsui; Toshinori Yamamoto; Rie Shiokawa; Yuko Nomiyama; Norihisa Ohishi; Yoshinori Aso; Kenji Sugibayashi
Analysis of in vitro skin permeation of 22-oxacalcitriol having a complicated metabolic pathway.
Pharmaceutical research 2006;23(4):680-8.
2006: Yuki Fujisaki; Tadashi Tsukune; Motomu Funyû; Mutsuo Okumura; Tadashi Ukigaya; Kenji Sugibayashi
Development of sustained-release tablets containing sodium valproate: in vitro and in vivo correlation.
Drug development and industrial pharmacy 2006;32(2):207-17.
2006: Satoshi Kano; Kenji Sugibayashi
Kinetic analysis on the skin disposition of cytotoxicity as an index of skin irritation produced by cetylpyridinium chloride: comparison of in vitro data using a three-dimensional cultured human skin model with in vivo results in hairless mice.
Pharmaceutical research 2006;23(2):329-35.
2005: Nobuko Hada; Tetsuya Hasegawa; Hidekazu Takahashi; Takuya Ishibashi; Kenji Sugibayashi
Cultured skin loaded with tetracycline HCl and chloramphenicol as dermal delivery system: mathematical evaluation of the cultured skin containing antibiotics.
Journal of controlled release : official journal of the Controlled Release Society 2005;108(2-3):341-50.
2005: Kazuhiro Inoue; Kengo Ogawa; Jun'ichi Okada; Kenji Sugibayashi
Enhancement of skin permeation of ketotifen by supersaturation generated by amorphous form of the drug.
Journal of controlled release : official journal of the Controlled Release Society 2005;108(2-3):306-18.
2005: Rakan Matsui; Masaaki Hasegawa; Masami Ishida; Toshiya Ebata; Noriyuki Namiki; Kenji Sugibayashi
Skin permeation of lidocaine from crystal suspended oily formulations.
Drug development and industrial pharmacy 2005;31(8):729-38.
2005: Seiji Tokumoto; Kenji Mori; Naruhito Higo; Kenji Sugibayashi
Effect of electroporation on the electroosmosis across hairless mouse skin in vitro.
Journal of controlled release : official journal of the Controlled Release Society 2005;105(3):296-304.
2005: Makiko Osawa; Nobuko Hada; Kaori Matsumoto; Tetsuya Hasegawa; Daisuke Kobayashi; Yasunori Morimoto; Masatoshi Yamaguchi; Ikuo Kanamoto; Teruaki Nakagawa; Kenji Sugibayashi
Usefulness of coadministration of bucolome in warfarin therapy: pharmacokinetic and pharmacodynamic analysis using outpatient prescriptions.
International journal of pharmaceutics 2005;293(1-2):43-9.
2005: Tetsuya Hasegawa; Soan Kim; Mamoru Tsuchida; Yasunori Issiki; Seiichi Kondo; Kenji Sugibayashi
Decrease in skin permeation and antibacterial effect of parabens by a polymeric additive, poly(2-methacryloyloxyethyl phosphorylcholine-co-butylmetacrylate).
Chemical & pharmaceutical bulletin 2005;53(3):271-6.
2005: Masato Homma; Keisuke Kuga; Kosuke Doki; Kumi Katori; Iwao Yamaguchi; Kenji Sugibayashi; Yukinao Kohda
Assessment of serum flecainide trough levels in patients with tachyarrhythmia.
The Journal of pharmacy and pharmacology 2005;57(1):47-51.
2004: Kenji Sugibayashi; Teruaki Hayashi; Kaori Matsumoto; Tetsuya Hasegawa
Utility of a three-dimensional cultured human skin model as a tool to evaluate the simultaneous diffusion and metabolism of ethyl nicotinate in skin.
Drug metabolism and pharmacokinetics 2004;19(5):352-62.
2004: Yoshihiro Tokudome; Kenji Sugibayashi
Mechanism of the synergic effects of calcium chloride and electroporation on the in vitro enhanced skin permeation of drugs.
Journal of controlled release : official journal of the Controlled Release Society 2004;95(2):267-74.
2004: Yoichi Kobayashi; Tsunehisa Komatsu; Machiko Sumi; Sachihiko Numajiri; Misao Miyamoto; Daisuke Kobayashi; Kenji Sugibayashi; Yasunori Morimoto
In vitro permeation of several drugs through the human nail plate: relationship between physicochemical properties and nail permeability of drugs.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2004;21(4):471-7.
2003: Yoshihiro Tokudome; Kenji Sugibayashi
The effects of calcium chloride and sodium chloride on the electroporation-mediated skin permeation of fluorescein isothiocyanate (FITC)-dextrans in vitro.
Biological & pharmaceutical bulletin 2003;26(10):1508-10.
2003: Yoshihiro Tokudome; Kenji Sugibayashi
The synergic effects of various electrolytes and electroporation on the in vitro skin permeation of calcein.
Journal of controlled release : official journal of the Controlled Release Society 2003;92(1-2):93-101.
2003: Kenji Mori; Tetsuya Hasegawa; Shuji Sato; Kenji Sugibayashi
Effect of electric field on the enhanced skin permeation of drugs by electroporation.
Journal of controlled release : official journal of the Controlled Release Society 2003;90(2):171-9.
2003: Kenji Mori; Seiji Tokumoto; Hiroyuki Kubo; Naruhito Higo; Iwao Nozawa; Shuji Sato; Kenji Sugibayashi
Design and feasibility assessment of topically applied drug formulations for electroporation.
Chemical & pharmaceutical bulletin 2003;51(6):617-9.
2003: Kumi Katori; Masato Homma; Keisuke Kuga; Iwao Yamaguchi; Kenji Sugibayashi; Yukinao Kohda
Liquid chromatographic determination of unbound flecainide in therapeutic drug monitoring.
Journal of pharmaceutical and biomedical analysis 2003;32(2):375-80.
2002: Kenji Sugibayashi; T Watanabe; Tetsuya Hasegawa; Hidekazu Takahashi; Takuya Ishibashi
Kinetic analysis on the in vitro cytotoxicity using Living Skin Equivalent for ranking the toxic potential of dermal irritants.
Toxicology in vitro : an international journal published in association with BIBRA 2002;16(6):759-63.
2002: Yi Jin; Hideki Ohkuma; Hua Wang; Hideshi Natsume; Kenji Sugibayashi; Yasunori Morimoto
[Fast-disintegration oral tablets having sustained release property].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2002;122(11):989-94.
2002: Liang Fang; Yoichi Kobayashi; Sachihiko Numajiri; Daisuke Kobayashi; Kenji Sugibayashi; Yasunori Morimoto
The enhancing effect of a triethanolamine-ethanol-isopropyl myristate mixed system on the skin permeation of acidic drugs.
Biological & pharmaceutical bulletin 2002;25(10):1339-44.
2002: Masaki Uchida; Yi Jin; Hideshi Natsume; Daisuke Kobayashi; Kenji Sugibayashi; Yasunori Morimoto
Introduction of poly-L-lactic acid microspheres into the skin using supersonic flow: effects of helium gas pressure, particle size and microparticle dose on the amount introduced into hairless rat skin.
The Journal of pharmacy and pharmacology 2002;54(6):781-90.
2002: Tetsuya Watanabe; Tetsuya Hasegawa; Hidekazu Takahashi; Takuya Ishibashi; Hiroshi Itagaki; Kenji Sugibayashi
Utility of MTT assay in three-dimensional cultured human skin model as an alternative for draize skin irritation test: approach using diffusion law of irritant in skin and toxicokinetics-toxicodynamics correlation.
Pharmaceutical research 2002;19(5):669-75.
2002: Masaki Uchida; Hideshi Natsume; Daisuke Kobayashi; Kenji Sugibayashi; Yasunori Morimoto
Effects of particle size, helium gas pressure and microparticle dose on the plasma concentration of indomethacin after bombardment of indomethacin-loaded poly-L-lactic acid microspheres using a Helios gun system.
Biological & pharmaceutical bulletin 2002;25(5):690-3.
2002: Daisuke Yoshida; Tetsuya Hasegawa; Kenji Sugibayashi
Targeting of salicylate to skin and muscle following topical injections in rats.
International journal of pharmaceutics 2002;231(2):177-84.
2002: Yasunori Morimoto; Yoshio Wada; Toshinobu Seki; Kenji Sugibayashi
In vitro skin permeation of morphine hydrochloride during the finite application of penetration-enhancing system containing water, ethanol and l-menthol.
Biological & pharmaceutical bulletin 2002;25(1):134-6.
2001: M Miyamoto; Hideshi Natsume; I Satoh; Kazuo Ohtake; M Yamaguchi; Daisuke Kobayashi; Kenji Sugibayashi; Yasunori Morimoto
Effect of poly-L-arginine on the nasal absorption of FITC-dextran of different molecular weights and recombinant human granulocyte colony-stimulating factor (rhG-CSF) in rats.
International journal of pharmaceutics 2001;226(1-2):127-38.
2001: Yi Jin; H Ohkuma; C F Wang; Hideshi Natsume; Kenji Sugibayashi; Yasunori Morimoto
[Pharmaceutical evaluation of fast-disintegrant tablet containing nicorandil-loaded particles].
Yao xue xue bao = Acta pharmaceutica Sinica 2001;36(7):535-8.
2001: M Miyamoto; Hideshi Natsume; S Iwata; Kazuo Ohtake; M Yamaguchi; Daisuke Kobayashi; Kenji Sugibayashi; M Yamashina; Yasunori Morimoto
Improved nasal absorption of drugs using poly-L-arginine: effects of concentration and molecular weight of poly-L-arginine on the nasal absorption of fluorescein isothiocyanate-dextran in rats.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2001;52(1):21-30.
2001: K Sato; N Mitsui; Tetsuya Hasegawa; Kenji Sugibayashi; Yasunori Morimoto
Potential usefulness of solubility index for prediction of the skin permeation rate of 5-ISMN from pressure-sensitive adhesive tape.
Journal of controlled release : official journal of the Controlled Release Society 2001;73(2-3):269-77.
2001: Kenji Sugibayashi; M Yoshida; Kenji Mori; T Watanabe; Tetsuya Hasegawa
Electric field analysis on the improved skin concentration of benzoate by electroporation.
International journal of pharmaceutics 2001;219(1-2):107-12.
2001: Yi Jin; M Uchida; C F Wang; Hideshi Natsume; Kenji Sugibayashi; Yasunori Morimoto
[Transdermal microparticle delivery by a supersonic-Helios gun system].
Yao xue xue bao = Acta pharmaceutica Sinica 2001;36(2):140-4.
2000: S Ohmori; Teruaki Hayashi; M Kawase; S Saito; Kenji Sugibayashi; Yasunori Morimoto
Transdermal delivery of the potent analgesic dihydroetorphine: kinetic analysis of skin permeation and analgesic effect in the hairless rat.
The Journal of pharmacy and pharmacology 2000;52(12):1437-49.
2000: Kenji Sugibayashi; M Kagino; Sachihiko Numajiri; N Inoue; Daisuke Kobayashi; M Kimura; M Yamaguchi; Yasunori Morimoto
Synergistic effects of iontophoresis and jet injector pretreatment on the in-vitro skin permeation of diclofenac and angiotensin II.
The Journal of pharmacy and pharmacology 2000;52(10):1179-86.
2000: E Manabe; Sachihiko Numajiri; Kenji Sugibayashi; Yasunori Morimoto
Analysis of skin permeation-enhancing mechanism of iontophoresis using hydrodynamic pore theory.
Journal of controlled release : official journal of the Controlled Release Society 2000;66(2-3):149-58.
1999: Kenji Sugibayashi; Teruaki Hayashi; Yasunori Morimoto
Simultaneous transport and metabolism of ethyl nicotinate in hairless rat skin after its topical application: the effect of enzyme distribution in skin.
Journal of controlled release : official journal of the Controlled Release Society 1999;62(1-2):201-8.
1999: Kenji Sugibayashi; Go Yanagimoto; Teruaki Hayashi; Toshinobu Seki; Kazuhiko Juni; Yasunori Morimoto
Analysis of skin disposition of flurbiprofen after topical application in hairless rats.
Journal of controlled release : official journal of the Controlled Release Society 1999;62(1-2):193-200.
1999: Ken-ichi Hosoya; H Kubo; Hideshi Natsume; Kenji Sugibayashi; Y Morimoto
Evaluation of bile acids and fusidate derivative as nasal absorption enhancers using an electrophysiological technique.
Biological & pharmaceutical bulletin 1999;22(10):1089-93.
1999: Hideshi Natsume; S Iwata; Kazuo Ohtake; M Miyamoto; M Yamaguchi; Ken-ichi Hosoya; Daisuke Kobayashi; Kenji Sugibayashi; Yasunori Morimoto
Screening of cationic compounds as an absorption enhancer for nasal drug delivery.
International journal of pharmaceutics 1999;185(1):1-12.
1999: K Sakuma; M Ogawa; Kenji Sugibayashi; K Yamada; K Yamamoto
Relationship between tyrosinase inhibitory action and oxidation-reduction potential of cosmetic whitening ingredients and phenol derivatives.
Archives of pharmacal research 1999;22(4):335-9.
1999: Go Yanagimoto; Teruaki Hayashi; Tetsuya Hasegawa; Toshinobu Seki; Kazuhiko Juni; Kenji Sugibayashi; Yasunori Morimoto
Skin disposition of drugs after topical application in hairless rats.
Chemical & pharmaceutical bulletin 1999;47(6):749-54.
1999: Yoichi Kobayashi; Misao Miyamoto; Kenji Sugibayashi; Yasunori Morimoto
Drug permeation through the three layers of the human nail plate.
The Journal of pharmacy and pharmacology 1999;51(3):271-8.
1998: Yoichi Kobayashi; Misao Miyamoto; Kenji Sugibayashi; Yasunori Morimoto
Enhancing effect of N-acetyl-l-cysteine or 2-mercaptoethanol on the in vitro permeation of 5-fluorouracil or tolnaftate through the human nail plate.
Chemical & pharmaceutical bulletin 1998;46(11):1797-802.
1998: Osamu Hosoya; M Sano; Y Wada; Toshinobu Seki; Kenji Sugibayashi; Kazuhiko Juni; Yasunori Morimoto
Effect of several hydrophilic polymers on the permeation of morphine and salicylic acid through excised hairless rat skin.
Chemical & pharmaceutical bulletin 1998;46(5):882-5.
1998: Kenji Sugibayashi; Yasunori Morimoto
[Transdermal therapeutic systems].
Nihon rinsho. Japanese journal of clinical medicine 1998;56(3):619-27.
1997: Y Yamaguchi; T Usami; Hideshi Natsume; T Aoyagi; Y Nagase; Kenji Sugibayashi; Y Morimoto
Evaluation of skin permeability of drugs by newly prepared polymer membranes.
Chemical & pharmaceutical bulletin 1997;45(3):537-41.
1996: H Ueda; M Ogihara; Kenji Sugibayashi; Yasunori Morimoto
Difference in the enhancing effects of ultrasound on the skin permeation of polar and non-polar drugs.
Chemical & pharmaceutical bulletin 1996;44(10):1973-6.
1996: S Numajiri; Kenji Sugibayashi; Yasunori Morimoto
Analysis of in vitro iontophoretic skin permeation of sodium benzoate by transport numbers of drug and additives.
Chemical & pharmaceutical bulletin 1996;44(7):1351-6.
1996: Kenji Sugibayashi; Teruaki Hayashi; T Hatanaka; M Ogihara; Yasunori Morimoto
Analysis of simultaneous transport and metabolism of ethyl nicotinate in hairless rat skin.
Pharmaceutical research 1996;13(6):855-60.
1994: T Hatanaka; E Manabe; Kenji Sugibayashi; Yasunori Morimoto
An application of the hydrodynamic pore theory to percutaneous absorption of drugs.
Pharmaceutical research 1994;11(5):654-8.
1994: Ken-ichi Hosoya; H Kubo; T Akutsu; Hideshi Natsume; Kenji Sugibayashi; Yasunori Morimoto
Effect of sodium taurodihydrofusidate on nasal drug delivery: differences in its concentration and penetrant molecular weight.
Archives of pharmacal research 1994;17(2):57-9.
1994: Ken-ichi Hosoya; H Kubo; Hideshi Natsume; Kenji Sugibayashi; Yasunori Morimoto
Evaluation of enhancers to increase nasal absorption using Ussing chamber technique.
Biological & pharmaceutical bulletin 1994;17(2):316-22.
1994: D Kobayashi; T Matsuzawa; Kenji Sugibayashi; Yasunori Morimoto; M Kimura
Analysis of the combined effect of 1-menthol and ethanol as skin permeation enhancers based on a two-layer skin model.
Pharmaceutical research 1994;11(1):96-103.
1994: Yasunori Morimoto; Kenji Sugibayashi; Hideshi Natsume
The transdermal drug delivery system and transcutaneous absorption.
Acta dermato-venereologica. Supplementum 1994;185():15-7.
1993: Ken-ichi Hosoya; H Kubo; Hideshi Natsume; Kenji Sugibayashi; Yasunori Morimoto; S Yamashita
The structural barrier of absorptive mucosae: site difference of the permeability of fluorescein isothiocyanate-labelled dextran in rabbits.
Biopharmaceutics & drug disposition 1993;14(8):685-95.
1993: S Numajiri; Kenji Sugibayashi; Yasunori Morimoto
Non-invasive sampling of lactic acid ions by iontophoresis using chloride ion in the body as an internal standard.
Journal of pharmaceutical and biomedical analysis 1993;11(10):903-9.
1993: S Numajiri; H Sakurai; Kenji Sugibayashi; Yasunori Morimoto; H Omiya; H Takenaka; N Akiyama
Comparison of depolarizing and direct current systems on iontophoretic enhancement of transport of sodium benzoate through human and hairless rat skin.
The Journal of pharmacy and pharmacology 1993;45(7):610-3.
1993: D Kobayashi; T Matsuzawa; Kenji Sugibayashi; Yasunori Morimoto; M Kobayashi; M Kimura
Feasibility of use of several cardiovascular agents in transdermal therapeutic systems with l-menthol-ethanol system on hairless rat and human skin.
Biological & pharmaceutical bulletin 1993;16(3):254-8.
1993: Hideshi Natsume; M Imamizu; Kenji Sugibayashi; T Shibata; A Miyagawa; Yasunori Morimoto
Selective accumulation and tumoricidal effect of cisplatin suspended in viscous ethyl oleate on hepatic cancers in animals after intraarterial infusion.
Journal of drug targeting 1993;1(3):207-15.
1992: Teruaki Hayashi; Kenji Sugibayashi; Yasunori Morimoto
Calculation of skin permeability coefficient for ionized and unionized species of indomethacin.
Chemical & pharmaceutical bulletin 1992;40(11):3090-3.
1992: Yasunori Morimoto; Tomomi Hatanaka; Kenji Sugibayashi; H Omiya
Prediction of skin permeability of drugs: comparison of human and hairless rat skin.
The Journal of pharmacy and pharmacology 1992;44(8):634-9.
1992: Hideshi Natsume; M Imamizu; Kenji Sugibayashi; T Shibata; A Miyagawa; Yasunori Morimoto
Oily drug carriers in cancer chemotherapy. II. Preparation of viscous ethyl oleate for intraarterial infusion therapy and its disposition in rats and hamsters.
Chemical & pharmaceutical bulletin 1992;40(6):1545-52.
1992: Kenji Sugibayashi; S Nakayama; Toshinobu Seki; Ken-ichi Hosoya; Yasunori Morimoto
Mechanism of skin penetration-enhancing effect by laurocapram.
Journal of pharmaceutical sciences 1992;81(1):58-64.
1991: T Hatanaka; M Oguchi; Kenji Sugibayashi; Yasunori Morimoto
Influence of isosorbide dinitrate concentration on its skin permeability from adhesive matrix devices.
Chemical & pharmaceutical bulletin 1991;39(7):1802-5.
1991: Hideshi Natsume; Kenji Sugibayashi; Yasunori Morimoto
In vitro release profile of mitomycin C from albumin microspheres: extrapolation from macrospheres to microspheres.
Pharmaceutical research 1991;8(2):185-90.
1991: K Sato; Kenji Sugibayashi; Yasunori Morimoto
Species differences in percutaneous absorption of nicorandil.
Journal of pharmaceutical sciences 1991;80(2):104-7.
1990: T Hatanaka; M Inuma; Kenji Sugibayashi; Yasunori Morimoto
Prediction of skin permeability of drugs. I. Comparison with artificial membrane.
Chemical & pharmaceutical bulletin 1990;38(12):3452-9.
1990: Toshinobu Seki; C Toeda; T Kawaguchi; Kazuhiko Juni; Kenji Sugibayashi; Yasunori Morimoto
Enhanced transdermal delivery of zidovudine in rats and human skin.
Chemical & pharmaceutical bulletin 1990;38(11):3086-9.
1990: Toshinobu Seki; T Kawaguchi; Kenji Sugibayashi; Kazuhiko Juni; Yasunori Morimoto
Membrane permeation-controlled transdermal delivery system design. Influence of controlling membrane and adhesive on skin permeation of isosorbide dinitrate.
Chemical & pharmaceutical bulletin 1990;38(3):740-3.
1989: K Sato; Kenji Sugibayashi; Yasunori Morimoto; H Omiya; N Enomoto
Prediction of the in-vitro human skin permeability of nicorandil from animal data.
The Journal of pharmacy and pharmacology 1989;41(6):379-83.
1989: Kenji Sugibayashi; C Sakanoue; Yasunori Morimoto
Utility of topical formulations of morphine hydrochloride containing azone and N-methyl-2-pyrrolidone.
Selective cancer therapeutics 1989;5(3):119-28.
1989: Toshinobu Seki; Kenji Sugibayashi; Kazuhiko Juni; Yasunori Morimoto
Percutaneous absorption enhancer applied to membrane permeation-controlled transdermal delivery of nicardipine hydrochloride.
Drug design and delivery 1989;4(1):69-75.
1987: Ken-ichi Hosoya; N Shudo; Kenji Sugibayashi; Yasunori Morimoto
Effect of Azone on the percutaneous absorption of 5-fluorouracil from gels in hairless rats.
Chemical & pharmaceutical bulletin 1987;35(2):726-33.
1985: Kenji Sugibayashi; Ken-ichi Hosoya; Yasunori Morimoto; W I Higuchi
Effect of the absorption enhancer, Azone, on the transport of 5-fluorouracil across hairless rat skin.
The Journal of pharmacy and pharmacology 1985;37(8):578-80.