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Giuseppina Bonanno

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Sergio Rutella; Giovanni Scambia; Michele Vacca; Annabella Procoli; Giuseppina Bonanno; Daniela Fioravanti; Maria Laura Foddai; Francesco Ipsevich; Paola Iudicone; Claudio Lavorino; Domenica Lorusso; Enrica Martinelli; Marianna Nuti; Luca Pierelli
Adoptive immunotherapy with cytokine-induced killer cells generated with a new good manufacturing practice-grade protocol.
Giuseppina Bonanno; Marilena Ciciarello; Raimondo De Cristofaro; Luca De Rosa; Valentina Folgiero; Manuela Gambella; Franco Locatelli; Ignazio Majolino; Andrea Mariotti; Daniela Natale; Linda Novarese; Antonio Palumbo; Annabella Procoli; Alberto Rocci; Giovanni Scambia; Sergio Rutella
Indoleamine 2,3-dioxygenase 1 (IDO1) activity correlates with immune system abnormalities in multiple myeloma.
Giuseppina Bonanno; Paola Iudicone; Andrea Mariotti; Annabella Procoli; Annino Pandolfi; Daniela Fioravanti; Maria Corallo; Alessandro Perillo; Giovanni Scambia; Luca Pierelli; Sergio Rutella
Thymoglobulin, interferon-γ and interleukin-2 efficiently expand cytokine-induced killer (CIK) cells in clinical-grade cultures.

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All Publications

2012: Sergio Rutella; Giovanni Scambia; Michele Vacca; Annabella Procoli; Giuseppina Bonanno; Daniela Fioravanti; Maria Laura Foddai; Francesco Ipsevich; Paola Iudicone; Claudio Lavorino; Domenica Lorusso; Enrica Martinelli; Marianna Nuti; Luca Pierelli
Adoptive immunotherapy with cytokine-induced killer cells generated with a new good manufacturing practice-grade protocol.
Cytotherapy 2012;14(7):841-50.
2012: Giuseppina Bonanno; Marilena Ciciarello; Raimondo De Cristofaro; Luca De Rosa; Valentina Folgiero; Manuela Gambella; Franco Locatelli; Ignazio Majolino; Andrea Mariotti; Daniela Natale; Linda Novarese; Antonio Palumbo; Annabella Procoli; Alberto Rocci; Giovanni Scambia; Sergio Rutella
Indoleamine 2,3-dioxygenase 1 (IDO1) activity correlates with immune system abnormalities in multiple myeloma.
Journal of translational medicine 2012;10():247.
2010: Giuseppina Bonanno; Paola Iudicone; Andrea Mariotti; Annabella Procoli; Annino Pandolfi; Daniela Fioravanti; Maria Corallo; Alessandro Perillo; Giovanni Scambia; Luca Pierelli; Sergio Rutella
Thymoglobulin, interferon-γ and interleukin-2 efficiently expand cytokine-induced killer (CIK) cells in clinical-grade cultures.
Journal of translational medicine 2010;8():129.
2010: Giuseppina Bonanno; Annabella Procoli; Andrea Mariotti; Maria Corallo; Alessandro Perillo; Silvio Danese; Raimondo De Cristofaro; Giovanni Scambia; Sergio Rutella
Effects of pegylated G-CSF on immune cell number and function in patients with gynecological malignancies.
Journal of translational medicine 2010;8():114.
2009: Sergio Rutella; Giuseppina Bonanno; Annabella Procoli; Andrea Mariotti; Maria Corallo; Maria Grazia Prisco; Adriana Eramo; Chiara Napoletano; Daniela Gallo; Alessandro Perillo; Marianna Nuti; Luca Pierelli; Ugo Testa; Giovanni Scambia; Gabriella Ferrandina
Cells with characteristics of cancer stem/progenitor cells express the CD133 antigen in human endometrial tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(13):4299-311.
2009: Sergio Rutella; Giuseppina Bonanno; Raimondo De Cristofaro
Targeting indoleamine 2,3-dioxygenase (IDO) to counteract tumour-induced immune dysfunction: from biochemistry to clinical development.
Endocrine, metabolic & immune disorders drug targets 2009;9(2):151-77.
2009: Giuseppina Bonanno; Andrea Mariotti; Annabella Procoli; Maria Corallo; Giovanni Scambia; Luca Pierelli; Sergio Rutella
Interleukin-21 induces the differentiation of human umbilical cord blood CD34-lineage- cells into pseudomature lytic NK cells.
BMC immunology 2009;10():46.
2008: Alessandro Perillo; Maria Corallo; Luigi Minafra; Giuseppina Bonanno; Daniela Visconti; Maria Serena Ligato; Giuseppe Fortunato; Giovanni Scambia; Salvatore Mancuso; Giuseppe Noia
The number, subset and source of cells injected remain critical factors affecting engraftment after in-utero stem cell transplantation via the intracelomic route.
European journal of obstetrics, gynecology, and reproductive biology 2008;138(2):248-9.
2008: Gabriella Ferrandina; Giuseppina Bonanno; Luca Pierelli; Alessandro Perillo; Annabella Procoli; Andrea Mariotti; M Corallo; E Martinelli; Sergio Rutella; Amelia Paglia; Gian Franco Zannoni; Salvatore Mancuso; Giovanni Scambia
Expression of CD133-1 and CD133-2 in ovarian cancer.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2008;18(3):506-14.
2008: Giuseppe Noia; Maria Serena Ligato; elena cesari; D Visconti; Giuseppe Fortunato; M Tintoni; I Mappa; C Greco; Maria Emiliana Caristo; Giuseppina Bonanno; M Corallo; L Minafra; Alessandro Perillo; Marinella Terzano; Sergio Rutella; Giuseppe Leone; Giovanni Scambia; M Michejda; Salvatore Mancuso
Source of cell injected is a critical factors for short and long engraftment in xeno-transplantation.
Cell proliferation 2008;41 Suppl 1():41-50.
2007: Antonio Curti; Simona Pandolfi; Barbara Valzasina; Michela Aluigi; Alessandro Isidori; Elisa Ferri; Valentina Salvestrini; Giuseppina Bonanno; Sergio Rutella; Ilaria Durelli; Alberto L Horenstein; Francesca Fiore; Massimo Massaia; Mario P Colombo; Michele Baccarani; Roberto M Lemoli
Modulation of tryptophan catabolism by human leukemic cells results in the conversion of CD25- into CD25+ T regulatory cells.
Blood 2007;109(7):2871-7.
2007: Giuseppina Bonanno; Andrea Mariotti; Annabella Procoli; Maria Corallo; Sergio Rutella; Gloria Pessina; Giovanni Scambia; Salvatore Mancuso; Luca Pierelli
Human cord blood CD133+ cells immunoselected by a clinical-grade apparatus differentiate in vitro into endothelial- and cardiomyocyte-like cells.
Transfusion 2007;47(2):280-9.
2006: Antonio Maria Leone; Sergio Rutella; Giuseppina Bonanno; Anna Maria Contemi; Daniela G De Ritis; Maria Benedetta Giannico; Antonio G Rebuzzi; Giuseppe Leone; Filippo Crea
Endogenous G-CSF and CD34+ cell mobilization after acute myocardial infarction.
International journal of cardiology 2006;111(2):202-8.
2006: Sergio Rutella; Giuseppina Bonanno; Annabella Procoli; Andrea Mariotti; Daniela G De Ritis; Antonio Curti; Silvio Danese; Gloria Pessina; Simona Pandolfi; Federica Natoni; Annalaura Di Febo; Giovanni Scambia; Rossella Manfredini; Simona Salati; Sergio Ferrari; Luca Pierelli; Giuseppe Leone; Roberto M Lemoli
Hepatocyte growth factor favors monocyte differentiation into regulatory interleukin (IL)-10++IL-12low/neg accessory cells with dendritic-cell features.
Blood 2006;108(1):218-27.
2006: Sergio Rutella; Giuseppina Bonanno; Annabella Procoli; Andrea Mariotti; M Barbara Lucia; Anna Maria Contemi; Roberto Cauda; Luana Fianchi; Giovanni Scambia; Livio Pagano; Giuseppe Leone
Granulocyte colony-stimulating factor enhances the in vitro cytotoxicity of gemtuzumab ozogamicin against acute myeloid leukemia cell lines and primary blast cells.
Experimental hematology 2006;34(1):54-65.
2005: Anna Chiara Piscaglia; Maria Assunta Zocco; Cristiana Di Campli; L Sparano; Sergio Rutella; Giovanni Monego; Giuseppina Bonanno; Fabrizio Michetti; Salvatore Mancuso; Paolo Pola; Giuseppe Leone; Giovanni Gasbarrini; antonio gasbarrini
How does human stem cell therapy influence gene expression after liver injury? Microarray evaluation on a rat model.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2005;37(12):952-63.
2005: Anna Chiara Piscaglia; Cristiana Di Campli; Maria Assunta Zocco; G Di Gioacchino; Marialuisa Novi; Sergio Rutella; Giuseppina Bonanno; Giovanni Monego; FM Vecchio; Fabrizio Michetti; Salvatore Mancuso; Giuseppe Leone; Giovanni Gasbarrini; Paolo Pola; antonio gasbarrini
Human cordonal stem cell intraperitoneal injection can represent a rescue therapy after an acute hepatic damage in immunocompetent rats.
Transplantation proceedings 2005;37(6):2711-4.
2005: Cristiana Di Campli; Anna Chiara Piscaglia; Sergio Rutella; Giuseppina Bonanno; FM Vecchio; Maria Assunta Zocco; Giovanni Monego; Fabrizio Michetti; Salvatore Mancuso; Paolo Pola; Giuseppe Leone; Giovanni Gasbarrini; antonio gasbarrini
Improvement of mortality rate and decrease in histologic hepatic injury after human cord blood stem cell infusion in a murine model of hepatotoxicity.
Transplantation proceedings 2005;37(6):2707-10.
2005: Cristiana Di Campli; Anna Chiara Piscaglia; FELICE GIULIANTE; Sergio Rutella; Giuseppina Bonanno; Maria Assunta Zocco; Francesco Ardito; Gennaro Nuzzo; Salvatore Mancuso; Giuseppe Leone; Giovanni Gasbarrini; Paolo Pola; antonio gasbarrini
No evidence of hematopoietic stem cell mobilization in patients submitted to hepatectomy or in patients with acute on chronic liver failure.
Transplantation proceedings 2005;37(6):2563-6.
2005: Antonio Maria Leone; Sergio Rutella; Giuseppina Bonanno; Antonio Abbate; Antonio G Rebuzzi; Silvia Giovannini; Mariaelena Lombardi; Leonarda Galiuto; Giovanna Liuzzo; Felicita Andreotti; Gaetano Antonio Lanza; Anna Maria Contemi; Giuseppe Leone; Filippo Crea
Mobilization of bone marrow-derived stem cells after myocardial infarction and left ventricular function.
European heart journal 2005;26(12):1196-204.
2005: Alessandro Perillo; Gabriella Ferrandina; Luca Pierelli; Giuseppina Bonanno; Giovanni Scambia; Salvatore Mancuso
Stem cell-based treatments for gynecological solid tumors.
European review for medical and pharmacological sciences 2005;9(2):93-102.
2005: Paolo Turrini; Giovanni Monego; Josè Gonzalez; Sandra Cicuzza; Giuseppina Bonanno; Giovanni Zelano; Nadia Rosenthal; Giacomo Paonessa; Ralph Laufer; Julio Padron
Human hepatocytes in mice receiving pre-immune injection with human cord blood cells.
Biochemical and biophysical research communications 2005;326(1):66-73.
2004: Cristiana Di Campli; Anna Chiara Piscaglia; Luca Pierelli; Sergio Rutella; Giuseppina Bonanno; M R Alison; A Mariotti; FM Vecchio; Manuela Nestola; Giovanni Monego; Fabrizio Michetti; Salvatore Mancuso; Paolo Pola; Giuseppe Leone; Giovanni Gasbarrini; antonio gasbarrini
A human umbilical cord stem cell rescue therapy in a murine model of toxic liver injury.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2004;36(9):603-13.
2004: Giuseppina Bonanno; Alessandro Perillo; Sergio Rutella; Daniela Giovanna De Ritis; Andrea Mariotti; Maria Marone; Franco Meoni; Giovanni Scambia; Giuseppe Leone; Salvatore Mancuso; Luca Pierelli
Clinical isolation and functional characterization of cord blood CD133+ hematopoietic progenitor cells.
Transfusion 2004;44(7):1087-97.
2004: Sergio Rutella; Giuseppina Bonanno; Luca Pierelli; Andrea Mariotti; Ettore Capoluongo; Anna Maria Contemi; Franco Ameglio; Antonio Curti; Daniela G De Ritis; Maria Teresa Voso; Alessandro Perillo; Salvatore Mancuso; Giovanni Scambia; Roberto M Lemoli; Giuseppe Leone
Granulocyte colony-stimulating factor promotes the generation of regulatory DC through induction of IL-10 and IFN-alpha.
European journal of immunology 2004;34(5):1291-302.
2004: Alessandro Perillo; Giuseppina Bonanno; Luca Pierelli; Sergio Rutella; Giovanni Scambia; Salvatore Mancuso
Stem cells in gynecology and obstetrics.
Panminerva medica 2004;46(1):49-59.
2004: Giuseppe Noia; Luca Pierelli; Giuseppina Bonanno; Giovanni Monego; Alessandro Perillo; Sergio Rutella; Anna Franca Cavaliere; Giuseppe Straface; Giuseppe Fortunato; elena cesari; Giovanni Scambia; Marinella Terzano; Enrico Iannace; Giovanni Zelano; Fabrizio Michetti; Giuseppe Leone; Salvatore Mancuso
The intracoelomic route: a new approach for in utero human cord blood stem cell transplantation.
Fetal diagnosis and therapy 2004;19(1):13-22.
2003: Sergio Rutella; Giuseppina Bonanno; Maria Marone; Daniela G De Ritis; Andrea Mariotti; Maria Teresa Voso; Giovanni Scambia; Salvatore Mancuso; Giuseppe Leone; Luca Pierelli
Identification of a novel subpopulation of human cord blood CD34-CD133-CD7-CD45+lineage- cells capable of lymphoid/NK cell differentiation after in vitro exposure to IL-15.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(6):2977-88.
2003: Giuseppe Noia; Luca Pierelli; Giuseppina Bonanno; Giovanni Monego; Alessandro Perillo; Sergio Rutella; Anna Franca Cavaliere; Marco De Santis; Maria Serena Ligato; Giuseppe Fortunato; Giovanni Scambia; Giuseppina Maria Terzano; Enrico Iannace; Giovanni Zelano; Fabrizio Michetti; Giuseppe Leone; Salvatore Mancuso; Marinela Terzano; Giuseppe Fotunato
A novel route of transplantation of human cord blood stem cells in preimmune fetal sheep: the intracelomic cavity.
Stem cells (Dayton, Ohio) 2003;21(6):638-46.
2002: Sergio Rutella; Luca Pierelli; Giuseppina Bonanno; Simona Sica; Franco Ameglio; Ettore Capoluongo; Andrea Mariotti; Giovanni Scambia; Giuseppe d'Onofrio; Giuseppe Leone
Role for granulocyte colony-stimulating factor in the generation of human T regulatory type 1 cells.
Blood 2002;100(7):2562-71.
2002: Luca Pierelli; Maria Marone; Giuseppina Bonanno; Sergio Rutella; Daniela G De Ritis; Salvatore Mancuso; Giuseppe Leone; Giovanni Scambia
Transforming growth factor-beta1 causes transcriptional activation of CD34 and preserves haematopoietic stem/progenitor cell activity.
British journal of haematology 2002;118(2):627-37.
2002: Maria Marone; Daniela G De Ritis; Giuseppina Bonanno; Simona Mozzetti; Sergio Rutella; Giovanni Scambia; Luca Pierelli
Cell cycle regulation in human hematopoietic stem cells: from isolation to activation.
Leukemia & lymphoma 2002;43(3):493-501.
2002: Maria Marone; Giuseppina Bonanno; Sergio Rutella; Giuseppe Leone; Giovanni Scambia; Luca Pierelli
Survival and cell cycle control in early hematopoiesis: role of bcl-2, and the cyclin dependent kinase inhibitors P27 and P21.
Leukemia & lymphoma 2002;43(1):51-7.
2001: Sergio Rutella; Luca Pierelli; Giuseppina Bonanno; Andrea Mariotti; Simona Sica; Federica Sorà; Patrizia Chiusolo; Giovanni Scambia; Carlo Rumi; Giuseppe Leone
Immune reconstitution after autologous peripheral blood progenitor cell transplantation: effect of interleukin-15 on T-cell survival and effector functions.
Experimental hematology 2001;29(12):1503-16.
2001: Luca Pierelli; Giuseppina Bonanno; Sergio Rutella; Maria Marone; G Scambia; G Leone
CD105 (endoglin) expression on hematopoietic stem/progenitor cells.
Leukemia & lymphoma 2001;42(6):1195-206.
2001: Alessandro Perillo; Luca Pierelli; G Scambia; Riccardo Serafini; U Paladini; M G Salerno; Giuseppina Bonanno; Andrea Fattorossi; Giuseppe Leone; Salvatore Mancuso; G Menichella
Peripheral blood progenitor cell collection after epirubicin, paclitaxel, and cisplatin combination chemotherapy using EPO-based cytokine regimens: a randomized comparison of G-CSF and sequential GM-/G-CSF.
Transfusion 2001;41(5):674-80.
2001: Sergio Rutella; Luca Pierelli; Carlo Rumi; Giuseppina Bonanno; Maria Marone; Simona Sica; Ettore Capoluongo; F Ameglio; Giovanni Scambia; Giuseppe Leone
T-cell apoptosis induced by granulocyte colony-stimulating factor is associated with retinoblastoma protein phosphorylation and reduced expression of cyclin-dependent kinase inhibitors.
Experimental hematology 2001;29(4):401-15.
2000: Sergio Rutella; Giuseppina Bonanno; Luca Pierelli; Federica Sorà; Simona Sica; Giovanni Scambia; G d'Onofrio; Carlo Rumi; Giuseppe Leone
Enhanced susceptibility to apoptosis in T cells recovering after autologous peripheral blood progenitor cell transplantation: reversal by interleukin-15.
Cytokines, cellular & molecular therapy 2000;6(4):189-98.
2000: Maria Marone; Luca Pierelli; Simona Mozzetti; Valeria Masciullo; Giuseppina Bonanno; Roberta Morosetti; Sergio Rutella; Alessandra Battaglia; Carlo Rumi; Salvatore Mancuso; Giuseppe Leone; Antonio Giordano; Giovanni Scambia
High cyclin-dependent kinase inhibitors in Bcl-2 and Bcl-xL-expressing CD34+-proliferating haematopoietic progenitors.
British journal of haematology 2000;110(3):654-62.
2000: Sergio Rutella; Carlo Rumi; Luca Pierelli; Roberta Morosetti; Simona Sica; Giuseppina Bonanno; Giovanni Scambia; Giuseppe Leone
Granulocyte colony-stimulating factor perturbs lymphocyte mitochondrial function and inhibits cell cycle progression.
Experimental hematology 2000;28(6):612-25.
2000: Luca Pierelli; Maria Marone; Giuseppina Bonanno; Simona Mozzetti; Sergio Rutella; Roberta Morosetti; Carlo Rumi; Salvatore Mancuso; Giuseppe Leone; Giovanni Scambia
Modulation of bcl-2 and p27 in human primitive proliferating hematopoietic progenitors by autocrine TGF-beta1 is a cell cycle-independent effect and influences their hematopoietic potential.
Blood 2000;95(10):3001-9.
2000: Alessandra Battaglia; Andrea Fattorossi; Luca Pierelli; Giuseppina Bonanno; Maria Marone; Franco O Ranelletti; Annamaria Coscarella; Rita De Santis; S Bach; S Mancuso; Giovanni Scambia
The fusion protein MEN 11303 (granulocyte-macrophage colony stimulating factor/erythropoietin) acts as a potent inducer of erythropoiesis.
Experimental hematology 2000;28(5):490-8.
2000: Luca Pierelli; Giovanni Scambia; Giuseppina Bonanno; Sergio Rutella; Pierluigi Puggioni; Alessandra Battaglia; Simona Mozzetti; Maria Marone; G Menichella; Carlo Rumi; Salvatore Mancuso; Giuseppe Leone
CD34+/CD105+ cells are enriched in primitive circulating progenitors residing in the G0 phase of the cell cycle and contain all bone marrow and cord blood CD34+/CD38low/- precursors.
British journal of haematology 2000;108(3):610-20.
1999: Luca Pierelli; Giovanni Scambia; Giuseppina Bonanno; Annamaria Coscarella; Rita De Santis; Alfonso Mele; Alessandra Battaglia; Andrea Fattorossi; V Romeo; G Menichella; S Mancuso; Giuseppe Leone
Expansion of granulocyte colony-stimulating factor/chemotherapy-mobilized CD34+ hematopoietic progenitors: role of granulocyte-macrophage colony-stimulating factor/erythropoietin hybrid protein (MEN11303) and interleukin-15.
Experimental hematology 1999;27(3):416-24.
1998: Luca Pierelli; G Scambia; Andrea Fattorossi; Giuseppina Bonanno; A Battaglia; Alessandro Perillo; G Menichella; P B Panici; G Leone; S Mancuso
In vitro effect of amifostine on haematopoietic progenitors exposed to carboplatin and non-alkylating antineoplastic drugs: haematoprotection acts as a drug-specific progenitor rescue.
British journal of cancer 1998;78(8):1024-9.
1998: Luca Pierelli; Giovanni Scambia; Andrea Fattorossi; Giuseppina Bonanno; Alessandra Battaglia; Carlo Rumi; Maria Marone; Simona Mozzetti; Sergio Rutella; G Menichella; V Romeo; Salvatore Mancuso; Giuseppe Leone
Functional, phenotypic and molecular characterization of cytokine low-responding circulating CD34+ haemopoietic progenitors.
British journal of haematology 1998;102(5):1139-50.
1997: Luca Pierelli; Giovanni Scambia; G d'Onofrio; M Ciarli; Andrea Fattorossi; Giuseppina Bonanno; G Menichella; Alessandra Battaglia; Pierluigi Benedetti Panici; M Tommasi; S Mancuso; Giuseppe Leone
Generation of multinuclear tartrate-resistant acid phosphatase positive osteoclasts in liquid culture of purified human peripheral blood CD34+ progenitors.
British journal of haematology 1997;96(1):64-9.
1997: Luca Pierelli; Giovanni Scambia; G Menichella; Andrea Fattorossi; M Ciarli; Giuseppina Bonanno; Alessandra Battaglia; G d'Onofrio; Pierluigi Benedetti Panici; A Iacone; S Mancuso; Giuseppe Leone
Purified unfractionated G-CSF/chemotherapy mobilized CD34+ peripheral blood progenitors and not bone marrow CD34+ progenitors undergo selective erythroid differentiation in liquid culture in the presence of erythropoietin and stem cell factor.
British journal of haematology 1997;96(1):55-63.