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Takashi Sugimura

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Masafumi Yamamoto; Masahiko Watanabe; Shigeo Imanishi; Yuko Matsushima-Hibiya; Jun Mitsuhashi; Hitoshi Nakagama; Tsuyoshi Nakano; Takashi Sugimura; Azusa Takahashi-Nakaguchi; Yukari Totsuka; Keiji Wakabayashi
Nucleotide sequence and chromosomal localization of the gene for pierisin-1, a DNA ADP-ribosylating protein, in the cabbage butterfly Pieris rapae.
Hideki Ogino; Robert Nakayama; Hiromi Sakamoto; Teruhiko Yoshida; Takashi Sugimura; Mitsuko Masutani
Analysis of poly(ADP-ribose) polymerase-1 (PARP1) gene alteration in human germ cell tumor cell lines.
H Fujihara; H Ogino; D Maeda; H Shirai; T Nozaki; N Kamada; Kou-ichi Jishage; S Tanuma; Tsuyoshi Takato; Takahiro Ochiya; Takashi Sugimura; Mitsuko Masutani
Poly(ADP-ribose) Glycohydrolase deficiency sensitizes mouse ES cells to DNA damaging agents.

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All Publications

2011: Masafumi Yamamoto; Masahiko Watanabe; Shigeo Imanishi; Yuko Matsushima-Hibiya; Jun Mitsuhashi; Hitoshi Nakagama; Tsuyoshi Nakano; Takashi Sugimura; Azusa Takahashi-Nakaguchi; Yukari Totsuka; Keiji Wakabayashi
Nucleotide sequence and chromosomal localization of the gene for pierisin-1, a DNA ADP-ribosylating protein, in the cabbage butterfly Pieris rapae.
Genetica 2011;139(10):1251-8.
2010: Hideki Ogino; Robert Nakayama; Hiromi Sakamoto; Teruhiko Yoshida; Takashi Sugimura; Mitsuko Masutani
Analysis of poly(ADP-ribose) polymerase-1 (PARP1) gene alteration in human germ cell tumor cell lines.
Cancer genetics and cytogenetics 2010;197(1):8-15.
2009: H Fujihara; H Ogino; D Maeda; H Shirai; T Nozaki; N Kamada; Kou-ichi Jishage; S Tanuma; Tsuyoshi Takato; Takahiro Ochiya; Takashi Sugimura; Mitsuko Masutani
Poly(ADP-ribose) Glycohydrolase deficiency sensitizes mouse ES cells to DNA damaging agents.
Current cancer drug targets 2009;9(8):953-62.
2009: Atsushi Shibata; Daisuke Maeda; Hideki Ogino; Masahiro Tsutsumi; Takehiko Nohmi; Hitoshi Nakagama; Takashi Sugimura; Hirobumi Teraoka; Mitsuko Masutani
Role of Parp-1 in suppressing spontaneous deletion mutation in the liver and brain of mice at adolescence and advanced age.
Mutation research 2009;664(1-2):20-7.
2008: Katsuhiro Fukuta; Kenjiro Kohri; Hirokazu Fukuda; Masatoshi Watanabe; Takashi Sugimura; Hitoshi Nakagama
Induction of multinucleated cells and apoptosis in the PC-3 prostate cancer cell line by low concentrations of polyethylene glycol 1000.
Cancer science 2008;99(5):1055-62.
2007: Naoto Tsuchiya; Masako Ochiai; Katsuhiko Nakashima; Tsuneyuki Ubagai; Takashi Sugimura; Hitoshi Nakagama
SND1, a component of RNA-induced silencing complex, is up-regulated in human colon cancers and implicated in early stage colon carcinogenesis.
Cancer research 2007;67(19):9568-76.
2007: Masako Nakanishi; Hiroshi Tazawa; Naoto Tsuchiya; Takashi Sugimura; Takuji Tanaka; Hitoshi Nakagama
Mouse strain differences in inflammatory responses of colonic mucosa induced by dextran sulfate sodium cause differential susceptibility to PhIP-induced large bowel carcinogenesis.
Cancer science 2007;98(8):1157-63.
2006: Takeshi Nakajima; Takao Maekita; Ichiro Oda; Takuji Gotoda; Seiichiro Yamamoto; Satoshi Umemura; Masao Ichinose; Takashi Sugimura; Toshikazu Ushijima; Daizo Saito
Higher methylation levels in gastric mucosae significantly correlate with higher risk of gastric cancers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2006;15(11):2317-21.
2006: Mami Mihara; Yukinari Yoshida; Tetsuya Tsukamoto; Ken-ichi Inada; Yukihiro Nakanishi; Yukiko Yagi; Kohzoh Imai; Takashi Sugimura; Masae Tatematsu; Toshikazu Ushijima
Methylation of multiple genes in gastric glands with intestinal metaplasia: A disorder with polyclonal origins.
The American journal of pathology 2006;169(5):1643-51.
2006: Akemi Gunji; Akiko Uemura; Masahiro Tsutsumi; Tadashige Nozaki; Osamu Kusuoka; Ken Omura; Hiroshi Suzuki; Hitoshi Nakagama; Takashi Sugimura; Mitsuko Masutani
Parp-1 deficiency does not increase the frequency of tumors in the oral cavity and esophagus of ICR/129Sv mice by 4-nitroquinoline 1-oxide, a carcinogen producing bulky adducts.
Cancer letters 2006;241(1):87-92.
2006: Takashi Sugimura
Congratulatory dedication to Professor Osamu Hayaishi: from Bethesda to Ueno Park (Japan Academy).
IUBMB life 2006;58(5-6):251-2.
2006: Takao Maekita; Kazuyuki Nakazawa; Mami Mihara; Takeshi Nakajima; Kimihiko Yanaoka; Mikitaka Iguchi; Kenji Arii; Atsushi Kaneda; Tetsuya Tsukamoto; Masae Tatematsu; Gen Tamura; Daizo Saito; Takashi Sugimura; Masao Ichinose; Toshikazu Ushijima
High levels of aberrant DNA methylation in Helicobacter pylori-infected gastric mucosae and its possible association with gastric cancer risk.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(3 Pt 1):989-95.
2005: Kazuaki Miyamoto; Takashi Fukutomi; Sadako Akashi-Tanaka; Tadashi Hasegawa; Toshimasa Asahara; Takashi Sugimura; Toshikazu Ushijima
Identification of 20 genes aberrantly methylated in human breast cancers.
International journal of cancer. Journal international du cancer 2005;116(3):407-14.
2005: Tohru Niwa; Satoshi Yamashita; Tetsuya Tsukamoto; Takashi Kuramoto; Tomoko Nomoto; Kuniko Wakazono; Hirofumi Fujita; Taijiro Matsushima; Masae Tatematsu; Takashi Sugimura; Toshikazu Ushijima
Whole-genome analyses of loss of heterozygosity and methylation analysis of four tumor-suppressor genes in N-methyl-N'-nitro-N-nitrosoguanidine-induced rat stomach carcinomas.
Cancer science 2005;96(7):409-13.
2005: Mitsuko Masutani; Hitoshi Nakagama; Takashi Sugimura
Poly(ADP-ribosyl)ation in relation to cancer and autoimmune disease.
Cellular and molecular life sciences : CMLS 2005;62(7-8):769-83.
2005: Satoshi Yamashita; Shugo Suzuki; Tomoko Nomoto; Yasushi Kondo; Kuniko Wakazono; Yoshimi Tsujino; Takashi Sugimura; Tomoyuki Shirai; Yukio Homma; Toshikazu Ushijima
Linkage and microarray analyses of susceptibility genes in ACI/Seg rats: a model for prostate cancers in the aged.
Cancer research 2005;65(7):2610-6.
2005: Masako Ochiai; Masatoshi Watanabe; Masako Nakanishi; Ayako Taguchi; Takashi Sugimura; Hitoshi Nakagama
Differential staining of dysplastic aberrant crypt foci in the colon facilitates prediction of carcinogenic potentials of chemicals in rats.
Cancer letters 2005;220(1):67-74.
2005: Mitsunori Ushigome; Tsuneyuki Ubagai; Hirokazu Fukuda; Naoto Tsuchiya; Takashi Sugimura; Jun Takatsuka; Hitoshi Nakagama
Up-regulation of hnRNP A1 gene in sporadic human colorectal cancers.
International journal of oncology 2005;26(3):635-40.
2005: Atsushi Shibata; Nobuo Kamada; Ken-Ichi Masumura; Takehiko Nohmi; Shizuko Kobayashi; Hirobumi Teraoka; Hitoshi Nakagama; Takashi Sugimura; Hiroshi Suzuki; Mitsuko Masutani
Parp-1 deficiency causes an increase of deletion mutations and insertions/rearrangements in vivo after treatment with an alkylating agent.
Oncogene 2005;24(8):1328-37.
2005: Junichi Furuta; Atsushi Kaneda; Yoshihiro Umebayashi; Fujio Otsuka; Takashi Sugimura; Toshikazu Ushijima
Silencing of the thrombomodulin gene in human malignant melanoma.
Melanoma research 2005;15(1):15-20.
2005: Motoko Shiokawa; Mitsuko Masutani; Hisako Fujihara; Keisuke Ueki; Ryo Nishikawa; Takashi Sugimura; Harumi Kubo; Hitoshi Nakagama
Genetic alteration of poly(ADP-ribose) polymerase-1 in human germ cell tumors.
Japanese journal of clinical oncology 2005;35(2):97-102.
2005: Toshikazu Ushijima; Naoko Watanabe; Kimiko Shimizu; Kazuaki Miyamoto; Takashi Sugimura; Atsushi Kaneda
Decreased fidelity in replicating CpG methylation patterns in cancer cells.
Cancer research 2005;65(1):11-7.
2005: Masako Ochiai; Takashi Sugimura; Minako Nagao
Modification of the 32P-postlabeling method to detect a single adduct species as a single spot.
Methods in molecular biology (Clifton, N.J.) 2005;291():13-9.
2004: Eriko Okochi-Takada; Shizue Ichimura; Atsushi Kaneda; Takashi Sugimura; Toshikazu Ushijima
Establishment of a detection system for demethylating agents using an endogenous promoter CpG island.
Mutation research 2004;568(2):187-94.
2004: Junichi Furuta; Yoshihiro Umebayashi; Kazuaki Miyamoto; Kanako Kikuchi; Fujio Otsuka; Takashi Sugimura; Toshikazu Ushijima
Promoter methylation profiling of 30 genes in human malignant melanoma.
Cancer science 2004;95(12):962-8.
2004: Atsushi Hagihara; Kazuaki Miyamoto; Junichi Furuta; Nobuyoshi Hiraoka; Kuniko Wakazono; Shuichi Seki; Shoji Fukushima; Ming Tsao; Takashi Sugimura; Toshikazu Ushijima
Identification of 27 5' CpG islands aberrantly methylated and 13 genes silenced in human pancreatic cancers.
Oncogene 2004;23(53):8705-10.
2004: Atsushi Kaneda; Kuniko Wakazono; Tetsuya Tsukamoto; Naoko Watanabe; Yukiko Yagi; Masae Tatematsu; Michio Kaminishi; Takashi Sugimura; Toshikazu Ushijima
Lysyl oxidase is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in human gastric cancers.
Cancer research 2004;64(18):6410-5.
2004: Kyoko Fujiwara; Masako Ochiai; Tsutomu Ohta; Misao Ohki; Hiroyuki Aburatani; Minako Nagao; Takashi Sugimura; Hitoshi Nakagama
Global gene expression analysis of rat colon cancers induced by a food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Carcinogenesis 2004;25(8):1495-505.
2004: Satoshi Yamashita; Tomoko Nomoto; Masanobu Abe; Masae Tatematsu; Takashi Sugimura; Toshikazu Ushijima
Persistence of gene expression changes in stomach mucosae induced by short-term N-methyl-N'-nitro-N-nitrosoguanidine treatment and their presence in stomach cancers.
Mutation research 2004;549(1-2):185-93.
2004: Naoto Tsuchiya; Hirokazu Fukuda; Katsuhiko Nakashima; Minako Nagao; Takashi Sugimura; Hitoshi Nakagama
LRP130, a single-stranded DNA/RNA-binding protein, localizes at the outer nuclear and endoplasmic reticulum membrane, and interacts with mRNA in vivo.
Biochemical and biophysical research communications 2004;317(3):736-43.
2004: Takashi Sugimura; Keiji Wakabayashi; Hitoshi Nakagama; Minako Nagao
Heterocyclic amines: Mutagens/carcinogens produced during cooking of meat and fish.
Cancer science 2004;95(4):290-9.
2003: Satoshi Yamashita; Tomoko Nomoto; Tsutomu Ohta; Misao Ohki; Takashi Sugimura; Toshikazu Ushijima
Differential expression of genes related to levels of mucosal cell proliferation among multiple rat strains by using oligonucleotide microarrays.
Mammalian genome : official journal of the International Mammalian Genome Society 2003;14(12):845-52.
2003: Mitsuko Masutani; Hitoshi Nakagama; Takashi Sugimura
Poly(ADP-ribose) and carcinogenesis.
Genes, chromosomes & cancer 2003;38(4):339-48.
2003: Masako Ochiai; Mitsunori Ushigome; Kyoko Fujiwara; Tsuneyuki Ubagai; Toshihiko Kawamori; Takashi Sugimura; Minako Nagao; Hitoshi Nakagama
Characterization of dysplastic aberrant crypt foci in the rat colon induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
The American journal of pathology 2003;163(4):1607-14.
2003: Kyoko Fujiwara; Masako Ochiai; Tsuneyuki Ubagai; Misao Ohki; Tsutomu Ohta; Minako Nagao; Takashi Sugimura; Hitoshi Nakagama
Differential gene expression profiles in colon epithelium of two rat strains with distinct susceptibility to colon carcinogenesis after exposure to PhIP in combination with dietary high fat.
Cancer science 2003;94(8):672-8.
2003: Tadashige Nozaki; Hisako Fujihara; Masatoshi Watanabe; Masahiro Tsutsumi; Kentaro Nakamoto; Osamu Kusuoka; Nobuo Kamada; Hiroshi Suzuki; Hitoshi Nakagama; Takashi Sugimura; Mitsuko Masutani
Parp-1 deficiency implicated in colon and liver tumorigenesis induced by azoxymethane.
Cancer science 2003;94(6):497-500.
2003: Masanobu Abe; Satoshi Yamashita; Takashi Kuramoto; Yoshikazu Hirayama; Tetsuya Tsukamoto; Tsutomu Ohta; Masae Tatematsu; Misao Ohki; Tsuyoshi Takato; Takashi Sugimura; Toshikazu Ushijima
Global expression analysis of N-methyl-N'-nitro-N-nitrosoguanidine-induced rat stomach carcinomas using oligonucleotide microarrays.
Carcinogenesis 2003;24(5):861-7.
2003: Toshikazu Ushijima; Naoko Watanabe; Eriko Okochi; Atsushi Kaneda; Takashi Sugimura; Kazuaki Miyamoto
Fidelity of the methylation pattern and its variation in the genome.
Genome research 2003;13(5):868-74.
2003: Naotaka Torii; Tadashige Nozaki; Mitsuko Masutani; Hitoshi Nakagama; Toshiro Sugiyama; Daizo Saito; Masahiro Asaka; Takashi Sugimura; Kazumasa Miki
Spontaneous mutations in the Helicobacter pylori rpsL gene.
Mutation research 2003;535(2):141-5.
2003: Yoshiaki Enokizono; Akimasa Matsugami; Seiichi Uesugi; Hirokazu Fukuda; Naoto Tsuchiya; Takashi Sugimura; Minako Nagao; Hitoshi Nakagama; Masato Katahira
Destruction of quadruplex by proteins, and its biological implications in replication and telomere maintenance.
Nucleic acids research. Supplement (2001) 2003;(3):231-2.
2003: Atsushi Shibata; Mitsuko Masutani; Tadashige Nozaki; Nobuo Kamada; H Fujihara; Ken-Ichi Masumura; Hitoshi Nakagama; Takashi Sugimura; Shizuko Kobayashi; Hiroshi Suzuki; Takehiko Nohmi
Improvement of the Spi- assay for mutations in gpt delta mice by including magnesium ions during plaque formation.
Environmental and molecular mutagenesis 2003;41(5):370-2.
2003: Kiyoshi Asada; Kazuaki Miyamoto; Takashi Fukutomi; Hitoshi Tsuda; Yukiko Yagi; Kuniko Wakazono; Shoko Oishi; Hiroshi Fukui; Takashi Sugimura; Toshikazu Ushijima
Reduced expression of GNA11 and silencing of MCT1 in human breast cancers.
Oncology 2003;64(4):380-8.
2002: Takashi Sugimura
Food and cancer.
Toxicology 2002;181-182():17-21.
2002: Atsushi Kaneda; Michio Kaminishi; Kazuyoshi Yanagihara; Takashi Sugimura; Toshikazu Ushijima
Identification of silencing of nine genes in human gastric cancers.
Cancer research 2002;62(22):6645-50.
2002: Masanobu Abe; Eriko Okochi; Takashi Kuramoto; Atsushi Kaneda; Tsuyoshi Takato; Takashi Sugimura; Toshikazu Ushijima
Cloning of the 5' upstream region of the rat p16 gene and its role in silencing.
Japanese journal of cancer research : Gann 2002;93(10):1100-6.
2002: Hirokazu Fukuda; Masato Katahira; Naoto Tsuchiya; Yoshiaki Enokizono; Takashi Sugimura; Minako Nagao; Hitoshi Nakagama
Unfolding of quadruplex structure in the G-rich strand of the minisatellite repeat by the binding protein UP1.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(20):12685-90.
2002: Hitoshi Nakagama; Masako Ochiai; Tsuneyuki Ubagai; Rie Tajima; Kyoko Fujiwara; Takashi Sugimura; Minako Nagao
A rat colon cancer model induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, PhIP.
Mutation research 2002;506-507():137-44.
2002: Eriko Okochi; Naoko Watanabe; Takashi Sugimura; Toshikazu Ushijima
Single nucleotide instability: a wide involvement in human and rat mammary carcinogenesis?
Mutation research 2002;506-507():101-11.
2002: Pratik Multani; Kensei Tobinai; Tadao Kakizoe; James O Armitage; Ryuzo Ohno; Takashi Sugimura
Report of the fifteenth international symposium of the foundation for promotion of cancer research: new horizons in the diagnosis and treatment of hematological malignancies based on molecular genetic features.
Japanese journal of clinical oncology 2002;32(9):371-85.
2002: Eriko Okochi; Kazuaki Miyamoto; Kuniko Wakazono; Hiroshi Shima; Takashi Sugimura; Toshikazu Ushijima
Reduced Brca1 protein expression in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced rat mammary carcinomas.
Molecular carcinogenesis 2002;34(4):211-8.
2002: Atsushi Kaneda; Michio Kaminishi; Yukihiro Nakanishi; Takashi Sugimura; Toshikazu Ushijima
Reduced expression of the insulin-induced protein 1 and p41 Arp2/3 complex genes in human gastric cancers.
International journal of cancer. Journal international du cancer 2002;100(1):57-62.
2002: Takashi Kuramoto; Keiichirou Morimura; Satoshi Yamashita; Eriko Okochi; Naoko Watanabe; Tsutomu Ohta; Misao Ohki; Shoji Fukushima; Takashi Sugimura; Toshikazu Ushijima
Etiology-specific gene expression profiles in rat mammary carcinomas.
Cancer research 2002;62(13):3592-7.
2002: Satoshi Yamashita; Kuniko Wakazono; Takashi Sugimura; Toshikazu Ushijima
Profiling and selection of genes differentially expressed in the pylorus of rat strains with different proliferative responses and stomach cancer susceptibility.
Carcinogenesis 2002;23(6):923-8.
2002: Naoto Tsuchiya; Hirokazu Fukuda; Takashi Sugimura; Minako Nagao; Hitoshi Nakagama
LRP130, a protein containing nine pentatricopeptide repeat motifs, interacts with a single-stranded cytosine-rich sequence of mouse hypervariable minisatellite Pc-1.
European journal of biochemistry / FEBS 2002;269(12):2927-33.
2002: Eriko Okochi; Shizue Ichimura; Takashi Sugimura; Toshikazu Ushijima
The absence of Mth1 inactivation and DNA polymerase kappa overexpression in rat mammary carcinomas with frequent A:T to C:G transversions.
Japanese journal of cancer research : Gann 2002;93(5):501-6.
2002: Masako Ochiai; Hiroshi Imai; Takashi Sugimura; Minako Nagao; Hitoshi Nakagama
Induction of intestinal tumors and lymphomas in C57BL/6N mice by a food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Japanese journal of cancer research : Gann 2002;93(5):478-83.
2002: Hideaki Inamori; Sachiyo Takagi; Rie Tajima; Masako Ochiai; Tsuneyuki Ubagai; Takashi Sugimura; Minako Nagao; Hitoshi Nakagama
Frequent and multiple mutations at minisatellite loci in sporadic human colorectal and gastric cancers--possible mechanistic differences from microsatellite instability in cancer cells.
Japanese journal of cancer research : Gann 2002;93(4):382-8.
2002: Kazuaki Miyamoto; Takashi Fukutomi; Kiyoshi Asada; Kuniko Wakazono; Hitoshi Tsuda; Toshimasa Asahara; Takashi Sugimura; Toshikazu Ushijima
Promoter hypermethylation and post-transcriptional mechanisms for reduced BRCA1 immunoreactivity in sporadic human breast cancers.
Japanese journal of clinical oncology 2002;32(3):79-84.
2002: Minako Nagao; Toshikazu Ushijima; Naoko Watanabe; Eriko Okochi; Masako Ochiai; Hitoshi Nakagama; Takashi Sugimura
Studies on mammary carcinogenesis induced by a heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, in mice and rats.
Environmental and molecular mutagenesis 2002;39(2-3):158-64.
2002: Takashi Kuramoto; Tomoko Nomoto; Akira Fujiwara; Makoto Mizutani; Takashi Sugimura; Toshikazu Ushijima
Insertional mutation of the Attractin gene in the black tremor hamster.
Mammalian genome : official journal of the International Mammalian Genome Society 2002;13(1):36-40.
2002: Tsuneyuki Ubagai; Masako Ochiai; Toshihiko Kawamori; Hiroshi Imai; Takashi Sugimura; Minako Nagao; Hitoshi Nakagama
Efficient induction of rat large intestinal tumors with a new spectrum of mutations by intermittent administration of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in combination with a high fat diet.
Carcinogenesis 2002;23(1):197-200.
2001: Daiya Takai; Yukiko Yagi; Kuniko Wakazono; Nobuya Ohishi; Y Morita; Takashi Sugimura; Toshikazu Ushijima
Silencing of HTR1B and reduced expression of EDN1 in human lung cancers, revealed by methylation-sensitive representational difference analysis.
Oncogene 2001;20(51):7505-13.
2001: Naoko Watanabe; Eriko Okochi; M Mochizuki; Takashi Sugimura; Toshikazu Ushijima
The presence of single nucleotide instability in human breast cancer cell lines.
Cancer research 2001;61(21):7739-42.
2001: H Fukuda; Takashi Sugimura; Minako Nagao; Hitoshi Nakagama
Detection and isolation of minisatellite Pc-1 binding proteins.
Biochimica et biophysica acta 2001;1528(2-3):152-8.
2001: Masako Ochiai; Tsuneyuki Ubagai; Toshihiko Kawamori; Hiroshi Imai; Takashi Sugimura; Hitoshi Nakagama
High susceptibility of Scid mice to colon carcinogenesis induced by azoxymethane indicates a possible caretaker role for DNA-dependent protein kinase.
Carcinogenesis 2001;22(9):1551-5.
2001: Takashi Kuramoto; Tomoko Nomoto; Takashi Sugimura; Toshikazu Ushijima
Linkage mapping of the rat interleukin 1 receptor antagonist gene on chromosome 3.
Experimental animals / Japanese Association for Laboratory Animal Science 2001;50(4):355-7.
2001: Minako Nagao; Masako Ochiai; E Okochi; T Ushijima; Takashi Sugimura
LacI transgenic animal study: relationships among DNA-adduct levels, mutant frequencies and cancer incidences.
Mutation research 2001;477(1-2):119-24.
2001: Mitsuko Masutani; Tadashige Nozaki; Masatoshi Watanabe; Takahiro Ochiya; Fumio Hasegawa; Hitoshi Nakagama; Hiroshi Suzuki; Takashi Sugimura
Involvement of poly(ADP-ribose) polymerase in trophoblastic cell differentiation during tumorigenesis.
Mutation research 2001;477(1-2):111-7.
2001: Takashi Kuramoto; Tomoko Nomoto; Takashi Sugimura; Toshikazu Ushijima
Cloning of the rat agouti gene and identification of the rat nonagouti mutation.
Mammalian genome : official journal of the International Mammalian Genome Society 2001;12(6):469-71.
2001: Naoko Watanabe; Eriko Okochi; Y Hirayama; Y Shimada; K Yanagihara; M C Yoshida; S Takahashi; M Mochizuki; Takashi Sugimura; M Nagao; Toshikazu Ushijima
Single nucleotide instability without microsatellite instability in rat mammary carcinomas.
Cancer research 2001;61(6):2632-40.
2001: Masahiro Tsutsumi; Mitsuko Masutani; Tadashige Nozaki; Osamu Kusuoka; Toshifumi Tsujiuchi; Hitoshi Nakagama; Hiroshi Suzuki; Yoichi Konishi; Takashi Sugimura
Increased susceptibility of poly(ADP-ribose) polymerase-1 knockout mice to nitrosamine carcinogenicity.
Carcinogenesis 2001;22(1):1-3.
2000: Satoshi Yamashita; Y Yoshida; A Kurahashi; Takashi Sugimura; Toshikazu Ushijima
Construction of a high-throughput rat genetic mapping system with 466 arbitrarily primed-representational difference analysis markers.
Mammalian genome : official journal of the International Mammalian Genome Society 2000;11(11):982-8.
2000: P Davis; M Hakama; S Hisamichi; Tadao Kakizoe; T Sano; Takashi Sugimura
Report of the Thirteenth International Symposium of the Foundation for Promotion of Cancer Research: cancer screening-past, present and future.
Japanese journal of clinical oncology 2000;30(7):322-31.
2000: Daiya Takai; Yukiko Yagi; N Habib; Takashi Sugimura; Toshikazu Ushijima
Hypomethylation of LINE1 retrotransposon in human hepatocellular carcinomas, but not in surrounding liver cirrhosis.
Japanese journal of clinical oncology 2000;30(7):306-9.
2000: Takashi Sugimura; Toshikazu Ushijima
Genetic and epigenetic alterations in carcinogenesis.
Mutation research 2000;462(2-3):235-46.
2000: Mitsuko Masutani; Tadashige Nozaki; K Nakamoto; Hitoshi Nakagama; Hiroshi Suzuki; Osamu Kusuoka; Masahiro Tsutsumi; Takashi Sugimura
The response of Parp knockout mice against DNA damaging agents.
Mutation research 2000;462(2-3):159-66.
2000: Takashi Sugimura
Nutrition and dietary carcinogens.
Carcinogenesis 2000;21(3):387-95.
2000: Toshikazu Ushijima; M Yamamoto; M Suzui; Takashi Kuramoto; Y Yoshida; Tomoko Nomoto; Masae Tatematsu; Takashi Sugimura; M Nagao
Chromosomal mapping of genes controlling development, histological grade, depth of invasion, and size of rat stomach carcinomas.
Cancer research 2000;60(4):1092-6.
2000: Takashi Sugimura; M Nagao; K Wakabayashi
How we should deal with unavoidable exposure of man to environmental mutagens: cooked food mutagen discovery, facts and lessons for cancer prevention.
Mutation research 2000;447(1):15-25.
1999: T Nozaki; M Masutani; M Watanabe; Takahiro Ochiya; Fumio Hasegawa; Hitoshi Nakagama; H Suzuki; Takashi Sugimura
Syncytiotrophoblastic giant cells in teratocarcinoma-like tumors derived from Parp-disrupted mouse embryonic stem cells.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(23):13345-50.
1999: Eriko Okochi; Naoko Watanabe; Y Shimada; S Takahashi; Kuniko Wakazono; T Shirai; Takashi Sugimura; M Nagao; Toshikazu Ushijima
Preferential induction of guanine deletion at 5'-GGGA-3' in rat mammary glands by 2-amino- 1-methyl-6-phenylimidazo[4,5-b]pyridine.
Carcinogenesis 1999;20(10):1933-8.
1999: Takashi Sugimura; T Matsushima
Recollection: Dr. Frederick J. de Serres and the environmental mutagenesis and carcinogenesis panel established under the auspices of the US-Japan Cooperative Medical Science Program.
Mutation research 1999;437(2):83-7.
1999: M Yoshimoto; Masahiro Tsutsumi; K Iki; Yasutaka Sasaki; Toshifumi Tsujiuchi; Takashi Sugimura; K Wakabayashi; Yoichi Konishi
Carcinogenicity of heterocyclic amines for the pancreatic duct epithelium in hamsters.
Cancer letters 1999;143(2):235-9.
1999: Hitoshi Nakagama; K Souda; Masako Ochiai; Y Ishiguro; Takashi Sugimura; Minako Nagao
Genetic analysis of the susceptibility in rats to aberrant crypt foci formation by 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine, PhIP.
Cancer letters 1999;143(2):205-9.
1999: T Shimokawa; M Masutani; Y Ishiguro; S Araki; Y Aoki; H Nakagama; Takashi Sugimura
Linkage mapping of the rat poly(ADP-ribose) glycohydrolase (Parg) gene to chromosome 16.
Experimental animals / Japanese Association for Laboratory Animal Science 1999;48(3):217-8.
1999: Yoshikazu Hirayama; Kuniko Wakazono; M Yamamoto; M Kitano; Masae Tatematsu; M Nagao; Takashi Sugimura; Toshikazu Ushijima
Rare mutations of p53, Ki-ras, and beta-catenin genes and absence of K-sam and c-erbB-2 amplification in N-methyl-N'-nitro-N-nitrosoguanidine-induced rat stomach cancers.
Molecular carcinogenesis 1999;25(1):42-7.
1999: M Masutani; H Suzuki; Nobuo Kamada; M Watanabe; Otoya Ueda; T Nozaki; Kou-ichi Jishage; T Watanabe; T Sugimoto; Hitoshi Nakagama; Takahiro Ochiya; Takashi Sugimura
Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):2301-4.
1999: M Suzui; Toshikazu Ushijima; R H Dashwood; N Yoshimi; Takashi Sugimura; H Mori; M Nagao
Frequent mutations of the rat beta-catenin gene in colon cancers induced by methylazoxymethanol acetate plus 1-hydroxyanthraquinone.
Molecular carcinogenesis 1999;24(3):232-7.
1999: Y Yoshida; Toshikazu Ushijima; S Yamashita; Kohzoh Imai; Takashi Sugimura; M Nagao
Development of the arbitrarily primed-representational difference analysis method and chromosomal mapping of isolated high throughput rat genetic markers.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(2):610-5.
1999: Yoshikazu Hirayama; Toshikazu Ushijima; Takashi Kuramoto; M Kitano; Takashi Sugimura; M Nagao
Linkage mapping of the rat Msh2 DNA mismatch repair gene on chromosome 6.
Experimental animals / Japanese Association for Laboratory Animal Science 1999;48(1):63-4.
1998: Toshikazu Ushijima; Tomoko Nomoto; Takashi Sugimura; D E Housman; M Nagao
Isolation of 48 genetic markers appropriate for high throughput genotyping of inbred rat strains by B1 repetitive sequence-representational difference analysis.
Mammalian genome : official journal of the International Mammalian Genome Society 1998;9(12):1008-12.
1998: S Yamada; H Shima; M Toyota; Toshikazu Ushijima; Takashi Kuramoto; T Serikawa; K Okada; K Sato; Takashi Sugimura; M Nagao; H Nakagama
Linkage mapping of the Bra, Brb and Brg genes for rat protein phosphatase 2A 55 kDa B-regulatory subunit isotypes.
Japanese journal of cancer research : Gann 1998;89(10):1014-9.
1998: M Toyota; Toshikazu Ushijima; M Suzui; Y Murakumo; Kohzoh Imai; Takashi Sugimura; M Matsuyama
Generation of polymorphic markers tightly linked to the thymus enlargement loci by phenotype-directed representational difference analysis.
Mammalian genome : official journal of the International Mammalian Genome Society 1998;9(9):735-9.
1998: M Nagao; M Ochiai; Toshikazu Ushijima; M Watanabe; Takashi Sugimura; H Nakagama
Genetic determinant and environmental carcinogens.
Mutation research 1998;402(1-2):85-91.
1998: Takashi Sugimura
Cancer prevention: past, present, future.
Mutation research 1998;402(1-2):7-14.
1998: M Nagao; H Fujita; M Ochiai; K Wakabayashi; T Sofuni; T Matsushima; Takashi Sugimura; Toshikazu Ushijima
No direct correlation between mutant frequencies and cancer incidence induced by MeIQ in various organs of Big Blue mice.
Mutation research 1998;400(1-2):251-7.
1998: M Nagao; Takashi Sugimura
Multiple steps in carcinogenesis, multiple carcinogenic factors, and multiple primary tumors: can we develop an appropriate response for cancer prevention?
Drug metabolism reviews 1998;30(2):405-19.
1998: R H Dashwood; M Suzui; H Nakagama; Takashi Sugimura; M Nagao
High frequency of beta-catenin (ctnnb1) mutations in the colon tumors induced by two heterocyclic amines in the F344 rat.
Cancer research 1998;58(6):1127-9.
1998: Takashi Sugimura; M Terada
Experimental chemical carcinogenesis in the stomach and colon.
Japanese journal of clinical oncology 1998;28(3):163-7.
1997: H Okonogi; GR Stuart; Eriko Okochi; Toshikazu Ushijima; Takashi Sugimura; Barry W Glickman; M Nagao
Effects of gender and species on spectra of mutation induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in the lacI transgene.
Mutation research 1997;395(2-3):93-9.
1997: M Watanabe; Toshikazu Ushijima; T Shiraishi; R Yatani; J Shimazaki; T Kotake; Takashi Sugimura; M Nagao
Genetic alterations of androgen receptor gene in Japanese human prostate cancer.
Japanese journal of clinical oncology 1997;27(6):389-93.
1997: M Suzui; Toshikazu Ushijima; N Yoshimi; H Nakagama; A Hara; Takashi Sugimura; M Nagao; H Mori
No involvement of APC gene mutations in ulcerative colitis-associated rat colon carcinogenesis induced by 1-hydroxyanthraquinone and methylazoxymethanol acetate.
Molecular carcinogenesis 1997;20(4):389-93.
1997: T Nozaki; M Masutani; T Noda; D Saito; T Sugiyama; T Takato; K Wakabayashi; Hitoshi Nakagama; Takashi Sugimura
Helicobacter pylori extracts exhibit nicotinamide adenine dinucleotide-derived adenylation but not mono(adenosine 5'-diphosphate-ribosyl)ation of DNA ligase.
Japanese journal of cancer research : Gann 1997;88(10):921-4.
1997: S Yamada; H Nakagama; M Toyota; Toshikazu Ushijima; K Sato; Takashi Sugimura; M Nagao
Linkage mapping of rat Rb1 gene on chromosome 15.
Mammalian genome : official journal of the International Mammalian Genome Society 1997;8(6):454-5.
1997: K Wakabayashi; Y Totsuka; K Fukutome; A Oguri; H Ushiyama; Takashi Sugimura
Human exposure to mutagenic/carcinogenic heterocyclic amines and comutagenic beta-carbolines.
Mutation research 1997;376(1-2):253-9.
1997: Takashi Sugimura
Overview of carcinogenic heterocyclic amines.
Mutation research 1997;376(1-2):211-9.
1997: H Okonogi; Toshikazu Ushijima; X B Zhang; John A Heddle; T Suzuki; T Sofuni; J S Felton; James Tucker; Takashi Sugimura; M Nagao
Agreement of mutational characteristics of heterocyclic amines in lacI of the Big Blue mouse with those in tumor related genes in rodents.
Carcinogenesis 1997;18(4):745-8.
1997: Takashi Sugimura
Food and cancer prevention.
Cancer letters 1997;114(1-2):3-5.
1997: Toshikazu Ushijima; Keiichirou Morimura; Y Hosoya; H Okonogi; Masae Tatematsu; Takashi Sugimura; M Nagao
Establishment of methylation-sensitive-representational difference analysis and isolation of hypo- and hypermethylated genomic fragments in mouse liver tumors.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(6):2284-9.
1997: S Yamada; H Nakagama; M Toyota; Toshikazu Ushijima; K Okada; K Sato; Takashi Sugimura; M Nagao
Cloning of rat Brca2 and linkage mapping to chromosome 12.
Mammalian genome : official journal of the International Mammalian Genome Society 1997;8(11):850-1.
1997: H Okonogi; Toshikazu Ushijima; H Shimizu; Takashi Sugimura; M Nagao
Induction of aberrant crypt foci in C57BL/6N mice by 2-amino-9H-pyrido[2,3-b]indole (A alphaC) and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx).
Cancer letters 1997;111(1-2):105-9.