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Sunao Sugita

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Sunao Sugita; Masayo Takahashi; Shintaro Horie; Ayano Imai; Tatsushi Kawaguchi; Yuko Kawazoe; Hiroshi Keino; Manabu Mochizuki
Role of IL-22- and TNF-α-Producing Th22 Cells in Uveitis Patients with Behcet's Disease.
Manabu Mochizuki; Sunao Sugita; Koju Kamoi
Immunological homeostasis of the eye.
Sunao Sugita; Yoshihiko Usui; Ayano Imai; Kikuo Isoda; Masataka Ito; Yoichiro Iwakura; Yuko Kawazoe; Manabu Mochizuki
Mature Dendritic Cell Suppression by IL-1 Receptor Antagonist on Retinal Pigment Epithelium Cells.

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2013: Sunao Sugita; Masayo Takahashi; Shintaro Horie; Ayano Imai; Tatsushi Kawaguchi; Yuko Kawazoe; Hiroshi Keino; Manabu Mochizuki
Role of IL-22- and TNF-α-Producing Th22 Cells in Uveitis Patients with Behcet's Disease.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(11):5799-808.
2013: Manabu Mochizuki; Sunao Sugita; Koju Kamoi
Immunological homeostasis of the eye.
Progress in retinal and eye research 2013;33():10-27.
2013: Sunao Sugita; Yoshihiko Usui; Ayano Imai; Kikuo Isoda; Masataka Ito; Yoichiro Iwakura; Yuko Kawazoe; Manabu Mochizuki
Mature Dendritic Cell Suppression by IL-1 Receptor Antagonist on Retinal Pigment Epithelium Cells.
Investigative ophthalmology & visual science 2013;54(5):3240-9.
2013: Yuko Kawazoe; Keiko Miura; Sunao Sugita; Yukiko Yamada; Ai Akino; Manabu Mochizuki
Psoriasis triggered by infliximab in a patient with Behçet's disease.
Japanese journal of ophthalmology 2013;57(1):95-7.
2012: Manabu Ogawa; Norio Shimizu; Sunao Sugita; Ken Watanabe; Manabu Mochizuki
Novel diagnosis of fungal endophthalmitis by broad-range real-time PCR detection of fungal 28S ribosomal DNA.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie 2012;250(12):1877-83.
2012: Manabu Ogawa; Norio Shimizu; Sunao Sugita; Ken Watanabe; Ichiro Nakagawa; Manabu Mochizuki
Broad-range real-time PCR assay for detection of bacterial DNA in ocular samples from infectious endophthalmitis.
Japanese journal of ophthalmology 2012;56(6):529-35.
2012: Sunao Sugita; Ken Watanabe; Koju Kamoi; Manabu Ogawa; Norio Shimizu; Manabu Mochizuki
Detection of Candida and Aspergillus species DNA using broad-range real-time PCR for fungal endophthalmitis.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie 2012;250(3):391-8.
2012: Sunao Sugita; Yukiko Yamada; Satoru Yamagami; Shintaro Horie; Ayano Imai; Yuko Kawazoe; Manabu Mochizuki
Inhibitory effect of corneal endothelial cells on IL-17-producing Th17 cells.
The British journal of ophthalmology 2012;96(2):293-9.
2012: Ayano Imai; Yuko Kawazoe; Hiroshi Keino; Kazuichi Maruyama; Sunao Sugita; Yukiko Yamada; Shintaro Horie; Manabu Mochizuki
Immunosuppressive properties of regulatory T cells generated by incubation of peripheral blood mononuclear cells with supernatants of human RPE cells.
Investigative ophthalmology & visual science 2012;53(11):7299-309.
2012: Sunao Sugita; Yukiko Yamada; Shintaro Horie; Ayano Imai; Yuko Kawazoe; Manabu Mochizuki
Inhibition of Th17 differentiation by anti-TNF-alpha therapy in uveitis patients with Behçet's disease.
Arthritis research & therapy 2012;14(3):R99.
2012: Yuko Kawazoe; Hiroshi Keino; Shintaro Horie; Ayano Imai; Sunao Sugita; Yukiko Yamada; Manabu Mochizuki
Retinoic acid from retinal pigment epithelium induces T regulatory cells.
Experimental eye research 2012;94(1):32-40.
2011: Miwa Higashi; Shoko Murayama; Kiyobumi Ota; Nobuo Sanjo; Sunao Sugita; Takanori Yokota; Hidehiro Mizusawa
[Case report; a case of chronic progressive neuro-Behcet's disease with extensive brain atrophy].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2011;100(12):3618-21.
2011: Sunao Sugita; Hiroshi Takase; Yukiko Yamada; Shintaro Horie; Yuko Kawazoe; Manabu Mochizuki
Suppression of interleukin-17-producing T-helper 17 cells by retinal pigment epithelial cells.
Japanese journal of ophthalmology 2011;55(5):565-75.
2011: Sunao Sugita; Shizu Inoue; Manabu Ogawa; Norio Shimizu; Manabu Mochizuki
Diagnosis of ocular toxoplasmosis by two polymerase chain reaction (PCR) examinations: qualitative multiplex and quantitative real-time.
Japanese journal of ophthalmology 2011;55(5):495-501.
2011: Sunao Sugita; Yukiko Yamada; Shintaro Horie; Orie Nakamura; Kazumi Ishidoh; Yoshimi Yamamoto; Satoru Yamagami; Manabu Mochizuki
Induction of T regulatory cells by cytotoxic T-lymphocyte antigen-2α on corneal endothelial cells.
Investigative ophthalmology & visual science 2011;52(5):2598-605.
2011: Sunao Sugita; Yukiko Yamada; Manabu Mochizuki
Relationship between serum infliximab levels and acute uveitis attacks in patients with Behcet disease.
The British journal of ophthalmology 2011;95(4):549-52.
2011: Sunao Sugita; Norio Shimizu; Ken Watanabe; Miki Katayama; Shintaro Horie; Manabu Ogawa; Hiroshi Takase; Yoshiharu Sugamoto; Manabu Mochizuki
Diagnosis of bacterial endophthalmitis by broad-range quantitative PCR.
The British journal of ophthalmology 2011;95(3):345-9.
2011: Yukiko Yamada; Sunao Sugita; Hiroyuki Tanaka; Koju Kamoi; Hiroshi Takase; Manabu Mochizuki
Timing of recurrent uveitis in patients with Behcet's disease receiving infliximab treatment.
The British journal of ophthalmology 2011;95(2):205-8.
2011: Sunao Sugita; Yukiko Yamada; Satoshi Kaneko; Shintaro Horie; Manabu Mochizuki
Induction of regulatory T cells by infliximab in Behcet's disease.
Investigative ophthalmology & visual science 2011;52(1):476-84.
2010: Tatsushi Kawaguchi; Sunao Sugita; Yukiko Yamada; Masaru Miyanaga; Manabu Mochizuki
Regression of optic disc neovascularization in patients with Behçet's uveoretinitis after infliximab therapy.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2010;26(6):627-30.
2010: Sunao Sugita; Shintaro Horie; Yukiko Yamada; Manabu Mochizuki
Inhibition of B-cell activation by retinal pigment epithelium.
Investigative ophthalmology & visual science 2010;51(11):5783-8.
2010: Yusuke Nakauchi; Hiroshi Takase; Sunao Sugita; Manabu Mochizuki; Satoko Shibata; Yasuyoshi Ishiwata; Yuka Shibuya; Masato Yasuhara; Osamu Miura; Ayako Arai
Concurrent administration of intravenous systemic and intravitreal methotrexate for intraocular lymphoma with central nervous system involvement.
International journal of hematology 2010;92(1):179-85.
2010: Shintaro Horie; Sunao Sugita; Yuri Futagami; Yukiko Yamada; Manabu Mochizuki
Human retinal pigment epithelium-induced CD4+CD25+ regulatory T cells suppress activation of intraocular effector T cells.
Clinical immunology (Orlando, Fla.) 2010;136(1):83-95.
2010: Yukiko Yamada; Sunao Sugita; Shintaro Horie; Satoru Yamagami; Manabu Mochizuki
Mechanisms of immune suppression for CD8+ T cells by human corneal endothelial cells via membrane-bound TGFbeta.
Investigative ophthalmology & visual science 2010;51(5):2548-57.
2010: Sunao Sugita; Shintaro Horie; Yukiko Yamada; Hiroshi Keino; Yoshihiko Usui; Masaru Takeuchi; Manabu Mochizuki
Suppression of bystander T helper 1 cells by iris pigment epithelium-inducing regulatory T cells via negative costimulatory signals.
Investigative ophthalmology & visual science 2010;51(5):2529-36.
2010: Masaru Miyanaga; Sunao Sugita; Norio Shimizu; Tomohiro Morio; Kazunori Miyata; Kazuichi Maruyama; Shigeru Kinoshita; Manabu Mochizuki
A significant association of viral loads with corneal endothelial cell damage in cytomegalovirus anterior uveitis.
The British journal of ophthalmology 2010;94(3):336-40.
2010: Yukiko Yamada; Sunao Sugita; Hiroyuki Tanaka; Koju Kamoi; Tatsushi Kawaguchi; Manabu Mochizuki
Comparison of infliximab versus ciclosporin during the initial 6-month treatment period in Behçet disease.
The British journal of ophthalmology 2010;94(3):284-8.
2010: Hiroyuki Tanaka; Sunao Sugita; Yukiko Yamada; Tatsushi Kawaguchi; Yoichi Iwanaga; Koju Kamoi; Mako Yokota; Hiroshi Takase; Manabu Mochizuki
[Effects and safety of infliximab administration in refractory uveoretinitis with Behçet's disease].
Nippon Ganka Gakkai zasshi 2010;114(2):87-95.
2009: Sunao Sugita; Shintaro Horie; Orie Nakamura; Kazuichi Maruyama; Hiroshi Takase; Yoshihiko Usui; Masaru Takeuchi; Kazumi Ishidoh; Masato Koike; Yasuo Uchiyama; Christoph Peters; Yoshimi Yamamoto; Manabu Mochizuki
Acquisition of T regulatory function in cathepsin L-inhibited T cells by eye-derived CTLA-2alpha during inflammatory conditions.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(8):5013-22.
2009: Sunao Sugita
Role of ocular pigment epithelial cells in immune privilege.
Archivum immunologiae et therapiae experimentalis 2009;57(4):263-8.
2009: Shintaro Horie; Sunao Sugita; Yuri Futagami; Tastushi Kawaguchi; Koju Kamoi; Shiroaki Shirato; Manabu Mochizuki
Human iris pigment epithelium suppresses activation of bystander T cells via TGFbeta-TGFbeta receptor interaction.
Experimental eye research 2009;88(6):1033-42.
2009: Sunao Sugita; Yoshihiko Usui; Shintaro Horie; Yuri Futagami; Hiroyuki Aburatani; Taku Okazaki; Tasuku Honjo; Masaru Takeuchi; Manabu Mochizuki
T-cell suppression by programmed cell death 1 ligand 1 on retinal pigment epithelium during inflammatory conditions.
Investigative ophthalmology & visual science 2009;50(6):2862-70.
2009: Sunao Sugita; Hiroshi Takase; Yoshiharu Sugamoto; Ayako Arai; Osamu Miura; Manabu Mochizuki
Diagnosis of intraocular lymphoma by polymerase chain reaction analysis and cytokine profiling of the vitreous fluid.
Japanese journal of ophthalmology 2009;53(3):209-14.
2009: Yuri Futagami; Sunao Sugita; Takuro Fujimaki; T Yokoyama; Tomohiro Morio; Manabu Mochizuki
Bilateral anterior granulomatous keratouveitis with sunset glow fundus in a patient with autoimmune polyglandular syndrome.
Ocular immunology and inflammation 2009;17(2):88-90.
2009: Sunao Sugita; Yoshihiko Usui; Shintaro Horie; Yuri Futagami; Yukiko Yamada; Juan Ma; Takeshi Kezuka; Hirofumi Hamada; Tomohiko Usui; Manabu Mochizuki; Satoru Yamagami
Human corneal endothelial cells expressing programmed death-ligand 1 (PD-L1) suppress PD-1+ T helper 1 cells by a contact-dependent mechanism.
Investigative ophthalmology & visual science 2009;50(1):263-72.
2008: Sunao Sugita; Shintaro Horie; Orie Nakamura; Yuri Futagami; Hiroshi Takase; Hiroshi Keino; Hiroyuki Aburatani; Nobuhiko Katunuma; Kazumi Ishidoh; Yoshimi Yamamoto; Manabu Mochizuki
Retinal pigment epithelium-derived CTLA-2alpha induces TGFbeta-producing T regulatory cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(11):7525-36.
2008: Sunao Sugita; N Shimizu; K Watanabe; M Mizukami; T Morio; Yoshiharu Sugamoto; Manabu Mochizuki
Use of multiplex PCR and real-time PCR to detect human herpes virus genome in ocular fluids of patients with uveitis.
The British journal of ophthalmology 2008;92(7):928-32.
2008: S Kido; Sunao Sugita; S Horie; M Miyanaga; K Miyata; N Shimizu; T Morio; Manabu Mochizuki
Association of varicella zoster virus load in the aqueous humor with clinical manifestations of anterior uveitis in herpes zoster ophthalmicus and zoster sine herpete.
The British journal of ophthalmology 2008;92(4):505-8.
2008: Hidemi Takahashi; Sunao Sugita; Norio Shimizu; Manabu Mochizuki
A high viral load of Epstein-Barr virus DNA in ocular fluids in an HLA-B27-negative acute anterior uveitis patient with psoriasis.
Japanese journal of ophthalmology 2008;52(2):136-8.
2008: Sunao Sugita; Youichi Iwanaga; Tatsushi Kawaguchi; Yuri Futagami; Shintaro Horie; Tomoka Usui; Sayaka Yamamoto; Yoshiharu Sugamoto; Manabu Mochizuki; Norio Shimizu; Ken Watanabe; Miki Mizukami; Tomohiro Morio
[Detection of herpesvirus genome by multiplex polymerase chain reaction (PCR) and real-time PCR in ocular fluids of patients with acute retinal necrosis].
Nippon Ganka Gakkai zasshi 2008;112(1):30-8.
2007: Sunao Sugita; Yuri Futagami; Shintaro Horie; Manabu Mochizuki
Transforming growth factor beta-producing Foxp3(+)CD8(+)CD25(+) T cells induced by iris pigment epithelial cells display regulatory phenotype and acquire regulatory functions.
Experimental eye research 2007;85(5):626-36.
2007: Sunao Sugita; Norio Shimizu; Tastushi Kawaguchi; Nobuaki Akao; Tomohiro Morio; Manabu Mochizuki
Identification of human herpesvirus 6 in a patient with severe unilateral panuveitis.
Archives of ophthalmology 2007;125(10):1426-7.
2007: Sunao Sugita; Hiroshi Takase; Chikako Taguchi; Manabu Mochizuki
The role of soluble TNF receptors for TNF-alpha in uveitis.
Investigative ophthalmology & visual science 2007;48(7):3246-52.
2007: Yuri Futagami; Sunao Sugita; Jose Vega; Kazuhiro Ishida; Hiroshi Takase; Kazuichi Maruyama; Hiroyuki Aburatani; Manabu Mochizuki
Role of thrombospondin-1 in T cell response to ocular pigment epithelial cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(11):6994-7005.
2007: Sunao Sugita; Hiroshi Takase; Tatsushi Kawaguchi; Chikako Taguchi; Manabu Mochizuki
Cross-reaction between tyrosinase peptides and cytomegalovirus antigen by T cells from patients with Vogt-Koyanagi-Harada disease.
International ophthalmology 2007;27(2-3):87-95.
2007: Parisa Zamiri; Sunao Sugita; J Wayne Streilein
Immunosuppressive properties of the pigmented epithelial cells and the subretinal space.
Chemical immunology and allergy 2007;92():86-93.
2006: Sunao Sugita; Hiroshi Keino; Yuri Futagami; Hiroshi Takase; Manabu Mochizuki; Joan Stein-Streilein; J Wayne Streilein
B7+ iris pigment epithelial cells convert T cells into CTLA-4+, B7-expressing CD8+ regulatory T cells.
Investigative ophthalmology & visual science 2006;47(12):5376-84.
2006: Sunao Sugita; Hiroshi Takase; Takeshi Yoshida; Yoshiharu Sugamoto; T Watanabe; Manabu Mochizuki
Intraocular soluble IL-2 receptor alpha in a patient with adult T cell leukaemia with intraocular invasion.
The British journal of ophthalmology 2006;90(9):1204-6.
2006: Sunao Sugita; Hiroshi Takase; Chikako Taguchi; Yasuhisa Imai; Koju Kamoi; Tatsushi Kawaguchi; Yoshiharu Sugamoto; Yuri Futagami; Kyogo Itoh; Manabu Mochizuki
Ocular infiltrating CD4+ T cells from patients with Vogt-Koyanagi-Harada disease recognize human melanocyte antigens.
Investigative ophthalmology & visual science 2006;47(6):2547-54.
2006: Hiroshi Takase; Sunao Sugita; Chikako Taguchi; Yasuhisa Imai; Manabu Mochizuki
Capacity of ocular infiltrating T helper type 1 cells of patients with non-infectious uveitis to produce chemokines.
The British journal of ophthalmology 2006;90(6):765-8.
2006: Hiroshi Takase; Yuri Futagami; Tomoko Yoshida; Koju Kamoi; Sunao Sugita; Yasuhisa Imai; Manabu Mochizuki
Cytokine profile in aqueous humor and sera of patients with infectious or noninfectious uveitis.
Investigative ophthalmology & visual science 2006;47(4):1557-61.
2006: Tatsushi Kawaguchi; Mako Yokota; Sunao Sugita; Manabu Mochizuki
[Disc neovascularization in a patient with Vogt-Koyanagi-Harada disease and efficacy of steroid pulse therapy].
Nippon Ganka Gakkai zasshi 2006;110(1):58-60.
2006: Sunao Sugita; Tat Fong Ng; Philip J Lucas; Ronald E Gress; J Wayne Streilein
B7+ iris pigment epithelium induce CD8+ T regulatory cells; both suppress CTLA-4+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(1):118-27.
2004: Shigeaki Ohno; Satoshi Nakamura; Sadao Hori; Machiko Shimakawa; Hidetoshi Kawashima; Manabu Mochizuki; Sunao Sugita; Satoki Ueno; Kazuyuki Yoshizaki; Goro Inaba
Efficacy, safety, and pharmacokinetics of multiple administration of infliximab in Behçet's disease with refractory uveoretinitis.
The Journal of rheumatology 2004;31(7):1362-8.
2004: Sunao Sugita; Tat Fong Ng; Johannes Schwartzkopff; J Wayne Streilein
CTLA-4+CD8+ T cells that encounter B7-2+ iris pigment epithelial cells express their own B7-2 to achieve global suppression of T cell activation.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(7):4184-94.
2003: Sunao Sugita; J Wayne Streilein
Iris pigment epithelium expressing CD86 (B7-2) directly suppresses T cell activation in vitro via binding to cytotoxic T lymphocyte-associated antigen 4.
The Journal of experimental medicine 2003;198(1):161-71.
2003: Mako Yokota; Hiroshi Takase; Yasuhisa Imai; Kojyu Kamoi; Sunao Sugita; Hiroyuki Morita; Toichiro Takizawa; Sumiyoshi Tanaka; De Fen Shen; Chi-Chao Chan; Manabu Mochizuki
[A case of intraocular malignant lymphoma diagnosed by immunoglobulin gene rearrangement and translocation, and IL-10/IL-6 ratio in the vitreous fluid].
Nippon Ganka Gakkai zasshi 2003;107(5):287-91.
2002: Hiroshi Takase; Sunao Sugita; Douglas J Rhee; Yasuhisa Imai; Chikako Taguchi; Yoshiharu Sugamoto; Yoshitsugu Tagawa; Jun Nishihira; Paul Russell; Manabu Mochizuki
The presence of macrophage migration inhibitory factor in human trabecular meshwork and its upregulatory effects on the T helper 1 cytokine.
Investigative ophthalmology & visual science 2002;43(8):2691-6.