Hiroshi Sugiyama

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Endo Masayuki; Hidaka Kumi; Kato Takayuki; Namba Keiichi; Sugiyama Hiroshi
DNA prism structures constructed by folding of multiple rectangular arms.
Endo Masayuki; Sugiyama Hiroshi
Chemical approaches to DNA nanotechnology.
Morinaga Hironobu; Yonekura Shin-Ichiro; Nakamura Nobuya; Sugiyama Hiroshi; Yonei Shuji; Zhang-Akiyama Qiu-Mei
Purification and characterization of Caenorhabditis elegans NTH, a homolog of human endonuclease III: essential role of N-terminal region.

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All Publications

2009: Endo Masayuki; Hidaka Kumi; Kato Takayuki; Namba Keiichi; Sugiyama Hiroshi
DNA prism structures constructed by folding of multiple rectangular arms.
Journal of the American Chemical Society 2009;131(43):15570-1.
2009: Endo Masayuki; Sugiyama Hiroshi
Chemical approaches to DNA nanotechnology.
Chembiochem : a European journal of chemical biology 2009;10(15):2420-43.
2009: Morinaga Hironobu; Yonekura Shin-Ichiro; Nakamura Nobuya; Sugiyama Hiroshi; Yonei Shuji; Zhang-Akiyama Qiu-Mei
Purification and characterization of Caenorhabditis elegans NTH, a homolog of human endonuclease III: essential role of N-terminal region.
DNA repair 2009;8(7):844-51.
2009: Yanagie H; Kumada H; Sakurai Y; Nakamura T; Furuya Y; Sugiyama H; Ono K; Takamoto S; Eriguchi M; Takahashi H
Dosimetric evaluation of neutron capture therapy for local advanced breast cancer.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 2009;67(7-8 Suppl):S63-6.
2009: Suzuki Tsukasa; Asami Yukihiro; Takahashi Teruyuki; Wang Xiaofei; Watanabe Takayoshi; Bando Toshikazu; Sugiyama Hiroshi; Fukuda Noboru; Nagase Hiroki
Development of a molecule-recognized promoter DNA sequence for inhibition of HER2 expression.
The Journal of antibiotics 2009;62(6):339-41.
2009: Nagashima Takashi; Aoyama Takahiko; Yokoe Tsubasa; Fukasawa Akiko; Fukuda Noboru; Ueno Takahiro; Sugiyama Hiroshi; Nagase Hiroki; Matsumoto Yoshiaki
Pharmacokinetic modeling and prediction of plasma pyrrole-imidazole polyamide concentration in rats using simultaneous urinary and biliary excretion data.
Biological & pharmaceutical bulletin 2009;32(5):921-7.
2009: Zhang-Akiyama Qiu-Mei; Morinaga Hironobu; Kikuchi Masahiro; Yonekura Shin-Ichiro; Sugiyama Hiroshi; Yamamoto Kazuo; Yonei Shuji
KsgA, a 16S rRNA adenine methyltransferase, has a novel DNA glycosylase/AP lyase activity to prevent mutations in Escherichia coli.
Nucleic acids research 2009;37(7):2116-25.
2009: Ueno Takahiro; Fukuda Noboru; Tsunemi Akiko; Yao En-Hui; Matsuda Hiroyuki; Tahira Kazunobu; Matsumoto Taro; Matsumoto Koichi; Matsumoto Yoshiaki; Nagase Hiroki; Sugiyama Hiroshi; Sawamura Tatsuya
A novel gene silencer, pyrrole-imidazole polyamide targeting human lectin-like oxidized low-density lipoprotein receptor-1 gene improves endothelial cell function.
Journal of hypertension 2009;27(3):508-16.
2009: Sannohe Yuta; Sato Kyosuke; Matsugami Akimasa; Shinohara Ken-ichi; Mashimo Tomoko; Katahira Masato; Sugiyama Hiroshi
The orientation of the ends of G-quadruplex structures investigated using end-extended oligonucleotides.
Bioorganic & medicinal chemistry 2009;17(5):1870-5.
2009: Yao En-Hui; Fukuda Noboru; Ueno Takahiro; Matsuda Hiroyuki; Nagase Hiroki; Matsumoto Yoshiaki; Sugiyama Hiroshi; Matsumoto Koichi
A pyrrole-imidazole polyamide targeting transforming growth factor-beta1 inhibits restenosis and preserves endothelialization in the injured artery.
Cardiovascular research 2009;81(4):797-804.
2009: Kashiwazaki Gengo; Bando Toshikazu; Shinohara Ken-ichi; Minoshima Masafumi; Nishijima Shigeki; Sugiyama Hiroshi
Cooperative alkylation of double-strand human telomere repeat sequences by PI polyamides with 11-base-pair recognition based on a heterotrimeric design.
Bioorganic & medicinal chemistry 2009;17(3):1393-7.
2009: Endo Masayuki; Sugiyama Hiroshi
Three-dimensional DNA nanostructures constructed by folding of multiple rectangles.
Nucleic acids symposium series (2004) 2009;(53):81-2.
2009: Minoshima Masafumi; Bando Toshikazu; Shinohara Ken-ichi; Sugiyama Hiroshi
Molecular design of sequence specific DNA alkylating agents.
Nucleic acids symposium series (2004) 2009;(53):69-70.
2008: Xu Yan; Sato Hiroyuki; Sannohe Yuta; Shinohara Ken-ichi; Sugiyama Hiroshi
Stable lariat formation based on a G-quadruplex scaffold.
Journal of the American Chemical Society 2008;130(49):16470-1.
2008: Fujimoto Jun; Bando Toshikazu; Minoshima Masafumi; Kashiwazaki Gengo; Nishijima Shigeki; Shinohara Ken-ichi; Sugiyama Hiroshi
Perylene-conjugated pyrrole polyamide as a sequence-specific fluorescent probe.
Bioorganic & medicinal chemistry 2008;16(22):9741-4.
2008: Takahashi Teruyuki; Asami Yukihiro; Kitamura Eiko; Suzuki Tsukasa; Wang Xiaofei; Igarashi Jun; Morohashi Aiko; Shinojima Yui; Kanou Hisao; Saito Kosuke; Takasu Toshiaki; Nagase Hiroki; Harada Yuichi; Kuroda Kazumichi; Watanabe Takayoshi; Kumamoto Satoshi; Aoyama Takahiko; Matsumoto Yoshiaki; Bando Toshikazu; Sugiyama Hiroshi; Yoshida-Noro Chikako; Fukuda Noboru; Hayashi Nariyuki
Development of pyrrole-imidazole polyamide for specific regulation of human aurora kinase-A and -B gene expression.
Chemistry & biology 2008;15(8):829-41.
2008: Okamoto Kenji; Sannohe Yuta; Mashimo Tomoko; Sugiyama Hiroshi; Terazima Masahide
G-quadruplex structures of human telomere DNA examined by single molecule FRET and BrG-substitution.
Bioorganic & medicinal chemistry 2008;16(14):6873-9.
2008: Yao En-Hui; Fukuda Noboru; Ueno Takahiro; Matsuda Hiroyuki; Matsumoto Koichi; Nagase Hiroki; Matsumoto Yoshiaki; Takasaka Ayako; Serie Kazuo; Sugiyama Hiroshi; Sawamura Tatsuya
Novel gene silencer pyrrole-imidazole polyamide targeting lectin-like oxidized low-density lipoprotein receptor-1 attenuates restenosis of the artery after injury.
Hypertension 2008;52(1):86-92.
2008: Fujimoto Jun; Bando Toshikazu; Minoshima Masafumi; Uchida Shinsuke; Iwasaki Makoto; Shinohara Ken-ichi; Sugiyama Hiroshi
Detection of triplet repeat sequences in the double-stranded DNA using pyrene-functionalized pyrrole-imidazole polyamides with rigid linkers.
Bioorganic & medicinal chemistry 2008;16(11):5899-907.
2008: Minoshima Masafumi; Bando Toshikazu; Sasaki Shunta; Fujimoto Jun; Sugiyama Hiroshi
Pyrrole-imidazole hairpin polyamides with high affinity at 5'-CGCG-3' DNA sequence; influence of cytosine methylation on binding.
Nucleic acids research 2008;36(9):2889-94.
2008: Bando Toshikazu; Minoshima Masafumi; Kashiwazaki Gengo; Shinohara Ken-Ichi; Sasaki Shunta; Fujimoto Jun; Ohtsuki Akimichi; Murakami Masataka; Nakazono Satomi; Sugiyama Hiroshi
Requirement of beta-alanine components in sequence-specific DNA alkylation by pyrrole-imidazole conjugates with seven-base pair recognition.
Bioorganic & medicinal chemistry 2008;16(5):2286-91.
2008: Mashimo Tomoko; Sannohe Yuta; Yagi Hirotaka; Sugiyama Hiroshi
Folding pathways of hybrid-1 and hybrid-2 G-quadruplex structures.
Nucleic acids symposium series (2004) 2008;(52):409-10.
2008: Kashiwazaki Gengo; Bando Toshikazu; Sugiyama Hiroshi
Sequence-specific alkylation of DNA by pyrrole-imidazole polyamides through cooperative interaction.
Nucleic acids symposium series (2004) 2008;(52):365-6.
2008: Minoshima Masafumi; Chou James; Lefebvre Sophie; Bando Toshikazu; Shinohara Ken-ichi; Gottesfeld Joel M; Sugiyama Hiroshi
Targeting specific gene by alkylating pyrrole-imidazole polyamides.
Nucleic acids symposium series (2004) 2008;(52):363-4.
2008: Sannohe Yuta; Sato Kyosuke; Matsugami Akimasa; Shinohara Kenichi; Mashimo Tomoko; Katahira Masato; Sugiyama Hiroshi
Orientation of ends of G-quadruplex structure investigated with end-extended oligonucleotides.
Nucleic acids symposium series (2004) 2008;(52):171-2.
2008: Yagi Hirotaka; Mashimo Tomoko; Sannohe Yuta; Sugiyama Hiroshi
Structural stability analysis of the intermediates in the folding pathway of human telomeric hybrid-1 G-quadruplex based on fragment molecular orbital method.
Nucleic acids symposium series (2004) 2008;(52):161-2.
2008: Sasaki Shunta; Bando Toshikazu; Minoshima Masafumi; Shinohara Ken-ichi; Sugiyama Hiroshi
Sequence-specific alkylation by Y-shaped and tandem hairpin pyrrole-imidazole polyamides.
Chemistry (Weinheim an der Bergstrasse, Germany) 2008;14(3):864-70.
2007: Bando Toshikazu; Fujimoto Jun; Minoshima Masafumi; Shinohara Ken-Ichi; Sasaki Shunta; Kashiwazaki Gengo; Mizumura Masatoshi; Sugiyama Hiroshi
Detection of CAG repeat DNA sequences by pyrene-functionalized pyrrole-imidazole polyamides.
Bioorganic & medicinal chemistry 2007;15(22):6937-42.
2007: Yonekura Shin-Ichiro; Nakamura Nobuya; Doi Takashi; Sugiyama Hiroshi; Yamamoto Kazuo; Yonei Shuji; Zhang Qiu-Mei
Recombinant Schizosaccharomyces pombe Nth1 protein exhibits DNA glycosylase activities for 8-oxo-7,8-dihydroguanine and thymine residues oxidized in the methyl group.
Journal of radiation research 2007;48(5):417-24.
2007: Watanabe Takayoshi; Tashiro Ryu; Sugiyama Hiroshi
Photoreaction at 5'-(G/C)AA(Br)UT-3' sequence in duplex DNA: efficient generation of uracil-5-yl radical by charge transfer.
Journal of the American Chemical Society 2007;129(26):8163-8.
2007: Minoshima Masafumi; Bando Toshikazu; Sasaki Shunta; Shinohara Ken-ichi; Shimizu Tatsuhiko; Fujimoto Jun; Sugiyama Hiroshi
DNA alkylation by pyrrole-imidazole seco-CBI conjugates with an indole linker: sequence-specific DNA alkylation with 10-base-pair recognition through heterodimer formation.
Journal of the American Chemical Society 2007;129(17):5384-90.
2007: Xu Yan; Hirao Yuuka; Nishimura Yoshifumi; Sugiyama Hiroshi
I-motif and quadruplex-based device that can control a protein release or bind and release small molecule to influence biological processes.
Bioorganic & medicinal chemistry 2007;15(3):1275-9.
2007: Sasaki Shunta; Minoshima Masafumi; Fujimoto Jun; Shinohara Ken-Ichi; Bando Toshikazu; Sugiyama Hiroshi
Sequence-specific alkylation by a tandem motif of pyrrole-imidazole CBI conjugate.
Nucleic acids symposium series (2004) 2007;(51):265-6.
2007: Xu Yan; Sato Hiroyuki; Shinohara Ken-Ichi; Komiyama Makoto; Sugiyama Hiroshi
T-loop formation by human telomeric G-quadruplex.
Nucleic acids symposium series (2004) 2007;(51):243-4.
2007: Mashimo Tomoko; Sugiyama Hiroshi
Folding pathways of human telomeric hybrid G-quadruplex structure.
Nucleic acids symposium series (2004) 2007;(51):239-40.
2007: Sugiyama Hiroshi
Chemical biology that controls DNA structure and function.
Nucleic acids symposium series (2004) 2007;(51):59-60.
2007: Minoshima Masafumi; Sasaki Shunta; Fujimoto Jun; Shinohara Ken-Ichi; Bando Toshikazu; Sugiyama Hiroshi
Synthesis and biological properties of pyrrole-imidazole polyamide conjugates.
Nucleic acids symposium series (2004) 2007;(51):35-6.
2007: Xu Yan; Tashiro Ryu; Sugiyama Hiroshi
Photochemical determination of different DNA structures.
Nature protocols 2007;2(1):78-87.
2007: Hirota Mikako; Fujiwara Tsuyoshi; Mineshita Satoru; Sugiyama Hiroshi; Teraoka Hirobumi
Distamycin A enhances the cytotoxicity of duocarmycin A and suppresses duocarmycin A-induced apoptosis in human lung carcinoma cells.
The international journal of biochemistry & cell biology 2007;39(5):988-96.
2006: Bando Toshikazu; Sugiyama Hiroshi
Synthesis and biological properties of sequence-specific DNA-alkylating pyrrole-imidazole polyamides.
Accounts of chemical research 2006;39(12):935-44.
2006: Zhang Wen; Minoshima Masafumi; Sugiyama Hiroshi
Base pair recognition of the stereochemically alpha-substituted gamma-turn of pyrrole/imidazole hairpin polyamides.
Journal of the American Chemical Society 2006;128(46):14905-12.
2006: Tashiro Ryu; Wang Andrew H-J; Sugiyama Hiroshi
Photoreactivation of DNA by an archaeal nucleoprotein Sso7d.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(45):16655-9.
2006: Sasaki Shunta; Bando Toshikazu; Minoshima Masafumi; Shimizu Tatsuhiko; Shinohara Ken-ichi; Takaoka Toshiyasu; Sugiyama Hiroshi
Sequence-specific alkylation of double-strand human telomere repeat sequence by pyrrole-imidazole polyamides with indole linkers.
Journal of the American Chemical Society 2006;128(37):12162-8.
2006: Xu Yan; Noguchi Yuki; Sugiyama Hiroshi
The new models of the human telomere d[AGGG(TTAGGG)3] in K+ solution.
Bioorganic & medicinal chemistry 2006;14(16):5584-91.
2006: Zhang Wen; Bando Toshikazu; Sugiyama Hiroshi
Discrimination of hairpin polyamides with an alpha-substituted-gamma-aminobutyric acid as a 5'-TG-3' reader in DNA minor groove.
Journal of the American Chemical Society 2006;128(27):8766-76.
2006: Bando Toshikazu; Sasaki Shunta; Minoshima Masafumi; Dohno Chikara; Shinohara Ken-ichi; Narita Akihiko; Sugiyama Hiroshi
Efficient DNA alkylation by a pyrrole-imidazole CBI conjugate with an indole linker: sequence-specific alkylation with nine-base-pair recognition.
Bioconjugate chemistry 2006;17(3):715-20.
2006: Shinohara Ken-ichi; Bando Toshikazu; Sasaki Shunta; Sakakibara Yogo; Minoshima Masafumi; Sugiyama Hiroshi
Antitumor activity of sequence-specific alkylating agents: pyrolle-imidazole CBI conjugates with indole linker.
Cancer science 2006;97(3):219-25.
2006: Xu Yan; Sugiyama Hiroshi
Photochemical approach to probing different DNA structures.
Angewandte Chemie (International ed. in English) 2006;45(9):1354-62.
2006: Matsuda Hiroyuki; Fukuda Noboru; Ueno Takahiro; Tahira Yoshiko; Ayame Hirohito; Zhang Wen; Bando Toshikazu; Sugiyama Hiroshi; Saito Satoshi; Matsumoto Koichi; Mugishima Hideo; Serie Kazuo
Development of gene silencing pyrrole-imidazole polyamide targeting the TGF-beta1 promoter for treatment of progressive renal diseases.
Journal of the American Society of Nephrology : JASN 2006;17(2):422-32.
2006: Yanagie H; Maruyama K; Takizawa T; Ishida O; Ogura K; Matsumoto T; Sakurai Y; Kobayashi T; Shinohara A; Rant J; Skvarc J; Ilic R; Kuhne G; Chiba M; Furuya Y; Sugiyama H; Hisa T; Ono K; Kobayashi H; Eriguchi M
Application of boron-entrapped stealth liposomes to inhibition of growth of tumour cells in the in vivo boron neutron-capture therapy model.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2006;60(1):43-50.
2006: Xu Yan; Yamazaki Shinya; Osuga Hideji; Sugiyama Hiroshi
The recognition of higher-order G-quadruplex by chiral cyclic-helicene molecules.
Nucleic acids symposium series (2004) 2006;(50):183-4.
2006: Minoshima Masafumi; Sasaki Shunta; Shinohara Ken-ichi; Shimizu Tatsuhiko; Bando Toshikazu; Sugiyama Hiroshi
Molecular design of DNA alkylating pyrrole-imidazole polyamides with longer recognition sequence.
Nucleic acids symposium series (2004) 2006;(50):165-6.
2006: Shimizu Tatsuhiko; Sasaki Shunta; Minoshima Masafumi; Shinohara Ken-ichi; Bando Toshikazu; Sugiyama Hiroshi
Synthesis and evaluation of sequence-specific DNA alkylating agents: effect of alkylation subunits.
Nucleic acids symposium series (2004) 2006;(50):155-6.
2006: Tashiro Ryu; Wang Andrew H-J; Sugiyama Hiroshi
Detection of photoinduced electron transfer from Sso7d to DNA.
Nucleic acids symposium series (2004) 2006;(50):149-50.
2006: Sasaki Shunta; Minoshima Masafumi; Shimizu Tatsuhiko; Fujimoto Jun; Shinohara Ken-ichi; Bando Toshikazu; Sugiyama Hiroshi
The biological impact of sequence-specific DNA alkylation by pyrrole-imidazole polyamides.
Nucleic acids symposium series (2004) 2006;(50):111-2.
2006: Kageyama Yukio; Sugiyama Hiroshi; Ayame Hirohito; Iwai Aki; Fujii Yasuhisa; Huang L Eric; Kizaka-Kondoh Shinae; Hiraoka Masahiro; Kihara Kazunori
Suppression of VEGF transcription in renal cell carcinoma cells by pyrrole-imidazole hairpin polyamides targeting the hypoxia responsive element.
Acta oncologica (Stockholm, Sweden) 2006;45(3):317-24.
2006: Shinohara Ken-ichi; Sasaki Shunta; Minoshima Masafumi; Bando Toshikazu; Sugiyama Hiroshi
Alkylation of template strand of coding region causes effective gene silencing.
Nucleic acids research 2006;34(4):1189-95.
2006: Xu Yan; Sugiyama Hiroshi
Formation of the G-quadruplex and i-motif structures in retinoblastoma susceptibility genes (Rb).
Nucleic acids research 2006;34(3):949-54.
2005: Lai Yu-Mu; Fukuda Noboru; Ueno Takahiro; Matsuda Hiroyuki; Saito Satoshi; Matsumoto Koichi; Ayame Hirohito; Bando Toshikazu; Sugiyama Hiroshi; Mugishima Hideo; Serie Kazuo
Synthetic pyrrole-imidazole polyamide inhibits expression of the human transforming growth factor-beta1 gene.
The Journal of pharmacology and experimental therapeutics 2005;315(2):571-5.
2005: Bando Toshikazu; Narita Akihiko; Sasaki Shunta; Sugiyama Hiroshi
Specific adenine alkylation by pyrrole-imidazole CBI conjugates.
Journal of the American Chemical Society 2005;127(40):13890-5.
2005: Tashiro Ryu; Sugiyama Hiroshi
Biomolecule-based switching devices that respond inversely to thermal stimuli.
Journal of the American Chemical Society 2005;127(7):2094-7.
2005: Zhang Qiu-Mei; Yonekura Shin-Ichiro; Takao Masashi; Yasui Akira; Sugiyama Hiroshi; Yonei Shuji
DNA glycosylase activities for thymine residues oxidized in the methyl group are functions of the hNEIL1 and hNTH1 enzymes in human cells.
DNA repair 2005;4(1):71-9.
2005: Hasiba Waka; Xu Yan; Sugiyama Hiroshi
Reactivity of 2'-deoxyuridin-1'-yl radical in various DNA structures.
Nucleic acids symposium series (2004) 2005;(49):179-80.
2005: Xu Yan; Sugiyama Hiroshi
Structural and functional characterizations of the G-quartet and i-motif elements in retinoblastoma susceptibility genes (Rb).
Nucleic acids symposium series (2004) 2005;(49):177-8.
2005: Shinohara Ken-ichi; Sasaki Shunta; Bando Toshikazu; Sugiyama Hiroshi
Sequence-specific gene silencing by alkylating Py-Im polyamide.
Nucleic acids symposium series (2004) 2005;(49):75-6.
2004: Inase Aki; Kodama Takashi S; Sharif Jafar; Xu Yan; Ayame Hirohito; Sugiyama Hiroshi; Iwai Shigenori
Binding of distamycin A to UV-damaged DNA.
Journal of the American Chemical Society 2004;126(35):11017-23.
2004: Bando Toshikazu; Narita Akihiko; Asada Ken; Ayame Hirohito; Sugiyama Hiroshi
Enantioselective DNA alkylation by a pyrrole-imidazole S-CBI conjugate.
Journal of the American Chemical Society 2004;126(29):8948-55.
2004: Xu Yan; Zhang You Xin; Sugiyama Hiroshi; Umano Tomoko; Osuga Hideji; Tanaka Kazuhiko
(P)-helicene displays chiral selection in binding to Z-DNA.
Journal of the American Chemical Society 2004;126(21):6566-7.
2004: Xu Yan; Sugiyama Hiroshi
Highly efficient photochemical 2'-deoxyribonolactone formation at the diagonal loop of a 5-iodouracil-containing antiparallel G-quartet.
Journal of the American Chemical Society 2004;126(20):6274-9.
2004: Shinohara Ken-Ichi; Narita Akihiko; Oyoshi Takanori; Bando Toshikazu; Teraoka Hirobumi; Sugiyama Hiroshi
Sequence-specific gene silencing in mammalian cells by alkylating pyrrole-imidazole polyamides.
Journal of the American Chemical Society 2004;126(16):5113-8.
2004: Murty Musti Sree Rama Chandra; Sugiyama Hiroshi
Biology of N-methylpyrrole-N-methylimidazole hairpin polyamide.
Biological & pharmaceutical bulletin 2004;27(4):468-74.
2004: Inase Aki; Kodama Takashi S; Sharif Jafar; Xu Yan; Ayame Hirohito; Sugiyama Hiroshi; Iwai Shigenori
Analysis of distamycin A binding to UV-damaged DNA.
Nucleic acids symposium series (2004) 2004;(48):257-8.
2004: Tashiro Ryu; Sugiyama Hiroshi
The molecular-thermometer based on B-Z transition of DNA.
Nucleic acids symposium series (2004) 2004;(48):89-90.
2004: Xu Yan; Sugiyama Hiroshi; Tanaka Kazuhiko; Osuga Hideji
The recognition of Z-DNA by chiral helicene.
Nucleic acids symposium series (2004) 2004;(48):87-8.
2003: Tashiro Ryu; Sugiyama Hiroshi
A nanothermometer based on the different pi stackings of B- and Z-DNA.
Angewandte Chemie (International ed. in English) 2003;42(48):6018-20.
2003: Tashiro Ryu; Sugiyama Hiroshi
Unique charge transfer properties of the four-base pi-stacks in Z-DNA.
Journal of the American Chemical Society 2003;125(50):15282-3.
2003: Xu Yan; Ikeda Reiko; Sugiyama Hiroshi
8-Methylguanosine: a powerful Z-DNA stabilizer.
Journal of the American Chemical Society 2003;125(44):13519-24.
2003: Takahashi Ryoko; Bando Toshikazu; Sugiyama Hiroshi
Specific alkylation of human telomere repeats by hairpin pyrrole-imidazole polyamide.
Bioorganic & medicinal chemistry 2003;11(12):2503-9.
2003: Zhang Q M; Hashiguchi K; Kino K; Sugiyama H; Yonei S
Ntg1 and Ntg2 proteins as 5-formyluracil-DNA glycosylases/AP lyases in Saccharomyces cerevisiae.
International journal of radiation biology 2003;79(5):341-9.
2003: Oyoshi Takanori; Kawakami Wakana; Narita Akihiko; Bando Toshikazu; Sugiyama Hiroshi
Inhibition of transcription at a coding sequence by alkylating polyamide.
Journal of the American Chemical Society 2003;125(16):4752-4.
2003: Bando Toshikazu; Narita Akihiko; Saito Isao; Sugiyama Hiroshi
Highly efficient sequence-specific DNA interstrand cross-linking by pyrrole/imidazole CPI conjugates.
Journal of the American Chemical Society 2003;125(12):3471-85.
2003: Hori Masaki; Yonei Shuji; Sugiyama Hiroshi; Kino Katsuhito; Yamamoto Kazuo; Zhang Qiu-Mei
Identification of high excision capacity for 5-hydroxymethyluracil mispaired with guanine in DNA of Escherichia coli MutM, Nei and Nth DNA glycosylases.
Nucleic acids research 2003;31(4):1191-6.
2003: Oyoshi Takanori; Kawai Kiyohiko; Sugiyama Hiroshi
Efficient C2'alpha-hydroxylation of deoxyribose in protein-induced Z-form DNA.
Journal of the American Chemical Society 2003;125(6):1526-31.
2003: Iiyama Takamasa; Chikira Makoto; Oyoshi Takanori; Sugiyama Hiroshi
Deglyco-peplomycin metal complexes on DNA fibers: a role of the sugar moiety for the stability and the orientation of the complexes.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2003;8(1-2):135-40.
2003: Iwai Shigenori; Inase Aki; Jafar Sharif; Higurashi Miho; Ohtsuki Takashi; Xu Yan; Sugiyama Hiroshi
Towards artificial repair of UV-damaged DNA: studies on drug binding and alkali hydrolysis.
Nucleic acids research. Supplement (2001) 2003;(3):181-2.
2003: Xu Yan; Sugiyama Hiroshi
Photoreactivity of 5-iodouracil-containing telomeric DNA.
Nucleic acids research. Supplement (2001) 2003;(3):71-2.
2003: Ayame Hirohito; Saito Takashi; Bando Toshikazu; Fukuda Noboru; Sugiyama Hiroshi
Fmoc solid-phase synthesis and its application to pyrrole-imidazole polyamides.
Nucleic acids research. Supplement (2001) 2003;(3):67-8.
2002: Xu Yan; Kino Katsuhito; Sugiyama Hiroshi
The conformational study of two carbocyclic nucleosides: why carbocyclic nucleic acids (CarNAs) form more stable duplexes with RNA than DNA does.
Journal of biomolecular structure & dynamics 2002;20(3):437-46.
2002: Bando Toshikazu; Narita Akihiko; Saito Isao; Sugiyama Hiroshi
Molecular design of a pyrrole-imidazole hairpin polyamides for effective DNA alkylation.
Chemistry (Weinheim an der Bergstrasse, Germany) 2002;8(20):4781-90.
2002: Fujimoto Kazuhisa; Iida Hirokazu; Kawakami Masako; Bando Toshikazu; Tao Zhi-Fu; Sugiyama Hiroshi
Sequence-specific protection of plasmid DNA from restriction endonuclease hydrolysis by pyrrole-imidazole-cyclopropapyrroloindole conjugates.
Nucleic acids research 2002;30(17):3748-53.
2002: Miyabe Izumi; Zhang Qiu-Mei; Kino Katsuhito; Sugiyama Hiroshi; Takao Masashi; Yasui Akira; Yonei Shuji
Identification of 5-formyluracil DNA glycosylase activity of human hNTH1 protein.
Nucleic acids research 2002;30(15):3443-8.
2002: Hashiguchi K; Zhang Q M; Sugiyama H; Ikeda S; Yonei S
Characterization of 2-hydroxyadenine DNA glycosylase activity of Escherichia coli MutY protein.
International journal of radiation biology 2002;78(7):585-92.
2002: Oyoshi Takanori; Wang Andrew H-J; Sugiyama Hiroshi
Photoreactivity of 5-iodouracil-containing DNA-Sso7d complex in solution: the protein-induced DNA kink causes intrastrand hydrogen abstraction from the 5-methyl of thymine at the 5' side.
Journal of the American Chemical Society 2002;124(10):2086-7.
2002: Oyoshi Takanori; Kawakami Wakana; Bando Toshikazu; Narita Akihiko; Sugiyama Hiroshi
Regulation of gene expression by sequence-specific alkylating polyamide.
Nucleic acids research. Supplement (2001) 2002;(2):259-60.
2002: Narita Akihiko; Bando Toshikazu; Sugiyama Hiroshi
Molecular design of hairpin polyamide possessing sequence-specific alkylation activity.
Nucleic acids research. Supplement (2001) 2002;(2):109-10.
2001: Miyabe I; Zhang Q M; Sugiyama H; Kino K; Yonei S
Mutagenic effects of 5-formyluracil on a plasmid vector during replication in Escherichia coli.
International journal of radiation biology 2001;77(1):53-8.
2001: Oyoshi T; Sugiyama H
Photoreactivity of 5-iodouracil-containing DNA-Z alpha complex.
Nucleic acids research. Supplement (2001) 2001;(1):123-4.
2000: Zhang Q M; Miyabe I; Matsumoto Y; Kino K; Sugiyama H; Yonei S
Identification of repair enzymes for 5-formyluracil in DNA. Nth, Nei, and MutM proteins of Escherichia coli.
The Journal of biological chemistry 2000;275(45):35471-7.
2000: Kino K; Sugiyama H
GC-->CG transversion mutation might be caused by 8-oxoguanine oxidation product.
Nucleic acids symposium series 2000;(44):139-40.
2000: Bando T; Iida H; Saito I; Sugiyama H
The synthesis of pyrrole(Py)/imidazole(Im) polyamide CPI conjugates which possess DNA interstrand cross-linking activity.
Nucleic acids symposium series 2000;(44):45-6.
1999: Sugiyama H; Murata K; Iuchi I; Nomura K; Yamagami K
Formation of mature egg envelope subunit proteins from their precursors (choriogenins) in the fish, Oryzias latipes: loss of partial C-terminal sequences of the choriogenins.
Journal of biochemistry 1999;125(3):469-75.
1999: Zhang Q M; Sugiyama H; Miyabe I; Matsuda S; Kino K; Saito I; Yonei S
Replication in vitro and cleavage by restriction endonuclease of 5-formyluracil- and 5-hydroxymethyluracil-containing oligonucleotides.
International journal of radiation biology 1999;75(1):59-65.
1999: Oyoshi T; Sugiyama H; Wang A H
Photoreactivity of 5-iodouracil-containing DNA-Sso7d complex.
Nucleic acids symposium series 1999;(42):171-2.
1999: Ikeda S; Saito I; Sugiyama H
Cleavage of parallel-stranded DNA duplex by peplomycin metal complexes.
Nucleic acids symposium series 1999;(42):41-2.
1998: Sugiyama H; Yasumasu S; Murata K; Iuchi I; Yamagami K
The third egg envelope subunit in fish: cDNA cloning and analysis, and gene expression.
Development, growth & differentiation 1998;40(1):35-45.
1997: Katahira J; Sugiyama H; Inoue N; Horiguchi Y; Matsuda M; Sugimoto N
Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo.
The Journal of biological chemistry 1997;272(42):26652-8.
1997: Zhang Q M; Sugiyama H; Miyabe I; Matsuda S; Saito I; Yonei S
Replication of DNA templates containing 5-formyluracil, a major oxidative lesion of thymine in DNA.
Nucleic acids research 1997;25(20):3969-73.
1997: Murata K; Sugiyama H; Yasumasu S; Iuchi I; Yasumasu I; Yamagami K
Cloning of cDNA and estrogen-induced hepatic gene expression for choriogenin H, a precursor protein of the fish egg envelope (chorion).
Proceedings of the National Academy of Sciences of the United States of America 1997;94(5):2050-5.
1997: Kawai K; Sugiyama H; Saito I
Photoreaction of 5-halouracil-containing Z-form DNA.
Nucleic acids symposium series 1997;(37):93-4.
1997: Ozeki Y; Sugiyama H; Saito I
Cooperative alkylation by duocarmycin A-distamycin A heterodimer.
Nucleic acids symposium series 1997;(37):91-2.
1997: Kino K; Sugiyama H; Saito I
Analysis of guanine oxidation product via electron transfer in 5'-d(TTGGTA)-3'.
Nucleic acids symposium series 1997;(37):39-40.
1996: Sugiyama H; Lian C; Isomura M; Saito I; Wang A H
Distamycin A modulates the sequence specificity of DNA alkylation by duocarmycin A.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(25):14405-10.
1996: Sugiyama H; Murata K; Iuchi I; Yamagami K
Evaluation of solubilizing methods of the egg envelope of the fish, Oryzias latipes, and partial determination of amino acid sequence of its subunit protein, ZI-3.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 1996;114(1):27-33.
1996: Sugiyama H; Kawai K; Matsunaga A; Fujimoto K; Saito I; Robinson H; Wang A H
Synthesis, structure and thermodynamic properties of 8-methylguanine-containing oligonucleotides: Z-DNA under physiological salt conditions.
Nucleic acids research 1996;24(7):1272-8.
1996: Sugiyama H; Natori S
Transmethylation reaction is essential for Sarcophaga lectin gene activation.
Journal of biochemistry 1996;119(2):354-9.
1995: Sugiyama H
[Mechanism of oxidative DNA strand scission]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1995;40(10):1444-56.
1995: Saito I; Takayama M; Nakamura T; Sugiyama H; Komeda Y; Iwasaki M
The most electron-donating sites in duplex DNA: guanine-guanine stacking rule.
Nucleic acids symposium series 1995;(34):191-2.
1995: Isomura M; Sugiyama H; Saito I
Efficient guanine alkylation through cooperative heterodimeric formation of duocarmycin A and distamycin A.
Nucleic acids symposium series 1995;(34):47-8.
1995: Komeda Y; Sakata K; Sugiyama H; Saito I
Synthesis of oligonucleotides containing a carbocyclic nucleoside.
Nucleic acids symposium series 1995;(34):43-4.
1995: Kawai K; Sugiyama H; Fujimoto K; Saito I
8-Methylguanine-containing oligonucleotides: useful structural constraint for Z form DNA.
Nucleic acids symposium series 1995;(34):33-4.
1995: Hatano K; Sugiyama H; Saito I
Photoreaction of 5'-halouracil-containing DNA. A novel photoproduct at 5'BrU-pyrimidine-3' sequence.
Nucleic acids symposium series 1995;(34):31-2.
1995: Fujimoto K; Sugiyama H; Saito I
Photoreaction of 5-bromouracil-containing DNA.
Nucleic acids symposium series 1995;(34):25-6.
1994: Sugiyama H; Natori S
Induction of glutathione metabolism in the fat body of Sarcophaga peregrina by integumental injury.
Journal of biochemistry 1994;116(5):1171-5.
1994: Sugiyama H; Fujiwara T; Ura A; Tashiro T; Yamamoto K; Kawanishi S; Saito I
Chemistry of thermal degradation of abasic sites in DNA. Mechanistic investigation on thermal DNA strand cleavage of alkylated DNA.
Chemical research in toxicology 1994;7(5):673-83.
1993: Yamamoto K; Sugiyama H; Kawanishi S
Concerted DNA recognition and novel site-specific alkylation by duocarmycin A with distamycin A.
Biochemistry 1993;32(4):1059-66.
1993: Sugiyama H; Fujimoto K; Hatano K; Ohmori K; Saito I
Chemistry of oxidative DNA strand scission.
Nucleic acids symposium series 1993;(29):125-6.
1992: Sugiyama H; Yamaguchi E; Yamashita K; Fujimoto K; Tsutsumi Y; Saito I
Photochemical deoxyribose C2' oxidation in 5-iodouracil-containing hexanucleotide.
Nucleic acids symposium series 1992;(27):7-8.
1991: Sugiyama H; Natori S
A novel mechanism of Sarcophaga lectin gene expression. Possible involvement of oxidation of the sulfhydryl group of a fat-body protein.
European journal of biochemistry / FEBS 1991;200(2):495-500.
1991: Sugiyama H; Lam C K; Hosoda M; Saito I
Site specific covalent alkylation of DNA by antitumor antibiotics, duocarmycin A and kapurimycin A3.
Nucleic acids symposium series 1991;(25):75-6.
1990: Sugiyama H; Fujiwara T; Kawabata H; Saito I; Hirayama N; Yoda N
DNA strand scission by neocarzinostatin: molecular recognition process responsible for site-specificity.
Nucleic acids symposium series 1990;(22):55-6.
1989: Sugiyama H; Kawabata H; Fujiwara T; Dannoue Y; Tashiro T; Matsuura T; Saito I
DNA strand scission by antitumor antibiotics. Detection of C-4'-hydroxylated abasic sites in DNA.
Nucleic acids symposium series 1989;(21):51-2.

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