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Yuichi Sugiyama

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Toru Yamada; Makiko Kusama; Yuichi Sugiyama; Yuka Watanabe; Shunsuke Ono
Factors associated with spontaneous reporting of adverse drug reactions in Japan.
Kazuya Maeda; Yuichi Sugiyama
Transporter biology in drug approval: regulatory aspects.
Kenta Yoshida; Junichi Takano; Yoshihide Hayashizaki; Ichiro Ieiri; Yuri Ishizu; Alexander Lezhava; Kazuya Maeda; Yuichi Sugiyama
Direct and rapid genotyping of SLCO1B1 388A>G and 521T>C in human blood specimens using the SmartAmp-2 method.

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2013: Toru Yamada; Makiko Kusama; Yuichi Sugiyama; Yuka Watanabe; Shunsuke Ono
Factors associated with spontaneous reporting of adverse drug reactions in Japan.
Pharmacoepidemiology and drug safety 2013;22(5):468-76.
2013: Kazuya Maeda; Yuichi Sugiyama
Transporter biology in drug approval: regulatory aspects.
Molecular aspects of medicine 2013;34(2-3):711-8.
2013: Kenta Yoshida; Junichi Takano; Yoshihide Hayashizaki; Ichiro Ieiri; Yuri Ishizu; Alexander Lezhava; Kazuya Maeda; Yuichi Sugiyama
Direct and rapid genotyping of SLCO1B1 388A>G and 521T>C in human blood specimens using the SmartAmp-2 method.
The AAPS journal 2013;15(2):618-22.
2013: Yuichiro Imamura; Katsuhisa Inoue; Takashi Izumi; Atsushi Kurihara; Hiroyuki Kusuhara; Nobuyuki Murayama; Noriko Okudaira; Hiroaki Yuasa; Yuichi Sugiyama
Effect of the fluoroquinolone antibacterial agent DX-619 on the apparent formation and renal clearances of 6β-hydroxycortisol, an endogenous probe for CYP3A4 inhibition, in healthy subjects.
Pharmaceutical research 2013;30(2):447-57.
2013: Kenta Yoshida; Kazuya Maeda; Yuichi Sugiyama
Hepatic and intestinal drug transporters: prediction of pharmacokinetic effects caused by drug-drug interactions and genetic polymorphisms.
Annual review of pharmacology and toxicology 2013;53():581-612.
2012: S Ito; T Kondo; Y Kumagai; Hiroyuki Kusuhara; Y Moriyama; H Nakayama; S Horita; K Inoue; K Tanabe; H Yuasa; Yuichi Sugiyama
N-methylnicotinamide is an endogenous probe for evaluation of drug-drug interactions involving multidrug and toxin extrusions (MATE1 and MATE2-K).
Clinical pharmacology and therapeutics 2012;92(5):635-41.
2012: Hiroyuki Kusuhara; Kazuya Maeda; Hiroshi Mayahara; Nozomi Morimoto; Mariko Morishita; Takuya Fujita; Shinya Fukizawa; Hidetoshi Furuie; Ichiro Ieiri; Akihiro Inano; Kiminobu Sumita; Akihiro Sunagawa; Chunyong Wu; Saiko Yamada; Yuichi Sugiyama
Pharmacokinetic interaction study of sulphasalazine in healthy subjects and the impact of curcumin as an in vivo inhibitor of BCRP.
British journal of pharmacology 2012;166(6):1793-803.
2012: Ichiro Ieiri; Shin Irie; Kazuhide Iwasaki; Miyuki Kimura; Kazuya Maeda; Mayuko Miyagawa; Tomohiro Sasaki; Takeshi Chiyoda; Yohei Doi; Takeshi Hirota; Yuichi Sugiyama
Microdosing clinical study: pharmacokinetic, pharmacogenomic (SLCO2B1), and interaction (grapefruit juice) profiles of celiprolol following the oral microdose and therapeutic dose.
Journal of clinical pharmacology 2012;52(7):1078-89.
2012: Takashi Misawa; Yuichi Sugiyama; Hisamitsu Hayashi; Makoto Makishima; Yuichi Hashimoto
E297G mutated bile salt export pump (BSEP) function enhancers derived from GW4064: structural development study and separation from farnesoid X receptor-agonistic activity.
Bioorganic & medicinal chemistry letters 2012;22(12):3962-6.
2012: K Yoshida; K Maeda; Yuichi Sugiyama
Transporter-mediated drug--drug interactions involving OATP substrates: predictions based on in vitro inhibition studies.
Clinical pharmacology and therapeutics 2012;91(6):1053-64.
2012: Hisamitsu Hayashi; Ikuo Horii; Reiko Horikawa; Kaori Inamura; Hironori Nagasaka; Sotaro Naoi; Kensuke Aida; Tamio Fukushima; Asami Hattori; Tomozumi Takatani; Takashi Yabuki; Yuichi Sugiyama
AP2 adaptor complex mediates bile salt export pump internalization and modulates its hepatocanalicular expression and transport function.
Hepatology (Baltimore, Md.) 2012;55(6):1889-900.
2012: Takashi Misawa; Yuichi Sugiyama; Hisamitsu Hayashi; Yuichi Hashimoto
Discovery and structural development of small molecules that enhance transport activity of bile salt export pump mutant associated with progressive familial intrahepatic cholestasis type 2.
Bioorganic & medicinal chemistry 2012;20(9):2940-9.
2012: Hisamitsu Hayashi; Reiko Horikawa; Tadahaya Mizuno; Hironori Nagasaka; Hajime Takikawa; Takashi Yabuki; Yuichi Sugiyama
4-Phenylbutyrate modulates ubiquitination of hepatocanalicular MRP2 and reduces serum total bilirubin concentration.
Journal of hepatology 2012;56(5):1136-44.
2012: Hisamitsu Hayashi; Masakazu Hirouchi; Shinobu Imajoh-Ohmi; Ayano Kondo; Kiyotaka Kubo; Takayuki Nakagawa; Sotaro Naoi; Toru Nishikawa; Hiroyuki Fukuda; Asami Hattori; Takashi Yabuki; Yuichi Sugiyama
Sorting nexin 27 interacts with multidrug resistance-associated protein 4 (MRP4) and mediates internalization of MRP4.
The Journal of biological chemistry 2012;287(18):15054-65.
2012: Yuka Hirai; Taro Ishibashi; Makiko Kusama; Yuichi Sugiyama; Yosuke Yamanaka; Shunsuke Ono
Analysis of the success rates of new drug development in Japan and the lag behind the US.
Health policy (Amsterdam, Netherlands) 2012;104(3):241-6.
2012: Li Jin; Ryota Kikuchi; Hiroyuki Kusuhara; Takami Saji; Yuichi Sugiyama
Regulation of tissue-specific expression of renal organic anion transporters by hepatocyte nuclear factor 1 α/β and DNA methylation.
The Journal of pharmacology and experimental therapeutics 2012;340(3):648-55.
2012: Sumito Ito; Hiroyuki Kusuhara; Junko Toyoshima; Miyu Yokochi; Hiroaki Yuasa; Katsuhisa Inoue; Yuichi Sugiyama
Competitive inhibition of the luminal efflux by multidrug and toxin extrusions, but not basolateral uptake by organic cation transporter 2, is the likely mechanism underlying the pharmacokinetic drug-drug interactions caused by cimetidine in the kidney.
The Journal of pharmacology and experimental therapeutics 2012;340(2):393-403.
2012: Yoshihisa Shitara; Yuichi Sugiyama; Kumiko Takeuchi; Satomi Wada; Yoshiko Nagamatsu; Toshiharu Horie
Long-lasting inhibitory effects of cyclosporin A, but not tacrolimus, on OATP1B1- and OATP1B3-mediated uptake.
Drug metabolism and pharmacokinetics 2012;27(4):368-78.
2011: Hiroshi Kodaira; Hiroyuki Kusuhara; Takuya Fujita; Eiichi Fuse; Junko Ushiki; Yuichi Sugiyama
Quantitative evaluation of the impact of active efflux by p-glycoprotein and breast cancer resistance protein at the blood-brain barrier on the predictability of the unbound concentrations of drugs in the brain using cerebrospinal fluid concentration as a surrogate.
The Journal of pharmacology and experimental therapeutics 2011;339(3):935-44.
2011: Ran Okada; Zenzaburo Tozuka; Shinsuke Aoyama; Akira Hiratsuka; Toshihiko Ikeda; Hiroyuki Kusuhara; Kazuya Maeda; Takahito Nishiyama; Yuichi Sugiyama
Involvement of different human glutathione transferase isoforms in the glutathione conjugation of reactive metabolites of troglitazone.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(12):2290-7.
2011: K Maeda; N Yamane; K Yoshida; Y Azuma; T Fujita; Y Haruyama; Y Ikeda; Y Kumagai; Yuichi Sugiyama
Identification of the rate-determining process in the hepatic clearance of atorvastatin in a clinical cassette microdosing study.
Clinical pharmacology and therapeutics 2011;90(4):575-81.
2011: M Yokota; Yuichi Sugiyama; M Kusama; S Ono
Analysis of labeling decisions regarding therapeutic indications during new drug application reviews in Japan.
Clinical pharmacology and therapeutics 2011;90(3):432-41.
2011: Naoki Kotani; Hiroyuki Kusuhara; Kazuya Maeda; Yi-an Bi; Li-kun Gong; Mariko Hiramatsu; Toshiaki Takezawa; Takao Watanabe; Yuichi Sugiyama
Culture period-dependent changes in the uptake of transporter substrates in sandwich-cultured rat and human hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(9):1503-10.
2011: K Maeda; K Nozawa; Y Oyama; T Fujita; Y Ikeda; Y Kumagai; J Takano; Yuichi Sugiyama
Nonlinear pharmacokinetics of oral quinidine and verapamil in healthy subjects: a clinical microdosing study.
Clinical pharmacology and therapeutics 2011;90(2):263-70.
2011: Tadahaya Mizuno; Sotaro Naoi; Hisamitsu Hayashi; Yuichi Sugiyama
Ubiquitination is associated with lysosomal degradation of cell surface-resident ATP-binding cassette transporter A1 (ABCA1) through the endosomal sorting complex required for transport (ESCRT) pathway.
Hepatology (Baltimore, Md.) 2011;54(2):631-43.
2011: Naoe Yamane; Zenzaburo Tozuka; Toshihiko Ikeda; Makiko Kusama; Kazuya Maeda; Yuichi Sugiyama
Clinical relevance of liquid chromatography tandem mass spectrometry as an analytical method in microdose clinical studies.
Pharmaceutical research 2011;28(8):1963-72.
2011: Yuichi Sugiyama; Shinji Yamashita
Impact of microdosing clinical study -- why necessary and how useful?
Advanced drug delivery reviews 2011;63(7):494-502.
2011: Hiroyuki Kusuhara; S Ito; Y Kumagai; M Jiang; T Shiroshita; Y Moriyama; K Inoue; H Yuasa; Yuichi Sugiyama
Effects of a MATE protein inhibitor, pyrimethamine, on the renal elimination of metformin at oral microdose and at therapeutic dose in healthy subjects.
Clinical pharmacology and therapeutics 2011;89(6):837-44.
2011: Takao Watanabe; Hiroyuki Kusuhara; Tomoko Watanabe; Yasuyuki Debori; Kazuya Maeda; Tsunenori Kondo; Hideki Nakayama; Shigeru Horita; Brian W Ogilvie; Andrew Parkinson; Zhuohan Hu; Yuichi Sugiyama
Prediction of the overall renal tubular secretion and hepatic clearance of anionic drugs and a renal drug-drug interaction involving organic anion transporter 3 in humans by in vitro uptake experiments.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(6):1031-8.
2011: Mari Miyajima; Hiroyuki Kusuhara; Miki Fujishima; Yasuhisa Adachi; Yuichi Sugiyama
Organic anion transporter 3 mediates the efflux transport of an amphipathic organic anion, dehydroepiandrosterone sulfate, across the blood-brain barrier in mice.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(5):814-9.
2011: Natsuki Hori; Hisamitsu Hayashi; Yuichi Sugiyama
Calpain-mediated cleavage negatively regulates the expression level of ABCG1.
Atherosclerosis 2011;215(2):383-91.
2010: Toru Yamada; Makiko Kusama; Yuka Hirai; Frank Arnold; Yuichi Sugiyama; Shunsuke Ono
Analysis of pharmaceutical safety-related regulatory actions in Japan: do tradeoffs exist between safer drugs and launch delay?
The Annals of pharmacotherapy 2010;44(12):1976-85.
2010: Takao Watanabe; Hiroyuki Kusuhara; Yuichi Sugiyama
Application of physiologically based pharmacokinetic modeling and clearance concept to drugs showing transporter-mediated distribution and clearance in humans.
Journal of pharmacokinetics and pharmacodynamics 2010;37(6):575-90.
2010: T Ishibashi; Kazuki Yasuda; M Kusama; Yuichi Sugiyama; S Ono
Clinical development and review times for new drugs in Japan: associated factors.
Clinical pharmacology and therapeutics 2010;88(4):487-91.
2010: Ran Okada; Yuri Ishizu; Ryuta Endo; Alexander Lezhava; Ichiro Ieiri; Hiroyuki Kusuhara; Yuichi Sugiyama; Yoshihide Hayashizaki
Direct and rapid genotyping of glutathione-S-transferase M1 and T1 from human blood specimens using the SmartAmp2 method.
Drug metabolism and disposition: the biological fate of chemicals 2010;38(10):1636-9.
2010: Ryota Kikuchi; Shintaro Yagi; Hiroyuki Kusuhara; Satoki Imai; Yuichi Sugiyama; Kunio Shiota
Genome-wide analysis of epigenetic signatures for kidney-specific transporters.
Kidney international 2010;78(6):569-77.
2010: T Kato; Hisamitsu Hayashi; Yuichi Sugiyama
Short- and medium-chain fatty acids enhance the cell surface expression and transport capacity of the bile salt export pump (BSEP/ABCB11).
Biochimica et biophysica acta 2010;1801(9):1005-12.
2010: Takashi Ito; Masayuki Takahashi; Osamu Okazaki; Yuichi Sugiyama
Investigation of the effect of mutations of rat albumin on the binding affinity to the alpha(4)beta(1) integrin antagonist, 4-[1-[3-chloro-4-[N'-(2-methylphenyl)ureido]phenylacetyl]-(4S)-fluoro-(2S)-pyrrolidine-2-yl]methoxybenzoic acid (D01-4582), using recombinant rat albumins.
Molecular pharmaceutics 2010;7(4):1254-9.
2010: Makiko Kusama; Kouta Toshimoto; Kazuya Maeda; Yuka Hirai; Satoki Imai; Koji Chiba; Yutaka Akiyama; Yuichi Sugiyama
In silico classification of major clearance pathways of drugs with their physiochemical parameters.
Drug metabolism and disposition: the biological fate of chemicals 2010;38(8):1362-70.
2010: Hiroyuki Kusuhara; Yuichi Sugiyama
Pharmacokinetic modeling of the hepatobiliary transport mediated by cooperation of uptake and efflux transporters.
Drug metabolism reviews 2010;42(3):539-50.
2010: Yoshiaki Kitamura; Hiroyuki Kusuhara; Yuichi Sugiyama
Basolateral efflux mediated by multidrug resistance-associated protein 3 (Mrp3/Abcc3) facilitates intestinal absorption of folates in mouse.
Pharmaceutical research 2010;27(4):665-72.
2010: Sumito Ito; Hiroyuki Kusuhara; Yushun Kuroiwa; Chunyong Wu; Yoshinori Moriyama; Katsuhisa Inoue; Tsunenori Kondo; Hiroaki Yuasa; Hideki Nakayama; Shigeru Horita; Yuichi Sugiyama
Potent and specific inhibition of mMate1-mediated efflux of type I organic cations in the liver and kidney by pyrimethamine.
The Journal of pharmacology and experimental therapeutics 2010;333(1):341-50.
2010: Sayaka Ichihara; Ryota Kikuchi; Hiroyuki Kusuhara; Satoki Imai; Kazuya Maeda; Yuichi Sugiyama
DNA methylation profiles of organic anion transporting polypeptide 1B3 in cancer cell lines.
Pharmaceutical research 2010;27(3):510-6.
2010: Yasuo Hirai; Hirofumi Kinoshita; M Kusama; Kazuki Yasuda; Yuichi Sugiyama; S Ono
Delays in new drug applications in Japan and industrial R&D strategies.
Clinical pharmacology and therapeutics 2010;87(2):212-8.
2010: Yoshiaki Kitamura; Hiroyuki Kusuhara; Yuichi Sugiyama
Functional characterization of multidrug resistance-associated protein 3 (mrp3/abcc3) in the basolateral efflux of glucuronide conjugates in the mouse small intestine.
The Journal of pharmacology and experimental therapeutics 2010;332(2):659-66.
2010: Takao Watanabe; Hiroyuki Kusuhara; Kazuya Maeda; Hiroshi Kanamaru; Yoshikazu Saito; Zhuohan Hu; Yuichi Sugiyama
Investigation of the rate-determining process in the hepatic elimination of HMG-CoA reductase inhibitors in rats and humans.
Drug metabolism and disposition: the biological fate of chemicals 2010;38(2):215-22.
2010: Kazuya Maeda; Yuichi Sugiyama
The use of hepatocytes to investigate drug uptake transporters.
Methods in molecular biology (Clifton, N.J.) 2010;640():327-53.
2010: Atsushi Ose; Hiroyuki Kusuhara; Chihiro Endo; Kimio Tohyama; Mari Miyajima; Satoshi Kitamura; Yuichi Sugiyama
Functional characterization of mouse organic anion transporting peptide 1a4 in the uptake and efflux of drugs across the blood-brain barrier.
Drug metabolism and disposition: the biological fate of chemicals 2010;38(1):168-76.
2009: Masakazu Hirouchi; Hiroyuki Kusuhara; Reiko Onuki; Brian W Ogilvie; Andrew Parkinson; Yuichi Sugiyama
Construction of triple-transfected cells [organic anion-transporting polypeptide (OATP) 1B1/multidrug resistance-associated protein (MRP) 2/MRP3 and OATP1B1/MRP2/MRP4] for analysis of the sinusoidal function of MRP3 and MRP4.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(10):2103-11.
2009: Tomoko Watanabe; Kazuya Maeda; Tsunenori Kondo; Hideki Nakayama; Shigeru Horita; Hiroyuki Kusuhara; Yuichi Sugiyama
Prediction of the hepatic and renal clearance of transporter substrates in rats using in vitro uptake experiments.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(7):1471-9.
2009: Yoshihisa Shitara; Yoshiko Nagamatsu; Satomi Wada; Yuichi Sugiyama; Toshiharu Horie
Long-lasting inhibition of the transporter-mediated hepatic uptake of sulfobromophthalein by cyclosporin a in rats.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(6):1172-8.
2009: Mayuko Miyagawa; Kazuya Maeda; Akinori Aoyama; Yuichi Sugiyama
The eighth and ninth transmembrane domains in organic anion transporting polypeptide 1B1 affect the transport kinetics of estrone-3-sulfate and estradiol-17beta-D-glucuronide.
The Journal of pharmacology and experimental therapeutics 2009;329(2):551-7.
2009: KX Liu; Yukio Kato; Kunio Matsumoto; Toshikazu Nakamura; TI Kaku; Yuichi Sugiyama
Characterization of the enhancing effect of protamine on the proliferative activity of hepatocyte growth factor in rat hepatocytes.
Pharmaceutical research 2009;26(4):1012-21.
2009: Makiko Kusama; Kazuya Maeda; Koji Chiba; Akinori Aoyama; Yuichi Sugiyama
Prediction of the effects of genetic polymorphism on the pharmacokinetics of CYP2C9 substrates from in vitro data.
Pharmaceutical research 2009;26(4):822-35.
2009: Soichiro Matsushima; Kazuya Maeda; Katsuhisa Inoue; Kin-ya Ohta; Hiroaki Yuasa; Tsunenori Kondo; Hideki Nakayama; Shigeru Horita; Hiroyuki Kusuhara; Yuichi Sugiyama
The inhibition of human multidrug and toxin extrusion 1 is involved in the drug-drug interaction caused by cimetidine.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(3):555-9.
2009: Satoki Imai; Ryota Kikuchi; Hiroyuki Kusuhara; Shintaro Yagi; Kunio Shiota; Yuichi Sugiyama
Analysis of DNA methylation and histone modification profiles of liver-specific transporters.
Molecular pharmacology 2009;75(3):568-76.
2009: Atsushi Ose; Mototsugu Ito; Hiroyuki Kusuhara; Kenzo Yamatsugu; Motomu Kanai; Masakatsu Shibasaki; Masakiyo Hosokawa; John D Schuetz; Yuichi Sugiyama
Limited brain distribution of [3R,4R,5S]-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate phosphate (Ro 64-0802), a pharmacologically active form of oseltamivir, by active efflux across the blood-brain barrier mediated by organic anion transporter 3 (Oat3/Slc22a8) and multidrug resistance-associated protein 4 (Mrp4/Abcc4).
Drug metabolism and disposition: the biological fate of chemicals 2009;37(2):315-21.
2009: Takao Watanabe; Hiroyuki Kusuhara; Kazuya Maeda; Yoshihisa Shitara; Yuichi Sugiyama
Physiologically based pharmacokinetic modeling to predict transporter-mediated clearance and distribution of pravastatin in humans.
The Journal of pharmacology and experimental therapeutics 2009;328(2):652-62.
2009: Akihiro Hisaka; Mikihiro Kusama; Yoshiyuki Ohno; Yuichi Sugiyama; Hiroshi Suzuki
A proposal for a pharmacokinetic interaction significance classification system (PISCS) based on predicted drug exposure changes and its potential application to alert classifications in product labelling.
Clinical pharmacokinetics 2009;48(10):653-66.
2009: Yuichi Sugiyama
Effective use of microdosing and Positron Emission Tomography (PET) studies on new drug discovery and development.
Drug metabolism and pharmacokinetics 2009;24(2):127-9.
2009: Hiroyuki Kusuhara; Yuichi Sugiyama
In vitro-in vivo extrapolation of transporter-mediated clearance in the liver and kidney.
Drug metabolism and pharmacokinetics 2009;24(1):37-52.
2008: Yoshiaki Kitamura; Masakazu Hirouchi; Hiroyuki Kusuhara; John D Schuetz; Yuichi Sugiyama
Increasing systemic exposure of methotrexate by active efflux mediated by multidrug resistance-associated protein 3 (mrp3/abcc3).
The Journal of pharmacology and experimental therapeutics 2008;327(2):465-73.
2008: Satoshi Kitamura; Kazuya Maeda; Yi Wang; Yuichi Sugiyama
Involvement of multiple transporters in the hepatobiliary transport of rosuvastatin.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(10):2014-23.
2008: Kazuhiro Kobayashi; Kousei Ito; Tappei Takada; Yuichi Sugiyama; Hiroshi Suzuki
Functional analysis of nonsynonymous single nucleotide polymorphism type ATP-binding cassette transmembrane transporter subfamily C member 3.
Pharmacogenetics and genomics 2008;18(9):823-33.
2008: Satoshi Kitamura; Kazuya Maeda; Yuichi Sugiyama
Recent progresses in the experimental methods and evaluation strategies of transporter functions for the prediction of the pharmacokinetics in humans.
Naunyn-Schmiedeberg's archives of pharmacology 2008;377(4-6):617-28.
2008: Junichi Enokizono; Hiroyuki Kusuhara; Atsushi Ose; Alfred H Schinkel; Yuichi Sugiyama
Quantitative investigation of the role of breast cancer resistance protein (Bcrp/Abcg2) in limiting brain and testis penetration of xenobiotic compounds.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(6):995-1002.
2008: Yoshiaki Kitamura; Hisao Koto; Shinobu Matsuura; Takeshi Kawabata; Hiroshi Tsuchiya; Hiroyuki Kusuhara; Hajime Tsujimoto; Yuichi Sugiyama
Modest effect of impaired P-glycoprotein on the plasma concentrations of fexofenadine, quinidine, and loperamide following oral administration in collies.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(5):807-10.
2008: Soichiro Matsushima; Kazuya Maeda; Hisamitsu Hayashi; Yasuyuki Debori; Alfred H Schinkel; John D Schuetz; Hiroyuki Kusuhara; Yuichi Sugiyama
Involvement of multiple efflux transporters in hepatic disposition of fexofenadine.
Molecular pharmacology 2008;73(5):1474-83.
2008: Soichiro Matsushima; Kazuya Maeda; Naoki Ishiguro; Takashi Igarashi; Yuichi Sugiyama
Investigation of the inhibitory effects of various drugs on the hepatic uptake of fexofenadine in humans.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(4):663-9.
2008: Atsushi Ose; Hiroyuki Kusuhara; Kenzo Yamatsugu; Motomu Kanai; Masakatsu Shibasaki; Takuya Fujita; Akira Yamamoto; Yuichi Sugiyama
P-glycoprotein restricts the penetration of oseltamivir across the blood-brain barrier.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(2):427-34.
2008: Takami Saji; Ryota Kikuchi; Hiroyuki Kusuhara; Insook Kim; Frank J Gonzalez; Yuichi Sugiyama
Transcriptional regulation of human and mouse organic anion transporter 1 by hepatocyte nuclear factor 1 alpha/beta.
The Journal of pharmacology and experimental therapeutics 2008;324(2):784-90.
2008: Kazuya Maeda; Yuichi Sugiyama
Impact of genetic polymorphisms of transporters on the pharmacokinetic, pharmacodynamic and toxicological properties of anionic drugs.
Drug metabolism and pharmacokinetics 2008;23(4):223-35.
2007: Ryota Kikuchi; Hiroyuki Kusuhara; Naka Hattori; Insook Kim; Kunio Shiota; Frank J Gonzalez; Yuichi Sugiyama
Regulation of tissue-specific expression of the human and mouse urate transporter 1 gene by hepatocyte nuclear factor 1 alpha/beta and DNA methylation.
Molecular pharmacology 2007;72(6):1619-25.
2007: Akihiro Yamada; Kazuya Maeda; Emi Kamiyama; Daisuke Sugiyama; Tsunenori Kondo; Yoshiyuki Shiroyanagi; Hayakazu Nakazawa; Teruo Okano; Masashi Adachi; John D Schuetz; Yasuhisa Adachi; Zhuohan Hu; Hiroyuki Kusuhara; Yuichi Sugiyama
Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(12):2166-76.
2007: Junichi Enokizono; Hiroyuki Kusuhara; Yuichi Sugiyama
Effect of breast cancer resistance protein (Bcrp/Abcg2) on the disposition of phytoestrogens.
Molecular pharmacology 2007;72(4):967-75.
2007: Tomohiro Ando; Hiroyuki Kusuhara; Gracia Merino; Ana I Alvarez; Alfred H Schinkel; Yuichi Sugiyama
Involvement of breast cancer resistance protein (ABCG2) in the biliary excretion mechanism of fluoroquinolones.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(10):1873-9.
2007: Yoshitane Nozaki; Hiroyuki Kusuhara; Tsunenori Kondo; Masahiro Iwaki; Yoshiyuki Shiroyanagi; Hideki Nakayama; Shigeru Horita; Hayakazu Nakazawa; Teruo Okano; Yuichi Sugiyama
Species difference in the inhibitory effect of nonsteroidal anti-inflammatory drugs on the uptake of methotrexate by human kidney slices.
The Journal of pharmacology and experimental therapeutics 2007;322(3):1162-70.
2007: Mototsugu Ito; Reiko Onuki; Yoshio Bando; Masaya Tohyama; Yuichi Sugiyama
Phosphorylated PKR contributes the induction of GRP94 under ER stress.
Biochemical and biophysical research communications 2007;360(3):615-20.
2007: Hisamitsu Hayashi; Yuichi Sugiyama
4-phenylbutyrate enhances the cell surface expression and the transport capacity of wild-type and mutated bile salt export pumps.
Hepatology (Baltimore, Md.) 2007;45(6):1506-16.
2007: Junichi Enokizono; Hiroyuki Kusuhara; Yuichi Sugiyama
Regional expression and activity of breast cancer resistance protein (Bcrp/Abcg2) in mouse intestine: overlapping distribution with sulfotransferases.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(6):922-8.
2007: Lei Ci; Hiroyuki Kusuhara; Masashi Adachi; John D Schuetz; Kenji Takeuchi; Yuichi Sugiyama
Involvement of MRP4 (ABCC4) in the luminal efflux of ceftizoxime and cefazolin in the kidney.
Molecular pharmacology 2007;71(6):1591-7.
2007: Yoshitane Nozaki; Hiroyuki Kusuhara; Tsunenori Kondo; Maki Hasegawa; Yoshiyuki Shiroyanagi; Hayakazu Nakazawa; Teruo Okano; Yuichi Sugiyama
Characterization of the uptake of organic anion transporter (OAT) 1 and OAT3 substrates by human kidney slices.
The Journal of pharmacology and experimental therapeutics 2007;321(1):362-9.
2007: Kazumi Komoriya; Yukio Kato; Yujiro Hayashi; Kazuhiro Ohsuye; Ryuichiro Nishigaki; Yuichi Sugiyama
Characterization of the hepatic disposition of lanoteplase, a rationally designed variant of tissue plasminogen activator in rodents.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(3):469-75.
2007: Tomoki Imaoka; Hiroyuki Kusuhara; Masashi Adachi; John D Schuetz; Kenji Takeuchi; Yuichi Sugiyama
Functional involvement of multidrug resistance-associated protein 4 (MRP4/ABCC4) in the renal elimination of the antiviral drugs adefovir and tenofovir.
Molecular pharmacology 2007;71(2):619-27.
2007: Junichi Enokizono; Hiroyuki Kusuhara; Yuichi Sugiyama
Involvement of breast cancer resistance protein (BCRP/ABCG2) in the biliary excretion and intestinal efflux of troglitazone sulfate, the major metabolite of troglitazone with a cholestatic effect.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(2):209-14.
2007: Hiroyuki Kusuhara; Yuichi Sugiyama
ATP-binding cassette, subfamily G (ABCG family).
Pflügers Archiv : European journal of physiology 2007;453(5):735-44.
2007: Maki Hasegawa; Hiroyuki Kusuhara; Masashi Adachi; John D Schuetz; Kenji Takeuchi; Yuichi Sugiyama
Multidrug resistance-associated protein 4 is involved in the urinary excretion of hydrochlorothiazide and furosemide.
Journal of the American Society of Nephrology : JASN 2007;18(1):37-45.
2006: Yoshihisa Shitara; Yuichi Sugiyama
Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: drug-drug interactions and interindividual differences in transporter and metabolic enzyme functions.
Pharmacology & therapeutics 2006;112(1):71-105.
2006: Akihiro Takano; Tetsuya Suhara; Fumihiko Yasuno; Kazutoshi Suzuki; Hidehiko Takahashi; Takuya Morimoto; Young-Joo Lee; Hiroyuki Kusuhara; Yuichi Sugiyama; Yoshiro Okubo
The antipsychotic sultopride is overdosed--a PET study of drug-induced receptor occupancy in comparison with sulpiride.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2006;9(5):539-45.
2006: Yoko Ikoma; Akihiro Takano; Hiroshi Ito; Hiroyuki Kusuhara; Yuichi Sugiyama; Ryosuke Arakawa; Toshimitsu Fukumura; Ryuji Nakao; Kazutoshi Suzuki; Tetsuya Suhara
Quantitative analysis of 11C-verapamil transfer at the human blood-brain barrier for evaluation of P-glycoprotein function.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2006;47(9):1531-7.
2006: Akihiro Takano; Hiroyuki Kusuhara; Tetsuya Suhara; Ichiro Ieiri; Takuya Morimoto; Young-Joo Lee; Jun Maeda; Yoko Ikoma; Hiroshi Ito; Kazutoshi Suzuki; Yuichi Sugiyama
Evaluation of in vivo P-glycoprotein function at the blood-brain barrier among MDR1 gene polymorphisms by using 11C-verapamil.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2006;47(9):1427-33.
2006: Ryota Kikuchi; Hiroyuki Kusuhara; Naka Hattori; Kunio Shiota; Insook Kim; Frank J Gonzalez; Yuichi Sugiyama
Regulation of the expression of human organic anion transporter 3 by hepatocyte nuclear factor 1alpha/beta and DNA methylation.
Molecular pharmacology 2006;70(3):887-96.
2006: Sachiko Mita; Hiroshi Suzuki; Hidetaka Akita; Hisamitsu Hayashi; Reiko Onuki; Alan F Hofmann; Yuichi Sugiyama
Inhibition of bile acid transport across Na+/taurocholate cotransporting polypeptide (SLC10A1) and bile salt export pump (ABCB 11)-coexpressing LLC-PK1 cells by cholestasis-inducing drugs.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(9):1575-81.
2006: Wakaba Yamashiro; Kazuya Maeda; Masakazu Hirouchi; Yasuhisa Adachi; Zhuohan Hu; Yuichi Sugiyama
Involvement of transporters in the hepatic uptake and biliary excretion of valsartan, a selective antagonist of the angiotensin II AT1-receptor, in humans.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(7):1247-54.
2006: Masaru Hirano; Kazuya Maeda; Yoshihisa Shitara; Yuichi Sugiyama
Drug-drug interaction between pitavastatin and various drugs via OATP1B1.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(7):1229-36.
2006: Shingo Sakamoto; Hiroshi Suzuki; Hiroyuki Kusuhara; Yuichi Sugiyama
Efflux mechanism of taurocholate across the rat intestinal basolateral membrane.
Molecular pharmaceutics 2006;3(3):275-81.
2006: Kazuya Maeda; Ichiro Ieiri; Kuninobu Yasuda; Akiharu Fujino; Hiroaki Fujiwara; Kenji Otsubo; Masaru Hirano; Takao Watanabe; Yoshiaki Kitamura; Hiroyuki Kusuhara; Yuichi Sugiyama
Effects of organic anion transporting polypeptide 1B1 haplotype on pharmacokinetics of pravastatin, valsartan, and temocapril.
Clinical pharmacology and therapeutics 2006;79(5):427-39.
2006: Ying Han; Yuichi Sugiyama
Expression and regulation of breast cancer resistance protein and multidrug resistance associated protein 2 in BALB/c mice.
Biological & pharmaceutical bulletin 2006;29(5):1032-5.
2006: Harunobu Tahara; Hiroyuki Kusuhara; Kazuya Maeda; Hermann Koepsell; Eiichi Fuse; Yuichi Sugiyama
Inhibition of oat3-mediated renal uptake as a mechanism for drug-drug interaction between fexofenadine and probenecid.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(5):743-7.
2006: Yoshihisa Shitara; Toshiharu Horie; Yuichi Sugiyama
Transporters as a determinant of drug clearance and tissue distribution.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2006;27(5):425-46.
2006: Sachiko Mita; Hiroshi Suzuki; Hidetaka Akita; Hisamitsu Hayashi; Reiko Onuki; Alan F Hofmann; Yuichi Sugiyama
Vectorial transport of unconjugated and conjugated bile salts by monolayers of LLC-PK1 cells doubly transfected with human NTCP and BSEP or with rat Ntcp and Bsep.
American journal of physiology. Gastrointestinal and liver physiology 2006;290(3):G550-6.
2006: Harunobu Tahara; Hiroyuki Kusuhara; Michihiro Chida; Eiichi Fuse; Yuichi Sugiyama
Is the monkey an appropriate animal model to examine drug-drug interactions involving renal clearance? Effect of probenecid on the renal elimination of H2 receptor antagonists.
The Journal of pharmacology and experimental therapeutics 2006;316(3):1187-94.
2006: Young-Joo Lee; Jun Maeda; Hiroyuki Kusuhara; Takashi Okauchi; Motoki Inaji; Yuji Nagai; Shigeru Obayashi; Ryuji Nakao; Kazutoshi Suzuki; Yuichi Sugiyama; Tetsuya Suhara
In vivo evaluation of P-glycoprotein function at the blood-brain barrier in nonhuman primates using [11C]verapamil.
The Journal of pharmacology and experimental therapeutics 2006;316(2):647-53.
2006: Kazuya Maeda; Miyuki Kambara; Ying Tian; Alan F Hofmann; Yuichi Sugiyama
Uptake of ursodeoxycholate and its conjugates by human hepatocytes: role of Na(+)-taurocholate cotransporting polypeptide (NTCP), organic anion transporting polypeptide (OATP) 1B1 (OATP-C), and oatp1B3 (OATP8).
Molecular pharmaceutics 2006;3(1):70-7.
2005: Hisamitsu Hayashi; Tappei Takada; Hiroshi Suzuki; Reiko Onuki; Alan F Hofmann; Yuichi Sugiyama
Transport by vesicles of glycine- and taurine-conjugated bile salts and taurolithocholate 3-sulfate: a comparison of human BSEP with rat Bsep.
Biochimica et biophysica acta 2005;1738(1-3):54-62.
2005: Kousei Ito; Hiroshi Suzuki; Toshiharu Horie; Yuichi Sugiyama
Apical/basolateral surface expression of drug transporters and its role in vectorial drug transport.
Pharmaceutical research 2005;22(10):1559-77.
2005: Maki Shimizu; Kaori Fuse; Kazuho Okudaira; Ryuichiro Nishigaki; Kazuya Maeda; Hiroyuki Kusuhara; Yuichi Sugiyama
Contribution of OATP (organic anion-transporting polypeptide) family transporters to the hepatic uptake of fexofenadine in humans.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(10):1477-81.
2005: Harunobu Tahara; Hiroyuki Kusuhara; Hitoshi Endou; Hermann Koepsell; Tomoki Imaoka; Eiichi Fuse; Yuichi Sugiyama
A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters.
The Journal of pharmacology and experimental therapeutics 2005;315(1):337-45.
2005: Masaru Hirano; Kazuya Maeda; Soichiro Matsushima; Yoshitane Nozaki; Hiroyuki Kusuhara; Yuichi Sugiyama
Involvement of BCRP (ABCG2) in the biliary excretion of pitavastatin.
Molecular pharmacology 2005;68(3):800-7.
2005: Soichiro Matsushima; Kazuya Maeda; Chihiro Kondo; Masaru Hirano; Makoto Sasaki; Hiroshi Suzuki; Yuichi Sugiyama
Identification of the hepatic efflux transporters of organic anions using double-transfected Madin-Darby canine kidney II cells expressing human organic anion-transporting polypeptide 1B1 (OATP1B1)/multidrug resistance-associated protein 2, OATP1B1/multidrug resistance 1, and OATP1B1/breast cancer resistance protein.
The Journal of pharmacology and experimental therapeutics 2005;314(3):1059-67.
2005: Tomoko Watanabe; Reiko Onuki; Shinji Yamashita; Kazunari Taira; Yuichi Sugiyama
Construction of a functional transporter analysis system using MDR1 knockdown Caco-2 cells.
Pharmaceutical research 2005;22(8):1287-93.
2005: Masaru Hirano; Kazuya Maeda; Hisamitsu Hayashi; Hiroyuki Kusuhara; Yuichi Sugiyama
Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin.
The Journal of pharmacology and experimental therapeutics 2005;314(2):876-82.
2005: Naomi Morita; Hiroyuki Kusuhara; Yoshitane Nozaki; Hitoshi Endou; Yuichi Sugiyama
Functional involvement of rat organic anion transporter 2 (Slc22a7) in the hepatic uptake of the nonsteroidal anti-inflammatory drug ketoprofen.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(8):1151-7.
2005: Misaki Kuroda; Hiroyuki Kusuhara; Hitoshi Endou; Yuichi Sugiyama
Rapid elimination of cefaclor from the cerebrospinal fluid is mediated by a benzylpenicillin-sensitive mechanism distinct from organic anion transporter 3.
The Journal of pharmacology and experimental therapeutics 2005;314(2):855-61.
2005: Tappei Takada; Hiroshi Suzuki; Yukiko Gotoh; Yuichi Sugiyama
Regulation of the cell surface expression of human BCRP/ABCG2 by the phosphorylation state of Akt in polarized cells.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(7):905-9.
2005: Harunobu Tahara; Hiroyuki Kusuhara; Eiichi Fuse; Yuichi Sugiyama
P-glycoprotein plays a major role in the efflux of fexofenadine in the small intestine and blood-brain barrier, but only a limited role in its biliary excretion.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(7):963-8.
2005: Masakazu Hirouchi; Hiroshi Suzuki; Yuichi Sugiyama
Treatment of hyperbilirubinemia in Eisai hyperbilirubinemic rat by transfecting human MRP2/ABCC2 gene.
Pharmaceutical research 2005;22(4):661-6.
2005: Harunobu Tahara; Masayuki Shono; Hiroyuki Kusuhara; Hajime Kinoshita; Eiichi Fuse; Akira Takadate; Masaki Otagiri; Yuichi Sugiyama
Molecular cloning and functional analyses of OAT1 and OAT3 from cynomolgus monkey kidney.
Pharmaceutical research 2005;22(4):647-60.
2005: Chihiro Kondo; Reiko Onuki; Hiroyuki Kusuhara; Hiroshi Suzuki; Michiko Suzuki; Noriko Okudaira; Maho Kojima; Kazuya Ishiwata; johan jonker; Yuichi Sugiyama
Lack of improvement of oral absorption of ME3277 by prodrug formation is ascribed to the intestinal efflux mediated by breast cancer resistant protein (BCRP/ABCG2).
Pharmaceutical research 2005;22(4):613-8.
2005: Hisamitsu Hayashi; Tappei Takada; Hiroshi Suzuki; Hidetaka Akita; Yuichi Sugiyama
Two common PFIC2 mutations are associated with the impaired membrane trafficking of BSEP/ABCB11.
Hepatology (Baltimore, Md.) 2005;41(4):916-24.
2005: Tappei Takada; Hiroshi Suzuki; Yuichi Sugiyama
Characterization of polarized expression of point- or deletion-mutated human BCRP/ABCG2 in LLC-PK1 cells.
Pharmaceutical research 2005;22(3):458-64.
2005: Yasuhisa Adachi; Hiroshi Suzuki; Alfred H Schinkel; Yuichi Sugiyama
Role of breast cancer resistance protein (Bcrp1/Abcg2) in the extrusion of glucuronide and sulfate conjugates from enterocytes to intestinal lumen.
Molecular pharmacology 2005;67(3):923-8.
2005: Shuichi Hirono; Izumi Nakagome; Rie Imai; Kazuya Maeda; Hiroyuki Kusuhara; Yuichi Sugiyama
Estimation of the three-dimensional pharmacophore of ligands for rat multidrug-resistance-associated protein 2 using ligand-based drug design techniques.
Pharmaceutical research 2005;22(2):260-9.
2005: Hiroyuki Kusuhara; Yuichi Sugiyama
Active efflux across the blood-brain barrier: role of the solute carrier family.
NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics 2005;2(1):73-85.
2005: Young-Joo Lee; Hiroyuki Kusuhara; johan jonker; Alfred H Schinkel; Yuichi Sugiyama
Investigation of efflux transport of dehydroepiandrosterone sulfate and mitoxantrone at the mouse blood-brain barrier: a minor role of breast cancer resistance protein.
The Journal of pharmacology and experimental therapeutics 2005;312(1):44-52.
2005: Sachiko Mita; Hiroshi Suzuki; Hidetaka Akita; Bruno Stieger; Peter J Meier Abt; Alan F Hofmann; Yuichi Sugiyama
Vectorial transport of bile salts across MDCK cells expressing both rat Na+-taurocholate cotransporting polypeptide and rat bile salt export pump.
American journal of physiology. Gastrointestinal and liver physiology 2005;288(1):G159-67.
2004: Ryota Kikuchi; Hiroyuki Kusuhara; Takaaki Abe; Hitoshi Endou; Yuichi Sugiyama
Involvement of multiple transporters in the efflux of 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors across the blood-brain barrier.
The Journal of pharmacology and experimental therapeutics 2004;311(3):1147-53.
2004: Megumi Iwai; Hiroshi Suzuki; Ichiro Ieiri; Kenji Otsubo; Yuichi Sugiyama
Functional analysis of single nucleotide polymorphisms of hepatic organic anion transporter OATP1B1 (OATP-C).
Pharmacogenetics 2004;14(11):749-57.
2004: Yoshinori Nagata; Hiroyuki Kusuhara; Tomoki Imaoka; Hitoshi Endou; Yuichi Sugiyama
Involvement of rat organic anion transporter 3 in the uptake of an organic herbicide, 2,4-dichlorophenoxyacetate, by the isolated rat choroid plexus.
Journal of pharmaceutical sciences 2004;93(11):2724-32.
2004: Hiroyuki Kusuhara; Yuichi Sugiyama
Efflux transport systems for organic anions and cations at the blood-CSF barrier.
Advanced drug delivery reviews 2004;56(12):1741-63.
2004: Chihiro Kondo; Hiroshi Suzuki; Masaya Itoda; Shogo Ozawa; Jun-ichi Sawada; Daisuke Kobayashi; Ichiro Ieiri; Kazunori Mine; Kenji Ohtsubo; Yuichi Sugiyama
Functional analysis of SNPs variants of BCRP/ABCG2.
Pharmaceutical research 2004;21(10):1895-903.
2004: Masaru Hirano; Kazuya Maeda; Yoshihisa Shitara; Yuichi Sugiyama
Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans.
The Journal of pharmacology and experimental therapeutics 2004;311(1):139-46.
2004: Makoto Sasaki; Hiroshi Suzuki; Jun Aoki; Kousei Ito; Peter J Meier Abt; Yuichi Sugiyama
Prediction of in vivo biliary clearance from the in vitro transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II monolayer expressing both rat organic anion transporting polypeptide 4 and multidrug resistance associated protein 2.
Molecular pharmacology 2004;66(3):450-9.
2004: Yoshinori Nagata; Hiroyuki Kusuhara; Shuichi Hirono; Hitoshi Endou; Yuichi Sugiyama
Carrier-mediated uptake of H2-receptor antagonists by the rat choroid plexus: involvement of rat organic anion transporter 3.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(9):1040-7.
2004: Naomi Mizuno; Michiko Suzuki; Hiroyuki Kusuhara; Hiroshi Suzuki; Kenji Takeuchi; Takuro Niwa; johan jonker; Yuichi Sugiyama
Impaired renal excretion of 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl) benzothiazole (E3040) sulfate in breast cancer resistance protein (BCRP1/ABCG2) knockout mice.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(9):898-901.
2004: Kimio Tohyama; Hiroyuki Kusuhara; Yuichi Sugiyama
Involvement of multispecific organic anion transporter, Oatp14 (Slc21a14), in the transport of thyroxine across the blood-brain barrier.
Endocrinology 2004;145(9):4384-91.
2004: Tomoki Imaoka; Hiroyuki Kusuhara; Satomi Adachi-Akahane; Maki Hasegawa; Naomi Morita; Hitoshi Endou; Yuichi Sugiyama
The renal-specific transporter mediates facilitative transport of organic anions at the brush border membrane of mouse renal tubules.
Journal of the American Society of Nephrology : JASN 2004;15(8):2012-22.
2004: Masakazu Hirouchi; Hiroshi Suzuki; Masaya Itoda; Shogo Ozawa; Jun-ichi Sawada; Ichiro Ieiri; Kenji Ohtsubo; Yuichi Sugiyama
Characterization of the cellular localization, expression level, and function of SNP variants of MRP2/ABCC2.
Pharmaceutical research 2004;21(5):742-8.
2004: Yoshitane Nozaki; Hiroyuki Kusuhara; Hitoshi Endou; Yuichi Sugiyama
Quantitative evaluation of the drug-drug interactions between methotrexate and nonsteroidal anti-inflammatory drugs in the renal uptake process based on the contribution of organic anion transporters and reduced folate carrier.
The Journal of pharmacology and experimental therapeutics 2004;309(1):226-34.
2004: Tsuneo Deguchi; Hiroyuki Kusuhara; Akira Takadate; Hitoshi Endou; Masaki Otagiri; Yuichi Sugiyama
Characterization of uremic toxin transport by organic anion transporters in the kidney.
Kidney international 2004;65(1):162-74.
2004: Young-Joo Lee; Hiroyuki Kusuhara; Yuichi Sugiyama
Do multidrug resistance-associated protein-1 and -2 play any role in the elimination of estradiol-17 beta-glucuronide and 2,4-dinitrophenyl-S-glutathione across the blood-cerebrospinal fluid barrier?
Journal of pharmaceutical sciences 2004;93(1):99-107.
2003: Nobuhiro Nishiyama; Souichiro Okazaki; Horacio Cabral; Masaki Miyamoto; Yukio Kato; Yuichi Sugiyama; Kazuto Nishio; Yasuhiro Matsumura; Kazunori Kataoka
Novel cisplatin-incorporated polymeric micelles can eradicate solid tumors in mice.
Cancer research 2003;63(24):8977-83.
2003: Daisuke Sugiyama; Hiroyuki Kusuhara; Hirokazu Taniguchi; Shumpei Ishikawa; Yoshitane Nozaki; Hiroyuki Aburatani; Yuichi Sugiyama
Functional characterization of rat brain-specific organic anion transporter (Oatp14) at the blood-brain barrier: high affinity transporter for thyroxine.
The Journal of biological chemistry 2003;278(44):43489-95.
2003: Asako Hayashi; Hiroshi Suzuki; Ken Itoh; Masayuki Yamamoto; Yuichi Sugiyama
Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein 1 in mouse embryo fibroblasts.
Biochemical and biophysical research communications 2003;310(3):824-9.
2003: Daisuke Sugiyama; Hiroyuki Kusuhara; Yong-Joo Lee; Yuichi Sugiyama
Involvement of multidrug resistance associated protein 1 (Mrp1) in the efflux transport of 17beta estradiol-D-17beta-glucuronide (E217betaG) across the blood-brain barrier.
Pharmaceutical research 2003;20(9):1394-400.
2003: Naomi Mizuno; Takuro Niwa; Yoshihisa Yotsumoto; Yuichi Sugiyama
Impact of drug transporter studies on drug discovery and development.
Pharmacological reviews 2003;55(3):425-61.
2003: Yasuhisa Adachi; Hiroshi Suzuki; Yuichi Sugiyama
Quantitative evaluation of the function of small intestinal P-glycoprotein: comparative studies between in situ and in vitro.
Pharmaceutical research 2003;20(8):1163-9.
2003: Ryota Kikuchi; Hiroyuki Kusuhara; Daisuke Sugiyama; Yuichi Sugiyama
Contribution of organic anion transporter 3 (Slc22a8) to the elimination of p-aminohippuric acid and benzylpenicillin across the blood-brain barrier.
The Journal of pharmacology and experimental therapeutics 2003;306(1):51-8.
2003: Michiko Suzuki; Hiroshi Suzuki; Yoshikazu Sugimoto; Yuichi Sugiyama
ABCG2 transports sulfated conjugates of steroids and xenobiotics.
The Journal of biological chemistry 2003;278(25):22644-9.
2003: Maki Hasegawa; Hiroyuki Kusuhara; Hitoshi Endou; Yuichi Sugiyama
Contribution of organic anion transporters to the renal uptake of anionic compounds and nucleoside derivatives in rat.
The Journal of pharmacology and experimental therapeutics 2003;305(3):1087-97.
2003: Hiroyuki Kusuhara; Zhonggui He; Yoshinori Nagata; Yoshitane Nozaki; Takashi Ito; Hiroyuki Masuda; Peter J Meier Abt; Takaaki Abe; Yuichi Sugiyama
Expression and functional involvement of organic anion transporting polypeptide subtype 3 (Slc21a7) in rat choroid plexus.
Pharmaceutical research 2003;20(5):720-7.
2003: De-Sheng Wang; Hiroyuki Kusuhara; Yukio Kato; johan jonker; Alfred H Schinkel; Yuichi Sugiyama
Involvement of organic cation transporter 1 in the lactic acidosis caused by metformin.
Molecular pharmacology 2003;63(4):844-8.
2003: Nobuko Fukuma; Nobuyoshi Akimitsu; Hiroshi Hamamoto; Hiroyuki Kusuhara; Yuichi Sugiyama; Kazuhisa Sekimizu
A role of the Duffy antigen for the maintenance of plasma chemokine concentrations.
Biochemical and biophysical research communications 2003;303(1):137-9.
2003: Yoshihisa Shitara; Tomoo Itoh; Hitoshi Sato; Albert P Li; Yuichi Sugiyama
Inhibition of transporter-mediated hepatic uptake as a mechanism for drug-drug interaction between cerivastatin and cyclosporin A.
The Journal of pharmacology and experimental therapeutics 2003;304(2):610-6.
2003: Motohiro Kato; Koji Chiba; Akihiro Hisaka; Michi Ishigami; Makoto Kayama; Naomi Mizuno; Yoshinori Nagata; Susumu Takakuwa; Yuko Tsukamoto; Kaoru Ueda; Hiroyuki Kusuhara; Kiyomi Ito; Yuichi Sugiyama
The intestinal first-pass metabolism of substrates of CYP3A4 and P-glycoprotein-quantitative analysis based on information from the literature.
Drug metabolism and pharmacokinetics 2003;18(6):365-72.
2003: Motohiro Kato; Tatsuhiko Tachibana; Kiyomi Ito; Yuichi Sugiyama
Evaluation of methods for predicting drug-drug interactions by Monte Carlo simulation.
Drug metabolism and pharmacokinetics 2003;18(2):121-7.
2003: Yoshihisa Shitara; Albert P Li; Yukio Kato; Chuang Lu; Kiyomi Ito; Tomoo Itoh; Yuichi Sugiyama
Function of uptake transporters for taurocholate and estradiol 17beta-D-glucuronide in cryopreserved human hepatocytes.
Drug metabolism and pharmacokinetics 2003;18(1):33-41.
2003: Masato Horikawa; Yukio Kato; Charles A Tyson; Yuichi Sugiyama
Potential cholestatic activity of various therapeutic agents assessed by bile canalicular membrane vesicles isolated from rats and humans.
Drug metabolism and pharmacokinetics 2003;18(1):16-22.
2003: Hiroyuki Kusuhara; Tetsuya Terasaki; Yuichi Sugiyama
Brain efflux index method. Characterization of efflux transport across the blood-brain barrier.
Methods in molecular medicine 2003;89():219-31.
2002: Yukio Kato; Hiroshi Suzuki; Yuichi Sugiyama
Toxicological implications of hepatobiliary transporters.
Toxicology 2002;181-182():287-90.
2002: Hidetaka Akita; Hiroshi Suzuki; Yuichi Sugiyama
Sinusoidal efflux of taurocholate correlates with the hepatic expression level of Mrp3.
Biochemical and biophysical research communications 2002;299(5):681-7.
2002: Hiroshi Suzuki; Yuichi Sugiyama
Single nucleotide polymorphisms in multidrug resistance associated protein 2 (MRP2/ABCC2): its impact on drug disposition.
Advanced drug delivery reviews 2002;54(10):1311-31.
2002: Masato Horikawa; Yukio Kato; Yuichi Sugiyama
Reduced gastrointestinal toxicity following inhibition of the biliary excretion of irinotecan and its metabolites by probenecid in rats.
Pharmaceutical research 2002;19(9):1345-53.
2002: De-Sheng Wang; johan jonker; Yukio Kato; Hiroyuki Kusuhara; Alfred H Schinkel; Yuichi Sugiyama
Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin.
The Journal of pharmacology and experimental therapeutics 2002;302(2):510-5.
2002: Yukio Kato; Kiyoka Kuge; Hiroyuki Kusuhara; Peter J Meier Abt; Yuichi Sugiyama
Gender difference in the urinary excretion of organic anions in rats.
The Journal of pharmacology and experimental therapeutics 2002;302(2):483-9.
2002: Bin Ji; Kousei Ito; Hiroshi Suzuki; Yuichi Sugiyama; Toshiharu Horie
Multidrug resistance-associated protein2 (MRP2) plays an important role in the biliary excretion of glutathione conjugates of 4-hydroxynonenal.
Free radical biology & medicine 2002;33(3):370-8.
2002: Kazuya Maeda; Yukio Kato; Yuichi Sugiyama
pH-dependent receptor/ligand dissociation as a determining factor for intracellular sorting of ligands for epidermal growth factor receptors in rat hepatocytes.
Journal of controlled release : official journal of the Controlled Release Society 2002;82(1):71-82.
2002: Yasumasa Gotoh; Yukio Kato; Bruno Stieger; Peter J Meier Abt; Yuichi Sugiyama
Gender difference in the Oatp1-mediated tubular reabsorption of estradiol 17beta-D-glucuronide in rats.
American journal of physiology. Endocrinology and metabolism 2002;282(6):E1245-54.
2002: Yoshinori Nagata; Hiroyuki Kusuhara; Hitoshi Endou; Yuichi Sugiyama
Expression and functional characterization of rat organic anion transporter 3 (rOat3) in the choroid plexus.
Molecular pharmacology 2002;61(5):982-8.
2002: Atsuyuki Kakee; Hitomi Takanaga; Ken-ichi Hosoya; Yuichi Sugiyama; Tetsuya Terasaki
In vivo evidence for brain-to-blood efflux transport of valproic acid across the blood-brain barrier.
Microvascular research 2002;63(2):233-8.
2002: Maki Hasegawa; Hiroyuki Kusuhara; Daisuke Sugiyama; Kousei Ito; Shirou Ueda; Hitoshi Endou; Yuichi Sugiyama
Functional involvement of rat organic anion transporter 3 (rOat3; Slc22a8) in the renal uptake of organic anions.
The Journal of pharmacology and experimental therapeutics 2002;300(3):746-53.
2002: Makoto Sasaki; Hiroshi Suzuki; Kousei Ito; Takaaki Abe; Yuichi Sugiyama
Transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II cell monolayer expressing both human organic anion-transporting polypeptide (OATP2/SLC21A6) and Multidrug resistance-associated protein 2 (MRP2/ABCC2).
The Journal of biological chemistry 2002;277(8):6497-503.
2002: Yoshihisa Shitara; Daisuke Sugiyama; Hiroyuki Kusuhara; Yukio Kato; Takaaki Abe; Peter J Meier Abt; Tomoo Itoh; Yuichi Sugiyama
Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport.
Pharmaceutical research 2002;19(2):147-53.
2002: Daisuke Sugiyama; Hiroyuki Kusuhara; Yoshihisa Shitara; Takaaki Abe; Yuichi Sugiyama
Effect of 17 beta-estradiol-D-17 beta-glucuronide on the rat organic anion transporting polypeptide 2-mediated transport differs depending on substrates.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(2):220-3.
2002: Hiroyuki Kusuhara; Yuichi Sugiyama
Role of transporters in the tissue-selective distribution and elimination of drugs: transporters in the liver, small intestine, brain and kidney.
Journal of controlled release : official journal of the Controlled Release Society 2002;78(1-3):43-54.
2002: Masato Horikawa; Yukio Kato; Charles A Tyson; Yuichi Sugiyama
The potential for an interaction between MRP2 (ABCC2) and various therapeutic agents: probenecid as a candidate inhibitor of the biliary excretion of irinotecan metabolites.
Drug metabolism and pharmacokinetics 2002;17(1):23-33.
2002: Kiyomi Ito; Koji Chiba; Masato Horikawa; Michi Ishigami; Naomi Mizuno; Jun Aoki; Yasumasa Gotoh; Takafumi Iwatsubo; Shin-ichi Kanamitsu; Motohiro Kato; Iichiro Kawahara; Kayoko Niinuma; Akiko Nishino; Norihito Sato; Yuko Tsukamoto; Kaoru Ueda; Tomoo Itoh; Yuichi Sugiyama
Which concentration of the inhibitor should be used to predict in vivo drug interactions from in vitro data?
AAPS pharmSci 2002;4(4):E25.
2002: Hidetaka Akita; Hiroshi Suzuki; Tomoko Hirohashi; Hajime Takikawa; Yuichi Sugiyama
Transport activity of human MRP3 expressed in Sf9 cells: comparative studies with rat MRP3.
Pharmaceutical research 2002;19(1):34-41.
2001: Yasuhisa Adachi; Hiroshi Suzuki; Yuichi Sugiyama
Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein.
Pharmaceutical research 2001;18(12):1660-8.
2001: Yuji Yamamoto; Yukio Nagasaki; Yukio Kato; Yuichi Sugiyama; Kazunori Kataoka
Long-circulating poly(ethylene glycol)-poly(D,L-lactide) block copolymer micelles with modulated surface charge.
Journal of controlled release : official journal of the Controlled Release Society 2001;77(1-2):27-38.
2001: K Shirota; Yukio Kato; Kazutoshi Suzuki; Yuichi Sugiyama
Characterization of novel kidney-specific delivery system using an alkylglucoside vector.
The Journal of pharmacology and experimental therapeutics 2001;299(2):459-67.
2001: Atsuyuki Kakee; Hitomi Takanaga; Tetsuya Terasaki; M Naito; T Tsuruo; Yuichi Sugiyama
Efflux of a suppressive neurotransmitter, GABA, across the blood-brain barrier.
Journal of neurochemistry 2001;79(1):110-8.
2001: Kousei Ito; Hiroshi Suzuki; Yuichi Sugiyama
Single amino acid substitution of rat MRP2 results in acquired transport activity for taurocholate.
American journal of physiology. Gastrointestinal and liver physiology 2001;281(4):G1034-43.
2001: Naomi Morita; Hiroyuki Kusuhara; Takashi Sekine; Hitoshi Endou; Yuichi Sugiyama
Functional characterization of rat organic anion transporter 2 in LLC-PK1 cells.
The Journal of pharmacology and experimental therapeutics 2001;298(3):1179-84.
2001: N Mizuno; Yukio Kato; M Iwamoto; Akinori Urae; Toshiaki Amamoto; T Niwa; Yuichi Sugiyama
Kinetic analysis of the disposition of insulin-like growth factor 1 in healthy volunteers.
Pharmaceutical research 2001;18(8):1203-9.
2001: Hidetaka Akita; Hiroshi Suzuki; Yuichi Sugiyama
Sinusoidal efflux of taurocholate is enhanced in Mrp2-deficient rat liver.
Pharmaceutical research 2001;18(8):1119-25.
2001: Nobuhiro Nishiyama; Yukio Kato; Yuichi Sugiyama; Kazunori Kataoka
Cisplatin-loaded polymer-metal complex micelle with time-modulated decaying property as a novel drug delivery system.
Pharmaceutical research 2001;18(7):1035-41.
2001: Daisuke Sugiyama; Hiroyuki Kusuhara; Yoshihisa Shitara; Takaaki Abe; Peter J Meier Abt; Takashi Sekine; Hitoshi Endou; Hiroshi Suzuki; Yuichi Sugiyama
Characterization of the efflux transport of 17beta-estradiol-D-17beta-glucuronide from the brain across the blood-brain barrier.
The Journal of pharmacology and experimental therapeutics 2001;298(1):316-22.
2001: K Ueda; Yukio Kato; K Komatsu; Yuichi Sugiyama
Inhibition of biliary excretion of methotrexate by probenecid in rats: quantitative prediction of interaction from in vitro data.
The Journal of pharmacology and experimental therapeutics 2001;297(3):1036-43.
2001: Yong-Hee Han; Yukio Kato; M Haramura; M Ohta; H Matsuoka; Yuichi Sugiyama
Physicochemical parameters responsible for the affinity of methotrexate analogs for rat canalicular multispecific organic anion transporter (cMOAT/MRP2).
Pharmaceutical research 2001;18(5):579-86.
2001: Kousei Ito; Hiroshi Suzuki; Yuichi Sugiyama
Charged amino acids in the transmembrane domains are involved in the determination of the substrate specificity of rat Mrp2.
Molecular pharmacology 2001;59(5):1077-85.
2001: Yong-Hee Han; Yukio Kato; Yoshiteru Watanabe; K Terao; Y Asoh; Yuichi Sugiyama
Carrier-mediated hepatobiliary transport of a novel antifolate, N-[4-[(2,4-dianninopteridine-6-yl)methyl]-3,4-dihydro-2H-1,4-benzothiazin-7-yl]carbonyl-L-homoglutamic acid, in rats.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(4 Pt 1):394-400.
2001: Hidetaka Akita; Hiroshi Suzuki; Kousei Ito; S Kinoshita; N Sato; Hajime Takikawa; Yuichi Sugiyama
Characterization of bile acid transport mediated by multidrug resistance associated protein 2 and bile salt export pump.
Biochimica et biophysica acta 2001;1511(1):7-16.
2001: N Hirota; Kousei Ito; Takeshi Iwatsubo; Carol E Green; Charles A Tyson; N Shimada; Hiroshi Suzuki; Yuichi Sugiyama
In vitro/in vivo scaling of alprazolam metabolism by CYP3A4 and CYP3A5 in humans.
Biopharmaceutics & drug disposition 2001;22(2):53-71.
2001: K Shirota; Yukio Kato; Tatsuro Irimura; H Kondo; Yuichi Sugiyama
Anti-metastatic effect of the sialyl Lewis-X analog GSC-150 on the human colon carcinoma derived cell line KM12-HX in the mouse.
Biological & pharmaceutical bulletin 2001;24(3):316-9.
2000: Hiroshi Suzuki; Yuichi Sugiyama
Role of metabolic enzymes and efflux transporters in the absorption of drugs from the small intestine.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2000;12(1):3-12.
2000: I Kawahara; Yukio Kato; Hiroshi Suzuki; M Achira; Kousei Ito; C L Crespi; Yuichi Sugiyama
Selective inhibition of human cytochrome P450 3A4 by N-[2(R)-hydroxy-1(S)-indanyl]-5-[2(S)-(1, 1-dimethylethylaminocarbonyl)-4-[(furo[2, 3-b]pyridin-5-yl)methyl]piperazin-1-yl]-4(S)-hydroxy-2(R)-phenylmethy lpentanamide and P-glycoprotein by valspodar in gene transfectant systems.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(10):1238-43.
2000: Akie Nishino; Yukio Kato; Takashi Igarashi; Yuichi Sugiyama
Both cMOAT/MRP2 and another unknown transporter(s) are responsible for the biliary excretion of glucuronide conjugate of the nonpeptide angiotensin II antagonist, telmisaltan.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(10):1146-8.
2000: KX Liu; Yukio Kato; TI Kaku; T Santa; K Imai; A Yagi; T Ishizu; Yuichi Sugiyama
Hydroxyprolylserine derivatives JBP923 and JBP485 exhibit the antihepatitis activities after gastrointestinal absorption in rats.
The Journal of pharmacology and experimental therapeutics 2000;294(2):510-5.
2000: A Morikawa; Y Goto; Hiroshi Suzuki; Tomoko Hirohashi; Yuichi Sugiyama
Biliary excretion of 17beta-estradiol 17beta-D-glucuronide is predominantly mediated by cMOAT/MRP2.
Pharmaceutical research 2000;17(5):546-52.
2000: Tappei Takada; Hiroshi Suzuki; Yuichi Sugiyama
Characterization of 5'-flanking region of human MRP3.
Biochemical and biophysical research communications 2000;270(3):728-32.
2000: H Kouzuki; Hiroshi Suzuki; Yuichi Sugiyama
Pharmacokinetic study of the hepatobiliary transport of indomethacin.
Pharmaceutical research 2000;17(4):432-8.
2000: S i Kanamitsu; Kousei Ito; Carol E Green; Charles A Tyson; N Shimada; Yuichi Sugiyama
Prediction of in vivo interaction between triazolam and erythromycin based on in vitro studies using human liver microsomes and recombinant human CYP3A4.
Pharmaceutical research 2000;17(4):419-26.
2000: K Komatsu; Kousei Ito; Y Nakajima; S i Kanamitsu; S Imaoka; Y Funae; Carol E Green; Charles A Tyson; N Shimada; Yuichi Sugiyama
Prediction of in vivo drug-drug interactions between tolbutamide and various sulfonamides in humans based on in vitro experiments.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(4):475-81.
2000: S i Kanamitsu; Kousei Ito; H Okuda; K Ogura; T Watabe; K Muro; Yuichi Sugiyama
Prediction of in vivo drug-drug interactions based on mechanism-based inhibition from in vitro data: inhibition of 5-fluorouracil metabolism by (E)-5-(2-Bromovinyl)uracil.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(4):467-74.
2000: S i Kanamitsu; Kousei Ito; Yuichi Sugiyama
Quantitative prediction of in vivo drug-drug interactions from in vitro data based on physiological pharmacokinetics: use of maximum unbound concentration of inhibitor at the inlet to the liver.
Pharmaceutical research 2000;17(3):336-43.
2000: K Ogawa; Hiroshi Suzuki; Tomoko Hirohashi; T Ishikawa; Peter J Meier Abt; K Hirose; T Akizawa; M Yoshioka; Yuichi Sugiyama
Characterization of inducible nature of MRP3 in rat liver.
American journal of physiology. Gastrointestinal and liver physiology 2000;278(3):G438-46.
2000: H Kouzuki; Hiroshi Suzuki; Bruno Stieger; Peter J Meier Abt; Yuichi Sugiyama
Characterization of the transport properties of organic anion transporting polypeptide 1 (oatp1) and Na(+)/taurocholate cotransporting polypeptide (Ntcp): comparative studies on the inhibitory effect of their possible substrates in hepatocytes and cDNA-transfected COS-7 cells.
The Journal of pharmacology and experimental therapeutics 2000;292(2):505-11.
2000: Tomoko Hirohashi; Hiroshi Suzuki; Hajime Takikawa; Yuichi Sugiyama
ATP-dependent transport of bile salts by rat multidrug resistance-associated protein 3 (Mrp3).
The Journal of biological chemistry 2000;275(4):2905-10.
2000: Hiroshi Suzuki; Yuichi Sugiyama
Transport of drugs across the hepatic sinusoidal membrane: sinusoidal drug influx and efflux in the liver.
Seminars in liver disease 2000;20(3):251-63.
2000: Y Watanabe; Hiroshi Suzuki; Kazutoshi Suzuki; T Ando; S Nakabayashi; Yuichi Sugiyama
Detection of the membrane protein recognized by the kidney-specific alkylglucoside vector.
Pharmaceutical research 2000;17(1):49-54.
2000: Y Gotoh; Hiroshi Suzuki; S Kinoshita; Tomoko Hirohashi; Yukio Kato; Yuichi Sugiyama
Involvement of an organic anion transporter (canalicular multispecific organic anion transporter/multidrug resistance-associated protein 2) in gastrointestinal secretion of glutathione conjugates in rats.
The Journal of pharmacology and experimental therapeutics 2000;292(1):433-9.
2000: Tomoko Hirohashi; Hiroshi Suzuki; XY Chu; I Tamai; A Tsuji; Yuichi Sugiyama
Function and expression of multidrug resistance-associated protein family in human colon adenocarcinoma cells (Caco-2).
The Journal of pharmacology and experimental therapeutics 2000;292(1):265-70.
1999: Yong-Hee Han; Yukio Kato; Yuichi Sugiyama
Binding and transport of methotrexate and its derivative, MX-68, across the brush-border membrane in rat kidney.
Biopharmaceutics & drug disposition 1999;20(8):361-7.
1999: Yuichi Sugiyama; Hiroyuki Kusuhara; Hiroshi Suzuki
Kinetic and biochemical analysis of carrier-mediated efflux of drugs through the blood-brain and blood-cerebrospinal fluid barriers: importance in the drug delivery to the brain.
Journal of controlled release : official journal of the Controlled Release Society 1999;62(1-2):179-86.
1999: Yong-Hee Han; Yukio Kato; Yuichi Sugiyama
Nonlinear disposition kinetics of a novel antifolate, MX-68, in rats.
The Journal of pharmacology and experimental therapeutics 1999;291(1):204-12.
1999: H Ishizuka; K Konno; T Shiina; H Naganuma; K Nishimura; K Ito; Hiroshi Suzuki; Yuichi Sugiyama
Species differences in the transport activity for organic anions across the bile canalicular membrane.
The Journal of pharmacology and experimental therapeutics 1999;290(3):1324-30.
1999: S Akhteruzzaman; Yukio Kato; H Kouzuki; Hiroshi Suzuki; Akihiro Hisaka; Bruno Stieger; Peter J Meier Abt; Yuichi Sugiyama
Carrier-mediated hepatic uptake of peptidic endothelin antagonists in rats.
The Journal of pharmacology and experimental therapeutics 1999;290(3):1107-15.
1999: M Kato; Yukio Kato; Tetsuya Nakamura; Yuichi Sugiyama
Efficient extraction by the liver governs overall elimination of hepatocyte growth factor in rats.
The Journal of pharmacology and experimental therapeutics 1999;290(1):373-9.
1999: Jo Nishino; Hiroshi Suzuki; Daisuke Sugiyama; T Kitazawa; Kousei Ito; Manabu Hanano; Yuichi Sugiyama
Transepithelial transport of organic anions across the choroid plexus: possible involvement of organic anion transporter and multidrug resistance-associated protein.
The Journal of pharmacology and experimental therapeutics 1999;290(1):289-94.
1999: Taro Tokui; Daisuke Nakai; Rie Nakagomi; H Yawo; Takaaki Abe; Yuichi Sugiyama
Pravastatin, an HMG-CoA reductase inhibitor, is transported by rat organic anion transporting polypeptide, oatp2.
Pharmaceutical research 1999;16(6):904-8.
1999: S Song; Hiroshi Suzuki; R Kawai; Yuichi Sugiyama
Effect of PSC 833, a P-glycoprotein modulator, on the disposition of vincristine and digoxin in rats.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(6):689-94.
1999: Tomoko Hirohashi; Hiroshi Suzuki; Yuichi Sugiyama
Characterization of the transport properties of cloned rat multidrug resistance-associated protein 3 (MRP3).
The Journal of biological chemistry 1999;274(21):15181-5.
1999: Hiroyuki Kusuhara; Takashi Sekine; Naoko Utsunomiya-Tate; M Tsuda; R Kojima; S H Cha; Yuichi Sugiyama; Yoshiakira Kanai; Hitoshi Endou
Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain.
The Journal of biological chemistry 1999;274(19):13675-80.
1999: I Kino; Yukio Kato; J H Lin; Yuichi Sugiyama
Renal handling of biphosphonate alendronate in rats.
Biopharmaceutics & drug disposition 1999;20(4):193-8.
1999: K Niinuma; Yukio Kato; Hiroshi Suzuki; Charles A Tyson; V Weizer; Jack Dabbs; R Froehlich; Carol E Green; Yuichi Sugiyama
Primary active transport of organic anions on bile canalicular membrane in humans.
The American journal of physiology 1999;276(5 Pt 1):G1153-64.
1999: M Kato; Yukio Kato; Yuichi Sugiyama
Mechanism of the upregulation of erythropoietin-induced uptake clearance by the spleen.
The American journal of physiology 1999;276(5 Pt 1):E887-95.
1999: K Ueda; Hiroshi Suzuki; S Akiyama; Yuichi Sugiyama
Differences in substrate specificity among glutathione conjugates (GS-X) pump family members: comparison between multidrug resistance-associated protein and a novel transporter expressed on a cisplatin-resistant cell line (KCP-4).
Japanese journal of cancer research : Gann 1999;90(4):439-47.
1999: H Sasabe; Yukio Kato; Tetsuya Terasaki; A Tsuji; Yuichi Sugiyama
Differences in the hepatobiliary transport of two quinolone antibiotics, grepafloxacin and lomefloxacin, in the rat.
Biopharmaceutics & drug disposition 1999;20(3):151-8.
1999: XY Chu; Yukio Kato; Yuichi Sugiyama
Possible involvement of P-glycoprotein in biliary excretion of CPT-11 in rats.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(4):440-1.
1999: Yong-Hee Han; Yukio Kato; Hiroyuki Kusuhara; Hiroshi Suzuki; M Shimoda; E Kokue; Yuichi Sugiyama
Kinetic profile of overall elimination of 5-methyltetrahydropteroylglutamate in rats.
The American journal of physiology 1999;276(3 Pt 1):E580-7.
1999: Kousei Ito; Hiroyuki Kusuhara; Yuichi Sugiyama
Effects of intestinal CYP3A4 and P-glycoprotein on oral drug absorption--theoretical approach.
Pharmaceutical research 1999;16(2):225-31.
1999: XY Chu; Hiroshi Suzuki; K Ueda; Yukio Kato; S Akiyama; Yuichi Sugiyama
Active efflux of CPT-11 and its metabolites in human KB-derived cell lines.
The Journal of pharmacology and experimental therapeutics 1999;288(2):735-41.
1999: H Kouzuki; Hiroshi Suzuki; Kousei Ito; R Ohashi; Yuichi Sugiyama
Contribution of organic anion transporting polypeptide to uptake of its possible substrates into rat hepatocytes.
The Journal of pharmacology and experimental therapeutics 1999;288(2):627-34.
1999: S Akhteruzzaman; Yukio Kato; Akihiro Hisaka; Yuichi Sugiyama
Primary active transport of peptidic endothelin antagonists by rat hepatic canalicular membrane.
The Journal of pharmacology and experimental therapeutics 1999;288(2):575-81.
1999: Yukio Kato; S Akhteruzzaman; Akihiro Hisaka; Yuichi Sugiyama
Hepatobiliary transport governs overall elimination of peptidic endothelin antagonists in rats.
The Journal of pharmacology and experimental therapeutics 1999;288(2):568-74.
1999: M Achira; Hiroshi Suzuki; Kousei Ito; Yuichi Sugiyama
Comparative studies to determine the selective inhibitors for P-glycoprotein and cytochrome P4503A4.
AAPS pharmSci 1999;1(4):E18.
1999: Hiroshi Suzuki; Yuichi Sugiyama
Transporters for bile acids and organic anions.
Pharmaceutical biotechnology 1999;12():387-439.
1999: M Homma; Hiroshi Suzuki; Hiroyuki Kusuhara; M Naito; Takashi Tsuruo; Yuichi Sugiyama
High-affinity efflux transport system for glutathione conjugates on the luminal membrane of a mouse brain capillary endothelial cell line (MBEC4).
The Journal of pharmacology and experimental therapeutics 1999;288(1):198-203.
1998: S Kinoshita; Hiroshi Suzuki; Kousei Ito; Kazuhiko Kume; Takao Shimizu; Yuichi Sugiyama
Transfected rat cMOAT is functionally expressed on the apical membrane in Madin-Darby canine kidney (MDCK) cells.
Pharmaceutical research 1998;15(12):1851-6.
1998: S Song; Hiroshi Suzuki; Tetsuya Terasaki; M Lemaire; Yuichi Sugiyama
Modulation of the tumor disposition of vinca alkaloids by PSC 833 in vitro and in vivo.
The Journal of pharmacology and experimental therapeutics 1998;287(3):963-8.
1998: XY Chu; Yukio Kato; K Ueda; Hiroshi Suzuki; K Niinuma; Charles A Tyson; V Weizer; Jack Dabbs; R Froehlich; Carol E Green; Yuichi Sugiyama
Biliary excretion mechanism of CPT-11 and its metabolites in humans: involvement of primary active transporters.
Cancer research 1998;58(22):5137-43.
1998: KX Liu; Yukio Kato; I Kino; Tetsuya Nakamura; Yuichi Sugiyama
Ligand-induced downregulation of receptor-mediated clearance of hepatocyte growth factor in rats.
The American journal of physiology 1998;275(5 Pt 1):E835-42.
1998: S Song; Hiroshi Suzuki; R Kawai; C Tanaka; I Akasaka; Yuichi Sugiyama
Dose-dependent effects of PSC 833 on its tissue distribution and on the biliary excretion of endogenous substrates in rats.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(11):1128-33.
1998: Yoshihisa Shitara; Yukio Kato; Yuichi Sugiyama
Effect of brefeldin A and lysosomotropic reagents on intracellular trafficking of epidermal growth factor and transferrin in Madin-Darby canine kidney epithelial cells.
Journal of controlled release : official journal of the Controlled Release Society 1998;55(1):35-43.
1998: Yuichi Sugiyama; Kousei Ito
Future prospects for toxicokinetics: prediction of drug disposition and adverse effects in humans from in vitro measurements of drug metabolism, transport and binding.
The Journal of toxicological sciences 1998;23 Suppl 4():647-52.
1998: H Ishizuka; K Konno; H Naganuma; K Nishimura; H Kouzuki; Hiroshi Suzuki; Bruno Stieger; Peter J Meier Abt; Yuichi Sugiyama
Transport of temocaprilat into rat hepatocytes: role of organic anion transporting polypeptide.
The Journal of pharmacology and experimental therapeutics 1998;287(1):37-42.
1998: Hiroyuki Kusuhara; Yong-Hee Han; M Shimoda; E Kokue; Hiroshi Suzuki; Yuichi Sugiyama
Reduced folate derivatives are endogenous substrates for cMOAT in rats.
The American journal of physiology 1998;275(4 Pt 1):G789-96.
1998: Kousei Ito; Takeshi Iwatsubo; S i Kanamitsu; K Ueda; Hiroshi Suzuki; Yuichi Sugiyama
Prediction of pharmacokinetic alterations caused by drug-drug interactions: metabolic interaction in the liver.
Pharmacological reviews 1998;50(3):387-412.
1998: Hiroyuki Kusuhara; Hiroshi Suzuki; Yuichi Sugiyama
The role of P-glycoprotein and canalicular multispecific organic anion transporter in the hepatobiliary excretion of drugs.
Journal of pharmaceutical sciences 1998;87(9):1025-40.
1998: Y Kiuchi; Hiroshi Suzuki; Tomoko Hirohashi; Charles A Tyson; Yuichi Sugiyama
cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3).
FEBS letters 1998;433(1-2):149-52.
1998: T Yamada; Yukio Kato; Hiroyuki Kusuhara; M Lemaire; Yuichi Sugiyama
Characterization of the transport of a cationic octapeptide, octreotide, in rat bile canalicular membrane: possible involvement of P-glycoprotein.
Biological & pharmaceutical bulletin 1998;21(8):874-8.
1998: H Kouzuki; Hiroshi Suzuki; Kousei Ito; R Ohashi; Yuichi Sugiyama
Contribution of sodium taurocholate co-transporting polypeptide to the uptake of its possible substrates into rat hepatocytes.
The Journal of pharmacology and experimental therapeutics 1998;286(2):1043-50.
1998: T Kitazawa; Tetsuya Terasaki; Hiroshi Suzuki; Atsuyuki Kakee; Yuichi Sugiyama
Efflux of taurocholic acid across the blood-brain barrier: interaction with cyclic peptides.
The Journal of pharmacology and experimental therapeutics 1998;286(2):890-5.
1998: Hiroyuki Kusuhara; Hiroshi Suzuki; M Naito; Takashi Tsuruo; Yuichi Sugiyama
Characterization of efflux transport of organic anions in a mouse brain capillary endothelial cell line.
The Journal of pharmacology and experimental therapeutics 1998;285(3):1260-5.
1998: N Mizuno; Yukio Kato; K Shirota; Y Izumi; T Irimura; H Harashima; H Kiwada; Naomi Motoji; A Shigematsu; Yuichi Sugiyama
Mechanism of initial distribution of blood-borne colon carcinoma cells in the liver.
Journal of hepatology 1998;28(5):878-85.
1998: N Mizuno; Yukio Kato; Y Izumi; T Irimura; Yuichi Sugiyama
Importance of hepatic first-pass removal in metastasis of colon carcinoma cells.
Journal of hepatology 1998;28(5):865-77.
1998: H Sasabe; A Tsuji; Yuichi Sugiyama
Carrier-mediated mechanism for the biliary excretion of the quinolone antibiotic grepafloxacin and its glucuronide in rats.
The Journal of pharmacology and experimental therapeutics 1998;284(3):1033-9.
1998: H Imawaka; Yuichi Sugiyama
Kinetic study of the hepatobiliary transport of a new prostaglandin receptor agonist.
The Journal of pharmacology and experimental therapeutics 1998;284(3):949-57.
1998: H Sasabe; Yukio Kato; A Tsuji; Yuichi Sugiyama
Stereoselective hepatobiliary transport of the quinolone antibiotic grepafloxacin and its glucuronide in the rat.
The Journal of pharmacology and experimental therapeutics 1998;284(2):661-8.
1998: Kousei Ito; Hiroshi Suzuki; Tomoko Hirohashi; Kazuhiko Kume; Takao Shimizu; Yuichi Sugiyama
Functional analysis of a canalicular multispecific organic anion transporter cloned from rat liver.
The Journal of biological chemistry 1998;273(3):1684-8.
1998: Hiroshi Suzuki; Yuichi Sugiyama
Excretion of GSSG and glutathione conjugates mediated by MRP1 and cMOAT/MRP2.
Seminars in liver disease 1998;18(4):359-76.
1998: Yuichi Sugiyama; Yukio Kato; X Chu
Multiplicity of biliary excretion mechanisms for the camptothecin derivative irinotecan (CPT-11), its metabolite SN-38, and its glucuronide: role of canalicular multispecific organic anion transporter and P-glycoprotein.
Cancer chemotherapy and pharmacology 1998;42 Suppl():S44-9.
1998: Kousei Ito; Takeshi Iwatsubo; S i Kanamitsu; Y Nakajima; Yuichi Sugiyama
Quantitative prediction of in vivo drug clearance and drug interactions from in vitro data on metabolism, together with binding and transport.
Annual review of pharmacology and toxicology 1998;38():461-99.
1998: KX Liu; Yukio Kato; TI Kaku; Yuichi Sugiyama
Human placental extract stimulates liver regeneration in rats.
Biological & pharmaceutical bulletin 1998;21(1):44-9.
1998: KX Liu; Yukio Kato; TI Kaku; Kunio Matsumoto; Tetsuya Nakamura; Yuichi Sugiyama
Protamine enhances the proliferative activity of hepatocyte growth factor in rats.
The American journal of physiology 1998;274(1 Pt 1):G21-8.
1997: KX Liu; Yukio Kato; M Kato; TI Kaku; Tetsuya Nakamura; Yuichi Sugiyama
Existence of two nonlinear elimination mechanisms for hepatocyte growth factor in rats.
The American journal of physiology 1997;273(5 Pt 1):E891-7.
1997: Hiroyuki Kusuhara; Hiroshi Suzuki; Tetsuya Terasaki; Atsuyuki Kakee; M Lemaire; Yuichi Sugiyama
P-Glycoprotein mediates the efflux of quinidine across the blood-brain barrier.
The Journal of pharmacology and experimental therapeutics 1997;283(2):574-80.
1997: Y Mano; Hiroshi Suzuki; Tetsuya Terasaki; T Iwahashi; K Ono; M Naito; Takashi Tsuruo; Yuichi Sugiyama
Kinetic analysis of the disposition of MRK16, an anti-P-glycoprotein monoclonal antibody, in tumors: comparison between in vitro and in vivo disposition.
The Journal of pharmacology and experimental therapeutics 1997;283(1):391-401.
1997: T Ooie; Tetsuya Terasaki; Hiroshi Suzuki; Yuichi Sugiyama
Kinetic evidence for active efflux transport across the blood-brain barrier of quinolone antibiotics.
The Journal of pharmacology and experimental therapeutics 1997;283(1):293-304.
1997: K Takasawa; Hiroshi Suzuki; Yuichi Sugiyama
Transport properties of 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine in the rat choroid plexus.
Biopharmaceutics & drug disposition 1997;18(7):611-22.
1997: Hiroshi Suzuki; Yuichi Sugiyama
[Primary active transporter responsible for the biliary excretion of xenobiotics].
Seikagaku. The Journal of Japanese Biochemical Society 1997;69(9):1098-101.
1997: A Kozu; Yukio Kato; Yoshihisa Shitara; Manabu Hanano; Yuichi Sugiyama
Kinetic analysis of transcytosis of epidermal growth factor in Madin-Darby canine kidney epithelial cells.
Pharmaceutical research 1997;14(9):1228-35.
1997: K Takasawa; Tetsuya Terasaki; Hiroshi Suzuki; T Ooie; Yuichi Sugiyama
Distributed model analysis of 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine distribution in brain tissue and cerebrospinal fluid.
The Journal of pharmacology and experimental therapeutics 1997;282(3):1509-17.
1997: K Niinuma; O Takenaka; T Horie; K Kobayashi; Yukio Kato; Hiroshi Suzuki; Yuichi Sugiyama
Kinetic analysis of the primary active transport of conjugated metabolites across the bile canalicular membrane: comparative study of S-(2,4-dinitrophenyl)-glutathione and 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)benzothiazole glucuronide.
The Journal of pharmacology and experimental therapeutics 1997;282(2):866-72.
1997: T Ooie; Tetsuya Terasaki; Hiroshi Suzuki; Yuichi Sugiyama
Quantitative brain microdialysis study on the mechanism of quinolones distribution in the central nervous system.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(7):784-9.
1997: H Sasabe; Tetsuya Terasaki; A Tsuji; Yuichi Sugiyama
Carrier-mediated hepatic uptake of quinolone antibiotics in the rat.
The Journal of pharmacology and experimental therapeutics 1997;282(1):162-71.
1997: Hiroshi Suzuki; Yuichi Sugiyama
[Role of transporters in the detoxification of xenobiotics: recent advances in the study of cMOAT/MRP].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1997;42(8):1273-84.
1997: XY Chu; Yukio Kato; Yuichi Sugiyama
Multiplicity of biliary excretion mechanisms for irinotecan, CPT-11, and its metabolites in rats.
Cancer research 1997;57(10):1934-8.
1997: H C Shin; Yukio Kato; T Yamada; K Niinuma; Akihiro Hisaka; Yuichi Sugiyama
Hepatobiliary transport mechanism for the cyclopentapeptide endothelin antagonist BQ-123.
The American journal of physiology 1997;272(5 Pt 1):G979-86.
1997: T Izumi; S Enomoto; K Hoshiyama; K Sasahara; Yuichi Sugiyama
Pharmacokinetic stereoselectivity of troglitazone, an antidiabetic agent, in the KK mouse.
Biopharmaceutics & drug disposition 1997;18(4):305-24.
1997: H Kusuhara; H Suzuki; Yuichi Sugiyama
[The role of P-glycoprotein in the liver].
Nihon rinsho. Japanese journal of clinical medicine 1997;55(5):1069-76.
1997: T Yamada; K Niinuma; M Lemaire; Tetsuya Terasaki; Yuichi Sugiyama
Carrier-mediated hepatic uptake of the cationic cyclopeptide, octreotide, in rats. Comparison between in vivo and in vitro.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(5):536-43.
1997: T Izumi; K Hoshiyama; S Enomoto; K Sasahara; Yuichi Sugiyama
Determination of protein binding of troglitazone stereoisomers by fluorometric titration.
Biopharmaceutics & drug disposition 1997;18(3):241-57.
1997: K Takasawa; Tetsuya Terasaki; Hiroshi Suzuki; Yuichi Sugiyama
In vivo evidence for carrier-mediated efflux transport of 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine across the blood-brain barrier via a probenecid-sensitive transport system.
The Journal of pharmacology and experimental therapeutics 1997;281(1):369-75.
1997: XY Chu; Yukio Kato; K Niinuma; K I Sudo; H Hakusui; Yuichi Sugiyama
Multispecific organic anion transporter is responsible for the biliary excretion of the camptothecin derivative irinotecan and its metabolites in rats.
The Journal of pharmacology and experimental therapeutics 1997;281(1):304-14.
1997: T Izumi; K Hosiyama; S Enomoto; K Sasahara; Yuichi Sugiyama
Pharmacokinetics of troglitazone, an antidiabetic agent: prediction of in vivo stereoselective sulfation and glucuronidation from in vitro data.
The Journal of pharmacology and experimental therapeutics 1997;280(3):1392-400.
1997: H Ishizuka; K Konno; H Naganuma; K Sasahara; Y Kawahara; K Niinuma; Hiroshi Suzuki; Yuichi Sugiyama
Temocaprilat, a novel angiotensin-converting enzyme inhibitor, is excreted in bile via an ATP-dependent active transporter (cMOAT) that is deficient in Eisai hyperbilirubinemic mutant rats (EHBR).
The Journal of pharmacology and experimental therapeutics 1997;280(3):1304-11.
1997: T Hamada; Yukio Kato; T Terasaki; Yuichi Sugiyama
Cell density-dependent mitogenic effect and -independent cellular handling of epidermal growth factor in primary cultured rat hepatocytes.
Journal of hepatology 1997;26(2):353-60.
1997: Tomoko Hirohashi; Tetsuya Terasaki; M Shigetoshi; Yuichi Sugiyama
In vivo and in vitro evidence for nonrestricted transport of 2',7'-bis(2-carboxyethyl)-5(6)-carboxyfluorescein tetraacetoxymethyl ester at the blood-brain barrier.
The Journal of pharmacology and experimental therapeutics 1997;280(2):813-9.
1997: Kousei Ito; Hiroshi Suzuki; Tomoko Hirohashi; Kazuhiko Kume; Takao Shimizu; Yuichi Sugiyama
Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR.
The American journal of physiology 1997;272(1 Pt 1):G16-22.
1996: Yuichi Sugiyama; K Ito; M Tsuda; I Horii
Future prospects for toxicokinetics: its ability to predict drug adverse events in humans.
The Journal of toxicological sciences 1996;21(5):511-6.
1996: Yuichi Sugiyama; Takeshi Iwatsubo; K Ueda; K Ito
Strategic proposals for avoiding toxic interactions with drugs for clinical use during development and after marketing of a new drug: pharmacokinetic consideration.
The Journal of toxicological sciences 1996;21(5):309-16.
1996: M Yamazaki; Taro Tokui; M Ishigami; Yuichi Sugiyama
Tissue-selective uptake of pravastatin in rats: contribution of a specific carrier-mediated uptake system.
Biopharmaceutics & drug disposition 1996;17(9):775-89.
1996: T Yamada; K Niinuma; M Lemaire; Tetsuya Terasaki; Yuichi Sugiyama
Mechanism of the tissue distribution and biliary excretion of the cyclic peptide octreotide.
The Journal of pharmacology and experimental therapeutics 1996;279(3):1357-64.
1996: M Yamazaki; K Kobayashi; Yuichi Sugiyama
Primary active transport of pravastatin across the liver canalicular membrane in normal and mutant Eisai hyperbilirubinaemic rats.
Biopharmaceutics & drug disposition 1996;17(8):645-59.
1996: M Yamazaki; K Kobayashi; Yuichi Sugiyama
Primary active transport of pravastatin across the liver canalicular membrane in normal and mutant Eisai hyperbilirubinemic rats.
Biopharmaceutics & drug disposition 1996;17(7):607-21.
1996: D Nakai; T Seita; Tetsuya Terasaki; S Iwasa; Y Shoji; Y Mizushima; Yuichi Sugiyama
Cellular uptake mechanism for oligonucleotides: involvement of endocytosis in the uptake of phosphodiester oligonucleotides by a human colorectal adenocarcinoma cell line, HCT-15.
The Journal of pharmacology and experimental therapeutics 1996;278(3):1362-72.
1996: H C Shin; Yukio Kato; Yoshihisa Shitara; T Yamada; T Nakamura; Akihiro Hisaka; Yuichi Sugiyama
The endothelin receptor is a major determinant for the nonlinear tissue distribution of the endothelin antagonist BQ-123.
The Journal of pharmacology and experimental therapeutics 1996;278(2):607-13.
1996: T Ooie; H Suzuki; Tetsuya Terasaki; Yuichi Sugiyama
Comparative distribution of quinolone antibiotics in cerebrospinal fluid and brain in rats and dogs.
The Journal of pharmacology and experimental therapeutics 1996;278(2):590-6.
1996: T Ooie; H Suzuki; Tetsuya Terasaki; Yuichi Sugiyama
Kinetics of quinolone antibiotics in rats: efflux from cerebrospinal fluid to the circulation.
Pharmaceutical research 1996;13(7):1065-8.
1996: T Izumi; S Enomoto; K Hosiyama; K Sasahara; A Shibukawa; T Nakagawa; Yuichi Sugiyama
Prediction of the human pharmacokinetics of troglitazone, a new and extensively metabolized antidiabetic agent, after oral administration, with an animal scale-up approach.
The Journal of pharmacology and experimental therapeutics 1996;277(3):1630-41.
1996: Takeshi Iwatsubo; N Hirota; T Ooie; H Suzuki; Yuichi Sugiyama
Prediction of in vivo drug disposition from in vitro data based on physiological pharmacokinetics.
Biopharmaceutics & drug disposition 1996;17(4):273-310.
1996: T Ooie; H Suzuki; Tetsuya Terasaki; Yuichi Sugiyama
Characterization of the transport properties of a quinolone antibiotic, fleroxacin, in rat choroid plexus.
Pharmaceutical research 1996;13(4):523-7.
1996: K Niinuma; H Suzuki; M Yamazaki; Yuichi Sugiyama
[Preparation of plasma membrane and the analysis of transport kinetics and driving forces].
Nihon rinsho. Japanese journal of clinical medicine 1996;54(3):692-703.
1995: H Suzuki; Takeshi Iwatsubo; Yuichi Sugiyama
Applications and prospects for physiologically based pharmacokinetic (PB-PK) models involving pharmaceutical agents.
Toxicology letters 1995;82-83():349-55.
1995: M Ishigami; Taro Tokui; T Komai; K Tsukahara; M Yamazaki; Yuichi Sugiyama
Evaluation of the uptake of pravastatin by perfused rat liver and primary cultured rat hepatocytes.
Pharmaceutical research 1995;12(11):1741-5.
1995: KX Liu; Yukio Kato; Tetsuya Terasaki; S Aoki; K Okumura; T Nakamura; Yuichi Sugiyama
Contribution of parenchymal and non-parenchymal liver cells to the clearance of hepatocyte growth factor from the circulation in rats.
Pharmaceutical research 1995;12(11):1737-40.
1995: KX Liu; Yukio Kato; Tetsuya Terasaki; T Nakamura; Yuichi Sugiyama
Change in hepatic handling of hepatocyte growth factor during liver regeneration in rats.
The American journal of physiology 1995;269(5 Pt 1):G745-53.
1995: T Watanabe; H Suzuki; Yasufumi Sawada; M Naito; Takashi Tsuruo; M Inaba; Manabu Hanano; Yuichi Sugiyama
Induction of hepatic P-glycoprotein enhances biliary excretion of vincristine in rats.
Journal of hepatology 1995;23(4):440-8.
1994: Yukio Kato; KX Liu; T Nakamura; Yuichi Sugiyama
Heparin-hepatocyte growth factor complex with low plasma clearance and retained hepatocyte proliferating activity.
Hepatology (Baltimore, Md.) 1994;20(2):417-24.
1994: M Ogawa; H Suzuki; Yasufumi Sawada; Manabu Hanano; Yuichi Sugiyama
Kinetics of active efflux via choroid plexus of beta-lactam antibiotics from the CSF into the circulation.
The American journal of physiology 1994;266(2 Pt 2):R392-9.
1994: M Ichikawa; Yukio Kato; S Miyauchi; Yasufumi Sawada; Tatsuji Iga; T Fuwa; Manabu Hanano; Yuichi Sugiyama
Effect of perfusate pH on the influx of 5-5'-dimethyl-oxazolidine-2,4-dione and dissociation of epidermal growth factor from the cell-surface receptor: the existence of the proton diffusion barrier in the Disse space.
Journal of hepatology 1994;20(2):190-200.
1994: K Sathirakul; H Suzuki; T Yamada; Manabu Hanano; Yuichi Sugiyama
Multiple transport systems for organic anions across the bile canalicular membrane.
The Journal of pharmacology and experimental therapeutics 1994;268(1):65-73.
1994: K Ito; Yasufumi Sawada; Yuichi Sugiyama; H Suzuki; Manabu Hanano; Tatsuji Iga
Linear relationship between GABAA receptor occupancy of muscimol and glucose metabolic response in the conscious mouse brain. Clinical implication based on comparison with benzodiazepine receptor agonist.
Drug metabolism and disposition: the biological fate of chemicals 1994;22(1):50-4.
1993: K Sathirakul; H Suzuki; K Yasuda; Manabu Hanano; O Tagaya; T Horie; Yuichi Sugiyama
Kinetic analysis of hepatobiliary transport of organic anions in Eisai hyperbilirubinemic mutant rats.
The Journal of pharmacology and experimental therapeutics 1993;265(3):1301-12.
1993: KX Liu; Yukio Kato; M Yamazaki; O Higuchi; T Nakamura; Yuichi Sugiyama
Decrease in the hepatic clearance of hepatocyte growth factor in carbon tetrachloride-intoxicated rats.
Hepatology (Baltimore, Md.) 1993;17(4):651-60.
1993: M Yamazaki; H Suzuki; Manabu Hanano; Yuichi Sugiyama
Different relationships between cellular ATP and hepatic uptake among taurocholate, cholate, and organic anions.
The American journal of physiology 1993;264(4 Pt 1):G693-701.
1993: K Sathirakul; H Suzuki; K Yasuda; Manabu Hanano; Yuichi Sugiyama
Construction of a physiologically based pharmacokinetic model to describe the hepatobiliary excretion process of ligands: quantitative estimation of intracellular diffusion.
Biological & pharmaceutical bulletin 1993;16(3):273-9.
1993: M Yamazaki; H Suzuki; Manabu Hanano; Taro Tokui; T Komai; Yuichi Sugiyama
Na(+)-independent multispecific anion transporter mediates active transport of pravastatin into rat liver.
The American journal of physiology 1993;264(1 Pt 1):G36-44.
1992: H K Wang; S Miyachi; M Yamazaki; Yasufumi Sawada; Y B Chung; Tatsuji Iga; Manabu Hanano; Yuichi Sugiyama
Nonlinear pharmacokinetics of hepatobiliary transport of rose bengal in rats after i.v. bolus administration with varying doses.
Biopharmaceutics & drug disposition 1992;13(9):647-62.
1992: Hideyoshi Harashima; M Mamiya; M Yamazaki; Yasufumi Sawada; Tatsuji Iga; Manabu Hanano; Yuichi Sugiyama
Kinetic modeling of ouabain tissue distribution based on slow and saturable binding to Na,K-ATPase.
Pharmaceutical research 1992;9(12):1607-11.
1992: D C Kim; Manabu Hanano; Y Kanai; N Ohnuma; Yuichi Sugiyama
Localization of binding sites for epidermal growth factor (EGF) in rat kidney: evidence for the existence of low affinity EGF binding sites on the brush border membrane.
Pharmaceutical research 1992;9(11):1394-401.
1992: KX Liu; Yukio Kato; M Narukawa; D C Kim; Manabu Hanano; O Higuchi; T Nakamura; Yuichi Sugiyama
Importance of the liver in plasma clearance of hepatocyte growth factors in rats.
The American journal of physiology 1992;263(5 Pt 1):G642-9.
1992: Y Kato; H Sato; M Ichikawa; H Suzuki; Y Sawada; Manabu Hanano; T Fuwa; Yuichi Sugiyama
Existence of two pathways for the endocytosis of epidermal growth factor by rat liver: phenylarsine oxide-sensitive and -insensitive pathways.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(18):8507-11.
1992: M Ichikawa; S C Tsao; T H Lin; S Miyauchi; Yasufumi Sawada; Tatsuji Iga; Manabu Hanano; Yuichi Sugiyama
'Albumin-mediated transport phenomenon' observed for ligands with high membrane permeability. Effect of the unstirred water layer in the Disse's space of rat liver.
Journal of hepatology 1992;16(1-2):38-49.
1992: T Watanabe; S Miyauchi; Yasufumi Sawada; Tatsuji Iga; Manabu Hanano; M Inaba; Yuichi Sugiyama
Kinetic analysis of hepatobiliary transport of vincristine in perfused rat liver. Possible roles of P-glycoprotein in biliary excretion of vincristine.
Journal of hepatology 1992;16(1-2):77-88.
1992: Hideyoshi Harashima; M Mamiya; M Yamazaki; Yuichi Sugiyama; Yasufumi Sawada; Tatsuji Iga; Manabu Hanano
Significance of binding to Na,K-ATPase in the tissue distribution of ouabain in guinea pigs.
Pharmaceutical research 1992;9(4):474-9.
1992: H Matsushita; H Suzuki; Yuichi Sugiyama; Yasufumi Sawada; Tatsuji Iga; Y Kawaguchi; Manabu Hanano
Effect of benzylpenicillin on the disposition of cefodizime in rats: no net effect on total clearance due to decreased hepatobiliary clearance and increased renal clearance.
The Journal of pharmacology and experimental therapeutics 1992;260(2):499-504.
1992: D C Kim; Yuichi Sugiyama; Yasufumi Sawada; Manabu Hanano
Renal tubular handling of p-aminohippurate and epidermal growth factor (EGF) in filtering and nonfiltering perfused rat kidneys.
Pharmaceutical research 1992;9(2):271-5.
1992: M Yamazaki; Yuichi Sugiyama; H Suzuki; Tatsuji Iga; Manabu Hanano
Utilization of ATP-depleted cells in the analysis of taurocholate uptake by isolated rat hepatocytes.
Journal of hepatology 1992;14(1):54-63.
1992: M Yamazaki; H Suzuki; Yuichi Sugiyama; Tatsuji Iga; Manabu Hanano
Uptake of organic anions by isolated rat hepatocytes. A classification in terms of ATP-dependency.
Journal of hepatology 1992;14(1):41-7.
1992: D C Kim; Yuichi Sugiyama; Y Kanai; N Ohnuma; Manabu Hanano
Localization of epidermal growth factor (EGF) binding sites on antiluminal plasma membrane of rat kidney: autoradiographic study using nonfiltering perfused rat kidney.
Pharmaceutical research 1992;9(1):40-4.
1991: D C Kim; Manabu Hanano; Yasufumi Sawada; Tatsuji Iga; Yuichi Sugiyama
Kinetic analysis of clearance of epidermal growth factor in isolated perfused rat kidney.
The American journal of physiology 1991;261(6 Pt 2):F988-97.
1991: H Matsushita; H Suzuki; Yuichi Sugiyama; Yasufumi Sawada; Tatsuji Iga; Y Kawaguchi; Manabu Hanano
Facilitated transport of cefodizime into the rat central nervous system.
The Journal of pharmacology and experimental therapeutics 1991;259(2):620-5.
1991: S Yanai; Yuichi Sugiyama; Tatsuji Iga; T Fuwa; Manabu Hanano
Comparison of the methods for determining cell-surface and intracellular receptors for epidermal growth factor in the rat liver.
Pharmaceutical research 1991;8(5):557-62.
1991: S Yanai; Yuichi Sugiyama; D C Kim; Tatsuji Iga; T Fuwa; Manabu Hanano
Kinetic analysis of receptor-mediated endocytosis of epidermal growth factor by isolated rat hepatocytes.
The American journal of physiology 1991;260(3 Pt 1):C457-67.
1990: H Matsushita; H Suzuki; Yuichi Sugiyama; Yasufumi Sawada; Tatsuji Iga; Manabu Hanano; Y Kawaguchi
Prediction of the pharmacokinetics of cefodizime and cefotetan in humans from pharmacokinetic parameters in animals.
Journal of pharmacobio-dynamics 1990;13(10):602-11.
1990: Y B Chung; S Miyauchi; Yuichi Sugiyama; Hideyoshi Harashima; Tatsuji Iga; Manabu Hanano
Effect of various organic anions on the plasma disappearance of 1-anilino-8-naphthalene sulfonate.
Journal of hepatology 1990;11(2):240-51.
1990: Y B Chung; S Miyauchi; Yuichi Sugiyama; Hideyoshi Harashima; Tatsuji Iga; Manabu Hanano
Kinetic analysis of the dose-dependent hepatic handling of 1-anilino-8-naphthalene sulfonate in rats.
Journal of pharmacokinetics and biopharmaceutics 1990;18(4):313-33.
1990: H Sato; Yuichi Sugiyama; Yasufumi Sawada; Tatsuji Iga; T Fuwa; Manabu Hanano
Internalization of EGF in perfused rat liver is independent of the degree of receptor occupancy.
The American journal of physiology 1990;258(5 Pt 1):G682-9.
1990: Yuichi Sugiyama; H Takikawa
[Transport proteins for drugs and bile acids in the liver cytosol and plasma membrane--its multiplicity and functions].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1990;35(6):941-56.
1990: S Yanai; Yuichi Sugiyama; Tatsuji Iga; T Fuwa; Manabu Hanano
Kinetic analysis of the downregulation of epidermal growth factor receptors in rats in vivo.
The American journal of physiology 1990;258(4 Pt 1):C593-8.
1990: K Ito; Y Sawada; H Ishizuka; Yuichi Sugiyama; H Suzuki; T Iga; M Hanano
Measurement of cerebral glucose utilization from brain uptake of [14C]2-deoxyglucose and [3H]3-O-methylglucose in the mouse.
Journal of pharmacological methods 1990;23(2):129-40.
1990: Yuichi Sugiyama
[Kinetic analysis of hepatic transport of bioactive polypeptides based on receptor-mediated endocytosis: EGF as a model polypeptide].
Seikagaku. The Journal of Japanese Biochemical Society 1990;62(3):184-92.
1989: H Ishizuka; Yasufumi Sawada; K Ito; Yuichi Sugiyama; H Suzuki; Tatsuji Iga; Manabu Hanano
Nonlinear relationship between benzodiazepine receptor occupancy and glucose metabolic response in the conscious mouse brain in vivo.
The Journal of pharmacology and experimental therapeutics 1989;251(1):362-7.
1989: H Suzuki; Yasufumi Sawada; Yuichi Sugiyama; Tatsuji Iga; Manabu Hanano; R Spector
Transport of imipenem, a novel carbapenem antibiotic, in the rat central nervous system.
The Journal of pharmacology and experimental therapeutics 1989;250(3):979-84.
1989: H Sato; Yuichi Sugiyama; D C Kim; S Yanai; M Kurita; T Fuwa; Tatsuji Iga; Manabu Hanano
Decrease in the number of receptors for epidermal growth factor in the liver of D-galactosamine-intoxicated rats.
Biochemical pharmacology 1989;38(16):2663-71.
1989: T Nohjoh; H Suzuki; Yasufumi Sawada; Yuichi Sugiyama; Tatsuji Iga; Manabu Hanano
Transport of cefodizime, a novel third generation cephalosporin antibiotic, in isolated rat choroid plexus.
The Journal of pharmacology and experimental therapeutics 1989;250(1):324-8.
1989: Takeshi Iwatsubo; M Yamazaki; Yuichi Sugiyama; H Suzuki; S Yanai; D C Kim; H Satoh; Y Miyamoto; Tatsuji Iga; Manabu Hanano
Epidermal growth factor as a regulatory hormone maintaining a low pH microclimate in the rat small intestine.
Journal of pharmaceutical sciences 1989;78(6):457-9.
1989: N Okudaira; Yasufumi Sawada; Yuichi Sugiyama; Tatsuji Iga; Manabu Hanano
Effect of procainamide on renal tubular transport of cimetidine in the isolated perfused rat kidney.
Biochimica et biophysica acta 1989;981(1):1-7.
1989: H Suzuki; Yasufumi Sawada; Yuichi Sugiyama; Tatsuji Iga; Manabu Hanano
Facilitated transport of benzylpenicillin through the blood-brain barrier in rats.
Journal of pharmacobio-dynamics 1989;12(3):182-5.
1989: Konstanty Wierzba; Yuichi Sugiyama; K Okudaira; Tatsuji Iga; Manabu Hanano
Uptake of colchicine, a microtubular system disrupting agent, by isolated rat hepatocytes.
Pharmaceutical research 1989;6(3):235-8.
1989: Yuichi Sugiyama; Manabu Hanano
Receptor-mediated transport of peptide hormones and its importance in the overall hormone disposition in the body.
Pharmaceutical research 1989;6(3):192-202.
1989: K Yachi; Yuichi Sugiyama; Yasufumi Sawada; Tatsuji Iga; Y Ikeda; G Toda; Manabu Hanano
Characterization of Rose Bengal binding to sinusoidal and bile canalicular plasma membrane from rat liver.
Biochimica et biophysica acta 1989;978(1):1-7.
1989: D C Kim; Yuichi Sugiyama; T Fuwa; S Sakamoto; Tatsuji Iga; Manabu Hanano
Kinetic analysis of the elimination process of human epidermal growth factor (hEGF) in rats.
Biochemical pharmacology 1989;38(2):241-9.
1989: K Okudaira; Yasufumi Sawada; Yuichi Sugiyama; Tatsuji Iga; Manabu Hanano
Effect of quinidine on the hepatic uptake of digoxin in guinea pigs.
Journal of pharmacobio-dynamics 1989;12(1):24-30.
1988: H Sato; Yuichi Sugiyama; Y Sawada; T Iga; S Sakamoto; T Fuwa; Manabu Hanano
Dynamic determination of kinetic parameters for the interaction between polypeptide hormones and cell-surface receptors in the perfused rat liver by the multiple-indicator dilution method.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(21):8355-9.
1988: Konstanty Wierzba; Yuichi Sugiyama; Tatsuji Iga; Manabu Hanano
Kinetic study on the mechanism of tissue distribution of vinblastine.
Journal of pharmacobio-dynamics 1988;11(10):651-61.
1988: S Kawasaki; Yuichi Sugiyama; Tatsuji Iga; Manabu Hanano; T Beppu; M Sugiura; K Sanjo; Y Idezuki
Hepatic clearances of antipyrine, indocyanine green, and galactose in normal subjects and in patients with chronic liver diseases.
Clinical pharmacology and therapeutics 1988;44(2):217-24.
1988: T H Lin; Yuichi Sugiyama; Yasufumi Sawada; Tatsuji Iga; Manabu Hanano
Dialyzable serum cofactor(s) required for the protein-mediated transport of DL-propranolol into rat brain.
Biochemical pharmacology 1988;37(15):2957-61.
1988: K Okudaira; Yasufumi Sawada; Yuichi Sugiyama; Tatsuji Iga; Manabu Hanano
Effects of basic drugs on the hepatic transport of cardiac glycosides in rats.
Biochemical pharmacology 1988;37(15):2949-55.
1988: S Miyauchi; Yuichi Sugiyama; Tatsuji Iga; Manabu Hanano
Membrane-limited hepatic transport of the conjugative metabolites of 4-methylumbelliferone in rats.
Journal of pharmaceutical sciences 1988;77(8):688-92.
1988: Hideyoshi Harashima; Yuichi Sugiyama; Yasufumi Sawada; K Shigenobu; Y Kasuya; Tatsuji Iga; Manabu Hanano
Kinetic analysis of the positive inotropic action (PIA) of ouabain in isolated perfused rabbit heart. Slow onset of PIA and slow binding to Na+, K+-adenosine triphosphatase.
Journal of pharmacobio-dynamics 1988;11(8):533-40.
1988: Hideyoshi Harashima; Yuichi Sugiyama; Tatsuji Iga; Manabu Hanano
Nonlinear tissue distribution of ouabain in rabbits.
Drug metabolism and disposition: the biological fate of chemicals 1988;16(4):645-9.
1988: Takeshi Iwatsubo; Yuichi Sugiyama; Y Miyamoto; F H Leibach; H Suzuki; Tatsuji Iga; Manabu Hanano
Effects of phenothiazine derivatives on the microclimate-pH in the rat jejunum.
Journal of pharmaceutical sciences 1988;77(7):586-90.
1988: H Sato; Yuichi Sugiyama; Yasufumi Sawada; Tatsuji Iga; Manabu Hanano
In vivo evidence for the specific binding of human beta-endorphin to the lung and liver of the rat.
Biochemical pharmacology 1988;37(11):2273-8.
1988: S C Tsao; Yuichi Sugiyama; K Shinmura; Yasufumi Sawada; S Nagase; Tatsuji Iga; Manabu Hanano
Protein-mediated hepatic uptake of rose bengal in analbuminemic mutant rats (NAR). Albumin is not indispensable to the protein-mediated transport of rose bengal.
Drug metabolism and disposition: the biological fate of chemicals 1988;16(3):482-9.
1988: S C Tsao; Yuichi Sugiyama; Yasufumi Sawada; Tatsuji Iga; Manabu Hanano
Kinetic analysis of albumin-mediated uptake of warfarin by perfused rat liver.
Journal of pharmacokinetics and biopharmaceutics 1988;16(2):165-81.
1988: A Kurihara; H Suzuki; Yasufumi Sawada; Yuichi Sugiyama; Tatsuji Iga; Manabu Hanano
Transport of digoxin into brain microvessels and choroid plexuses isolated from guinea pig.
Journal of pharmaceutical sciences 1988;77(4):347-52.
1988: K Yachi; Yuichi Sugiyama; H Sato; D C Kim; T Fuwa; Tatsuji Iga; Manabu Hanano
Comparison of specific binding of human epidermal growth factor (EGF) to sinusoidal and bile canalicular membranes isolated from rat liver.
Journal of biochemistry 1988;103(3):448-51.
1988: D C Kim; Yuichi Sugiyama; H Satoh; T Fuwa; Tatsuji Iga; Manabu Hanano
Kinetic analysis of in vivo receptor-dependent binding of human epidermal growth factor by rat tissues.
Journal of pharmaceutical sciences 1988;77(3):200-7.
1988: H Suzuki; Yasufumi Sawada; Yuichi Sugiyama; Tatsuji Iga; Manabu Hanano
Efflux of cimetidine from the rat cerebrospinal fluid.
Drug metabolism and disposition: the biological fate of chemicals 1988;16(2):328-30.
1988: T H Lin; Yuichi Sugiyama; Yasufumi Sawada; S Kawasaki; Tatsuji Iga; Manabu Hanano
Effect of serum from renal failure and cirrhotic patients on the blood-brain barrier permeability to DL-propranolol in rats.
Drug metabolism and disposition: the biological fate of chemicals 1988;16(2):290-5.
1987: H Suzuki; Yasufumi Sawada; Yuichi Sugiyama; Tatsuji Iga; Manabu Hanano
Anion exchanger mediates benzylpenicillin transport in rat choroid plexus.
The Journal of pharmacology and experimental therapeutics 1987;243(3):1147-52.
1987: Konstanty Wierzba; Yuichi Sugiyama; K Okudaira; Tatsuji Iga; Manabu Hanano
Tubulin as a major determinant of tissue distribution of vincristine.
Journal of pharmaceutical sciences 1987;76(12):872-5.
1987: T H Lin; Yasufumi Sawada; Yuichi Sugiyama; Tatsuji Iga; Manabu Hanano
Inhibition of blood-brain barrier permeability to DL-propranolol by serum from acute renal failure rats.
Biochemical pharmacology 1987;36(20):3425-31.
1987: A Kurihara; H Suzuki; Yasufumi Sawada; Yuichi Sugiyama; Tatsuji Iga; Manabu Hanano
Uptake of propranolol by microvessels isolated from bovine brain.
Journal of pharmaceutical sciences 1987;76(10):759-64.
1987: S Miyauchi; Yuichi Sugiyama; H Sato; Yasufumi Sawada; Tatsuji Iga; Manabu Hanano
Effect of a diffusional barrier to a metabolite across hepatocytes on its kinetics in "enzyme-distributed" models: a computer-aided simulation study.
Journal of pharmacokinetics and biopharmaceutics 1987;15(4):399-421.
1987: H Sato; Yuichi Sugiyama; Yasufumi Sawada; Tatsuji Iga; Manabu Hanano
Physiologically based pharmacokinetics of radioiodinated human beta-endorphin in rats. An application of the capillary membrane-limited model.
Drug metabolism and disposition: the biological fate of chemicals 1987;15(4):540-50.
1981: Y Igari; Yuichi Sugiyama; S Awazu; Manabu Hanano
Interspecies difference in drug protein binding-temperature and protein concentration dependency: effect on calculation of effective protein fraction.
Journal of pharmaceutical sciences 1981;70(9):1049-53.