Yuichi Sugiyama

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Living Beings

Anatomy

Physiology

Chemicals & Drugs

Concepts & Ideas

Sign-in to see full Profile

Sign-in to see all Coauthors

Publications

TOP 3
Hirouchi Masakazu; Kusuhara Hiroyuki; Onuki Reiko; Ogilvie Brian W; Parkinson Andrew; Sugiyama Yuichi
Construction of triple-transfected cells [organic anion-transporting polypeptide (OATP) 1B1/multidrug resistance-associated protein (MRP) 2/MRP3 and OATP1B1/MRP2/MRP4] for analysis of the sinusoidal function of MRP3 and MRP4.
Watanabe Tomoko; Maeda Kazuya; Kondo Tsunenori; Nakayama Hideki; Horita Shigeru; Kusuhara Hiroyuki; Sugiyama Yuichi
Prediction of the hepatic and renal clearance of transporter substrates in rats using in vitro uptake experiments.
Shitara Yoshihisa; Nagamatsu Yoshiko; Wada Satomi; Sugiyama Yuichi; Horie Toshiharu
Long-lasting inhibition of the transporter-mediated hepatic uptake of sulfobromophthalein by cyclosporin a in rats.

Sign-in to see all Publications

Sign in free and see...

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the visualized research activity
of experts around the globe

Sign-in to see more

Geonetwork of Yuichi Sugiyama (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

Sign-in to see more

All Publications

2009: Hirouchi Masakazu; Kusuhara Hiroyuki; Onuki Reiko; Ogilvie Brian W; Parkinson Andrew; Sugiyama Yuichi
Construction of triple-transfected cells [organic anion-transporting polypeptide (OATP) 1B1/multidrug resistance-associated protein (MRP) 2/MRP3 and OATP1B1/MRP2/MRP4] for analysis of the sinusoidal function of MRP3 and MRP4.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(10):2103-11.
2009: Watanabe Tomoko; Maeda Kazuya; Kondo Tsunenori; Nakayama Hideki; Horita Shigeru; Kusuhara Hiroyuki; Sugiyama Yuichi
Prediction of the hepatic and renal clearance of transporter substrates in rats using in vitro uptake experiments.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(7):1471-9.
2009: Shitara Yoshihisa; Nagamatsu Yoshiko; Wada Satomi; Sugiyama Yuichi; Horie Toshiharu
Long-lasting inhibition of the transporter-mediated hepatic uptake of sulfobromophthalein by cyclosporin a in rats.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(6):1172-8.
2009: Miyagawa Mayuko; Maeda Kazuya; Aoyama Akinori; Sugiyama Yuichi
The eighth and ninth transmembrane domains in organic anion transporting polypeptide 1B1 affect the transport kinetics of estrone-3-sulfate and estradiol-17beta-D-glucuronide.
The Journal of pharmacology and experimental therapeutics 2009;329(2):551-7.
2009: Liu Ke-Xin; Kato Yukio; Matsumoto Kunio; Nakamura Toshikazu; Kaku Taiichi; Sugiyama Yuichi
Characterization of the enhancing effect of protamine on the proliferative activity of hepatocyte growth factor in rat hepatocytes.
Pharmaceutical research 2009;26(4):1012-21.
2009: Kusama Makiko; Maeda Kazuya; Chiba Koji; Aoyama Akinori; Sugiyama Yuichi
Prediction of the effects of genetic polymorphism on the pharmacokinetics of CYP2C9 substrates from in vitro data.
Pharmaceutical research 2009;26(4):822-35.
2009: Matsushima Soichiro; Maeda Kazuya; Inoue Katsuhisa; Ohta Kin-ya; Yuasa Hiroaki; Kondo Tsunenori; Nakayama Hideki; Horita Shigeru; Kusuhara Hiroyuki; Sugiyama Yuichi
The inhibition of human multidrug and toxin extrusion 1 is involved in the drug-drug interaction caused by cimetidine.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(3):555-9.
2009: Imai Satoki; Kikuchi Ryota; Kusuhara Hiroyuki; Yagi Shintaro; Shiota Kunio; Sugiyama Yuichi
Analysis of DNA methylation and histone modification profiles of liver-specific transporters.
Molecular pharmacology 2009;75(3):568-76.
2009: Ose Atsushi; Ito Mototsugu; Kusuhara Hiroyuki; Yamatsugu Kenzo; Kanai Motomu; Shibasaki Masakatsu; Hosokawa Masakiyo; Schuetz John D; Sugiyama Yuichi
Limited brain distribution of [3R,4R,5S]-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate phosphate (Ro 64-0802), a pharmacologically active form of oseltamivir, by active efflux across the blood-brain barrier mediated by organic anion transporter 3 (Oat3/Slc22a8) and multidrug resistance-associated protein 4 (Mrp4/Abcc4).
Drug metabolism and disposition: the biological fate of chemicals 2009;37(2):315-21.
2009: Watanabe Takao; Kusuhara Hiroyuki; Maeda Kazuya; Shitara Yoshihisa; Sugiyama Yuichi
Physiologically based pharmacokinetic modeling to predict transporter-mediated clearance and distribution of pravastatin in humans.
The Journal of pharmacology and experimental therapeutics 2009;328(2):652-62.
2009: Hisaka Akihiro; Kusama Makiko; Ohno Yoshiyuki; Sugiyama Yuichi; Suzuki Hiroshi
A proposal for a pharmacokinetic interaction significance classification system (PISCS) based on predicted drug exposure changes and its potential application to alert classifications in product labelling.
Clinical pharmacokinetics 2009;48(10):653-66.
2009: Sugiyama Yuichi
Effective use of microdosing and Positron Emission Tomography (PET) studies on new drug discovery and development.
Drug metabolism and pharmacokinetics 2009;24(2):127-9.
2009: Kusuhara Hiroyuki; Sugiyama Yuichi
In vitro-in vivo extrapolation of transporter-mediated clearance in the liver and kidney.
Drug metabolism and pharmacokinetics 2009;24(1):37-52.
2008: Kitamura Yoshiaki; Hirouchi Masakazu; Kusuhara Hiroyuki; Schuetz John D; Sugiyama Yuichi
Increasing systemic exposure of methotrexate by active efflux mediated by multidrug resistance-associated protein 3 (mrp3/abcc3).
The Journal of pharmacology and experimental therapeutics 2008;327(2):465-73.
2008: Kitamura Satoshi; Maeda Kazuya; Wang Yi; Sugiyama Yuichi
Involvement of multiple transporters in the hepatobiliary transport of rosuvastatin.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(10):2014-23.
2008: Kobayashi Kazuhiro; Ito Kousei; Takada Tappei; Sugiyama Yuichi; Suzuki Hiroshi
Functional analysis of nonsynonymous single nucleotide polymorphism type ATP-binding cassette transmembrane transporter subfamily C member 3.
Pharmacogenetics and genomics 2008;18(9):823-33.
2008: Kitamura Satoshi; Maeda Kazuya; Sugiyama Yuichi
Recent progresses in the experimental methods and evaluation strategies of transporter functions for the prediction of the pharmacokinetics in humans.
Naunyn-Schmiedeberg's archives of pharmacology 2008;377(4-6):617-28.
2008: Enokizono Junichi; Kusuhara Hiroyuki; Ose Atsushi; Schinkel Alfred H; Sugiyama Yuichi
Quantitative investigation of the role of breast cancer resistance protein (Bcrp/Abcg2) in limiting brain and testis penetration of xenobiotic compounds.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(6):995-1002.
2008: Kitamura Yoshiaki; Koto Hisao; Matsuura Shinobu; Kawabata Takeshi; Tsuchiya Hiroshi; Kusuhara Hiroyuki; Tsujimoto Hajime; Sugiyama Yuichi
Modest effect of impaired P-glycoprotein on the plasma concentrations of fexofenadine, quinidine, and loperamide following oral administration in collies.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(5):807-10.
2008: Matsushima Soichiro; Maeda Kazuya; Hayashi Hisamitsu; Debori Yasuyuki; Schinkel Alfred H; Schuetz John D; Kusuhara Hiroyuki; Sugiyama Yuichi
Involvement of multiple efflux transporters in hepatic disposition of fexofenadine.
Molecular pharmacology 2008;73(5):1474-83.
2008: Matsushima Soichiro; Maeda Kazuya; Ishiguro Naoki; Igarashi Takashi; Sugiyama Yuichi
Investigation of the inhibitory effects of various drugs on the hepatic uptake of fexofenadine in humans.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(4):663-9.
2008: Ose Atsushi; Kusuhara Hiroyuki; Yamatsugu Kenzo; Kanai Motomu; Shibasaki Masakatsu; Fujita Takuya; Yamamoto Akira; Sugiyama Yuichi
P-glycoprotein restricts the penetration of oseltamivir across the blood-brain barrier.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(2):427-34.
2008: Saji Takami; Kikuchi Ryota; Kusuhara Hiroyuki; Kim Insook; Gonzalez Frank J; Sugiyama Yuichi
Transcriptional regulation of human and mouse organic anion transporter 1 by hepatocyte nuclear factor 1 alpha/beta.
The Journal of pharmacology and experimental therapeutics 2008;324(2):784-90.
2008: Maeda Kazuya; Sugiyama Yuichi
Impact of genetic polymorphisms of transporters on the pharmacokinetic, pharmacodynamic and toxicological properties of anionic drugs.
Drug metabolism and pharmacokinetics 2008;23(4):223-35.
2007: Kikuchi Ryota; Kusuhara Hiroyuki; Hattori Naka; Kim Insook; Shiota Kunio; Gonzalez Frank J; Sugiyama Yuichi
Regulation of tissue-specific expression of the human and mouse urate transporter 1 gene by hepatocyte nuclear factor 1 alpha/beta and DNA methylation.
Molecular pharmacology 2007;72(6):1619-25.
2007: Yamada Akihiro; Maeda Kazuya; Kamiyama Emi; Sugiyama Daisuke; Kondo Tsunenori; Shiroyanagi Yoshiyuki; Nakazawa Hayakazu; Okano Teruo; Adachi Masashi; Schuetz John D; Adachi Yasuhisa; Hu Zhuohan; Kusuhara Hiroyuki; Sugiyama Yuichi
Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(12):2166-76.
2007: Enokizono Junichi; Kusuhara Hiroyuki; Sugiyama Yuichi
Effect of breast cancer resistance protein (Bcrp/Abcg2) on the disposition of phytoestrogens.
Molecular pharmacology 2007;72(4):967-75.
2007: Ando Tomohiro; Kusuhara Hiroyuki; Merino Gracia; Alvarez Ana I; Schinkel Alfred H; Sugiyama Yuichi
Involvement of breast cancer resistance protein (ABCG2) in the biliary excretion mechanism of fluoroquinolones.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(10):1873-9.
2007: Nozaki Yoshitane; Kusuhara Hiroyuki; Kondo Tsunenori; Iwaki Masahiro; Shiroyanagi Yoshiyuki; Nakayama Hideki; Horita Shigeru; Nakazawa Hayakazu; Okano Teruo; Sugiyama Yuichi
Species difference in the inhibitory effect of nonsteroidal anti-inflammatory drugs on the uptake of methotrexate by human kidney slices.
The Journal of pharmacology and experimental therapeutics 2007;322(3):1162-70.
2007: Ito Mototsugu; Onuki Reiko; Bando Yoshio; Tohyama Masaya; Sugiyama Yuichi
Phosphorylated PKR contributes the induction of GRP94 under ER stress.
Biochemical and biophysical research communications 2007;360(3):615-20.
2007: Hayashi Hisamitsu; Sugiyama Yuichi
4-phenylbutyrate enhances the cell surface expression and the transport capacity of wild-type and mutated bile salt export pumps.
Hepatology (Baltimore, Md.) 2007;45(6):1506-16.
2007: Enokizono Junichi; Kusuhara Hiroyuki; Sugiyama Yuichi
Regional expression and activity of breast cancer resistance protein (Bcrp/Abcg2) in mouse intestine: overlapping distribution with sulfotransferases.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(6):922-8.
2007: Ci Lei; Kusuhara Hiroyuki; Adachi Masashi; Schuetz John D; Takeuchi Kenji; Sugiyama Yuichi
Involvement of MRP4 (ABCC4) in the luminal efflux of ceftizoxime and cefazolin in the kidney.
Molecular pharmacology 2007;71(6):1591-7.
2007: Nozaki Yoshitane; Kusuhara Hiroyuki; Kondo Tsunenori; Hasegawa Maki; Shiroyanagi Yoshiyuki; Nakazawa Hayakazu; Okano Teruo; Sugiyama Yuichi
Characterization of the uptake of organic anion transporter (OAT) 1 and OAT3 substrates by human kidney slices.
The Journal of pharmacology and experimental therapeutics 2007;321(1):362-9.
2007: Komoriya Kazumi; Kato Yukio; Hayashi Yujiro; Ohsuye Kazuhiro; Nishigaki Ryuichiro; Sugiyama Yuichi
Characterization of the hepatic disposition of lanoteplase, a rationally designed variant of tissue plasminogen activator in rodents.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(3):469-75.
2007: Imaoka Tomoki; Kusuhara Hiroyuki; Adachi Masashi; Schuetz John D; Takeuchi Kenji; Sugiyama Yuichi
Functional involvement of multidrug resistance-associated protein 4 (MRP4/ABCC4) in the renal elimination of the antiviral drugs adefovir and tenofovir.
Molecular pharmacology 2007;71(2):619-27.
2007: Enokizono Junichi; Kusuhara Hiroyuki; Sugiyama Yuichi
Involvement of breast cancer resistance protein (BCRP/ABCG2) in the biliary excretion and intestinal efflux of troglitazone sulfate, the major metabolite of troglitazone with a cholestatic effect.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(2):209-14.
2007: Kusuhara Hiroyuki; Sugiyama Yuichi
ATP-binding cassette, subfamily G (ABCG family).
Pflügers Archiv : European journal of physiology 2007;453(5):735-44.
2007: Hasegawa Maki; Kusuhara Hiroyuki; Adachi Masashi; Schuetz John D; Takeuchi Kenji; Sugiyama Yuichi
Multidrug resistance-associated protein 4 is involved in the urinary excretion of hydrochlorothiazide and furosemide.
Journal of the American Society of Nephrology : JASN 2007;18(1):37-45.
2006: Shitara Yoshihisa; Sugiyama Yuichi
Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: drug-drug interactions and interindividual differences in transporter and metabolic enzyme functions.
Pharmacology & therapeutics 2006;112(1):71-105.
2006: Takano Akihiro; Suhara Tetsuya; Yasuno Fumihiko; Suzuki Kazutoshi; Takahashi Hidehiko; Morimoto Takuya; Lee Young-Joo; Kusuhara Hiroyuki; Sugiyama Yuichi; Okubo Yoshiro
The antipsychotic sultopride is overdosed--a PET study of drug-induced receptor occupancy in comparison with sulpiride.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2006;9(5):539-45.
2006: Ikoma Yoko; Takano Akihiro; Ito Hiroshi; Kusuhara Hiroyuki; Sugiyama Yuichi; Arakawa Ryosuke; Fukumura Toshimitsu; Nakao Ryuji; Suzuki Kazutoshi; Suhara Tetsuya
Quantitative analysis of 11C-verapamil transfer at the human blood-brain barrier for evaluation of P-glycoprotein function.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2006;47(9):1531-7.
2006: Takano Akihiro; Kusuhara Hiroyuki; Suhara Tetsuya; Ieiri Ichiro; Morimoto Takuya; Lee Young-Joo; Maeda Jun; Ikoma Yoko; Ito Hiroshi; Suzuki Kazutoshi; Sugiyama Yuichi
Evaluation of in vivo P-glycoprotein function at the blood-brain barrier among MDR1 gene polymorphisms by using 11C-verapamil.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2006;47(9):1427-33.
2006: Kikuchi Ryota; Kusuhara Hiroyuki; Hattori Naka; Shiota Kunio; Kim Insook; Gonzalez Frank J; Sugiyama Yuichi
Regulation of the expression of human organic anion transporter 3 by hepatocyte nuclear factor 1alpha/beta and DNA methylation.
Molecular pharmacology 2006;70(3):887-96.
2006: Mita Sachiko; Suzuki Hiroshi; Akita Hidetaka; Hayashi Hisamitsu; Onuki Reiko; Hofmann Alan F; Sugiyama Yuichi
Inhibition of bile acid transport across Na+/taurocholate cotransporting polypeptide (SLC10A1) and bile salt export pump (ABCB 11)-coexpressing LLC-PK1 cells by cholestasis-inducing drugs.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(9):1575-81.
2006: Yamashiro Wakaba; Maeda Kazuya; Hirouchi Masakazu; Adachi Yasuhisa; Hu Zhuohan; Sugiyama Yuichi
Involvement of transporters in the hepatic uptake and biliary excretion of valsartan, a selective antagonist of the angiotensin II AT1-receptor, in humans.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(7):1247-54.
2006: Hirano Masaru; Maeda Kazuya; Shitara Yoshihisa; Sugiyama Yuichi
Drug-drug interaction between pitavastatin and various drugs via OATP1B1.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(7):1229-36.
2006: Sakamoto Shingo; Suzuki Hiroshi; Kusuhara Hiroyuki; Sugiyama Yuichi
Efflux mechanism of taurocholate across the rat intestinal basolateral membrane.
Molecular pharmaceutics 2006;3(3):275-81.
2006: Maeda Kazuya; Ieiri Ichiro; Yasuda Kuninobu; Fujino Akiharu; Fujiwara Hiroaki; Otsubo Kenji; Hirano Masaru; Watanabe Takao; Kitamura Yoshiaki; Kusuhara Hiroyuki; Sugiyama Yuichi
Effects of organic anion transporting polypeptide 1B1 haplotype on pharmacokinetics of pravastatin, valsartan, and temocapril.
Clinical pharmacology and therapeutics 2006;79(5):427-39.
2006: Han Ying; Sugiyama Yuichi
Expression and regulation of breast cancer resistance protein and multidrug resistance associated protein 2 in BALB/c mice.
Biological & pharmaceutical bulletin 2006;29(5):1032-5.
2006: Tahara Harunobu; Kusuhara Hiroyuki; Maeda Kazuya; Koepsell Hermann; Fuse Eiichi; Sugiyama Yuichi
Inhibition of oat3-mediated renal uptake as a mechanism for drug-drug interaction between fexofenadine and probenecid.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(5):743-7.
2006: Shitara Yoshihisa; Horie Toshiharu; Sugiyama Yuichi
Transporters as a determinant of drug clearance and tissue distribution.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2006;27(5):425-46.
2006: Mita Sachiko; Suzuki Hiroshi; Akita Hidetaka; Hayashi Hisamitsu; Onuki Reiko; Hofmann Alan F; Sugiyama Yuichi
Vectorial transport of unconjugated and conjugated bile salts by monolayers of LLC-PK1 cells doubly transfected with human NTCP and BSEP or with rat Ntcp and Bsep.
American journal of physiology. Gastrointestinal and liver physiology 2006;290(3):G550-6.
2006: Tahara Harunobu; Kusuhara Hiroyuki; Chida Michihiro; Fuse Eiichi; Sugiyama Yuichi
Is the monkey an appropriate animal model to examine drug-drug interactions involving renal clearance? Effect of probenecid on the renal elimination of H2 receptor antagonists.
The Journal of pharmacology and experimental therapeutics 2006;316(3):1187-94.
2006: Lee Young-Joo; Maeda Jun; Kusuhara Hiroyuki; Okauchi Takashi; Inaji Motoki; Nagai Yuji; Obayashi Shigeru; Nakao Ryuji; Suzuki Kazutoshi; Sugiyama Yuichi; Suhara Tetsuya
In vivo evaluation of P-glycoprotein function at the blood-brain barrier in nonhuman primates using [11C]verapamil.
The Journal of pharmacology and experimental therapeutics 2006;316(2):647-53.
2006: Maeda Kazuya; Kambara Miyuki; Tian Ying; Hofmann Alan F; Sugiyama Yuichi
Uptake of ursodeoxycholate and its conjugates by human hepatocytes: role of Na(+)-taurocholate cotransporting polypeptide (NTCP), organic anion transporting polypeptide (OATP) 1B1 (OATP-C), and oatp1B3 (OATP8).
Molecular pharmaceutics 2006;3(1):70-7.
2005: Hayashi Hisamitsu; Takada Tappei; Suzuki Hiroshi; Onuki Reiko; Hofmann Alan F; Sugiyama Yuichi
Transport by vesicles of glycine- and taurine-conjugated bile salts and taurolithocholate 3-sulfate: a comparison of human BSEP with rat Bsep.
Biochimica et biophysica acta 2005;1738(1-3):54-62.
2005: Ito Kousei; Suzuki Hiroshi; Horie Toshiharu; Sugiyama Yuichi
Apical/basolateral surface expression of drug transporters and its role in vectorial drug transport.
Pharmaceutical research 2005;22(10):1559-77.
2005: Shimizu Maki; Fuse Kaori; Okudaira Kazuho; Nishigaki Ryuichiro; Maeda Kazuya; Kusuhara Hiroyuki; Sugiyama Yuichi
Contribution of OATP (organic anion-transporting polypeptide) family transporters to the hepatic uptake of fexofenadine in humans.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(10):1477-81.
2005: Tahara Harunobu; Kusuhara Hiroyuki; Endou Hitoshi; Koepsell Hermann; Imaoka Tomoki; Fuse Eiichi; Sugiyama Yuichi
A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters.
The Journal of pharmacology and experimental therapeutics 2005;315(1):337-45.
2005: Hirano Masaru; Maeda Kazuya; Matsushima Soichiro; Nozaki Yoshitane; Kusuhara Hiroyuki; Sugiyama Yuichi
Involvement of BCRP (ABCG2) in the biliary excretion of pitavastatin.
Molecular pharmacology 2005;68(3):800-7.
2005: Matsushima Soichiro; Maeda Kazuya; Kondo Chihiro; Hirano Masaru; Sasaki Makoto; Suzuki Hiroshi; Sugiyama Yuichi
Identification of the hepatic efflux transporters of organic anions using double-transfected Madin-Darby canine kidney II cells expressing human organic anion-transporting polypeptide 1B1 (OATP1B1)/multidrug resistance-associated protein 2, OATP1B1/multidrug resistance 1, and OATP1B1/breast cancer resistance protein.
The Journal of pharmacology and experimental therapeutics 2005;314(3):1059-67.
2005: Watanabe Tomoko; Onuki Reiko; Yamashita Shinji; Taira Kazunari; Sugiyama Yuichi
Construction of a functional transporter analysis system using MDR1 knockdown Caco-2 cells.
Pharmaceutical research 2005;22(8):1287-93.
2005: Hirano Masaru; Maeda Kazuya; Hayashi Hisamitsu; Kusuhara Hiroyuki; Sugiyama Yuichi
Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin.
The Journal of pharmacology and experimental therapeutics 2005;314(2):876-82.
2005: Morita Naomi; Kusuhara Hiroyuki; Nozaki Yoshitane; Endou Hitoshi; Sugiyama Yuichi
Functional involvement of rat organic anion transporter 2 (Slc22a7) in the hepatic uptake of the nonsteroidal anti-inflammatory drug ketoprofen.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(8):1151-7.
2005: Kuroda Misaki; Kusuhara Hiroyuki; Endou Hitoshi; Sugiyama Yuichi
Rapid elimination of cefaclor from the cerebrospinal fluid is mediated by a benzylpenicillin-sensitive mechanism distinct from organic anion transporter 3.
The Journal of pharmacology and experimental therapeutics 2005;314(2):855-61.
2005: Takada Tappei; Suzuki Hiroshi; Gotoh Yukiko; Sugiyama Yuichi
Regulation of the cell surface expression of human BCRP/ABCG2 by the phosphorylation state of Akt in polarized cells.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(7):905-9.
2005: Tahara Harunobu; Kusuhara Hiroyuki; Fuse Eiichi; Sugiyama Yuichi
P-glycoprotein plays a major role in the efflux of fexofenadine in the small intestine and blood-brain barrier, but only a limited role in its biliary excretion.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(7):963-8.
2005: Hirouchi Masakazu; Suzuki Hiroshi; Sugiyama Yuichi
Treatment of hyperbilirubinemia in Eisai hyperbilirubinemic rat by transfecting human MRP2/ABCC2 gene.
Pharmaceutical research 2005;22(4):661-6.
2005: Tahara Harunobu; Shono Masayuki; Kusuhara Hiroyuki; Kinoshita Hajime; Fuse Eiichi; Takadate Akira; Otagiri Masaki; Sugiyama Yuichi
Molecular cloning and functional analyses of OAT1 and OAT3 from cynomolgus monkey kidney.
Pharmaceutical research 2005;22(4):647-60.
2005: Kondo Chihiro; Onuki Reiko; Kusuhara Hiroyuki; Suzuki Hiroshi; Suzuki Michiko; Okudaira Noriko; Kojima Maho; Ishiwata Kazuya; Jonker Johan W; Sugiyama Yuichi
Lack of improvement of oral absorption of ME3277 by prodrug formation is ascribed to the intestinal efflux mediated by breast cancer resistant protein (BCRP/ABCG2).
Pharmaceutical research 2005;22(4):613-8.
2005: Hayashi Hisamitsu; Takada Tappei; Suzuki Hiroshi; Akita Hidetaka; Sugiyama Yuichi
Two common PFIC2 mutations are associated with the impaired membrane trafficking of BSEP/ABCB11.
Hepatology (Baltimore, Md.) 2005;41(4):916-24.
2005: Takada Tappei; Suzuki Hiroshi; Sugiyama Yuichi
Characterization of polarized expression of point- or deletion-mutated human BCRP/ABCG2 in LLC-PK1 cells.
Pharmaceutical research 2005;22(3):458-64.
2005: Adachi Yasuhisa; Suzuki Hiroshi; Schinkel Alfred H; Sugiyama Yuichi
Role of breast cancer resistance protein (Bcrp1/Abcg2) in the extrusion of glucuronide and sulfate conjugates from enterocytes to intestinal lumen.
Molecular pharmacology 2005;67(3):923-8.
2005: Hirono Shuichi; Nakagome Izumi; Imai Rie; Maeda Kazuya; Kusuhara Hiroyuki; Sugiyama Yuichi
Estimation of the three-dimensional pharmacophore of ligands for rat multidrug-resistance-associated protein 2 using ligand-based drug design techniques.
Pharmaceutical research 2005;22(2):260-9.
2005: Kusuhara Hiroyuki; Sugiyama Yuichi
Active efflux across the blood-brain barrier: role of the solute carrier family.
NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics 2005;2(1):73-85.
2005: Lee Young-Joo; Kusuhara Hiroyuki; Jonker Johan W; Schinkel Alfred H; Sugiyama Yuichi
Investigation of efflux transport of dehydroepiandrosterone sulfate and mitoxantrone at the mouse blood-brain barrier: a minor role of breast cancer resistance protein.
The Journal of pharmacology and experimental therapeutics 2005;312(1):44-52.
2005: Mita Sachiko; Suzuki Hiroshi; Akita Hidetaka; Stieger Bruno; Meier Peter J; Hofmann Alan F; Sugiyama Yuichi
Vectorial transport of bile salts across MDCK cells expressing both rat Na+-taurocholate cotransporting polypeptide and rat bile salt export pump.
American journal of physiology. Gastrointestinal and liver physiology 2005;288(1):G159-67.
2004: Kikuchi Ryota; Kusuhara Hiroyuki; Abe Takaaki; Endou Hitoshi; Sugiyama Yuichi
Involvement of multiple transporters in the efflux of 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors across the blood-brain barrier.
The Journal of pharmacology and experimental therapeutics 2004;311(3):1147-53.
2004: Iwai Megumi; Suzuki Hiroshi; Ieiri Ichiro; Otsubo Kenji; Sugiyama Yuichi
Functional analysis of single nucleotide polymorphisms of hepatic organic anion transporter OATP1B1 (OATP-C).
Pharmacogenetics 2004;14(11):749-57.
2004: Nagata Yoshinori; Kusuhara Hiroyuki; Imaoka Tomoki; Endou Hitoshi; Sugiyama Yuichi
Involvement of rat organic anion transporter 3 in the uptake of an organic herbicide, 2,4-dichlorophenoxyacetate, by the isolated rat choroid plexus.
Journal of pharmaceutical sciences 2004;93(11):2724-32.
2004: Kondo Chihiro; Suzuki Hiroshi; Itoda Masaya; Ozawa Shogo; Sawada Jun-ichi; Kobayashi Daisuke; Ieiri Ichiro; Mine Kazunori; Ohtsubo Kenji; Sugiyama Yuichi
Functional analysis of SNPs variants of BCRP/ABCG2.
Pharmaceutical research 2004;21(10):1895-903.
2004: Kusuhara Hiroyuki; Sugiyama Yuichi
Efflux transport systems for organic anions and cations at the blood-CSF barrier.
Advanced drug delivery reviews 2004;56(12):1741-63.
2004: Hirano Masaru; Maeda Kazuya; Shitara Yoshihisa; Sugiyama Yuichi
Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans.
The Journal of pharmacology and experimental therapeutics 2004;311(1):139-46.
2004: Sasaki Makoto; Suzuki Hiroshi; Aoki Jun; Ito Kousei; Meier Peter J; Sugiyama Yuichi
Prediction of in vivo biliary clearance from the in vitro transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II monolayer expressing both rat organic anion transporting polypeptide 4 and multidrug resistance associated protein 2.
Molecular pharmacology 2004;66(3):450-9.
2004: Nagata Yoshinori; Kusuhara Hiroyuki; Hirono Shuichi; Endou Hitoshi; Sugiyama Yuichi
Carrier-mediated uptake of H2-receptor antagonists by the rat choroid plexus: involvement of rat organic anion transporter 3.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(9):1040-7.
2004: Mizuno Naomi; Suzuki Michiko; Kusuhara Hiroyuki; Suzuki Hiroshi; Takeuchi Kenji; Niwa Takuro; Jonker Johan W; Sugiyama Yuichi
Impaired renal excretion of 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl) benzothiazole (E3040) sulfate in breast cancer resistance protein (BCRP1/ABCG2) knockout mice.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(9):898-901.
2004: Tohyama Kimio; Kusuhara Hiroyuki; Sugiyama Yuichi
Involvement of multispecific organic anion transporter, Oatp14 (Slc21a14), in the transport of thyroxine across the blood-brain barrier.
Endocrinology 2004;145(9):4384-91.
2004: Imaoka Tomoki; Kusuhara Hiroyuki; Adachi-Akahane Satomi; Hasegawa Maki; Morita Naomi; Endou Hitoshi; Sugiyama Yuichi
The renal-specific transporter mediates facilitative transport of organic anions at the brush border membrane of mouse renal tubules.
Journal of the American Society of Nephrology : JASN 2004;15(8):2012-22.
2004: Hirouchi Masakazu; Suzuki Hiroshi; Itoda Masaya; Ozawa Shogo; Sawada Jun-ichi; Ieiri Ichiro; Ohtsubo Kenji; Sugiyama Yuichi
Characterization of the cellular localization, expression level, and function of SNP variants of MRP2/ABCC2.
Pharmaceutical research 2004;21(5):742-8.
2004: Nozaki Yoshitane; Kusuhara Hiroyuki; Endou Hitoshi; Sugiyama Yuichi
Quantitative evaluation of the drug-drug interactions between methotrexate and nonsteroidal anti-inflammatory drugs in the renal uptake process based on the contribution of organic anion transporters and reduced folate carrier.
The Journal of pharmacology and experimental therapeutics 2004;309(1):226-34.
2004: Deguchi Tsuneo; Kusuhara Hiroyuki; Takadate Akira; Endou Hitoshi; Otagiri Masaki; Sugiyama Yuichi
Characterization of uremic toxin transport by organic anion transporters in the kidney.
Kidney international 2004;65(1):162-74.
2004: Lee Young-Joo; Kusuhara Hiroyuki; Sugiyama Yuichi
Do multidrug resistance-associated protein-1 and -2 play any role in the elimination of estradiol-17 beta-glucuronide and 2,4-dinitrophenyl-S-glutathione across the blood-cerebrospinal fluid barrier?
Journal of pharmaceutical sciences 2004;93(1):99-107.
2003: Nishiyama Nobuhiro; Okazaki Souichiro; Cabral Horacio; Miyamoto Masaki; Kato Yukio; Sugiyama Yuichi; Nishio Kazuto; Matsumura Yasuhiro; Kataoka Kazunori
Novel cisplatin-incorporated polymeric micelles can eradicate solid tumors in mice.
Cancer research 2003;63(24):8977-83.
2003: Hayashi Asako; Suzuki Hiroshi; Itoh Ken; Yamamoto Masayuki; Sugiyama Yuichi
Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein 1 in mouse embryo fibroblasts.
Biochemical and biophysical research communications 2003;310(3):824-9.
2003: Sugiyama Daisuke; Kusuhara Hiroyuki; Taniguchi Hirokazu; Ishikawa Shumpei; Nozaki Yoshitane; Aburatani Hiroyuki; Sugiyama Yuichi
Functional characterization of rat brain-specific organic anion transporter (Oatp14) at the blood-brain barrier: high affinity transporter for thyroxine.
The Journal of biological chemistry 2003;278(44):43489-95.
2003: Sugiyama Daisuke; Kusuhara Hiroyuki; Lee Yong-Joo; Sugiyama Yuichi
Involvement of multidrug resistance associated protein 1 (Mrp1) in the efflux transport of 17beta estradiol-D-17beta-glucuronide (E217betaG) across the blood-brain barrier.
Pharmaceutical research 2003;20(9):1394-400.
2003: Mizuno Naomi; Niwa Takuro; Yotsumoto Yoshihisa; Sugiyama Yuichi
Impact of drug transporter studies on drug discovery and development.
Pharmacological reviews 2003;55(3):425-61.
2003: Adachi Yasuhisa; Suzuki Hiroshi; Sugiyama Yuichi
Quantitative evaluation of the function of small intestinal P-glycoprotein: comparative studies between in situ and in vitro.
Pharmaceutical research 2003;20(8):1163-9.
2003: Kikuchi Ryota; Kusuhara Hiroyuki; Sugiyama Daisuke; Sugiyama Yuichi
Contribution of organic anion transporter 3 (Slc22a8) to the elimination of p-aminohippuric acid and benzylpenicillin across the blood-brain barrier.
The Journal of pharmacology and experimental therapeutics 2003;306(1):51-8.
2003: Suzuki Michiko; Suzuki Hiroshi; Sugimoto Yoshikazu; Sugiyama Yuichi
ABCG2 transports sulfated conjugates of steroids and xenobiotics.
The Journal of biological chemistry 2003;278(25):22644-9.
2003: Hasegawa Maki; Kusuhara Hiroyuki; Endou Hitoshi; Sugiyama Yuichi
Contribution of organic anion transporters to the renal uptake of anionic compounds and nucleoside derivatives in rat.
The Journal of pharmacology and experimental therapeutics 2003;305(3):1087-97.
2003: Kusuhara Hiroyuki; He Zhonggui; Nagata Yoshinori; Nozaki Yoshitane; Ito Takashi; Masuda Hiroyuki; Meier Peter J; Abe Takaaki; Sugiyama Yuichi
Expression and functional involvement of organic anion transporting polypeptide subtype 3 (Slc21a7) in rat choroid plexus.
Pharmaceutical research 2003;20(5):720-7.
2003: Wang De-Sheng; Kusuhara Hiroyuki; Kato Yukio; Jonker Johan W; Schinkel Alfred H; Sugiyama Yuichi
Involvement of organic cation transporter 1 in the lactic acidosis caused by metformin.
Molecular pharmacology 2003;63(4):844-8.
2003: Fukuma Nobuko; Akimitsu Nobuyoshi; Hamamoto Hiroshi; Kusuhara Hiroyuki; Sugiyama Yuichi; Sekimizu Kazuhisa
A role of the Duffy antigen for the maintenance of plasma chemokine concentrations.
Biochemical and biophysical research communications 2003;303(1):137-9.
2003: Shitara Yoshihisa; Itoh Tomoo; Sato Hitoshi; Li Albert P; Sugiyama Yuichi
Inhibition of transporter-mediated hepatic uptake as a mechanism for drug-drug interaction between cerivastatin and cyclosporin A.
The Journal of pharmacology and experimental therapeutics 2003;304(2):610-6.
2003: Kato Motohiro; Chiba Koji; Hisaka Akihiro; Ishigami Michi; Kayama Makoto; Mizuno Naomi; Nagata Yoshinori; Takakuwa Susumu; Tsukamoto Yuko; Ueda Kaoru; Kusuhara Hiroyuki; Ito Kiyomi; Sugiyama Yuichi
The intestinal first-pass metabolism of substrates of CYP3A4 and P-glycoprotein-quantitative analysis based on information from the literature.
Drug metabolism and pharmacokinetics 2003;18(6):365-72.
2003: Kato Motohiro; Tachibana Tatsuhiko; Ito Kiyomi; Sugiyama Yuichi
Evaluation of methods for predicting drug-drug interactions by Monte Carlo simulation.
Drug metabolism and pharmacokinetics 2003;18(2):121-7.
2003: Shitara Yoshihisa; Li Albert P; Kato Yukio; Lu Chuang; Ito Kiyomi; Itoh Tomoo; Sugiyama Yuichi
Function of uptake transporters for taurocholate and estradiol 17beta-D-glucuronide in cryopreserved human hepatocytes.
Drug metabolism and pharmacokinetics 2003;18(1):33-41.
2003: Horikawa Masato; Kato Yukio; Tyson Charles A; Sugiyama Yuichi
Potential cholestatic activity of various therapeutic agents assessed by bile canalicular membrane vesicles isolated from rats and humans.
Drug metabolism and pharmacokinetics 2003;18(1):16-22.
2003: Kusuhara Hiroyuki; Terasaki Tetsuya; Sugiyama Yuichi
Brain efflux index method. Characterization of efflux transport across the blood-brain barrier.
Methods in molecular medicine 2003;89():219-31.
2002: Kato Yukio; Suzuki Hiroshi; Sugiyama Yuichi
Toxicological implications of hepatobiliary transporters.
Toxicology 2002;181-182():287-90.
2002: Akita Hidetaka; Suzuki Hiroshi; Sugiyama Yuichi
Sinusoidal efflux of taurocholate correlates with the hepatic expression level of Mrp3.
Biochemical and biophysical research communications 2002;299(5):681-7.
2002: Suzuki Hiroshi; Sugiyama Yuichi
Single nucleotide polymorphisms in multidrug resistance associated protein 2 (MRP2/ABCC2): its impact on drug disposition.
Advanced drug delivery reviews 2002;54(10):1311-31.
2002: Horikawa Masato; Kato Yukio; Sugiyama Yuichi
Reduced gastrointestinal toxicity following inhibition of the biliary excretion of irinotecan and its metabolites by probenecid in rats.
Pharmaceutical research 2002;19(9):1345-53.
2002: Wang De-Sheng; Jonker Johan W; Kato Yukio; Kusuhara Hiroyuki; Schinkel Alfred H; Sugiyama Yuichi
Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin.
The Journal of pharmacology and experimental therapeutics 2002;302(2):510-5.
2002: Kato Yukio; Kuge Kiyoka; Kusuhara Hiroyuki; Meier Peter J; Sugiyama Yuichi
Gender difference in the urinary excretion of organic anions in rats.
The Journal of pharmacology and experimental therapeutics 2002;302(2):483-9.
2002: Ji Bin; Ito Kousei; Suzuki Hiroshi; Sugiyama Yuichi; Horie Toshiharu
Multidrug resistance-associated protein2 (MRP2) plays an important role in the biliary excretion of glutathione conjugates of 4-hydroxynonenal.
Free radical biology & medicine 2002;33(3):370-8.
2002: Maeda Kazuya; Kato Yukio; Sugiyama Yuichi
pH-dependent receptor/ligand dissociation as a determining factor for intracellular sorting of ligands for epidermal growth factor receptors in rat hepatocytes.
Journal of controlled release : official journal of the Controlled Release Society 2002;82(1):71-82.
2002: Gotoh Yasumasa; Kato Yukio; Stieger Bruno; Meier Peter J; Sugiyama Yuichi
Gender difference in the Oatp1-mediated tubular reabsorption of estradiol 17beta-D-glucuronide in rats.
American journal of physiology. Endocrinology and metabolism 2002;282(6):E1245-54.
2002: Nagata Yoshinori; Kusuhara Hiroyuki; Endou Hitoshi; Sugiyama Yuichi
Expression and functional characterization of rat organic anion transporter 3 (rOat3) in the choroid plexus.
Molecular pharmacology 2002;61(5):982-8.
2002: Kakee Atsuyuki; Takanaga Hitomi; Hosoya Ken-ichi; Sugiyama Yuichi; Terasaki Tetsuya
In vivo evidence for brain-to-blood efflux transport of valproic acid across the blood-brain barrier.
Microvascular research 2002;63(2):233-8.
2002: Hasegawa Maki; Kusuhara Hiroyuki; Sugiyama Daisuke; Ito Kousei; Ueda Shirou; Endou Hitoshi; Sugiyama Yuichi
Functional involvement of rat organic anion transporter 3 (rOat3; Slc22a8) in the renal uptake of organic anions.
The Journal of pharmacology and experimental therapeutics 2002;300(3):746-53.
2002: Shitara Yoshihisa; Sugiyama Daisuke; Kusuhara Hiroyuki; Kato Yukio; Abe Takaaki; Meier Peter J; Itoh Tomoo; Sugiyama Yuichi
Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport.
Pharmaceutical research 2002;19(2):147-53.
2002: Sugiyama Daisuke; Kusuhara Hiroyuki; Shitara Yoshihisa; Abe Takaaki; Sugiyama Yuichi
Effect of 17 beta-estradiol-D-17 beta-glucuronide on the rat organic anion transporting polypeptide 2-mediated transport differs depending on substrates.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(2):220-3.
2002: Sasaki Makoto; Suzuki Hiroshi; Ito Kousei; Abe Takaaki; Sugiyama Yuichi
Transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II cell monolayer expressing both human organic anion-transporting polypeptide (OATP2/SLC21A6) and Multidrug resistance-associated protein 2 (MRP2/ABCC2).
The Journal of biological chemistry 2002;277(8):6497-503.
2002: Akita Hidetaka; Suzuki Hiroshi; Hirohashi Tomoko; Takikawa Hajime; Sugiyama Yuichi
Transport activity of human MRP3 expressed in Sf9 cells: comparative studies with rat MRP3.
Pharmaceutical research 2002;19(1):34-41.
2002: Kusuhara Hiroyuki; Sugiyama Yuichi
Role of transporters in the tissue-selective distribution and elimination of drugs: transporters in the liver, small intestine, brain and kidney.
Journal of controlled release : official journal of the Controlled Release Society 2002;78(1-3):43-54.
2002: Horikawa Masato; Kato Yukio; Tyson Charles A; Sugiyama Yuichi
The potential for an interaction between MRP2 (ABCC2) and various therapeutic agents: probenecid as a candidate inhibitor of the biliary excretion of irinotecan metabolites.
Drug metabolism and pharmacokinetics 2002;17(1):23-33.
2002: Ito Kiyomi; Chiba Koji; Horikawa Masato; Ishigami Michi; Mizuno Naomi; Aoki Jun; Gotoh Yasumasa; Iwatsubo Takafumi; Kanamitsu Shin-ichi; Kato Motohiro; Kawahara Iichiro; Niinuma Kayoko; Nishino Akiko; Sato Norihito; Tsukamoto Yuko; Ueda Kaoru; Itoh Tomoo; Sugiyama Yuichi
Which concentration of the inhibitor should be used to predict in vivo drug interactions from in vitro data?
AAPS pharmSci 2002;4(4):E25.
2001: Adachi Y; Suzuki H; Sugiyama Y
Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein.
Pharmaceutical research 2001;18(12):1660-8.
2001: Yamamoto Y; Nagasaki Y; Kato Y; Sugiyama Y; Kataoka K
Long-circulating poly(ethylene glycol)-poly(D,L-lactide) block copolymer micelles with modulated surface charge.
Journal of controlled release : official journal of the Controlled Release Society 2001;77(1-2):27-38.
2001: Shirota K; Kato Y; Suzuki K; Sugiyama Y
Characterization of novel kidney-specific delivery system using an alkylglucoside vector.
The Journal of pharmacology and experimental therapeutics 2001;299(2):459-67.
2001: Kakee A; Takanaga H; Terasaki T; Naito M; Tsuruo T; Sugiyama Y
Efflux of a suppressive neurotransmitter, GABA, across the blood-brain barrier.
Journal of neurochemistry 2001;79(1):110-8.
2001: Ito K; Suzuki H; Sugiyama Y
Single amino acid substitution of rat MRP2 results in acquired transport activity for taurocholate.
American journal of physiology. Gastrointestinal and liver physiology 2001;281(4):G1034-43.
2001: Morita N; Kusuhara H; Sekine T; Endou H; Sugiyama Y
Functional characterization of rat organic anion transporter 2 in LLC-PK1 cells.
The Journal of pharmacology and experimental therapeutics 2001;298(3):1179-84.
2001: Mizuno N; Kato Y; Iwamoto M; Urae A; Amamoto T; Niwa T; Sugiyama Y
Kinetic analysis of the disposition of insulin-like growth factor 1 in healthy volunteers.
Pharmaceutical research 2001;18(8):1203-9.
2001: Akita H; Suzuki H; Sugiyama Y
Sinusoidal efflux of taurocholate is enhanced in Mrp2-deficient rat liver.
Pharmaceutical research 2001;18(8):1119-25.
2001: Nishiyama N; Kato Y; Sugiyama Y; Kataoka K
Cisplatin-loaded polymer-metal complex micelle with time-modulated decaying property as a novel drug delivery system.
Pharmaceutical research 2001;18(7):1035-41.
2001: Sugiyama D; Kusuhara H; Shitara Y; Abe T; Meier P J; Sekine T; Endou H; Suzuki H; Sugiyama Y
Characterization of the efflux transport of 17beta-estradiol-D-17beta-glucuronide from the brain across the blood-brain barrier.
The Journal of pharmacology and experimental therapeutics 2001;298(1):316-22.
2001: Ueda K; Kato Y; Komatsu K; Sugiyama Y
Inhibition of biliary excretion of methotrexate by probenecid in rats: quantitative prediction of interaction from in vitro data.
The Journal of pharmacology and experimental therapeutics 2001;297(3):1036-43.
2001: Han Y H; Kato Y; Haramura M; Ohta M; Matsuoka H; Sugiyama Y
Physicochemical parameters responsible for the affinity of methotrexate analogs for rat canalicular multispecific organic anion transporter (cMOAT/MRP2).
Pharmaceutical research 2001;18(5):579-86.
2001: Ito K; Suzuki H; Sugiyama Y
Charged amino acids in the transmembrane domains are involved in the determination of the substrate specificity of rat Mrp2.
Molecular pharmacology 2001;59(5):1077-85.
2001: Han Y H; Kato Y; Watanabe Y; Terao K; Asoh Y; Sugiyama Y
Carrier-mediated hepatobiliary transport of a novel antifolate, N-[4-[(2,4-dianninopteridine-6-yl)methyl]-3,4-dihydro-2H-1,4-benzothiazin-7-yl]carbonyl-L-homoglutamic acid, in rats.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(4 Pt 1):394-400.
2001: Hirota N; Ito K; Iwatsubo T; Green C E; Tyson C A; Shimada N; Suzuki H; Sugiyama Y
In vitro/in vivo scaling of alprazolam metabolism by CYP3A4 and CYP3A5 in humans.
Biopharmaceutics & drug disposition 2001;22(2):53-71.
2001: Shirota K; Kato Y; Irimura T; Kondo H; Sugiyama Y
Anti-metastatic effect of the sialyl Lewis-X analog GSC-150 on the human colon carcinoma derived cell line KM12-HX in the mouse.
Biological & pharmaceutical bulletin 2001;24(3):316-9.
2001: Akita H; Suzuki H; Ito K; Kinoshita S; Sato N; Takikawa H; Sugiyama Y
Characterization of bile acid transport mediated by multidrug resistance associated protein 2 and bile salt export pump.
Biochimica et biophysica acta 2001;1511(1):7-16.
2000: Suzuki H; Sugiyama Y
Role of metabolic enzymes and efflux transporters in the absorption of drugs from the small intestine.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2000;12(1):3-12.
2000: Kawahara I; Kato Y; Suzuki H; Achira M; Ito K; Crespi C L; Sugiyama Y
Selective inhibition of human cytochrome P450 3A4 by N-[2(R)-hydroxy-1(S)-indanyl]-5-[2(S)-(1, 1-dimethylethylaminocarbonyl)-4-[(furo[2, 3-b]pyridin-5-yl)methyl]piperazin-1-yl]-4(S)-hydroxy-2(R)-phenylmethy lpentanamide and P-glycoprotein by valspodar in gene transfectant systems.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(10):1238-43.
2000: Nishino A; Kato Y; Igarashi T; Sugiyama Y
Both cMOAT/MRP2 and another unknown transporter(s) are responsible for the biliary excretion of glucuronide conjugate of the nonpeptide angiotensin II antagonist, telmisaltan.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(10):1146-8.
2000: Liu K X; Kato Y; Kaku T I; Santa T; Imai K; Yagi A; Ishizu T; Sugiyama Y
Hydroxyprolylserine derivatives JBP923 and JBP485 exhibit the antihepatitis activities after gastrointestinal absorption in rats.
The Journal of pharmacology and experimental therapeutics 2000;294(2):510-5.
2000: Morikawa A; Goto Y; Suzuki H; Hirohashi T; Sugiyama Y
Biliary excretion of 17beta-estradiol 17beta-D-glucuronide is predominantly mediated by cMOAT/MRP2.
Pharmaceutical research 2000;17(5):546-52.
2000: Kouzuki H; Suzuki H; Sugiyama Y
Pharmacokinetic study of the hepatobiliary transport of indomethacin.
Pharmaceutical research 2000;17(4):432-8.
2000: Kanamitsu S; Ito K; Green C E; Tyson C A; Shimada N; Sugiyama Y
Prediction of in vivo interaction between triazolam and erythromycin based on in vitro studies using human liver microsomes and recombinant human CYP3A4.
Pharmaceutical research 2000;17(4):419-26.
2000: Takada T; Suzuki H; Sugiyama Y
Characterization of 5'-flanking region of human MRP3.
Biochemical and biophysical research communications 2000;270(3):728-32.
2000: Komatsu K; Ito K; Nakajima Y; Kanamitsu S i; Imaoka S; Funae Y; Green C E; Tyson C A; Shimada N; Sugiyama Y
Prediction of in vivo drug-drug interactions between tolbutamide and various sulfonamides in humans based on in vitro experiments.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(4):475-81.
2000: Kanamitsu S I; Ito K; Okuda H; Ogura K; Watabe T; Muro K; Sugiyama Y
Prediction of in vivo drug-drug interactions based on mechanism-based inhibition from in vitro data: inhibition of 5-fluorouracil metabolism by (E)-5-(2-Bromovinyl)uracil.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(4):467-74.
2000: Kanamitsu S; Ito K; Sugiyama Y
Quantitative prediction of in vivo drug-drug interactions from in vitro data based on physiological pharmacokinetics: use of maximum unbound concentration of inhibitor at the inlet to the liver.
Pharmaceutical research 2000;17(3):336-43.
2000: Ogawa K; Suzuki H; Hirohashi T; Ishikawa T; Meier P J; Hirose K; Akizawa T; Yoshioka M; Sugiyama Y
Characterization of inducible nature of MRP3 in rat liver.
American journal of physiology. Gastrointestinal and liver physiology 2000;278(3):G438-46.
2000: Kouzuki H; Suzuki H; Stieger B; Meier P J; Sugiyama Y
Characterization of the transport properties of organic anion transporting polypeptide 1 (oatp1) and Na(+)/taurocholate cotransporting polypeptide (Ntcp): comparative studies on the inhibitory effect of their possible substrates in hepatocytes and cDNA-transfected COS-7 cells.
The Journal of pharmacology and experimental therapeutics 2000;292(2):505-11.
2000: Watanabe Y; Suzuki H; Suzuki K; Ando T; Nakabayashi S; Sugiyama Y
Detection of the membrane protein recognized by the kidney-specific alkylglucoside vector.
Pharmaceutical research 2000;17(1):49-54.
2000: Hirohashi T; Suzuki H; Takikawa H; Sugiyama Y
ATP-dependent transport of bile salts by rat multidrug resistance-associated protein 3 (Mrp3).
The Journal of biological chemistry 2000;275(4):2905-10.
2000: Gotoh Y; Suzuki H; Kinoshita S; Hirohashi T; Kato Y; Sugiyama Y
Involvement of an organic anion transporter (canalicular multispecific organic anion transporter/multidrug resistance-associated protein 2) in gastrointestinal secretion of glutathione conjugates in rats.
The Journal of pharmacology and experimental therapeutics 2000;292(1):433-9.
2000: Hirohashi T; Suzuki H; Chu X Y; Tamai I; Tsuji A; Sugiyama Y
Function and expression of multidrug resistance-associated protein family in human colon adenocarcinoma cells (Caco-2).
The Journal of pharmacology and experimental therapeutics 2000;292(1):265-70.
2000: Suzuki H; Sugiyama Y
Transport of drugs across the hepatic sinusoidal membrane: sinusoidal drug influx and efflux in the liver.
Seminars in liver disease 2000;20(3):251-63.
1999: Han Y H; Kato Y; Sugiyama Y
Binding and transport of methotrexate and its derivative, MX-68, across the brush-border membrane in rat kidney.
Biopharmaceutics & drug disposition 1999;20(8):361-7.
1999: Sugiyama Y; Kusuhara H; Suzuki H
Kinetic and biochemical analysis of carrier-mediated efflux of drugs through the blood-brain and blood-cerebrospinal fluid barriers: importance in the drug delivery to the brain.
Journal of controlled release : official journal of the Controlled Release Society 1999;62(1-2):179-86.
1999: Han Y H; Kato Y; Sugiyama Y
Nonlinear disposition kinetics of a novel antifolate, MX-68, in rats.
The Journal of pharmacology and experimental therapeutics 1999;291(1):204-12.
1999: Ishizuka H; Konno K; Shiina T; Naganuma H; Nishimura K; Ito K; Suzuki H; Sugiyama Y
Species differences in the transport activity for organic anions across the bile canalicular membrane.
The Journal of pharmacology and experimental therapeutics 1999;290(3):1324-30.
1999: Akhteruzzaman S; Kato Y; Kouzuki H; Suzuki H; Hisaka A; Stieger B; Meier P J; Sugiyama Y
Carrier-mediated hepatic uptake of peptidic endothelin antagonists in rats.
The Journal of pharmacology and experimental therapeutics 1999;290(3):1107-15.
1999: Kato M; Kato Y; Nakamura T; Sugiyama Y
Efficient extraction by the liver governs overall elimination of hepatocyte growth factor in rats.
The Journal of pharmacology and experimental therapeutics 1999;290(1):373-9.
1999: Nishino J; Suzuki H; Sugiyama D; Kitazawa T; Ito K; Hanano M; Sugiyama Y
Transepithelial transport of organic anions across the choroid plexus: possible involvement of organic anion transporter and multidrug resistance-associated protein.
The Journal of pharmacology and experimental therapeutics 1999;290(1):289-94.
1999: Tokui T; Nakai D; Nakagomi R; Yawo H; Abe T; Sugiyama Y
Pravastatin, an HMG-CoA reductase inhibitor, is transported by rat organic anion transporting polypeptide, oatp2.
Pharmaceutical research 1999;16(6):904-8.
1999: Song S; Suzuki H; Kawai R; Sugiyama Y
Effect of PSC 833, a P-glycoprotein modulator, on the disposition of vincristine and digoxin in rats.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(6):689-94.
1999: Kino I; Kato Y; Lin J H; Sugiyama Y
Renal handling of biphosphonate alendronate in rats.
Biopharmaceutics & drug disposition 1999;20(4):193-8.
1999: Niinuma K; Kato Y; Suzuki H; Tyson C A; Weizer V; Dabbs J E; Froehlich R; Green C E; Sugiyama Y
Primary active transport of organic anions on bile canalicular membrane in humans.
The American journal of physiology 1999;276(5 Pt 1):G1153-64.
1999: Kato M; Kato Y; Sugiyama Y
Mechanism of the upregulation of erythropoietin-induced uptake clearance by the spleen.
The American journal of physiology 1999;276(5 Pt 1):E887-95.
1999: Hirohashi T; Suzuki H; Sugiyama Y
Characterization of the transport properties of cloned rat multidrug resistance-associated protein 3 (MRP3).
The Journal of biological chemistry 1999;274(21):15181-5.
1999: Kusuhara H; Sekine T; Utsunomiya-Tate N; Tsuda M; Kojima R; Cha S H; Sugiyama Y; Kanai Y; Endou H
Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain.
The Journal of biological chemistry 1999;274(19):13675-80.
1999: Ueda K; Suzuki H; Akiyama S; Sugiyama Y
Differences in substrate specificity among glutathione conjugates (GS-X) pump family members: comparison between multidrug resistance-associated protein and a novel transporter expressed on a cisplatin-resistant cell line (KCP-4).
Japanese journal of cancer research : Gann 1999;90(4):439-47.
1999: Sasabe H; Kato Y; Terasaki T; Tsuji A; Sugiyama Y
Differences in the hepatobiliary transport of two quinolone antibiotics, grepafloxacin and lomefloxacin, in the rat.
Biopharmaceutics & drug disposition 1999;20(3):151-8.
1999: Chu X Y; Kato Y; Sugiyama Y
Possible involvement of P-glycoprotein in biliary excretion of CPT-11 in rats.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(4):440-1.
1999: Han Y H; Kato Y; Kusuhara H; Suzuki H; Shimoda M; Kokue E; Sugiyama Y
Kinetic profile of overall elimination of 5-methyltetrahydropteroylglutamate in rats.
The American journal of physiology 1999;276(3 Pt 1):E580-7.
1999: Ito K; Kusuhara H; Sugiyama Y
Effects of intestinal CYP3A4 and P-glycoprotein on oral drug absorption--theoretical approach.
Pharmaceutical research 1999;16(2):225-31.
1999: Chu X Y; Suzuki H; Ueda K; Kato Y; Akiyama S; Sugiyama Y
Active efflux of CPT-11 and its metabolites in human KB-derived cell lines.
The Journal of pharmacology and experimental therapeutics 1999;288(2):735-41.
1999: Kouzuki H; Suzuki H; Ito K; Ohashi R; Sugiyama Y
Contribution of organic anion transporting polypeptide to uptake of its possible substrates into rat hepatocytes.
The Journal of pharmacology and experimental therapeutics 1999;288(2):627-34.
1999: Akhteruzzaman S; Kato Y; Hisaka A; Sugiyama Y
Primary active transport of peptidic endothelin antagonists by rat hepatic canalicular membrane.
The Journal of pharmacology and experimental therapeutics 1999;288(2):575-81.
1999: Kato Y; Akhteruzzaman S; Hisaka A; Sugiyama Y
Hepatobiliary transport governs overall elimination of peptidic endothelin antagonists in rats.
The Journal of pharmacology and experimental therapeutics 1999;288(2):568-74.
1999: Homma M; Suzuki H; Kusuhara H; Naito M; Tsuruo T; Sugiyama Y
High-affinity efflux transport system for glutathione conjugates on the luminal membrane of a mouse brain capillary endothelial cell line (MBEC4).
The Journal of pharmacology and experimental therapeutics 1999;288(1):198-203.
1999: Achira M; Suzuki H; Ito K; Sugiyama Y
Comparative studies to determine the selective inhibitors for P-glycoprotein and cytochrome P4503A4.
AAPS pharmSci 1999;1(4):E18.
1999: Suzuki H; Sugiyama Y
Transporters for bile acids and organic anions.
Pharmaceutical biotechnology 1999;12():387-439.
1998: Kinoshita S; Suzuki H; Ito K; Kume K; Shimizu T; Sugiyama Y
Transfected rat cMOAT is functionally expressed on the apical membrane in Madin-Darby canine kidney (MDCK) cells.
Pharmaceutical research 1998;15(12):1851-6.
1998: Song S; Suzuki H; Terasaki T; Lemaire M; Sugiyama Y
Modulation of the tumor disposition of vinca alkaloids by PSC 833 in vitro and in vivo.
The Journal of pharmacology and experimental therapeutics 1998;287(3):963-8.
1998: Chu X Y; Kato Y; Ueda K; Suzuki H; Niinuma K; Tyson C A; Weizer V; Dabbs J E; Froehlich R; Green C E; Sugiyama Y
Biliary excretion mechanism of CPT-11 and its metabolites in humans: involvement of primary active transporters.
Cancer research 1998;58(22):5137-43.
1998: Liu K X; Kato Y; Kino I; Nakamura T; Sugiyama Y
Ligand-induced downregulation of receptor-mediated clearance of hepatocyte growth factor in rats.
The American journal of physiology 1998;275(5 Pt 1):E835-42.
1998: Song S; Suzuki H; Kawai R; Tanaka C; Akasaka I; Sugiyama Y
Dose-dependent effects of PSC 833 on its tissue distribution and on the biliary excretion of endogenous substrates in rats.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(11):1128-33.
1998: Sugiyama Y; Ito K
Future prospects for toxicokinetics: prediction of drug disposition and adverse effects in humans from in vitro measurements of drug metabolism, transport and binding.
The Journal of toxicological sciences 1998;23 Suppl 4():647-52.
1998: Shitara Y; Kato Y; Sugiyama Y
Effect of brefeldin A and lysosomotropic reagents on intracellular trafficking of epidermal growth factor and transferrin in Madin-Darby canine kidney epithelial cells.
Journal of controlled release : official journal of the Controlled Release Society 1998;55(1):35-43.
1998: Ishizuka H; Konno K; Naganuma H; Nishimura K; Kouzuki H; Suzuki H; Stieger B; Meier P J; Sugiyama Y
Transport of temocaprilat into rat hepatocytes: role of organic anion transporting polypeptide.
The Journal of pharmacology and experimental therapeutics 1998;287(1):37-42.
1998: Kusuhara H; Han Y H; Shimoda M; Kokue E; Suzuki H; Sugiyama Y
Reduced folate derivatives are endogenous substrates for cMOAT in rats.
The American journal of physiology 1998;275(4 Pt 1):G789-96.
1998: Ito K; Iwatsubo T; Kanamitsu S; Ueda K; Suzuki H; Sugiyama Y
Prediction of pharmacokinetic alterations caused by drug-drug interactions: metabolic interaction in the liver.
Pharmacological reviews 1998;50(3):387-412.
1998: Kusuhara H; Suzuki H; Sugiyama Y
The role of P-glycoprotein and canalicular multispecific organic anion transporter in the hepatobiliary excretion of drugs.
Journal of pharmaceutical sciences 1998;87(9):1025-40.
1998: Yamada T; Kato Y; Kusuhara H; Lemaire M; Sugiyama Y
Characterization of the transport of a cationic octapeptide, octreotide, in rat bile canalicular membrane: possible involvement of P-glycoprotein.
Biological & pharmaceutical bulletin 1998;21(8):874-8.
1998: Kiuchi Y; Suzuki H; Hirohashi T; Tyson C A; Sugiyama Y
cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3).
FEBS letters 1998;433(1-2):149-52.
1998: Kouzuki H; Suzuki H; Ito K; Ohashi R; Sugiyama Y
Contribution of sodium taurocholate co-transporting polypeptide to the uptake of its possible substrates into rat hepatocytes.
The Journal of pharmacology and experimental therapeutics 1998;286(2):1043-50.
1998: Kitazawa T; Terasaki T; Suzuki H; Kakee A; Sugiyama Y
Efflux of taurocholic acid across the blood-brain barrier: interaction with cyclic peptides.
The Journal of pharmacology and experimental therapeutics 1998;286(2):890-5.
1998: Kusuhara H; Suzuki H; Naito M; Tsuruo T; Sugiyama Y
Characterization of efflux transport of organic anions in a mouse brain capillary endothelial cell line.
The Journal of pharmacology and experimental therapeutics 1998;285(3):1260-5.
1998: Mizuno N; Kato Y; Shirota K; Izumi Y; Irimura T; Harashima H; Kiwada H; Motoji N; Shigematsu A; Sugiyama Y
Mechanism of initial distribution of blood-borne colon carcinoma cells in the liver.
Journal of hepatology 1998;28(5):878-85.
1998: Mizuno N; Kato Y; Izumi Y; Irimura T; Sugiyama Y
Importance of hepatic first-pass removal in metastasis of colon carcinoma cells.
Journal of hepatology 1998;28(5):865-77.
1998: Sasabe H; Tsuji A; Sugiyama Y
Carrier-mediated mechanism for the biliary excretion of the quinolone antibiotic grepafloxacin and its glucuronide in rats.
The Journal of pharmacology and experimental therapeutics 1998;284(3):1033-9.
1998: Imawaka H; Sugiyama Y
Kinetic study of the hepatobiliary transport of a new prostaglandin receptor agonist.
The Journal of pharmacology and experimental therapeutics 1998;284(3):949-57.
1998: Sasabe H; Kato Y; Tsuji A; Sugiyama Y
Stereoselective hepatobiliary transport of the quinolone antibiotic grepafloxacin and its glucuronide in the rat.
The Journal of pharmacology and experimental therapeutics 1998;284(2):661-8.
1998: Liu K X; Kato Y; Kaku T; Sugiyama Y
Human placental extract stimulates liver regeneration in rats.
Biological & pharmaceutical bulletin 1998;21(1):44-9.
1998: Liu K X; Kato Y; Kaku T I; Matsumoto K; Nakamura T; Sugiyama Y
Protamine enhances the proliferative activity of hepatocyte growth factor in rats.
The American journal of physiology 1998;274(1 Pt 1):G21-8.
1998: Ito K; Suzuki H; Hirohashi T; Kume K; Shimizu T; Sugiyama Y
Functional analysis of a canalicular multispecific organic anion transporter cloned from rat liver.
The Journal of biological chemistry 1998;273(3):1684-8.
1998: Suzuki H; Sugiyama Y
Excretion of GSSG and glutathione conjugates mediated by MRP1 and cMOAT/MRP2.
Seminars in liver disease 1998;18(4):359-76.
1998: Sugiyama Y; Kato Y; Chu X
Multiplicity of biliary excretion mechanisms for the camptothecin derivative irinotecan (CPT-11), its metabolite SN-38, and its glucuronide: role of canalicular multispecific organic anion transporter and P-glycoprotein.
Cancer chemotherapy and pharmacology 1998;42 Suppl():S44-9.
1998: Ito K; Iwatsubo T; Kanamitsu S; Nakajima Y; Sugiyama Y
Quantitative prediction of in vivo drug clearance and drug interactions from in vitro data on metabolism, together with binding and transport.
Annual review of pharmacology and toxicology 1998;38():461-99.
1997: Liu K X; Kato Y; Kato M; Kaku T I; Nakamura T; Sugiyama Y
Existence of two nonlinear elimination mechanisms for hepatocyte growth factor in rats.
The American journal of physiology 1997;273(5 Pt 1):E891-7.
1997: Kusuhara H; Suzuki H; Terasaki T; Kakee A; Lemaire M; Sugiyama Y
P-Glycoprotein mediates the efflux of quinidine across the blood-brain barrier.
The Journal of pharmacology and experimental therapeutics 1997;283(2):574-80.
1997: Mano Y; Suzuki H; Terasaki T; Iwahashi T; Ono K; Naito M; Tsuruo T; Sugiyama Y
Kinetic analysis of the disposition of MRK16, an anti-P-glycoprotein monoclonal antibody, in tumors: comparison between in vitro and in vivo disposition.
The Journal of pharmacology and experimental therapeutics 1997;283(1):391-401.
1997: Ooie T; Terasaki T; Suzuki H; Sugiyama Y
Kinetic evidence for active efflux transport across the blood-brain barrier of quinolone antibiotics.
The Journal of pharmacology and experimental therapeutics 1997;283(1):293-304.
1997: Takasawa K; Suzuki H; Sugiyama Y
Transport properties of 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine in the rat choroid plexus.
Biopharmaceutics & drug disposition 1997;18(7):611-22.
1997: Suzuki H; Sugiyama Y
[Primary active transporter responsible for the biliary excretion of xenobiotics]
Seikagaku. The Journal of Japanese Biochemical Society 1997;69(9):1098-101.
1997: Kozu A; Kato Y; Shitara Y; Hanano M; Sugiyama Y
Kinetic analysis of transcytosis of epidermal growth factor in Madin-Darby canine kidney epithelial cells.
Pharmaceutical research 1997;14(9):1228-35.
1997: Takasawa K; Terasaki T; Suzuki H; Ooie T; Sugiyama Y
Distributed model analysis of 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine distribution in brain tissue and cerebrospinal fluid.
The Journal of pharmacology and experimental therapeutics 1997;282(3):1509-17.
1997: Niinuma K; Takenaka O; Horie T; Kobayashi K; Kato Y; Suzuki H; Sugiyama Y
Kinetic analysis of the primary active transport of conjugated metabolites across the bile canalicular membrane: comparative study of S-(2,4-dinitrophenyl)-glutathione and 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)benzothiazole glucuronide.
The Journal of pharmacology and experimental therapeutics 1997;282(2):866-72.
1997: Ooie T; Terasaki T; Suzuki H; Sugiyama Y
Quantitative brain microdialysis study on the mechanism of quinolones distribution in the central nervous system.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(7):784-9.
1997: Sasabe H; Terasaki T; Tsuji A; Sugiyama Y
Carrier-mediated hepatic uptake of quinolone antibiotics in the rat.
The Journal of pharmacology and experimental therapeutics 1997;282(1):162-71.
1997: Suzuki H; Sugiyama Y
[Role of transporters in the detoxification of xenobiotics: recent advances in the study of cMOAT/MRP]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1997;42(8):1273-84.
1997: Shin H C; Kato Y; Yamada T; Niinuma K; Hisaka A; Sugiyama Y
Hepatobiliary transport mechanism for the cyclopentapeptide endothelin antagonist BQ-123.
The American journal of physiology 1997;272(5 Pt 1):G979-86.
1997: Izumi T; Enomoto S; Hoshiyama K; Sasahara K; Sugiyama Y
Pharmacokinetic stereoselectivity of troglitazone, an antidiabetic agent, in the KK mouse.
Biopharmaceutics & drug disposition 1997;18(4):305-24.
1997: Chu X Y; Kato Y; Sugiyama Y
Multiplicity of biliary excretion mechanisms for irinotecan, CPT-11, and its metabolites in rats.
Cancer research 1997;57(10):1934-8.
1997: Kusuhara H; Suzuki H; Sugiyama Y
[The role of P-glycoprotein in the liver]
Nippon rinsho. Japanese journal of clinical medicine 1997;55(5):1069-76.
1997: Yamada T; Niinuma K; Lemaire M; Terasaki T; Sugiyama Y
Carrier-mediated hepatic uptake of the cationic cyclopeptide, octreotide, in rats. Comparison between in vivo and in vitro.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(5):536-43.
1997: Izumi T; Hoshiyama K; Enomoto S; Sasahara K; Sugiyama Y
Determination of protein binding of troglitazone stereoisomers by fluorometric titration.
Biopharmaceutics & drug disposition 1997;18(3):241-57.
1997: Takasawa K; Terasaki T; Suzuki H; Sugiyama Y
In vivo evidence for carrier-mediated efflux transport of 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine across the blood-brain barrier via a probenecid-sensitive transport system.
The Journal of pharmacology and experimental therapeutics 1997;281(1):369-75.
1997: Chu X Y; Kato Y; Niinuma K; Sudo K I; Hakusui H; Sugiyama Y
Multispecific organic anion transporter is responsible for the biliary excretion of the camptothecin derivative irinotecan and its metabolites in rats.
The Journal of pharmacology and experimental therapeutics 1997;281(1):304-14.
1997: Izumi T; Hosiyama K; Enomoto S; Sasahara K; Sugiyama Y
Pharmacokinetics of troglitazone, an antidiabetic agent: prediction of in vivo stereoselective sulfation and glucuronidation from in vitro data.
The Journal of pharmacology and experimental therapeutics 1997;280(3):1392-400.
1997: Ishizuka H; Konno K; Naganuma H; Sasahara K; Kawahara Y; Niinuma K; Suzuki H; Sugiyama Y
Temocaprilat, a novel angiotensin-converting enzyme inhibitor, is excreted in bile via an ATP-dependent active transporter (cMOAT) that is deficient in Eisai hyperbilirubinemic mutant rats (EHBR).
The Journal of pharmacology and experimental therapeutics 1997;280(3):1304-11.
1997: Hamada T; Kato Y; Terasaki T; Sugiyama Y
Cell density-dependent mitogenic effect and -independent cellular handling of epidermal growth factor in primary cultured rat hepatocytes.
Journal of hepatology 1997;26(2):353-60.
1997: Hirohashi T; Terasaki T; Shigetoshi M; Sugiyama Y
In vivo and in vitro evidence for nonrestricted transport of 2',7'-bis(2-carboxyethyl)-5(6)-carboxyfluorescein tetraacetoxymethyl ester at the blood-brain barrier.
The Journal of pharmacology and experimental therapeutics 1997;280(2):813-9.
1997: Ito K; Suzuki H; Hirohashi T; Kume K; Shimizu T; Sugiyama Y
Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR.
The American journal of physiology 1997;272(1 Pt 1):G16-22.
1996: Sugiyama Y; Ito K; Tsuda M; Horii I
Future prospects for toxicokinetics: its ability to predict drug adverse events in humans.
The Journal of toxicological sciences 1996;21(5):511-6.
1996: Sugiyama Y; Iwatsubo T; Ueda K; Ito K
Strategic proposals for avoiding toxic interactions with drugs for clinical use during development and after marketing of a new drug: pharmacokinetic consideration.
The Journal of toxicological sciences 1996;21(5):309-16.
1996: Yamazaki M; Tokui T; Ishigami M; Sugiyama Y
Tissue-selective uptake of pravastatin in rats: contribution of a specific carrier-mediated uptake system.
Biopharmaceutics & drug disposition 1996;17(9):775-89.
1996: Yamada T; Niinuma K; Lemaire M; Terasaki T; Sugiyama Y
Mechanism of the tissue distribution and biliary excretion of the cyclic peptide octreotide.
The Journal of pharmacology and experimental therapeutics 1996;279(3):1357-64.
1996: Yamazaki M; Kobayashi K; Sugiyama Y
Primary active transport of pravastatin across the liver canalicular membrane in normal and mutant Eisai hyperbilirubinaemic rats.
Biopharmaceutics & drug disposition 1996;17(8):645-59.
1996: Yamazaki M; Kobayashi K; Sugiyama Y
Primary active transport of pravastatin across the liver canalicular membrane in normal and mutant Eisai hyperbilirubinemic rats.
Biopharmaceutics & drug disposition 1996;17(7):607-21.
1996: Nakai D; Seita T; Terasaki T; Iwasa S; Shoji Y; Mizushima Y; Sugiyama Y
Cellular uptake mechanism for oligonucleotides: involvement of endocytosis in the uptake of phosphodiester oligonucleotides by a human colorectal adenocarcinoma cell line, HCT-15.
The Journal of pharmacology and experimental therapeutics 1996;278(3):1362-72.
1996: Shin H C; Kato Y; Shitara Y; Yamada T; Nakamura T; Hisaka A; Sugiyama Y
The endothelin receptor is a major determinant for the nonlinear tissue distribution of the endothelin antagonist BQ-123.
The Journal of pharmacology and experimental therapeutics 1996;278(2):607-13.
1996: Ooie T; Suzuki H; Terasaki T; Sugiyama Y
Comparative distribution of quinolone antibiotics in cerebrospinal fluid and brain in rats and dogs.
The Journal of pharmacology and experimental therapeutics 1996;278(2):590-6.
1996: Ooie T; Suzuki H; Terasaki T; Sugiyama Y
Kinetics of quinolone antibiotics in rats: efflux from cerebrospinal fluid to the circulation.
Pharmaceutical research 1996;13(7):1065-8.
1996: Izumi T; Enomoto S; Hosiyama K; Sasahara K; Shibukawa A; Nakagawa T; Sugiyama Y
Prediction of the human pharmacokinetics of troglitazone, a new and extensively metabolized antidiabetic agent, after oral administration, with an animal scale-up approach.
The Journal of pharmacology and experimental therapeutics 1996;277(3):1630-41.
1996: Iwatsubo T; Hirota N; Ooie T; Suzuki H; Sugiyama Y
Prediction of in vivo drug disposition from in vitro data based on physiological pharmacokinetics.
Biopharmaceutics & drug disposition 1996;17(4):273-310.
1996: Ooie T; Suzuki H; Terasaki T; Sugiyama Y
Characterization of the transport properties of a quinolone antibiotic, fleroxacin, in rat choroid plexus.
Pharmaceutical research 1996;13(4):523-7.
1996: Niinuma K; Suzuki H; Yamazaki M; Sugiyama Y
[Preparation of plasma membrane and the analysis of transport kinetics and driving forces]
Nippon rinsho. Japanese journal of clinical medicine 1996;54(3):692-703.
1995: Suzuki H; Iwatsubo T; Sugiyama Y
Applications and prospects for physiologically based pharmacokinetic (PB-PK) models involving pharmaceutical agents.
Toxicology letters 1995;82-83():349-55.
1995: Ishigami M; Tokui T; Komai T; Tsukahara K; Yamazaki M; Sugiyama Y
Evaluation of the uptake of pravastatin by perfused rat liver and primary cultured rat hepatocytes.
Pharmaceutical research 1995;12(11):1741-5.
1995: Liu K X; Kato Y; Terasaki T; Aoki S; Okumura K; Nakamura T; Sugiyama Y
Contribution of parenchymal and non-parenchymal liver cells to the clearance of hepatocyte growth factor from the circulation in rats.
Pharmaceutical research 1995;12(11):1737-40.
1995: Liu K X; Kato Y; Terasaki T; Nakamura T; Sugiyama Y
Change in hepatic handling of hepatocyte growth factor during liver regeneration in rats.
The American journal of physiology 1995;269(5 Pt 1):G745-53.
1995: Watanabe T; Suzuki H; Sawada Y; Naito M; Tsuruo T; Inaba M; Hanano M; Sugiyama Y
Induction of hepatic P-glycoprotein enhances biliary excretion of vincristine in rats.
Journal of hepatology 1995;23(4):440-8.
1994: Kato Y; Liu K X; Nakamura T; Sugiyama Y
Heparin-hepatocyte growth factor complex with low plasma clearance and retained hepatocyte proliferating activity.
Hepatology (Baltimore, Md.) 1994;20(2):417-24.
1994: Ogawa M; Suzuki H; Sawada Y; Hanano M; Sugiyama Y
Kinetics of active efflux via choroid plexus of beta-lactam antibiotics from the CSF into the circulation.
The American journal of physiology 1994;266(2 Pt 2):R392-9.
1994: Ichikawa M; Kato Y; Miyauchi S; Sawada Y; Iga T; Fuwa T; Hanano M; Sugiyama Y
Effect of perfusate pH on the influx of 5-5'-dimethyl-oxazolidine-2,4-dione and dissociation of epidermal growth factor from the cell-surface receptor: the existence of the proton diffusion barrier in the Disse space.
Journal of hepatology 1994;20(2):190-200.
1994: Sathirakul K; Suzuki H; Yamada T; Hanano M; Sugiyama Y
Multiple transport systems for organic anions across the bile canalicular membrane.
The Journal of pharmacology and experimental therapeutics 1994;268(1):65-73.
1994: Ito K; Sawada Y; Sugiyama Y; Suzuki H; Hanano M; Iga T
Linear relationship between GABAA receptor occupancy of muscimol and glucose metabolic response in the conscious mouse brain. Clinical implication based on comparison with benzodiazepine receptor agonist.
Drug metabolism and disposition: the biological fate of chemicals 1994;22(1):50-4.
1993: Sathirakul K; Suzuki H; Yasuda K; Hanano M; Tagaya O; Horie T; Sugiyama Y
Kinetic analysis of hepatobiliary transport of organic anions in Eisai hyperbilirubinemic mutant rats.
The Journal of pharmacology and experimental therapeutics 1993;265(3):1301-12.
1993: Liu K X; Kato Y; Yamazaki M; Higuchi O; Nakamura T; Sugiyama Y
Decrease in the hepatic clearance of hepatocyte growth factor in carbon tetrachloride-intoxicated rats.
Hepatology (Baltimore, Md.) 1993;17(4):651-60.
1993: Yamazaki M; Suzuki H; Hanano M; Sugiyama Y
Different relationships between cellular ATP and hepatic uptake among taurocholate, cholate, and organic anions.
The American journal of physiology 1993;264(4 Pt 1):G693-701.
1993: Sathirakul K; Suzuki H; Yasuda K; Hanano M; Sugiyama Y
Construction of a physiologically based pharmacokinetic model to describe the hepatobiliary excretion process of ligands: quantitative estimation of intracellular diffusion.
Biological & pharmaceutical bulletin 1993;16(3):273-9.
1993: Yamazaki M; Suzuki H; Hanano M; Tokui T; Komai T; Sugiyama Y
Na(+)-independent multispecific anion transporter mediates active transport of pravastatin into rat liver.
The American journal of physiology 1993;264(1 Pt 1):G36-44.
1992: Wang H K; Miyachi S; Yamazaki M; Sawada Y; Chung Y B; Iga T; Hanano M; Sugiyama Y
Nonlinear pharmacokinetics of hepatobiliary transport of rose bengal in rats after i.v. bolus administration with varying doses.
Biopharmaceutics & drug disposition 1992;13(9):647-62.
1992: Harashima H; Mamiya M; Yamazaki M; Sawada Y; Iga T; Hanano M; Sugiyama Y
Kinetic modeling of ouabain tissue distribution based on slow and saturable binding to Na,K-ATPase.
Pharmaceutical research 1992;9(12):1607-11.
1992: Kim D C; Hanano M; Kanai Y; Ohnuma N; Sugiyama Y
Localization of binding sites for epidermal growth factor (EGF) in rat kidney: evidence for the existence of low affinity EGF binding sites on the brush border membrane.
Pharmaceutical research 1992;9(11):1394-401.
1992: Liu K X; Kato Y; Narukawa M; Kim D C; Hanano M; Higuchi O; Nakamura T; Sugiyama Y
Importance of the liver in plasma clearance of hepatocyte growth factors in rats.
The American journal of physiology 1992;263(5 Pt 1):G642-9.
1992: Kato Y; Sato H; Ichikawa M; Suzuki H; Sawada Y; Hanano M; Fuwa T; Sugiyama Y
Existence of two pathways for the endocytosis of epidermal growth factor by rat liver: phenylarsine oxide-sensitive and -insensitive pathways.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(18):8507-11.
1992: Ichikawa M; Tsao S C; Lin T H; Miyauchi S; Sawada Y; Iga T; Hanano M; Sugiyama Y
'Albumin-mediated transport phenomenon' observed for ligands with high membrane permeability. Effect of the unstirred water layer in the Disse's space of rat liver.
Journal of hepatology 1992;16(1-2):38-49.
1992: Watanabe T; Miyauchi S; Sawada Y; Iga T; Hanano M; Inaba M; Sugiyama Y
Kinetic analysis of hepatobiliary transport of vincristine in perfused rat liver. Possible roles of P-glycoprotein in biliary excretion of vincristine.
Journal of hepatology 1992;16(1-2):77-88.
1992: Harashima H; Mamiya M; Yamazaki M; Sugiyama Y; Sawada Y; Iga T; Hanano M
Significance of binding to Na,K-ATPase in the tissue distribution of ouabain in guinea pigs.
Pharmaceutical research 1992;9(4):474-9.
1992: Matsushita H; Suzuki H; Sugiyama Y; Sawada Y; Iga T; Kawaguchi Y; Hanano M
Effect of benzylpenicillin on the disposition of cefodizime in rats: no net effect on total clearance due to decreased hepatobiliary clearance and increased renal clearance.
The Journal of pharmacology and experimental therapeutics 1992;260(2):499-504.
1992: Kim D C; Sugiyama Y; Sawada Y; Hanano M
Renal tubular handling of p-aminohippurate and epidermal growth factor (EGF) in filtering and nonfiltering perfused rat kidneys.
Pharmaceutical research 1992;9(2):271-5.
1992: Yamazaki M; Sugiyama Y; Suzuki H; Iga T; Hanano M
Utilization of ATP-depleted cells in the analysis of taurocholate uptake by isolated rat hepatocytes.
Journal of hepatology 1992;14(1):54-63.
1992: Yamazaki M; Suzuki H; Sugiyama Y; Iga T; Hanano M
Uptake of organic anions by isolated rat hepatocytes. A classification in terms of ATP-dependency.
Journal of hepatology 1992;14(1):41-7.
1992: Kim D C; Sugiyama Y; Kanai Y; Ohnuma N; Hanano M
Localization of epidermal growth factor (EGF) binding sites on antiluminal plasma membrane of rat kidney: autoradiographic study using nonfiltering perfused rat kidney.
Pharmaceutical research 1992;9(1):40-4.
1991: Kim D C; Hanano M; Sawada Y; Iga T; Sugiyama Y
Kinetic analysis of clearance of epidermal growth factor in isolated perfused rat kidney.
The American journal of physiology 1991;261(6 Pt 2):F988-97.
1991: Matsushita H; Suzuki H; Sugiyama Y; Sawada Y; Iga T; Kawaguchi Y; Hanano M
Facilitated transport of cefodizime into the rat central nervous system.
The Journal of pharmacology and experimental therapeutics 1991;259(2):620-5.
1991: Yanai S; Sugiyama Y; Iga T; Fuwa T; Hanano M
Comparison of the methods for determining cell-surface and intracellular receptors for epidermal growth factor in the rat liver.
Pharmaceutical research 1991;8(5):557-62.
1991: Yanai S; Sugiyama Y; Kim D C; Iga T; Fuwa T; Hanano M
Kinetic analysis of receptor-mediated endocytosis of epidermal growth factor by isolated rat hepatocytes.
The American journal of physiology 1991;260(3 Pt 1):C457-67.
1990: Matsushita H; Suzuki H; Sugiyama Y; Sawada Y; Iga T; Hanano M; Kawaguchi Y
Prediction of the pharmacokinetics of cefodizime and cefotetan in humans from pharmacokinetic parameters in animals.
Journal of pharmacobio-dynamics 1990;13(10):602-11.
1990: Chung Y B; Miyauchi S; Sugiyama Y; Harashima H; Iga T; Hanano M
Effect of various organic anions on the plasma disappearance of 1-anilino-8-naphthalene sulfonate.
Journal of hepatology 1990;11(2):240-51.
1990: Chung Y B; Miyauchi S; Sugiyama Y; Harashima H; Iga T; Hanano M
Kinetic analysis of the dose-dependent hepatic handling of 1-anilino-8-naphthalene sulfonate in rats.
Journal of pharmacokinetics and biopharmaceutics 1990;18(4):313-33.
1990: Sato H; Sugiyama Y; Sawada Y; Iga T; Fuwa T; Hanano M
Internalization of EGF in perfused rat liver is independent of the degree of receptor occupancy.
The American journal of physiology 1990;258(5 Pt 1):G682-9.
1990: Sugiyama Y; Takikawa H
[Transport proteins for drugs and bile acids in the liver cytosol and plasma membrane--its multiplicity and functions]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1990;35(6):941-56.
1990: Yanai S; Sugiyama Y; Iga T; Fuwa T; Hanano M
Kinetic analysis of the downregulation of epidermal growth factor receptors in rats in vivo.
The American journal of physiology 1990;258(4 Pt 1):C593-8.
1990: Ito K; Sawada Y; Ishizuka H; Sugiyama Y; Suzuki H; Iga T; Hanano M
Measurement of cerebral glucose utilization from brain uptake of [14C]2-deoxyglucose and [3H]3-O-methylglucose in the mouse.
Journal of pharmacological methods 1990;23(2):129-40.
1990: Sugiyama Y
[Kinetic analysis of hepatic transport of bioactive polypeptides based on receptor-mediated endocytosis: EGF as a model polypeptide]
Seikagaku. The Journal of Japanese Biochemical Society 1990;62(3):184-92.
1989: Ishizuka H; Sawada Y; Ito K; Sugiyama Y; Suzuki H; Iga T; Hanano M
Nonlinear relationship between benzodiazepine receptor occupancy and glucose metabolic response in the conscious mouse brain in vivo.
The Journal of pharmacology and experimental therapeutics 1989;251(1):362-7.
1989: Suzuki H; Sawada Y; Sugiyama Y; Iga T; Hanano M; Spector R
Transport of imipenem, a novel carbapenem antibiotic, in the rat central nervous system.
The Journal of pharmacology and experimental therapeutics 1989;250(3):979-84.
1989: Sato H; Sugiyama Y; Kim D C; Yanai S; Kurita M; Fuwa T; Iga T; Hanano M
Decrease in the number of receptors for epidermal growth factor in the liver of D-galactosamine-intoxicated rats.
Biochemical pharmacology 1989;38(16):2663-71.
1989: Nohjoh T; Suzuki H; Sawada Y; Sugiyama Y; Iga T; Hanano M
Transport of cefodizime, a novel third generation cephalosporin antibiotic, in isolated rat choroid plexus.
The Journal of pharmacology and experimental therapeutics 1989;250(1):324-8.
1989: Iwatsubo T; Yamazaki M; Sugiyama Y; Suzuki H; Yanai S; Kim D C; Satoh H; Miyamoto Y; Iga T; Hanano M
Epidermal growth factor as a regulatory hormone maintaining a low pH microclimate in the rat small intestine.
Journal of pharmaceutical sciences 1989;78(6):457-9.
1989: Okudaira N; Sawada Y; Sugiyama Y; Iga T; Hanano M
Effect of procainamide on renal tubular transport of cimetidine in the isolated perfused rat kidney.
Biochimica et biophysica acta 1989;981(1):1-7.
1989: Suzuki H; Sawada Y; Sugiyama Y; Iga T; Hanano M
Facilitated transport of benzylpenicillin through the blood-brain barrier in rats.
Journal of pharmacobio-dynamics 1989;12(3):182-5.
1989: Wierzba K; Sugiyama Y; Okudaira K; Iga T; Hanano M
Uptake of colchicine, a microtubular system disrupting agent, by isolated rat hepatocytes.
Pharmaceutical research 1989;6(3):235-8.
1989: Sugiyama Y; Hanano M
Receptor-mediated transport of peptide hormones and its importance in the overall hormone disposition in the body.
Pharmaceutical research 1989;6(3):192-202.
1989: Yachi K; Sugiyama Y; Sawada Y; Iga T; Ikeda Y; Toda G; Hanano M
Characterization of Rose Bengal binding to sinusoidal and bile canalicular plasma membrane from rat liver.
Biochimica et biophysica acta 1989;978(1):1-7.
1989: Kim D C; Sugiyama Y; Fuwa T; Sakamoto S; Iga T; Hanano M
Kinetic analysis of the elimination process of human epidermal growth factor (hEGF) in rats.
Biochemical pharmacology 1989;38(2):241-9.
1989: Okudaira K; Sawada Y; Sugiyama Y; Iga T; Hanano M
Effect of quinidine on the hepatic uptake of digoxin in guinea pigs.
Journal of pharmacobio-dynamics 1989;12(1):24-30.
1988: Sato H; Sugiyama Y; Sawada Y; Iga T; Sakamoto S; Fuwa T; Hanano M
Dynamic determination of kinetic parameters for the interaction between polypeptide hormones and cell-surface receptors in the perfused rat liver by the multiple-indicator dilution method.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(21):8355-9.
1988: Wierzba K; Sugiyama Y; Iga T; Hanano M
Kinetic study on the mechanism of tissue distribution of vinblastine.
Journal of pharmacobio-dynamics 1988;11(10):651-61.
1988: Kawasaki S; Sugiyama Y; Iga T; Hanano M; Beppu T; Sugiura M; Sanjo K; Idezuki Y
Hepatic clearances of antipyrine, indocyanine green, and galactose in normal subjects and in patients with chronic liver diseases.
Clinical pharmacology and therapeutics 1988;44(2):217-24.
1988: Lin T H; Sugiyama Y; Sawada Y; Iga T; Hanano M
Dialyzable serum cofactor(s) required for the protein-mediated transport of DL-propranolol into rat brain.
Biochemical pharmacology 1988;37(15):2957-61.
1988: Okudaira K; Sawada Y; Sugiyama Y; Iga T; Hanano M
Effects of basic drugs on the hepatic transport of cardiac glycosides in rats.
Biochemical pharmacology 1988;37(15):2949-55.
1988: Miyauchi S; Sugiyama Y; Iga T; Hanano M
Membrane-limited hepatic transport of the conjugative metabolites of 4-methylumbelliferone in rats.
Journal of pharmaceutical sciences 1988;77(8):688-92.
1988: Harashima H; Sugiyama Y; Sawada Y; Shigenobu K; Kasuya Y; Iga T; Hanano M
Kinetic analysis of the positive inotropic action (PIA) of ouabain in isolated perfused rabbit heart. Slow onset of PIA and slow binding to Na+, K+-adenosine triphosphatase.
Journal of pharmacobio-dynamics 1988;11(8):533-40.
1988: Harashima H; Sugiyama Y; Iga T; Hanano M
Nonlinear tissue distribution of ouabain in rabbits.
Drug metabolism and disposition: the biological fate of chemicals 1988;16(4):645-9.
1988: Iwatsubo T; Sugiyama Y; Miyamoto Y; Leibach F H; Suzuki H; Iga T; Hanano M
Effects of phenothiazine derivatives on the microclimate-pH in the rat jejunum.
Journal of pharmaceutical sciences 1988;77(7):586-90.
1988: Sato H; Sugiyama Y; Sawada Y; Iga T; Hanano M
In vivo evidence for the specific binding of human beta-endorphin to the lung and liver of the rat.
Biochemical pharmacology 1988;37(11):2273-8.
1988: Tsao S C; Sugiyama Y; Shinmura K; Sawada Y; Nagase S; Iga T; Hanano M
Protein-mediated hepatic uptake of rose bengal in analbuminemic mutant rats (NAR). Albumin is not indispensable to the protein-mediated transport of rose bengal.
Drug metabolism and disposition: the biological fate of chemicals 1988;16(3):482-9.
1988: Tsao S C; Sugiyama Y; Sawada Y; Iga T; Hanano M
Kinetic analysis of albumin-mediated uptake of warfarin by perfused rat liver.
Journal of pharmacokinetics and biopharmaceutics 1988;16(2):165-81.
1988: Kurihara A; Suzuki H; Sawada Y; Sugiyama Y; Iga T; Hanano M
Transport of digoxin into brain microvessels and choroid plexuses isolated from guinea pig.
Journal of pharmaceutical sciences 1988;77(4):347-52.
1988: Yachi K; Sugiyama Y; Sato H; Kim D C; Fuwa T; Iga T; Hanano M
Comparison of specific binding of human epidermal growth factor (EGF) to sinusoidal and bile canalicular membranes isolated from rat liver.
Journal of biochemistry 1988;103(3):448-51.
1988: Kim D C; Sugiyama Y; Satoh H; Fuwa T; Iga T; Hanano M
Kinetic analysis of in vivo receptor-dependent binding of human epidermal growth factor by rat tissues.
Journal of pharmaceutical sciences 1988;77(3):200-7.
1988: Suzuki H; Sawada Y; Sugiyama Y; Iga T; Hanano M
Efflux of cimetidine from the rat cerebrospinal fluid.
Drug metabolism and disposition: the biological fate of chemicals 1988;16(2):328-30.
1988: Lin T H; Sugiyama Y; Sawada Y; Kawasaki S; Iga T; Hanano M
Effect of serum from renal failure and cirrhotic patients on the blood-brain barrier permeability to DL-propranolol in rats.
Drug metabolism and disposition: the biological fate of chemicals 1988;16(2):290-5.
1987: Suzuki H; Sawada Y; Sugiyama Y; Iga T; Hanano M
Anion exchanger mediates benzylpenicillin transport in rat choroid plexus.
The Journal of pharmacology and experimental therapeutics 1987;243(3):1147-52.
1987: Wierzba K; Sugiyama Y; Okudaira K; Iga T; Hanano M
Tubulin as a major determinant of tissue distribution of vincristine.
Journal of pharmaceutical sciences 1987;76(12):872-5.
1987: Lin T H; Sawada Y; Sugiyama Y; Iga T; Hanano M
Inhibition of blood-brain barrier permeability to DL-propranolol by serum from acute renal failure rats.
Biochemical pharmacology 1987;36(20):3425-31.
1987: Kurihara A; Suzuki H; Sawada Y; Sugiyama Y; Iga T; Hanano M
Uptake of propranolol by microvessels isolated from bovine brain.
Journal of pharmaceutical sciences 1987;76(10):759-64.
1987: Miyauchi S; Sugiyama Y; Sato H; Sawada Y; Iga T; Hanano M
Effect of a diffusional barrier to a metabolite across hepatocytes on its kinetics in "enzyme-distributed" models: a computer-aided simulation study.
Journal of pharmacokinetics and biopharmaceutics 1987;15(4):399-421.
1987: Sato H; Sugiyama Y; Sawada Y; Iga T; Hanano M
Physiologically based pharmacokinetics of radioiodinated human beta-endorphin in rats. An application of the capillary membrane-limited model.
Drug metabolism and disposition: the biological fate of chemicals 1987;15(4):540-50.
1981: Igari Y; Sugiyama Y; Awazu S; Hanano M
Interspecies difference in drug protein binding-temperature and protein concentration dependency: effect on calculation of effective protein fraction.
Journal of pharmaceutical sciences 1981;70(9):1049-53.

Sign-in to see more

Sign-in free and Explore the Exciting World of BiomedExperts:

NetworkView

Yuichi Sugiyama

Research Profile (preview)

Living Beings

Anatomy

Physiology

Chemicals & Drugs

Concepts & Ideas

Network (preview)

Publications

Sign in free and see...

Visualized networks:

GeoTargeted Searches:

Research Profiles:

Geonetwork of Yuichi Sugiyama (preview)

All Publications