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Manickam Sugumaran

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TOP 3
Manickam Sugumaran; Adal Abebe; Owen Oboite; Dong Zheng
On the mechanism of formation of arterenone in insect cuticular hydrolyzates.
Manickam Sugumaran; William E Robinson
Structure, biosynthesis and possible function of tunichromes and related compounds.
Adal Abebe; Dong Zheng; Jason Evans; Manickam Sugumaran
Reexamination of the mechanisms of oxidative transformation of the insect cuticular sclerotizing precursor, 1,2-dehydro-N-acetyldopamine.

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All Publications

2013: Manickam Sugumaran; Adal Abebe; Owen Oboite; Dong Zheng
On the mechanism of formation of arterenone in insect cuticular hydrolyzates.
Insect biochemistry and molecular biology 2013;43(2):209-18.
2012: Manickam Sugumaran; William E Robinson
Structure, biosynthesis and possible function of tunichromes and related compounds.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2012;163(1):1-25.
2010: Adal Abebe; Dong Zheng; Jason Evans; Manickam Sugumaran
Reexamination of the mechanisms of oxidative transformation of the insect cuticular sclerotizing precursor, 1,2-dehydro-N-acetyldopamine.
Insect biochemistry and molecular biology 2010;40(9):650-9.
2010: Manickam Sugumaran; William E Robinson
Bioactive dehydrotyrosyl and dehydrodopyl compounds of marine origin.
Marine drugs 2010;8(12):2906-35.
2008: Mingmei Cai; Manickam Sugumaran; William E Robinson
The crosslinking and antimicrobial properties of tunichrome.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2008;151(1):110-7.
2007: Samantha J Devoid; Ron J Etter; Manickam Sugumaran; Gordon T Wallace; William E Robinson
Histidine-rich glycoprotein from the hemolymph of the marine mussel Mytilus edulis L. binds Class A, Class B, and borderline metals.
Environmental toxicology and chemistry / SETAC 2007;26(5):872-7.
2007: Adal T Abebe; Samantha J Devoid; Manickam Sugumaran; Ron J Etter; William E Robinson
Identification and quantification of histidine-rich glycoprotein (HRG) in the blood plasma of six marine bivalves.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2007;147(1):74-81.
2002: Manickam Sugumaran
Comparative biochemistry of eumelanogenesis and the protective roles of phenoloxidase and melanin in insects.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2002;15(1):2-9.
2001: Michael R Chase; Manickam Sugumaran
Genomic and cDNA sequence of prophenoloxidases from Drosophila melanogaster.
Advances in experimental medicine and biology 2001;484():349-62.
2001: Manickam Sugumaran
Control mechanisms of the prophenoloxidase cascade.
Advances in experimental medicine and biology 2001;484():289-98.
2000: Michael R Chase; K Raina; J Bruno; Manickam Sugumaran
Purification, characterization and molecular cloning of prophenoloxidases from Sarcophaga bullata.
Insect biochemistry and molecular biology 2000;30(10):953-67.
2000: Manickam Sugumaran; K Nellaiappan; K Valivittan
A new mechanism for the control of phenoloxidase activity: inhibition and complex formation with quinone isomerase.
Archives of biochemistry and biophysics 2000;379(2):252-60.
2000: Manickam Sugumaran
Oxidation chemistry of 1,2-dehydro-N-acetyldopamines: direct evidence for the formation of 1,2-dehydro-N-acetyldopamine quinone.
Archives of biochemistry and biophysics 2000;378(2):404-10.
2000: Manickam Sugumaran; K Nellaiappan; C Amaratunga; S Cardinale; T Scott
Insect melanogenesis. III. Metabolon formation in the melanogenic pathway-regulation of phenoloxidase activityy by endogenous dopachrome isomerase (decarboxylating) from Manduca sexta.
Archives of biochemistry and biophysics 2000;378(2):393-403.
2000: Manickam Sugumaran; K Nellaiappan
Characterization of a new phenoloxidase inhibitor from the cuticle of Manduca sexta.
Biochemical and biophysical research communications 2000;268(2):379-83.
1999: Manickam Sugumaran; P Duggaraju; E Jayachandran; K L Kirk
Formation of a new quinone methide intermediate during the oxidative transformation of 3,4-dihydroxyphenylacetic acids: implication for eumelanin biosynthesis.
Archives of biochemistry and biophysics 1999;371(1):98-106.
1999: Manickam Sugumaran; R Duggaraju; F Generozova; S Ito
Insect melanogenesis. II. Inability of Manduca phenoloxidase to act on 5,6-dihydroxyindole-2-carboxylic acid.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 1999;12(2):118-25.
1998: Manickam Sugumaran; Judy L Bolton
Laccase--and not tyrosinase--is the enzyme responsible for quinone methide production from 2,6-dimethoxy-4-allyl phenol.
Archives of biochemistry and biophysics 1998;353(2):207-12.
1998: Manickam Sugumaran; E Nelson
Model sclerotization studies. 4. Generation of N-acetylmethionyl catechol adducts during tyrosinase-catalyzed oxidation of catechols in the presence of N-acetylmethionine.
Archives of insect biochemistry and physiology 1998;38(1):44-52.
1996: Manickam Sugumaran; S Tan; H L Sun
Tyrosinase-catalyzed oxidation of 3,4-dihydroxyphenylglycine.
Archives of biochemistry and biophysics 1996;329(2):175-80.
1996: G Beck; S Cardinale; L Wang; M Reiner; Manickam Sugumaran
Characterization of a defense complex consisting of interleukin 1 and phenol oxidase from the hemolymph of the tobacco hornworm, Manduca sexta.
The Journal of biological chemistry 1996;271(19):11035-8.
1996: K Nellaiappan; Manickam Sugumaran
On the presence of prophenoloxidase in the hemolymph of the horseshoe crab, Limulus.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 1996;113(1):163-8.
1995: Manickam Sugumaran
Oxidation of 3,4-dihydroxybenzylamine affords 3,4-dihydroxybenzaldehyde via the quinone methide intermediate.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 1995;8(5):250-4.
1995: G Nicklas; Manickam Sugumaran
Detection of dopachrome isomerase on gels and membranes.
Analytical biochemistry 1995;230(2):248-53.
1995: Manickam Sugumaran; J Bolton
Direct evidence for quinone-quinone methide tautomerism during tyrosinase catalyzed oxidation of 4-allylcatechol.
Biochemical and biophysical research communications 1995;213(2):469-74.
1995: M Hall; T Scott; Manickam Sugumaran; K Söderhäll; John H Law
Proenzyme of Manduca sexta phenol oxidase: purification, activation, substrate specificity of the active enzyme, and molecular cloning.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(17):7764-8.
1995: Manickam Sugumaran; K Nellaiappan; T Scott; C Amaratunga
Complex formation between mushroom tyrosinase and Manduca dopachrome isomerase.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 1995;8(4):180-6.
1995: Manickam Sugumaran
A caution about the azide inhibition of enzymes associated with electrophilic metabolites.
Biochemical and biophysical research communications 1995;212(3):834-9.
1995: Manickam Sugumaran; D Ricketts
Model sclerotization studies. 3. Cuticular enzyme catalyzed oxidation of peptidyl model tyrosine and dopa derivatives.
Archives of insect biochemistry and physiology 1995;28(1):17-32.
1994: D Ricketts; Manickam Sugumaran
1,2-dehydro-N-beta-alanyldopamine as a new intermediate in insect cuticular sclerotization.
The Journal of biological chemistry 1994;269(35):22217-21.
1994: K Nellaiappan; G Nicklas; Manickam Sugumaran
Detection of dopachrome isomerase activity on gels.
Analytical biochemistry 1994;220(1):122-8.
1994: K Nellaiappan; G Nicklas; Manickam Sugumaran
The ontogeny of dopachrome isomerase isozyme patterns in the tobacco hornworm Manduca sexta.
Biochemical and biophysical research communications 1994;200(2):1072-8.
1992: Manickam Sugumaran; V Semensi; B Kalyanaraman; J M Bruce; Edward J Land
Evidence for the formation of a quinone methide during the oxidation of the insect cuticular sclerotizing precursor 1,2-dehydro-N-acetyldopamine.
The Journal of biological chemistry 1992;267(15):10355-61.
1992: Manickam Sugumaran; H Dali; V Semensi
Mechanistic studies on tyrosinase-catalysed oxidative decarboxylation of 3,4-dihydroxymandelic acid.
The Biochemical journal 1992;281 ( Pt 2)():353-7.
1992: Manickam Sugumaran; L Giglio; H Kundzicz; S Saul; V Semensi
Studies on the enzymes involved in puparial cuticle sclerotization in Drosophila melanogaster.
Archives of insect biochemistry and physiology 1992;19(4):271-83.
1991: Manickam Sugumaran
Molecular mechanisms for mammalian melanogenesis. Comparison with insect cuticular sclerotization.
FEBS letters 1991;295(1-3):233-9.
1991: Manickam Sugumaran; H Dali; V Semensi
The mechanism of tyrosinase-catalysed oxidative decarboxylation of alpha-(3,4-dihydroxyphenyl)-lactic acid.
The Biochemical journal 1991;277 ( Pt 3)():849-53.
1991: Manickam Sugumaran; K Nellaiappan
Lysolecithin--a potent activator of prophenoloxidase from the hemolymph of the lobster, Homarus americanas.
Biochemical and biophysical research communications 1991;176(3):1371-6.
1991: Manickam Sugumaran; V Semensi
Quinone methide as a new intermediate in eumelanin biosynthesis.
The Journal of biological chemistry 1991;266(10):6073-8.
1991: S J Saul; Manickam Sugumaran
Quinone methide as a reactive intermediate formed during the biosynthesis of papiliochrome II, a yellow wing pigment of papilionid butterflies.
FEBS letters 1991;279(1):145-8.
1991: S J Saul; H Dali; Manickam Sugumaran
Quinone and quinone methide as transient intermediates involved in the side chain hydroxylation of N-acyldopamine derivatives by soluble enzymes from Manduca sexta cuticle.
Archives of insect biochemistry and physiology 1991;16(2):123-38.
1991: Manickam Sugumaran; V Semensi; H Dali; K Nellaiappan
Oxidation of 3,4-dihydroxybenzyl alcohol: a sclerotizing precursor for cockroach ootheca.
Archives of insect biochemistry and physiology 1991;16(1):31-44.
1990: S J Saul; Manickam Sugumaran
4-alkyl-o-quinone/2-hydroxy-p-quinone methide isomerase from the larval hemolymph of Sarcophaga bullata. I. Purification and characterization of enzyme-catalyzed reaction.
The Journal of biological chemistry 1990;265(28):16992-9.
1990: Manickam Sugumaran; K Schinkmann; H Dali
Mechanism of activation of 1,2-dehydro-N-acetyldopamine for cuticular sclerotization.
Archives of insect biochemistry and physiology 1990;14(2):93-109.
1990: Manickam Sugumaran; S J Saul; H Dali
On the mechanism of side chain oxidation of N-beta-alanyldopamine by cuticular enzymes from Sarcophaga bullata.
Archives of insect biochemistry and physiology 1990;15(4):255-69.
1990: S J Saul; Manickam Sugumaran
Biosynthesis of dehydro-N-acetyldopamine by a soluble enzyme preparation from the larval cuticle of Sarcophaga bullata involves intermediary formation of N-acetyldopamine quinone and N-acetyldopamine quinone methide.
Archives of insect biochemistry and physiology 1990;15(4):237-54.
1990: Manickam Sugumaran; K Nellaiappan
On the latency and nature of phenoloxidase present in the left colleterial gland of the cockroach Periplaneta americana.
Archives of insect biochemistry and physiology 1990;15(3):165-81.
1989: Manickam Sugumaran; V Semensi; H Dali; S Saul
Nonenzymatic transformations of enzymatically generated N-acetyldopamine quinone and isomeric dihydrocaffeiyl methyl amide quinone.
FEBS letters 1989;255(2):345-9.
1989: S J Saul; Manickam Sugumaran
N-acetyldopamine quinone methide/1,2-dehydro-N-acetyl dopamine tautomerase. A new enzyme involved in sclerotization of insect cuticle.
FEBS letters 1989;255(2):340-4.
1989: Manickam Sugumaran; S Saul; V Semensi
Trapping of transiently formed quinone methide during enzymatic conversion of N-acetyldopamine to N-acetylnorepinephrine.
FEBS letters 1989;252(1-2):135-8.
1989: S J Saul; Manickam Sugumaran
Characterization of a new enzyme system that desaturates the side chain of N-acetyldopamine.
FEBS letters 1989;251(1-2):69-73.
1989: S J Saul; Manickam Sugumaran
o-quinone/quinone methide isomerase: a novel enzyme preventing the destruction of self-matter by phenoloxidase-generated quinones during immune response in insects.
FEBS letters 1989;249(2):155-8.
1988: S Saul; Manickam Sugumaran
A novel quinone: quinone methide isomerase generates quinone methides in insect cuticle.
FEBS letters 1988;237(1-2):155-8.
1988: N Ramesh; Manickam Sugumaran; J E Mole
Purification and characterization of two trypsin inhibitors from the hemolymph of Manduca sexta larvae.
The Journal of biological chemistry 1988;263(23):11523-7.
1987: Manickam Sugumaran; H Dali; V Semensi; B Hennigan
Tyrosinase-catalyzed unusual oxidative dimerization of 1,2-dehydro-N-acetyldopamine.
The Journal of biological chemistry 1987;262(22):10546-9.
1987: Manickam Sugumaran; V Semensi
Sclerotization of mosquito cuticle.
Experientia 1987;43(2):172-4.
1987: S J Saul; L Bin; Manickam Sugumaran
The majority of prophenoloxidase in the hemolymph of Manduca sexta is present in the plasma and not in the hemocytes.
Developmental and comparative immunology 1987;11(3):479-85.
1986: S J Saul; Manickam Sugumaran
Protease inhibitor controls prophenoloxidase activation in Manduca sexta.
FEBS letters 1986;208(1):113-6.
1985: Manickam Sugumaran; S J Saul; N Ramesh
Endogenous protease inhibitors prevent undesired activation of prophenolase in insect hemolymph.
Biochemical and biophysical research communications 1985;132(3):1124-9.
1982: Manickam Sugumaran; H Lipke
Crosslink precursors for the dipteran puparium.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(8):2480-4.