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Yousin Suh

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Si-Young Cho; Sang Jun Lee; Dae Bang Seo; Miook Cho; Yousin Suh
Identification of a small molecule activator of SIRT1 gene expression.
Jeehae Han; Basil P Hubbard; Han-Woong Lee; Jaehoon Lee; Cristina Montagna; David A Sinclair; Yousin Suh
Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene.
Jan Vijg; Yousin Suh
Genome instability and aging.

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All Publications

2013: Si-Young Cho; Sang Jun Lee; Dae Bang Seo; Miook Cho; Yousin Suh
Identification of a small molecule activator of SIRT1 gene expression.
Aging 2013;5(3):174-82.
2013: Jeehae Han; Basil P Hubbard; Han-Woong Lee; Jaehoon Lee; Cristina Montagna; David A Sinclair; Yousin Suh
Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene.
Cell cycle (Georgetown, Tex.) 2013;12(2):263-70.
2013: Jan Vijg; Yousin Suh
Genome instability and aging.
Annual review of physiology 2013;75():645-68.
2012: Alexander Maslov; N Strogonova; Yousin Suh; C Tazearslan; A Bendebury; S Gravina; M Gundry; M Lee; Jan Vijg
5-aza-2'-deoxycytidine-induced genome rearrangements are mediated by DNMT1.
Oncogene 2012;31(50):5172-9.
2012: Baohua Liu; Xinguang Liu; Yousin Suh; Karl Tryggvason; Zimei Wang; Xi Yang; Bojian Zheng; Huiling Zheng; Shrestha Ghosh; Guoxiang Jin; Matt Kaeberlein; Brian K Kennedy; Zhongjun Zhou
Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria.
Cell metabolism 2012;16(6):738-50.
2012: Ling Zhao; Gu-Yan Zheng; Zhiming Zhu; Ke Xu; Fan Yang; Yi Zeng; Yan Zhang; Huiqing Cao; Xiaomin Chen; Hanbin Cui; Hongbo He; Brian K Kennedy; Jianxin Li; Xianming Mo; Yousin Suh; Xiao-Li Tian
Common genetic variants of the β2-adrenergic receptor affect its translational efficiency and are associated with human longevity.
Aging cell 2012;11(6):1094-101.
2012: Hwa Jin Jung; Yousin Suh
MicroRNA in Aging: From Discovery to Biology.
Current genomics 2012;13(7):548-57.
2012: MiJung Kim; MinHwan Kim; ChanJeoung Park; Yu Suk Choi; ChanWha Kim; Yousin Suh
Age-related alterations in mesenchymal stem cells related to shift in differentiation from osteogenic to adipogenic potential: implication to age-associated bone diseases and defects.
Mechanisms of ageing and development 2012;133(5):215-25.
2012: Yousin Suh; Brian K Kennedy
Dialing down SUN1 for laminopathies.
Cell 2012;149(3):509-10.
2012: Cagdas Tazearslan; Miook Cho; Yousin Suh
Discovery of functional gene variants associated with human longevity: opportunities and challenges.
The journals of gerontology. Series A, Biological sciences and medical sciences 2012;67(4):376-83.
2012: Saurabh Gombar; Jan H J Hoeijmakers; Hwa Jin Jung; Joris Pothof; Gil Atzmon; Nir Barzilai; Brent Calder; Judith Campisi; Feng Dong; Xiao-Li Tian; Jan Vijg; Yousin Suh
Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing.
BMC genomics 2012;13():353.
2011: Joe R Delaney; Brian K Kennedy; Ben Dulken; Yousin Suh; Scott Tsuchiyama; Bin Liu; Daniel Carr; Brett Robison; Annie Chou; Kristan K Steffen; Kim M Pham; Simon Johnson; Diana N Pak; Christopher J Murakami; George L Sutphin; Jin R Kim; Eunice Choi; Richard M Moller; Amrita Solanky; Monika Jelic; Zhao J Peng; Marissa Fletcher; Daniel Lockshon; Qi Peng; Elroy H An; Michael Sage; Mitsuhiro Tsuchiya; Xinguang Liu; Chris Raabe; Zhongjun Zhou; Jennifer Schleit; Sylvia Sim; Matt Kaeberlein
Sir2 deletion prevents lifespan extension in 32 long-lived mutants.
Aging cell 2011;10(6):1089-91.
2011: Matt Kaeberlein; Brian K Kennedy; Xinguang Liu; Yousin Suh; Zhongjun Zhou
Trinations aging symposium.
Mechanisms of ageing and development 2011;132(6-7):348-52.
2011: Cagdas Tazearslan; Jing Huang; Nir Barzilai; Yousin Suh
Impaired IGF1R signaling in cells expressing longevity-associated human IGF1R alleles.
Aging cell 2011;10(3):551-4.
2011: Hae Ri Choi; Kyung A Cho; hyun tae kang; Jung Bin Lee; Matt Kaeberlein; Yousin Suh; In Kwon Chung; Sang Chul Park
Restoration of senescent human diploid fibroblasts by modulation of the extracellular matrix.
Aging cell 2011;10(1):148-57.
2010: Nir Barzilai; Ilan Gabriely; Gil Atzmon; Devorah Rothenberg; Yousin Suh; Aviv Bergman
Genetic studies reveal the role of the endocrine and metabolic systems in aging.
The Journal of clinical endocrinology and metabolism 2010;95(10):4493-500.
2010: Young Sun Oh; Dae Gyu Kim; Gyuyoup Kim; Eung-Chil Choi; Brian K Kennedy; Yousin Suh; Bum Joon Park; Sunghoon Kim
Downregulation of lamin A by tumor suppressor AIMP3/p18 leads to a progeroid phenotype in mice.
Aging cell 2010;9(5):810-22.
2010: Yousin Suh; Jan Vijg
The long and short of fertility and longevity.
Cell metabolism 2010;12(3):209-10.
2010: Gil Atzmon; Miook Cho; Richard M Cawthon; Temuri Budagov; Micol Katz; Xiaoman Yang; Glenn Siegel; Aviv Bergman; Derek M Huffman; Clyde Schechter; Woodring E Wright; Jerry W Shay; Nir Barzilai; Diddahally R Govindaraju; Yousin Suh
Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians.
Proceedings of the National Academy of Sciences of the United States of America 2010;107 Suppl 1():1710-7.
2008: Jeongkyung Lee; Pradip K Saha; Qi-Heng Yang; Seunghee Lee; Jung Yoon Park; Yousin Suh; Soo-Kyung Lee; Lawrence Chan; Robert G Roeder; Jae W Lee
Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(49):19229-34.
2008: Jan Vijg; Alexander Maslov; Yousin Suh
Aging: a sirtuin shake-up?
Cell 2008;135(5):797-8.
2008: Yousin Suh; Gil Atzmon; Mi-Ook Cho; David Hwang; Bingrong Liu; Daniel J Leahy; Nir Barzilai; Pinchas Cohen
Functionally significant insulin-like growth factor I receptor mutations in centenarians.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(9):3438-42.
2008: Rita A Busuttil; Denise P Muñoz; Ana Maria Garcia; Francis Rodier; Woo Ho Kim; Yousin Suh; Edward Hasty; Judith Campisi; Jan Vijg
Effect of Ku80 deficiency on mutation frequencies and spectra at a LacZ reporter locus in mouse tissues and cells.
PloS one 2008;3(10):e3458.
2008: Björn Schumacher; Ingrid van der Pluijm; Michael J Moorhouse; Theodore Kosteas; Andria Rasile Robinson; Yousin Suh; Timo M Breit; Harry van Steeg; Laura J Niedernhofer; Wilfred van Ijcken; Andrzej Bartke; Stephen R Spindler; Jan H J Hoeijmakers; Gijsbertus T J van der Horst; George A Garinis
Delayed and accelerated aging share common longevity assurance mechanisms.
PLoS genetics 2008;4(8):e1000161.
2008: Jung Yoon Park; Mi-Ook Cho; Shanique Leonard; Brent Calder; I Saira Mian; Woo Ho Kim; Susan Wijnhoven; Harry van Steeg; James Mitchell; Gijsbertus T J van der Horst; Jan Hoeijmakers; Pinchas Cohen; Jan Vijg; Yousin Suh
Homeostatic imbalance between apoptosis and cell renewal in the liver of premature aging Xpd mice.
PloS one 2008;3(6):e2346.
2007: Bongkun Choi; Yousin Suh; Woo Ho Kim; Laurence Christa; Joobae Park; Chang-Dae Bae
Downregulation of regenerating islet-derived 3 alpha (REG3A) in primary human gastric adenocarcinomas.
Experimental & molecular medicine 2007;39(6):796-804.
2007: Ji Ha Choi; Byung Min Ahn; Jihyun Yi; Ji Hyun Lee; Jeong Ho Lee; Suk Woo Nam; Chae Yoon Chon; Kwang-Hyub Han; Sang Hoon Ahn; In-Jin Jang; Joo-Youn Cho; Yousin Suh; Mi-Ook Cho; Jong-Eun Lee; Kyung Hwan Kim; Min Goo Lee
MRP2 haplotypes confer differential susceptibility to toxic liver injury.
Pharmacogenetics and genomics 2007;17(6):403-15.
2007: Marieke van de Ven; Jaan-Olle Andressoo; Valerie B Holcomb; Edward Hasty; Yousin Suh; Harry van Steeg; george garinis; Jan H J Hoeijmakers; James R Mitchell
Extended longevity mechanisms in short-lived progeroid mice: identification of a preservative stress response associated with successful aging.
Mechanisms of ageing and development 2007;128(1):58-63.
2006: Marieke van de Ven; Jaan-Olle Andressoo; Valerie B Holcomb; Marieke von Lindern; Willeke M C Jong; Chris I De Zeeuw; Yousin Suh; Edward Hasty; Jan H J Hoeijmakers; Gijsbertus T J van der Horst; James R Mitchell
Adaptive stress response in segmental progeria resembles long-lived dwarfism and calorie restriction in mice.
PLoS genetics 2006;2(12):e192.
2006: Jan Vijg; Yousin Suh
Ageing: chromatin unbound.
Nature 2006;440(7086):874-5.
2006: Yousin Suh; Jan Vijg
Maintaining genetic integrity in aging: a zero sum game.
Antioxidants & redox signaling 2006;8(3-4):559-71.
2005: Rita A Busuttil; Ana Maria Garcia; Carlos Cabrera; Armando Rodriguez; Yousin Suh; Woo Ho Kim; Ting-Ting Huang; Jan Vijg
Organ-specific increase in mutation accumulation and apoptosis rate in CuZn-superoxide dismutase-deficient mice.
Cancer research 2005;65(24):11271-5.
2005: Yousin Suh; Jan Vijg
SNP discovery in associating genetic variation with human disease phenotypes.
Mutation research 2005;573(1-2):41-53.
2005: Yousin Suh; Charles Cantor
Single nucleotide polymorphisms (SNPs): detection, interpretation, and application.
Mutation research 2005;573(1-2):1-2.
2005: Jan Vijg; Yousin Suh
Genetics of longevity and aging.
Annual review of medicine 2005;56():193-212.
2003: Chang-Dae Bae; Yeon-Sun Sung; Sang-Min Jeon; Yousin Suh; Han-Kwan Yang; Yong Il Kim; Ki-Ho Park; Jongsun Choi; Geunghwan Ahn; Joobae Park
Up-regulation of cytoskeletal-associated protein 2 in primary human gastric adenocarcinomas.
Journal of cancer research and clinical oncology 2003;129(11):621-30.
2003: Ji Hyun Lee; Ji Ha Choi; Wan Namkung; John W Hanrahan; Joon Chang; Si Young Song; Seung Woo Park; Dong Soo Kim; Joo-Heon Yoon; Yousin Suh; In-Jin Jang; Joo Hyun Nam; Sung Joon Kim; Mi-Ook Cho; Jong-Eun Lee; Kyung Hwan Kim; Min Goo Lee
A haplotype-based molecular analysis of CFTR mutations associated with respiratory and pancreatic diseases.
Human molecular genetics 2003;12(18):2321-32.
2003: M Bounpheng; S McGrath; D Macias; Nathalie J van Orsouw; Yousin Suh; D Rines; Jan Vijg
Rapid, inexpensive scanning for all possible BRCA1 and BRCA2 gene sequence variants in a single assay: implications for genetic testing.
Journal of medical genetics 2003;40(4):e33.
2003: Jan Vijg; Yousin Suh
Functional genomics of ageing.
Mechanisms of ageing and development 2003;124(1):3-8.
2002: Yousin Suh
Cell signaling in aging and apoptosis.
Mechanisms of ageing and development 2002;123(8):881-90.
2002: Yousin Suh; Kang-Ae Lee; Woo Ho Kim; Bok Ghee Han; Jan Vijg; Sang Chul Park
Aging alters the apoptotic response to genotoxic stress.
Nature medicine 2002;8(1):3-4.
2001: S B McGrath; M Bounpheng; L Torres; M Calavetta; C B Scott; Yousin Suh; D Rines; Nathalie J van Orsouw; Jan Vijg
High-speed, multicolor fluorescent two-dimensional gene scanning.
Genomics 2001;78(1-2):83-90.
2001: C M Kang; Yousin Suh; Ik-Soon Jang; Sang Chul Park
Thymidine-dependent attenuation of the mitochondrial apoptotic pathway in adenosine-induced apoptosis of HL-60 cells.
Journal of cancer research and clinical oncology 2001;127(9):570-6.