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Robert Suhadolnik

Research Profile

Chemicals & Drugs

Concepts & Ideas

Physiology

Living Beings

HIV-1

Anatomy

Disorders

Fatigue Syndrome, Chronic

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Dessislava I Dimitrova; Nancy L Reichenbach; Xiaowei Yang; Wolfgang Pfleiderer; Ramamurthy Charubala; John P Gaughan; Byungse Suh; Earl E Henderson; Robert J Suhadolnik; Thomas J Rogers
Inhibition of HIV type 1 replication in CD4+ and CD14+ cells purified from HIV type 1-infected individuals by the 2-5A agonist immunomodulator, 2-5A(N6B).
Dessislava I Dimitrova; Xiaowei Yang; Nancy L Reichenbach; Stephanos Karakasidis; Richard E Sutton; Earl E Henderson; Thomas J Rogers; Robert J Suhadolnik
Lentivirus-mediated transduction of PKR into CD34(+) hematopoietic stem cells inhibits HIV-1 replication in differentiated T cell progeny.
Kenny De Meirleir; Robert J Suhadolnik; Bernard Lebleu; Patrick Englebienne
Antiviral pathway activation in chronic fatigue syndrome and acute infection.

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2007: Dessislava I Dimitrova; Nancy L Reichenbach; Xiaowei Yang; Wolfgang Pfleiderer; Ramamurthy Charubala; John P Gaughan; Byungse Suh; Earl E Henderson; Robert J Suhadolnik; Thomas J Rogers
Inhibition of HIV type 1 replication in CD4+ and CD14+ cells purified from HIV type 1-infected individuals by the 2-5A agonist immunomodulator, 2-5A(N6B).
AIDS research and human retroviruses 2007;23(1):123-34.
2005: Dessislava I Dimitrova; Xiaowei Yang; Nancy L Reichenbach; Stephanos Karakasidis; Richard E Sutton; Earl E Henderson; Thomas J Rogers; Robert J Suhadolnik
Lentivirus-mediated transduction of PKR into CD34(+) hematopoietic stem cells inhibits HIV-1 replication in differentiated T cell progeny.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2005;25(6):345-60.
2002: Kenny De Meirleir; Robert J Suhadolnik; Bernard Lebleu; Patrick Englebienne
Antiviral pathway activation in chronic fatigue syndrome and acute infection.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2002;34(10):1420-1; author reply 1421-2.
2002: Joseph W Homan; Amber D Steele; Camille Martinand-Mari; Thomas J Rogers; Earl E Henderson; Ramamurthy Charubala; Wolfgang Pfleiderer; Nancy L Reichenbach; Robert J Suhadolnik
Inhibition of morphine-potentiated HIV-1 replication in peripheral blood mononuclear cells with the nuclease-resistant 2-5A agonist analog, 2-5A(N6B).
Journal of acquired immune deficiency syndromes (1999) 2002;30(1):9-20.
2002: Susan E Shetzline; Camille Martinand-Mari; Nancy L Reichenbach; Zivjena Buletic; Bernard Lebleu; Wolfgang Pfleiderer; Ramamurthy Charubala; Kenny De Meirleir; Pascale De Becker; Daniel L Peterson; C Vincent Herst; Patrick Englebienne; Robert J Suhadolnik
Structural and functional features of the 37-kDa 2-5A-dependent RNase L in chronic fatigue syndrome.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2002;22(4):443-56.
2001: S E Shetzline; Robert J Suhadolnik
Characterization of a 2',5'-oligoadenylate (2-5A)-dependent 37-kDa RNase L: azido photoaffinity labeling and 2-5A-dependent activation.
The Journal of biological chemistry 2001;276(26):23707-11.
1999: NF Muto; Camille Martinand-Mari; ME Adelson; Robert J Suhadolnik
Inhibition of replication of reactivated human immunodeficiency virus type 1 (HIV-1) in latently infected U1 cells transduced with an HIV-1 long terminal repeat-driven PKR cDNA construct.
Journal of virology 1999;73(11):9021-8.
1999: ME Adelson; Camille Martinand-Mari; KT Iacono; NF Muto; Robert J Suhadolnik
Inhibition of human immunodeficiency virus (HIV-1) replication in SupT1 cells transduced with an HIV-1 LTR-driven PKR cDNA construct.
European journal of biochemistry / FEBS 1999;264(3):806-15.
1999: E I Kvasyuk; Igor Alexander Mikhailopulo; Robert J Suhadolnik; Earl E Henderson; NF Muto; KT Iacono; J Homon; Wolfgang Pfleiderer
Synthesis and biological activity of 2',5'-oligoadenylate trimers containing 5'-terminal 5'-amino-5'-deoxy- and 5'-amino-3',5'-dideoxyadenosine derivatives.
Nucleosides & nucleotides 1999;18(6-7):1483-4.
1997: Robert J Suhadolnik; D L Peterson; K O'Brien; P R Cheney; C Vincent Herst; Nancy L Reichenbach; N Kon; S E Horvath; KT Iacono; ME Adelson; Kenny De Meirleir; Pascale De Becker; Ramamurthy Charubala; Wolfgang Pfleiderer
Biochemical evidence for a novel low molecular weight 2-5A-dependent RNase L in chronic fatigue syndrome.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1997;17(7):377-85.
1996: N Kon; Robert J Suhadolnik
Identification of the ATP binding domain of recombinant human 40-kDa 2',5'-oligoadenylate synthetase by photoaffinity labeling with 8-azido-[alpha-32P]ATP.
The Journal of biological chemistry 1996;271(33):19983-90.
1996: Keith E Latham; Stephen C Cosenza; N L Reichenbach; E Mordechai; M E Adelson; N Kon; S E Horvath; R Charubala; Sergey N Mikhailov; W Pfeiderer; Robert J Suhadolnik
Inhibition of growth of estrogen receptor positive and estrogen receptor negative breast cancer cells in culture by AA-etherA, a stable 2-5A derivative.
Oncogene 1996;12(4):827-37.
1995: E Mordechai; N Kon; Earl E Henderson; Robert J Suhadolnik
Activation of the interferon-inducible enzymes, 2',5'-oligoadenylate synthetase and PKR by human T-cell leukemia virus type I Rex-response element.
Virology 1995;206(2):913-22.
1995: R J Fingerote; B M Cruz; R M Gorczynski; L S Fung; H R Hubbell; Robert J Suhadolnik; G A Levy
A 2',5'-oligoadenylate analogue inhibits murine hepatitis virus strain 3 (MHV-3) replication in vitro but does not reduce MHV-3-related mortality or induction of procoagulant activity in susceptible mice.
The Journal of general virology 1995;76 ( Pt 2)():373-80.
1994: Robert J Suhadolnik; N L Reichenbach; P Hitzges; M E Adelson; D L Peterson; P Cheney; P Salvato; C Thompson; M Loveless; W E Müller
Changes in the 2-5A synthetase/RNase L antiviral pathway in a controlled clinical trial with poly(I)-poly(C12U) in chronic fatigue syndrome.
In vivo (Athens, Greece) 1994;8(4):599-604.
1994: Dharam V Ablashi; Z N Berneman; M Williams; D R Strayer; B Kramarsky; Robert J Suhadolnik; N Reichenbach; P Hiltzges; A L Komaroff
Ampligen inhibits human herpesvirus-6 in vitro.
In vivo (Athens, Greece) 1994;8(4):587-91.
1994: H R Hubbell; K Kariko; Robert J Suhadolnik; I Brodsky
RNase L and increased endoribonuclease activities in the mononuclear cells of patients with chronic myelogenous leukemia.
Anticancer research 1994;14(2A):341-6.
1994: Heinz C Schröder; M Kelve; H Schäcke; Wolfgang Pfleiderer; R Charubala; Robert J Suhadolnik; W E Müller
Inhibition of DNA topoisomerase I activity by 2',5'-oligoadenylates and mismatched double-stranded RNA in uninfected and HIV-1-infected H9 cells.
Chemico-biological interactions 1994;90(2):169-83.
1994: Robert J Suhadolnik; N L Reichenbach; P Hitzges; Robert W Sobol; D L Peterson; B Henry; Dharam V Ablashi; W E Müller; Heinz C Schröder; W A Carter
Upregulation of the 2-5A synthetase/RNase L antiviral pathway associated with chronic fatigue syndrome.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1994;18 Suppl 1():S96-104.
1994: Robert J Suhadolnik
Photolabeling of the enzymes of the 2-5A synthetase/RNase L/p68 kinase antiviral systems with azido probes.
Progress in molecular and subcellular biology 1994;14():260-75.
1993: Robert W Sobol; W L Fisher; N L Reichenbach; A Kumar; W A Beard; Samuel H Wilson; R Charubala; Wolfgang Pfleiderer; Robert J Suhadolnik
HIV-1 reverse transcriptase: inhibition by 2',5'-oligoadenylates.
Biochemistry 1993;32(45):12112-8.
1993: A Kumar; H R Kim; Robert W Sobol; S Patricia Becerra; B J Lee; D L Hatfield; Robert J Suhadolnik; Samuel H Wilson
Mapping of nucleic acid binding in proteolytic domains of HIV-1 reverse transcriptase.
Biochemistry 1993;32(29):7466-74.
1993: W A Carter; Robert J Suhadolnik; W E Müller; B E Korba; H R Hubbell; G Garcia; D R Strayer
Specific RNA drug therapy of hepatitis viruses.
Annals of the New York Academy of Sciences 1993;685():758-61.
1993: Robert J Suhadolnik; N L Reichenbach; P M Hitzges; Dharam V Ablashi; D R Strayer; W A Carter
RNA drug therapy acting via the 2-5A synthetase/RNase L pathway.
Annals of the New York Academy of Sciences 1993;685():756-7.
1993: Robert W Sobol; R Charubala; Wolfgang Pfleiderer; Robert J Suhadolnik
Chemical synthesis and biological characterization of phosphorothioate analogs of 2', 5'-3'-deoxyadenylate trimer.
Nucleic acids research 1993;21(10):2437-43.
1992: D S Haines; Robert J Suhadolnik; H R Hubbell; D H Gillespie
Cellular and enzymatic activities of a synthetic heteropolymer double-stranded RNA of defined size.
The Journal of biological chemistry 1992;267(26):18315-9.
1992: Heinz C Schröder; Robert J Suhadolnik; Wolfgang Pfleiderer; R Charubala; W E Müller
(2'-5')Oligoadenylate and intracellular immunity against retrovirus infection.
The International journal of biochemistry 1992;24(1):55-63.
1991: Robert W Sobol; Robert J Suhadolnik; A Kumar; B J Lee; D L Hatfield; Samuel H Wilson
Localization of a polynucleotide binding region in the HIV-1 reverse transcriptase: implications for primer binding.
Biochemistry 1991;30(44):10623-31.
1991: H R Hubbell; P C Sheetz; S S Iogal; Irina Brodsky; K Kariko; S W Li; Robert J Suhadolnik; Robert W Sobol
Heterogeneous nuclear RNA from hairy cell leukemia patients activates 2',5'-oligoadenylate synthetase.
Anticancer research 1991;11(5):1927-32.
1991: W E Müller; B E Weiler; R Charubala; Wolfgang Pfleiderer; L Leserman; Robert W Sobol; Robert J Suhadolnik; Heinz C Schröder
Cordycepin analogues of 2',5'-oligoadenylate inhibit human immunodeficiency virus infection via inhibition of reverse transcriptase.
Biochemistry 1991;30(8):2027-33.
1990: Robert J Suhadolnik; S W Li; Robert W Sobol; J M Varnum
2',5' A synthetase: allosteric activation by fructose 1,6-bisphosphate.
Biochemical and biophysical research communications 1990;169(3):1198-203.
1990: S W Li; J J Moskow; Robert J Suhadolnik
8-Azido double-stranded RNA photoaffinity probes. Enzymatic synthesis, characterization, and biological properties of poly(I,8-azidoI).poly(C) and poly(I,8-azidoI).poly(C12U) with 2',5'-oligoadenylate synthetase and protein kinase.
The Journal of biological chemistry 1990;265(10):5470-4.
1990: G Charachon; Robert W Sobol; Catherine Bisbal; Tamim Salehzada; Michelle Silhol; R Charubala; Wolfgang Pfleiderer; Bernard Lebleu; Robert J Suhadolnik
Phosphorothioate analogues of (2'-5')(A)4: agonist and antagonist activities in intact cells.
Biochemistry 1990;29(10):2550-6.
1989: D C Montefiori; Robert W Sobol; S W Li; N L Reichenbach; Robert J Suhadolnik; R Charubala; Wolfgang Pfleiderer; A Modliszewski; W Edward Robinson; W M Mitchell
Phosphorothioate and cordycepin analogues of 2',5'-oligoadenylate: inhibition of human immunodeficiency virus type 1 reverse transcriptase and infection in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(18):7191-4.
1989: Robert J Suhadolnik; S Pornbanlualap; D C Baker; K N Tiwari; A K Hebbler
Stereospecific 2'-amination and 2'-chlorination of adenosine by Actinomadura in the biosynthesis of 2'-amino-2'-deoxyadenosine and 2'-chloro-2'-deoxycoformycin.
Archives of biochemistry and biophysics 1989;270(1):374-82.
1989: Robert J Suhadolnik; S Pornbanlualap; J M Wu; D C Baker; A K Hebbler
Biosynthesis of 9-beta-D-arabinofuranosyladenine: hydrogen exchange at C-2' and oxygen exchange at C-3' of adenosine.
Archives of biochemistry and biophysics 1989;270(1):363-73.
1988: Robert J Suhadolnik; K Karikó; Robert W Sobol; S W Li; N L Reichenbach; B E Haley
2- and 8-azido photoaffinity probes. 1. Enzymatic synthesis, characterization, and biological properties of 2- and 8-azido photoprobes of 2-5A and photolabeling of 2-5A binding proteins.
Biochemistry 1988;27(24):8840-6.
1988: Robert J Suhadolnik; S W Li; Robert W Sobol; B E Haley
2- and 8-azido photoaffinity probes. 2. Studies on the binding process of 2-5A synthetase by photosensitive ATP analogues.
Biochemistry 1988;27(24):8846-51.
1988: J C Hanvey; E S Hawkins; D C Baker; Robert J Suhadolnik
8-Ketodeoxycoformycin and 8-ketocoformycin as intermediates in the biosynthesis of 2'-deoxycoformycin and coformycin.
Biochemistry 1988;27(15):5790-5.
1988: G E Fronko; Robert J Suhadolnik; Eric Vonderheid; K Karikó; N L Reichenbach; Kenneth D Chavin; Earl E Henderson
Decreased Epstein-Barr virus-induced transformation, and elevated 2-5A synthetase and RNase L activity in peripheral blood mononuclear cells from patients treated with recombinant interferon alfa 2b.
Biochemical and biophysical research communications 1988;153(1):448-53.
1987: Robert J Suhadolnik; C Lee; K Karikó; S W Li
Phosphorothioate analogues of 2',5'-oligoadenylate. Enzymatic synthesis, properties, and biological activities of 2',5'-phosphorothioates from adenosine 5'-O-(2-thiotriphosphate) and adenosine 5'-O-(3-thiotriphosphate).
Biochemistry 1987;26(22):7143-9.
1987: K Karikó; S W Li; Robert W Sobol; Robert J Suhadolnik; R Charubala; Wolfgang Pfleiderer
Phosphorothioate analogues of 2',5'-oligoadenylate. Activation of 2',5'-oligoadenylate-dependent endoribonuclease by 2',5'-phosphorothioate cores and 5'-monophosphates.
Biochemistry 1987;26(22):7136-42.
1987: K Karikó; Robert W Sobol; L Suhadolnik; S W Li; N L Reichenbach; Robert J Suhadolnik; R Charubala; Wolfgang Pfleiderer
Phosphorothioate analogues of 2',5'-oligoadenylate. Enzymatically synthesized 2',5'-phosphorothioate dimer and trimer: unequivocal structural assignment and activation of 2',5'-oligoadenylate-dependent endoribonuclease.
Biochemistry 1987;26(22):7127-35.
1987: J C Hanvey; E S Hawkins; J B Tunac; J J Dechter; D C Baker; Robert J Suhadolnik
Biosynthesis of 2'-deoxycoformycin: evidence for ring expansion of the adenine moiety of adenosine to a tetrahydroimidazo[4,5-d][1,3]diazepine system.
Biochemistry 1987;26(18):5636-41.
1986: Y Devash; Robert J Suhadolnik; I Sela
Measurement of effect of (2'-5')-oligoadenylates and analogs on tobacco mosaic virus replication.
Methods in enzymology 1986;119():759-61.
1986: Robert J Suhadolnik; C Lee; D H Willis
Measurement of effect of (2'-5')-oligoadenylates and analogs on protein synthesis and growth of cells.
Methods in enzymology 1986;119():667-75.
1986: Y Devash; I Sela; Robert J Suhadolnik
Enzymatic synthesis of plant oligoadenylates in vitro.
Methods in enzymology 1986;119():752-8.
1985: H R Hubbell; E C Pequignot; D H Willis; C Lee; Robert J Suhadolnik
Differential antiproliferative actions of 2',5' oligo A trimer core and its cordycepin analogue on human tumor cells.
International journal of cancer. Journal international du cancer 1985;36(3):389-94.
1985: Y Devash; M Reichman; I Sela; N L Reichenbach; Robert J Suhadolnik
Plant oligoadenylates: enzymatic synthesis, isolation, and biological activities.
Biochemistry 1985;24(3):593-9.
1985: Robert J Suhadolnik; N L Reichenbach; C Lee; D R Strayer; I Brodsky; W A Carter
Ampligen treatment of renal cell carcinoma: changes in 2-5A synthetase, 2-5A oligomer size and natural killer cell activity associated with antitumor response clinically.
Progress in clinical and biological research 1985;202():449-56.
1984: P L Black; Earl E Henderson; Wolfgang Pfleiderer; R Charubala; Robert J Suhadolnik
2',5'-Oligoadenylate trimer core and the cordycepin analog augment the tumoricidal activity of human natural killer cells.
Journal of immunology (Baltimore, Md. : 1950) 1984;133(5):2773-7.
1984: Robert J Suhadolnik; Y Sawada; J Gabriel; N L Reichenbach; Earl E Henderson
Accumulation of low molecular weight DNA and changes in chromatin structure in HeLa cells treated with human fibroblast interferon.
The Journal of biological chemistry 1984;259(8):4764-9.
1984: Eric Vonderheid; Robert J Suhadolnik; E L Sobel; M B Flick; Joseph Mosca
Increased 2',5'-oligoadenylate synthetase activity in blood mononuclear leukocytes from patients with advanced cutaneous T-cell lymphoma.
Clinical immunology and immunopathology 1984;31(1):138-50.
1984: Y Devash; A Gera; D H Willis; M Reichman; Wolfgang Pfleiderer; R Charubala; I Sela; Robert J Suhadolnik
5'-dephosphorylated 2',5'-adenylate trimer and its analogs. Inhibition of tobacco mosaic virus replication in tobacco mosaic virus-infected leaf discs, protoplasts, and intact tobacco plants.
The Journal of biological chemistry 1984;259(6):3482-6.
1984: J C Hanvey; J K Hardman; Robert J Suhadolnik; D C Baker
Evidence for the conversion of adenosine to 2'-deoxycoformycin by Streptomyces antibioticus.
Biochemistry 1984;23(5):904-7.
1983: Robert J Suhadolnik; Y Sawada; M B Flick; N L Reichenbach; Joseph Mosca
Effect of human fibroblast interferon on the antiviral activity of mammalian cells treated with bleomycin, vincristine, or mitomycin C.
Cancer research 1983;43(11):5462-6.
1983: Robert J Suhadolnik; M B Flick; Joseph Mosca; Y Sawada; Paul W. Doetsch; Eric Vonderheid
2',5'-oligoadenylate synthetase from cutaneous T-cell lymphoma: biosynthesis, identification, quantitation, molecular size of the 2',5'-oligoadenylates, and inhibition of protein synthesis.
Biochemistry 1983;22(17):4153-8.
1983: Robert J Suhadolnik; Y Devash; N L Reichenbach; M B Flick; J M Wu
Enzymatic synthesis of the 2',5'-A4 tetramer analog, 2',5'-ppp3'dA(p3'dA)3, by rabbit reticulocyte lysates: binding and activation of the 2',5'-A eta dependent nuclease, hydrolysis of mRNA, and inhibition of protein synthesis.
Biochemical and biophysical research communications 1983;111(1):205-12.
1983: Joseph Mosca; J M Wu; Robert J Suhadolnik
Restoration of protein synthesis in lysed rabbit reticulocytes by the enzymatic removal of adenosine 5'-monophosphate with either AMP deaminase or AMP nucleosidase.
Biochemistry 1983;22(2):346-54.
1982: Earl E Henderson; Paul W. Doetsch; R Charubala; Wolfgang Pfleiderer; Robert J Suhadolnik
Inhibition of Epstein-Barr virus-associated nuclear antigen (EBNA) induction by (2',5')oligoadenylate and the cordycepin analog: mechanism of action for inhibition of EBV-induced transformation.
Virology 1982;122(1):198-201.
1981: Robert J Suhadolnik; N L Reichenbach
Glutamate as the common precursor for the aglycon of the naturally occurring C-nucleoside antibiotics.
Biochemistry 1981;20(24):7042-6.
1981: Paul W. Doetsch; Robert J Suhadolnik; Y Sawada; Joseph Mosca; M B Flick; N L Reichenbach; A Q Dang; J M Wu; R Charubala; Wolfgang Pfleiderer; Earl E Henderson
Core (2'-5')oligoadenylate and the cordycepin analog: inhibitors of Epstein--Barr virus-induced transformation of human lymphocytes in the absence of interferon.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(11):6699-703.
1981: Paul W. Doetsch; J M Wu; Y Sawada; Robert J Suhadolnik
Synthesis and characterization of (2'-5')ppp3'dA(p3'dA)n, an analogue of (2'-5')pppA(pA)n.
Nature 1981;291(5813):355-8.
1981: Robert J Suhadolnik; Paul W. Doetsch; J M Wu; Y Sawada; Joseph Mosca; N L Reichenbach
Enzymic synthesis of (2'-5')ppp3'dA(p3'dA)n, the cordycepin analog of (2'-5')-oligoadenylic acid.
Methods in enzymology 1981;79(Pt B):257-65.