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Li Sun

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Xueyan Wang; Phuong Le; Congxin Liang; Julie Chan; David Kiewlich; Todd Miller; Dave Harris; Li Sun; Audie Rice; Stefan Vasile; Robert Blake; Anthony R Howlett; Neela Patel; Gerald McMahon; Kenneth E Lipson
Potent and selective inhibitors of the Met [hepatocyte growth factor/scatter factor (HGF/SF) receptor] tyrosine kinase block HGF/SF-induced tumor cell growth and invasion.
Neela Patel; Li Sun; Deborah Moshinsky; Hui Chen; Kathleen M Leahy; Phuong Le; Katherine G Moss; Xueyan Wang; Audie Rice; Danny Tam; A Douglas Laird; Xiaoming Yu; Qingling Zhang; Cho Tang; Gerald McMahon; Anthony R Howlett
A selective and oral small molecule inhibitor of vascular epithelial growth factor receptor (VEGFR)-2 and VEGFR-1 inhibits neovascularization and vascular permeability.
Dirk B Mendel; A Douglas Laird; Xiaohua Xin; Sharianne G Louie; James G Christensen; Guangmin Li; Randall E Schreck; Tinya J Abrams; Theresa J Ngai; Leslie B Lee; Lesley J Murray; Jeremy Carver; Emily Chan; Katherine G Moss; Joshua O Haznedar; Juthamas Sukbuntherng; Robert Blake; Li Sun; Cho Tang; Todd Miller; Sheri Shirazian; Gerald McMahon; Julie M Cherrington
In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship.

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All Publications

2003: Xueyan Wang; Phuong Le; Congxin Liang; Julie Chan; David Kiewlich; Todd Miller; Dave Harris; Li Sun; Audie Rice; Stefan Vasile; Robert Blake; Anthony R Howlett; Neela Patel; Gerald McMahon; Kenneth E Lipson
Potent and selective inhibitors of the Met [hepatocyte growth factor/scatter factor (HGF/SF) receptor] tyrosine kinase block HGF/SF-induced tumor cell growth and invasion.
Molecular cancer therapeutics 2003;2(11):1085-92.
2003: Neela Patel; Li Sun; Deborah Moshinsky; Hui Chen; Kathleen M Leahy; Phuong Le; Katherine G Moss; Xueyan Wang; Audie Rice; Danny Tam; A Douglas Laird; Xiaoming Yu; Qingling Zhang; Cho Tang; Gerald McMahon; Anthony R Howlett
A selective and oral small molecule inhibitor of vascular epithelial growth factor receptor (VEGFR)-2 and VEGFR-1 inhibits neovascularization and vascular permeability.
The Journal of pharmacology and experimental therapeutics 2003;306(3):838-45.
2003: Dirk B Mendel; A Douglas Laird; Xiaohua Xin; Sharianne G Louie; James G Christensen; Guangmin Li; Randall E Schreck; Tinya J Abrams; Theresa J Ngai; Leslie B Lee; Lesley J Murray; Jeremy Carver; Emily Chan; Katherine G Moss; Joshua O Haznedar; Juthamas Sukbuntherng; Robert Blake; Li Sun; Cho Tang; Todd Miller; Sheri Shirazian; Gerald McMahon; Julie M Cherrington
In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(1):327-37.
2002: Li Sun; Jean Cui; Congxin Liang; Yong Zhou; Asaad Nematalla; Xueyan Wang; Hui Chen; Cho Tang; James Wei
Rational design of 4,5-disubstituted-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-ones as a novel class of inhibitors of epidermal growth factor receptor (EGF-R) and Her2(p185(erbB)) tyrosine kinases.
Bioorganic & medicinal chemistry letters 2002;12(16):2153-7.
2001: James G Christensen; Randall E Schreck; Emily Chan; Xueyan Wang; C Yang; L Liu; J Cui; Li Sun; J Wei; Julie M Cherrington; Dirk B Mendel
High levels of HER-2 expression alter the ability of epidermal growth factor receptor (EGFR) family tyrosine kinase inhibitors to inhibit EGFR phosphorylation in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(12):4230-8.
2001: Geoffrey W Krystal; S Honsawek; David Kiewlich; Congxin Liang; Stefan Vasile; Li Sun; Gerald McMahon; Kenneth E Lipson
Indolinone tyrosine kinase inhibitors block Kit activation and growth of small cell lung cancer cells.
Cancer research 2001;61(9):3660-8.
2000: Robert Blake; Martin A Broome; Xiangdong Liu; J Wu; M Gishizky; Li Sun; SA Courtneidge
SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling.
Molecular and cellular biology 2000;20(23):9018-27.
2000: A Douglas Laird; Peter Vajkoczy; Laura K Shawver; Andreas Thurnher; Congxin Liang; M Mohammadi; J Schlessinger; Axel Ullrich; Stevan Hubbard; Robert Blake; TA Fong; LM Strawn; Li Sun; Cho Tang; R Hawtin; F Tang; Narmada Shenoy; KP Hirth; Gerald McMahon
SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors.
Cancer research 2000;60(15):4152-60.
2000: Li Sun; N Tran; Congxin Liang; S Hubbard; F Tang; Kenneth E Lipson; Randall E Schreck; Y Zhou; Gerald McMahon; Cho Tang
Identification of substituted 3-[(4,5,6, 7-tetrahydro-1H-indol-2-yl)methylene]-1,3-dihydroindol-2-ones as growth factor receptor inhibitors for VEGF-R2 (Flk-1/KDR), FGF-R1, and PDGF-Rbeta tyrosine kinases.
Journal of medicinal chemistry 2000;43(14):2655-63.
1999: Li Sun; N Tran; Congxin Liang; F Tang; A Rice; Randall E Schreck; K Waltz; Laura K Shawver; Gerald McMahon; Cho Tang
Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases.
Journal of medicinal chemistry 1999;42(25):5120-30.
1999: TA Fong; Laura K Shawver; Li Sun; Cho Tang; H App; T J Powell; Y H Kim; Randall E Schreck; Xueyan Wang; W Risau; Axel Ullrich; KP Hirth; Gerald McMahon
SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types.
Cancer research 1999;59(1):99-106.
1998: Li Sun; N Tran; F Tang; H App; P Hirth; Gerald McMahon; Cho Tang
Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases.
Journal of medicinal chemistry 1998;41(14):2588-603.
1997: Moosa Mohammadi; Gerald McMahon; Li Sun; Cho Tang; P Hirth; Brian K Yeh; Stevan Hubbard; Joseph Schlessinger
Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors.
Science (New York, N.Y.) 1997;276(5314):955-60.