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Manickavasagam Sundaram

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Chemicals & Drugs

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Glycosylation

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Publications

TOP 3
Sylvia Y M Yao; Amy M L Ng; Mark F Vickers; Manickavasagam Sundaram; Carol E Cass; Stephen A Baldwin; James D Young
Functional and molecular characterization of nucleobase transport by recombinant human and rat equilibrative nucleoside transporters 1 and 2. Chimeric constructs reveal a role for the ENT2 helix 5-6 region in nucleobase translocation.
Manickavasagam Sundaram; Sylvia Y M Yao; Jean C Ingram; Z A Berry; Fatima Abidi; Carol E Cass; Stephen A Baldwin; James D Young
Topology of a human equilibrative, nitrobenzylthioinosine (NBMPR)-sensitive nucleoside transporter (hENT1) implicated in the cellular uptake of adenosine and anti-cancer drugs.
Manickavasagam Sundaram; Sylvia Y M Yao; Amy M L Ng; Carol E Cass; Stephen A Baldwin; James D Young
Equilibrative nucleoside transporters: mapping regions of interaction for the substrate analogue nitrobenzylthioinosine (NBMPR) using rat chimeric proteins.

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2002: Sylvia Y M Yao; Amy M L Ng; Mark F Vickers; Manickavasagam Sundaram; Carol E Cass; Stephen A Baldwin; James D Young
Functional and molecular characterization of nucleobase transport by recombinant human and rat equilibrative nucleoside transporters 1 and 2. Chimeric constructs reveal a role for the ENT2 helix 5-6 region in nucleobase translocation.
The Journal of biological chemistry 2002;277(28):24938-48.
2001: Manickavasagam Sundaram; Sylvia Y M Yao; Jean C Ingram; Z A Berry; Fatima Abidi; Carol E Cass; Stephen A Baldwin; James D Young
Topology of a human equilibrative, nitrobenzylthioinosine (NBMPR)-sensitive nucleoside transporter (hENT1) implicated in the cellular uptake of adenosine and anti-cancer drugs.
The Journal of biological chemistry 2001;276(48):45270-5.
2001: Manickavasagam Sundaram; Sylvia Y M Yao; Amy M L Ng; Carol E Cass; Stephen A Baldwin; James D Young
Equilibrative nucleoside transporters: mapping regions of interaction for the substrate analogue nitrobenzylthioinosine (NBMPR) using rat chimeric proteins.
Biochemistry 2001;40(27):8146-51.
2001: Sylvia Y M Yao; Amy M L Ng; Manickavasagam Sundaram; Carol E Cass; Stephen A Baldwin; James D Young
Transport of antiviral 3'-deoxy-nucleoside drugs by recombinant human and rat equilibrative, nitrobenzylthioinosine (NBMPR)-insensitive (ENT2) nucleoside transporter proteins produced in Xenopus oocytes.
Molecular membrane biology 2001;18(2):161-7.
2001: Sylvia Y M Yao; Manickavasagam Sundaram; Eugene G Chomey; Carol E Cass; Stephen A Baldwin; James D Young
Identification of Cys140 in helix 4 as an exofacial cysteine residue within the substrate-translocation channel of rat equilibrative nitrobenzylthioinosine (NBMPR)-insensitive nucleoside transporter rENT2.
The Biochemical journal 2001;353(Pt 2):387-93.
1999: Mark F Vickers; Rajam S Mani; Manickavasagam Sundaram; Douglas L Hogue; James D Young; Stephen A Baldwin; Carol E Cass
Functional production and reconstitution of the human equilibrative nucleoside transporter (hENT1) in Saccharomyces cerevisiae. Interaction of inhibitors of nucleoside transport with recombinant hENT1 and a glycosylation-defective derivative (hENT1/N48Q).
The Biochemical journal 1999;339 ( Pt 1)():21-32.
1998: Manickavasagam Sundaram; Sylvia Y M Yao; Amy M L Ng; Mark Griffiths; Carol E Cass; Stephen A Baldwin; James D Young
Chimeric constructs between human and rat equilibrative nucleoside transporters (hENT1 and rENT1) reveal hENT1 structural domains interacting with coronary vasoactive drugs.
The Journal of biological chemistry 1998;273(34):21519-25.