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Bokyung Sung

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Bokyung Sung; Vivek R Yadav; Sahdeo Prasad; Jayaraj Ravindran; Bharat B Aggarwal
Capsazepine, a TRPV1 antagonist, sensitizes colorectal cancer cells to apoptosis by TRAIL through ROS-JNK-CHOP-mediated upregulation of death receptors.
Sahdeo Prasad; Simone Reuter; Bokyung Sung; Caimiao Wei; Vivek R Yadav; Veerabhadran Baladandayuthapani; Amit Deorukhkar; Parmeswaran Diagaradjane; Sushovan Guha; Ramaswamy Kannappan; Sunil Krishnan; Bharat B Aggarwal
Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.
Mi-Ae Lyu; John W Marks; Lan V Pham; Bharat B Aggarwal; Kwang Seok Ahn; Lawrence H Cheung; Min-Jeong Cho; Richard J Ford; Walter N Hittelman; Bokyung Sung; Archito Tamayo; Michael G Rosenblum
The therapeutic effects of rGel/BLyS fusion toxin in in vitro and in vivo models of mantle cell lymphoma.

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All Publications

2012: Bokyung Sung; Vivek R Yadav; Sahdeo Prasad; Jayaraj Ravindran; Bharat B Aggarwal
Capsazepine, a TRPV1 antagonist, sensitizes colorectal cancer cells to apoptosis by TRAIL through ROS-JNK-CHOP-mediated upregulation of death receptors.
Free radical biology & medicine 2012;53(10):1977-87.
2012: Sahdeo Prasad; Simone Reuter; Bokyung Sung; Caimiao Wei; Vivek R Yadav; Veerabhadran Baladandayuthapani; Amit Deorukhkar; Parmeswaran Diagaradjane; Sushovan Guha; Ramaswamy Kannappan; Sunil Krishnan; Bharat B Aggarwal
Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(18):4942-53.
2012: Mi-Ae Lyu; John W Marks; Lan V Pham; Bharat B Aggarwal; Kwang Seok Ahn; Lawrence H Cheung; Min-Jeong Cho; Richard J Ford; Walter N Hittelman; Bokyung Sung; Archito Tamayo; Michael G Rosenblum
The therapeutic effects of rGel/BLyS fusion toxin in in vitro and in vivo models of mantle cell lymphoma.
Biochemical pharmacology 2012;84(4):451-8.
2012: Ajaikumar Kunnumakkara; Jayaraj Ravindran; Bokyung Sung; Zhimin Tong; Amit Deorukhkar; Sanjit Dey; Parmeswaran Diagaradjane; Juri G Gelovani; Sushovan Guha; Cemile Koca; Sunil Krishnan; Bharat B Aggarwal
Zyflamend suppresses growth and sensitizes human pancreatic tumors to gemcitabine in an orthotopic mouse model through modulation of multiple targets.
International journal of cancer. Journal international du cancer 2012;131(3):E292-303.
2012: Vivek R Yadav; Juri G Gelovani; Sushovan Guha; Sunil Krishnan; Sahdeo Prasad; Bokyung Sung; Bharat B Aggarwal
Boswellic acid inhibits growth and metastasis of human colorectal cancer in orthotopic mouse model by downregulating inflammatory, proliferative, invasive and angiogenic biomarkers.
International journal of cancer. Journal international du cancer 2012;130(9):2176-84.
2012: Ji Hye Kim; Byoungduck Park; Bokyung Sung; Subash C Gupta; Ramaswamy Kannappan; Bharat B Aggarwal
Zyflamend sensitizes tumor cells to TRAIL-induced apoptosis through up-regulation of death receptors and down-regulation of survival proteins: role of ROS-dependent CCAAT/enhancer-binding protein-homologous protein pathway.
Antioxidants & redox signaling 2012;16(5):413-27.
2012: Anupam Kumar; Santosh Kumar; Bokyung Sung; Jia Xu; Dihua Yu; Bharat B Aggarwal; Kapil Mehta
Evidence that GTP-binding domain but not catalytic domain of transglutaminase 2 is essential for epithelial-to-mesenchymal transition in mammary epithelial cells.
Breast cancer research : BCR 2012;14(1):R4.
2012: Bokyung Sung; Vivek R Yadav; Sahdeo Prasad; Bharat B Aggarwal
Cancer cell signaling pathways targeted by spice-derived nutraceuticals.
Nutrition and cancer 2012;64(2):173-97.
2011: Preetha Anand; Ajaikumar Kunnumakkara; Kallikat N Rajasekharan; Bokyung Sung; Bharat B Aggarwal
Suppression of pro-inflammatory and proliferative pathways by diferuloylmethane (curcumin) and its analogues dibenzoylmethane, dibenzoylpropane, and dibenzylideneacetone: role of Michael acceptors and Michael donors.
Biochemical pharmacology 2011;82(12):1901-9.
2011: Bharat B Aggarwal; Bokyung Sung
NF-κB in cancer: a matter of life and death.
Cancer discovery 2011;1(6):469-71.
2011: Byoungduck Park; Bokyung Sung; Vivek R Yadav; Madan M Chaturvedi; Bharat B Aggarwal
Triptolide, histone acetyltransferase inhibitor, suppresses growth and chemosensitizes leukemic cells through inhibition of gene expression regulated by TNF-TNFR1-TRADD-TRAF2-NIK-TAK1-IKK pathway.
Biochemical pharmacology 2011;82(9):1134-44.
2011: Bokyung Sung; Sung-Gook Cho; Mingyao Liu; Bharat B Aggarwal
Butein, a tetrahydroxychalcone, suppresses cancer-induced osteoclastogenesis through inhibition of receptor activator of nuclear factor-kappaB ligand signaling.
International journal of cancer. Journal international du cancer 2011;129(9):2062-72.
2011: Bharat B Aggarwal; Madan M Chaturvedi; Subash C Gupta; Ramaswamy Kannappan; Ji Hye Kim; Byoungduck Park; Kanokkarn Phromnoi; Sahdeo Prasad; Seema Prasad; Simone Reuter; Chitra Sundaram; Vivek R Yadev; Bokyung Sung
Identification of novel anti-inflammatory agents from Ayurvedic medicine for prevention of chronic diseases: "reverse pharmacology" and "bedside to bench" approach.
Current drug targets 2011;12(11):1595-653.
2011: Bokyung Sung; Vivek R Yadav; Afsaneh Lavasanifar; Sahdeo Prasad; Bharat B Aggarwal
Cancer and diet: How are they related?
Free radical research 2011;45(8):864-79.
2011: Byoungduck Park; Bokyung Sung; Vivek R Yadav; Sung Gook Cho; Mingyao Liu; Bharat B Aggarwal
Acetyl-11-keto-β-boswellic acid suppresses invasion of pancreatic cancer cells through the downregulation of CXCR4 chemokine receptor expression.
International journal of cancer. Journal international du cancer 2011;129(1):23-33.
2011: Bharat B Aggarwal; Bokyung Sung
The relationship between inflammation and cancer is analogous to that between fuel and fire.
Oncology (Williston Park, N.Y.) 2011;25(5):414-8.
2011: Kanokkarn Phromnoi; Simone Reuter; Bokyung Sung; Sahdeo Prasad; Ramaswamy Kannappan; Vivek R Yadav; Wisinee Chanmahasathien; Pornngarm Limtrakul; Bharat B Aggarwal
A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IκB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents.
Molecular pharmacology 2011;79(2):279-89.
2011: Byoungduck Park; Sahdeo Prasad; Bokyung Sung; Vivek Yadav; Bharat B Aggarwal
Boswellic acid suppresses growth and metastasis of human pancreatic tumors in an orthotopic nude mouse model through modulation of multiple targets.
PloS one 2011;6(10):e26943.
2010: Hareesh B. Nair; Bokyung Sung; Vivek R Yadav; Ramaswamy Kannappan; Madan M Chaturvedi; Bharat B Aggarwal
Delivery of antiinflammatory nutraceuticals by nanoparticles for the prevention and treatment of cancer.
Biochemical pharmacology 2010;80(12):1833-43.
2010: Vivek R Yadav; Bokyung Sung; Sahdeo Prasad; Ramaswamy Kannappan; Sung Gook Cho; Mingyao Liu; Madan M Chaturvedi; Bharat B Aggarwal
Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor.
Journal of molecular medicine (Berlin, Germany) 2010;88(12):1243-53.
2010: Bokyung Sung; Jayaraj Ravindran; Sahdeo Prasad; Manoj Pandey; Bharat B Aggarwal
Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.
The Journal of biological chemistry 2010;285(46):35418-27.
2010: Simone Reuter; Sahdeo Prasad; Kanokkarn Phromnoi; Jayaraj Ravindran; Bokyung Sung; Vivek R Yadav; Ramaswamy Kannappan; Madan M Chaturvedi; Bharat B Aggarwal
Thiocolchicoside exhibits anticancer effects through downregulation of NF-κB pathway and its regulated gene products linked to inflammation and cancer.
Cancer prevention research (Philadelphia, Pa.) 2010;3(11):1462-72.
2010: Ajaikumar Kunnumakkara; Bokyung Sung; Jayaraj Ravindran; Parmeswaran Diagaradjane; Amit Deorukhkar; Sanjit Dey; Cemile Koca; Vivek R Yadav; Zhimin Tong; Juri G Gelovani; Sushovan Guha; Sunil Krishnan; Bharat B Aggarwal
{Gamma}-tocotrienol inhibits pancreatic tumors and sensitizes them to gemcitabine treatment by modulating the inflammatory microenvironment.
Cancer research 2010;70(21):8695-705.
2010: Mi-Ae Lyu; Bokyung Sung; Lawrence H Cheung; John W Marks; Bharat B Aggarwal; Ricardo Aguiar; Michael G Rosenblum
The rGel/BLyS fusion toxin inhibits STAT3 signaling via down-regulation of interleukin-6 receptor in diffuse large B-cell lymphoma.
Biochemical pharmacology 2010;80(9):1335-42.
2010: Vivek R Yadav; Ramaswamy Kannappan; Sahdeo Prasad; Bokyung Sung; Bharat B Aggarwal
Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer.
Toxins 2010;2(10):2428-66.
2010: Kanokkarn Phromnoi; Simone Reuter; Bokyung Sung; Pornngarm Limtrakul; Bharat B Aggarwal
A Dihydroxy-pentamethoxyflavone from Gardenia obtusifolia suppresses proliferation and promotes apoptosis of tumor cells through modulation of multiple cell signaling pathways.
Anticancer research 2010;30(9):3599-610.
2010: Ramaswamy Kannappan; Jayaraj Ravindran; Sahdeo Prasad; Bokyung Sung; Vivek R Yadav; Simone Reuter; Madan M Chaturvedi; Bharat B Aggarwal
Gamma-tocotrienol promotes TRAIL-induced apoptosis through reactive oxygen species/extracellular signal-regulated kinase/p53-mediated upregulation of death receptors.
Molecular cancer therapeutics 2010;9(8):2196-207.
2010: Manoj Pandey; Bokyung Sung; Bharat B Aggarwal
Betulinic acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP-1 in human multiple myeloma cells.
International journal of cancer. Journal international du cancer 2010;127(2):282-92.
2010: Jayaraj Ravindran; Gottumukkala V Subbaraju; Modukuri V Ramani; Bokyung Sung; Bharat B Aggarwal
Bisdemethylcurcumin and structurally related hispolon analogues of curcumin exhibit enhanced prooxidant, anti-proliferative and anti-inflammatory activities in vitro.
Biochemical pharmacology 2010;79(11):1658-66.
2010: Jayaraj Ravindran; Hareesh B. Nair; Bokyung Sung; Sahdeo Prasad; Rajeshwar Tekmal; Bharat B Aggarwal
Thymoquinone poly (lactide-co-glycolide) nanoparticles exhibit enhanced anti-proliferative, anti-inflammatory, and chemosensitization potential.
Biochemical pharmacology 2010;79(11):1640-7.
2010: Kuzhuvelil B Harikumar; Bokyung Sung; Sheeja T Tharakan; Manoj Pandey; Beena Joy; Sushovan Guha; Sunil Krishnan; Bharat B Aggarwal
Sesamin manifests chemopreventive effects through the suppression of NF-kappa B-regulated cell survival, proliferation, invasion, and angiogenic gene products.
Molecular cancer research : MCR 2010;8(5):751-61.
2010: Mi-Ae Lyu; Deepak Rai; Kwang Seok Ahn; Bokyung Sung; Lawrence H Cheung; John W Marks; Bharat B Aggarwal; Ricardo Aguiar; Varsha Gandhi; Michael G Rosenblum
The rGel/BLyS fusion toxin inhibits diffuse large B-cell lymphoma growth in vitro and in vivo.
Neoplasia (New York, N.Y.) 2010;12(5):366-75.
2010: Kuzhuvelil B Harikumar; Ajaikumar Kunnumakkara; Nobuo Ochi; Zhimin Tong; Amit Deorukhkar; Bokyung Sung; Lloyd Kelland; Stephen Jamieson; Rachel Sutherland; Tony Raynham; Mark Charles; Azadeh Bagherzadeh; Azadeh Bagherazadeh; Caroline Foxton; Alexandra Boakes; Muddasar Farooq; Dipen Maru; Parmeswaran Diagaradjane; Yoichi Matsuo; James Sinnett-Smith; Juri G Gelovani; Sunil Krishnan; Bharat B Aggarwal; Enrique Rozengurt; Christopher R Ireson; Sushovan Guha
A novel small-molecule inhibitor of protein kinase D blocks pancreatic cancer growth in vitro and in vivo.
Molecular cancer therapeutics 2010;9(5):1136-46.
2010: Kuzhuvelil B Harikumar; Bokyung Sung; Manoj Pandey; Sushovan Guha; Sunil Krishnan; Bharat B Aggarwal
Escin, a pentacyclic triterpene, chemosensitizes human tumor cells through inhibition of nuclear factor-kappaB signaling pathway.
Molecular pharmacology 2010;77(5):818-27.
2010: Bokyung Sung; Kwang Seok Ahn; Bharat B Aggarwal
Noscapine, a benzylisoquinoline alkaloid, sensitizes leukemic cells to chemotherapeutic agents and cytokines by modulating the NF-kappaB signaling pathway.
Cancer research 2010;70(8):3259-68.
2010: Bokyung Sung; Byoungduck Park; Vivek R Yadav; Bharat B Aggarwal
Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors.
The Journal of biological chemistry 2010;285(15):11498-507.
2010: Preetha Anand; Hareesh B. Nair; Bokyung Sung; Ajaikumar Kunnumakkara; Vivek R Yadav; Rajeshwar Tekmal; Bharat B Aggarwal
Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo.
Biochemical pharmacology 2010;79(3):330-8.
2010: Santosh K Sandur; Manoj Pandey; Bokyung Sung; Bharat B Aggarwal
5-hydroxy-2-methyl-1,4-naphthoquinone, a vitamin K3 analogue, suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase, SHP-1: potential role in chemosensitization.
Molecular cancer research : MCR 2010;8(1):107-18.
2009: Ashish M Kamat; Sheeja T Tharakan; Bokyung Sung; Bharat B Aggarwal
Curcumin potentiates the antitumor effects of Bacillus Calmette-Guerin against bladder cancer through the downregulation of NF-kappaB and upregulation of TRAIL receptors.
Cancer research 2009;69(23):8958-66.
2009: Supachai Yodkeeree; Bokyung Sung; Pornngarm Limtrakul; Bharat B Aggarwal
Zerumbone enhances TRAIL-induced apoptosis through the induction of death receptors in human colon cancer cells: Evidence for an essential role of reactive oxygen species.
Cancer research 2009;69(16):6581-9.
2009: Bharat B Aggarwal; Ajaikumar Kunnumakkara; Kuzhuvelil B Harikumar; Shan R Gupta; Sheeja T Tharakan; Cemile Koca; Sanjit Dey; Bokyung Sung
Signal transducer and activator of transcription-3, inflammation, and cancer: how intimate is the relationship?.
Annals of the New York Academy of Sciences 2009;1171():59-76.
2009: Bharat B Aggarwal; Michelle E Van Kuiken; Laxmi H Iyer; Kuzhuvelil B Harikumar; Bokyung Sung
Molecular targets of nutraceuticals derived from dietary spices: potential role in suppression of inflammation and tumorigenesis.
Experimental biology and medicine (Maywood, N.J.) 2009;234(8):825-49.
2009: Yoichi Matsuo; Paul M Campbell; Rolf A Brekken; Bokyung Sung; Michel M Ouellette; Jason Fleming; Bharat B Aggarwal; Channing J Der; Sushovan Guha
K-Ras promotes angiogenesis mediated by immortalized human pancreatic epithelial cells through mitogen-activated protein kinase signaling pathways.
Molecular cancer research : MCR 2009;7(6):799-808.
2009: Bokyung Sung; Ajaikumar Kunnumakkara; Gautam Sethi; Preetha Anand; Sushovan Guha; Bharat B Aggarwal
Curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model.
Molecular cancer therapeutics 2009;8(4):959-70.
2009: Manoj Pandey; Bokyung Sung; Kwang Seok Ahn; Bharat B Aggarwal
Butein suppresses constitutive and inducible signal transducer and activator of transcription (STAT) 3 activation and STAT3-regulated gene products through the induction of a protein tyrosine phosphatase SHP-1.
Molecular pharmacology 2009;75(3):525-33.
2009: Bokyung Sung; Akira Murakami; Babatunde Oyajobi; Bharat B Aggarwal
Zerumbone abolishes RANKL-induced NF-kappaB activation, inhibits osteoclastogenesis, and suppresses human breast cancer-induced bone loss in athymic nude mice.
Cancer research 2009;69(4):1477-84.
2009: Bharat B Aggarwal; Bokyung Sung
Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets.
Trends in pharmacological sciences 2009;30(2):85-94.
2009: Bharat B Aggarwal; R V Vijayalekshmi; Bokyung Sung
Targeting inflammatory pathways for prevention and therapy of cancer: short-term friend, long-term foe.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(2):425-30.
2009: Gautam Sethi; Bokyung Sung; Bharat B Aggarwal
Therapeutic Potential of VEGI/TL1A in Autoimmunity and Cancer.
Advances in experimental medicine and biology 2009;647():207-15.
2009: Gautam Sethi; Bokyung Sung; Ajaikumar B Kunnumakkara; Bharat B Aggarwal
Targeting TNF for Treatment of Cancer and Autoimmunity.
Advances in experimental medicine and biology 2009;647():37-51.
2009: Ajaikumar B Kunnumakkara; Asha S Nair; Bokyung Sung; Manoj Pandey; Bharat B Aggarwal
Boswellic acid blocks signal transducers and activators of transcription 3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase SHP-1.
Molecular cancer research : MCR 2009;7(1):118-28.
2008: Preetha Anand; Sherin G Thomas; Ajaikumar Kunnumakkara; Chitra Sundaram; Kuzhuvelil B Harikumar; Bokyung Sung; Sheeja T Tharakan; Krishna Misra; Indira K Priyadarsini; Kallikat N Rajasekharan; Bharat B Aggarwal
Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature.
Biochemical pharmacology 2008;76(11):1590-611.
2008: Gautam Sethi; Kwang Seok Ahn; Bokyung Sung; Ajaikumar Kunnumakkara; Madan M Chaturvedi; Bharat B Aggarwal
SH-5, an AKT inhibitor potentiates apoptosis and inhibits invasion through the suppression of anti-apoptotic, proliferative and metastatic gene products regulated by IkappaBalpha kinase activation.
Biochemical pharmacology 2008;76(11):1404-16.
2008: Bokyung Sung; Sonia Jhurani; Kwang Seok Ahn; Yoichi Mastuo; Tingfang Yi; Sushovan Guha; Mingyao Liu; Bharat B Aggarwal
Zerumbone down-regulates chemokine receptor CXCR4 expression leading to inhibition of CXCL12-induced invasion of breast and pancreatic tumor cells.
Cancer research 2008;68(21):8938-44.
2008: Bharat B Aggarwal; Ajaikumar Kunnumakkara; Kuzhuvelil B Harikumar; Sheeja T Tharakan; Bokyung Sung; Preetha Anand
Potential of spice-derived phytochemicals for cancer prevention.
Planta medica 2008;74(13):1560-9.
2008: Preetha Anand; Ajaikumar B Kunnumakkara; Ajaikumar B Kunnumakara; Chitra Sundaram; Kuzhuvelil B Harikumar; Sheeja T Tharakan; Oiki S Lai; Bokyung Sung; Bharat B Aggarwal
Cancer is a preventable disease that requires major lifestyle changes.
Pharmaceutical research 2008;25(9):2097-116.
2008: Zhimin Tong; Ajaikumar Kunnumakkara; Huamin Wang; Yoichi Matsuo; Parmeswaran Diagaradjane; Kuzhuvelil B Harikumar; Vijaya Ramachandran; Bokyung Sung; Arup Chakraborty; Robert S Bresalier; Craig D Logsdon; Bharat B Aggarwal; Sunil Krishnan; Sushovan Guha
Neutrophil gelatinase-associated lipocalin: a novel suppressor of invasion and angiogenesis in pancreatic cancer.
Cancer research 2008;68(15):6100-8.
2008: Manoj Pandey; Bokyung Sung; Ajaikumar Kunnumakkara; Gautam Sethi; Madan M Chaturvedi; Bharat B Aggarwal
Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis.
Cancer research 2008;68(13):5370-9.
2008: Gautam Sethi; Kwang Seok Ahn; Bokyung Sung; Bharat B Aggarwal
Pinitol targets nuclear factor-kappaB activation pathway leading to inhibition of gene products associated with proliferation, apoptosis, invasion, and angiogenesis.
Molecular cancer therapeutics 2008;7(6):1604-14.
2008: Kwang Seok Ahn; Gautam Sethi; Bokyung Sung; Ajay Goel; Ranju Ralhan; Bharat B Aggarwal
Guggulsterone, a farnesoid X receptor antagonist, inhibits constitutive and inducible STAT3 activation through induction of a protein tyrosine phosphatase SHP-1.
Cancer research 2008;68(11):4406-15.
2008: Bokyung Sung; Manoj Pandey; Kwang Seok Ahn; Tingfang Yi; Madan M Chaturvedi; Mingyao Liu; Bharat B Aggarwal
Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-kappaB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the inhibitory subunit of nuclear factor-kappaBalpha kinase, leading to potentiation of apoptosis.
Blood 2008;111(10):4880-91.
2008: Yasunari Takada; Gautam Sethi; Bokyung Sung; Bharat B Aggarwal
Flavopiridol suppresses tumor necrosis factor-induced activation of activator protein-1, c-Jun N-terminal kinase, p38 mitogen-activated protein kinase (MAPK), p44/p42 MAPK, and Akt, inhibits expression of antiapoptotic gene products, and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells.
Molecular pharmacology 2008;73(5):1549-57.
2008: Gautam Sethi; Bokyung Sung; Bharat B Aggarwal
TNF: a master switch for inflammation to cancer.
Frontiers in bioscience : a journal and virtual library 2008;13():5094-107.
2008: Bokyung Sung; Manoj Pandey; Yuki Nakajima; Hiroshi Nishida; Tetsuya Konishi; Madan M Chaturvedi; Bharat B Aggarwal
Identification of a novel blocker of IkappaBalpha kinase activation that enhances apoptosis and inhibits proliferation and invasion by suppressing nuclear factor-kappaB.
Molecular cancer therapeutics 2008;7(1):191-201.
2007: Manoj Pandey; Bokyung Sung; Kwang Seok Ahn; Ajaikumar Kunnumakkara; Madan M Chaturvedi; Bharat B Aggarwal
Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-kappaB signaling pathway.
Blood 2007;110(10):3517-25.
2007: Yasunari Takada; Bokyung Sung; Gautam Sethi; Madan M Chaturvedi; Bharat B Aggarwal
Evidence that genetic deletion of the TNF receptor p60 or p80 inhibits Fas mediated apoptosis in macrophages.
Biochemical pharmacology 2007;74(7):1057-64.
2007: Santosh K Sandur; Haruyo Ichikawa; Manoj Pandey; Ajaikumar Kunnumakkara; Bokyung Sung; Gautam Sethi; Bharat B Aggarwal
Role of pro-oxidants and antioxidants in the anti-inflammatory and apoptotic effects of curcumin (diferuloylmethane).
Free radical biology & medicine 2007;43(4):568-80.
2007: Santosh K Sandur; Manoj Pandey; Bokyung Sung; Kwang Seok Ahn; Akira Murakami; Gautam Sethi; Pornngarm Limtrakul; Vladimir Badmaev; Bharat B Aggarwal
Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism.
Carcinogenesis 2007;28(8):1765-73.
2007: Manoj Pandey; Santosh K Sandur; Bokyung Sung; Gautam Sethi; Ajaikumar Kunnumakkara; Bharat B Aggarwal
Butein, a tetrahydroxychalcone, inhibits nuclear factor (NF)-kappaB and NF-kappaB-regulated gene expression through direct inhibition of IkappaBalpha kinase beta on cysteine 179 residue.
The Journal of biological chemistry 2007;282(24):17340-50.
2007: Dinesh Khanna; Gautam Sethi; Kwang Seok Ahn; Manoj Pandey; Ajaikumar Kunnumakkara; Bokyung Sung; Amita Aggarwal; Bharat B Aggarwal
Natural products as a gold mine for arthritis treatment.
Current opinion in pharmacology 2007;7(3):344-51.
2007: Bokyung Sung; Manoj Pandey; Bharat B Aggarwal
Fisetin, an inhibitor of cyclin-dependent kinase 6, down-regulates nuclear factor-kappaB-regulated cell proliferation, antiapoptotic and metastatic gene products through the suppression of TAK-1 and receptor-interacting protein-regulated IkappaBalpha kinase activation.
Molecular pharmacology 2007;71(6):1703-14.
2007: Bharat B Aggarwal; Sanjeev Banerjee; Uddalak Bharadwaj; Bokyung Sung; Shishir Shishodia; Gautam Sethi
Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines.
Biochemical pharmacology 2007;73(7):1024-32.
2006: Bharat B Aggarwal; Gautam Sethi; Kwang Seok Ahn; Santosh K Sandur; Manoj Pandey; Ajaikumar Kunnumakkara; Bokyung Sung; Haruyo Ichikawa
Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solution.
Annals of the New York Academy of Sciences 2006;1091():151-69.
2006: Kwang Seok Ahn; Gautam Sethi; Shishir Shishodia; Bokyung Sung; Jack L Arbiser; Bharat B Aggarwal
Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-kappaB activation pathway.
Molecular cancer research : MCR 2006;4(9):621-33.