Patrick Sung

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Colavito Sierra; Macris-Kiss Margaret; Seong Changhyun; Gleeson Olive; Greene Eric C; Klein Hannah L; Krejci Lumir; Sung Patrick
Functional significance of the Rad51-Srs2 complex in Rad51 presynaptic filament disruption.
Seong Changhyun; Colavito Sierra; Kwon Youngho; Sung Patrick; Krejci Lumir
Regulation of Rad51 recombinase presynaptic filament assembly via interactions with the Rad52 mediator and the Srs2 anti-recombinase.
Robertson Ragan B; Moses Dana N; Kwon YoungHo; Chan Pamela; Chi Peter; Klein Hannah; Sung Patrick; Greene Eric C
Structural transitions within human Rad51 nucleoprotein filaments.

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All Publications

2009: Colavito Sierra; Macris-Kiss Margaret; Seong Changhyun; Gleeson Olive; Greene Eric C; Klein Hannah L; Krejci Lumir; Sung Patrick
Functional significance of the Rad51-Srs2 complex in Rad51 presynaptic filament disruption.
Nucleic acids research 2009;37(20):6754-64.
2009: Seong Changhyun; Colavito Sierra; Kwon Youngho; Sung Patrick; Krejci Lumir
Regulation of Rad51 recombinase presynaptic filament assembly via interactions with the Rad52 mediator and the Srs2 anti-recombinase.
The Journal of biological chemistry 2009;284(36):24363-71.
2009: Robertson Ragan B; Moses Dana N; Kwon YoungHo; Chan Pamela; Chi Peter; Klein Hannah; Sung Patrick; Greene Eric C
Structural transitions within human Rad51 nucleoprotein filaments.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(31):12688-93.
2009: Longerich Simonne; San Filippo Joseph; Liu Dongqing; Sung Patrick
FANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCL.
The Journal of biological chemistry 2009;284(35):23182-6.
2009: Niu Hengyao; Raynard Steven; Sung Patrick
Multiplicity of DNA end resection machineries in chromosome break repair.
Genes & development 2009;23(13):1481-6.
2009: Burgess Rebecca C; Lisby Michael; Altmannova Veronika; Krejci Lumir; Sung Patrick; Rothstein Rodney
Localization of recombination proteins and Srs2 reveals anti-recombinase function in vivo.
The Journal of cell biology 2009;185(6):969-81.
2009: Robertson Ragan B; Moses Dana N; Kwon YoungHo; Chan Pamela; Zhao Weixing; Chi Peter; Klein Hannah; Sung Patrick; Greene Eric C
Visualizing the disassembly of S. cerevisiae Rad51 nucleoprotein filaments.
Journal of molecular biology 2009;388(4):703-20.
2009: Matulova Petra; Marini Victoria; Burgess Rebecca C; Sisakova Alexandra; Kwon Youngho; Rothstein Rodney; Sung Patrick; Krejci Lumir
Cooperativity of Mus81.Mms4 with Rad54 in the resolution of recombination and replication intermediates.
The Journal of biological chemistry 2009;284(12):7733-45.
2009: Chi Peter; Kwon Youngho; Moses Dana N; Seong Changhyun; Sehorn Michael G; Singh Akhilesh K; Tsubouchi Hideo; Greene Eric C; Klein Hannah L; Sung Patrick
Functional interactions of meiotic recombination factors Rdh54 and Dmc1.
DNA repair 2009;8(2):279-84.
2009: Prakash Rohit; Satory Dominik; Dray Eloïse; Papusha Almas; Scheller Jürgen; Kramer Wilfried; Krejci Lumir; Klein Hannah; Haber James E; Sung Patrick; Ira Grzegorz
Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination.
Genes & development 2009;23(1):67-79.
2008: Raynard Steven; Niu Hengyao; Sung Patrick
DNA double-strand break processing: the beginning of the end.
Genes & development 2008;22(21):2903-7.
2008: Singh Thiyam Ramsing; Ali Abdullah Mahmood; Busygina Valeria; Raynard Steven; Fan Qiang; Du Chang-hu; Andreassen Paul R; Sung Patrick; Meetei Amom Ruhikanta
BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome.
Genes & development 2008;22(20):2856-68.
2008: Plate Iben; Hallwyl Swee C L; Shi Idina; Krejci Lumir; Müller Christian; Albertsen Line; Sung Patrick; Mortensen Uffe H
Interaction with RPA is necessary for Rad52 repair center formation and for its mediator activity.
The Journal of biological chemistry 2008;283(43):29077-85.
2008: Raynard Steven; Zhao Weixing; Bussen Wendy; Lu Lucy; Ding Yang-Yang; Busygina Valeria; Meetei Amom Ruhikanta; Sung Patrick
Functional role of BLAP75 in BLM-topoisomerase IIIalpha-dependent holliday junction processing.
The Journal of biological chemistry 2008;283(23):15701-8.
2008: Seong Changhyun; Sehorn Michael G; Plate Iben; Shi Idina; Song Binwei; Chi Peter; Mortensen Uffe; Sung Patrick; Krejci Lumir
Molecular anatomy of the recombination mediator function of Saccharomyces cerevisiae Rad52.
The Journal of biological chemistry 2008;283(18):12166-74.
2008: Kwon YoungHo; Seong Changhyun; Chi Peter; Greene Eric C; Klein Hannah; Sung Patrick
ATP-dependent chromatin remodeling by the Saccharomyces cerevisiae homologous recombination factor Rdh54.
The Journal of biological chemistry 2008;283(16):10445-52.
2008: Busygina Valeria; Sehorn Michael G; Shi Idina Y; Tsubouchi Hideo; Roeder G Shirleen; Sung Patrick
Hed1 regulates Rad51-mediated recombination via a novel mechanism.
Genes & development 2008;22(6):786-95.
2008: Sung Patrick
Structural insights into DNA lesion bypass.
Structure (London, England : 1993) 2008;16(2):161-2.
2008: Plate Iben; Albertsen Line; Lisby Michael; Hallwyl Swee C L; Feng Qi; Seong Changhyun; Rothstein Rodney; Sung Patrick; Mortensen Uffe H
Rad52 multimerization is important for its nuclear localization in Saccharomyces cerevisiae.
DNA repair 2008;7(1):57-66.
2008: San Filippo Joseph; Sung Patrick; Klein Hannah
Mechanism of eukaryotic homologous recombination.
Annual review of biochemistry 2008;77():229-57.
2007: Hu Yiduo; Raynard Steven; Sehorn Michael G; Lu Xincheng; Bussen Wendy; Zheng Lu; Stark Jeremy M; Barnes Ellen L; Chi Peter; Janscak Pavel; Jasin Maria; Vogel Hannes; Sung Patrick; Luo Guangbin
RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments.
Genes & development 2007;21(23):3073-84.
2007: Wiese Claudia; Dray Eloïse; Groesser Torsten; San Filippo Joseph; Shi Idina; Collins David W; Tsai Miaw-Sheue; Williams Gareth J; Rydberg Bjorn; Sung Patrick; Schild David
Promotion of homologous recombination and genomic stability by RAD51AP1 via RAD51 recombinase enhancement.
Molecular cell 2007;28(3):482-90.
2007: Xie Yang; Kerscher Oliver; Kroetz Mary B; McConchie Heather F; Sung Patrick; Hochstrasser Mark
The yeast Hex3.Slx8 heterodimer is a ubiquitin ligase stimulated by substrate sumoylation.
The Journal of biological chemistry 2007;282(47):34176-84.
2007: Bussen Wendy; Raynard Steven; Busygina Valeria; Singh Akhilesh K; Sung Patrick
Holliday junction processing activity of the BLM-Topo IIIalpha-BLAP75 complex.
The Journal of biological chemistry 2007;282(43):31484-92.
2007: Kwon Youngho; Chi Peter; Roh Dong Hyun; Klein Hannah; Sung Patrick
Synergistic action of the Saccharomyces cerevisiae homologous recombination factors Rad54 and Rad51 in chromatin remodeling.
DNA repair 2007;6(10):1496-506.
2007: Chi Peter; San Filippo Joseph; Sehorn Michael G; Petukhova Galina V; Sung Patrick
Bipartite stimulatory action of the Hop2-Mnd1 complex on the Rad51 recombinase.
Genes & development 2007;21(14):1747-57.
2007: Zhang Yu; Hefferin Melissa L; Chen Ling; Shim Eun Yong; Tseng Hui-Min; Kwon Youngho; Sung Patrick; Lee Sang Eun; Tomkinson Alan E
Role of Dnl4-Lif1 in nonhomologous end-joining repair complex assembly and suppression of homologous recombination.
Nature structural & molecular biology 2007;14(7):639-46.
2007: Prasad Tekkatte Krishnamurthy; Robertson Ragan B; Visnapuu Mari-Liis; Chi Peter; Sung Patrick; Greene Eric C
A DNA-translocating Snf2 molecular motor: Saccharomyces cerevisiae Rdh54 displays processive translocation and extrudes DNA loops.
Journal of molecular biology 2007;369(4):940-53.
2006: Sung Patrick; Klein Hannah
Mechanism of homologous recombination: mediators and helicases take on regulatory functions.
Nature reviews. Molecular cell biology 2006;7(10):739-50.
2006: Chi Peter; Kwon Youngho; Seong Changhyun; Epshtein Anastasiya; Lam Isabel; Sung Patrick; Klein Hannah L
Yeast recombination factor Rdh54 functionally interacts with the Rad51 recombinase and catalyzes Rad51 removal from DNA.
The Journal of biological chemistry 2006;281(36):26268-79.
2006: Raynard Steven; Bussen Wendy; Sung Patrick
A double Holliday junction dissolvasome comprising BLM, topoisomerase IIIalpha, and BLAP75.
The Journal of biological chemistry 2006;281(20):13861-4.
2006: San Filippo Joseph; Chi Peter; Sehorn Michael G; Etchin Julia; Krejci Lumir; Sung Patrick
Recombination mediator and Rad51 targeting activities of a human BRCA2 polypeptide.
The Journal of biological chemistry 2006;281(17):11649-57.
2006: Chi Peter; Van Komen Stephen; Sehorn Michael G; Sigurdsson Stefan; Sung Patrick
Roles of ATP binding and ATP hydrolysis in human Rad51 recombinase function.
DNA repair 2006;5(3):381-91.
2006: Wesoly Joanna; Agarwal Sheba; Sigurdsson Stefan; Bussen Wendy; Van Komen Stephen; Qin Jian; van Steeg Harry; van Benthem Jan; Wassenaar Evelyne; Baarends Willy M; Ghazvini Mehrnaz; Tafel Agnieszka A; Heath Helen; Galjart Niels; Essers Jeroen; Grootegoed J Anton; Arnheim Norman; Bezzubova Olga; Buerstedde Jean-Marie; Sung Patrick; Kanaar Roland
Differential contributions of mammalian Rad54 paralogs to recombination, DNA damage repair, and meiosis.
Molecular and cellular biology 2006;26(3):976-89.
2006: Macris Margaret A; Krejci Lumir; Bussen Wendy; Shimamoto Akira; Sung Patrick
Biochemical characterization of the RECQ4 protein, mutated in Rothmund-Thomson syndrome.
DNA repair 2006;5(2):172-80.
2006: Desfarges S; San Filippo J; Fournier M; Calmels C; Caumont-Sarcos A; Litvak S; Sung P; Parissi V
Chromosomal integration of LTR-flanked DNA in yeast expressing HIV-1 integrase: down regulation by RAD51.
Nucleic acids research 2006;34(21):6215-24.
2006: Van Komen Stephen; Macris Margaret; Sehorn Michael G; Sung Patrick
Purification and assays of Saccharomyces cerevisiae homologous recombination proteins.
Methods in enzymology 2006;408():445-63.
2005: Macris M A; Sung P
Multifaceted role of the Saccharomyces cerevisiae Srs2 helicase in homologous recombination regulation.
Biochemical Society transactions 2005;33(Pt 6):1447-50.
2005: Papouli Efterpi; Chen Shuhua; Davies Adelina A; Huttner Diana; Krejci Lumir; Sung Patrick; Ulrich Helle D
Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2p.
Molecular cell 2005;19(1):123-33.
2005: Prakash Rohit; Krejci Lumir; Van Komen Stephen; Anke Schürer Kirsten; Kramer Wilfried; Sung Patrick
Saccharomyces cerevisiae MPH1 gene, required for homologous recombination-mediated mutation avoidance, encodes a 3' to 5' DNA helicase.
The Journal of biological chemistry 2005;280(9):7854-60.
2005: Chen Ling; Trujillo Kelly M; Van Komen Stephen; Roh Dong Hyun; Krejci Lumir; Lewis L Kevin; Resnick Michael A; Sung Patrick; Tomkinson Alan E
Effect of amino acid substitutions in the rad50 ATP binding domain on DNA double strand break repair in yeast.
The Journal of biological chemistry 2005;280(4):2620-7.
2004: Raschle Markus; Van Komen Stephen; Chi Peter; Ellenberger Tom; Sung Patrick
Multiple interactions with the Rad51 recombinase govern the homologous recombination function of Rad54.
The Journal of biological chemistry 2004;279(50):51973-80.
2004: Sehorn Michael G; Sung Patrick
Meiotic recombination: an affair of two recombinases.
Cell cycle (Georgetown, Tex.) 2004;3(11):1375-7.
2004: de Jager Martijn; Trujillo Kelly M; Sung Patrick; Hopfner Karl-Peter; Carney James P; Tainer John A; Connelly John C; Leach David R F; Kanaar Roland; Wyman Claire
Differential arrangements of conserved building blocks among homologs of the Rad50/Mre11 DNA repair protein complex.
Journal of molecular biology 2004;339(4):937-49.
2004: Smirnova Marina; Van Komen Stephen; Sung Patrick; Klein Hannah L
Effects of tumor-associated mutations on Rad54 functions.
The Journal of biological chemistry 2004;279(23):24081-8.
2004: Sehorn Michael G; Sigurdsson Stefan; Bussen Wendy; Unger Vinzenz M; Sung Patrick
Human meiotic recombinase Dmc1 promotes ATP-dependent homologous DNA strand exchange.
Nature 2004;429(6990):433-7.
2004: Krejci Lumir; Macris Margaret; Li Ying; Van Komen Stephen; Villemain Jana; Ellenberger Thomas; Klein Hannah; Sung Patrick
Role of ATP hydrolysis in the antirecombinase function of Saccharomyces cerevisiae Srs2 protein.
The Journal of biological chemistry 2004;279(22):23193-9.
2004: Lewis L Kevin; Storici Francesca; Van Komen Stephen; Calero Shanna; Sung Patrick; Resnick Michael A
Role of the nuclease activity of Saccharomyces cerevisiae Mre11 in repair of DNA double-strand breaks in mitotic cells.
Genetics 2004;166(4):1701-13.
2004: Motycka Teresa A; Bessho Tadayoshi; Post Sean M; Sung Patrick; Tomkinson Alan E
Physical and functional interaction between the XPF/ERCC1 endonuclease and hRad52.
The Journal of biological chemistry 2004;279(14):13634-9.
2003: Trujillo Kelly M; Roh Dong Hyun; Chen Ling; Van Komen Stephen; Tomkinson Alan; Sung Patrick
Yeast xrs2 binds DNA and helps target rad50 and mre11 to DNA ends.
The Journal of biological chemistry 2003;278(49):48957-64.
2003: Van Komen Stephen; Reddy Mothe Sreedhar; Krejci Lumir; Klein Hannah; Sung Patrick
ATPase and DNA helicase activities of the Saccharomyces cerevisiae anti-recombinase Srs2.
The Journal of biological chemistry 2003;278(45):44331-7.
2003: Sung Patrick; Krejci Lumir; Van Komen Stephen; Sehorn Michael G
Rad51 recombinase and recombination mediators.
The Journal of biological chemistry 2003;278(44):42729-32.
2003: Mallory Julia C; Bashkirov Vladimir I; Trujillo Kelly M; Solinger Jachen A; Dominska Margaret; Sung Patrick; Heyer Wolf Dietrich; Petes Thomas D
Amino acid changes in Xrs2p, Dun1p, and Rfa2p that remove the preferred targets of the ATM family of protein kinases do not affect DNA repair or telomere length in Saccharomyces cerevisiae.
DNA repair 2003;2(9):1041-64.
2003: Wolner Branden; van Komen Stephen; Sung Patrick; Peterson Craig L
Recruitment of the recombinational repair machinery to a DNA double-strand break in yeast.
Molecular cell 2003;12(1):221-32.
2003: Krejci Lumir; Van Komen Stephen; Li Ying; Villemain Jana; Reddy Mothe Sreedhar; Klein Hannah; Ellenberger Thomas; Sung Patrick
DNA helicase Srs2 disrupts the Rad51 presynaptic filament.
Nature 2003;423(6937):305-9.
2003: Jaskelioff Mariela; Van Komen Stephen; Krebs Jocelyn E; Sung Patrick; Peterson Craig L
Rad54p is a chromatin remodeling enzyme required for heteroduplex DNA joint formation with chromatin.
The Journal of biological chemistry 2003;278(11):9212-8.
2003: Krejci Lumir; Chen Ling; Van Komen Stephen; Sung Patrick; Tomkinson Alan
Mending the break: two DNA double-strand break repair machines in eukaryotes.
Progress in nucleic acid research and molecular biology 2003;74():159-201.
2002: Van Komen Stephen; Petukhova Galina; Sigurdsson Stefan; Sung Patrick
Functional cross-talk among Rad51, Rad54, and replication protein A in heteroduplex DNA joint formation.
The Journal of biological chemistry 2002;277(46):43578-87.
2002: Sigurdsson Stefan; Van Komen Stephen; Petukhova Galina; Sung Patrick
Homologous DNA pairing by human recombination factors Rad51 and Rad54.
The Journal of biological chemistry 2002;277(45):42790-4.
2002: Krejci Lumir; Song Binwei; Bussen Wendy; Rothstein Rodney; Mortensen Uffe H; Sung Patrick
Interaction with Rad51 is indispensable for recombination mediator function of Rad52.
The Journal of biological chemistry 2002;277(42):40132-41.
2002: Krejci Lumir; Sung Patrick
Of forks and ends.
Trends in biochemical sciences 2002;27(5):225-6.
2002: Krejci Lumir; Sung Patrick
RPA not that different from SSB.
Structure (London, England : 1993) 2002;10(5):601-2.
2001: Sigurdsson S; Van Komen S; Bussen W; Schild D; Albala J S; Sung P
Mediator function of the human Rad51B-Rad51C complex in Rad51/RPA-catalyzed DNA strand exchange.
Genes & development 2001;15(24):3308-18.
2001: Chen L; Trujillo K; Ramos W; Sung P; Tomkinson A E
Promotion of Dnl4-catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 complexes.
Molecular cell 2001;8(5):1105-15.
2001: Anderson D E; Trujillo K M; Sung P; Erickson H P
Structure of the Rad50 x Mre11 DNA repair complex from Saccharomyces cerevisiae by electron microscopy.
The Journal of biological chemistry 2001;276(40):37027-33.
2001: Trujillo K M; Sung P
DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50*Mre11 complex.
The Journal of biological chemistry 2001;276(38):35458-64.
2001: Sigurdsson S; Trujillo K; Song B; Stratton S; Sung P
Basis for avid homologous DNA strand exchange by human Rad51 and RPA.
The Journal of biological chemistry 2001;276(12):8798-806.
2000: Van Komen S; Petukhova G; Sigurdsson S; Stratton S; Sung P
Superhelicity-driven homologous DNA pairing by yeast recombination factors Rad51 and Rad54.
Molecular cell 2000;6(3):563-72.
2000: Petukhova G; Sung P; Klein H
Promotion of Rad51-dependent D-loop formation by yeast recombination factor Rdh54/Tid1.
Genes & development 2000;14(17):2206-15.
2000: Chen L; Trujillo K; Sung P; Tomkinson A E
Interactions of the DNA ligase IV-XRCC4 complex with DNA ends and the DNA-dependent protein kinase.
The Journal of biological chemistry 2000;275(34):26196-205.
2000: Sung P; Trujillo K M; Van Komen S
Recombination factors of Saccharomyces cerevisiae.
Mutation research 2000;451(1-2):257-75.
2000: Song B; Sung P
Functional interactions among yeast Rad51 recombinase, Rad52 mediator, and replication protein A in DNA strand exchange.
The Journal of biological chemistry 2000;275(21):15895-904.
1999: Dasika G K; Lin S C; Zhao S; Sung P; Tomkinson A; Lee E Y
DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis.
Oncogene 1999;18(55):7883-99.
1999: Petukhova G; Stratton S A; Sung P
Single strand DNA binding and annealing activities in the yeast recombination factor Rad59.
The Journal of biological chemistry 1999;274(48):33839-42.
1999: Petukhova G; Van Komen S; Vergano S; Klein H; Sung P
Yeast Rad54 promotes Rad51-dependent homologous DNA pairing via ATP hydrolysis-driven change in DNA double helix conformation.
The Journal of biological chemistry 1999;274(41):29453-62.
1999: Chen G; Yuan S S; Liu W; Xu Y; Trujillo K; Song B; Cong F; Goff S P; Wu Y; Arlinghaus R; Baltimore D; Gasser P J; Park M S; Sung P; Lee E Y
Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl.
The Journal of biological chemistry 1999;274(18):12748-52.
1998: Trujillo K M; Yuan S S; Lee E Y; Sung P
Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95.
The Journal of biological chemistry 1998;273(34):21447-50.
1998: Petukhova G; Stratton S; Sung P
Catalysis of homologous DNA pairing by yeast Rad51 and Rad54 proteins.
Nature 1998;393(6680):91-4.
1997: Sung P
Function of yeast Rad52 protein as a mediator between replication protein A and the Rad51 recombinase.
The Journal of biological chemistry 1997;272(45):28194-7.

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