Claudiu Supuran

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Concepts & Ideas

Sign-in to see full Profile

Sign-in to see all Coauthors

Publications

TOP 3
Steele Rebecca M; Benedini Francesca; Biondi Stefano; Borghi Valentina; Carzaniga Laura; Impagnatiello Francesco; Miglietta Daniela; Chong Wesley K M; Rajapakse Ranjan; Cecchi Alessandro; Temperini Claudia; Supuran Claudiu T
Nitric oxide-donating carbonic anhydrase inhibitors for the treatment of open-angle glaucoma.
Carta Fabrizio; Maresca Alfonso; Covarrubias Adrian Suarez; Mowbray Sherry L; Jones T Alwyn; Supuran Claudiu T
Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c.
Winum Jean-Yves; Montero Jean-Louis; Vullo Daniela; Supuran Claudiu T
Carbonic anhydrase inhibitors: glycosylsulfanilamides act as subnanomolar inhibitors of the human secreted isoform VI.

Sign-in to see all Publications

Sign in free and see...

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the visualized research activity
of experts around the globe

Sign-in to see more

Geonetwork of Claudiu Supuran (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

Sign-in to see more

All Publications

2009: Steele Rebecca M; Benedini Francesca; Biondi Stefano; Borghi Valentina; Carzaniga Laura; Impagnatiello Francesco; Miglietta Daniela; Chong Wesley K M; Rajapakse Ranjan; Cecchi Alessandro; Temperini Claudia; Supuran Claudiu T
Nitric oxide-donating carbonic anhydrase inhibitors for the treatment of open-angle glaucoma.
Bioorganic & medicinal chemistry letters 2009;19(23):6565-70.
2009: Carta Fabrizio; Maresca Alfonso; Covarrubias Adrian Suarez; Mowbray Sherry L; Jones T Alwyn; Supuran Claudiu T
Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c.
Bioorganic & medicinal chemistry letters 2009;19(23):6649-54.
2009: Winum Jean-Yves; Montero Jean-Louis; Vullo Daniela; Supuran Claudiu T
Carbonic anhydrase inhibitors: glycosylsulfanilamides act as subnanomolar inhibitors of the human secreted isoform VI.
Chemical biology & drug design 2009;74(6):636-9.
2009: Hulikova Alzbeta; Zatovicova Miriam; Svastova Eliska; Ditte Peter; Brasseur Robert; Kettmann Richard; Supuran Claudiu T; Kopacek Juraj; Pastorek Jaromir; Pastorekova Silvia
Intact intracellular tail is critical for proper functioning of the tumor-associated, hypoxia-regulated carbonic anhydrase IX.
FEBS letters 2009;583(22):3563-8.
2009: Nasr Gihane; Petit Eddy; Supuran Claudiu T; Winum Jean-Yves; Barboiu Mihail
Carbonic anhydrase II-induced selection of inhibitors from a dynamic combinatorial library of Schiff's bases.
Bioorganic & medicinal chemistry letters 2009;19(21):6014-7.
2009: Lopez Marie; Paul Blessy; Hofmann Andreas; Morizzi Julia; Wu Quoc K; Charman Susan A; Innocenti Alessio; Vullo Daniela; Supuran Claudiu T; Poulsen Sally-Ann
S-glycosyl primary sulfonamides--a new structural class for selective inhibition of cancer-associated carbonic anhydrases.
Journal of medicinal chemistry 2009;52(20):6421-32.
2009: Ciani Laura; Cecchi Alessandro; Temperini Claudia; Supuran Claudiu T; Ristori Sandra
Dissecting the inhibition mechanism of cytosolic versus transmembrane carbonic anhydrases by ESR.
The journal of physical chemistry. B 2009;113(42):13998-4005.
2009: Carta Fabrizio; Maresca Alfonso; Scozzafava Andrea; Vullo Daniela; Supuran Claudiu T
Carbonic anhydrase inhibitors. Diazenylbenzenesulfonamides are potent and selective inhibitors of the tumor-associated isozymes IX and XII over the cytosolic isoforms I and II.
Bioorganic & medicinal chemistry 2009;17(20):7093-9.
2009: Innocenti Alessio; Pastorekova Silvia; Pastorek Jaromir; Scozzafava Andrea; De Simone Giuseppina; Supuran Claudiu T
The proteoglycan region of the tumor-associated carbonic anhydrase isoform IX acts as anintrinsic buffer optimizing CO2 hydration at acidic pH values characteristic of solid tumors.
Bioorganic & medicinal chemistry letters 2009;19(20):5825-8.
2009: Vitale Rosa Maria; Alterio Vincenzo; Innocenti Alessio; Winum Jean-Yves; Monti Simona Maria; De Simone Giuseppina; Supuran Claudiu T
Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors.
Journal of medicinal chemistry 2009;52(19):5990-8.
2009: Alterio Vincenzo; Hilvo Mika; Di Fiore Anna; Supuran Claudiu T; Pan Peiwen; Parkkila Seppo; Scaloni Andrea; Pastorek Jaromir; Pastorekova Silvia; Pedone Carlo; Scozzafava Andrea; Monti Simona Maria; De Simone Giuseppina
Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(38):16233-8.
2009: De Simone Giuseppina; Scozzafava Andrea; Supuran Claudiu T
Which carbonic anhydrases are targeted by the antiepileptic sulfonamides and sulfamates?
Chemical biology & drug design 2009;74(3):317-21.
2009: Maresca Alfonso; Carta Fabrizio; Vullo Daniela; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of the Rv1284 and Rv3273 beta-carbonic anhydrases from Mycobacterium tuberculosis with diazenylbenzenesulfonamides.
Bioorganic & medicinal chemistry letters 2009;19(17):4929-32.
2009: Winum Jean-Yves; Innocenti Alessio; Vullo Daniela; Montero Jean-Louis; Supuran Claudiu T
Carbonic anhydrase inhibitors; fluorinated phenyl sulfamates show strong inhibitory activity and selectivity for the inhibition of the tumor-associated isozymes IX and XII over the cytosolic ones I and II.
Bioorganic & medicinal chemistry letters 2009;19(17):5082-5.
2009: Dubois Ludwig; Lieuwes Natasja G; Maresca Alfonso; Thiry Anne; Supuran Claudiu T; Scozzafava Andrea; Wouters Bradly G; Lambin Philippe
Imaging of CA IX with fluorescent labelled sulfonamides distinguishes hypoxic and (re)-oxygenated cells in a xenograft tumour model.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2009;92(3):423-8.
2009: Abdülkadir Coban T; Beydemir Sükrü; Gücin Ilhami; Ekinci Deniz; Innocenti Alessio; Vullo Daniela; Supuran Claudiu T
Sildenafil is a strong activator of mammalian carbonic anhydrase isoforms I-XIV.
Bioorganic & medicinal chemistry 2009;17(16):5791-5.
2009: Nasr Gihane; Petit Eddy; Vullo Daniela; Winum Jean-Yves; Supuran Claudiu T; Barboiu Mihail
Carbonic anhydrase-encoded dynamic constitutional libraries: toward the discovery of isozyme-specific inhibitors.
Journal of medicinal chemistry 2009;52(15):4853-9.
2009: Innocenti Alessio; Leewattanapasuk Worraanong; Mühlschlegel Fritz A; Mastrolorenzo Antonio; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the pathogenic yeast Candida glabrata with anions.
Bioorganic & medicinal chemistry letters 2009;19(16):4802-5.
2009: Carta Fabrizio; Pothen Blessy; Maresca Alfonso; Tiwari Meena; Singh Vineet; Supuran Claudiu T
Carbonic anhydrase inhibitors: inhibition of cytosolic carbonic anhydrase isozymes II and VII with simple aromatic sulfonamides and some azo dyes.
Chemical biology & drug design 2009;74(2):196-202.
2009: Parkkila Seppo; Innocenti Alessio; Kallio Heini; Hilvo Mika; Scozzafava Andrea; Supuran Claudiu T
The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian alpha-carbonic anhydrase isoforms.
Bioorganic & medicinal chemistry letters 2009;19(15):4102-6.
2009: Loughrey Bradley T; Williams Michael L; Healy Peter C; Innocenti Alessio; Vullo Daniela; Supuran Claudiu T; Parsons Peter G; Poulsen Sally-Ann
Novel organometallic cationic ruthenium(II) pentamethylcyclopentadienyl benzenesulfonamide complexes targeted to inhibit carbonic anhydrase.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2009;14(6):935-45.
2009: Winum Jean-Yves; Scozzafava Andrea; Montero Jean-Louis; Supuran Claudiu T
Inhibition of carbonic anhydrase IX: a new strategy against cancer.
Anti-cancer agents in medicinal chemistry 2009;9(6):693-702.
2009: Güzel Ozlen; Innocenti Alessio; Scozzafava Andrea; Salman Aydin; Supuran Claudiu T
Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB.
Bioorganic & medicinal chemistry 2009;17(14):4894-9.
2009: Bertucci Anthony; Innocenti Alessio; Zoccola Didier; Scozzafava Andrea; Tambutté Sylvie; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides.
Bioorganic & medicinal chemistry 2009;17(14):5054-8.
2009: Innocenti Alessio; Hilvo Mika; Parkkila Seppo; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase activators. Activation of the membrane-associated isoform XV with amino acids and amines.
Bioorganic & medicinal chemistry letters 2009;19(13):3430-3.
2009: Swietach Pawel; Patiar Shalini; Supuran Claudiu T; Harris Adrian L; Vaughan-Jones Richard D
The role of carbonic anhydrase 9 in regulating extracellular and intracellular ph in three-dimensional tumor cell growths.
The Journal of biological chemistry 2009;284(30):20299-310.
2009: Innocenti Alessio; Hall Rebecca A; Schlicker Christine; Scozzafava Andrea; Steegborn Clemens; Mühlschlegel Fritz A; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.
Bioorganic & medicinal chemistry 2009;17(13):4503-9.
2009: Güzel Ozlen; Maresca Alfonso; Scozzafava Andrea; Salman Aydin; Balaban Alexandru T; Supuran Claudiu T
Discovery of low nanomolar and subnanomolar inhibitors of the mycobacterial beta-carbonic anhydrases Rv1284 and Rv3273.
Journal of medicinal chemistry 2009;52(13):4063-7.
2009: Güzel Ozlen; Innocenti Alessio; Scozzafava Andrea; Salman Aydin; Supuran Claudiu T
Carbonic anhydrase inhibitors. Phenacetyl-, pyridylacetyl- and thienylacetyl-substituted aromatic sulfonamides act as potent and selective isoform VII inhibitors.
Bioorganic & medicinal chemistry letters 2009;19(12):3170-3.
2009: Almstedt Karin; Rafstedt Therese; Supuran Claudiu T; Carlsson Uno; Hammarström Per
Small-molecule suppression of misfolding of mutated human carbonic anhydrase II linked to marble brain disease.
Biochemistry 2009;48(23):5358-64.
2009: Güzel Ozlen; Maresca Alfonso; Scozzafava Andrea; Salman Aydin; Balaban Alexandru T; Supuran Claudiu T
Carbonic anhydrase inhibitors. Synthesis of 2,4,6-trimethylpyridinium derivatives of 2-(hydrazinocarbonyl)-3-aryl-1H-indole-5-sulfonamides acting as potent inhibitors of the tumor-associated isoform IX and XII.
Bioorganic & medicinal chemistry letters 2009;19(11):2931-4.
2009: Gitto Rosaria; Ferro Stefania; Agnello Stefano; De Luca Laura; De Sarro Giovanbattista; Russo Emilio; Vullo Daniela; Supuran Claudiu T; Chimirri Alba
Synthesis and evaluation of pharmacological profile of 1-aryl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamides.
Bioorganic & medicinal chemistry 2009;17(10):3659-64.
2009: Winum Jean-Yves; Innocenti Alessio; Scozzafava Andrea; Montero Jean-Louis; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isoforms I and II and transmembrane, tumor-associated isoforms IX and XII with boronic acids.
Bioorganic & medicinal chemistry 2009;17(10):3649-52.
2009: Innocenti Alessio; Winum Jean-Yves; Hall Rebecca A; Mühlschlegel Fritz A; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids.
Bioorganic & medicinal chemistry letters 2009;19(10):2642-5.
2009: Durdagi Serdar; Supuran Claudiu T; Strom T Amanda; Doostdar Nadjmeh; Kumar Mananjali K; Barron Andrew R; Mavromoustakos Thomas; Papadopoulos Manthos G
In silico drug screening approach for the design of magic bullets: a successful example with anti-HIV fullerene derivatized amino acids.
Journal of chemical information and modeling 2009;49(5):1139-43.
2009: Abdo Marie-Rose; Vullo Daniela; Saada Mohamed-Chiheb; Montero Jean-Louis; Scozzafava Andrea; Winum Jean-Yves; Supuran Claudiu T
Carbonic anhydrase activators: activation of human isozymes I, II and IX with phenylsulfonylhydrazido l-histidine derivatives.
Bioorganic & medicinal chemistry letters 2009;19(9):2440-3.
2009: Nishimori Isao; Minakuchi Tomoko; Vullo Daniela; Scozzafava Andrea; Innocenti Alessio; Supuran Claudiu T
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.
Journal of medicinal chemistry 2009;52(9):3116-20.
2009: Winum Jean-Yves; Poulsen Sally-Ann; Supuran Claudiu T
Therapeutic applications of glycosidic carbonic anhydrase inhibitors.
Medicinal research reviews 2009;29(3):419-35.
2009: Ebbesen Peter; Pettersen Erik O; Gorr Thomas A; Jobst Gerhard; Williams Kaye; Kieninger Jochen; Wenger Roland H; Pastorekova Silvia; Dubois Ludwig; Lambin Philippe; Wouters Brad G; Van Den Beucken Twan; Supuran Claudiu T; Poellinger Lorenz; Ratcliffe Peter; Kanopka Arvydas; Görlach Agnes; Gasmann Max; Harris Adrian L; Maxwell Patrick; Scozzafava Andrea
Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies.
Journal of enzyme inhibition and medicinal chemistry 2009;24 Suppl 1():1-39.
2009: Minakuchi Tomoko; Nishimori Isao; Vullo Daniela; Scozzafava Andrea; Supuran Claudiu T
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.
Journal of medicinal chemistry 2009;52(8):2226-32.
2009: Innocenti Alessio; Hall Rebecca A; Schlicker Christine; Mühlschlegel Fritz A; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with aliphatic and aromatic carboxylates.
Bioorganic & medicinal chemistry 2009;17(7):2654-7.
2009: Singer Mathilde; Lopez Marie; Bornaghi Laurent F; Innocenti Alessio; Vullo Daniela; Supuran Claudiu T; Poulsen Sally-Ann
Inhibition of carbonic anhydrase isozymes with benzene sulfonamides incorporating thio, sulfinyl and sulfonyl glycoside moieties.
Bioorganic & medicinal chemistry letters 2009;19(8):2273-6.
2009: Innocenti Alessio; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I, II, III, VII and XIII with less investigated inorganic anions.
Bioorganic & medicinal chemistry letters 2009;19(7):1855-7.
2009: Sentürk Murat; Gülçin Ilhami; Dastan Arif; Küfrevioglu O Irfan; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols.
Bioorganic & medicinal chemistry 2009;17(8):3207-11.
2009: Güzel Ozlen; Innocenti Alessio; Hall Rebecca A; Scozzafava Andrea; Mühlschlegel Fritz A; Supuran Claudiu T
Carbonic anhydrase inhibitors. The nematode alpha-carbonic anhydrase of Caenorhabditis elegans CAH-4b is highly inhibited by 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides.
Bioorganic & medicinal chemistry 2009;17(8):3212-5.
2009: Singh Shalini; Khadikar Padmakar V; Scozzafava Andrea; Supuran Claudiu T
QSAR studies for the inhibition of the transmembrane carbonic anhydrase isozyme XIV with sulfonamides using PRECLAV software.
Journal of enzyme inhibition and medicinal chemistry 2009;24(2):337-49.
2009: Morsy Salwa M I; Badawi Abdelfattah M; Cecchi Alessandro; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Biphenylsulfonamides with inhibitory action towards the transmembrane, tumor-associated isozymes IX possess cytotoxic activity against human colon, lung and breast cancer cell lines.
Journal of enzyme inhibition and medicinal chemistry 2009;24(2):499-505.
2009: Isik Semra; Kockar Feray; Aydin Meltem; Arslan Oktay; Guler Ozen Ozensoy; Innocenti Alessio; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase activators: activation of the beta-carbonic anhydrase Nce103 from the yeast Saccharomyces cerevisiae with amines and amino acids.
Bioorganic & medicinal chemistry letters 2009;19(6):1662-5.
2009: Vomasta Daniel; Innocenti Alessio; König Burkhard; Supuran Claudiu T
Carbonic anhydrase inhibitors: two-prong versus mono-prong inhibitors of isoforms I, II, IX, and XII exemplified by photochromic cis-1,2-alpha-dithienylethene derivatives.
Bioorganic & medicinal chemistry letters 2009;19(5):1283-6.
2009: Crocetti Letizia; Maresca Alfonso; Temperini Claudia; Hall Rebecca A; Scozzafava Andrea; Mühlschlegel Fritz A; Supuran Claudiu T
A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.
Bioorganic & medicinal chemistry letters 2009;19(5):1371-5.
2009: Hilvo Mika; Salzano Anna Maria; Innocenti Alessio; Kulomaa Markku S; Scozzafava Andrea; Scaloni Andrea; Parkkila Seppo; Supuran Claudiu T
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.
Journal of medicinal chemistry 2009;52(3):646-54.
2009: Innocenti Alessio; Hilvo Mika; Parkkila Seppo; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions.
Bioorganic & medicinal chemistry letters 2009;19(4):1155-8.
2009: Isik Semra; Kockar Feray; Aydin Meltem; Arslan Oktay; Guler Ozen Ozensoy; Innocenti Alessio; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates.
Bioorganic & medicinal chemistry 2009;17(3):1158-63.
2009: Bertucci Anthony; Innocenti Alessio; Zoccola Didier; Scozzafava Andrea; Allemand Denis; Tambutté Sylvie; Supuran Claudiu T
Carbonic anhydrase inhibitors: inhibition studies of a coral secretory isoform with inorganic anions.
Bioorganic & medicinal chemistry letters 2009;19(3):650-3.
2009: Temperini Claudia; Cecchi Alessandro; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.
Bioorganic & medicinal chemistry 2009;17(3):1214-21.
2009: Nishimori Isao; Minakuchi Tomoko; Onishi Saburo; Vullo Daniela; Cecchi Alessandro; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Cloning, characterization and inhibition studies of the cytosolic isozyme III with anions.
Journal of enzyme inhibition and medicinal chemistry 2009;24(1):70-6.
2009: Thiry Anne; Delayen Aurélie; Goossens Laurence; Houssin Raymond; Ledecq Marie; Frankart Aurélie; Dogné Jean-Michel; Wouters Johan; Supuran Claudiu T; Hénichart Jean-Pierre; Masereel Bernard
Synthesis and biological evaluation of a new family of anti-benzylanilinosulfonamides as CA IX inhibitors.
European journal of medicinal chemistry 2009;44(2):511-8.
2009: Temperini Claudia; Cecchi Alessandro; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.
Journal of medicinal chemistry 2009;52(2):322-8.
2009: Schlicker Christine; Hall Rebecca A; Vullo Daniela; Middelhaufe Sabine; Gertz Melanie; Supuran Claudiu T; Mühlschlegel Fritz A; Steegborn Clemens
Structure and inhibition of the CO2-sensing carbonic anhydrase Can2 from the pathogenic fungus Cryptococcus neoformans.
Journal of molecular biology 2009;385(4):1207-20.
2009: Rusconi Stefano; Lo Cicero Mirko; Viganò Ottavia; Sirianni Francesca; Bulgheroni Elisabetta; Ferramosca Stefania; Bencini Andrea; Bianchi Antonio; Ruiz Lidia; Cabrera Cecilia; Martinez-Picado Javier; Supuran Claudiu T; Galli Massimo
New macrocyclic amines showing activity as HIV entry inhibitors against wild type and multi-drug resistant viruses.
Molecules (Basel, Switzerland) 2009;14(5):1927-37.
2008: Isik Semra; Kockar Feray; Arslan Oktay; Guler Ozen Ozensoy; Innocenti Alessio; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with anions.
Bioorganic & medicinal chemistry letters 2008;18(24):6327-31.
2008: Smaine Fatma-Zohra; Pacchiano Fabio; Rami Marouan; Barragan-Montero Véronique; Vullo Daniela; Scozzafava Andrea; Winum Jean-Yves; Supuran Claudiu T
Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV.
Bioorganic & medicinal chemistry letters 2008;18(24):6332-5.
2008: Stiti Maamar; Cecchi Alessandro; Rami Marouan; Abdaoui Mohamed; Barragan-Montero Véronique; Scozzafava Andrea; Guari Yannick; Winum Jean-Yves; Supuran Claudiu T
Carbonic anhydrase inhibitor coated gold nanoparticles selectively inhibit the tumor-associated isoform IX over the cytosolic isozymes I and II.
Journal of the American Chemical Society 2008;130(48):16130-1.
2008: Innocenti Alessio; Zimmerman Sabrina A; Scozzafava Andrea; Ferry James G; Supuran Claudiu T
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.
Bioorganic & medicinal chemistry letters 2008;18(23):6194-8.
2008: Thiry Anne; Rolin Stéphanie; Vullo Daniela; Frankart Aurélie; Scozzafava Andrea; Dogné Jean-Michel; Wouters Johan; Supuran Claudiu T; Masereel Bernard
Indanesulfonamides as carbonic anhydrase inhibitors and anticonvulsant agents: structure-activity relationship and pharmacological evaluation.
European journal of medicinal chemistry 2008;43(12):2853-60.
2008: Rami Marouan; Cecchi Alessandro; Montero Jean-Louis; Innocenti Alessio; Vullo Daniela; Scozzafava Andrea; Winum Jean-Yves; Supuran Claudiu T
Carbonic anhydrase inhibitors: design of membrane-impermeant copper(II) complexes of DTPA-, DOTA-, and TETA-tailed sulfonamides targeting the tumor-associated transmembrane isoform IX.
ChemMedChem 2008;3(11):1780-8.
2008: Supuran C T
Antiepileptic activity of zonisamide on hippocampal CA3 neurons does not depend on carbonic anhydrase inhibition.
Epilepsy research 2008;82(1):109; author reply 110.
2008: Güzel Ozlen; Innocenti Alessio; Scozzafava Andrea; Salman Aydin; Parkkila Seppo; Hilvo Mika; Supuran Claudiu T
Carbonic anhydrase inhibitors: synthesis and inhibition studies against mammalian isoforms I-XV with a series of 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides.
Bioorganic & medicinal chemistry 2008;16(20):9113-20.
2008: Bayram Esra; Senturk Murat; Kufrevioglu O Irfan; Supuran Claudiu T
In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II.
Bioorganic & medicinal chemistry 2008;16(20):9101-5.
2008: Krungkrai Jerapan; Krungkrai Sudaratana R; Supuran Claudiu T
Carbonic anhydrase inhibitors: inhibition of Plasmodium falciparum carbonic anhydrase with aromatic/heterocyclic sulfonamides-in vitro and in vivo studies.
Bioorganic & medicinal chemistry letters 2008;18(20):5466-71.
2008: Hilvo Mika; Baranauskiene Lina; Salzano Anna Maria; Scaloni Andrea; Matulis Daumantas; Innocenti Alessio; Scozzafava Andrea; Monti Simona Maria; Di Fiore Anna; De Simone Giuseppina; Lindfors Mikaela; Jänis Janne; Valjakka Jarkko; Pastoreková Silvia; Pastorek Jaromir; Kulomaa Markku S; Nordlund Henri R; Supuran Claudiu T; Parkkila Seppo
Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes.
The Journal of biological chemistry 2008;283(41):27799-809.
2008: Hall Rebecca A; Vullo Daniela; Innocenti Alessio; Scozzafava Andrea; Supuran Claudiu T; Klappa Peter; Mühlschlegel Fritz A
External pH influences the transcriptional profile of the carbonic anhydrase, CAH-4b in Caenorhabditis elegans.
Molecular and biochemical parasitology 2008;161(2):140-9.
2008: Temperini Claudia; Innocenti Alessio; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV.
Bioorganic & medicinal chemistry 2008;16(18):8373-8.
2008: Innocenti Alessio; Mühlschlegel Fritz A; Hall Rebecca A; Steegborn Clemens; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with simple anions.
Bioorganic & medicinal chemistry letters 2008;18(18):5066-70.
2008: Maresca Alfonso; Supuran Claudiu T
Muscarinic acetylcholine receptors as therapeutic targets for obesity.
Expert opinion on therapeutic targets 2008;12(9):1167-75.
2008: Moya Aurélie; Tambutté Sylvie; Bertucci Anthony; Tambutté Eric; Lotto Séverine; Vullo Daniela; Supuran Claudiu T; Allemand Denis; Zoccola Didier
Carbonic anhydrase in the scleractinian coral Stylophora pistillata: characterization, localization, and role in biomineralization.
The Journal of biological chemistry 2008;283(37):25475-84.
2008: Woo L W Lawrence; Fischer Delphine S; Sharland Christopher M; Trusselle Melanie; Foster Paul A; Chander Surinder K; Di Fiore Anna; Supuran Claudiu T; De Simone Giuseppina; Purohit Atul; Reed Michael J; Potter Barry V L
Anticancer steroid sulfatase inhibitors: synthesis of a potent fluorinated second-generation agent, in vitro and in vivo activities, molecular modeling, and protein crystallography.
Molecular cancer therapeutics 2008;7(8):2435-44.
2008: Poulsen Sally-Ann; Wilkinson Brendan L; Innocenti Alessio; Vullo Daniela; Supuran Claudiu T
Inhibition of human mitochondrial carbonic anhydrases VA and VB with para-(4-phenyltriazole-1-yl)-benzenesulfonamide derivatives.
Bioorganic & medicinal chemistry letters 2008;18(16):4624-7.
2008: Temperini Claudia; Innocenti Alessio; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies.
Bioorganic & medicinal chemistry letters 2008;18(15):4282-6.
2008: Vullo Daniela; Nishimori Isao; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.
Bioorganic & medicinal chemistry letters 2008;18(15):4303-7.
2008: Innocenti Alessio; Vullo Daniela; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.
Bioorganic & medicinal chemistry 2008;16(15):7424-8.
2008: Temperini Claudia; Cecchi Alessandro; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Sulfonamide diuretics revisited--old leads for new applications?
Organic & biomolecular chemistry 2008;6(14):2499-506.
2008: Innocenti Alessio; Maresca Alfonso; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: thioxolone versus sulfonamides for obtaining isozyme-selective inhibitors?
Bioorganic & medicinal chemistry letters 2008;18(14):3938-41.
2008: Swietach Pawel; Wigfield Simon; Cobden Philip; Supuran Claudiu T; Harris Adrian L; Vaughan-Jones Richard D
Tumor-associated carbonic anhydrase 9 spatially coordinates intracellular pH in three-dimensional multicellular growths.
The Journal of biological chemistry 2008;283(29):20473-83.
2008: Supuran Claudiu T; Di Fiore Anna; De Simone Giuseppina
Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity.
Expert opinion on emerging drugs 2008;13(2):383-92.
2008: Cecchi Alessandro; Ciani Laura; Winum Jean-Yves; Montero Jean-Louis; Scozzafava Andrea; Ristori Sandra; Supuran Claudiu T
Carbonic anhydrase inhibitors: design of spin-labeled sulfonamides incorporating TEMPO moieties as probes for cytosolic or transmembrane isozymes.
Bioorganic & medicinal chemistry letters 2008;18(12):3475-80.
2008: Innocenti Alessio; Hilvo Mika; Scozzafava Andrea; Parkkila Seppo; Supuran Claudiu T
Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols.
Bioorganic & medicinal chemistry letters 2008;18(12):3593-6.
2008: D'Ambrosio Katia; Vitale Rosa-Maria; Dogné Jean-Michel; Masereel Bernard; Innocenti Alessio; Scozzafava Andrea; De Simone Giuseppina; Supuran Claudiu T
Carbonic anhydrase inhibitors: bioreductive nitro-containing sulfonamides with selectivity for targeting the tumor associated isoforms IX and XII.
Journal of medicinal chemistry 2008;51(11):3230-7.
2008: Supuran Claudiu T
Development of small molecule carbonic anhydrase IX inhibitors.
BJU international 2008;101 Suppl 4():39-40.
2008: Swietach Pawel; Wigfield Simon; Supuran Claudiu T; Harris Adrian L; Vaughan-Jones Richard D
Cancer-associated, hypoxia-inducible carbonic anhydrase IX facilitates CO2 diffusion.
BJU international 2008;101 Suppl 4():22-4.
2008: Thiry Anne; Supuran Claudiu T; Masereel Bernard; Dogné Jean-Michel
Recent developments of carbonic anhydrase inhibitors as potential anticancer drugs.
Journal of medicinal chemistry 2008;51(11):3051-6.
2008: Temperini Claudia; Cecchi Alessandro; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.
Bioorganic & medicinal chemistry letters 2008;18(8):2567-73.
2008: Di Fiore Anna; Pedone Carlo; Antel Jochen; Waldeck Harald; Witte Andreas; Wurl Michael; Scozzafava Andrea; Supuran Claudiu T; De Simone Giuseppina
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(8):2669-74.
2008: Innocenti Alessio; Scozzafava Andrea; Parkkila Seppo; Puccetti Luca; De Simone Giuseppina; Supuran Claudiu T
Investigations of the esterase, phosphatase, and sulfatase activities of the cytosolic mammalian carbonic anhydrase isoforms I, II, and XIII with 4-nitrophenyl esters as substrates.
Bioorganic & medicinal chemistry letters 2008;18(7):2267-71.
2008: Chohan Zahid H; Supuran Claudiu T
Structure and biological properties of first row d-transition metal complexes with N-substituted sulfonamides.
Journal of enzyme inhibition and medicinal chemistry 2008;23(2):240-51.
2008: Pastorekova Silvia; Vullo Daniela; Nishimori Isao; Scozzafava Andrea; Pastorek Jaromir; Supuran Claudiu T
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.
Bioorganic & medicinal chemistry 2008;16(7):3530-6.
2008: Saczewski Franciszek; Innocenti Alessio; Slawinski Jaroslaw; Kornicka Anita; Brzozowski Zdzislaw; Pomarnacka Elzbieta; Scozzafava Andrea; Temperini Claudia; Supuran Claudiu T
Carbonic anhydrase inhibitors: inhibition of human cytosolic isozymes I and II and tumor-associated isozymes IX and XII with S-substituted 4-chloro-2-mercapto-5-methyl-benzenesulfonamides.
Bioorganic & medicinal chemistry 2008;16(7):3933-40.
2008: Wilkinson Brendan L; Innocenti Alessio; Vullo Daniela; Supuran Claudiu T; Poulsen Sally-Ann
Inhibition of carbonic anhydrases with glycosyltriazole benzene sulfonamides.
Journal of medicinal chemistry 2008;51(6):1945-53.
2008: Innocenti Alessio; Hilvo Mika; Scozzafava Andrea; Lindfors Mikaela; Nordlund Henri R; Kulomaa Markku S; Parkkila Seppo; Supuran Claudiu T
Carbonic anhydrase inhibitors: the very weak inhibitors dithiothreitol, beta-mercaptoethanol, tris(carboxyethyl)phosphine and threitol interfere with the binding of sulfonamides to isozymes II and IX.
Bioorganic & medicinal chemistry letters 2008;18(6):1898-903.
2008: Leese Mathew P; Jourdan Fabrice L; Gaukroger Keira; Mahon Mary F; Newman Simon P; Foster Paul A; Stengel Chloe; Regis-Lydi Sandra; Ferrandis Eric; Di Fiore Anna; De Simone Giuseppina; Supuran Claudiu T; Purohit Atul; Reed Michael J; Potter Barry V L
Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents.
Journal of medicinal chemistry 2008;51(5):1295-308.
2008: Innocenti Alessio; Vullo Daniela; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV).
Bioorganic & medicinal chemistry letters 2008;18(5):1583-7.
2008: Singh Jyoti; Shaik Basheerulla; Singh Shalini; Agrawal Vijay K; Khadikar Padmakar V; Deeb Omar; Supuran Claudiu T
Comparative QSAR study on para-substituted aromatic sulphonamides as CAII inhibitors: information versus topological (distance-based and connectivity) indices.
Chemical biology & drug design 2008;71(3):244-59.
2008: D'Ambrosio Katia; Masereel Bernard; Thiry Anne; Scozzafava Andrea; Supuran Claudiu T; De Simone Giuseppina
Carbonic anhydrase inhibitors: binding of indanesulfonamides to the human isoform II.
ChemMedChem 2008;3(3):473-7.
2008: Almajan Gabriela Laura; Barbuceanu Stefania-Felicia; Innocenti Alessio; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II and IX with some 1,3,4-oxadiazole- and 1,2,4-triazole-thiols.
Journal of enzyme inhibition and medicinal chemistry 2008;23(1):101-7.
2008: Supuran Claudiu T
Carbonic anhydrases: novel therapeutic applications for inhibitors and activators.
Nature reviews. Drug discovery 2008;7(2):168-81.
2008: Temperini Claudia; Cecchi Alessandro; Boyle Nicholas A; Scozzafava Andrea; Cabeza Jaime Escribano; Wentworth Paul; Blackburn G Michael; Supuran Claudiu T
Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.
Bioorganic & medicinal chemistry letters 2008;18(3):999-1005.
2008: Singh Jyoti; Singh Shalini; Mishra Rajika; Khadikar Padmakar V; Supuran Claudiu T; Clare Brian W; Lakhwani Meenakshi
Estimation of human carbonic anhydrase II inhibition using topological indices and their combination with quantum-theoretical descriptors.
Medicinal chemistry (Shariqah (United Arab Emirates)) 2008;4(1):30-66.
2008: Rami Marouan; Winum Jean-Yves; Innocenti Alessio; Montero Jean-Louis; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: copper(II) complexes of polyamino-polycarboxylamido aromatic/heterocyclic sulfonamides are very potent inhibitors of the tumor-associated isoforms IX and XII.
Bioorganic & medicinal chemistry letters 2008;18(2):836-41.
2008: Barathova M; Takacova M; Holotnakova T; Gibadulinova A; Ohradanova A; Zatovicova M; Hulikova A; Kopacek J; Parkkila S; Supuran C T; Pastorekova S; Pastorek J
Alternative splicing variant of the hypoxia marker carbonic anhydrase IX expressed independently of hypoxia and tumour phenotype.
British journal of cancer 2008;98(1):129-36.
2008: Güzel Ozlen; Temperini Claudia; Innocenti Alessio; Scozzafava Andrea; Salman Aydin; Supuran Claudiu T
Carbonic anhydrase inhibitors. Interaction of 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.
Bioorganic & medicinal chemistry letters 2008;18(1):152-8.
2008: Morishita Saori; Nishimori Isao; Minakuchi Tomoko; Onishi Saburo; Takeuchi Hiroaki; Sugiura Tetsuro; Vullo Daniela; Scozzafava Andrea; Supuran Claudiu T
Cloning, polymorphism, and inhibition of beta-carbonic anhydrase of Helicobacter pylori.
Journal of gastroenterology 2008;43(11):849-57.
2008: Temperini Claudia; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase activation and the drug design.
Current pharmaceutical design 2008;14(7):708-15.
2008: Cecchi Alessandro; Supuran Claudiu T
Fluorescence- and spin-labeled carbonic anhydrase inhibitors.
Current pharmaceutical design 2008;14(7):699-707.
2008: Dogné Jean-Michel; Thiry Anne; Supuran Claudiu T
Carbonic anhydrase inhibition: insight into non-COX-2 pharmacological effect of some coxibs.
Current pharmaceutical design 2008;14(7):679-84.
2008: Hilvo M; Innocenti A; Monti S M; De Simone G; Supuran C T; Parkkila S
Recent advances in research on the most novel carbonic anhydrases, CA XIII and XV.
Current pharmaceutical design 2008;14(7):672-8.
2008: Thiry Anne; Dogné Jean-Michel; Supuran Claudiu T; Masereel Bernard
Anticonvulsant sulfonamides/sulfamates/sulfamides with carbonic anhydrase inhibitory activity: drug design and mechanism of action.
Current pharmaceutical design 2008;14(7):661-71.
2008: De Simone Giuseppina; Di Fiore Anna; Supuran Claudiu T
Are carbonic anhydrase inhibitors suitable for obtaining antiobesity drugs?
Current pharmaceutical design 2008;14(7):655-60.
2008: Mincione Francesco; Scozzafava Andrea; Supuran Claudiu T
The development of topically acting carbonic anhydrase inhibitors as antiglaucoma agents.
Current pharmaceutical design 2008;14(7):649-54.
2008: Supuran Claudiu T
Diuretics: from classical carbonic anhydrase inhibitors to novel applications of the sulfonamides.
Current pharmaceutical design 2008;14(7):641-8.
2008: Krungkrai Jerapan; Supuran Claudiu T
The alpha-carbonic anhydrase from the malaria parasite and its inhibition.
Current pharmaceutical design 2008;14(7):631-40.
2008: Nishimori Isao; Onishi Saburo; Takeuchi Hiroaki; Supuran Claudiu T
The alpha and beta classes carbonic anhydrases from Helicobacter pylori as novel drug targets.
Current pharmaceutical design 2008;14(7):622-30.
2008: Winum Jean-Yves; Scozzafava Andrea; Montero Jean-Louis; Supuran Claudiu T
Design of zinc binding functions for carbonic anhydrase inhibitors.
Current pharmaceutical design 2008;14(7):615-21.
2008: Supuran Claudiu T
Carbonic anhydrases--an overview.
Current pharmaceutical design 2008;14(7):603-14.
2008: Supuran Claudiu T
Carbonic anhydrases as drug targets.
Current pharmaceutical design 2008;14(7):601-2.
2007: Nishimori Isao; Minakuchi Tomoko; Onishi Saburo; Vullo Daniela; Cecchi Alessandro; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides.
Bioorganic & medicinal chemistry 2007;15(23):7229-36.
2007: Tuccinardi Tiziano; Ortore Gabriella; Rossello Armando; Supuran Claudiu T; Martinelli Adriano
Homology modeling and receptor-based 3D-QSAR study of carbonic anhydrase IX.
Journal of chemical information and modeling 2007;47(6):2253-62.
2007: Abdel-Hamid Mohammed K; Abdel-Hafez Atef A; El-Koussi Nawal A; Mahfouz Nadia M; Innocenti Alessio; Supuran Claudiu T
Design, synthesis, and docking studies of new 1,3,4-thiadiazole-2-thione derivatives with carbonic anhydrase inhibitory activity.
Bioorganic & medicinal chemistry 2007;15(22):6975-84.
2007: Nishimori Isao; Innocenti Alessio; Vullo Daniela; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: the inhibition profiles of the human mitochondrial isoforms VA and VB with anions are very different.
Bioorganic & medicinal chemistry 2007;15(21):6742-7.
2007: Singh Jyoti; Shaik Basheerulla; Singh Shalini; Sikhima Sarla; Agrawal Vijay K; Khadikar Padmakar V; Supuran Claudiu T
QSAR studies on the activation of the human carbonic anhydrase cytosolic isoforms I and II and secretory isozyme VI with amino acids and amines.
Bioorganic & medicinal chemistry 2007;15(20):6501-9.
2007: Ohradanova Anna; Vullo Daniela; Kopacek Juraj; Temperini Claudia; Betakova Tatiana; Pastorekova Silvia; Pastorek Jaromir; Supuran Claudiu T
Reconstitution of carbonic anhydrase activity of the cell-surface-binding protein of vaccinia virus.
The Biochemical journal 2007;407(1):61-7.
2007: Salmon Adam J; Williams Michael L; Innocenti Alessio; Vullo Daniela; Supuran Claudiu T; Poulsen Sally-Ann
Inhibition of carbonic anhydrase isozymes I, II and IX with benzenesulfonamides containing an organometallic moiety.
Bioorganic & medicinal chemistry letters 2007;17(18):5032-5.
2007: Colinas Pedro A; Bravo Rodolfo D; Vullo Daniela; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I and II, and extracellular isoforms IV, IX, and XII with sulfamides incorporating sugar moieties.
Bioorganic & medicinal chemistry letters 2007;17(18):5086-90.
2007: Smaine Fatma-Zohra; Winum Jean-Yves; Montero Jean-Louis; Regainia Zine; Vullo Daniela; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: Selective inhibition of the extracellular, tumor-associated isoforms IX and XII over isozymes I and II with glycosyl-thioureido-sulfonamides.
Bioorganic & medicinal chemistry letters 2007;17(18):5096-100.
2007: Thiry Anne; Masereel Bernard; Dogné Jean-Michel; Supuran Claudiu T; Wouters Johan; Michaux Catherine
Exploration of the binding mode of indanesulfonamides as selective inhibitors of human carbonic anhydrase type VII by targeting Lys 91.
ChemMedChem 2007;2(9):1273-80.
2007: Temperini Claudia; Innocenti Alessio; Mastrolorenzo Antonio; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Interaction of the antiepileptic drug sulthiame with twelve mammalian isoforms: kinetic and X-ray crystallographic studies.
Bioorganic & medicinal chemistry letters 2007;17(17):4866-72.
2007: Tarko Laszlo; Supuran Claudiu T
QSAR studies for the inhibition of the transmembrane isozymes XII and XIV of human carbonic anhydrase with a series of sulfonamides.
Bioorganic & medicinal chemistry 2007;15(17):5666-71.
2007: Alterio Vincenzo; De Simone Giuseppina; Monti Simona Maria; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.
Bioorganic & medicinal chemistry letters 2007;17(15):4201-7.
2007: Vullo Daniela; Innocenti Alessio; Nishimori Isao; Scozzafava Andrea; Kaila Kai; Supuran Claudiu T
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.
Bioorganic & medicinal chemistry letters 2007;17(15):4107-12.
2007: Nishimori Isao; Onishi Saburo; Vullo Daniela; Innocenti Alessio; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.
Bioorganic & medicinal chemistry 2007;15(15):5351-7.
2007: Nishimori Isao; Minakuchi Tomoko; Kohsaki Takuhiro; Onishi Saburo; Takeuchi Hiroaki; Vullo Daniela; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(13):3585-94.
2007: Supuran Claudiu T; Scozzafava Andrea
Carbonic anhydrases as targets for medicinal chemistry.
Bioorganic & medicinal chemistry 2007;15(13):4336-50.
2007: Zareef Muhammad; Iqbal Rashid; De Dominguez Neira Gamboa; Rodrigues Juan; Zaidi Javid H; Arfan Muhammad; Supuran Claudiu T
Synthesis and antimalarial activity of novel chiral and achiral benzenesulfonamides bearing 1, 3, 4-oxadiazole moieties.
Journal of enzyme inhibition and medicinal chemistry 2007;22(3):301-8.
2007: Dubois Ludwig; Douma Kim; Supuran Claudiu T; Chiu Roland K; van Zandvoort Marc A M J; Pastoreková Silvia; Scozzafava Andrea; Wouters Bradly G; Lambin Philippe
Imaging the hypoxia surrogate marker CA IX requires expression and catalytic activity for binding fluorescent sulfonamide inhibitors.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2007;83(3):367-73.
2007: Vitale Rosa Maria; Pedone Carlo; Amodeo Pietro; Antel Jochen; Wurl Michael; Scozzafava Andrea; Supuran Claudiu T; De Simone Giuseppina
Molecular modeling study for the binding of zonisamide and topiramate to the human mitochondrial carbonic anhydrase isoform VA.
Bioorganic & medicinal chemistry 2007;15(12):4152-8.
2007: Winum Jean-Yves; Thiry Anne; Cheikh Khaled El; Dogné Jean-Michel; Montero Jean-Louis; Vullo Daniela; Scozzafava Andrea; Masereel Bernard; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of isoforms I, II, IV, VA, VII, IX, and XIV with sulfonamides incorporating fructopyranose-thioureido tails.
Bioorganic & medicinal chemistry letters 2007;17(10):2685-91.
2007: Temperini Claudia; Winum Jean-Yves; Montero Jean-Louis; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: the X-ray crystal structure of the adduct of N-hydroxysulfamide with isozyme II explains why this new zinc binding function is effective in the design of potent inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(10):2795-801.
2007: Wilkinson Brendan L; Bornaghi Laurent F; Houston Todd A; Innocenti Alessio; Vullo Daniela; Supuran Claudiu T; Poulsen Sally-Ann
Carbonic anhydrase inhibitors: inhibition of isozymes I, II, and IX with triazole-linked O-glycosides of benzene sulfonamides.
Journal of medicinal chemistry 2007;50(7):1651-7.
2007: Temperini Claudia; Innocenti Alessio; Guerri Annalisa; Scozzafava Andrea; Rusconi Stefano; Supuran Claudiu T
Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I.
Bioorganic & medicinal chemistry letters 2007;17(8):2210-5.
2007: Riihonen Riikka; Supuran Claudiu T; Parkkila Seppo; Pastorekova Silvia; Väänänen H Kalervo; Laitala-Leinonen Tiina
Membrane-bound carbonic anhydrases in osteoclasts.
Bone 2007;40(4):1021-31.
2007: Tuccinardi Tiziano; Nuti Elisa; Ortore Gabriella; Supuran Claudiu T; Rossello Armando; Martinelli Adriano
Analysis of human carbonic anhydrase II: docking reliability and receptor-based 3D-QSAR study.
Journal of chemical information and modeling 2007;47(2):515-25.
2007: Nuti Elisa; Orlandini Elisabetta; Nencetti Susanna; Rossello Armando; Innocenti Alessio; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with sulfonylated hydroxamates.
Bioorganic & medicinal chemistry 2007;15(6):2298-311.
2007: Innocenti Alessio; Vullo Daniela; Pastorek Jaromir; Scozzafava Andrea; Pastorekova Silvia; Nishimori Isao; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of transmembrane isozymes XII (cancer-associated) and XIV with anions.
Bioorganic & medicinal chemistry letters 2007;17(6):1532-7.
2007: Santos M Amelia; Marques Sergio; Vullo Daniela; Innocenti Alessio; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated isoforms I, II, and IX with iminodiacetic carboxylates/hydroxamates also incorporating benzenesulfonamide moieties.
Bioorganic & medicinal chemistry letters 2007;17(6):1538-43.
2007: Di Fiore Anna; Scozzafava Andrea; Winum Jean-Yves; Montero Jean-Louis; Pedone Carlo; Supuran Claudiu T; De Simone Giuseppina
Carbonic anhydrase inhibitors: binding of an antiglaucoma glycosyl-sulfanilamide derivative to human isoform II and its consequences for the drug design of enzyme inhibitors incorporating sugar moieties.
Bioorganic & medicinal chemistry letters 2007;17(6):1726-31.
2007: Vullo Daniela; Nishimori Isao; Innocenti Alessio; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase activators: an activation study of the human mitochondrial isoforms VA and VB with amino acids and amines.
Bioorganic & medicinal chemistry letters 2007;17(5):1336-40.
2007: Wilkinson Brendan L; Bornaghi Laurent F; Houston Todd A; Innocenti Alessio; Vullo Daniela; Supuran Claudiu T; Poulsen Sally-Ann
Inhibition of membrane-associated carbonic anhydrase isozymes IX, XII and XIV with a library of glycoconjugate benzenesulfonamides.
Bioorganic & medicinal chemistry letters 2007;17(4):987-92.
2007: Nishimori Isao; Innocenti Alessio; Vullo Daniela; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition studies of the human secretory isoform VI with anions.
Bioorganic & medicinal chemistry letters 2007;17(4):1037-42.
2007: Temperini Claudia; Innocenti Alessio; Scozzafava Andrea; Mastrolorenzo Antonio; Supuran Claudiu T
Carbonic anhydrase activators: L-Adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII, and XIV.
Bioorganic & medicinal chemistry letters 2007;17(3):628-35.
2007: Nishimori Isao; Minakuchi Tomoko; Onishi Saburo; Vullo Daniela; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.
Journal of medicinal chemistry 2007;50(2):381-8.
2007: Casini Angela; Mastrobuoni Guido; Temperini Claudia; Gabbiani Chiara; Francese Simona; Moneti Gloriano; Supuran Claudiu T; Scozzafava Andrea; Messori Luigi
ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme.
Chemical communications (Cambridge, England) 2007;(2):156-8.
2007: Mastrolorenzo Antonio; Rusconi Stefano; Scozzafava Andrea; Barbaro Giuseppe; Supuran Claudiu T
Inhibitors of HIV-1 protease: current state of the art 10 years after their introduction. From antiretroviral drugs to antifungal, antibacterial and antitumor agents based on aspartic protease inhibitors.
Current medicinal chemistry 2007;14(26):2734-48.
2007: Köhler Karen; Hillebrecht Alexander; Schulze Wischeler Johannes; Innocenti Alessio; Heine Andreas; Supuran Claudiu T; Klebe Gerhard
Saccharin inhibits carbonic anhydrases: possible explanation for its unpleasant metallic aftertaste.
Angewandte Chemie (International ed. in English) 2007;46(40):7697-9.
2007: Rusconi Stefano; Scozzafava Andrea; Mastrolorenzo Antonio; Supuran Claudiu T
An update in the development of HIV entry inhibitors.
Current topics in medicinal chemistry 2007;7(13):1273-89.
2007: Krungkrai Jerapan; Krungkrai Sudaratana R; Supuran Claudiu T
Malarial parasite carbonic anhydrase and its inhibitors.
Current topics in medicinal chemistry 2007;7(9):909-17.
2007: Zimmerman Sabrina A; Ferry James G; Supuran Claudiu T
Inhibition of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases.
Current topics in medicinal chemistry 2007;7(9):901-8.
2007: Hilvo Mika; Supuran Claudiu T; Parkkila Seppo
Characterization and inhibition of the recently discovered carbonic anhydrase isoforms CA XIII, XIV and XV.
Current topics in medicinal chemistry 2007;7(9):893-9.
2007: Dogné Jean-Michel; Thiry Anne; Pratico Domenico; Masereel Bernard; Supuran Claudiu T
Dual carbonic anhydrase--cyclooxygenase-2 inhibitors.
Current topics in medicinal chemistry 2007;7(9):885-91.
2007: De Simone Giuseppina; Supuran Claudiu T
Antiobesity carbonic anhydrase inhibitors.
Current topics in medicinal chemistry 2007;7(9):879-84.
2007: Thiry Anne; Dogné Jean-Michel; Supuran Claudiu T; Masereel Bernard
Carbonic anhydrase inhibitors as anticonvulsant agents.
Current topics in medicinal chemistry 2007;7(9):855-64.
2007: Mincione Francesco; Scozzafava Andrea; Supuran Claudiu T
The development of topically acting carbonic anhydrase inhibitors as anti-glaucoma agents.
Current topics in medicinal chemistry 2007;7(9):849-54.
2007: Winum Jean-Yves; Scozzafava Andrea; Montero Jean-Louis; Supuran Claudiu T
Metal binding functions in the design of carbonic anhydrase inhibitors.
Current topics in medicinal chemistry 2007;7(9):835-48.
2007: Supuran Claudiu T
Carbonic anhydrases as drug targets--an overview.
Current topics in medicinal chemistry 2007;7(9):825-33.
2006: Chohan Zahid H; Shaikh Ali U; Naseer Muhammad M; Supuran Claudiu T
In-vitro antibacterial, antifungal and cytotoxic properties of metal-based furanyl derived sulfonamides.
Journal of enzyme inhibition and medicinal chemistry 2006;21(6):771-81.
2006: Chohan Zahid H; Shaikh Ali U; Rauf Abdul; Supuran Claudiu T
Antibacterial, antifungal and cytotoxic properties of novel N-substituted sulfonamides from 4-hydroxycoumarin.
Journal of enzyme inhibition and medicinal chemistry 2006;21(6):741-8.
2006: Chohan Zahid H; Shaikh Ali U; Supuran Claudiu T
In-vitro antibacterial, antifungal and cytotoxic activity of cobalt (II), copper (II), nickel (II) and zinc (II) complexes with furanylmethyl- and thienylmethyl-dithiolenes: [1, 3-dithiole- 2-one and 1,3-dithiole-2-thione].
Journal of enzyme inhibition and medicinal chemistry 2006;21(6):733-40.
2006: Leese Mathew P; Leblond Bertrand; Smith Andrew; Newman Simon P; Di Fiore Anna; De Simone Giuseppina; Supuran Claudiu T; Purohit Atul; Reed Michael J; Potter Barry V L
2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity.
Journal of medicinal chemistry 2006;49(26):7683-96.
2006: Menchise Valeria; De Simone Giuseppina; Di Fiore Anna; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of 5-amino-1,3,4-thiadiazole-2-sulfonamide and 5-(4-amino-3-chloro-5-fluorophenylsulfonamido)-1,3,4-thiadiazole-2-sulfonamide to human isoform II.
Bioorganic & medicinal chemistry letters 2006;16(24):6204-8.
2006: Winum Jean-Yves; Temperini Claudia; El Cheikh Khaled; Innocenti Alessio; Vullo Daniela; Ciattini Samuele; Montero Jean-Louis; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.
Journal of medicinal chemistry 2006;49(24):7024-31.
2006: Weber Alexander; Böhm Markus; Supuran Claudiu T; Scozzafava Andrea; Sotriffer Christoph A; Klebe Gerhard
3D QSAR selectivity analyses of carbonic anhydrase inhibitors: insights for the design of isozyme selective inhibitors.
Journal of chemical information and modeling 2006;46(6):2737-60.
2006: Wilkinson Brendan L; Bornaghi Laurent F; Houston Todd A; Innocenti Alessio; Supuran Claudiu T; Poulsen Sally-Ann
A novel class of carbonic anhydrase inhibitors: glycoconjugate benzene sulfonamides prepared by "click-tailing".
Journal of medicinal chemistry 2006;49(22):6539-48.
2006: Thiry Anne; Dogné Jean-Michel; Masereel Bernard; Supuran Claudiu T
Targeting tumor-associated carbonic anhydrase IX in cancer therapy.
Trends in pharmacological sciences 2006;27(11):566-73.
2006: Winum Jean-Yves; Scozzafava Andrea; Montero Jean-Louis; Supuran Claudiu T
Therapeutic potential of sulfamides as enzyme inhibitors.
Medicinal research reviews 2006;26(6):767-92.
2006: Saczewski Franciszek; Innocenti Alessio; Brzozowski Zdzislaw; Slawinski Jaroslaw; Pomarnacka Elzbieta; Kornicka Anita; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Selective inhibition of human tumor-associated isozymes IX and XII and cytosolic isozymes I and II with some substituted-2-mercapto-benzenesulfonamides.
Journal of enzyme inhibition and medicinal chemistry 2006;21(5):563-8.
2006: Temperini Claudia; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase activators: the first X-ray crystallographic study of an adduct of isoform I.
Bioorganic & medicinal chemistry letters 2006;16(19):5152-6.
2006: De Simone Giuseppina; Vitale Rosa Maria; Di Fiore Anna; Pedone Carlo; Scozzafava Andrea; Montero Jean-Louis; Winum Jean-Yves; Supuran Claudiu T
Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX.
Journal of medicinal chemistry 2006;49(18):5544-51.
2006: Saczewski Franciszek; Slawinski Jaroslaw; Kornicka Anita; Brzozowski Zdzislaw; Pomarnacka Elzbieta; Innocenti Alessio; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of the cytosolic human isozymes I and II, and the transmembrane, tumor-associated isozymes IX and XII with substituted aromatic sulfonamides activatable in hypoxic tumors.
Bioorganic & medicinal chemistry letters 2006;16(18):4846-51.
2006: Temperini Claudia; Scozzafava Andrea; Vullo Daniela; Supuran Claudiu T
Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with l- and d-histidine and crystallographic analysis of their adducts with isoform II: engineering proton-transfer processes within the active site of an enzyme.
Chemistry (Weinheim an der Bergstrasse, Germany) 2006;12(27):7057-66.
2006: Winum Jean-Yves; Cecchi Alessandro; Seridi Achour; Scozzafava Andrea; Montero Jean-Louis; Supuran Claudiu T
Carbonic anhydrase inhibitors. N-cyanomethylsulfonamides--a new zinc binding group in the design of inhibitors targeting cytosolic and membrane-anchored isoforms.
Journal of enzyme inhibition and medicinal chemistry 2006;21(4):477-81.
2006: Chohan Zahid H; Supuran Claudiu T
Metalloantibiotics: synthesis, characterization and in-vitro antibacterial studies on cobalt (II), copper (II), nickel (II) and zinc (II) complexes with cloxacillin.
Journal of enzyme inhibition and medicinal chemistry 2006;21(4):441-8.
2006: Zareef Muhammad; Innocenti Alessio; Iqbal Rashid; Zaidi Javid H; Arfan Muhammad; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozymes I and II with some 1,3,4-oxadiazole-thiols.
Journal of enzyme inhibition and medicinal chemistry 2006;21(4):351-9.
2006: Winum Jean-Yves; Scozzafava Andrea; Montero Jean-Louis; Supuran Claudiu T
New zinc binding motifs in the design of selective carbonic anhydrase inhibitors.
Mini reviews in medicinal chemistry 2006;6(8):921-36.
2006: Hillebrecht Alexander; Supuran Claudiu T; Klebe Gerhard
Integrated approach using protein and ligand information to analyze selectivity- and affinity-determining features of carbonic anhydrase isozymes.
ChemMedChem 2006;1(8):839-53.
2006: Temperini Claudia; Innocenti Alessio; Scozzafava Andrea; Supuran Claudiu T
N-hydroxyurea--a versatile zinc binding function in the design of metalloenzyme inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(16):4316-20.
2006: Parkkila Seppo; Vullo Daniela; Puccetti Luca; Parkkila Anna-Kaisa; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines.
Bioorganic & medicinal chemistry letters 2006;16(15):3955-9.
2006: Ozensoy Ozen; Kockar Feray; Arslan Oktay; Isik Semra; Supuran Claudiu T; Lyon Malcolm
An evaluation of cytosolic erythrocyte carbonic anhydrase and catalase in carcinoma patients: an elevation of carbonic anhydrase activity.
Clinical biochemistry 2006;39(8):804-9.
2006: Alterio Vincenzo; Vitale Rosa Maria; Monti Simona Maria; Pedone Carlo; Scozzafava Andrea; Cecchi Alessandro; De Simone Giuseppina; Supuran Claudiu T
Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX.
Journal of the American Chemical Society 2006;128(25):8329-35.
2006: Vullo Daniela; Ruusuvuori Eva; Kaila Kai; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: inhibition of the cytosolic human isozyme VII with anions.
Bioorganic & medicinal chemistry letters 2006;16(12):3139-43.
2006: Mizumori Misa; Meyerowitz Justin; Takeuchi Tetsu; Lim Shu; Lee Paul; Supuran Claudiu T; Guth Paul H; Engel Eli; Kaunitz Jonathan D; Akiba Yasutada
Epithelial carbonic anhydrases facilitate PCO2 and pH regulation in rat duodenal mucosa.
The Journal of physiology 2006;573(Pt 3):827-42.
2006: Temperini Claudia; Scozzafava Andrea; Vullo Daniela; Supuran Claudiu T
Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII, and XIV with L- and D-phenylalanine and crystallographic analysis of their adducts with isozyme II: stereospecific recognition within the active site of an enzyme and its consequences for the drug design.
Journal of medicinal chemistry 2006;49(10):3019-27.
2006: Thiry Anne; Ledecq Marie; Cecchi Alessandro; Dogné Jean-Michel; Wouters Johan; Supuran Claudiu T; Masereel Bernard
Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX.
Journal of medicinal chemistry 2006;49(9):2743-9.
2006: Chohan Zahid H; Pervez Humayun; Rauf Abdul; Khan Khalid M; Supuran Claudiu T
Antibacterial cobalt (II), copper (II), nickel (II) and zinc (II) complexes of mercaptothiadiazole--derived furanyl, thienyl, pyrrolyl, salicylyl and pyridinyl Schiff bases.
Journal of enzyme inhibition and medicinal chemistry 2006;21(2):193-201.
2006: Chohan Zahid H; Rauf Abdul; Naseer Muhammad M; Somra Muhammad A; Supuran Claudiu T
Antibacterial, antifungal and cytotoxic properties of some sulfonamide-derived chromones.
Journal of enzyme inhibition and medicinal chemistry 2006;21(2):173-7.
2006: Simi Lisa; Venturini Giulia; Malentacchi Francesca; Gelmini Stefania; Andreani Matteo; Janni Alberto; Pastorekova Silvia; Supuran Claudiu T; Pazzagli Mario; Orlando Claudio
Quantitative analysis of carbonic anhydrase IX mRNA in human non-small cell lung cancer.
Lung cancer (Amsterdam, Netherlands) 2006;52(1):59-66.
2006: Nishimori Isao; Vullo Daniela; Minakuchi Tomoko; Morimoto Kaori; Onishi Saburo; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori.
Bioorganic & medicinal chemistry letters 2006;16(8):2182-8.
2006: Agrawal Vijay K; Singh Jyoti; Khadikar Padmakar V; Supuran Claudiu T
QSAR study on topically acting sulfonamides incorporating GABA moieties: a molecular connectivity approach.
Bioorganic & medicinal chemistry letters 2006;16(7):2044-51.
2006: Vullo Daniela; Steffansen Bente; Brodin Birger; Supuran Claudiu T; Scozzafava Andrea; Nielsen Carsten Uhd
Carbonic anhydrase inhibitors: transepithelial transport of thioureido sulfonamide inhibitors of the cancer-associated isozyme IX is dependent on efflux transporters.
Bioorganic & medicinal chemistry 2006;14(7):2418-27.
2006: Nishimori Isao; Minakuchi Tomoko; Morimoto Kaori; Sano Shuichi; Onishi Saburo; Takeuchi Hiroaki; Vullo Daniela; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs.
Journal of medicinal chemistry 2006;49(6):2117-26.
2006: Agrawal Vijay K; Singh Jyoti; Gupta Madhu; Jaliwala Yusuf Ali; Khadikar Padmakar V; Supuran Claudiu T
QSAR studies on benzopyran potassium channel activators.
European journal of medicinal chemistry 2006;41(3):360-6.
2006: Clare Brian W; Supuran Claudiu T
A perspective on quantitative structure-activity relationships and carbonic anhydrase inhibitors.
Expert opinion on drug metabolism & toxicology 2006;2(1):113-37.
2006: Chohan Zahid H; Arif M; Shafiq Zahid; Yaqub Muhammad; Supuran Claudiu T
In vitro antibacterial, antifungal & cytotoxic activity of some isonicotinoylhydrazide Schiff's bases and their cobalt (II), copper (II), nickel (II) and zinc (II) complexes.
Journal of enzyme inhibition and medicinal chemistry 2006;21(1):95-103.
2006: Maqsood Zahida T; Khan Khalid M; Ashiq Uzma; Jamal Rifat A; Chohan Zahid H; Mahroof-Tahir Mohammad; Supuran Claudiu T
Oxovanadium(IV) complexes of hydrazides: potential antifungal agents.
Journal of enzyme inhibition and medicinal chemistry 2006;21(1):37-42.
2006: Mastrolorenzo Antonio; Tiradritti Luana; Vichi Francesca; Ketabchi Sheyda; Supuran Claudiu T; Zuccati Giuliano
Primary anetoderma and HIV infection: a case report.
The AIDS reader 2006;16(2):92-6; discussion 94-5.
2006: Melagraki Georgia; Afantitis Antreas; Sarimveis Haralambos; Igglessi-Markopoulou Olga; Supuran Claudiu T
QSAR study on para-substituted aromatic sulfonamides as carbonic anhydrase II inhibitors using topological information indices.
Bioorganic & medicinal chemistry 2006;14(4):1108-14.
2006: Di Fiore Anna; Pedone Carlo; D'Ambrosio Katia; Scozzafava Andrea; De Simone Giuseppina; Supuran Claudiu T
Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II "selective" inhibitor celecoxib.
Bioorganic & medicinal chemistry letters 2006;16(2):437-42.
2006: Chohan Zahid H; Arif M; Akhtar Muhammad A; Supuran Claudiu T
Metal-Based Antibacterial and Antifungal Agents: Synthesis, Characterization, and In Vitro Biological Evaluation of Co(II), Cu(II), Ni(II), and Zn(II) Complexes With Amino Acid-Derived Compounds.
Bioinorganic chemistry and applications 2006;():83131.
2006: Supuran Claudiu T; Mastrolorenzo Antonio; Barbaro Giuseppe; Scozzafava Andrea
Phosphodiesterase 5 inhibitors--drug design and differentiation based on selectivity, pharmacokinetic and efficacy profiles.
Current pharmaceutical design 2006;12(27):3459-65.
2005: Nishimori Isao; Vullo Daniela; Innocenti Alessio; Scozzafava Andrea; Mastrolorenzo Antonio; Supuran Claudiu T
Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors.
Journal of medicinal chemistry 2005;48(24):7860-6.
2005: Temperini Claudia; Scozzafava Andrea; Puccetti Luca; Supuran Claudiu T
Carbonic anhydrase activators: X-ray crystal structure of the adduct of human isozyme II with L-histidine as a platform for the design of stronger activators.
Bioorganic & medicinal chemistry letters 2005;15(23):5136-41.
2005: Cecchi Alessandro; Taylor Scott D; Liu Yong; Hill Bryan; Vullo Daniela; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides.
Bioorganic & medicinal chemistry letters 2005;15(23):5192-6.
2005: Ozensoy Ozen; Puccetti Luca; Fasolis Giuseppe; Arslan Oktay; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides.
Bioorganic & medicinal chemistry letters 2005;15(21):4862-6.
2005: Innocenti Alessio; Villar Raquel; Martinez-Merino Victor; Gil María J; Scozzafava Andrea; Vullo Daniela; Supuran Claudiu T
Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with benzo[b]thiophene 1,1-dioxide sulfonamides.
Bioorganic & medicinal chemistry letters 2005;15(21):4872-6.
2005: Ozensoy Ozen; Nishimori Isao; Vullo Daniela; Puccetti Luca; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: inhibition of the human transmembrane isozyme XIV with a library of aromatic/heterocyclic sulfonamides.
Bioorganic & medicinal chemistry 2005;13(22):6089-93.
2005: Chohan Zahid H; Supuran Claudiu T
In-vitro antibacterial and cytotoxic activity of cobalt (ii), copper (ii), nickel (ii) and zinc (ii) complexes of the antibiotic drug cephalothin (Keflin).
Journal of enzyme inhibition and medicinal chemistry 2005;20(5):463-8.
2005: Agrawal Vijay K; Banerji Meghna; Gupta Madhu; Singh Jyoti; Khadikar Padmakar V; Supuran Claudiu T
QSAR study on carbonic anhydrase inhibitors: water-soluble sulfonamides incorporating beta-alanyl moieties, possessing long lasting-intra ocular pressure lowering properties--a molecular connectivity approach.
European journal of medicinal chemistry 2005;40(10):1002-12.
2005: Clare Brian W; Supuran Claudiu T
Predictive flip regression: a technique for QSAR of derivatives of symmetric molecules.
Journal of chemical information and modeling 2005;45(5):1385-91.
2005: Menchise Valeria; De Simone Giuseppina; Alterio Vincenzo; Di Fiore Anna; Pedone Carlo; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II.
Journal of medicinal chemistry 2005;48(18):5721-7.
2005: Balaban Alexandru T; Khadikar Padmakar V; Supuran Claudiu T; Thakur Abhilash; Thakur Mamta
Study on supramolecular complexing ability vis-à-vis estimation of pKa of substituted sulfonamides: dominating role of Balaban index (J).
Bioorganic & medicinal chemistry letters 2005;15(17):3966-73.
2005: Mincione Francesco; Starnotti Michele; Masini Emanuela; Bacciottini Lucia; Scrivanti Chiara; Casini Angela; Vullo Daniela; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma.
Bioorganic & medicinal chemistry letters 2005;15(17):3821-7.
2005: Nishimori Isao; Vullo Daniela; Innocenti Alessio; Scozzafava Andrea; Mastrolorenzo Antonio; Supuran Claudiu T
Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.
Bioorganic & medicinal chemistry letters 2005;15(17):3828-33.
2005: Khan Khalid M; Saify Zafar S; Khan Mahmud T H; Butt Naeem; Maharvi Ghulam M; Perveen Shahnaz; Ambreen Nida; Choudhary Muhammad I; Atta-Ur-Rahman; Supuran Claudiu T
Tyrosinase inhibition: conformational analysis based studies on molecular dynamics calculations of bipiperidine based inhibitors.
Journal of enzyme inhibition and medicinal chemistry 2005;20(4):401-7.
2005: Ozensoy Ozen; Isik Semra; Arslan Oktay; Arslan Mikail; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of red blood cell ostrich (Struthio camelus) carbonic anhydrase with a series of aromatic and heterocyclic sulfonamides.
Journal of enzyme inhibition and medicinal chemistry 2005;20(4):383-7.
2005: Rehman Saeed U; Chohan Zahid H; Gulnaz Farzana; Supuran Claudiu T
In-vitro antibacterial, antifungal and cytotoxic activities of some coumarins and their metal complexes.
Journal of enzyme inhibition and medicinal chemistry 2005;20(4):333-40.
2005: Puccetti Luca; Supuran Claudiu T; Fasolo Pier P; Conti Enrico; Sebastiani Giancarlo; Lacquaniti Sergio; Mandras Roberto; Milazzo Maria G; Dogliani Natalia; De Giuli Paolo; Fasolis Giuseppe
Skewing towards neuroendocrine phenotype in high grade or high stage androgen-responsive primary prostate cancer.
European urology 2005;48(2):215-21; Discussion 221-3.
2005: Cecchi Alessandro; Hulikova Alzbeta; Pastorek Jaromír; Pastoreková Silvia; Scozzafava Andrea; Winum Jean-Yves; Montero Jean-Louis; Supuran Claudiu T
Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors.
Journal of medicinal chemistry 2005;48(15):4834-41.
2005: Winum Jean-Yves; Cecchi Alessandro; Montero Jean-Louis; Innocenti Alessio; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with boron-containing sulfonamides, sulfamides, and sulfamates: toward agents for boron neutron capture therapy of hypoxic tumors.
Bioorganic & medicinal chemistry letters 2005;15(13):3302-6.
2005: Chohan Zahid H; Supuran Claudiu T; Scozzafava Andrea
Metal binding and antibacterial activity of ciprofloxacin complexes.
Journal of enzyme inhibition and medicinal chemistry 2005;20(3):303-7.
2005: Dar Ahsana; Khan Khalid M; Ateeq Humayun S; Khan Shagufta; Rahat Shagufta; Perveen Shahnaz; Supuran Claudiu T
Inhibition of monoamine oxidase-A activity in rat brain by synthetic hydrazines: structure-activity relationship (SAR).
Journal of enzyme inhibition and medicinal chemistry 2005;20(3):269-74.
2005: Pastorekova Silvia; Vullo Daniela; Casini Angela; Scozzafava Andrea; Pastorek Jaromir; Nishimori Isao; Supuran Claudiu T
Carbonic anhydrase inhibitors: Inhibition of the tumor-associated isozymes IX and XII with polyfluorinated aromatic/heterocyclic sulfonamides.
Journal of enzyme inhibition and medicinal chemistry 2005;20(3):211-7.
2005: Puccetti Luca; Fasolis Giuseppe; Vullo Daniela; Chohan Zahid H; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with Schiff's bases incorporating chromone and aromatic sulfonamide moieties, and their zinc complexes.
Bioorganic & medicinal chemistry letters 2005;15(12):3096-101.
2005: Garaj Vladimir; Puccetti Luca; Fasolis Giuseppe; Winum Jean-Yves; Montero Jean-Louis; Scozzafava Andrea; Vullo Daniela; Innocenti Alessio; Supuran Claudiu T
Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX.
Bioorganic & medicinal chemistry letters 2005;15(12):3102-8.
2005: Puccetti Luca; Fasolis Giuseppe; Cecchi Alessandro; Winum Jean-Yves; Gamberi Alessandro; Montero Jean-Louis; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds.
Bioorganic & medicinal chemistry letters 2005;15(9):2359-64.
2005: Winum Jean-Yves; Innocenti Alessio; Nasr Jihane; Montero Jean-Louis; Scozzafava Andrea; Vullo Daniela; Supuran Claudiu T
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxysulfamides--a new zinc-binding function in the design of inhibitors.
Bioorganic & medicinal chemistry letters 2005;15(9):2353-8.
2005: Almajan Gabriela Laura; Innocenti Alessio; Puccetti Luca; Manole Gheorghe; Barbuceanu Stefania; Saramet Ioana; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II, and IX with a series of 1,3,4-thiadiazole- and 1,2,4-triazole-thiols.
Bioorganic & medicinal chemistry letters 2005;15(9):2347-52.
2005: De Simone Giuseppina; Di Fiore Anna; Menchise Valeria; Pedone Carlo; Antel Jochen; Casini Angela; Scozzafava Andrea; Wurl Michael; Supuran Claudiu T
Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies.
Bioorganic & medicinal chemistry letters 2005;15(9):2315-20.
2005: Chohan Zahid H; Mahmood-Ul-Hassan; Khan Khalid M; Supuran Claudiu T
In-vitro antibacterial, antifungal and cytotoxic properties of sulfonamide--derived Schiff's bases and their metal complexes.
Journal of enzyme inhibition and medicinal chemistry 2005;20(2):183-8.
2005: Dogné Jean-Michel; Supuran Claudiu T; Pratico Domenico
Adverse cardiovascular effects of the coxibs.
Journal of medicinal chemistry 2005;48(7):2251-7.
2005: Di Fiore Anna; De Simone Giuseppina; Menchise Valeria; Pedone Carlo; Casini Angela; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: X-ray crystal structure of a benzenesulfonamide strong CA II and CA IX inhibitor bearing a pentafluorophenylaminothioureido tail in complex with isozyme II.
Bioorganic & medicinal chemistry letters 2005;15(7):1937-42.
2005: Innocenti Alessio; Antel Jochen; Wurl Michael; Vullo Daniela; Firnges Michael A; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V and IX with complex fluorides, chlorides and cyanides.
Bioorganic & medicinal chemistry letters 2005;15(7):1909-13.
2005: Winum Jean-Yves; Dogné Jean-Michel; Casini Angela; de Leval Xavier; Montero Jean-Louis; Scozzafava Andrea; Vullo Daniela; Innocenti Alessio; Supuran Claudiu T
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating hydrazino moieties.
Journal of medicinal chemistry 2005;48(6):2121-5.
2005: Winum Jean-Yves; Innocenti Alessio; Gagnard Valerie; Montero Jean-Louis; Scozzafava Andrea; Vullo Daniela; Supuran Claudiu T
Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with organic phosphates and phosphonates.
Bioorganic & medicinal chemistry letters 2005;15(6):1683-6.
2005: Clare Brian W; Supuran Claudiu T
A physically interpretable quantum-theoretic QSAR for some carbonic anhydrase inhibitors with diverse aromatic rings, obtained by a new QSAR procedure.
Bioorganic & medicinal chemistry 2005;13(6):2197-211.
2005: Winum Jean-Yves; Scozzafava Andrea; Montero Jean-Louis; Supuran Claudiu T
Sulfamates and their therapeutic potential.
Medicinal research reviews 2005;25(2):186-228.
2005: Chohan Zahid H; Pervez Humayun; Khan Khalid M; Supuran Claudiu T
Organometallic-based antibacterial and antifungal compounds: transition metal complexes of 1,1'-diacetylferrocene-derived thiocarbohydrazone, carbohydrazone, thiosemicarbazone and semicarbazone.
Journal of enzyme inhibition and medicinal chemistry 2005;20(1):81-8.
2005: Hasan Aurangzeb; Khan Khalid M; Sher Mohammed; Maharvi Ghulam M; Nawaz Sarfraz A; Choudhary M I; Atta-ur-Rahman; Supuran Claudiu T
Synthesis and inhibitory potential towards acetylcholinesterase, butyrylcholinesterase and lipoxygenase of some variably substituted chalcones.
Journal of enzyme inhibition and medicinal chemistry 2005;20(1):41-7.
2005: Hisar Olcay; Beydemir Sükrü; Gülçin Ilhami; Küfrevioglu O Irfan; Supuran Claudiu T
Effects of low molecular weight plasma inhibitors of rainbow trout (Oncorhynchus mykiss) on human erythrocyte carbonic anhydrase-II isozyme activity in vitro and rat erythrocytes in vivo.
Journal of enzyme inhibition and medicinal chemistry 2005;20(1):35-9.
2005: Innocenti Alessio; Firnges Michael A; Antel Jochen; Wurl Michael; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.
Bioorganic & medicinal chemistry letters 2005;15(4):1149-54.
2005: Vullo Daniela; Voipio Juha; Innocenti Alessio; Rivera Claudio; Ranki Harri; Scozzafava Andrea; Kaila Kai; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.
Bioorganic & medicinal chemistry letters 2005;15(4):971-6.
2005: Vullo Daniela; Innocenti Alessio; Nishimori Isao; Pastorek Jaromír; Scozzafava Andrea; Pastoreková Silvia; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?
Bioorganic & medicinal chemistry letters 2005;15(4):963-9.
2005: Khadikar Padmakar V; Sharma Vimukta; Karmarkar Sneha; Supuran Claudiu T
Novel use of chemical shift in NMR as molecular descriptor: a first report on modeling carbonic anhydrase inhibitory activity and related parameters.
Bioorganic & medicinal chemistry letters 2005;15(4):931-6.
2005: Khadikar Padmakar V; Sharma Vimukta; Karmarkar Sneha; Supuran Claudiu T
QSAR studies on benzene sulfonamide carbonic anhydrase inhibitors: need of hydrophobic parameter for topological modeling of binding constants of sulfonamides to human CA-II.
Bioorganic & medicinal chemistry letters 2005;15(4):923-30.
2005: Winum Jean-Yves; Pastorekova Silvia; Jakubickova Lydia; Montero Jean-Louis; Scozzafava Andrea; Pastorek Jaromir; Vullo Daniela; Innocenti Alessio; Supuran Claudiu T
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates.
Bioorganic & medicinal chemistry letters 2005;15(3):579-84.
2005: Innocenti Alessio; Vullo Daniela; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.
Bioorganic & medicinal chemistry letters 2005;15(3):567-71.
2005: Turkmen Hasan; Durgun Mustafa; Yilmaztekin Serpil; Emul Mahmut; Innocenti Alessio; Vullo Daniela; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX.
Bioorganic & medicinal chemistry letters 2005;15(2):367-72.
2005: Krungkrai Jerapan; Scozzafava Andrea; Reungprapavut Sutarnthip; Krungkrai Sudaratana R; Rattanajak Roonglawan; Kamchonwongpaisan Sumalee; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of Plasmodium falciparum carbonic anhydrase with aromatic sulfonamides: towards antimalarials with a novel mechanism of action?
Bioorganic & medicinal chemistry 2005;13(2):483-9.
2005: Thakur Mamta; Thakur Abhilash; Khadikar Padmakar V; Supuran Claudiu T
QSAR study on pK(a) vis-à-vis physiological activity of sulfonamides: a dominating role of surface tension (inverse steric parameter).
Bioorganic & medicinal chemistry letters 2005;15(1):203-9.
2005: Barbaro Giuseppe; Scozzafava Andrea; Mastrolorenzo Antonio; Supuran Claudiu T
Highly active antiretroviral therapy: current state of the art, new agents and their pharmacological interactions useful for improving therapeutic outcome.
Current pharmaceutical design 2005;11(14):1805-43.
2004: Rusconi Stefano; Scozzafava Andrea; Mastrolorenzo Antonio; Supuran Claudiu T
New advances in HIV entry inhibitors development.
Current drug targets. Infectious disorders 2004;4(4):339-55.
2004: Zimmerman Sabrina; Innocenti Alessio; Casini Angela; Ferry James G; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.
Bioorganic & medicinal chemistry letters 2004;14(24):6001-6.
2004: Chazalette Celine; Masereel Bernard; Rolin Stéphanie; Thiry Anne; Scozzafava Andrea; Innocenti Alessio; Supuran Claudiu T
Carbonic anhydrase inhibitors. Design of anticonvulsant sulfonamides incorporating indane moieties.
Bioorganic & medicinal chemistry letters 2004;14(23):5781-6.
2004: Cecchi Alessandro; Winum Jean-Yves; Innocenti Alessio; Vullo Daniela; Montero Jean-Louis; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides derived from 4-isothiocyanato-benzolamide.
Bioorganic & medicinal chemistry letters 2004;14(23):5775-80.
2004: Innocenti Alessio; Firnges Michael A; Antel Jochen; Wurl Michael; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.
Bioorganic & medicinal chemistry letters 2004;14(23):5769-73.
2004: Rusconi Stefano; Innocenti Alessio; Vullo Daniela; Mastrolorenzo Antonio; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamoyl phosphate, and the phosphonate antiviral drug foscarnet.
Bioorganic & medicinal chemistry letters 2004;14(23):5763-7.
2004: Morgan Patricio E; Supuran Claudiu T; Casey Joseph R
Carbonic anhydrase inhibitors that directly inhibit anion transport by the human Cl-/HCO3- exchanger, AE1.
Molecular membrane biology 2004;21(6):423-33.
2004: Svastová Eliska; Hulíková Alzbeta; Rafajová Monika; Zat'ovicová Miriam; Gibadulinová Adriana; Casini Angela; Cecchi Alessandro; Scozzafava Andrea; Supuran Claudiu T; Pastorek Jaromír; Pastoreková Silvia
Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH.
FEBS letters 2004;577(3):439-45.
2004: Innocenti Alessio; Antel Jochen; Wurl Michael; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: inhibition of human cytosolic isozyme II and mitochondrial isozyme V with a series of benzene sulfonamide derivatives.
Bioorganic & medicinal chemistry letters 2004;14(22):5703-7.
2004: Jaiswal Mona; Khadikar Padmakar V; Supuran Claudiu T
Topological modeling of lipophilicity, diuretic activity, and carbonic inhibition activity of benzene sulfonamides: a molecular connectivity approach.
Bioorganic & medicinal chemistry letters 2004;14(22):5661-6.
2004: Innocenti Alessio; Lehtonen Jonna M; Parkkila Seppo; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.
Bioorganic & medicinal chemistry letters 2004;14(21):5435-9.
2004: Garaj Vladimir; Puccetti Luca; Fasolis Giuseppe; Winum Jean-Yves; Montero Jean-Louis; Scozzafava Andrea; Vullo Daniela; Innocenti Alessio; Supuran Claudiu T
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties.
Bioorganic & medicinal chemistry letters 2004;14(21):5427-33.
2004: Chohan Zahid H; Pervez Humayun; Rauf A; Khan Khalid M; Supuran Claudiu T
Isatin-derived antibacterial and antifungal compounds and their transition metal complexes.
Journal of enzyme inhibition and medicinal chemistry 2004;19(5):417-23.
2004: Innocenti Alessio; Casini Angela; Alcaro Maria C; Papini Anna M; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: the first on-resin screening of a 4-sulfamoylphenylthiourea library.
Journal of medicinal chemistry 2004;47(21):5224-9.
2004: Innocenti Alessio; Zimmerman Sabrina; Ferry James G; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions.
Bioorganic & medicinal chemistry letters 2004;14(17):4563-7.
2004: Khan Khalid Mohammed; Saify Zafar S; Khan Muhammad Zarrar; Zia-Ullah; Choudhary Iqbal M; Atta-Ur-Rahman; Perveen Shahnaz; Chohan Zahid H; Supuran Claudiu T
Synthesis of coumarin derivatives with cytotoxic, antibacterial and antifungal activity.
Journal of enzyme inhibition and medicinal chemistry 2004;19(4):373-9.
2004: Khan Khalid M; Iqbal Sajid; Lodhi Muhammad A; Maharvi Ghulam M; Perveen Shahnaz; Choudhary M I; Atta-Ur-Rahman; Chohan Zahid H; Supuran Claudiu T
Synthesis and urease enzyme inhibitory effects of some dicoumarols.
Journal of enzyme inhibition and medicinal chemistry 2004;19(4):367-71.
2004: Supuran Claudiu T; Casini Angela; Mastrolorenzo Antonio; Scozzafava Andrea
COX-2 selective inhibitors, carbonic anhydrase inhibition and anticancer properties of sulfonamides belonging to this class of pharmacological agents.
Mini reviews in medicinal chemistry 2004;4(6):625-32.
2004: Agrawal Vijay K; Bano Shahnaz; Supuran Claudiu T; Khadikar Padmakar V
QSAR study on carbonic anhydrase inhibitors: aromatic/heterocyclic sulfonamides containing 8-quinoline-sulfonyl moieties, with topical activity as antiglaucoma agents.
European journal of medicinal chemistry 2004;39(7):593-600.
2004: Lehtonen Jonna M; Parkkila Seppo; Vullo Daniela; Casini Angela; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.
Bioorganic & medicinal chemistry letters 2004;14(14):3757-62.
2004: Tripodi Sergio A; Del Vecchio Maria Teresa; Supuran Claudiu T; Scozzafava Andrea; Gabrielli M Gabriella; Pastorekova Silvia; Rossie Ranieri; Fasolis Giuseppe; Puccetti Luca
Redox state and carbonic anhydrase isozyme IX expression in human renal cell carcinoma: biochemical and morphological investigations.
Journal of enzyme inhibition and medicinal chemistry 2004;19(3):287-91.
2004: Bonnac Laurent; Innocenti Alessio; Winum Jean-Yves; Casini Angela; Montero Jean-Louis; Scozzafava Andrea; Barragan Veronique; Supuran Claudiu T
Carbonic anhydrase inhibitors: aliphatic N-phosphorylated sulfamates--a novel zinc-anchoring group leading to nanomolar inhibitors.
Journal of enzyme inhibition and medicinal chemistry 2004;19(3):275-8.
2004: Supuran Claudiu T; Scozzafava Andrea
Benzolamide is not a membrane-impermeant carbonic anhydrase inhibitor.
Journal of enzyme inhibition and medicinal chemistry 2004;19(3):269-73.
2004: Mahmood-Ul-Hassan; Chohan Zahid H; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: Schiff's bases of aromatic and heterocyclic sulfonamides and their metal complexes.
Journal of enzyme inhibition and medicinal chemistry 2004;19(3):263-7.
2004: Supuran Claudiu T; Clare Brian W
Quantum theoretic QSAR of benzene derivatives: some enzyme inhibitors.
Journal of enzyme inhibition and medicinal chemistry 2004;19(3):237-48.
2004: Pastorekova Silvia; Parkkila Seppo; Pastorek Jaromir; Supuran Claudiu T
Carbonic anhydrases: current state of the art, therapeutic applications and future prospects.
Journal of enzyme inhibition and medicinal chemistry 2004;19(3):199-229.
2004: Innocenti Alessio; Zimmerman Sabrina; Ferry James G; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of the zinc and cobalt gamma-class enzyme from the archaeon Methanosarcina thermophila with anions.
Bioorganic & medicinal chemistry letters 2004;14(12):3327-31.
2004: Jaiswal Mona; Khadikar Padmakar V; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: the first QSAR study on inhibition of tumor-associated isoenzyme IX with aromatic and heterocyclic sulfonamides.
Bioorganic & medicinal chemistry letters 2004;14(12):3283-90.
2004: de Leval Xavier; Ilies Monica; Casini Angela; Dogné Jean-Michel; Scozzafava Andrea; Masini Emanuela; Mincione Francesco; Starnotti Michele; Supuran Claudiu T
Carbonic anhydrase inhibitors: synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity.
Journal of medicinal chemistry 2004;47(11):2796-804.
2004: Ilies Marc A; Masereel Bernard; Rolin Stéphanie; Scozzafava Andrea; Câmpeanu Gheorghe; Cîmpeanu Valentin; Supuran Claudiu T
Carbonic anhydrase inhibitors: aromatic and heterocyclic sulfonamides incorporating adamantyl moieties with strong anticonvulsant activity.
Bioorganic & medicinal chemistry 2004;12(10):2717-26.
2004: Abbate Francesco; Casini Angela; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with a topically acting antiglaucoma sulfonamide.
Bioorganic & medicinal chemistry letters 2004;14(9):2357-61.
2004: Vullo Daniela; Scozzafava Andrea; Pastorekova Silvia; Pastorek Jaromir; Supuran Claudiu T
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with fluorine-containing sulfonamides. The first subnanomolar CA IX inhibitor discovered.
Bioorganic & medicinal chemistry letters 2004;14(9):2351-6.
2004: Jaiswal Mona; Khadikar Padmakar V; Supuran Claudiu T
QSAR study on CA inhibitory activity of disulfonamides: effect of halogen substitution.
Bioorganic & medicinal chemistry 2004;12(9):2477-82.
2004: Chohan Zahid H; Pervez Humayun; Rauf A; Khan Khalid M; Maharvi Ghulam M; Supuran Claudiu T
Antibacterial and antifugal mono- and di-substituted symmetrical and unsymmetrical triazine-derived Schiff-bases and their transition metal complexes.
Journal of enzyme inhibition and medicinal chemistry 2004;19(2):161-8.
2004: Casey Joseph R; Morgan Patricio E; Vullo Daniela; Scozzafava Andrea; Mastrolorenzo Antonio; Supuran Claudiu T
Carbonic anhydrase inhibitors. Design of selective, membrane-impermeant inhibitors targeting the human tumor-associated isozyme IX.
Journal of medicinal chemistry 2004;47(9):2337-47.
2004: Chohan Zahid H; Pervez Humayun; Khan Khalid M; Rauf A; Maharvi Ghulam M; Supuran Claudiu T
Antifungal cobalt(II), copper(II), nickel(II) and zinc(II) complexes of furanyl-,thiophenyl-, pyrrolyl-, salicylyl- and pyridyl-derived cephalexins.
Journal of enzyme inhibition and medicinal chemistry 2004;19(1):85-90.
2004: Chohan Zahid H; Supuran Claudiu T; Scozzafava Andrea
Metalloantibiotics: synthesis and antibacterial activity of cobalt(II), copper(II), nickel(II) and zinc(II) complexes of kefzol.
Journal of enzyme inhibition and medicinal chemistry 2004;19(1):79-84.
2004: Chohan Zahid H; Pervez Humayun; Khan Khalid Mohammed; Rauf A; Supuran Claudiu T
Binding of transition metal ions [cobalt, copper, nickel and zinc] with furanyl-, thiophenyl-, pyrrolyl-, salicylyl- and pyridyl-derived cephalexins as potent antibacterial agents.
Journal of enzyme inhibition and medicinal chemistry 2004;19(1):51-6.
2004: Pastorekova Silvia; Casini Angela; Scozzafava Andrea; Vullo Daniela; Pastorek Jaromir; Supuran Claudiu T
Carbonic anhydrase inhibitors: the first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX.
Bioorganic & medicinal chemistry letters 2004;14(4):869-73.
2004: Vullo Daniela; Franchi Marco; Gallori Enzo; Antel Jochen; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclic sulfonamides.
Journal of medicinal chemistry 2004;47(5):1272-9.
2004: Supuran Claudiu T; Innocenti Alessio; Mastrolorenzo Antonio; Scozzafava Andrea
Antiviral sulfonamide derivatives.
Mini reviews in medicinal chemistry 2004;4(2):189-200.
2004: Thakur Abhilash; Thakur Mamta; Khadikar Padmakar V; Supuran Claudiu T; Sudele Purushottam
QSAR study on benzenesulphonamide carbonic anhydrase inhibitors: topological approach using Balaban index.
Bioorganic & medicinal chemistry 2004;12(4):789-93.
2004: Supuran Claudiu T; Vullo Daniela; Manole Gheorghe; Casini Angela; Scozzafava Andrea
Designing of novel carbonic anhydrase inhibitors and activators.
Current medicinal chemistry. Cardiovascular and hematological agents 2004;2(1):49-68.
2004: Weber Alexander; Casini Angela; Heine Andreas; Kuhn Daniel; Supuran Claudiu T; Scozzafava Andrea; Klebe Gerhard
Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition.
Journal of medicinal chemistry 2004;47(3):550-7.
2004: Abbate Francesco; Coetzee Anita; Casini Angela; Ciattini Samuele; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the antipsychotic drug sulpiride.
Bioorganic & medicinal chemistry letters 2004;14(2):337-41.
2004: Abbate Francesco; Winum Jean-Yves; Potter Barry V L; Casini Angela; Montero Jean-Louis; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with EMATE, a dual inhibitor of carbonic anhydrases and steroid sulfatase.
Bioorganic & medicinal chemistry letters 2004;14(1):231-4.
2004: Winum Jean-Yves; Casini Angela; Mincione Francesco; Starnotti Michele; Montero Jean-Louis; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-alpha-D-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits.
Bioorganic & medicinal chemistry letters 2004;14(1):225-9.
2004: Abbate Francesco; Casini Angela; Owa Takashi; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX.
Bioorganic & medicinal chemistry letters 2004;14(1):217-23.
2004: Lehtonen Jonna; Shen Bairong; Vihinen Mauno; Casini Angela; Scozzafava Andrea; Supuran Claudiu T; Parkkila Anna-Kaisa; Saarnio Juha; Kivelä Antti J; Waheed Abdul; Sly William S; Parkkila Seppo
Characterization of CA XIII, a novel member of the carbonic anhydrase isozyme family.
The Journal of biological chemistry 2004;279(4):2719-27.
2004: Balaban Alexandru T; Basak Subhash C; Beteringhe Adrian; Mills Denise; Supuran Claudiu T
QSAR study using topological indices for inhibition of carbonic anhydrase II by sulfanilamides and Schiff bases.
Molecular diversity 2004;8(4):401-12.
2003: Agrawal Vijay K; Srivastava Shachi; Khadikar Padmakar V; Supuran Claudiu T
Quantitative structure-activity relationship study on sulfanilamide schiff's bases: carbonic anhydrase (CA) inhibitors.
Bioorganic & medicinal chemistry 2003;11(24):5353-62.
2003: Winum Jean-Yves; Vullo Daniela; Casini Angela; Montero Jean-Louis; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: inhibition of transmembrane, tumor-associated isozyme IX, and cytosolic isozymes I and II with aliphatic sulfamates.
Journal of medicinal chemistry 2003;46(25):5471-7.
2003: Vullo Daniela; Franchi Marco; Gallori Enzo; Pastorek Jaromir; Scozzafava Andrea; Pastorekova Silvia; Supuran Claudiu T
Carbonic anhydrase inhibitors. inhibition of cytosolic isozymes I and II and transmembrane, cancer-associated isozyme IX with anions.
Journal of enzyme inhibition and medicinal chemistry 2003;18(5):403-6.
2003: Alvarez Bernardo V; Loiselle Frederick B; Supuran Claudiu T; Schwartz George J; Casey Joseph R
Direct extracellular interaction between carbonic anhydrase IV and the human NBC1 sodium/bicarbonate co-transporter.
Biochemistry 2003;42(42):12321-9.
2003: Mastrolorenzo Antonio; Zuccati Giuliano; Massi Daniela; Gabrielli Maria G; Casini Angela; Scozzafava Andrea; Supuran Claudiu T
Immunohistochemical study of carbonic anhydrase isozymes in human skin.
European journal of dermatology : EJD 2003;13(5):440-4.
2003: Casini Angela; Scozzafava Andrea; Mincione Francesco; Menabuoni Luca; Starnotti Michele; Supuran Claudiu T
Carbonic anhydrase inhibitors: topically acting antiglaucoma sulfonamides incorporating esters and amides of 3- and 4-carboxybenzolamide.
Bioorganic & medicinal chemistry letters 2003;13(17):2867-73.
2003: Franchi Marco; Vullo Daniela; Gallori Enzo; Antel Jochen; Wurl Michael; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: inhibition of human and murine mitochondrial isozymes V with anions.
Bioorganic & medicinal chemistry letters 2003;13(17):2857-61.
2003: Supuran Claudiu T; Casini Angela; Scozzafava Andrea
Protease inhibitors of the sulfonamide type: anticancer, antiinflammatory, and antiviral agents.
Medicinal research reviews 2003;23(5):535-58.
2003: Franchi Marco; Vullo Daniela; Gallori Enzo; Pastorek Jaromir; Russo Antonella; Scozzafava Andrea; Pastorekova Silvia; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, cancer-associated isozyme IX with lipophilic sulfonamides.
Journal of enzyme inhibition and medicinal chemistry 2003;18(4):333-8.
2003: Abbate Francesco; Casini Angela; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the perfluorobenzoyl analogue of methazolamide. Implications for the drug design of fluorinated inhibitors.
Journal of enzyme inhibition and medicinal chemistry 2003;18(4):303-8.
2003: De Simone Giuseppina; Menchise Valeria; Omaggio Salvatore; Pedone Carlo; Scozzafava Andrea; Supuran Claudiu T
Design of weakly basic thrombin inhibitors incorporating novel P1 binding functions: molecular and X-ray crystallographic studies.
Biochemistry 2003;42(30):9013-21.
2003: Casini Angela; Caccia Silvio; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase activators. The selective serotonin reuptake inhibitors fluoxetine, sertraline and citalopram are strong activators of isozymes I and II.
Bioorganic & medicinal chemistry letters 2003;13(16):2765-8.
2003: Casini Angela; Abbate Francesco; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with a bis-sulfonamide-two heads are better than one?
Bioorganic & medicinal chemistry letters 2003;13(16):2759-63.
2003: Chohan Zahid H; Scozzafava Andrea; Supuran Claudiu T
Zinc complexes of benzothiazole-derived Schiff bases with antibacterial activity.
Journal of enzyme inhibition and medicinal chemistry 2003;18(3):259-63.
2003: Santos M Amélia; Marques Sérgio; Gil Marco; Tegoni Matteo; Scozzafava Andrea; Supuran Claudiu T
Protease inhibitors: synthesis of bacterial collagenase and matrix metalloproteinase inhibitors incorporating succinyl hydroxamate and iminodiacetic acid hydroxamate moieties.
Journal of enzyme inhibition and medicinal chemistry 2003;18(3):233-42.
2003: Scozzafava Andrea; Owa Takashi; Mastrolorenzo Antonio; Supuran Claudiu T
Anticancer and antiviral sulfonamides.
Current medicinal chemistry 2003;10(11):925-53.
2003: Winum Jean-Yves; Vullo Daniela; Casini Angela; Montero Jean-Louis; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, tumor-associated isozyme IX with sulfamates including EMATE also acting as steroid sulfatase inhibitors.
Journal of medicinal chemistry 2003;46(11):2197-204.
2003: Ilies Marc A; Vullo Daniela; Pastorek Jaromir; Scozzafava Andrea; Ilies Monica; Caproiu Miron T; Pastorekova Silvia; Supuran Claudiu T
Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives.
Journal of medicinal chemistry 2003;46(11):2187-96.
2003: Scozzafava Andrea; Supuran Claudiu T
Hydroxyurea is a carbonic anhydrase inhibitor.
Bioorganic & medicinal chemistry 2003;11(10):2241-6.
2003: Ilies Monica; Banciu Mircea D; Scozzafava Andrea; Ilies Marc A; Caproiu Miron T; Supuran Claudiu T
Protease inhibitors: synthesis of bacterial collagenase and matrix metalloproteinase inhibitors incorporating arylsulfonylureido and 5-dibenzo-suberenyl/suberyl moieties.
Bioorganic & medicinal chemistry 2003;11(10):2227-39.
2003: Vullo Daniela; Franchi Marco; Gallori Enzo; Pastorek Jaromir; Scozzafava Andrea; Pastorekova Silvia; Supuran Claudiu T
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.
Bioorganic & medicinal chemistry letters 2003;13(6):1005-9.
2003: Casini Angela; Antel Jochen; Abbate Francesco; Scozzafava Andrea; David Samuel; Waldeck Harald; Schäfer Siegfried; Supuran Claudiu T
Carbonic anhydrase inhibitors: SAR and X-ray crystallographic study for the interaction of sugar sulfamates/sulfamides with isozymes I, II and IV.
Bioorganic & medicinal chemistry letters 2003;13(5):841-5.
2003: Casini Angela; Winum Jean-Yves; Montero Jean-Louis; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: inhibition of cytosolic isozymes I and II with sulfamide derivatives.
Bioorganic & medicinal chemistry letters 2003;13(5):837-40.
2003: Supuran Claudiu T; Scozzafava Andrea; Casini Angela
Carbonic anhydrase inhibitors.
Medicinal research reviews 2003;23(2):146-89.
2003: Supuran Claudiu T
Indisulam: an anticancer sulfonamide in clinical development.
Expert opinion on investigational drugs 2003;12(2):283-7.
2002: Supuran Claudiu T
Indisulam. Eisai.
IDrugs : the investigational drugs journal 2002;5(11):1075-9.
2002: Sterling Deborah; Brown Nathan J D; Supuran Claudiu T; Casey Joseph R
The functional and physical relationship between the DRA bicarbonate transporter and carbonic anhydrase II.
American journal of physiology. Cell physiology 2002;283(5):C1522-9.
2002: Casini Angela; Scozzafava Andrea; Mincione Francesco; Menabuoni Luca; Supuran Claudiu T
Carbonic anhydrase inhibitors: synthesis of water soluble sulfonamides incorporating a 4-sulfamoylphenylmethylthiourea scaffold, with potent intraocular pressure lowering properties.
Journal of enzyme inhibition and medicinal chemistry 2002;17(5):333-43.
2002: Casini Angela; Scozzafava Andrea; Supuran Claudiu T
Cysteine-modifying agents: a possible approach for effective anticancer and antiviral drugs.
Environmental health perspectives 2002;110 Suppl 5():801-6.
2002: Maestrelli Francesca; Mura Paola; Casini Angela; Mincione Francesco; Scozzafava Andrea; Supuran Claudiu T
Cyclodextrin complexes of sulfonamide carbonic anhydrase inhibitors as long-lasting topically acting antiglaucoma agents.
Journal of pharmaceutical sciences 2002;91(10):2211-9.
2002: Scozzafava Andrea; Supuran Claudiu T
Protease inhibitors: synthesis of matrix metalloproteinase and bacterial collagenase inhibitors incorporating 5-amino-2-mercapto-1,3,4-thiadiazole zinc binding functions.
Bioorganic & medicinal chemistry letters 2002;12(19):2667-72.
2002: Nielsen Carsten Uhd; Supuran Claudiu T; Scozzafava Andrea; Frokjaer Sven; Steffansen Bente; Brodin Birger
Transport characteristics of L-carnosine and the anticancer derivative 4-toluenesulfonylureido-carnosine in a human epithelial cell line.
Pharmaceutical research 2002;19(9):1337-44.
2002: Chohan Zahid H; Scozzafava Andrea; Supuran Claudiu T
Unsymmetrical 1,1'-disubstituted ferrocenes: synthesis of Co(ii), Cu(ii), Ni(ii) and Zn(ii) chelates of ferrocenyl -1-thiadiazolo-1'-tetrazole, -1-thiadiazolo-1'-triazole and -1-tetrazolo-1'-triazole with antimicrobial properties.
Journal of enzyme inhibition and medicinal chemistry 2002;17(4):261-6.
2002: Abbate Francesco; Supuran Claudiu T; Scozzafava Andrea; Orioli Pierluigi; Stubbs Milton T; Klebe Gerhard
Nonaromatic sulfonamide group as an ideal anchor for potent human carbonic anhydrase inhibitors: role of hydrogen-bonding networks in ligand binding and drug design.
Journal of medicinal chemistry 2002;45(17):3583-7.
2002: Supuran Claudiu T; Scozzafava Andrea; Clare Brian W
Bacterial protease inhibitors.
Medicinal research reviews 2002;22(4):329-72.
2002: Scozzafava Andrea; Casini Angela; Supuran Claudiu T
Targeting cysteine residues of biomolecules: new approaches for the design of antiviral and anticancer drugs.
Current medicinal chemistry 2002;9(12):1167-85.
2002: Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors. Preparation of potent sulfonamides inhibitors incorporating bile acid tails.
Bioorganic & medicinal chemistry letters 2002;12(12):1551-7.
2002: Ferraroni Marta; Tilli Silvia; Briganti Fabrizio; Chegwidden W Richard; Supuran Claudiu T; Wiebauer Karin E; Tashian Richard E; Scozzafava Andrea
Crystal structure of a zinc-activated variant of human carbonic anhydrase I, CA I Michigan 1: evidence for a second zinc binding site involving arginine coordination.
Biochemistry 2002;41(20):6237-44.
2002: Chohan Zahid H; Pervez Humayun; Rauf Abdul; Scozzafava Andrea; Supuran Claudiu T
Antibacterial Co(II), Cu(II), Ni(II) and Zn(II) complexes of thiadiazole derived furanyl, thiophenyl and pyrrolyl Schiff bases.
Journal of enzyme inhibition and medicinal chemistry 2002;17(2):117-22.
2002: Chohan Zahid H; Rau Abdul; Noreen Sobia; Scozzafava Andrea; Supuran Claudiu T
Antibacterial cobalt(II), nickel(II) and zinc(II) complexes of nicotinic acid-derived Schiff-bases.
Journal of enzyme inhibition and medicinal chemistry 2002;17(2):101-6.
2002: Chohan Zahid H; Iqbal Mohammad S; Iqbal Hummara Sadia; Scozzafava Andrea; Supuran Claudiu T
Transition metal acetylsalicylates and their anti-inflammatory activity.
Journal of enzyme inhibition and medicinal chemistry 2002;17(2):87-91.
2002: Scozzafava Andrea; Mastrolorenzo Antonio; Supuran Claudiu T
Non-peptidic chemokine receptors antagonists as emerging anti-HIV agents.
Journal of enzyme inhibition and medicinal chemistry 2002;17(2):69-76.
2002: Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase activators: human isozyme II is strongly activated by oligopeptides incorporating the carboxyterminal sequence of the bicarbonate anion exchanger AE1.
Bioorganic & medicinal chemistry letters 2002;12(8):1177-80.
2002: Scozzafava Andrea; Menabuoni Luca; Mincione Francesco; Supuran Claudiu T
Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.
Journal of medicinal chemistry 2002;45(7):1466-76.
2002: Casini Angela; Mincione Francesco; Vullo Daniela; Menabuoni Luca; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors with strong topical antiglaucoma properties incorporating a 4-(2-aminopyrimidin-4-yl-amino)-benzenesulfonamide scaffold.
Journal of enzyme inhibition and medicinal chemistry 2002;17(1):9-18.
2002: Chohan Zahid H; Farooq M A; Scozzafava Andrea; Supuran Claudiu T
Antibacterial Schiff bases of oxalyl-hydrazine/diamide incorporating pyrrolyl and salicylyl moieties and of their zinc(II) complexes.
Journal of enzyme inhibition and medicinal chemistry 2002;17(1):1-7.
2002: Ilies Monica; Banciu Mircea D; Ilies Marc A; Scozzafava Andrea; Caproiu Miron T; Supuran Claudiu T
Carbonic anhydrase activators: design of high affinity isozymes I, II, and IV activators, incorporating tri-/tetrasubstituted-pyridinium-azole moieties.
Journal of medicinal chemistry 2002;45(2):504-10.
2002: Masereel Bernard; Rolin Stéphanie; Abbate Francesco; Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase inhibitors: anticonvulsant sulfonamides incorporating valproyl and other lipophilic moieties.
Journal of medicinal chemistry 2002;45(2):312-20.
2002: Scozzafava Andrea; Supuran Claudiu T
Carbonic anhydrase activators: high affinity isozymes I, II, and IV activators, incorporating a beta-alanyl-histidine scaffold.
Journal of medicinal chemistry 2002;45(2):284-91.
2002: Chohan Zahid H; Rauf Abdul; Supuran Claudiu T
Antibacterial Co(II) and Ni(II) Complexes of N-(2-Furanylmethylene)-2-Aminothiadiazole and Role of SO(4), NO(3), C(2)O(4) and CH(3)CO(2) anions on Biological Properties.
Metal-based drugs 2002;8(5):287-91.
2002: Chohan Zahid H; Pervez Humayun; Rauf Abdul; Supuran Claudiu T
Antibacterial Role of SO(4), NO(3), C(2)O(4) and CH(3)CO(2) Anions on Cu(II) and Zn(II) Complexes of a Thiadiazole-derived Pyrrolyl Schiff Base.
Metal-based drugs 2002;8(5):263-7.
2001: Ul-Hassan M; Scozzafava A; Chohan Z H; Supuran C T
Carbonic anhydrase inhibitors: metal complexes of a sulfanilamide derived Schiff base and their interaction with isozymes I, II and IV.
Journal of enzyme inhibition 2001;16(6):499-505.
2001: Scozzafava A; Mastrolorenzo A; Supuran C T
Antimycobacterial activity of 3,4-dichlorophenyl-ureas, N,N-diphenyl-ureas and related derivatives.
Journal of enzyme inhibition 2001;16(5):425-32.
2001: Scozzafava A; Saramet I; Banciu M D; Supuran C T
Carbonic anhydrase activity modulators: synthesis of inhibitors and activators incorporating 2-substituted-thiazol-4-yl-methyl scaffolds.
Journal of enzyme inhibition 2001;16(4):351-8.
2001: Mincione F; Starnotti M; Menabuoni L; Scozzafava A; Casini A; Supuran C T
Carbonic anhydrase inhibitors: 4-sulfamoyl-benzenecarboxamides and 4-chloro-3-sulfamoyl-benzenecarboxamides with strong topical antiglaucoma properties.
Bioorganic & medicinal chemistry letters 2001;11(13):1787-91.
2001: Scozzafava A; Mastrolorenzo A; Supuran C T
Antimycobacterial activity of 9-sulfonylated/sulfenylated-6-mercaptopurine derivatives.
Bioorganic & medicinal chemistry letters 2001;11(13):1675-8.
2001: Clare B W; Scozzafava A; Supuran C T
Protease inhibitors: synthesis of a series of bacterial collagenase inhibitors of the sulfonyl amino acyl hydroxamate type.
Journal of medicinal chemistry 2001;44(13):2253-8.
2001: Supuran C T; Briganti F; Tilli S; Chegwidden W R; Scozzafava A
Carbonic anhydrase inhibitors: sulfonamides as antitumor agents?
Bioorganic & medicinal chemistry 2001;9(3):703-14.
2001: Scozzafava A; Menabuoni L; Mincione F; Mincione G; Supuran C T
Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating dtpa tails and of their zinc complexes with powerful topical antiglaucoma properties.
Bioorganic & medicinal chemistry letters 2001;11(4):575-82.
2001: Scozzafava A; Mastrolorenzo A; Supuran C T
Arylsulfonyl-N,N-dialkyl-dithiocarbamates as tumor cell growth inhibitors: novel agents targeting beta-tubulin?
Journal of enzyme inhibition 2001;16(1):55-63.
2001: Clare B W; Scozzafava A; Supuran C T
Protease inhibitors, part 13: Specific, weakly basic thrombin inhibitors incorporating sulfonyl dicyandiamide moieties in their structure.
Journal of enzyme inhibition 2001;16(1):1-13.
2001: Chohan Z H; Farooq M A; Supuran C T
Copper (II) Acylhydrazinates. Their Synthesis and Characterization.
Metal-based drugs 2001;8(3):171-7.
2001: Chohan Z H; Munawar A; Supuran C T
Transition Metal Ion Complexes of Schiff-bases. Synthesis, Characterization and Antibacterial Properties.
Metal-based drugs 2001;8(3):137-43.
2001: Chohan Z H; Jaffery M F; Supuran C T
Antibacterial Co(II), Cu(II), Ni(II) and Zn(II) Complexes of Thiadiazoles Schiff Bases.
Metal-based drugs 2001;8(2):95-101.
2001: Scozzafava A; Mincione F; Menabuoni L; Supuran C T
Carbonic anhydrase inhibitors: topically acting antiglaucoma sulfonamides incorporating phthaloyl and phthalimido moieties.
Drug design and discovery 2001;17(4):337-48.
2001: Supuran C T; Clare B W
Orbital symmetry in QSAR: some Schiff's base inhibitors of carbonic anhydrase.
SAR and QSAR in environmental research 2001;12(1-2):17-29.
2001: Casini A; Mincione F; Ilies M A; Menabuoni L; Scozzafava A; Supuran C T
Carbonic anhydrase inhibitors: synthesis and inhibition against isozymes I, II and IV of topically acting antiglaucoma sulfonamides incorporating cis-5-norbornene-endo-3-carboxy-2-carboxamido moieties.
Journal of enzyme inhibition 2001;16(2):113-23.
2000: Casini A; Scozzafava A; Mincione F; Menabuoni L; Ilies M A; Supuran C T
Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects.
Journal of medicinal chemistry 2000;43(25):4884-92.
2000: Scozzafava A; Menabuoni L; Mincione F; Briganti F; Mincione G; Supuran C T
Carbonic anhydrase inhibitors: perfluoroalkyl/aryl-substituted derivatives of aromatic/heterocyclic sulfonamides as topical intraocular pressure-lowering agents with prolonged duration of action.
Journal of medicinal chemistry 2000;43(23):4542-51.
2000: Scozzafava A; Supuran C T
Carbonic anhydrase and matrix metalloproteinase inhibitors: sulfonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of CA isozymes I, II, and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes.
Journal of medicinal chemistry 2000;43(20):3677-87.
2000: Ilies M; Supuran C T; Scozzafava A; Casini A; Mincione F; Menabuoni L; Caproiu M T; Maganu M; Banciu M D
Carbonic anhydrase inhibitors: sulfonamides incorporating furan-, thiophene- and pyrrole-carboxamido groups possess strong topical intraocular pressure lowering properties as aqueous suspensions.
Bioorganic & medicinal chemistry 2000;8(8):2145-55.
2000: Scozzafava A; Mastrolorenzo A; Supuran C T
Arylsulfonyl-N,N-diethyl-dithiocarbamates: a novel class of antitumor agents.
Bioorganic & medicinal chemistry letters 2000;10(16):1887-91.
2000: Scozzafava A; Ilies M A; Manole G; Supuran C T
Protease inhibitors. Part 12. Synthesis of potent matrix metalloproteinase and bacterial collagenase inhibitors incorporating sulfonylated N-4-nitrobenzyl-beta-alanine hydroxamate moieties.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2000;11(1):69-79.
2000: Scozzafava A; Supuran C T
Protease inhibitors: synthesis of potent bacterial collagenase and matrix metalloproteinase inhibitors incorporating N-4-nitrobenzylsulfonylglycine hydroxamate moieties.
Journal of medicinal chemistry 2000;43(9):1858-65.
2000: Supuran C T; Scozzafava A; Briganti F; Clare B W
Protease inhibitors: synthesis and QSAR study of novel classes of nonbasic thrombin inhibitors incorporating sulfonylguanidine and O-methylsulfonylisourea moieties at P1.
Journal of medicinal chemistry 2000;43(9):1793-806.
2000: Supuran C T; Briganti F; Menabuoni L; Mincione G; Mincione F; Scozzafava A
Carbonic anhydrase inhibitors - part 78(#). Synthesis of water-soluble sulfonamides incorporating beta-alanyl moieties, possessing long lasting-intraocular pressure lowering properties via the topical route.
European journal of medicinal chemistry 2000;35(3):309-21.
2000: Scozzafava A; Supuran C T
Protease inhibitors - part 5. Alkyl/arylsulfonyl- and arylsulfonylureido-/arylureido- glycine hydroxamate inhibitors of Clostridium histolyticum collagenase.
European journal of medicinal chemistry 2000;35(3):299-307.
2000: Scozzafava A; Supuran C T
Protease inhibitors: synthesis of clostridium histolyticum collagenase inhibitors incorporating sulfonyl-L-alanine hydroxamate moieties.
Bioorganic & medicinal chemistry letters 2000;10(5):499-502.
2000: Scozzafava A; Supuran C T
Protease inhibitors. Part 8: synthesis of potent Clostridium histolyticum collagenase inhibitors incorporating sulfonylated L-alanine hydroxamate moieties.
Bioorganic & medicinal chemistry 2000;8(3):637-45.
2000: Supuran C T; Scozzafava A
Protease inhibitors. Part 7. Inhibition of Clostridium histolyticum collagenase with sulfonylated derivatives of L-valine hydroxamate.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2000;10(1):67-76.
2000: Scozzafava A; Supuran C T
Carbonic anhydrase activators. Part 24. High affinity isozymes I, II and IV activators, derivatives of 4-(4-chlorophenylsulfonylureido-amino acyl)ethyl-1H-imidazole.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2000;10(1):29-41.
2000: Scozzafava A; Supuran C T
Carbonic anhydrase activators - part 21. Novel activators of isozymes I, II and IV incorporating carboxamido and ureido histamine moieties.
European journal of medicinal chemistry 2000;35(1):31-9.
2000: Scozzafava A; Briganti F; Ilies M A; Supuran C T
Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes.
Journal of medicinal chemistry 2000;43(2):292-300.
2000: Ilies M A; Supuran C T; Scozzafava A
Carbonic anhydrase inhibitors. Part 91. Metal complexes of heterocyclic sulfonamides as potential pharmacological agents in the treatment of gastric Acid secretion imbalances.
Metal-based drugs 2000;7(2):57-62.
2000: Supuran C T; Scozzafava A
Activation of carbonic anhydrase isozymes.
EXS 2000;(90):197-219.
2000: Supuran C T; Scozzafava A
Carbonic anhydrase inhibitors: aromatic sulfonamides and disulfonamides act as efficient tumor growth inhibitors.
Journal of enzyme inhibition 2000;15(6):597-610.
2000: Scozzafava A; Banciu M D; Popescu A; Supuran C T
Carbonic anhydrase inhibitors: synthesis of Schiff bases of hydroxybenzaldehydes with aromatic sulfonamides and their reactions with arylsulfonyl isocyanates.
Journal of enzyme inhibition 2000;15(6):533-46.
2000: Supuran C T; Scozzafava A
Carbonic anhydrase activators: synthesis of high affinity isozymes I, II and IV activators, derivatives of 4-(arylsulfonylureido-amino acyl)ethyl-1H-imidazole.
Journal of enzyme inhibition 2000;15(5):471-86.
2000: Scozzafava A; Banciu M D; Popescu A; Supuran C T
Carbonic anhydrase inhibitors: inhibition of isozymes I, II and IV by sulfamide and sulfamic acid derivatives.
Journal of enzyme inhibition 2000;15(5):443-53.
2000: Supuran C T; Scozzafava A; Ilies M A; Briganti F
Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating 2,4,6-trisubstituted-pyridinium-ethylcarboxamido moieties possessing membrane-impermeability and in vivo selectivity for the membrane-bound (CA IV) versus the cytosolic (CA I and CA II) isozymes.
Journal of enzyme inhibition 2000;15(4):381-401.
2000: Supuran C T; Briganti F; Scozzafava A; Ilies M A
Protease inhibitors: Part 4. Synthesis of weakly basic thrombin inhibitors incorporating pyridinium-sulfanilylaminoguanidine moieties.
Journal of enzyme inhibition 2000;15(4):335-56.
2000: Briganti F; Tilli S; Mincione G; Mincione F; Menabuoni L; Supuran C T
Carbonic anhydrase inhibitors. metal complexes of 5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide with topical intraocular pressure lowering properties: the influence of metal ions upon the pharmacological activity.
Journal of enzyme inhibition 2000;15(2):185-200.
2000: Scozzafava A; Iorga B; Supuran C T
Carbonic anhydrase activators: synthesis of high affinity isozymes I, II and IV activators, derivatives of 4-(4-tosylureido-amino acyl)ethyl-1H-imidazole (histamine derivatives).
Journal of enzyme inhibition 2000;15(2):139-61.
2000: Supuran C T; Briganti F; Mincione G; Scozzafava A
Protease inhibitors: Synthesis of L-alanine hydroxamate sulfonylated derivatives as inhibitors of clostridium histolyticum collagenase.
Journal of enzyme inhibition 2000;15(2):111-28.
2000: Barboiu M; Supuran C T; Menabuoni L; Scozzafava A; Mincione F; Briganti F; Mincione G
Carbonic anhydrase inhibitors. Synthesis of topically effective intraocular pressure lowering agents derived from 5-(omega-aminoalkylcarboxamido)-1,3,4-thiadiazole-2-sulfonamide.
Journal of enzyme inhibition 2000;15(1):23-46.
2000: Clare B W; Scozzafava A; Briganti F; Iorga B; Supuran C T
Protease inhibitors. Part 2. Weakly basic thrombin inhibitors incorporating sulfonyl-aminoguanidine moieties as S1 anchoring groups: synthesis and structure-activity correlations.
Journal of enzyme inhibition 2000;15(3):235-64.
1999: Supuran C T; Scozzafava A
Carbonic anhydrase activators: amino acyl/dipeptidyl histamine derivatives bind with high affinity to isozymes I, II and IV and act as efficient activators.
Bioorganic & medicinal chemistry 1999;7(12):2915-23.
1999: Mincione G; Menabuoni L; Briganti F; Mincione F; Scozzafava A; Supuran C T
Carbonic anhydrase inhibitors. Part 79. Synthesis of topically acting sulfonamides incorporating GABA moieties in their molecule, with long-lasting intraocular pressure-lowering properties.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 1999;9(2):185-99.
1999: Borras J; Scozzafava A; Menabuoni L; Mincione F; Briganti F; Mincione G; Supuran C T
Carbonic anhydrase inhibitors: synthesis of water-soluble, topically effective intraocular pressure lowering aromatic/heterocyclic sulfonamides containing 8-quinoline-sulfonyl moieties: is the tail more important than the ring?
Bioorganic & medicinal chemistry 1999;7(11):2397-406.
1999: Scozzafava A; Briganti F; Mincione G; Menabuoni L; Mincione F; Supuran C T
Carbonic anhydrase inhibitors: synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route.
Journal of medicinal chemistry 1999;42(18):3690-700.
1999: Supuran C T; Scozzafava A; Menabuoni L; Mincione F; Briganti F; Mincione G
Carbonic anhydrase inhibitors. Part 71. Synthesis and ocular pharmacology of a new class of water-soluble, topically effective intraocular pressure lowering sulfonamides incorporating picolinoyl moieties.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 1999;8(4):317-28.
1999: Supuran C T; Scozzafava A; Mincione F; Menabuoni L; Briganti F; Mincione G; Jitianu M
Carbonic anhydrase inhibitors. Part 60(#). The topical intraocular pressure-lowering properties of metal complexes of a heterocyclic sulfonamide: influence of the metal ion upon biological activity.
European journal of medicinal chemistry 1999;34(7-8):585-95.
1999: Briganti F; Scozzafava A; Supuran C T
Novel carbonic anhydrase isozymes I, II and IV activators incorporating sulfonyl-histamino moieties.
Bioorganic & medicinal chemistry letters 1999;9(14):2043-8.
1999: Scozzafava A; Menabuoni L; Mincione F; Briganti F; Mincione G; Supuran C T
Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?
Journal of medicinal chemistry 1999;42(14):2641-50.
1999: Menabuoni L; Scozzafava A; Mincione F; Briganti F; Mincione G; Supuran C T
Carbonic anhydrase inhibitors. Water-soluble, topically effective intraocular pressure lowering agents derived from isonicotinic acid and aromatic/heterocyclic sulfonamides: is the tail more important than the ring?
Journal of enzyme inhibition 1999;14(6):457-74.
1999: Popescu A; Simion A; Scozzafava A; Briganti F; Supuran C T
Carbonic anhydrase inhibitors. Schiff bases of some aromatic sulfonamides and their metal complexes: towards more selective inhibitors of carbonic anhydrase isozyme IV.
Journal of enzyme inhibition 1999;14(6):407-23.
1999: Scozzafava A; Supuran C T
Carbonic anhydrase inhibitors. Arylsulfonylureido- and arylureido-substituted aromatic and heterocyclic sulfonamides: towards selective inhibitors of carbonic anhydrase isozyme I.
Journal of enzyme inhibition 1999;14(5):343-63.
1999: Supuran C T; Scozzafava A; Briganti F
Carbonic anhydrase inhibitors: N-cyanosulfonamides, a new class of high affinity isozyme II and IV inhibitors.
Journal of enzyme inhibition 1999;14(4):289-306.
1998: Scozzafava A; Supuran C T
Carbonic anhydrase inhibitors: novel compounds containing S-NH moieties: sulfenamido-sulfonamides, sulfenimido-sulfonamides and their interaction with isozymes I, II and IV.
Journal of enzyme inhibition 1998;13(6):419-42.
1998: Supuran C T; Scozzafava A; Briganti F; Loloiu G; Maior O
Sulfonylamido derivatives of 2-aminophenoxathiin-10,10-dioxide and related compounds possess antifungal action due to the possible inhibition of lanosterol-14-alpha-demethylase.
Journal of enzyme inhibition 1998;13(4):291-310.
1998: Mincione F; Menabuoni L; Briganti F; Mincione G; Scozzafava A; Supuran C T
Carbonic anhydrase inhibitors: inhibition of isozymes I, II and IV with N-hydroxysulfonamides--a novel class of intraocular pressure lowering agents.
Journal of enzyme inhibition 1998;13(4):267-84.
1998: Supuran C T; Scozzafava A; Saramet I; Banciu M D
Carbonic anhydrase inhibitors: inhibition of isozymes I, II and IV with heterocyclic mercaptans, sulfenamides, sulfonamides and their metal complexes.
Journal of enzyme inhibition 1998;13(3):177-94.
1998: Scozzafava A; Supuran C T
Carbonic anhydrase inhibitors: ureido and thioureido derivatives of aromatic sulfonamides possessing increased affinities for isozyme I. A novel route to 2,5-disubstituted-1,3,4-thiadiazoles via thioureas, and their interaction with isozymes I, II and IV.
Journal of enzyme inhibition 1998;13(2):103-23.
1998: Scozzafava A; Nicolae A; Maior O; Briganti F; Supuran C T
The antifungal activity of 2,2'-diamino-4,4'-dithiazole derivatives is due to the possible inhibition of lanosterol-14-alpha-demethylase.
Journal of enzyme inhibition 1998;14(1):49-68.
1997: Supuran C T; Briganti F; Scozzafava A
Sulfenamido-sulfonamides as inhibitors of carbonic anhydrase isozymes I, II and IV.
Journal of enzyme inhibition 1997;12(3):175-90.
1997: Briganti F; Mangani S; Orioli P; Scozzafava A; Vernaglione G; Supuran C T
Carbonic anhydrase activators: X-ray crystallographic and spectroscopic investigations for the interaction of isozymes I and II with histamine.
Biochemistry 1997;36(34):10384-92.
1997: Supuran C T; Scozzafava A
Novel aromatic/heterocyclic sulfonamides and their metal complexes as inhibitors of carbonic anhydrase isozymes I, II and IV.
Journal of enzyme inhibition 1997;12(1):37-51.
1997: Supuran C T; Conroy C W; Maren T H
Is cyanate a carbonic anhydrase substrate?
Proteins 1997;27(2):272-8.
1996: Sumalan S L; Casanova J; Alzuet G; Borrás J; Castiñeiras A; Supuran C T
Synthesis and characterization of metal(II)-8-quinolinsulfonamidato (sa-) complexes (M = Co, Ni, Cu, and Zn). Crystal structure of [Zn(sa)2(NH3)]NH3 complex. Carbonic anhydrase inhibitory properties.
Journal of inorganic biochemistry 1996;62(1):31-9.
1996: Borràs J; Casanova J; Cristea T; Gheorghe A; Scozzafava A; Supuran C T; Tudor V
Complexes With Biologically Active Ligands. Part 6 Ni(II) Coordination Compounds of Hydrazine and Heterocyclic Sulfonamides as Inhibitors of the Zinc Enzyme Carbonic Anhydrase.
Metal-based drugs 1996;3(3):143-8.
1996: Supuran C T
Complexes with biologically active ligands. Part 4. Coordination compounds of chlorothiazide with transition metal ions behave as strong carbonic anhydrase inhibitors.
Metal-based drugs 1996;3(2):79-83.
1996: Supuran C T
Complexes With Biologically Active Ligands. Part 2. Preparation of Copper(II) Complexes of Positively-Charged Derivatives of Aminoglutethimide.
Metal-based drugs 1996;3(2):57-62.
1996: Supuran C T
Complexes with biologically active ligands. Part 1. Synthesis of coordination compounds of diazoxide with transition- and main-group cations.
Metal-based drugs 1996;3(1):25-30.

Sign-in to see more

Sign-in free and Explore the Exciting World of BiomedExperts:

NetworkView

Claudiu Supuran

Research Profile (preview)

Chemicals & Drugs

Concepts & Ideas

Genes & Molecular Sequences

Occupations

Procedures

Anatomy

Network (preview)

Publications

Sign in free and see...

Visualized networks:

GeoTargeted Searches:

Research Profiles:

Geonetwork of Claudiu Supuran (preview)

All Publications