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Young-Joon Surh

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Mee-Hyun Lee; Sung-Young Lee; Si Jun Park; Young-Joon Surh; Hua Xie; Zunnan Huang; Dong Joon Kim; Jae Young Kim; Myoung Ok Kim; Sung-Hyun Kim; Joydeb Kumar Kundu; Ann M Bode; Zigang Dong
Direct Targeting of MEK1/2 and RSK2 by Silybin Induces Cell-Cycle Arrest and Inhibits Melanoma Cell Growth.
Mee-Hyun Lee; Sung-Young Lee; Young-Joon Surh; Ann M Bode; Yong-Yeon Cho; Bu Young Choi; Zunnan Huang; Dong Joon Kim; Myoung Ok Kim; Joydeb Kumar Kundu; Zigang Dong
Tumor suppressor p16INK4a inhibits cancer cell growth by downregulating eEF1A2 through a direct interaction.
Ha-Na Lee; Hye-Kyung Na; Young-Joon Surh
Resolution of inflammation as a novel chemopreventive strategy.

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2013: Mee-Hyun Lee; Sung-Young Lee; Si Jun Park; Young-Joon Surh; Hua Xie; Zunnan Huang; Dong Joon Kim; Jae Young Kim; Myoung Ok Kim; Sung-Hyun Kim; Joydeb Kumar Kundu; Ann M Bode; Zigang Dong
Direct Targeting of MEK1/2 and RSK2 by Silybin Induces Cell-Cycle Arrest and Inhibits Melanoma Cell Growth.
Cancer prevention research (Philadelphia, Pa.) 2013;6(5):455-65.
2013: Mee-Hyun Lee; Sung-Young Lee; Young-Joon Surh; Ann M Bode; Yong-Yeon Cho; Bu Young Choi; Zunnan Huang; Dong Joon Kim; Myoung Ok Kim; Joydeb Kumar Kundu; Zigang Dong
Tumor suppressor p16INK4a inhibits cancer cell growth by downregulating eEF1A2 through a direct interaction.
Journal of cell science 2013;126(Pt 8):1744-52.
2013: Ha-Na Lee; Hye-Kyung Na; Young-Joon Surh
Resolution of inflammation as a novel chemopreventive strategy.
Seminars in immunopathology 2013;35(2):151-61.
2013: Inas Almazari; Young-Joon Surh
Cancer chemopreventive and therapeutic potential of guggulsterone.
Topics in current chemistry 2013;329():35-60.
2012: Ha-Na Lee; Young-Joon Surh
Therapeutic potential of resolvins in the prevention and treatment of inflammatory disorders.
Biochemical pharmacology 2012;84(10):1340-50.
2012: Hye-Kyung Na; Jong-Min Park; Min-Ah Choi; Do-Hee Kim; Eun-Hee Kim; Young-Joon Surh
Diallyl trisulfide induces apoptosis in human breast cancer cells through ROS-mediated activation of JNK and AP-1.
Biochemical pharmacology 2012;84(10):1241-50.
2012: Na-Young Song; Young-Joon Surh
Janus-faced role of SIRT1 in tumorigenesis.
Annals of the New York Academy of Sciences 2012;1271():10-9.
2012: Sin-Aye Park; Hye-Kyung Na; Young-Joon Surh
Resveratrol suppresses 4-hydroxyestradiol-induced transformation of human breast epithelial cells by blocking IκB kinaseβ-NF-κB signalling.
Free radical research 2012;46(8):1051-7.
2012: Joydeb Kumar Kundu; Young-Joon Surh
Emerging avenues linking inflammation and cancer.
Free radical biology & medicine 2012;52(9):2013-37.
2012: Jun-Wan Shin; Joydeb Kumar Kundu; Young-Joon Surh
Phloretin inhibits phorbol ester-induced tumor promotion and expression of cyclooxygenase-2 in mouse skin: extracellular signal-regulated kinase and nuclear factor-κB as potential targets.
Journal of medicinal food 2012;15(3):253-7.
2012: Inas Almazari; Young-Nam Cha; Hye-Kyung Na; Jong-Min Park; Sin-Aye Park; Jin-Young Suh; Young-Joon Surh
Guggulsterone induces heme oxygenase-1 expression through activation of Nrf2 in human mammary epithelial cells: PTEN as a putative target.
Carcinogenesis 2012;33(2):368-76.
2011: Hye-Kyung Na; Jong-Min Park; Hee Geum Lee; Ha-Na Lee; Seung-Jae Myung; Young-Joon Surh
15-Hydroxyprostaglandin dehydrogenase as a novel molecular target for cancer chemoprevention and therapy.
Biochemical pharmacology 2011;82(10):1352-60.
2011: Young-Joon Surh; In-Soo Yoon; Wonki Kim; Ha-Na Lee; Hye-Kyung Na; Jong-Min Park; Dae-Duk Kim
15-Deoxy-Δ¹²,¹⁴-prostaglandin J₂, an electrophilic lipid mediator of anti-inflammatory and pro-resolving signaling.
Biochemical pharmacology 2011;82(10):1335-51.
2011: Na-Young Song; Young-Ger Suh; Do-Hee Kim; Eun-Hee Kim; Nam-Jung Kim; Hye-Kyung Na; Young-Joon Surh
Multidrug resistance-associated protein 1 mediates 15-deoxy-Δ(12,14)-prostaglandin J2-induced expression of glutamate cysteine ligase expression via Nrf2 signaling in human breast cancer cells.
Chemical research in toxicology 2011;24(8):1231-41.
2011: Han-Cheon Um; Jung-Hee Jang; Do-Hee Kim; Chan Lee; Young-Joon Surh
Nitric oxide activates Nrf2 through S-nitrosylation of Keap1 in PC12 cells.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2011;25(2):161-8.
2011: Young-Joon Surh
Xenohormesis mechanisms underlying chemopreventive effects of some dietary phytochemicals.
Annals of the New York Academy of Sciences 2011;1229():1-6.
2011: Young-Joon Surh; Hye-Kyung Na; Roderick H Dashwood; Li Li Ji
Introduction to Nutrition and physical activity in aging, obesity, and cancer.
Annals of the New York Academy of Sciences 2011;1229():vii-viii.
2011: Seung-Ju Cho; Young-Jong Kim; Young-Joon Surh; B Moon Kim; Seung-Ki Lee
Ibulocydine is a novel prodrug Cdk inhibitor that effectively induces apoptosis in hepatocellular carcinoma cells.
The Journal of biological chemistry 2011;286(22):19662-71.
2011: Jun-Wan Shin; Kohta Ohnishi; Akira Murakami; Jeong-Sang Lee; Joydip Kundu ; Hye-Kyung Na; Hajime Ohigashi; Young-Joon Surh
Zerumbone induces heme oxygenase-1 expression in mouse skin and cultured murine epidermal cells through activation of Nrf2.
Cancer prevention research (Philadelphia, Pa.) 2011;4(6):860-70.
2011: Eun-Jin Chang; Joydip Kundu ; Lijia Liu; Jun-Wan Shin; Young-Joon Surh
Ultraviolet B radiation activates NF-κB and induces iNOS expression in HR-1 hairless mouse skin: role of IκB kinase-β.
Molecular carcinogenesis 2011;50(4):310-7.
2011: Do-Hee Kim; Joydip Kundu ; Young-Joon Surh
Redox modulation of p53: mechanisms and functional significance.
Molecular carcinogenesis 2011;50(4):222-34.
2011: Mostafizur Rahman; Jun-Wan Shin; Joydip Kundu ; Hye-Kyung Na; Young-Joon Surh
Docosahexaenoic acid inhibits UVB-induced activation of NF-κB and expression of COX-2 and NOX-4 in HR-1 hairless mouse skin by blocking MSK1 signaling.
PloS one 2011;6(11):e28065.
2011: Ole Vang; Thomas Walle; Nihal Ahmad; Clifton A Baile; Joseph A Baur; Karen Brown; Anna Csiszar; Dipak K Das; Dominique Delmas; Carmem Gottfried; Hung-Yun Lin; Qing-Yong Ma; Partha Mukhopadhyay; Namasivayam Nalini; John M Pezzuto; Tristan Richard; Yogeshwer Shukla; Young-Joon Surh; Thomas Szekeres; Tomasz Szkudelski; Joseph M Wu
What is new for an old molecule? Systematic review and recommendations on the use of resveratrol.
PloS one 2011;6(6):e19881.
2010: Min-Jung Kim; Do-Hee Kim; Hye-Kyung Na; Young-Joon Surh
TNF-α induces expression of urokinase-type plasminogen activator and β-catenin activation through generation of ROS in human breast epithelial cells.
Biochemical pharmacology 2010;80(12):2092-100.
2010: Won-Hee Lee; Joon-Seok Choi; Mi-Ran Byun; Kyo-Tan Koo; Soona Shin; Seung-Ki Lee; Young-Joon Surh
Functional inactivation of triosephosphate isomerase through phosphorylation during etoposide-induced apoptosis in HeLa cells: potential role of Cdk2.
Toxicology 2010;278(2):224-8.
2010: Hee Geum Lee; Mei-Hua Li; Eun-Joo Joung; Hye-Kyung Na; Young-Nam Cha; Young-Joon Surh
Nrf2-Mediated heme oxygenase-1 upregulation as adaptive survival response to glucose deprivation-induced apoptosis in HepG2 cells.
Antioxidants & redox signaling 2010;13(11):1639-48.
2010: So-Hyun Park; Jung-Hee Jang; Chu-Yue Chen; Hye-Kyung Na; Young-Joon Surh
A formulated red ginseng extract rescues PC12 cells from PCB-induced oxidative cell death through Nrf2-mediated upregulation of heme oxygenase-1 and glutamate cysteine ligase.
Toxicology 2010;278(1):131-9.
2010: Young-Joon Surh; Ann M Bode; Zigang Dong
Breaking the NF-κB and STAT3 alliance inhibits inflammation and pancreatic tumorigenesis.
Cancer prevention research (Philadelphia, Pa.) 2010;3(11):1379-81.
2010: Hyun-Hee Lee; Sin-Aye Park; Inas Almazari; Eun-Hee Kim; Hye-Kyung Na; Young-Joon Surh
Piceatannol induces heme oxygenase-1 expression in human mammary epithelial cells through activation of ARE-driven Nrf2 signaling.
Archives of biochemistry and biophysics 2010;501(1):142-50.
2010: Jiyoung Kim; Young-Nam Cha; Young-Joon Surh
A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders.
Mutation research 2010;690(1-2):12-23.
2010: Pil-Soon Son; Sin-Aye Park; Hye-Kyung Na; Dae-Myung Jue; Sanghee Kim; Young-Joon Surh
Piceatannol, a catechol-type polyphenol, inhibits phorbol ester-induced NF-{kappa}B activation and cyclooxygenase-2 expression in human breast epithelial cells: cysteine 179 of IKK{beta} as a potential target.
Carcinogenesis 2010;31(8):1442-9.
2010: Won-Hee Lee; Joon-Seok Choi; Hyun Young Kim; Jeong Hill Park; Byoung Duck Park; Seung Ju Cho; Seung-Ki Lee; Young-Joon Surh
Potentiation of etoposide-induced apoptosis in HeLa cells by co-treatment with KG-135, a quality-controlled standardized ginsenoside formulation.
Cancer letters 2010;294(1):74-81.
2010: Yun-Kyoung Lee; Jin-Taek Hwang; Dae Young Kwon; Young-Joon Surh; Ock Jin Park
Induction of apoptosis by quercetin is mediated through AMPKalpha1/ASK1/p38 pathway.
Cancer letters 2010;292(2):228-36.
2010: Norleena P Gullett; A R M Ruhul Amin; Soley Bayraktar; John M Pezzuto; Dong M Shin; Fadlo R Khuri; Bharat B Aggarwal; Young-Joon Surh; Omer Kucuk
Cancer prevention with natural compounds.
Seminars in oncology 2010;37(3):258-81.
2010: Joydip Kundu ; Young-Joon Surh
Nrf2-Keap1 signaling as a potential target for chemoprevention of inflammation-associated carcinogenesis.
Pharmaceutical research 2010;27(6):999-1013.
2010: Yun-Kyoung Lee; Song Yi Park; Young-Min Kim; Dong-Chool Kim; Won Sup Lee; Young-Joon Surh; Ock Jin Park
Suppression of mTOR via Akt-dependent and -independent mechanisms in selenium-treated colon cancer cells: involvement of AMPKalpha1.
Carcinogenesis 2010;31(6):1092-9.
2010: Dong-Hyun Kim; E-H Kim; Hye-Kyung Na; Y Sun; Young-Joon Surh
15-Deoxy-Delta(12,14)-prostaglandin J(2) stabilizes, but functionally inactivates p53 by binding to the cysteine 277 residue.
Oncogene 2010;29(17):2560-76.
2010: Ki Mo Kim; Dong Ho Jung; Dae Sik Jang; Young Sook Kim; Jong Min Kim; Ha-Na Kim; Young-Joon Surh; Jin Sook Kim
Puerarin suppresses AGEs-induced inflammation in mouse mesangial cells: a possible pathway through the induction of heme oxygenase-1 expression.
Toxicology and applied pharmacology 2010;244(2):106-13.
2010: Sangeeta Shrotriya; Joydeb Kumar Kundu; Hye-Kyung Na; Young-Joon Surh
Diallyl trisulfide inhibits phorbol ester-induced tumor promotion, activation of AP-1, and expression of COX-2 in mouse skin by blocking JNK and Akt signaling.
Cancer research 2010;70(5):1932-40.
2010: Ki Cheon Kim; Kyoung Ah Kang; Rui Zhang; Mei Jing Piao; Gi Young Kim; Mi Young Kang; Su-Jae Lee; Nam Ho Lee; Young-Joon Surh; Jin Won Hyun
Up-regulation of Nrf2-mediated heme oxygenase-1 expression by eckol, a phlorotannin compound, through activation of Erk and PI3K/Akt.
The international journal of biochemistry & cell biology 2010;42(2):297-305.
2010: Kyu Han Kim; Jae-Yeon Jeong; Young-Joon Surh; Kyu-Won Kim
Expression of stress-response ATF3 is mediated by Nrf2 in astrocytes.
Nucleic acids research 2010;38(1):48-59.
2009: MH Lee; Bo Youl Choi; Joydip Kundu ; Young Kee Shin; Hye-Kyung Na; Young-Joon Surh
Resveratrol suppresses growth of human ovarian cancer cells in culture and in a murine xenograft model: eukaryotic elongation factor 1A2 as a potential target.
Cancer research 2009;69(18):7449-58.
2009: Jin Woo Choi; Jung Yeon Um; Joydip Kundu ; Young-Joon Surh; Sunghoon Kim
Multidirectional tumor-suppressive activity of AIMP2/p38 and the enhanced susceptibility of AIMP2 heterozygous mice to carcinogenesis.
Carcinogenesis 2009;30(9):1638-44.
2009: Young-Joon Surh; Joydip Kundu ; Mei-Hua Li; Hye-Kyung Na; Young-Nam Cha
Role of Nrf2-mediated heme oxygenase-1 upregulation in adaptive survival response to nitrosative stress.
Archives of pharmacal research 2009;32(8):1163-76.
2009: Si-Young Kim; Tae-Won Jun; Young-Soo Lee; Hye-Kyung Na; Young-Joon Surh; Wook Song
Effects of exercise on cyclooxygenase-2 expression and nuclear factor-kappaB DNA binding in human peripheral blood mononuclear cells.
Annals of the New York Academy of Sciences 2009;1171():464-71.
2009: Na-Young Song; Do-Hee Kim; Eun-Hee Kim; Hye-Kyung Na; Young-Joon Surh
15-Deoxy-delta 12, 14-prostaglandin J2 induces upregulation of multidrug resistance-associated protein 1 via Nrf2 activation in human breast cancer cells.
Annals of the New York Academy of Sciences 2009;1171():210-6.
2009: Do-Hee Kim; Eun-Hee Kim; Hye-Kyung Na; Young-Joon Surh
Effects of 15-deoxy-delta 12, 14-prostaglandin J2 on the expression of p53 in MCF-7 cells.
Annals of the New York Academy of Sciences 2009;1171():202-9.
2009: Mee-Hyun Lee; Young-Joon Surh
eEF1A2 as a putative oncogene.
Annals of the New York Academy of Sciences 2009;1171():87-93.
2009: Do-Hee Kim; Jung-Hyun Kim; Eun-Hee Kim; Hye-Kyung Na; Young-Nam Cha; Jin Ho Chung; Young-Joon Surh
15-Deoxy-Delta12,14-prostaglandin J2 upregulates the expression of heme oxygenase-1 and subsequently matrix metalloproteinase-1 in human breast cancer cells: possible roles of iron and ROS.
Carcinogenesis 2009;30(4):645-54.
2009: Sin-Aye Park; Hye-Kyung Na; Eun-Hee Kim; Young-Nam Cha; Young-Joon Surh
4-hydroxyestradiol induces anchorage-independent growth of human mammary epithelial cells via activation of IkappaB kinase: potential role of reactive oxygen species.
Cancer research 2009;69(6):2416-24.
2009: Won-Hee Lee; Joon-Seok Choi; Hyun Young Kim; Jeong Hill Park; Seung-Ki Lee; Young-Joon Surh
Heat-processed neoginseng, KG-135, down-regulates G1 Cyclin-dependent kinase through the proteasome-mediated pathway in HeLa cells.
Oncology reports 2009;21(2):467-74.
2009: Ebenezer Olatunde Farombi; Sangeeta Shrotriya; Young-Joon Surh
Kolaviron inhibits dimethyl nitrosamine-induced liver injury by suppressing COX-2 and iNOS expression via NF-kappaB and AP-1.
Life sciences 2009;84(5-6):149-55.
2009: Joydip Kundu ; Dal-Mi Hwang; Jung-Chul Lee; Eun-Jin Chang; Young Kee Shin; Hajime Fujii; Buxiang Sun; Young-Joon Surh
Inhibitory effects of oligonol on phorbol ester-induced tumor promotion and COX-2 expression in mouse skin: NF-kappaB and C/EBP as potential targets.
Cancer letters 2009;273(1):86-97.
2009: Dan Liu; Do-Hee Kim; Jong-Min Park; Hye-Kyung Na; Young-Joon Surh
Piceatannol inhibits phorbol ester-induced NF-kappa B activation and COX-2 expression in cultured human mammary epithelial cells.
Nutrition and cancer 2009;61(6):855-63.
2009: Jin Youn; Jeong-Sang Lee; Hye-Kyung Na; Joydeb Kumar Kundu; Young-Joon Surh
Resveratrol and piceatannol inhibit iNOS expression and NF-kappaB activation in dextran sulfate sodium-induced mouse colitis.
Nutrition and cancer 2009;61(6):847-54.
2009: Joydip Kundu ; Hye-Kyung Na; Young-Joon Surh
Ginger-derived phenolic substances with cancer preventive and therapeutic potential.
Forum of nutrition 2009;61():182-92.
2008: Ji-Woo Kim; Mei-Hua Li; Jung-Hee Jang; Hye-Kyung Na; Na-Young Song; Chan Lee; Jeffrey A Johnson; Young-Joon Surh
15-Deoxy-Delta(12,14)-prostaglandin J(2) rescues PC12 cells from H2O2-induced apoptosis through Nrf2-mediated upregulation of heme oxygenase-1: potential roles of Akt and ERK1/2.
Biochemical pharmacology 2008;76(11):1577-89.
2008: Eun-Hee Kim; Young-Joon Surh
The role of 15-deoxy-delta(12,14)-prostaglandin J(2), an endogenous ligand of peroxisome proliferator-activated receptor gamma, in tumor angiogenesis.
Biochemical pharmacology 2008;76(11):1544-53.
2008: Joydip Kundu ; Young-Joon Surh
Cancer chemopreventive and therapeutic potential of resveratrol: mechanistic perspectives.
Cancer letters 2008;269(2):243-61.
2008: Young-Joon Surh; Joydip Kundu ; Hye-Kyung Na
Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals.
Planta medica 2008;74(13):1526-39.
2008: Hye-Kyung Na; Eun-Hee Kim; Joo-Hee Jung; Hyun-Hee Lee; Jin Won Hyun; Young-Joon Surh
(-)-Epigallocatechin gallate induces Nrf2-mediated antioxidant enzyme expression via activation of PI3K and ERK in human mammary epithelial cells.
Archives of biochemistry and biophysics 2008;476(2):171-7.
2008: Joydip Kundu ; Young-Joon Surh
Inflammation: gearing the journey to cancer.
Mutation research 2008;659(1-2):15-30.
2008: Eun-Hee Kim; Hye-Kyung Na; Do-Hee Kim; Sin-Aye Park; Ha-Na Kim; Na-Young Song; Young-Joon Surh
15-Deoxy-Delta12,14-prostaglandin J2 induces COX-2 expression through Akt-driven AP-1 activation in human breast cancer cells: a potential role of ROS.
Carcinogenesis 2008;29(4):688-95.
2008: Hye-Kyung Na; Young-Joon Surh
Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea polyphenol EGCG.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008;46(4):1271-8.
2008: Ebenezer Olatunde Farombi; Sangeeta Shrotriya; Hye-Kyung Na; Sung-Hoon Kim; Young-Joon Surh
Curcumin attenuates dimethylnitrosamine-induced liver injury in rats through Nrf2-mediated induction of heme oxygenase-1.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008;46(4):1279-87.
2008: Joydip Kundu ; Eun-Jin Chang; Hajime Fujii; Buxiang Sun; Young-Joon Surh
Oligonol inhibits UVB-induced COX-2 expression in HR-1 hairless mouse skin--AP-1 and C/EBP as potential upstream targets.
Photochemistry and photobiology 2008;84(2):399-406.
2008: Young-Joon Surh; Hye-Kyung Na
NF-kappaB and Nrf2 as prime molecular targets for chemoprevention and cytoprotection with anti-inflammatory and antioxidant phytochemicals.
Genes & nutrition 2008;2(4):313-7.
2008: Dae Young Kwon; Young-Joon Surh
Editorial.
Genes & nutrition 2008;2(4):311-2.
2008: Jung-Hwan Kim; Hye-Kyung Na; Youngmi K Pak; Yun-Sil Lee; Su-Jae Lee; Aree Moon; Young-Joon Surh
Roles of ERK and p38 mitogen-activated protein kinases in phorbol ester-induced NF-kappaB activation and COX-2 expression in human breast epithelial cells.
Chemico-biological interactions 2008;171(2):133-41.
2008: Hyun Soo Kim; Joydeb Kumar Kundu; Jeong-Sang Lee; Tae Young Oh; Hye-Kyung Na; Young-Joon Surh
Chemopreventive effects of the standardized extract (DA-9601) of Artemisia asiatica on azoxymethane-initiated and dextran sulfate sodium-promoted mouse colon carcinogenesis.
Nutrition and cancer 2008;60 Suppl 1():90-7.
2008: Young-Joon Surh
NF-kappa B and Nrf2 as potential chemopreventive targets of some anti-inflammatory and antioxidative phytonutrients with anti-inflammatory and antioxidative activities.
Asia Pacific journal of clinical nutrition 2008;17 Suppl 1():269-72.
2008: Hye-Kyung Na; Young-Joon Surh
The antitumor ether lipid edelfosine (ET-18-O-CH3) induces apoptosis in H-ras transformed human breast epithelial cells: by blocking ERK1/2 and p38 mitogen-activated protein kinases as potential targets.
Asia Pacific journal of clinical nutrition 2008;17 Suppl 1():204-7.
2007: So Young Park; Eun Ji Kim; Hyun-Kyung Shin; Dae Young Kwon; Myung-Sunny Kim; Young-Joon Surh; Jung Han Yoon Park
Induction of apoptosis in HT-29 colon cancer cells by phloretin.
Journal of medicinal food 2007;10(4):581-6.
2007: Eun-Joo Joung; Mei-Hua Li; Hee Geum Lee; Nuntiya Somparn; Young Suk Jung; Hye-Kyung Na; Sung-Hoon Kim; Young-Nam Cha; Young-Joon Surh
Capsaicin induces heme oxygenase-1 expression in HepG2 cells via activation of PI3K-Nrf2 signaling: NAD(P)H:quinone oxidoreductase as a potential target.
Antioxidants & redox signaling 2007;9(12):2087-98.
2007: So-Hyun Park; Jung-Hee Jang; Mei-Hua Li; Hye-Kyung Na; Young-Nam Cha; Young-Joon Surh
Nrf2-mediated heme oxygenase-1 induction confers adaptive survival response to tetrahydropapaveroline-induced oxidative PC12 cell death.
Antioxidants & redox signaling 2007;9(12):2075-86.
2007: Mei-Hua Li; Jung-Hee Jang; Hye-Kyung Na; Young-Nam Cha; Young-Joon Surh
Carbon monoxide produced by heme oxygenase-1 in response to nitrosative stress induces expression of glutamate-cysteine ligase in PC12 cells via activation of phosphatidylinositol 3-kinase and Nrf2 signaling.
The Journal of biological chemistry 2007;282(39):28577-86.
2007: Ki Won Lee; Nam Joo Kang; Evgeny Rogozin; Hong-Gyum Kim; Yong-Yeon Cho; Ann M Bode; Hyong Joo Lee; Young-Joon Surh; George Bowden; Zigang Dong
Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1.
Carcinogenesis 2007;28(9):1918-27.
2007: Young-Joon Surh; Joydip Kundu
Cancer preventive phytochemicals as speed breakers in inflammatory signaling involved in aberrant COX-2 expression.
Current cancer drug targets 2007;7(5):447-58.
2007: Jung-Chul Lee; Joydip Kundu ; Dal-Mi Hwang; Hye-Kyung Na; Young-Joon Surh
Humulone inhibits phorbol ester-induced COX-2 expression in mouse skin by blocking activation of NF-kappaB and AP-1: IkappaB kinase and c-Jun-N-terminal kinase as respective potential upstream targets.
Carcinogenesis 2007;28(7):1491-8.
2007: Kyoung Ah Kang; Kyoung Hwa Lee; Jae Woo Park; Nam Ho Lee; Hye Kyung Na; Young-Joon Surh; Ho Jin You; Myung Hee Chung; Jin Won Hyun
Triphlorethol-A induces heme oxygenase-1 via activation of ERK and NF-E2 related factor 2 transcription factor.
FEBS letters 2007;581(10):2000-8.
2007: Soung Hoo Jeon; Ju-Yong Yoon; Young Nyun Park; Woo-Jeong Jeong; Sewoon Kim; Eek-Hoon Jho; Young-Joon Surh; Kang-Yell Choi
Axin inhibits extracellular signal-regulated kinase pathway by Ras degradation via beta-catenin.
The Journal of biological chemistry 2007;282(19):14482-92.
2007: Jin-Kyoung Kim; Younghwa Kim; Kwang-Min Na; Young-Joon Surh; Tae-Yoon Kim
[6]-Gingerol prevents UVB-induced ROS production and COX-2 expression in vitro and in vivo.
Free radical research 2007;41(5):603-14.
2007: Hye-Seung Jun; Taesun Park; Chang Ki Lee; Mi Kyung Kang; Mi Sun Park; Ho Il Kang; Young-Joon Surh; Ok-Hee Kim
Capsaicin induced apoptosis of B16-F10 melanoma cells through down-regulation of Bcl-2.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2007;45(5):708-15.
2007: Dal-Mi Hwang; Joydip Kundu ; Jun-Wan Shin; Jung-Chul Lee; Hyong Joo Lee; Young-Joon Surh
cis-9,trans-11-conjugated linoleic acid down-regulates phorbol ester-induced NF-kappaB activation and subsequent COX-2 expression in hairless mouse skin by targeting IkappaB kinase and PI3K-Akt.
Carcinogenesis 2007;28(2):363-71.
2007: Young-Joon Surh; Kyung-Soo Chun
Cancer chemopreventive effects of curcumin.
Advances in experimental medicine and biology 2007;595():149-72.
2007: Sin-Aye Park; Eun-Hee Kim; Hye-Kyung Na; Young-Joon Surh
KG-135 inhibits COX-2 expression by blocking the activation of JNK and AP-1 in phorbol ester-stimulated human breast epithelial cells.
Annals of the New York Academy of Sciences 2007;1095():545-53.
2007: Jeong-Sang Lee; Hyun-Soo Kim; Ki-Baik Hahm; Mi-Won Sohn; Moohi Yoo; Jeffrey A Johnson; Young-Joon Surh
Inhibitory effects of 7-carboxymethyloxy-3',4',5-trimethoxyflavone (DA-6034) on Helicobacter pylori-induced NF-kappa B activation and iNOS expression in AGS cells.
Annals of the New York Academy of Sciences 2007;1095():527-35.
2007: Joydip Kundu ; Young-Joon Surh
Epigallocatechin gallate inhibits phorbol ester-induced activation of NF-kappa B and CREB in mouse skin: role of p38 MAPK.
Annals of the New York Academy of Sciences 2007;1095():504-12.
2007: Min-Jung Kim; Do-Hee Kim; Ki Won Lee; Do-Young Yoon; Young-Joon Surh
Jaceosidin induces apoptosis in ras-transformed human breast epithelial cells through generation of reactive oxygen species.
Annals of the New York Academy of Sciences 2007;1095():483-95.
2007: Chu-Yue Chen; Jung-Hee Jang; Mi Hyun Park; Sung Joo Hwang; Young-Joon Surh; Ock Jin Park
Attenuation of Abeta-induced apoptosis of plant extract (Saengshik) mediated by the inhibition of mitochondrial dysfunction and antioxidative effect.
Annals of the New York Academy of Sciences 2007;1095():399-411.
2007: Eun Ji Kim; So Young Park; Hyun-Kyung Shin; Dae Young Kwon; Young-Joon Surh; Jung Han Yoon Park
Activation of caspase-8 contributes to 3,3'-Diindolylmethane-induced apoptosis in colon cancer cells.
The Journal of nutrition 2007;137(1):31-6.
2006: Eun-Hee Kim; Hye-Kyung Na; Young-Joon Surh
Upregulation of VEGF by 15-deoxy-Delta12,14-prostaglandin J2 via heme oxygenase-1 and ERK1/2 signaling in MCF-7 cells.
Annals of the New York Academy of Sciences 2006;1090():375-84.
2006: Joydip Kundu ; Young Kee Shin; Young-Joon Surh
Resveratrol modulates phorbol ester-induced pro-inflammatory signal transduction pathways in mouse skin in vivo: NF-kappaB and AP-1 as prime targets.
Biochemical pharmacology 2006;72(11):1506-15.
2006: Eun-Hee Kim; Young-Joon Surh
15-deoxy-Delta12,14-prostaglandin J2 as a potential endogenous regulator of redox-sensitive transcription factors.
Biochemical pharmacology 2006;72(11):1516-28.
2006: Jin-Taek Hwang; Young Min Kim; Young-Joon Surh; Haing Woon Baik; Seong-Kyu Lee; Joohun Ha; Ock Jin Park
Selenium regulates cyclooxygenase-2 and extracellular signal-regulated kinase signaling pathways by activating AMP-activated protein kinase in colon cancer cells.
Cancer research 2006;66(20):10057-63.
2006: Ki Won Lee; Mi-Sung Kim; Nam Joo Kang; Do-Hee Kim; Young-Joon Surh; Hyong Joo Lee; Aree Moon
H-Ras selectively up-regulates MMP-9 and COX-2 through activation of ERK1/2 and NF-kappaB: an implication for invasive phenotype in rat liver epithelial cells.
International journal of cancer. Journal international du cancer 2006;119(8):1767-75.
2006: Mei-Hua Li; Young-Nam Cha; Young-Joon Surh
Peroxynitrite induces HO-1 expression via PI3K/Akt-dependent activation of NF-E2-related factor 2 in PC12 cells.
Free radical biology & medicine 2006;41(7):1079-91.
2006: Ebenezer Olatunde Farombi; Young-Joon Surh
Heme oxygenase-1 as a potential therapeutic target for hepatoprotection.
Journal of biochemistry and molecular biology 2006;39(5):479-91.
2006: Joydip Kundu ; Young Kee Shin; Sung Hoon Kim; Young-Joon Surh
Resveratrol inhibits phorbol ester-induced expression of COX-2 and activation of NF-kappaB in mouse skin by blocking IkappaB kinase activity.
Carcinogenesis 2006;27(7):1465-74.
2006: Hye-Kyung Na; Young-Joon Surh
Transcriptional regulation via cysteine thiol modification: a novel molecular strategy for chemoprevention and cytoprotection.
Molecular carcinogenesis 2006;45(6):368-80.
2006: Ki Won Lee; Joydip Kundu ; Sue Ok Kim; Kyung-Soo Chun; Hyong Joo Lee; Young-Joon Surh
Cocoa polyphenols inhibit phorbol ester-induced superoxide anion formation in cultured HL-60 cells and expression of cyclooxygenase-2 and activation of NF-kappaB and MAPKs in mouse skin in vivo.
The Journal of nutrition 2006;136(5):1150-5.
2006: Mei-Hua Li; Young-Nam Cha; Young-Joon Surh
Carbon monoxide protects PC12 cells from peroxynitrite-induced apoptotic death by preventing the depolarization of mitochondrial transmembrane potential.
Biochemical and biophysical research communications 2006;342(3):984-90.
2006: Ki-Sook Park; Soung Hoo Jeon; Sung-Eun Kim; Young Yil Bahk; Sheri L Holmen; Bart Williams; Kwang-Chul Chung; Young-Joon Surh; Kang-Yell Choi
APC inhibits ERK pathway activation and cellular proliferation induced by RAS.
Journal of cell science 2006;119(Pt 5):819-27.
2006: Soo Jin Lee; Hiroaki Sakurai; Keiichi Koizumi; Gyu-Yong Song; Yong Soo Bae; Hyung-Min Kim; Kyung-Sun Kang; Young-Joon Surh; Ikuo Saiki; Sung Hoon Kim
MAPK regulation and caspase activation are required in DMNQ S-52 induced apoptosis in Lewis lung carcinoma cells.
Cancer letters 2006;233(1):57-67.
2006: Hye-Kyung Na; Young-Joon Surh
Intracellular signaling network as a prime chemopreventive target of (-)-epigallocatechin gallate.
Molecular nutrition & food research 2006;50(2):152-9.
2006: Jung-Hwan Kim; Ki Won Lee; Min-Won Lee; Hyong Joo Lee; Sung-Hoon Kim; Young-Joon Surh
Hirsutenone inhibits phorbol ester-induced upregulation of COX-2 and MMP-9 in cultured human mammary epithelial cells: NF-kappaB as a potential molecular target.
FEBS letters 2006;580(2):385-92.
2006: Kyung-Soo Chun; Joydeb Kumar Kundu; Kwang-Kyun Park; Won-Yoon Chung; Young-Joon Surh
Inhibition of phorbol ester-induced mouse skin tumor promotion and COX-2 expression by celecoxib: C/EBP as a potential molecular target.
Cancer research and treatment : official journal of Korean Cancer Association 2006;38(3):152-8.
2006: Joydip Kundu ; Kang-Yell Choi; Young-Joon Surh
beta-Catenin-mediated signaling: a novel molecular target for chemoprevention with anti-inflammatory substances.
Biochimica et biophysica acta 2006;1765(1):14-24.
2005: Joydip Kundu ; Young-Joon Surh
Breaking the relay in deregulated cellular signal transduction as a rationale for chemoprevention with anti-inflammatory phytochemicals.
Mutation research 2005;591(1-2):123-46.
2005: Young-Joon Surh; Joydip Kundu ; Hye-Kyung Na; Jeong-Sang Lee
Redox-sensitive transcription factors as prime targets for chemoprevention with anti-inflammatory and antioxidative phytochemicals.
The Journal of nutrition 2005;135(12 Suppl):2993S-3001S.
2005: Jeong-Sang Lee; Tae Young Oh; Young-Kyung Kim; Joo-Hyun Baik; Sung So; Ki-Baik Hahm; Young-Joon Surh
Protective effects of green tea polyphenol extracts against ethanol-induced gastric mucosal damages in rats: stress-responsive transcription factors and MAP kinases as potential targets.
Mutation research 2005;579(1-2):214-24.
2005: Hye-Kyung Na; Hiroyasu Inoue; Young-Joon Surh
ET-18-O-CH3-induced apoptosis is causally linked to COX-2 upregulation in H-ras transformed human breast epithelial cells.
FEBS letters 2005;579(27):6279-87.
2005: Auemduan Prawan; Joydip Kundu ; Young-Joon Surh
Molecular basis of heme oxygenase-1 induction: implications for chemoprevention and chemoprotection.
Antioxidants & redox signaling 2005;7(11-12):1688-703.
2005: Ki Won Lee; Jung-Hwan Kim; Hyong Joo Lee; Young-Joon Surh
Curcumin inhibits phorbol ester-induced up-regulation of cyclooxygenase-2 and matrix metalloproteinase-9 by blocking ERK1/2 phosphorylation and NF-kappaB transcriptional activity in MCF10A human breast epithelial cells.
Antioxidants & redox signaling 2005;7(11-12):1612-20.
2005: Mei-Hua Li; Jung-Hee Jang; Young-Joon Surh
Nitric oxide induces apoptosis via AP-1-driven upregulation of COX-2 in rat pheochromocytoma cells.
Free radical biology & medicine 2005;39(7):890-9.
2005: Zhi-Hua Chen; Hye-Kyung Na; Yeon-Jin Hurh; Young-Joon Surh
4-Hydroxyestradiol induces oxidative stress and apoptosis in human mammary epithelial cells: possible protection by NF-kappaB and ERK/MAPK.
Toxicology and applied pharmacology 2005;208(1):46-56.
2005: Jeong-Eun Huh; Eun-Ok Lee; Min-Seok Kim; Kyung-Sun Kang; Cheol-Ho Kim; Bae-Cheon Cha; Young-Joon Surh; Sung-Hoon Kim
Penta-O-galloyl-beta-D-glucose suppresses tumor growth via inhibition of angiogenesis and stimulation of apoptosis: roles of cyclooxygenase-2 and mitogen-activated protein kinase pathways.
Carcinogenesis 2005;26(8):1436-45.
2005: Jeong-Sang Lee; Young-Joon Surh
Nrf2 as a novel molecular target for chemoprevention.
Cancer letters 2005;224(2):171-84.
2005: Jung-Hee Jang; Young-Joon Surh
AP-1 mediates beta-amyloid-induced iNOS expression in PC12 cells via the ERK2 and p38 MAPK signaling pathways.
Biochemical and biophysical research communications 2005;331(4):1421-8.
2005: Chu-Yue Chen; Jung-Hee Jang; Mei-Hua Li; Young-Joon Surh
Resveratrol upregulates heme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cells.
Biochemical and biophysical research communications 2005;331(4):993-1000.
2005: Jung-Hee Jang; Young-Joon Surh
Beta-amyloid-induced apoptosis is associated with cyclooxygenase-2 up-regulation via the mitogen-activated protein kinase-NF-kappaB signaling pathway.
Free radical biology & medicine 2005;38(12):1604-13.
2005: Sue Ok Kim; Joydip Kundu ; Young Kee Shin; Jin-Hong Park; Myung-Haing Cho; Tae-Yoon Kim; Young-Joon Surh
[6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kappaB in phorbol ester-stimulated mouse skin.
Oncogene 2005;24(15):2558-67.
2005: Ji-Yoon Lee; Jun-Wan Shin; Kyung-Soo Chun; Kwan-Kyu Park; Won-Yoon Chung; Yung-Jue Bang; Jong-Hwan Sung; Young-Joon Surh
Antitumor promotional effects of a novel intestinal bacterial metabolite (IH-901) derived from the protopanaxadiol-type ginsenosides in mouse skin.
Carcinogenesis 2005;26(2):359-67.
2005: Joydip Kundu ; Kensese S Mossanda; Hye-Kyung Na; Young-Joon Surh
Inhibitory effects of the extracts of Sutherlandia frutescens (L.) R. Br. and Harpagophytum procumbens DC. on phorbol ester-induced COX-2 expression in mouse skin: AP-1 and CREB as potential upstream targets.
Cancer letters 2005;218(1):21-31.
2005: Do-Hee Kim; Hye-Kyung Na; Tae Young Oh; Chang Yell Shin; Young-Joon Surh
Eupatilin inhibits proliferation of ras-transformed human breast epithelial (MCF-10A-ras) cells.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 2005;24(4):251-9.
2005: Byung Moo Yoo; Tae Young Oh; Young-Bae Kim; Marie Yeo; Jeong-Sang Lee; Young-Joon Surh; Byoung Ok Ahn; Wook-Hwan Kim; Seonghyang Sohn; Jin-Hong Kim; Ki-Baik Hahm
Novel antioxidant ameliorates the fibrosis and inflammation of cerulein-induced chronic pancreatitis in a mouse model.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2005;5(2-3):165-76.
2005: Young-Joon Surh; Joydip Kundu
Signal transduction network leading to COX-2 induction: a road map in search of cancer chemopreventives.
Archives of pharmacal research 2005;28(1):1-15.
2004: Ki Won Lee; Kyung-Soo Chun; Jeong-Sang Lee; Kyung-Sun Kang; Young-Joon Surh; Hyong Joo Lee
Inhibition of cyclooxygenase-2 expression and restoration of gap junction intercellular communication in H-ras-transformed rat liver epithelial cells by caffeic acid phenethyl ester.
Annals of the New York Academy of Sciences 2004;1030():501-7.
2004: Eun-Hee Kim; Do-Hee Kim; Hye-Kyung Na; Young-Joon Surh
Effects of cyclopentenone prostaglandins on the expression of heme oxygenase-1 in MCF-7 cells.
Annals of the New York Academy of Sciences 2004;1030():493-500.
2004: Mei-Hua Li; Jung-Hee Jang; Buxiang Sun; Young-Joon Surh
Protective effects of oligomers of grape seed polyphenols against beta-amyloid-induced oxidative cell death.
Annals of the New York Academy of Sciences 2004;1030():317-29.
2004: Yeon-Jin Hurh; Zhi-Hua Chen; Hye-Kyung Na; Soon-Young Han; Young-Joon Surh
2-Hydroxyestradiol induces oxidative DNA damage and apoptosis in human mammary epithelial cells.
Journal of toxicology and environmental health. Part A 2004;67(23-24):1939-53.
2004: Joydip Kundu ; Young-Joon Surh
Molecular basis of chemoprevention by resveratrol: NF-kappaB and AP-1 as potential targets.
Mutation research 2004;555(1-2):65-80.
2004: So-Young Lim; Jung-Hee Jang; Hye-Kyung Na; Shelly C Lu; Irfan Rahman; Young-Joon Surh
15-Deoxy-Delta12,14-prostaglandin J(2) protects against nitrosative PC12 cell death through up-regulation of intracellular glutathione synthesis.
The Journal of biological chemistry 2004;279(44):46263-70.
2004: Young-Joon Surh
Transcription factors in the cellular signaling network as prime targets of chemopreventive phytochemicals.
Cancer research and treatment : official journal of Korean Cancer Association 2004;36(5):275-86.
2004: Seong-Su Han; Kihyun Kim; Eun-Ryeong Hahm; Sook J Lee; Young-Joon Surh; Hye K Park; Won S Kim; Chul Won Jung; Mark H Lee; Keunchil Park; Jung-Hyun Yang; Sung-Soo Yoon; Neil Riordan; Hugh D Riordan; Bruce F Kimler; Chan H Park; Je-Ho Lee; Seyeon Park
L-ascorbic acid represses constitutive activation of NF-kappaB and COX-2 expression in human acute myeloid leukemia, HL-60.
Journal of cellular biochemistry 2004;93(2):257-70.
2004: Zhi-Hua Chen; Yeon-Jin Hurh; Hye-Kyung Na; Jung-Hwan Kim; Young-Jin Chun; Dong-Hyun Kim; Kyung-Sun Kang; Myung-Haing Cho; Young-Joon Surh
Resveratrol inhibits TCDD-induced expression of CYP1A1 and CYP1B1 and catechol estrogen-mediated oxidative DNA damage in cultured human mammary epithelial cells.
Carcinogenesis 2004;25(10):2005-13.
2004: Kyung-Soo Chun; Young-Joon Surh
Signal transduction pathways regulating cyclooxygenase-2 expression: potential molecular targets for chemoprevention.
Biochemical pharmacology 2004;68(6):1089-100.
2004: Do-Hee Kim; Hye-Kyung Na; Tae Young Oh; Won Bae Kim; Young-Joon Surh
Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces cell cycle arrest in ras-transformed human mammary epithelial cells.
Biochemical pharmacology 2004;68(6):1081-7.
2004: Jung-Hee Jang; Young-Joon Surh
Bcl-2 attenuation of oxidative cell death is associated with up-regulation of gamma-glutamylcysteine ligase via constitutive NF-kappaB activation.
The Journal of biological chemistry 2004;279(37):38779-86.
2004: Su-Hyeong Kim; Sang-Hyun Song; Sang-Gyun Kim; Kyung-Soo Chun; So-Young Lim; Hye-Kyung Na; Jae Weon Kim; Young-Joon Surh; Yung-Jue Bang; Yong-Sang Song
Celecoxib induces apoptosis in cervical cancer cells independent of cyclooxygenase using NF-kappaB as a possible target.
Journal of cancer research and clinical oncology 2004;130(9):551-60.
2004: Jung-Hee Jang; Young-Joon Surh
Bcl-2 protects against Abeta(25-35)-induced oxidative PC12 cell death by potentiation of antioxidant capacity.
Biochemical and biophysical research communications 2004;320(3):880-6.
2004: Akira Murakami; Takuji Tanaka; Ji-Yoon Lee; Young-Joon Surh; Ha Won Kim; Kyuichi Kawabata; Yoshimasa Nakamura; Suratwadee Jiwajinda; Hajime Ohigashi
Zerumbone, a sesquiterpene in subtropical ginger, suppresses skin tumor initiation and promotion stages in ICR mice.
International journal of cancer. Journal international du cancer 2004;110(4):481-90.
2004: Mi-Hyun Shin; Jung-Hee Jang; Young-Joon Surh
Potential roles of NF-kappaB and ERK1/2 in cytoprotection against oxidative cell death induced by tetrahydropapaveroline.
Free radical biology & medicine 2004;36(9):1185-94.
2004: Kyung-Soo Chun; Su-Hyeong Kim; Yong-Sang Song; Young-Joon Surh
Celecoxib inhibits phorbol ester-induced expression of COX-2 and activation of AP-1 and p38 MAP kinase in mouse skin.
Carcinogenesis 2004;25(5):713-22.
2004: Ock Jin Park; Young-Joon Surh
Chemopreventive potential of epigallocatechin gallate and genistein: evidence from epidemiological and laboratory studies.
Toxicology letters 2004;150(1):43-56.
2004: Kyung-Soo Chun; Hyun-Ho Cha; Jun-Wan Shin; Hye-Kyung Na; Kwan-Kyu Park; Won-Yoon Chung; Young-Joon Surh
Nitric oxide induces expression of cyclooxygenase-2 in mouse skin through activation of NF-kappaB.
Carcinogenesis 2004;25(3):445-54.
2004: Jung-Hee Jang; Okezie I Aruoma; Ling-Sun Jen; Hae Young Chung; Young-Joon Surh
Ergothioneine rescues PC12 cells from beta-amyloid-induced apoptotic death.
Free radical biology & medicine 2004;36(3):288-99.
2004: Jung-Hee Jang; Young-Joon Surh
Possible role of NF-kappaB in Bcl-X(L) protection against hydrogen peroxide-induced PC12 cell death.
Redox report : communications in free radical research 2004;9(6):343-8.
2004: Hye-Kyung Na; Kensese S Mossanda; Ji-Yoon Lee; Young-Joon Surh
Inhibition of phorbol ester-induced COX-2 expression by some edible African plants.
BioFactors (Oxford, England) 2004;21(1-4):149-53.
2004: Young-Joon Surh; Hye-Kyung Na; Seung Sei Lee
Transcription factors and mitogen-activated protein kinases as molecular targets for chemoprevention with anti-inflammatory phytochemicals.
BioFactors (Oxford, England) 2004;21(1-4):103-8.
2004: Joydip Kundu ; Kyung-Soo Chun; Sue Ok Kim; Young-Joon Surh
Resveratrol inhibits phorbol ester-induced cyclooxygenase-2 expression in mouse skin: MAPKs and AP-1 as potential molecular targets.
BioFactors (Oxford, England) 2004;21(1-4):33-9.
2004: Sue Ok Kim; Kyung-Soo Chun; Joydip Kundu ; Young-Joon Surh
Inhibitory effects of [6]-gingerol on PMA-induced COX-2 expression and activation of NF-kappaB and p38 MAPK in mouse skin.
BioFactors (Oxford, England) 2004;21(1-4):27-31.
2003: So-Young Lim; Jung-Hee Jang; Young-Joon Surh
Induction of cyclooxygenase-2 and peroxisome proliferator-activated receptor-gamma during nitric oxide-induced apoptotic PC12 cell death.
Annals of the New York Academy of Sciences 2003;1010():648-58.
2003: Lan Yuan; Chihiro Wagatsuma; Buxiang Sun; Jung-Hwan Kim; Young-Joon Surh
The role of beta-glucuronidase in induction of apoptosis by genistein combined polysaccharide (GCP) in xenogeneic mice bearing human mammary cancer cells.
Annals of the New York Academy of Sciences 2003;1010():347-9.
2003: Ki Won Lee; Hyong Joo Lee; Young-Joon Surh; Chang Yong Lee
Vitamin C and cancer chemoprevention: reappraisal.
The American journal of clinical nutrition 2003;78(6):1074-8.
2003: Yunjo Soh; Mi-Hyun Shin; Jeong-Sang Lee; Jung-Hee Jang; Ok Hee Kim; Hoil Kang; Young-Joon Surh
Oxidative DNA damage and glioma cell death induced by tetrahydropapaveroline.
Mutation research 2003;544(2-3):129-42.
2003: Joydip Kundu ; Hye-Kyung Na; Kyung-Soo Chun; Young-Kyung Kim; Sang Jun Lee; Sang Sup Lee; Ok-Sub Lee; Young-Chul Sim; Young-Joon Surh
Inhibition of phorbol ester-induced COX-2 expression by epigallocatechin gallate in mouse skin and cultured human mammary epithelial cells.
The Journal of nutrition 2003;133(11 Suppl 1):3805S-3810S.
2003: Young-Ho Kim; Jong-Wook Park; Jai-Youl Lee; Young-Joon Surh; Taeg Kyu Kwon
Bcl-2 overexpression prevents daunorubicin-induced apoptosis through inhibition of XIAP and Akt degradation.
Biochemical pharmacology 2003;66(9):1779-86.
2003: Hye-Kyung Na; Young-Joon Surh
Peroxisome proliferator-activated receptor gamma (PPARgamma) ligands as bifunctional regulators of cell proliferation.
Biochemical pharmacology 2003;66(8):1381-91.
2003: Jung-Hee Jang; Young-Joon Surh
Potentiation of cellular antioxidant capacity by Bcl-2: implications for its antiapoptotic function.
Biochemical pharmacology 2003;66(8):1371-9.
2003: Young-Joon Surh
Cancer chemoprevention with dietary phytochemicals.
Nature reviews. Cancer 2003;3(10):768-80.
2003: Chan Young Shin; Jieun Shin; Byung-Moon Kim; Myeong-Hyeon Wang; Jung-Hee Jang; Young-Joon Surh; Uhtaek Oh
Essential role of mitochondrial permeability transition in vanilloid receptor 1-dependent cell death of sensory neurons.
Molecular and cellular neurosciences 2003;24(1):57-68.
2003: Kyung-Soo Chun; Young-Sam Keum; Seong Su Han; Yong-Sang Song; Su-Hyeong Kim; Young-Joon Surh
Curcumin inhibits phorbol ester-induced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and NF-kappaB activation.
Carcinogenesis 2003;24(9):1515-24.
2003: Ki-Baik Hahm; D H Kim; K M Lee; J S Lee; Young-Joon Surh; YB Kim; Byung Moo Yoo; Jin Hong Kim; Hee-Jae Joo; Yong Kwan Cho; Ki Taek Nam; Sung Won Cho
Effect of long-term administration of rebamipide on Helicobacter pylori infection in mice.
Alimentary pharmacology & therapeutics 2003;18 Suppl 1():24-38.
2003: Jung-Hee Jang; Young-Joon Surh
Protective effect of resveratrol on beta-amyloid-induced oxidative PC12 cell death.
Free radical biology & medicine 2003;34(8):1100-10.
2003: Hye-Jung Kang; Yunjo Soh; Mi-Sung Kim; Eun-Jung Lee; Young-Joon Surh; Hyeong-Reh Choi Kim; Seung Hee Kim; Aree Moon
Roles of JNK-1 and p38 in selective induction of apoptosis by capsaicin in ras-transformed human breast epithelial cells.
International journal of cancer. Journal international du cancer 2003;103(4):475-82.
2003: Young-Sam Keum; Seong Su Han; Kyung-Soo Chun; Kwan-Kyu Park; Jeong Hill Park; Seung Ki Lee; Young-Joon Surh
Inhibitory effects of the ginsenoside Rg3 on phorbol ester-induced cyclooxygenase-2 expression, NF-kappaB activation and tumor promotion.
Mutation research 2003;523-524():75-85.
2003: Lan Yuan; Chihiro Wagatsuma; Mayumi Yoshida; Takehito Miura; Tomomi Mukoda; Hajime Fujii; Buxiang Sun; Jung-Hwan Kim; Young-Joon Surh
Inhibition of human breast cancer growth by GCP (genistein combined polysaccharide) in xenogeneic athymic mice: involvement of genistein biotransformation by beta-glucuronidase from tumor tissues.
Mutation research 2003;523-524():55-62.
2003: Young-Joon Surh; Lynnette Ferguson
Dietary and medicinal antimutagens and anticarcinogens: molecular mechanisms and chemopreventive potential--highlights of a symposium.
Mutation research 2003;523-524():1-8.
2003: Ki-Baik Hahm; Young Joon Song; Tae Young Oh; Jeong Sang Lee; Young-Joon Surh; Young Bae Kim; Byung Moo Yoo; Jin Hong Kim; Sang-Uk Han; Ki Taik Nahm; Myung-Wook Kim; Dae Yong Kim; Sung Won Cho
Chemoprevention of Helicobacter pylori-associated gastric carcinogenesis in a mouse model: is it possible?
Journal of biochemistry and molecular biology 2003;36(1):82-94.
2002: Young-Joon Surh; Ji-Yoon Lee; Kang-Ju Choi; Sung-Ryong Ko
Effects of selected ginsenosides on phorbol ester-induced expression of cyclooxygenase-2 and activation of NF-kappaB and ERK1/2 in mouse skin.
Annals of the New York Academy of Sciences 2002;973():396-401.
2002: Jung-Hee Jang; Young-Joon Surh
beta-Amyloid induces oxidative DNA damage and cell death through activation of c-Jun N terminal kinase.
Annals of the New York Academy of Sciences 2002;973():228-36.
2002: Hye-Kyung Na; Young-Joon Surh
Induction of cyclooxygenase-2 in Ras-transformed human mammary epithelial cells undergoing apoptosis.
Annals of the New York Academy of Sciences 2002;973():153-60.
2002: Young-Joon Surh
More than spice: capsaicin in hot chili peppers makes tumor cells commit suicide.
Journal of the National Cancer Institute 2002;94(17):1263-5.
2002: Seong-Su Han; Young-Sam Keum; Kyung-Soo Chun; Young-Joon Surh
Suppression of phorbol ester-induced NF-kappaB activation by capsaicin in cultured human promyelocytic leukemia cells.
Archives of pharmacal research 2002;25(4):475-9.
2002: Hyo-Joung Seo; Kwan-Kyu Park; Seong Su Han; Won-Yoon Chung; Mi-Won Son; Won Bae Kim; Young-Joon Surh
Inhibitory effects of the standardized extract (DA-9601) of Artemisia asiatica Nakai on phorbol ester-induced ornithine decarboxylase activity, papilloma formation, cyclooxygenase-2 expression, inducible nitric oxide synthase expression and nuclear transcription factor kappa B activation in mouse skin.
International journal of cancer. Journal international du cancer 2002;100(4):456-62.
2002: Young-Joon Surh
Anti-tumor promoting potential of selected spice ingredients with antioxidative and anti-inflammatory activities: a short review.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2002;40(8):1091-7.
2002: Seong-Su Han; Young-Sam Keum; Hyo-Joung Seo; Young-Joon Surh
Curcumin suppresses activation of NF-kappaB and AP-1 induced by phorbol ester in cultured human promyelocytic leukemia cells.
Journal of biochemistry and molecular biology 2002;35(3):337-42.
2002: Young-Sam Keum; Jin Kim; Keun Hyung Lee; Kwan-Kyu Park; Young-Joon Surh; Jong Min Lee; Sang Sup Lee; Jung Hoon Yoon; So Yeon Joo; In-Ho Cha; Jong In Yook
Induction of apoptosis and caspase-3 activation by chemopreventive [6]-paradol and structurally related compounds in KB cells.
Cancer letters 2002;177(1):41-7.
2002: Young-Joon Surh; Youn-Joo Jung; Jung-Hee Jang; Jeong-Sang Lee; Hye-Ran Yoon
Iron enhancement of oxidative DNA damage and neuronal cell death induced by salsolinol.
Journal of toxicology and environmental health. Part A 2002;65(5-6):473-88.
2002: Kyung-Soo Chun; Kwan-Kyu Park; Jeewoo Lee; Myungshin Kang; Young-Joon Surh
Inhibition of mouse skin tumor promotion by anti-inflammatory diarylheptanoids derived from Alpinia oxyphylla Miquel (Zingiberaceae).
Oncology research 2002;13(1):37-45.
2002: Ki-Baik Hahm; Ho-Yeong Lim; Seongbyang Sohn; Hyuk-Jae Kwon; K-Myung Lee; Jeong-Sang Lee; Young-Joon Surh; Young-Bae Kim; Hee-Jae Joo; Won-Seok Kim; Seung-Won Cho
In vitro evidence of the role of COX-2 in attenuating gastric inflammation and promoting gastric carcinogenesis.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 2002;21(2):165-76.
2002: Kyung-Soo Chun; Jee-Young Kang; Ok Hee Kim; Hoil Kang; Young-Joon Surh
Effects of yakuchinone A and yakuchinone B on the phorbol ester-induced expression of COX-2 and iNOS and activation of NF-kappaB in mouse skin.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 2002;21(2):131-9.
2001: Young-Joon Surh; Hye-Kyung Na; J Y Lee; Young-Sam Keum
Molecular mechanisms underlying anti-tumor promoting activities of heat-processed Panax ginseng C.A. Meyer.
Journal of Korean medical science 2001;16 Suppl():S38-41.
2001: Hyo-Joung Seo; Young-Joon Surh
Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces apoptosis in human promyelocytic leukemia cells.
Mutation research 2001;496(1-2):191-8.
2001: J H Jang; Young-Joon Surh
Protective effects of resveratrol on hydrogen peroxide-induced apoptosis in rat pheochromocytoma (PC12) cells.
Mutation research 2001;496(1-2):181-90.
2001: Young-Joon Surh; Kyung-Soo Chun; H H Cha; Seong Su Han; Young-Sam Keum; Kwan-Kyu Park; Sang Sup Lee
Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation.
Mutation research 2001;480-481():243-68.
2001: Jeong-Sang Lee; Tae Young Oh; Byoung Ok Ahn; H Cho; Won Bae Kim; Y B Kim; Young-Joon Surh; H J Kim; Ki-Baik Hahm
Involvement of oxidative stress in experimentally induced reflux esophagitis and Barrett's esophagus: clue for the chemoprevention of esophageal carcinoma by antioxidants.
Mutation research 2001;480-481():189-200.
2001: Y Jung; Young-Joon Surh
Oxidative DNA damage and cytotoxicity induced by copper-stimulated redox cycling of salsolinol, a neurotoxic tetrahydroisoquinoline alkaloid.
Free radical biology & medicine 2001;30(12):1407-17.
2001: Seong Su Han; Young-Sam Keum; Hyo-Joung Seo; Kyung-Soo Chun; Sang Sup Lee; Young-Joon Surh
Capsaicin suppresses phorbol ester-induced activation of NF-kappaB/Rel and AP-1 transcription factors in mouse epidermis.
Cancer letters 2001;164(2):119-26.
2001: Y J Jung; J Y Youn; Jae-Chun Ryu; Young-Joon Surh
Salsolinol, a naturally occurring tetrahydroisoquinoline alkaloid, induces DNA damage and chromosomal aberrations in cultured Chinese hamster lung fibroblast cells.
Mutation research 2001;474(1-2):25-33.
2000: Young-Sam Keum; Kwan-Kyu Park; J M Lee; Kyung-Soo Chun; Jeong Hill Park; Sang Kook Lee; H Kwon; Young-Joon Surh
Antioxidant and anti-tumor promoting activities of the methanol extract of heat-processed ginseng.
Cancer letters 2000;150(1):41-8.
2000: Young-Joon Surh; Seong Su Han; Young-Sam Keum; Hyo-Joung Seo; Sang Sup Lee
Inhibitory effects of curcumin and capsaicin on phorbol ester-induced activation of eukaryotic transcription factors, NF-kappaB and AP-1.
BioFactors (Oxford, England) 2000;12(1-4):107-12.
1999: Gu Kong; S J Lee; H J Kim; Young-Joon Surh; ND Kim
Induction of granulocytic differentiation in acute promyelocytic leukemia cells (HL-60) by 2-(allylthio) pyrazine.
Cancer letters 1999;144(1):1-8.
1999: E Lee; Gu Kong; S J Lee; ND Kim; Young-Joon Surh
2-(allylthio)pyrazine suppresses the growth and proliferation of human promyelocytic leukemia (HL-60) cells via induction of apoptosis.
Anticancer research 1999;19(5B):4073-80.
1999: Young-Joon Surh
Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances.
Mutation research 1999;428(1-2):305-27.
1999: TG Ha; W C Mar; Sang Geon Kim; Young-Joon Surh; ND Kim
Enhancement of biliary excretion of aflatoxin B(1) and suppression of hepatic ornithine decarboxylase activity by 2-(allylthio)pyrazine in rats.
Mutation research 1999;428(1-2):59-67.
1999: Kyung-Soo Chun; Yeowon Sohn; Hak-Sung Kim; O H Kim; Kwan-Kyu Park; JM Lee; Aree Moon; Sang Sup Lee; Young-Joon Surh
Anti-tumor promoting potential of naturally occurring diarylheptanoids structurally related to curcumin.
Mutation research 1999;428(1-2):49-57.
1999: Young-Joon Surh; Y J Hurh; J Y Kang; E Lee; G Kong; S J Lee
Resveratrol, an antioxidant present in red wine, induces apoptosis in human promyelocytic leukemia (HL-60) cells.
Cancer letters 1999;140(1-2):1-10.
1999: Young-Joon Surh; Sang Geon Kim; A Liem; J W Lee; J A Miller
Inhibitory effects of isopropyl-2-(1,3-dithietane-2-ylidene)-2- [N-(4-methylthiazol-2-yl)carbamoyl]acetate (YH439) on benzo[a]pyrene-induced skin carcinogenesis and micronucleated reticulocyte formation in mice.
Mutation research 1999;423(1-2):149-53.
1999: Young-Joon Surh; Kwan-Kyu Park; Kyung-Soo Chun; L J Lee; E Lee; Sang Sup Lee
Anti-tumor-promoting activities of selected pungent phenolic substances present in ginger.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 1999;18(2):131-9.
1998: E Lee; Young-Joon Surh
Induction of apoptosis in HL-60 cells by pungent vanilloids, [6]-gingerol and [6]-paradol.
Cancer letters 1998;134(2):163-8.
1998: Kwan-Kyu Park; K S Chun; J I Yook; Young-Joon Surh
Lack of tumor promoting activity of capsaicin, a principal pungent ingredient of red pepper, in mouse skin carcinogenesis.
Anticancer research 1998;18(6A):4201-5.
1998: E Lee; Kwan-Kyu Park; JM Lee; Kyung-Soo Chun; J Y Kang; S S Lee; Young-Joon Surh
Suppression of mouse skin tumor promotion and induction of apoptosis in HL-60 cells by Alpinia oxyphylla Miquel (Zingiberaceae).
Carcinogenesis 1998;19(8):1377-81.
1998: Kwan-Kyu Park; K S Chun; J M Lee; Sang Sup Lee; Young-Joon Surh
Inhibitory effects of [6]-gingerol, a major pungent principle of ginger, on phorbol ester-induced inflammation, epidermal ornithine decarboxylase activity and skin tumor promotion in ICR mice.
Cancer letters 1998;129(2):139-44.
1998: Young-Joon Surh; Sang Geon Kim; Kwan-Kyu Park; Y Sohn; J M Lee; ND Kim; JA Miller
Chemopreventive effects of 2-(allylthio)pyrazine on hepatic lesion, mutagenesis and tumorigenesis induced by vinyl carbamate or vinyl carbamate epoxide.
Carcinogenesis 1998;19(7):1263-7.
1998: Young-Joon Surh; E Lee; JM Lee
Chemoprotective properties of some pungent ingredients present in red pepper and ginger.
Mutation research 1998;402(1-2):259-67.
1998: Young-Joon Surh
Bioactivation of benzylic and allylic alcohols via sulfo-conjugation.
Chemico-biological interactions 1998;109(1-3):221-35.
1997: Kwan-Kyu Park; Young-Joon Surh
Effects of capsaicin on chemically-induced two-stage mouse skin carcinogenesis.
Cancer letters 1997;114(1-2):183-4.
1996: Y S Cho; B Y Kim; S T Lee; Young-Joon Surh; An-Sik Chung
Chemopreventive effect of chlorophyllin on mutagenicity and cytotoxicity of 6-sulfooxymethylbenzo[a]pyrene.
Cancer letters 1996;107(2):223-8.
1996: Young-Joon Surh; M Shlyankevich; J W Lee; J K Yoo
Inhibition of covalent DNA binding and mutagenicity of benzo[a]pyrene by isopropyl-2-(1,3-dithietane-2-ylidene)-2-[N-(4-methylthiazol-2-yl) carbamoyl]acetate (YH439), a novel hepatoprotective agent.
Mutation research 1996;367(4):219-24.
1996: Young-Joon Surh
Sulfotransferase-mediated activation of some benzylic and allylic alcohols.
Advances in experimental medicine and biology 1996;387():339-45.
1995: H K Jeong; M Shlyankevich; Young-Joon Surh
Intrinsic mutagenicity and electrophilicity of 1-sulfooxy-3-methylcholanthrene: implications for metabolic activation of the carcinogen 3-methylcholanthrene.
Biochemistry and molecular biology international 1995;37(5):885-93.
1995: Young-Joon Surh; R C Lee; Kwan-Kyu Park; S T Mayne; A Liem; JA Miller
Chemoprotective effects of capsaicin and diallyl sulfide against mutagenesis or tumorigenesis by vinyl carbamate and N-nitrosodimethylamine.
Carcinogenesis 1995;16(10):2467-71.
1995: Young-Joon Surh; Kwan-Kyu Park; M Shlyankevich
Inhibitory effects of chlorophyllin on chemically induced mutagenesis and carcinogenesis.
Annals of the New York Academy of Sciences 1995;768():246-9.
1995: Young-Joon Surh; S R Tannenbaum
Sulfotransferase-mediated activation of 7,8,9,10-tetrahydro-7-ol, 7,8-dihydrodiol, and 7,8,9,10-tetraol derivatives of benzo[a]pyrene.
Chemical research in toxicology 1995;8(5):693-8.
1995: Y C Lee; M Shlyankevich; H K Jeong; J S Douglas; Young-Joon Surh
Bioactivation of 5-hydroxymethyl-2-furaldehyde to an electrophilic and mutagenic allylic sulfuric acid ester.
Biochemical and biophysical research communications 1995;209(3):996-1002.
1995: Young-Joon Surh; S H Ahn; K C Kim; J B Park; Y W Sohn; S S Lee
Metabolism of capsaicinoids: evidence for aliphatic hydroxylation and its pharmacological implications.
Life sciences 1995;56(16):PL305-11.
1995: Young-Joon Surh; S S Lee
Capsaicin, a double-edged sword: toxicity, metabolism, and chemopreventive potential.
Life sciences 1995;56(22):1845-55.
1994: Young-Joon Surh; A Liem; JA Miller; S R Tannenbaum
5-Sulfooxymethylfurfural as a possible ultimate mutagenic and carcinogenic metabolite of the Maillard reaction product, 5-hydroxymethylfurfural.
Carcinogenesis 1994;15(10):2375-7.
1994: Young-Joon Surh; JA Miller
Roles of electrophilic sulfuric acid ester metabolites in mutagenesis and carcinogenesis by some polynuclear aromatic hydrocarbons.
Chemico-biological interactions 1994;92(1-3):351-62.
1994: Young-Joon Surh; Sang Sup Lee
Enzymatic reduction of xenobiotic alpha,beta-unsaturated ketones: formation of allyl alcohol metabolites from shogaol and dehydroparadol.
Research communications in chemical pathology and pharmacology 1994;84(1):53-61.
1994: Young-Joon Surh; S S Lee
Enzymic reduction of [6]-gingerol, a major pungent principle of ginger, in the cell-free preparation of rat liver.
Life sciences 1994;54(19):PL321-6.
1992: Young-Joon Surh; Sang Sup Lee
Enzymatic reduction of shogaol: a novel biotransformation pathway for the alpha,beta-unsaturated ketone system.
Biochemistry international 1992;27(1):179-87.
1991: Young-Joon Surh; A Liem; E C Miller; JA Miller
7-Sulfooxymethyl-12-methylbenz[a]anthracene is an electrophilic mutagen, but does not appear to play a role in carcinogenesis by 7,12-dimethylbenz[a]anthracene or 7-hydroxymethyl-12-methylbenz[a]anthracene.
Carcinogenesis 1991;12(2):339-47.
1991: Young-Joon Surh; A Liem; E C Miller; JA Miller
Age- and sex-related differences in activation of the carcinogen 7-hydroxymethyl-12-methylbenz[a]anthracene to an electrophilic sulfuric acid ester metabolite in rats. Possible involvement of hydroxysteroid sulfotransferase activity.
Biochemical pharmacology 1991;41(2):213-21.
1991: Young-Joon Surh; J C Blomquist; JA Miller
Activation of 1-hydroxymethylpyrene to an electrophilic and mutagenic metabolite by rat hepatic sulfotransferase activity.
Advances in experimental medicine and biology 1991;283():383-91.
1991: JA Miller; Young-Joon Surh; A Liem; E C Miller
Electrophilic sulfuric acid ester metabolites of hydroxy-methyl aromatic hydrocarbons as precursors of hepatic benzylic DNA adducts in vivo.
Advances in experimental medicine and biology 1991;283():555-67.
1990: Young-Joon Surh; A Liem; E C Miller; JA Miller
The strong hepatocarcinogenicity of the electrophilic and mutagenic metabolite 6-sulfooxymethylbenzo[a]pyrene and its formation of benzylic DNA adducts in the livers of infant male B6C3F1 mice.
Biochemical and biophysical research communications 1990;172(1):85-91.
1990: Young-Joon Surh; J C Blomquist; A Liem; JA Miller
Metabolic activation of 9-hydroxymethyl-10-methylanthracene and 1-hydroxymethylpyrene to electrophilic, mutagenic and tumorigenic sulfuric acid esters by rat hepatic sulfotransferase activity.
Carcinogenesis 1990;11(9):1451-60.
1989: Young-Joon Surh; A Liem; E C Miller; JA Miller
Metabolic activation of the carcinogen 6-hydroxymethylbenzo[a]pyrene: formation of an electrophilic sulfuric acid ester and benzylic DNA adducts in rat liver in vivo and in reactions in vitro.
Carcinogenesis 1989;10(8):1519-28.