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Annmarie Surprenant

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Weihong Ma; Elizabeth Martin; R Alan North; Alexei Verkhratsky; Wenxuan Zheng; Vincent Compan; Annmarie Surprenant
Pannexin 1 forms an anion-selective channel.
B Jelassi; A Chantôme; F Alcaraz-Pérez; Alberto Baroja-Mazo; M L Cayuela; Pablo Pelegrin; Annmarie Surprenant; Sébastien Roger
P2X(7) receptor activation enhances SK3 channels- and cystein cathepsin-dependent cancer cells invasiveness.
Gloria Lopez-Castejon; Jill Theaker; Pablo Pelegrin; Andrew D Clifton; Martin Braddock; Annmarie Surprenant
P2X(7) receptor-mediated release of cathepsins from macrophages is a cytokine-independent mechanism potentially involved in joint diseases.

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All Publications

2012: Weihong Ma; Elizabeth Martin; R Alan North; Alexei Verkhratsky; Wenxuan Zheng; Vincent Compan; Annmarie Surprenant
Pannexin 1 forms an anion-selective channel.
Pflügers Archiv : European journal of physiology 2012;463(4):585-92.
2011: B Jelassi; A Chantôme; F Alcaraz-Pérez; Alberto Baroja-Mazo; M L Cayuela; Pablo Pelegrin; Annmarie Surprenant; Sébastien Roger
P2X(7) receptor activation enhances SK3 channels- and cystein cathepsin-dependent cancer cells invasiveness.
Oncogene 2011;30(18):2108-22.
2010: Gloria Lopez-Castejon; Jill Theaker; Pablo Pelegrin; Andrew D Clifton; Martin Braddock; Annmarie Surprenant
P2X(7) receptor-mediated release of cathepsins from macrophages is a cytokine-independent mechanism potentially involved in joint diseases.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(4):2611-9.
2010: Sébastien Roger; Ludovic Gillet; Alberto Baroja-Mazo; Annmarie Surprenant; Pablo Pelegrin
C-terminal calmodulin-binding motif differentially controls human and rat P2X7 receptor current facilitation.
The Journal of biological chemistry 2010;285(23):17514-24.
2010: Sébastien Roger; Zhu-Zhong Mei; Jocelyn M Baldwin; Li Dong; Helen Bradley; Stephen A Baldwin; Annmarie Surprenant; Lin-Hua Jiang
Single nucleotide polymorphisms that were identified in affective mood disorders affect ATP-activated P2X7 receptor functions.
Journal of psychiatric research 2010;44(6):347-55.
2009: Gevdeep Bhabra; Aman Sood; Brenton Fisher; Laura Cartwright; Margaret Saunders; William Howard Evans; Annmarie Surprenant; Gloria Lopez-Castejon; Stephen Mann; Sean A Davis; Lauren A Hails; Eileen Ingham; Paul Verkade; Jon Lane; Kate Heesom; Roger Newson; C Patrick Case
Nanoparticles can cause DNA damage across a cellular barrier.
Nature nanotechnology 2009;4(12):876-83.
2009: Pablo Pelegrin; Annmarie Surprenant
Dynamics of macrophage polarization reveal new mechanism to inhibit IL-1beta release through pyrophosphates.
The EMBO journal 2009;28(14):2114-27.
2009: Pablo Pelegrin; Annmarie Surprenant
The P2X(7) receptor-pannexin connection to dye uptake and IL-1beta release.
Purinergic signalling 2009;5(2):129-37.
2009: Leanne Stokes; Annmarie Surprenant
Dynamic regulation of the P2X4 receptor in alveolar macrophages by phagocytosis and classical activation.
European journal of immunology 2009;39(4):986-95.
2009: Weihong Ma; Hui Hui; Pablo Pelegrin; Annmarie Surprenant
Pharmacological characterization of pannexin-1 currents expressed in mammalian cells.
The Journal of pharmacology and experimental therapeutics 2009;328(2):409-18.
2009: X Liu; W Ma; Annmarie Surprenant; Lin-Hua Jiang
Identification of the amino acid residues in the extracellular domain of rat P2X(7) receptor involved in functional inhibition by acidic pH.
British journal of pharmacology 2009;156(1):135-42.
2009: Annmarie Surprenant; R Alan North
Signaling at purinergic P2X receptors.
Annual review of physiology 2009;71():333-59.
2008: Sébastien Roger; Pablo Pelegrin; Annmarie Surprenant
Facilitation of P2X7 receptor currents and membrane blebbing via constitutive and dynamic calmodulin binding.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(25):6393-401.
2008: Pablo Pelegrin; Consuelo Barroso-Gutierrez; Annmarie Surprenant
P2X7 receptor differentially couples to distinct release pathways for IL-1beta in mouse macrophage.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(11):7147-57.
2008: Katia Varani; Annmarie Surprenant; Fabrizio Vincenzi; Alice Tosi; Stefania Gessi; Stefania Merighi; Pier Andrea Borea
Binding thermodynamic characterization of human P2X1 and P2X3 purinergic receptors.
Biochemical pharmacology 2008;75(5):1198-208.
2008: Xing Liu; Annmarie Surprenant; Hong-Ju Mao; Sebastien Roger; Rong Xia; Helen Bradley; Lin-Hua Jiang
Identification of key residues coordinating functional inhibition of P2X7 receptors by zinc and copper.
Molecular pharmacology 2008;73(1):252-9.
2007: Kathryn R Vaughan; Leanne Stokes; Lynne R Prince; Helen M Marriott; Sabine Meis; Matthias U Kassack; Colin D Bingle; Ian Sabroe; Annmarie Surprenant; Moira K B Whyte
Inhibition of neutrophil apoptosis by ATP is mediated by the P2Y11 receptor.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(12):8544-53.
2007: Leanne Stokes; Annmarie Surprenant
Purinergic P2Y2 receptors induce increased MCP-1/CCL2 synthesis and release from rat alveolar and peritoneal macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(9):6016-23.
2007: Heather Wilson; R W Varcoe; Leanne Stokes; K L Holland; Sheila E Francis; Steven K Dower; Annmarie Surprenant; David C Crossman
P2X receptor characterization and IL-1/IL-1Ra release from human endothelial cells.
British journal of pharmacology 2007;151(1):115-27.
2007: Annmarie Surprenant
Pain TRP-ed up by PARs.
The Journal of physiology 2007;578(Pt 3):631.
2007: Gloria López-Castejón; Mark T Young; José Meseguer; Annmarie Surprenant; Victoriano Mulero
Characterization of ATP-gated P2X7 receptors in fish provides new insights into the mechanism of release of the leaderless cytokine interleukin-1 beta.
Molecular immunology 2007;44(6):1286-99.
2007: Pablo Pelegrin; Annmarie Surprenant
Pannexin-1 couples to maitotoxin- and nigericin-induced interleukin-1beta release through a dye uptake-independent pathway.
The Journal of biological chemistry 2007;282(4):2386-94.
2007: Mark T Young; Pablo Pelegrin; Annmarie Surprenant
Amino acid residues in the P2X7 receptor that mediate differential sensitivity to ATP and BzATP.
Molecular pharmacology 2007;71(1):92-100.
2006: Leanne Stokes; Lin-Hua Jiang; Lilian Alcaraz; Janice Bent; K Bowers; Fagura Malbinder; Mark Furber; Mike Mortimore; M Lawson; J Theaker; C Laurent; Martin Braddock; Annmarie Surprenant
Characterization of a selective and potent antagonist of human P2X(7) receptors, AZ11645373.
British journal of pharmacology 2006;149(7):880-7.
2006: Pablo Pelegrin; Annmarie Surprenant
Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor.
The EMBO journal 2006;25(21):5071-82.
2006: Mark T Young; Pablo Pelegrin; Annmarie Surprenant
Identification of Thr283 as a key determinant of P2X7 receptor function.
British journal of pharmacology 2006;149(3):261-8.
2006: William J Wilkinson; Lin-Hua Jiang; Annmarie Surprenant; R Alan North
Role of ectodomain lysines in the subunits of the heteromeric P2X2/3 receptor.
Molecular pharmacology 2006;70(4):1159-63.
2005: Lin-Hua Jiang; Francois Rassendren; Amanda Mackenzie; Yi-Hong Zhang; Annmarie Surprenant; R Alan North
N-methyl-D-glucamine and propidium dyes utilize different permeation pathways at rat P2X(7) receptors.
American journal of physiology. Cell physiology 2005;289(5):C1295-302.
2005: Amanda B Mackenzie; Mark T Young; Elena Adinolfi; Annmarie Surprenant
Pseudoapoptosis induced by brief activation of ATP-gated P2X7 receptors.
The Journal of biological chemistry 2005;280(40):33968-76.
2005: James I Elliott; Annmarie Surprenant; Federica M Marelli-Berg; Joanne C Cooper; Robin Cassady-Cain; Carol Wooding; Kenneth J Linton; Denis R Alexander; Christopher F Higgins
Membrane phosphatidylserine distribution as a non-apoptotic signalling mechanism in lymphocytes.
Nature cell biology 2005;7(8):808-16.
2004: Joan A Sim; Mark T Young; Hye-Youn Sung; R Alan North; Annmarie Surprenant
Reanalysis of P2X7 receptor expression in rodent brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(28):6307-14.
2003: Lin-Hua Jiang; Miran Kim; Valeria Spelta; Xuenong Bo; Annmarie Surprenant; R Alan North
Subunit arrangement in P2X receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(26):8903-10.
2003: Jonathan W Bowler; R Jayne Bailey; R Alan North; Annmarie Surprenant
P2X4, P2Y1 and P2Y2 receptors on rat alveolar macrophages.
British journal of pharmacology 2003;140(3):567-75.
2003: Elena Adinolfi; Miran Kim; Mark T Young; Francesco Di Virgilio; Annmarie Surprenant
Tyrosine phosphorylation of HSP90 within the P2X7 receptor complex negatively regulates P2X7 receptors.
The Journal of biological chemistry 2003;278(39):37344-51.
2003: Xuenong Bo; Lin-Hua Jiang; Heather Wilson; Miran Kim; Geoffrey Burnstock; Annmarie Surprenant; R Alan North
Pharmacological and biophysical properties of the human P2X5 receptor.
Molecular pharmacology 2003;63(6):1407-16.
2003: Brice Campo; Annmarie Surprenant; R Alan North
Sustained depolarization and ADP-ribose activate a common ionic current in rat peritoneal macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(3):1167-73.
2003: Valeria Spelta; Lin-Hua Jiang; R Jayne Bailey; Annmarie Surprenant; R Alan North
Interaction between cysteines introduced into each transmembrane domain of the rat P2X2 receptor.
British journal of pharmacology 2003;138(1):131-6.
2002: Heather Wilson; Stuart A Wilson; Annmarie Surprenant; R Alan North
Epithelial membrane proteins induce membrane blebbing and interact with the P2X7 receptor C terminus.
The Journal of biological chemistry 2002;277(37):34017-23.
2002: Valeria Spelta; Lin-Hua Jiang; Annmarie Surprenant; R Alan North
Kinetics of antagonist actions at rat P2X2/3 heteromeric receptors.
British journal of pharmacology 2002;135(6):1524-30.
2001: Miran Kim; Lin-Hua Jiang; Heather Wilson; R Alan North; Annmarie Surprenant
Proteomic and functional evidence for a P2X7 receptor signalling complex.
The EMBO journal 2001;20(22):6347-58.
2001: A MacKenzie; Heather Wilson; Endre Kiss-Toth; Steven K Dower; R Alan North; Annmarie Surprenant
Rapid secretion of interleukin-1beta by microvesicle shedding.
Immunity 2001;15(5):825-35.
2001: Miran Kim; Valeria Spelta; J Sim; R Alan North; Annmarie Surprenant
Differential assembly of rat purinergic P2X7 receptor in immune cells of the brain and periphery.
The Journal of biological chemistry 2001;276(26):23262-7.
2001: Lin-Hua Jiang; Francois Rassendren; Valeria Spelta; Annmarie Surprenant; R Alan North
Amino acid residues involved in gating identified in the first membrane-spanning domain of the rat P2X(2) receptor.
The Journal of biological chemistry 2001;276(18):14902-8.
2000: Lin-Hua Jiang; Francois Rassendren; Annmarie Surprenant; R Alan North
Identification of amino acid residues contributing to the ATP-binding site of a purinergic P2X receptor.
The Journal of biological chemistry 2000;275(44):34190-6.
2000: Annmarie Surprenant; David A Schneider; Heather Wilson; James J Galligan; R Alan North
Functional properties of heteromeric P2X(1/5) receptors expressed in HEK cells and excitatory junction potentials in guinea-pig submucosal arterioles.
Journal of the autonomic nervous system 2000;81(1-3):249-63.
2000: Lin-Hua Jiang; Amanda B Mackenzie; R Alan North; Annmarie Surprenant
Brilliant blue G selectively blocks ATP-gated rat P2X(7) receptors.
Molecular pharmacology 2000;58(1):82-8.
1999: R Stoop; S Thomas; Francois Rassendren; E Kawashima; Gary N Buell; Annmarie Surprenant; R Alan North
Contribution of individual subunits to the multimeric P2X(2) receptor: estimates based on methanethiosulfonate block at T336C.
Molecular pharmacology 1999;56(5):973-81.
1999: C Virginio; Amanda Mackenzie; R Alan North; Annmarie Surprenant
Kinetics of cell lysis, dye uptake and permeability changes in cells expressing the rat P2X7 receptor.
The Journal of physiology 1999;519 Pt 2():335-46.
1999: Amanda B Mackenzie; Annmarie Surprenant; R Alan North
Functional and molecular diversity of purinergic ion channel receptors.
Annals of the New York Academy of Sciences 1999;868():716-29.
1999: C Virginio; Amanda Mackenzie; Francois Rassendren; R Alan North; Annmarie Surprenant
Pore dilation of neuronal P2X receptor channels.
Nature neuroscience 1999;2(4):315-21.
1998: Lucy Vulchanova; Maureen S Riedl; SJ Shuster; Laura S Stone; Kenneth Hargreaves; Gary N Buell; Annmarie Surprenant; R Alan North; Robert Elde
P2X3 is expressed by DRG neurons that terminate in inner lamina II.
The European journal of neuroscience 1998;10(11):3470-8.
1998: BD Humphreys; C Virginio; Annmarie Surprenant; J Rice; George R Dubyak
Isoquinolines as antagonists of the P2X7 nucleotide receptor: high selectivity for the human versus rat receptor homologues.
Molecular pharmacology 1998;54(1):22-32.
1998: C Virginio; R Alan North; Annmarie Surprenant
Calcium permeability and block at homomeric and heteromeric P2X2 and P2X3 receptors, and P2X receptors in rat nodose neurones.
The Journal of physiology 1998;510 ( Pt 1)():27-35.
1998: A Newbolt; R Stoop; C Virginio; Annmarie Surprenant; R Alan North; Gary N Buell; Francois Rassendren
Membrane topology of an ATP-gated ion channel (P2X receptor).
The Journal of biological chemistry 1998;273(24):15177-82.
1998: C Virginio; G Robertson; Annmarie Surprenant; R Alan North
Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X1, P2X3, and heteromeric P2X2/3 receptors.
Molecular pharmacology 1998;53(6):969-73.
1998: S Thomas; C Virginio; R Alan North; Annmarie Surprenant
The antagonist trinitrophenyl-ATP reveals co-existence of distinct P2X receptor channels in rat nodose neurones.
The Journal of physiology 1998;509 ( Pt 2)():411-7.
1998: E Kawashima; D Estoppey; C Virginio; D Fahmi; S Rees; Annmarie Surprenant; R Alan North
A novel and efficient method for the stable expression of heteromeric ion channels in mammalian cells.
Receptors & channels 1998;5(2):53-60.
1997: R Stoop; Annmarie Surprenant; R Alan North
Different sensitivities to pH of ATP-induced currents at four cloned P2X receptors.
Journal of neurophysiology 1997;78(4):1837-40.
1997: C Virginio; D Church; R Alan North; Annmarie Surprenant
Effects of divalent cations, protons and calmidazolium at the rat P2X7 receptor.
Neuropharmacology 1997;36(9):1285-94.
1997: Lucy Vulchanova; Maureen S Riedl; SJ Shuster; Gary N Buell; Annmarie Surprenant; R Alan North; Robert Elde
Immunohistochemical study of the P2X2 and P2X3 receptor subunits in rat and monkey sensory neurons and their central terminals.
Neuropharmacology 1997;36(9):1229-42.
1997: K M Radford; C Virginio; Annmarie Surprenant; R Alan North; E Kawashima
Baculovirus expression provides direct evidence for heteromeric assembly of P2X2 and P2X3 receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(17):6529-33.
1997: Francois Rassendren; Gary N Buell; A Newbolt; R Alan North; Annmarie Surprenant
Identification of amino acid residues contributing to the pore of a P2X receptor.
The EMBO journal 1997;16(12):3446-54.
1997: Francois Rassendren; Gary N Buell; C Virginio; G Collo; R Alan North; Annmarie Surprenant
The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA.
The Journal of biological chemistry 1997;272(9):5482-6.
1996: R J Evans; C Lewis; C Virginio; K Lundstrom; Gary N Buell; Annmarie Surprenant; R Alan North
Ionic permeability of, and divalent cation effects on, two ATP-gated cation channels (P2X receptors) expressed in mammalian cells.
The Journal of physiology 1996;497 ( Pt 2)():413-22.
1996: Anton D Michel; K Lundström; Gary N Buell; Annmarie Surprenant; S Valera; Patrick P A Humphrey
A comparison of the binding characteristics of recombinant P2X1 and P2X2 purinoceptors.
British journal of pharmacology 1996;118(7):1806-12.
1996: Lucy Vulchanova; Ulf Arvidsson; Maureen S Riedl; J Wang; Gary N Buell; Annmarie Surprenant; R Alan North; Robert Elde
Differential distribution of two ATP-gated channels (P2X receptors) determined by immunocytochemistry.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(15):8063-7.
1996: Annmarie Surprenant; Francois Rassendren; E Kawashima; R Alan North; Gary N Buell
The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7).
Science (New York, N.Y.) 1996;272(5262):735-8.
1996: G Collo; R Alan North; E Kawashima; E Merlo-Pich; S Neidhart; Annmarie Surprenant; Gary N Buell
Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(8):2495-507.
1996: Gary N Buell; Anton D Michel; C Lewis; G Collo; Patrick P A Humphrey; Annmarie Surprenant
P2X1 receptor activation in HL60 cells.
Blood 1996;87(7):2659-64.
1996: Anton D Michel; K Lundström; Gary N Buell; Annmarie Surprenant; S Valera; Patrick P A Humphrey
The binding characteristics of a human bladder recombinant P2X purinoceptor, labelled with [3H]-alpha beta meATP, [35S]-ATP gamma S or [33P]-ATP.
British journal of pharmacology 1996;117(6):1254-60.
1996: Gary N Buell; C Lewis; G Collo; R Alan North; Annmarie Surprenant
An antagonist-insensitive P2X receptor expressed in epithelia and brain.
The EMBO journal 1996;15(1):55-62.
1995: Patrick P A Humphrey; G Buell; I Kennedy; B S Khakh; Anton D Michel; Annmarie Surprenant; D J Trezise
New insights on P2X purinoceptors.
Naunyn-Schmiedeberg's archives of pharmacology 1995;352(6):585-96.
1995: C Lewis; S Neidhart; C Holy; R Alan North; Gary N Buell; Annmarie Surprenant
Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons.
Nature 1995;377(6548):432-5.
1995: R J Evans; C Lewis; Gary N Buell; S Valera; R Alan North; Annmarie Surprenant
Pharmacological characterization of heterologously expressed ATP-gated cation channels (P2x purinoceptors).
Molecular pharmacology 1995;48(2):178-83.
1995: D J Trezise; Anton D Michel; C B Grahames; B S Khakh; Annmarie Surprenant; Patrick P A Humphrey
The selective P2X purinoceptor agonist, beta,gamma-methylene-L-adenosine 5'-triphosphate, discriminates between smooth muscle and neuronal P2X purinoceptors.
Naunyn-Schmiedeberg's archives of pharmacology 1995;351(6):603-9.
1995: B S Khakh; Annmarie Surprenant; Patrick P A Humphrey
A study on P2X purinoceptors mediating the electrophysiological and contractile effects of purine nucleotides in rat vas deferens.
British journal of pharmacology 1995;115(1):177-85.
1995: Annmarie Surprenant; Gary N Buell; R Alan North
P2X receptors bring new structure to ligand-gated ion channels.
Trends in neurosciences 1995;18(5):224-9.
1995: B S Khakh; Patrick P A Humphrey; Annmarie Surprenant
Electrophysiological properties of P2X-purinoceptors in rat superior cervical, nodose and guinea-pig coeliac neurones.
The Journal of physiology 1995;484 ( Pt 2)():385-95.
1994: S Valera; N Hussy; R J Evans; N Adami; R Alan North; Annmarie Surprenant; Gary N Buell
A new class of ligand-gated ion channel defined by P2x receptor for extracellular ATP.
Nature 1994;371(6497):516-9.