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Joel Sussman

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

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Torpedo

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Procedures

X-Ray Crystallography

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Co-Publications
Name
83
Silman, Israel
35
Harel, Michal
15
Greenblatt, Harry
12
Prilusky, Jaime
11
Toker, Lilly
10
Kryger, G
10
Frolow, Felix
10
Brumshtein, Boris
9
Dvir, Hay
9
Weik, Martin
8
Futerman, Anthony
8
Ravelli, Raimond
8
Raves, Maria
7
Zeev-Ben-Mordehai, Tzviya
6
Wong, Dawn

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Publications

TOP 3
Zeev-Ben-Mordehai Tzviya; Mylonas Efstratios; Paz Aviv; Peleg Yoav; Toker Lilly; Silman Israel; Svergun Dmitri I; Sussman Joel L
The quaternary structure of amalgam, a Drosophila neuronal adhesion protein, explains its dual adhesion properties.
Khersonsky Olga; Rosenblat Mira; Toker Lilly; Yacobson Shiri; Hugenmatter Adrian; Silman Israel; Sussman Joel L; Aviram Michael; Tawfik Dan S
Directed evolution of serum paraoxonase PON3 by family shuffling and ancestor/consensus mutagenesis, and its biochemical characterization.
Brumshtein Boris; Aguilar-Moncayo Matilde; García-Moreno M Isabel; Ortiz Mellet Carmen; García Fernández José M; Silman Israel; Shaaltiel Yoseph; Aviezer David; Sussman Joel L; Futerman Anthony H
6-Amino-6-deoxy-5,6-di-N-(N'-octyliminomethylidene)nojirimycin: synthesis, biological evaluation, and crystal structure in complex with acid beta-glucosidase.

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All Publications

2009: Zeev-Ben-Mordehai Tzviya; Mylonas Efstratios; Paz Aviv; Peleg Yoav; Toker Lilly; Silman Israel; Svergun Dmitri I; Sussman Joel L
The quaternary structure of amalgam, a Drosophila neuronal adhesion protein, explains its dual adhesion properties.
Biophysical journal 2009;97(8):2316-26.
2009: Khersonsky Olga; Rosenblat Mira; Toker Lilly; Yacobson Shiri; Hugenmatter Adrian; Silman Israel; Sussman Joel L; Aviram Michael; Tawfik Dan S
Directed evolution of serum paraoxonase PON3 by family shuffling and ancestor/consensus mutagenesis, and its biochemical characterization.
Biochemistry 2009;48(28):6644-54.
2009: Brumshtein Boris; Aguilar-Moncayo Matilde; García-Moreno M Isabel; Ortiz Mellet Carmen; García Fernández José M; Silman Israel; Shaaltiel Yoseph; Aviezer David; Sussman Joel L; Futerman Anthony H
6-Amino-6-deoxy-5,6-di-N-(N'-octyliminomethylidene)nojirimycin: synthesis, biological evaluation, and crystal structure in complex with acid beta-glucosidase.
Chembiochem : a European journal of chemical biology 2009;10(9):1480-5.
2009: Paz Aviv; Xie Qiong; Greenblatt Harry M; Fu Wei; Tang Yun; Silman Israel; Qiu Zhuibai; Sussman Joel L
The crystal structure of a complex of acetylcholinesterase with a bis-(-)-nor-meptazinol derivative reveals disruption of the catalytic triad.
Journal of medicinal chemistry 2009;52(8):2543-9.
2009: Hodis Eran; Sussman Joel L
An encyclopedic effort to make 3D structures easier to understand.
Trends in biochemical sciences 2009;34(3):100-1.
2009: Zeev-Ben-Mordehai Tzviya; Paz Aviv; Peleg Yoav; Toker Lilly; Wolf Sharon G; Rydberg Edwin H; Sussman Joel L; Silman Israel
Amalgam, an axon guidance Drosophila adhesion protein belonging to the immunoglobulin superfamily: over-expression, purification and biophysical characterization.
Protein expression and purification 2009;63(2):147-57.
2009: Noivirt-Brik Orly; Prilusky Jaime; Sussman Joel L
Assessment of disorder predictions in CASP8.
Proteins 2009;77 Suppl 9():210-6.
2009: Ben-David Moshe; Noivirt-Brik Orly; Paz Aviv; Prilusky Jaime; Sussman Joel L; Levy Yaakov
Assessment of CASP8 structure predictions for template free targets.
Proteins 2009;77 Suppl 9():50-65.
2008: Kacher Yaacov; Brumshtein Boris; Boldin-Adamsky Swetlana; Toker Lilly; Shainskaya Alla; Silman Israel; Sussman Joel L; Futerman Anthony H
Acid beta-glucosidase: insights from structural analysis and relevance to Gaucher disease therapy.
Biological chemistry 2008;389(11):1361-9.
2008: Silman Israel; Sussman Joel L
Acetylcholinesterase: how is structure related to function?
Chemico-biological interactions 2008;175(1-3):3-10.
2008: Xu Yechun; Colletier Jacques-Philippe; Weik Martin; Jiang Hualiang; Moult John; Silman Israel; Sussman Joel L
Flexibility of aromatic residues in the active-site gorge of acetylcholinesterase: X-ray versus molecular dynamics.
Biophysical journal 2008;95(5):2500-11.
2008: Colletier Jacques-Philippe; Bourgeois Dominique; Sanson Benoît; Fournier Didier; Sussman Joel L; Silman Israel; Weik Martin
Shoot-and-Trap: use of specific x-ray damage to study structural protein dynamics by temperature-controlled cryo-crystallography.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(33):11742-7.
2008: Paz Aviv; Zeev-Ben-Mordehai Tzviya; Lundqvist Martin; Sherman Eilon; Mylonas Efstratios; Weiner Lev; Haran Gilad; Svergun Dmitri I; Mulder Frans A A; Sussman Joel L; Silman Israel
Biophysical characterization of the unstructured cytoplasmic domain of the human neuronal adhesion protein neuroligin 3.
Biophysical journal 2008;95(4):1928-44.
2008: Harel Michal; Sonoda Leilani K; Silman Israel; Sussman Joel L; Rosenberry Terrone L
Crystal structure of thioflavin T bound to the peripheral site of Torpedo californica acetylcholinesterase reveals how thioflavin T acts as a sensitive fluorescent reporter of ligand binding to the acylation site.
Journal of the American Chemical Society 2008;130(25):7856-61.
2008: Xu Yechun; Colletier Jacques Ph; Jiang Hualiang; Silman Israel; Sussman Joel L; Weik Martin
Induced-fit or preexisting equilibrium dynamics? Lessons from protein crystallography and MD simulations on acetylcholinesterase and implications for structure-based drug design.
Protein science : a publication of the Protein Society 2008;17(4):601-5.
2008: Tsvetkov Peter; Asher Gad; Paz Aviv; Reuven Nina; Sussman Joel L; Silman Israel; Shaul Yosef
Operational definition of intrinsically unstructured protein sequences based on susceptibility to the 20S proteasome.
Proteins 2008;70(4):1357-66.
2008: Hodis Eran; Prilusky Jaime; Martz Eric; Silman Israel; Moult John; Sussman Joel L
Proteopedia - a scientific 'wiki' bridging the rift between three-dimensional structure and function of biomacromolecules.
Genome biology 2008;9(8):R121.
2008: Meged Ran; Dym Orly; Sussman Joel L
High throughput pH optimization of protein crystallization.
Methods in molecular biology (Clifton, N.J.) 2008;426():411-8.
2007: Colletier Jacques-Philippe; Royant Antoine; Specht Alexandre; Sanson Benoît; Nachon Florian; Masson Patrick; Zaccai Giuseppe; Sussman Joel L; Goeldner Maurice; Silman Israel; Bourgeois Dominique; Weik Martin
Use of a 'caged' analogue to study the traffic of choline within acetylcholinesterase by kinetic crystallography.
Acta crystallographica. Section D, Biological crystallography 2007;63(Pt 11):1115-28.
2007: Harel Michal; Brumshtein Boris; Meged Ran; Dvir Hay; Ravelli Raimond B G; McCarthy Andrew; Toker Lilly; Silman Israel; Sussman Joel L
3-D structure of serum paraoxonase 1 sheds light on its activity, stability, solubility and crystallizability.
Arhiv za higijenu rada i toksikologiju 2007;58(3):347-53.
2007: Brumshtein Boris; Greenblatt Harry M; Butters Terry D; Shaaltiel Yoseph; Aviezer David; Silman Israel; Futerman Anthony H; Sussman Joel L
Crystal structures of complexes of N-butyl- and N-nonyl-deoxynojirimycin bound to acid beta-glucosidase: insights into the mechanism of chemical chaperone action in Gaucher disease.
The Journal of biological chemistry 2007;282(39):29052-8.
2007: Shaaltiel Yoseph; Bartfeld Daniel; Hashmueli Sharon; Baum Gideon; Brill-Almon Einat; Galili Gad; Dym Orly; Boldin-Adamsky Swetlana A; Silman Israel; Sussman Joel L; Futerman Anthony H; Aviezer David
Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement therapy of Gaucher's disease using a plant cell system.
Plant biotechnology journal 2007;5(5):579-90.
2007: Felder Clifford E; Prilusky Jaime; Silman Israel; Sussman Joel L
A server and database for dipole moments of proteins.
Nucleic acids research 2007;35(Web Server issue):W512-21.
2007: Hodis Eran; Schreiber Gideon; Rother Kristian; Sussman Joel L
eMovie: a storyboard-based tool for making molecular movies.
Trends in biochemical sciences 2007;32(5):199-204.
2007: Haviv H; Wong D M; Silman I; Sussman J L
Bivalent ligands derived from Huperzine A as acetylcholinesterase inhibitors.
Current topics in medicinal chemistry 2007;7(4):375-87.
2006: Brumshtein Boris; Wormald Mark R; Silman Israel; Futerman Anthony H; Sussman Joel L
Structural comparison of differently glycosylated forms of acid-beta-glucosidase, the defective enzyme in Gaucher disease.
Acta crystallographica. Section D, Biological crystallography 2006;62(Pt 12):1458-65.
2006: Esnouf Robert M; Hamer R; Sussman J L; Silman I; Trudgian D; Yang Z-R; Prilusky Jaime
Honing the in silico toolkit for detecting protein disorder.
Acta crystallographica. Section D, Biological crystallography 2006;62(Pt 10):1260-6.
2006: Romier Christophe; Ben Jelloul Marouane; Albeck Shira; Buchwald Gretel; Busso Didier; Celie Patrick H N; Christodoulou Evangelos; De Marco Valeria; van Gerwen Suzan; Knipscheer Puck; Lebbink Joyce H; Notenboom Valerie; Poterszman Arnaud; Rochel Natacha; Cohen Serge X; Unger Tamar; Sussman Joel L; Moras Dino; Sixma Titia K; Perrakis Anastassis
Co-expression of protein complexes in prokaryotic and eukaryotic hosts: experimental procedures, database tracking and case studies.
Acta crystallographica. Section D, Biological crystallography 2006;62(Pt 10):1232-42.
2006: Banci L; Bertini I; Cusack S; de Jong R N; Heinemann U; Jones E Y; Kozielski F; Maskos K; Messerschmidt A; Owens R; Perrakis A; Poterszman A; Schneider G; Siebold C; Silman I; Sixma T; Stewart-Jones G; Sussman J L; Thierry J C; Moras Dino
First steps towards effective methods in exploiting high-throughput technologies for the determination of human protein structures of high biomedical value.
Acta crystallographica. Section D, Biological crystallography 2006;62(Pt 10):1208-17.
2006: Berry Ian M; Dym O; Esnouf R M; Harlos K; Meged R; Perrakis A; Sussman J L; Walter T S; Wilson J; Messerschmidt Albrecht
SPINE high-throughput crystallization, crystal imaging and recognition techniques: current state, performance analysis, new technologies and future aspects.
Acta crystallographica. Section D, Biological crystallography 2006;62(Pt 10):1137-49.
2006: Aricescu A R; Assenberg R; Bill R M; Busso D; Chang V T; Davis S J; Dubrovsky A; Gustafsson L; Hedfalk K; Heinemann U; Jones I M; Ksiazek D; Lang C; Maskos K; Messerschmidt A; Macieira S; Peleg Y; Perrakis A; Poterszman A; Schneider G; Sixma T K; Sussman J L; Sutton G; Tarboureich N; Zeev-Ben-Mordehai T; Jones E Yvonne
Eukaryotic expression: developments for structural proteomics.
Acta crystallographica. Section D, Biological crystallography 2006;62(Pt 10):1114-24.
2006: Rydberg Edwin H; Brumshtein Boris; Greenblatt Harry M; Wong Dawn M; Shaya David; Williams Larry D; Carlier Paul R; Pang Yuan-Ping; Silman Israel; Sussman Joel L
Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge.
Journal of medicinal chemistry 2006;49(18):5491-500.
2006: Colletier Jacques-Philippe; Fournier Didier; Greenblatt Harry M; Stojan Jure; Sussman Joel L; Zaccai Giuseppe; Silman Israel; Weik Martin
Structural insights into substrate traffic and inhibition in acetylcholinesterase.
The EMBO journal 2006;25(12):2746-56.
2005: Harel Michal; Hyatt Janice L; Brumshtein Boris; Morton Christopher L; Wadkins Randy M; Silman Israel; Sussman Joel L; Potter Philip M
The 3D structure of the anticancer prodrug CPT-11 with Torpedo californica acetylcholinesterase rationalizes its inhibitory action on AChE and its hydrolysis by butyrylcholinesterase and carboxylesterase.
Chemico-biological interactions 2005;157-158():153-7.
2005: Hyatt Janice L; Tsurkan Lyudmila; Morton Christopher L; Yoon Kyoung J P; Harel Michal; Brumshtein Boris; Silman Israel; Sussman Joel L; Wadkins Randy M; Potter Philip M
Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11.
Chemico-biological interactions 2005;157-158():247-52.
2005: Newman Janet; Egan David; Walter Thomas S; Meged Ran; Berry Ian; Ben Jelloul Marouane; Sussman Joel L; Stuart David I; Perrakis Anastassis
Towards rationalization of crystallization screening for small- to medium-sized academic laboratories: the PACT/JCSG+ strategy.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 10):1426-31.
2005: Albeck Shira; Burstein Yigal; Dym Orly; Jacobovitch Yossi; Levi Nurit; Meged Ran; Michael Yigal; Peleg Yoav; Prilusky Jaime; Schreiber Gideon; Silman Israel; Unger Tamar; Sussman Joel L
Three-dimensional structure determination of proteins related to human health in their functional context at The Israel Structural Proteomics Center (ISPC). This paper was presented at ICCBM10.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 10):1364-72.
2005: Haviv Haim; Wong Dawn M; Greenblatt Harry M; Carlier Paul R; Pang Yuan-Ping; Silman Israel; Sussman Joel L
Crystal packing mediates enantioselective ligand recognition at the peripheral site of acetylcholinesterase.
Journal of the American Chemical Society 2005;127(31):11029-36.
2005: Prilusky Jaime; Felder Clifford E; Zeev-Ben-Mordehai Tzviya; Rydberg Edwin H; Man Orna; Beckmann Jacques S; Silman Israel; Sussman Joel L
FoldIndex: a simple tool to predict whether a given protein sequence is intrinsically unfolded.
Bioinformatics (Oxford, England) 2005;21(16):3435-8.
2005: Prilusky Jaime; Oueillet Eric; Ulryck Nathalie; Pajon Anne; Bernauer Julie; Krimm Isabelle; Quevillon-Cheruel Sophie; Leulliot Nicolas; Graille Marc; Liger Dominique; Trésaugues Lionel; Sussman Joel L; Janin Joël; van Tilbeurgh Herman; Poupon Anne
HalX: an open-source LIMS (Laboratory Information Management System) for small- to large-scale laboratories.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 6):671-8.
2005: Silman Israel; Sussman Joel L
Acetylcholinesterase: 'classical' and 'non-classical' functions and pharmacology.
Current opinion in pharmacology 2005;5(3):293-302.
2005: Premkumar Lakshmanane; Sawkar Anu R; Boldin-Adamsky Swetlana; Toker Lilly; Silman Israel; Kelly Jeffery W; Futerman Anthony H; Sussman Joel L
X-ray structure of human acid-beta-glucosidase covalently bound to conduritol-B-epoxide. Implications for Gaucher disease.
The Journal of biological chemistry 2005;280(25):23815-9.
2005: Harel Michal; Hyatt Janice L; Brumshtein Boris; Morton Christopher L; Yoon Kyoung Jin P; Wadkins Randy M; Silman Israel; Sussman Joel L; Potter Philip M
The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action.
Molecular pharmacology 2005;67(6):1874-81.
2005: Premkumar Lakshmanane; Greenblatt Harry M; Bageshwar Umesh K; Savchenko Tatyana; Gokhman Irena; Sussman Joel L; Zamir Ada
Three-dimensional structure of a halotolerant algal carbonic anhydrase predicts halotolerance of a mammalian homolog.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(21):7493-8.
2005: Hasin Yehudit; Avidan Nili; Bercovich Dani; Korczyn Amos D; Silman Israel; Beckmann Jacques S; Sussman Joel L
Analysis of genetic polymorphisms in acetylcholinesterase as reflected in different populations.
Current Alzheimer research 2005;2(2):207-18.
2005: Jaakola Veli-Pekka; Prilusky Jaime; Sussman Joel L; Goldman Adrian
G protein-coupled receptors show unusual patterns of intrinsic unfolding.
Protein engineering, design & selection : PEDS 2005;18(2):103-10.
2004: Greenblatt Harry M; Guillou Catherine; Guénard Daniel; Argaman Anat; Botti Simone; Badet Bernard; Thal Claude; Silman Israel; Sussman Joel L
The complex of a bivalent derivative of galanthamine with torpedo acetylcholinesterase displays drastic deformation of the active-site gorge: implications for structure-based drug design.
Journal of the American Chemical Society 2004;126(47):15405-11.
2004: Dvir Hay; Harel Michal; Bon Suzanne; Liu Wang-Qing; Vidal Michel; Garbay Christiane; Sussman Joel L; Massoulié Jean; Silman Israel
The synaptic acetylcholinesterase tetramer assembles around a polyproline II helix.
The EMBO journal 2004;23(22):4394-405.
2004: Hasin Yehudit; Avidan Nili; Bercovich Dani; Korczyn Amos; Silman Israel; Beckmann Jacques S; Sussman Joel L
A paradigm for single nucleotide polymorphism analysis: the case of the acetylcholinesterase gene.
Human mutation 2004;24(5):408-16.
2004: Harel Michal; Aharoni Amir; Gaidukov Leonid; Brumshtein Boris; Khersonsky Olga; Meged Ran; Dvir Hay; Ravelli Raimond B G; McCarthy Andrew; Toker Lilly; Silman Israel; Sussman Joel L; Tawfik Dan S
Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes.
Nature structural & molecular biology 2004;11(5):412-9.
2004: Futerman Anthony H; Sussman Joel L; Horowitz Mia; Silman Israel; Zimran Ari
New directions in the treatment of Gaucher disease.
Trends in pharmacological sciences 2004;25(3):147-51.
2004: Bageshwar Umesh K; Premkumar Lakshmanane; Gokhman Irena; Savchenko Tatyana; Sussman Joel L; Zamir Ada
Natural protein engineering: a uniquely salt-tolerant, but not halophilic, alpha-type carbonic anhydrase from algae proliferating in low- to hyper-saline environments.
Protein engineering, design & selection : PEDS 2004;17(2):191-200.
2004: Pe'er Itsik; Felder Clifford E; Man Orna; Silman Israel; Sussman Joel L; Beckmann Jacques S
Proteomic signatures: amino acid and oligopeptide compositions differentiate among phyla.
Proteins 2004;54(1):20-40.
2003: Zeev-Ben-Mordehai Tzviya; Rydberg Edwin H; Solomon Ariel; Toker Lilly; Auld Vanessa J; Silman Israel; Botti Simone; Sussman Joel L
The intracellular domain of the Drosophila cholinesterase-like neural adhesion protein, gliotactin, is natively unfolded.
Proteins 2003;53(3):758-67.
2003: Fuchs Sara; Kasher Roni; Balass Moshe; Scherf Tali; Harel Mchal; Fridkin Mati; Sussman Joel L; Katchalski-Katzir Ephraim
The binding site of acetylcholine receptor: from synthetic peptides to solution and crystal structure.
Annals of the New York Academy of Sciences 2003;998():93-100.
2003: Dvir Hay; Harel Michal; McCarthy Andrew A; Toker Lilly; Silman Israel; Futerman Anthony H; Sussman Joel L
X-ray structure of human acid-beta-glucosidase, the defective enzyme in Gaucher disease.
EMBO reports 2003;4(7):704-9.
2003: Premkumar Lakshmanane; Greenblatt Harry M; Bageshwar Umesh K; Savchenko Tatyana; Gokhman Irena; Zamir Ada; Sussman Joel L
Identification, cDNA cloning, expression, crystallization and preliminary X-ray analysis of an exceptionally halotolerant carbonic anhydrase from Dunaliella salina.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 6):1084-6.
2003: Premkumar Lakshmanane; Bageshwar Umesh K; Gokhman Irena; Zamir Ada; Sussman Joel L
An unusual halotolerant alpha-type carbonic anhydrase from the alga Dunaliella salina functionally expressed in Escherichia coli.
Protein expression and purification 2003;28(1):151-7.
2003: Zeev-Ben-Mordehai T; Silman I; Sussman J L
Acetylcholinesterase in motion: visualizing conformational changes in crystal structures by a morphing procedure.
Biopolymers 2003;68(3):395-406.
2003: Wong Dawn M; Greenblatt Harry M; Dvir Hay; Carlier Paul R; Han Yi-Fan; Pang Yuan-Ping; Silman Israel; Sussman Joel L
Acetylcholinesterase complexed with bivalent ligands related to huperzine a: experimental evidence for species-dependent protein-ligand complementarity.
Journal of the American Chemical Society 2003;125(2):363-73.
2003: Greenblatt Harry M; Dvir Hay; Silman Israel; Sussman Joel L
Acetylcholinesterase: a multifaceted target for structure-based drug design of anticholinesterase agents for the treatment of Alzheimer's disease.
Journal of molecular neuroscience : MN 2003;20(3):369-83.
2003: Katchalski-Katzir Ephraim; Kasher Roni; Balass Moshe; Scherf Tali; Harel Michal; Fridkin Mati; Sussman Joel L; Fuchs Sara
Design and synthesis of peptides that bind alpha-bungarotoxin with high affinity and mimic the three-dimensional structure of the binding-site of acetylcholine receptor.
Biophysical chemistry 2003;100(1-3):293-305.
2002: Weik Martin; Bergès Jacqueline; Raves Maria L; Gros Piet; McSweeney Sean; Silman Israel; Sussman Joel L; Houée-Levin Chantal; Ravelli Raimond B G
Evidence for the formation of disulfide radicals in protein crystals upon X-ray irradiation.
Journal of synchrotron radiation 2002;9(Pt 6):342-6.
2002: Felder Clifford E; Harel Michal; Silman Israel; Sussman Joel L
Structure of a complex of the potent and specific inhibitor BW284C51 with Torpedo californica acetylcholinesterase.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 10 Pt 2):1765-71.
2002: Dvir H; Jiang H L; Wong D M; Harel M; Chetrit M; He X C; Jin G Y; Yu G L; Tang X C; Silman I; Bai D L; Sussman J L
X-ray structures of Torpedo californica acetylcholinesterase complexed with (+)-huperzine A and (-)-huperzine B: structural evidence for an active site rearrangement.
Biochemistry 2002;41(35):10810-8.
2002: Koellner Gertraud; Steiner Thomas; Millard Charles B; Silman Israel; Sussman Joel L
A neutral molecule in a cation-binding site: specific binding of a PEG-SH to acetylcholinesterase from Torpedo californica.
Journal of molecular biology 2002;320(4):721-5.
2002: Bar-On P; Millard C B; Harel M; Dvir H; Enz A; Sussman J L; Silman I
Kinetic and structural studies on the interaction of cholinesterases with the anti-Alzheimer drug rivastigmine.
Biochemistry 2002;41(11):3555-64.
2002: Dvir H; Wong D M; Harel M; Barril X; Orozco M; Luque F J; Muñoz-Torrero D; Camps P; Rosenberry T L; Silman I; Sussman J L
3D structure of Torpedo californica acetylcholinesterase complexed with huprine X at 2.1 A resolution: kinetic and molecular dynamic correlates.
Biochemistry 2002;41(9):2970-81.
2001: Harel M; Kasher R; Nicolas A; Guss J M; Balass M; Fridkin M; Smit A B; Brejc K; Sixma T K; Katchalski-Katzir E; Sussman J L; Fuchs S
The binding site of acetylcholine receptor as visualized in the X-Ray structure of a complex between alpha-bungarotoxin and a mimotope peptide.
Neuron 2001;32(2):265-75.
2001: Weik M; Ravelli R B; Silman I; Sussman J L; Gros P; Kroon J
Specific protein dynamics near the solvent glass transition assayed by radiation-induced structural changes.
Protein science : a publication of the Protein Society 2001;10(10):1953-61.
2001: Doucet-Personeni C; Bentley P D; Fletcher R J; Kinkaid A; Kryger G; Pirard B; Taylor A; Taylor R; Taylor J; Viner R; Silman I; Sussman J L; Greenblatt H M; Lewis T
A structure-based design approach to the development of novel, reversible AChE inhibitors.
Journal of medicinal chemistry 2001;44(20):3203-15.
2001: Nicolas A; Ferron F; Toker L; Sussman J L; Silman I
Histochemical method for characterization of enzyme crystals: application to crystals of Torpedo californica acetylcholinesterase.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 9):1348-50.
2001: Weik M; Kryger G; Schreurs A M; Bouma B; Silman I; Sussman J L; Gros P; Kroon J
Solvent behaviour in flash-cooled protein crystals at cryogenic temperatures.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 4):566-73.
2000: Kryger G; Harel M; Giles K; Toker L; Velan B; Lazar A; Kronman C; Barak D; Ariel N; Shafferman A; Silman I; Sussman J L
Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 11):1385-94.
2000: Lin D; Manning N O; Jiang J; Abola E E; Stampf D; Prilusky J; Sussman J L
AutoDep: a web-based system for deposition and validation of macromolecular structural -information.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 7):828-41.
2000: Harel M; Kryger G; Rosenberry T L; Mallender W D; Lewis T; Fletcher R J; Guss J M; Silman I; Sussman J L
Three-dimensional structures of Drosophila melanogaster acetylcholinesterase and of its complexes with two potent inhibitors.
Protein science : a publication of the Protein Society 2000;9(6):1063-72.
2000: Koellner G; Kryger G; Millard C B; Silman I; Sussman J L; Steiner T
Active-site gorge and buried water molecules in crystal structures of acetylcholinesterase from Torpedo californica.
Journal of molecular biology 2000;296(2):713-35.
2000: Weik M; Ravelli R B; Kryger G; McSweeney S; Raves M L; Harel M; Gros P; Silman I; Kroon J; Sussman J L
Specific chemical and structural damage to proteins produced by synchrotron radiation.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(2):623-8.
1999: Greenblatt H M; Kryger G; Lewis T; Silman I; Sussman J L
Structure of acetylcholinesterase complexed with (-)-galanthamine at 2.3 A resolution.
FEBS letters 1999;463(3):321-6.
1999: Millard C B; Kryger G; Ordentlich A; Greenblatt H M; Harel M; Raves M L; Segall Y; Barak D; Shafferman A; Silman I; Sussman J L
Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level.
Biochemistry 1999;38(22):7032-9.
1999: Morel N; Bon S; Greenblatt H M; Van Belle D; Wodak S J; Sussman J L; Massoulié J; Silman I
Effect of mutations within the peripheral anionic site on the stability of acetylcholinesterase.
Molecular pharmacology 1999;55(6):982-92.
1999: Silman I; Millard C B; Ordentlich A; Greenblatt H M; Harel M; Barak D; Shafferman A; Sussman J L
A preliminary comparison of structural models for catalytic intermediates of acetylcholinesterase.
Chemico-biological interactions 1999;119-120():43-52.
1999: Kryger G; Silman I; Sussman J L
Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs.
Structure (London, England : 1993) 1999;7(3):297-307.
1999: Jiang J; Abola E; Sussman J L
Deposition of structure factors at the Protein Data Bank.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 1):4.
1999: Sussman J L; Abola E E; Lin D; Jiang J; Manning N O; Prilusky J
The protein data bank. Bridging the gap between the sequence and 3D structure world.
Genetica 1999;106(1-2):149-58.
1998: Ravelli R B; Raves M L; Ren Z; Bourgeois D; Roth M; Kroon J; Silman I; Sussman J L
Static Laue diffraction studies on acetylcholinesterase.
Acta crystallographica. Section D, Biological crystallography 1998;54(Pt 6 Pt 2):1359-66.
1998: Sussman J L; Lin D; Jiang J; Manning N O; Prilusky J; Ritter O; Abola E E
Protein Data Bank (PDB): database of three-dimensional structural information of biological macromolecules.
Acta crystallographica. Section D, Biological crystallography 1998;54(Pt 6 Pt 1):1078-84.
1998: Kryger G; Silman I; Sussman J L
Three-dimensional structure of a complex of E2020 with acetylcholinesterase from Torpedo californica.
Journal of physiology, Paris 1998;92(3-4):191-4.
1998: Botti S A; Felder C E; Sussman J L; Silman I
Electrotactins: a class of adhesion proteins with conserved electrostatic and structural motifs.
Protein engineering 1998;11(6):415-20.
1997: Felder C E; Botti S A; Lifson S; Silman I; Sussman J L
External and internal electrostatic potentials of cholinesterase models.
Journal of molecular graphics & modelling 1997;15(5):318-27, 335-7.
1997: Raves M L; Harel M; Pang Y P; Silman I; Kozikowski A P; Sussman J L
Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A.
Nature structural biology 1997;4(1):57-63.
1996: Faerman C; Ripoll D; Bon S; Le Feuvre Y; Morel N; Massoulié J; Sussman J L; Silman I
Site-directed mutants designed to test back-door hypotheses of acetylcholinesterase function.
FEBS letters 1996;386(1):65-71.
1996: Frolow F; Harel M; Sussman J L; Mevarech M; Shoham M
Insights into protein adaptation to a saturated salt environment from the crystal structure of a halophilic 2Fe-2S ferredoxin.
Nature structural biology 1996;3(5):452-8.
1996: Marchot P; Ravelli R B; Raves M L; Bourne Y; Vellom D C; Kanter J; Camp S; Sussman J L; Taylor P
Soluble monomeric acetylcholinesterase from mouse: expression, purification, and crystallization in complex with fasciculin.
Protein science : a publication of the Protein Society 1996;5(4):672-9.
1996: Wlodek S T; Antosiewicz J; McCammon J A; Straatsma T P; Gilson M K; Briggs J M; Humblet C; Sussman J L
Binding of tacrine and 6-chlorotacrine by acetylcholinesterase.
Biopolymers 1996;38(1):109-17.
1995: Harel M; Kleywegt G J; Ravelli R B; Silman I; Sussman J L
Crystal structure of an acetylcholinesterase-fasciculin complex: interaction of a three-fingered toxin from snake venom with its target.
Structure (London, England : 1993) 1995;3(12):1355-66.
1994: Kreimer D I; Dolginova E A; Raves M; Sussman J L; Silman I; Weiner L
A metastable state of Torpedo californica acetylcholinesterase generated by modification with organomercurials.
Biochemistry 1994;33(48):14407-18.
1994: Silman I; Harel M; Axelsen P; Raves M; Sussman J L
Three-dimensional structures of acetylcholinesterase and of its complexes with anticholinesterase agents.
Biochemical Society transactions 1994;22(3):745-9.
1994: Gilson M K; Straatsma T P; McCammon J A; Ripoll D R; Faerman C H; Axelsen P H; Silman I; Sussman J L
Open "back door" in a molecular dynamics simulation of acetylcholinesterase.
Science (New York, N.Y.) 1994;263(5151):1276-8.
1994: Axelsen P H; Harel M; Silman I; Sussman J L
Structure and dynamics of the active site gorge of acetylcholinesterase: synergistic use of molecular dynamics simulation and X-ray crystallography.
Protein science : a publication of the Protein Society 1994;3(2):188-97.
1993: Harel M; Schalk I; Ehret-Sabatier L; Bouet F; Goeldner M; Hirth C; Axelsen P H; Silman I; Sussman J L
Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(19):9031-5.
1993: Livnah O; Bayer E A; Wilchek M; Sussman J L
The structure of the complex between avidin and the dye, 2-(4'-hydroxyazobenzene) benzoic acid (HABA).
FEBS letters 1993;328(1-2):165-8.
1993: Ripoll D R; Faerman C H; Axelsen P H; Silman I; Sussman J L
An electrostatic mechanism for substrate guidance down the aromatic gorge of acetylcholinesterase.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(11):5128-32.
1993: Livnah O; Bayer E A; Wilchek M; Sussman J L
Three-dimensional structures of avidin and the avidin-biotin complex.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(11):5076-80.
1993: Sussman J L; Harel M; Silman I
Three-dimensional structure of acetylcholinesterase and of its complexes with anticholinesterase drugs.
Chemico-biological interactions 1993;87(1-3):187-97.
1993: Wagner U G; Pattridge K A; Ludwig M L; Stallings W C; Werber M M; Oefner C; Frolow F; Sussman J L
Comparison of the crystal structures of genetically engineered human manganese superoxide dismutase and manganese superoxide dismutase from Thermus thermophilus: differences in dimer-dimer interaction.
Protein science : a publication of the Protein Society 1993;2(5):814-25.
1993: Cygler M; Schrag J D; Sussman J L; Harel M; Silman I; Gentry M K; Doctor B P
Relationship between sequence conservation and three-dimensional structure in a large family of esterases, lipases, and related proteins.
Protein science : a publication of the Protein Society 1993;2(3):366-82.
1993: Reich Z; Friedman P; Scolnik Y; Sussman J L; Minsky A
On the metastability of left-handed DNA motifs.
Biochemistry 1993;32(8):2116-9.
1993: Tan R C; Truong T N; McCammon J A; Sussman J L
Acetylcholinesterase: electrostatic steering increases the rate of ligand binding.
Biochemistry 1993;32(2):401-3.
1992: Harel M; Sussman J L; Krejci E; Bon S; Chanal P; Massoulié J; Silman I
Conversion of acetylcholinesterase to butyrylcholinesterase: modeling and mutagenesis.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(22):10827-31.
1992: Berman H M; Sussman J L; Joshua-Tor L; Revich G G; Ripley L S
A structural model for sequence-specific proflavin-DNA interactions during in vitro frameshift mutagenesis.
Journal of biomolecular structure & dynamics 1992;10(2):317-31.
1992: Joshua-Tor L; Frolow F; Appella E; Hope H; Rabinovich D; Sussman J L
Three-dimensional structures of bulge-containing DNA fragments.
Journal of molecular biology 1992;225(2):397-431.
1991: Harel M; Su C T; Frolow F; Ashani Y; Silman I; Sussman J L
Refined crystal structures of "aged" and "non-aged" organophosphoryl conjugates of gamma-chymotrypsin.
Journal of molecular biology 1991;221(3):909-18.
1991: Sussman J L; Harel M; Frolow F; Oefner C; Goldman A; Toker L; Silman I
Atomic structure of acetylcholinesterase from Torpedo californica: a prototypic acetylcholine-binding protein.
Science (New York, N.Y.) 1991;253(5022):872-9.
1991: Harel M; Su C T; Frolow F; Silman I; Sussman J L
Gamma-chymotrypsin is a complex of alpha-chymotrypsin with its own autolysis products.
Biochemistry 1991;30(21):5217-25.
1990: Livnah O; Sussman J L
Crystal forms of avidin.
Methods in enzymology 1990;184():90-3.
1989: Wagner U G; Werber M M; Beck Y; Hartman J R; Frolow F; Sussman J L
Characterization of crystals of genetically engineered human manganese superoxide dismutase.
Journal of molecular biology 1989;206(4):787-8.
1989: Sussman J L; Shoham M; Harel M
Protein adaptation to extreme salinity: the crystal structure of 2Fe-2S ferredoxin from Halobacterium marismortui.
Progress in clinical and biological research 1989;289():171-87.
1988: Sussman J L; Harel M; Frolow F; Varon L; Toker L; Futerman A H; Silman I
Purification and crystallization of a dimeric form of acetylcholinesterase from Torpedo californica subsequent to solubilization with phosphatidylinositol-specific phospholipase C.
Journal of molecular biology 1988;203(3):821-3.
1988: Joshua-Tor L; Rabinovich D; Hope H; Frolow F; Appella E; Sussman J L
The three-dimensional structure of a DNA duplex containing looped-out bases.
Nature 1988;334(6177):82-4.
1988: Harel M; Shoham M; Frolow F; Eisenberg H; Mevarech M; Yonath A; Sussman J L
Crystallization of halophilic malate dehydrogenase from Halobacterium marismortui.
Journal of molecular biology 1988;200(3):609-10.
1988: Hirshberg M; Sharon R; Sussman J L
A kinked model for the solution structure of DNA tridecamers with inserted adenosines: energy minimization and molecular dynamics.
Journal of biomolecular structure & dynamics 1988;5(5):965-79.
1987: Holland D; Zilberstein A; Zamir A; Sussman J L
A quantitative approach to sequence comparisons of nitrogenase MoFe protein alpha- and beta-subunits including the newly sequenced nifK gene from Klebsiella pneumoniae.
The Biochemical journal 1987;247(2):277-85.

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