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Fayyaz Sutterwala

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Lee S Jacobson; Johanna A Joyce; Heriberto Lima; Fayyaz S Sutterwala; Vladislav Tsiperson; Thijn R Brummelkamp; Kartik Chandran; Felipe Diaz-Griffero; Bianca V Gapp; Vasilena Gocheva; Michael F Goldberg; Vincent A Blomen; Jurgen Brojatsch
Cathepsin-mediated necrosis controls the adaptive immune response by Th2 (T helper type 2)-associated adjuvants.
Zhenyu Zhong; Fayyaz S Sutterwala; Yougang Zhai; Renzhi Han; Shuang Liang; Yasuo Mori; Liang Qiao
TRPM2 links oxidative stress to NLRP3 inflammasome activation.
Tyler K Ulland; Blake W Buchan; Suzanne L Cassel; Matthew Faron; Ann M Janowski; Bradley D Jones; Fayyaz S Sutterwala
Francisella tularensis live vaccine strain folate metabolism and pseudouridine synthase gene mutants modulate macrophage caspase-1 activation.

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2013: Lee S Jacobson; Johanna A Joyce; Heriberto Lima; Fayyaz S Sutterwala; Vladislav Tsiperson; Thijn R Brummelkamp; Kartik Chandran; Felipe Diaz-Griffero; Bianca V Gapp; Vasilena Gocheva; Michael F Goldberg; Vincent A Blomen; Jurgen Brojatsch
Cathepsin-mediated necrosis controls the adaptive immune response by Th2 (T helper type 2)-associated adjuvants.
The Journal of biological chemistry 2013;288(11):7481-91.
2013: Zhenyu Zhong; Fayyaz S Sutterwala; Yougang Zhai; Renzhi Han; Shuang Liang; Yasuo Mori; Liang Qiao
TRPM2 links oxidative stress to NLRP3 inflammasome activation.
Nature communications 2013;4():1611.
2013: Tyler K Ulland; Blake W Buchan; Suzanne L Cassel; Matthew Faron; Ann M Janowski; Bradley D Jones; Fayyaz S Sutterwala
Francisella tularensis live vaccine strain folate metabolism and pseudouridine synthase gene mutants modulate macrophage caspase-1 activation.
Infection and immunity 2013;81(1):201-8.
2012: Sophie Joly; Daniel H Kaplan; Alicia K Olivier; Suzanne L Cassel; Stephanie C Eisenbarth; Richard A Flavell; Adam Williams; Fayyaz S Sutterwala
Cutting edge: Nlrp10 is essential for protective antifungal adaptive immunity against Candida albicans.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(10):4713-7.
2012: Ceren Ciraci; John R Janczy; Fayyaz S Sutterwala; Suzanne L Cassel
Control of innate and adaptive immunity by the inflammasome.
Microbes and infection / Institut Pasteur 2012;14(14):1263-70.
2012: Gang Chen; Anthony Choy; Roderick F Felsheim; Michael J Herron; Jennifer L Johns; Michail Kotsyfakis; Jiayu Liao; Ulrike G Munderloh; Olivia S Sakhon; Maiara S Severo; Fayyaz S Sutterwala; Hilda Wiryawan; Joao H F Pedra
Anaplasma phagocytophilum dihydrolipoamide dehydrogenase 1 affects host-derived immunopathology during microbial colonization.
Infection and immunity 2012;80(9):3194-205.
2012: Maria T Kuipers; Jaklien C Leemans; Joris J T H Roelofs; Marcus J Schultz; Fayyaz S Sutterwala; Tom van der Poll; Koenraad F van der Sluijs; Alexander P J Vlaar; Hamid Aslami; Paul Bresser; Goda Choi; Richard A Flavell; John R Janczy; Esther K Wolthuis; Catharina W Wieland
Ventilator-induced lung injury is mediated by the NLRP3 inflammasome.
Anesthesiology 2012;116(5):1104-15.
2012: Stephanie C Eisenbarth; Eran Elinav; Oscar R Colegio; David G Gonzalez; Ann M Haberman; Jorge Henao-Mejia; Sophie Joly; Steven H Kleinstein; Hailong Meng; Anthony Rongvaux; Till Strowig; Fayyaz S Sutterwala; Christoph A Thaiss; Adam Williams; Lan Xu; Lauren A Zenewicz; Richard A Flavell
NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells.
Nature 2012;484(7395):510-3.
2012: Ceren Ciraci; Fayyaz S Sutterwala
Inhibitors of apoptosis proteins and IL-1β: a tangled relationship.
Immunity 2012;36(2):155-7.
2012: Hana Abdalla; Katrin D Mayer-Barber; Swati Shah; Alan Sher; Lalitha Srinivasan; Fayyaz S Sutterwala; Volker Briken
Mycobacterium tuberculosis infection of dendritic cells leads to partially caspase-1/11-independent IL-1β and IL-18 secretion but not to pyroptosis.
PloS one 2012;7(7):e40722.
2012: Brian Scharf; Fayyaz S Sutterwala; Xiao-Xuan Wu; Diego Zanolini; Cristina Clement; Neil Cobelli; Antonia Follenzi; Katherine A Hajjar; JN Larocca; kalle levon; Kateryna Morozova; Ed Purdue; Jacob H Rand; Laura Santambrogio
Annexin A2 binds to endosomes following organelle destabilization by particulate wear debris.
Nature communications 2012;3():755.
2011: Jaklien C Leemans; Suzanne L Cassel; Fayyaz S Sutterwala
Sensing damage by the NLRP3 inflammasome.
Immunological reviews 2011;243(1):152-62.
2010: Janelle C Arthur; John D Lich; Zhengmao Ye; Irving C Allen; Denis Gris; Justin E Wilson; Monika Schneider; Kelly E Roney; Brian P O'Connor; Chris B Moore; Amy Morrison; Fayyaz S Sutterwala; John Bertin; Beverly H Koller; Zhi Liu; Jenny P-Y Ting
Cutting edge: NLRP12 controls dendritic and myeloid cell migration to affect contact hypersensitivity.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(8):4515-9.
2010: Tyler K Ulland; Blake W Buchan; Margaret R Ketterer; Teresa Fernandes-Alnemri; David K Meyerholz; Michael A Apicella; Emad S Alnemri; Bradley D Jones; William M Nauseef; Fayyaz S Sutterwala
Cutting edge: mutation of Francisella tularensis mviN leads to increased macrophage absent in melanoma 2 inflammasome activation and a loss of virulence.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(5):2670-4.
2010: Igor E Brodsky; Noah W Palm; Saheli Sadanand; Michelle B Ryndak; Fayyaz S Sutterwala; Richard A Flavell; James B Bliska; Ruslan Medzhitov
A Yersinia effector protein promotes virulence by preventing inflammasome recognition of the type III secretion system.
Cell host & microbe 2010;7(5):376-87.
2010: Katrin D Mayer-Barber; Daniel L Barber; Kevin Shenderov; Sandra D White; Mark S Wilson; Allen Cheever; David Kugler; Sara Hieny; Patricia Caspar; Gabriel Núñez; Dirk Schlueter; Richard A Flavell; Fayyaz S Sutterwala; Alan Sher
Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(7):3326-30.
2010: Suzanne L Cassel; Fayyaz S Sutterwala
Sterile inflammatory responses mediated by the NLRP3 inflammasome.
European journal of immunology 2010;40(3):607-11.
2009: Shankar S Iyer; Wilco P Pulskens; Jeffrey J Sadler; Loes M Butter; Gwendoline J Teske; Tyler K Ulland; Stephanie C Eisenbarth; Sandrine Florquin; Richard A Flavell; Jaklien C Leemans; Fayyaz S Sutterwala
Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(48):20388-93.
2009: Sophie Joly; Ning Ma; Jeffrey J Sadler; David R Soll; Suzanne L Cassel; Fayyaz S Sutterwala
Cutting edge: Candida albicans hyphae formation triggers activation of the Nlrp3 inflammasome.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(6):3578-81.
2009: Marina Tiemi Shio; Marina Tiemi Shio; Stephanie C Eisenbarth; Myriam Savaria; Adrien Vinet; Marie-Josée Bellemare; Kenneth W Harder; Fayyaz S Sutterwala; D Scott Bohle; Albert Descoteaux; Richard A Flavell; Martin Olivier
Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases.
PLoS pathogens 2009;5(8):e1000559.
2009: Suzanne L Cassel; Sophie Joly; Fayyaz S Sutterwala
The NLRP3 inflammasome: a sensor of immune danger signals.
Seminars in immunology 2009;21(4):194-8.
2009: Joao H F Pedra; Suzanne L Cassel; Fayyaz S Sutterwala
Sensing pathogens and danger signals by the inflammasome.
Current opinion in immunology 2009;21(1):10-6.
2009: Avlin B Imaeda; Azuma Watanabe; Muhammad A Sohail; Shamail Mahmood; Mehdi Mohamadnejad; Fayyaz S Sutterwala; Richard A Flavell; Wajahat Z Mehal
Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome.
The Journal of clinical investigation 2009;119(2):305-14.
2008: Suzanne L Cassel; Stephanie C Eisenbarth; Shankar S Iyer; Jeffrey J Sadler; Oscar R Colegio; Linda Tephly; A Brent Carter; Paul B Rothman; Richard A Flavell; Fayyaz S Sutterwala
The Nalp3 inflammasome is essential for the development of silicosis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(26):9035-40.
2008: Stephanie C Eisenbarth; Oscar R Colegio; William O'Connor; Fayyaz S Sutterwala; Richard A Flavell
Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants.
Nature 2008;453(7198):1122-6.
2008: Suzanne L Cassel; Fayyaz S Sutterwala; Richard A Flavell
The tiny conductor: immune regulation via commensal organisms.
Cell host & microbe 2008;3(6):340-1.
2008: Núria Reig; Aimin Jiang; Rachael Couture; Fayyaz S Sutterwala; Yasunori Ogura; Richard A Flavell; Ira Mellman; F Gisou van der Goot
Maturation modulates caspase-1-independent responses of dendritic cells to Anthrax lethal toxin.
Cellular microbiology 2008;10(5):1190-207.
2008: Fayyaz S Sutterwala; Richard A Flavell
Immunology: cascade into clarity.
Nature 2008;451(7176):254-5.
2007: Fayyaz S Sutterwala; Lilia Mijares; Li Li; Yasunori Ogura; Barbara I Kazmierczak; Richard A Flavell
Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome.
The Journal of experimental medicine 2007;204(13):3235-45.
2007: Joao H F Pedra; Fayyaz S Sutterwala; Bindu Sukumaran; Yasunori Ogura; Qian Feng; Ruth R Montgomery; Richard A Flavell; Erol Fikrig
ASC/PYCARD and caspase-1 regulate the IL-18/IFN-gamma axis during Anaplasma phagocytophilum infection.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(7):4783-91.
2007: Joao H F Pedra; Jian Tao; Fayyaz S Sutterwala; Bindu Sukumaran; Nancy Berliner; Linda K Bockenstedt; Richard A Flavell; Zhinan Yin; Erol Fikrig
IL-12/23p40-dependent clearance of Anaplasma phagocytophilum in the murine model of human anaplasmosis.
FEMS immunology and medical microbiology 2007;50(3):401-10.
2007: Fayyaz S Sutterwala; Yasunori Ogura; Richard A Flavell
The inflammasome in pathogen recognition and inflammation.
Journal of leukocyte biology 2007;82(2):259-64.
2007: Qilin Pan; John C Mathison; Colleen Fearns; Vladimir V Kravchenko; Jean da Silva Correia; Hal M Hoffman; Koichi Kobayashi; John Bertin; Ethan P Grant; Anthony J Coyle; Fayyaz S Sutterwala; Yasunori Ogura; Richard A Flavell; Richard J Ulevitch
MDP-induced interleukin-1beta processing requires Nod2 and CIAS1/NALP3.
Journal of leukocyte biology 2007;82(1):177-83.
2006: Masahito Kamanaka; Sean T Kim; Yisong Y Wan; Fayyaz S Sutterwala; María Lara-Tejero; Jorge E Galán; Edward W Harhaj; Richard A Flavell
Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse.
Immunity 2006;25(6):941-52.
2006: Yasunori Ogura; Fayyaz S Sutterwala; Richard A Flavell
The inflammasome: first line of the immune response to cell stress.
Cell 2006;126(4):659-62.
2006: María Lara-Tejero; Fayyaz S Sutterwala; Yasunori Ogura; Ethan P Grant; John Bertin; Anthony J Coyle; Richard A Flavell; Jorge E Galán
Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis.
The Journal of experimental medicine 2006;203(6):1407-12.
2006: Fayyaz S Sutterwala; Yasunori Ogura; Marian Szczepanik; María Lara-Tejero; G Scott Lichtenberger; Ethan P Grant; John Bertin; Anthony J Coyle; Jorge E Galán; Philip W Askenase; Richard A Flavell
Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1.
Immunity 2006;24(3):317-27.
2006: Fayyaz S Sutterwala; Yasunori Ogura; Dario S Zamboni; Craig R Roy; Richard A Flavell
NALP3: a key player in caspase-1 activation.
Journal of endotoxin research 2006;12(4):251-6.
2005: Felix Yarovinsky; Dekai Zhang; John F Andersen; Gerard Bannenberg; Charles N Serhan; Matthew Hayden; Sara Hieny; Fayyaz S Sutterwala; Richard A Flavell; Sankar Ghosh; Alan Sher
TLR11 activation of dendritic cells by a protozoan profilin-like protein.
Science (New York, N.Y.) 2005;308(5728):1626-9.
2005: Yasmina Laouar; Fayyaz S Sutterwala; Leonid Gorelik; Richard A Flavell
Transforming growth factor-beta controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma.
Nature immunology 2005;6(6):600-7.