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PD Suzdak

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TOP 3
KE Andersen; J Lau; BF Lundt; H Petersen; PO Huusfeldt; PD Suzdak; MD Swedberg
Synthesis of novel GABA uptake inhibitors. Part 6: preparation and evaluation of N-Omega asymmetrically substituted nipecotic acid derivatives.
KE Andersen; J L Sørensen; J Lau; BF Lundt; H Petersen; PO Huusfeldt; PD Suzdak; MD Swedberg
Synthesis of novel gamma-aminobutyric acid (GABA) uptake inhibitors. 5.(1) Preparation and structure-activity studies of tricyclic analogues of known GABA uptake inhibitors.
KE Andersen; J L Sørensen; PO Huusfeldt; Lars Knutsen; J Lau; BF Lundt; H Petersen; PD Suzdak; MD Swedberg
Synthesis of novel GABA uptake inhibitors. 4. Bioisosteric transformation and successive optimization of known GABA uptake inhibitors leading to a series of potent anticonvulsant drug candidates.

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All Publications

2001: KE Andersen; J Lau; BF Lundt; H Petersen; PO Huusfeldt; PD Suzdak; MD Swedberg
Synthesis of novel GABA uptake inhibitors. Part 6: preparation and evaluation of N-Omega asymmetrically substituted nipecotic acid derivatives.
Bioorganic & medicinal chemistry 2001;9(11):2773-85.
2001: KE Andersen; J L Sørensen; J Lau; BF Lundt; H Petersen; PO Huusfeldt; PD Suzdak; MD Swedberg
Synthesis of novel gamma-aminobutyric acid (GABA) uptake inhibitors. 5.(1) Preparation and structure-activity studies of tricyclic analogues of known GABA uptake inhibitors.
Journal of medicinal chemistry 2001;44(13):2152-63.
1999: KE Andersen; J L Sørensen; PO Huusfeldt; Lars Knutsen; J Lau; BF Lundt; H Petersen; PD Suzdak; MD Swedberg
Synthesis of novel GABA uptake inhibitors. 4. Bioisosteric transformation and successive optimization of known GABA uptake inhibitors leading to a series of potent anticonvulsant drug candidates.
Journal of medicinal chemistry 1999;42(21):4281-91.
1999: Lars Knutsen; KE Andersen; J Lau; BF Lundt; R F Henry; H E Morton; L Naerum; H Petersen; H Stephensen; PD Suzdak; MD Swedberg; C Thomsen; P O Sørensen
Synthesis of novel GABA uptake inhibitors. 3. Diaryloxime and diarylvinyl ether derivatives of nipecotic acid and guvacine as anticonvulsant agents.
Journal of medicinal chemistry 1999;42(18):3447-62.
1997: Harlan E Shannon; MJ Sheardown; Frank P Bymaster; David O Calligaro; Neil DeLapp; J Gidda; Charles H Mitch; BD Sawyer; Peter stengel; JS Ward; David T Wong; Preben Olesen; PD Suzdak; Per Sauerberg; MD Swedberg
Pharmacology of butylthio[2.2.2] (LY297802/NNC11-1053): a novel analgesic with mixed muscarinic receptor agonist and antagonist activity.
The Journal of pharmacology and experimental therapeutics 1997;281(2):884-94.
1997: MD Swedberg; MJ Sheardown; Per Sauerberg; Preben Olesen; PD Suzdak; Kristian Tage Hansen; Frank P Bymaster; JS Ward; Charles H Mitch; David O Calligaro; Neil DeLapp; Harlan E Shannon
Butylthio[2.2.2] (NNC 11-1053/LY297802): an orally active muscarinic agonist analgesic.
The Journal of pharmacology and experimental therapeutics 1997;281(2):876-83.
1997: MJ Sheardown; Harlan E Shannon; MD Swedberg; PD Suzdak; Frank P Bymaster; Preben Olesen; Charles H Mitch; JS Ward; Per Sauerberg
M1 receptor agonist activity is not a requirement for muscarinic antinociception.
The Journal of pharmacology and experimental therapeutics 1997;281(2):868-75.
1997: Charles H Mitch; T J Brown; Frank P Bymaster; David O Calligaro; Donna K Dieckman; L Merrit; Steven C Peters; Steven J Quimby; Harlan E Shannon; L A Shipley; JS Ward; K Hansen; Preben Olesen; Per Sauerberg; MJ Sheardown; MD Swedberg; PD Suzdak; B Greenwood
Muscarinic analgesics with potent and selective effects on the gastrointestinal tract: potential application for the treatment of irritable bowel syndrome.
Journal of medicinal chemistry 1997;40(4):538-46.
1996: H C Jackson; H C Hansen; M Kristiansen; PD Suzdak; H Klitgaard; Martin Judge; MD Swedberg
Anticonvulsant profile of the imidazoquinazolines NNC 14-0185 and NNC 14-0189 in rats and mice.
European journal of pharmacology 1996;308(1):21-30.
1996: Lars Farde; T Suhara; Christer Halldin; H Nybäck; Y Nakashima; Carl-Gunnar Swahn; Per Karlsson; N Ginovart; Frank P Bymaster; Harlan E Shannon; C Foged; PD Suzdak; Per Sauerberg
PET study of the M1-agonists [11C]xanomeline and [11C]butylthio-TZTP in monkey and man.
Dementia (Basel, Switzerland) 1996;7(4):187-95.
1995: M Mortensen; PD Suzdak; C Thomsen
The effect of lorazepam tolerance and withdrawal on metabotropic glutamate receptor function.
The Journal of pharmacology and experimental therapeutics 1995;274(1):155-63.
1995: G Wong; Mikko Uusi-Oukari; H C Hansen; PD Suzdak; Esa R Korpi
Characterization of novel ligands for wild-type and natural mutant diazepam-insensitive benzodiazepine receptors.
European journal of pharmacology 1995;289(2):335-42.
1995: Per Sauerberg; Preben Olesen; MJ Sheardown; PD Suzdak; Harlan E Shannon; Frank P Bymaster; David O Calligaro; Charles H Mitch; JS Ward; MD Swedberg
Muscarinic agonists as analgesics. Antinociceptive activity versus M1 activity: SAR of alkylthio-TZTP's and related 1,2,5-thiadiazole analogs.
Life sciences 1995;56(11-12):807-14.
1994: C Thomsen; A Bau; P Faarup; C Foged; A Kanstrup; PD Suzdak
Effects of bromohomoibotenate on metabotropic glutamate receptors.
Neuroreport 1994;5(18):2417-20.
1994: C Thomsen; L Hansen; PD Suzdak
L-glutamate uptake inhibitors may stimulate phosphoinositide hydrolysis in baby hamster kidney cells expressing mGluR1a via heteroexchange with L-glutamate without direct activation of mGluR1a.
Journal of neurochemistry 1994;63(6):2038-47.
1994: PD Suzdak
Lack of tolerance to the anticonvulsant effects of tiagabine following chronic (21 day) treatment.
Epilepsy research 1994;19(3):205-13.
1994: PD Suzdak; C Foged; KE Andersen
Quantitative autoradiographic characterization of the binding of [3H]tiagabine (NNC 05-328) to the GABA uptake carrier.
Brain research 1994;647(2):231-41.
1994: C Thomsen; H Klitgaard; MJ Sheardown; H C Jackson; K Eskesen; P Jacobsen; S Treppendahl; PD Suzdak
(S)-4-carboxy-3-hydroxyphenylglycine, an antagonist of metabotropic glutamate receptor (mGluR) 1a and an agonist of mGluR2, protects against audiogenic seizures in DBA/2 mice.
Journal of neurochemistry 1994;62(6):2492-5.
1994: Frank P Bymaster; David T Wong; Charles H Mitch; JS Ward; David O Calligaro; Darryle D Schoepp; Harlan E Shannon; MJ Sheardown; Preben Olesen; PD Suzdak
Neurochemical effects of the M1 muscarinic agonist xanomeline (LY246708/NNC11-0232).
The Journal of pharmacology and experimental therapeutics 1994;269(1):282-9.
1994: C Thomsen; E Boel; PD Suzdak
Actions of phenylglycine analogs at subtypes of the metabotropic glutamate receptor family.
European journal of pharmacology 1994;267(1):77-84.
1993: PD Suzdak; MJ Sheardown
Effect of the non-NMDA receptor antagonist, 2,3-dihydro-6-nitro-7-sulfamoylbenzo(f)quinoxaline, on local cerebral glucose uptake in the limbic forebrain.
Journal of neurochemistry 1993;61(4):1577-80.
1993: C Thomsen; PD Suzdak
Serine-O-phosphate has affinity for type IV, but not type I, metabotropic glutamate receptor.
Neuroreport 1993;4(9):1099-101.
1993: KE Andersen; C Braestrup; F C Grønwald; A S Jørgensen; E B Nielsen; U Sonnewald; P O Sørensen; PD Suzdak; Lars Knutsen
The synthesis of novel GABA uptake inhibitors. 1. Elucidation of the structure-activity studies leading to the choice of (R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic acid (tiagabine) as an anticonvulsant drug candidate.
Journal of medicinal chemistry 1993;36(12):1716-25.
1993: MJ Sheardown; PD Suzdak; L Nordholm
AMPA, but not NMDA, receptor antagonism is neuroprotective in gerbil global ischaemia, even when delayed 24 h.
European journal of pharmacology 1993;236(3):347-53.
1993: C Thomsen; PD Suzdak
4-Carboxy-3-hydroxyphenylglycine, an antagonist at type I metabotropic glutamate receptors.
European journal of pharmacology 1993;245(3):299-301.
1993: PD Suzdak; MJ Sheardown; T Honoré
Characterization of the metabotropic glutamate receptor in mouse cerebellar granule cells: lack of effect of 2,3-dihydroxy-6-nitro-7-sulphamoylbenzo(F)-quinoxaline (NBQX).
European journal of pharmacology 1993;245(3):215-20.
1992: PD Suzdak; K Frederiksen; KE Andersen; P O Sørensen; Lars Knutsen; E B Nielsen
NNC-711, a novel potent and selective gamma-aminobutyric acid uptake inhibitor: pharmacological characterization.
European journal of pharmacology 1992;224(2-3):189-98.
1992: Anders Fink-Jensen; PD Suzdak; MD Swedberg; Martin Judge; L Hansen; P G Nielsen
The gamma-aminobutyric acid (GABA) uptake inhibitor, tiagabine, increases extracellular brain levels of GABA in awake rats.
European journal of pharmacology 1992;220(2-3):197-201.
1992: Esa R Korpi; Mikko Uusi-Oukari; E Castren; PD Suzdak; T Seppälä; Maija Sarviharju; K Tuominen
Cerebellar GABAA receptors in two rat lines selected for high and low sensitivity to moderate alcohol doses: pharmacological and genetic studies.
Alcohol (Fayetteville, N.Y.) 1992;9(3):225-31.
1992: PD Suzdak; MD Swedberg; KE Andersen; Lars Knutsen; C Braestrup
In vivo labeling of the central GABA uptake carrier with 3H-Tiagabine.
Life sciences 1992;51(24):1857-68.
1991: E B Nielsen; PD Suzdak; KE Andersen; Lars Knutsen; U Sonnewald; C Braestrup
Characterization of tiagabine (NO-328), a new potent and selective GABA uptake inhibitor.
European journal of pharmacology 1991;196(3):257-66.
1990: C Braestrup; E B Nielsen; U Sonnewald; Lars Knutsen; KE Andersen; J A Jansen; K Frederiksen; P H Andersen; A Mortensen; PD Suzdak
(R)-N-[4,4-bis(3-methyl-2-thienyl)but-3-en-1-yl]nipecotic acid binds with high affinity to the brain gamma-aminobutyric acid uptake carrier.
Journal of neurochemistry 1990;54(2):639-47.
1990: Esa R Korpi; K Tuominen; Mikko Uusi-Oukari; P Saransaari; S S Oja; PD Suzdak
Mechanisms of alcohol intoxication in a rodent model: blunted alcohol-opposing reaction in "alcohol-sensitive" rats.
Annals of medicine 1990;22(4):253-8.